FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4325, 436 aa 1>>>pF1KB4325 436 - 436 aa - 436 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8716+/-0.000346; mu= 16.3563+/- 0.022 mean_var=102.0222+/-20.689, 0's: 0 Z-trim(117.9): 131 B-trim: 752 in 1/51 Lambda= 0.126978 statistics sampled from 30236 (30371) to 30236 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.719), E-opt: 0.2 (0.356), width: 16 Scan time: 9.990 The best scores are: opt bits E(85289) NP_004562 (OMIM: 602100) homeobox protein PKNOX1 i ( 436) 2855 533.3 4.6e-151 NP_001307623 (OMIM: 602100) homeobox protein PKNOX ( 435) 2836 529.9 5.1e-150 NP_001273187 (OMIM: 602100) homeobox protein PKNOX ( 319) 2063 388.1 1.7e-107 XP_011541249 (OMIM: 613066) PREDICTED: homeobox pr ( 339) 951 184.4 3.8e-46 XP_006718957 (OMIM: 613066) PREDICTED: homeobox pr ( 339) 951 184.4 3.8e-46 XP_016873600 (OMIM: 613066) PREDICTED: homeobox pr ( 339) 951 184.4 3.8e-46 XP_016873599 (OMIM: 613066) PREDICTED: homeobox pr ( 472) 794 155.8 2.2e-37 XP_011541247 (OMIM: 613066) PREDICTED: homeobox pr ( 472) 794 155.8 2.2e-37 NP_071345 (OMIM: 613066) homeobox protein PKNOX2 [ ( 472) 794 155.8 2.2e-37 XP_011541246 (OMIM: 613066) PREDICTED: homeobox pr ( 472) 794 155.8 2.2e-37 XP_005271699 (OMIM: 613066) PREDICTED: homeobox pr ( 472) 794 155.8 2.2e-37 XP_005271700 (OMIM: 613066) PREDICTED: homeobox pr ( 443) 745 146.8 1.1e-34 XP_011541248 (OMIM: 613066) PREDICTED: homeobox pr ( 356) 735 144.9 3.2e-34 XP_016873601 (OMIM: 613066) PREDICTED: homeobox pr ( 327) 686 135.9 1.5e-31 NP_002390 (OMIM: 601740) homeobox protein Meis2 is ( 381) 456 93.8 8.2e-19 XP_006720588 (OMIM: 601740) PREDICTED: homeobox pr ( 393) 456 93.8 8.3e-19 NP_733774 (OMIM: 601740) homeobox protein Meis2 is ( 394) 456 93.8 8.4e-19 NP_001207411 (OMIM: 601740) homeobox protein Meis2 ( 470) 457 94.1 8.4e-19 NP_733776 (OMIM: 601740) homeobox protein Meis2 is ( 470) 457 94.1 8.4e-19 NP_002389 (OMIM: 601739) homeobox protein Meis1 [H ( 390) 443 91.4 4.3e-18 XP_005264380 (OMIM: 601739) PREDICTED: homeobox pr ( 406) 443 91.5 4.5e-18 XP_006720586 (OMIM: 601740) PREDICTED: homeobox pr ( 476) 441 91.1 6.5e-18 NP_733775 (OMIM: 601740) homeobox protein Meis2 is ( 477) 441 91.1 6.5e-18 NP_758526 (OMIM: 601740) homeobox protein Meis2 is ( 388) 436 90.2 1e-17 XP_006720587 (OMIM: 601740) PREDICTED: homeobox pr ( 400) 436 90.2 1.1e-17 NP_733777 (OMIM: 601740) homeobox protein Meis2 is ( 401) 436 90.2 1.1e-17 XP_005264379 (OMIM: 601739) PREDICTED: homeobox pr ( 465) 432 89.5 2e-17 XP_005264378 (OMIM: 601739) PREDICTED: homeobox pr ( 481) 432 89.5 2e-17 XP_016859631 (OMIM: 601739) PREDICTED: homeobox pr ( 417) 427 88.5 3.5e-17 XP_016859630 (OMIM: 601739) PREDICTED: homeobox pr ( 433) 427 88.5 3.6e-17 XP_005264382 (OMIM: 601739) PREDICTED: homeobox pr ( 325) 412 85.7 1.9e-16 XP_005264381 (OMIM: 601739) PREDICTED: homeobox pr ( 400) 401 83.8 9.1e-16 XP_016859632 (OMIM: 601739) PREDICTED: homeobox pr ( 352) 396 82.8 1.6e-15 NP_758527 (OMIM: 601740) homeobox protein Meis2 is ( 306) 377 79.3 1.6e-14 XP_016877694 (OMIM: 601740) PREDICTED: homeobox pr ( 306) 377 79.3 1.6e-14 XP_016859635 (OMIM: 601739) PREDICTED: homeobox pr ( 246) 375 78.8 1.7e-14 XP_016859634 (OMIM: 601739) PREDICTED: homeobox pr ( 321) 364 76.9 8.5e-14 XP_016859633 (OMIM: 601739) PREDICTED: homeobox pr ( 321) 364 76.9 8.5e-14 XP_006720589 (OMIM: 601740) PREDICTED: homeobox pr ( 389) 362 76.6 1.3e-13 XP_011519893 (OMIM: 601740) PREDICTED: homeobox pr ( 331) 360 76.2 1.4e-13 XP_006720590 (OMIM: 601740) PREDICTED: homeobox pr ( 331) 360 76.2 1.4e-13 XP_006720592 (OMIM: 601740) PREDICTED: homeobox pr ( 255) 355 75.2 2.2e-13 NP_620410 (OMIM: 300411) homeobox protein TGIF2LX ( 241) 261 57.9 3.3e-08 NP_775299 (OMIM: 142946,602630) homeobox protein T ( 286) 260 57.8 4.2e-08 NP_631960 (OMIM: 400025) homeobox protein TGIF2LY ( 185) 255 56.7 5.8e-08 NP_003235 (OMIM: 142946,602630) homeobox protein T ( 272) 254 56.7 8.7e-08 NP_001265613 (OMIM: 142946,602630) homeobox protei ( 272) 254 56.7 8.7e-08 NP_775300 (OMIM: 142946,602630) homeobox protein T ( 272) 254 56.7 8.7e-08 XP_016881447 (OMIM: 142946,602630) PREDICTED: home ( 272) 254 56.7 8.7e-08 NP_733796 (OMIM: 142946,602630) homeobox protein T ( 401) 254 56.8 1.2e-07 >>NP_004562 (OMIM: 602100) homeobox protein PKNOX1 isofo (436 aa) initn: 2855 init1: 2855 opt: 2855 Z-score: 2833.1 bits: 533.3 E(85289): 4.6e-151 Smith-Waterman score: 2855; 100.0% identity (100.0% similar) in 436 aa overlap (1-436:1-436) 10 20 30 40 50 60 pF1KB4 MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSEPDAEGVSPPPVESQTPMDVDKQAIYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSEPDAEGVSPPPVESQTPMDVDKQAIYR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 HPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 AIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 TGTISPQGIVVPASALQQGNVAMATVAGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TGTISPQGIVVPASALQQGNVAMATVAGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 LQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 LTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGVAQPPPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGVAQPPPS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 ELTMSEGAVVTITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEEDAGALA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ELTMSEGAVVTITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEEDAGALA 370 380 390 400 410 420 430 pF1KB4 PAHISGLVLENSDSLQ :::::::::::::::: NP_004 PAHISGLVLENSDSLQ 430 >>NP_001307623 (OMIM: 602100) homeobox protein PKNOX1 is (435 aa) initn: 1688 init1: 1688 opt: 2836 Z-score: 2814.3 bits: 529.9 E(85289): 5.1e-150 Smith-Waterman score: 2836; 99.8% identity (99.8% similar) in 436 aa overlap (1-436:1-435) 10 20 30 40 50 60 pF1KB4 MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSEPDAEGVSPPPVESQTPMDVDKQAIYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSEPDAEGVSPPPVESQTPMDVDKQAIYR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 HPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 AIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAI :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: NP_001 AIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQ-IQSAI 130 140 150 160 170 190 200 210 220 230 240 pF1KB4 TGTISPQGIVVPASALQQGNVAMATVAGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGTISPQGIVVPASALQQGNVAMATVAGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQ 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB4 LQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTN 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB4 LTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGVAQPPPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGVAQPPPS 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB4 ELTMSEGAVVTITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEEDAGALA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELTMSEGAVVTITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEEDAGALA 360 370 380 390 400 410 430 pF1KB4 PAHISGLVLENSDSLQ :::::::::::::::: NP_001 PAHISGLVLENSDSLQ 420 430 >>NP_001273187 (OMIM: 602100) homeobox protein PKNOX1 is (319 aa) initn: 2063 init1: 2063 opt: 2063 Z-score: 2050.8 bits: 388.1 E(85289): 1.7e-107 Smith-Waterman score: 2063; 100.0% identity (100.0% similar) in 319 aa overlap (118-436:1-319) 90 100 110 120 130 140 pF1KB4 SFDVDIENFVRKQEKEGKPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYI :::::::::::::::::::::::::::::: NP_001 MVKAIQVLRIHLLELEKVNELCKDFCSRYI 10 20 30 150 160 170 180 190 200 pF1KB4 ACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAITGTISPQGIVVPASALQQGNVAMATVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAITGTISPQGIVVPASALQQGNVAMATVA 40 50 60 70 80 90 210 220 230 240 250 260 pF1KB4 GGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQLQLQLNQDLSILHQDDGSSKNKRGVLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQLQLQLNQDLSILHQDDGSSKNKRGVLP 100 110 120 130 140 150 270 280 290 300 310 320 pF1KB4 KHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCS 160 170 180 190 200 210 330 340 350 360 370 380 pF1KB4 ETPKTKKKTAQNRPVQRFWPDSIASGVAQPPPSELTMSEGAVVTITTPVNMNVDSLQSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETPKTKKKTAQNRPVQRFWPDSIASGVAQPPPSELTMSEGAVVTITTPVNMNVDSLQSLS 220 230 240 250 260 270 390 400 410 420 430 pF1KB4 SDGATLAVQQVMMAGQSEDESVDSTEEDAGALAPAHISGLVLENSDSLQ ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDGATLAVQQVMMAGQSEDESVDSTEEDAGALAPAHISGLVLENSDSLQ 280 290 300 310 >>XP_011541249 (OMIM: 613066) PREDICTED: homeobox protei (339 aa) initn: 1133 init1: 457 opt: 951 Z-score: 949.5 bits: 184.4 E(85289): 3.8e-46 Smith-Waterman score: 1209; 58.5% identity (79.0% similar) in 352 aa overlap (118-436:1-339) 90 100 110 120 130 140 pF1KB4 SFDVDIENFVRKQEKEGKPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYI ::::::::::::::::::::::::::.::: XP_011 MVKAIQVLRIHLLELEKVNELCKDFCNRYI 10 20 30 150 160 170 180 190 pF1KB4 ACLKTKMNSETLLSGEPGSPYSPVQ------SQQI----QSAITG-TISPQGIVVPASAL .::::::.:..:: .. :.:::: : ::.. ....: . .::::::::::: XP_011 TCLKTKMHSDNLLRNDLGGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASAL 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB4 QQGNVAMATV-----AGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQLQLQLNQDLSI ::::.::.:: .::..:::::.:: :::::::.. :.:.:::.:..:.:. :. XP_011 QQGNIAMTTVNSQVVSGGALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLT---SL 100 110 120 130 140 260 270 280 290 300 310 pF1KB4 LHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFI : ..: .::::::::::::::.::::::::. :::::::::.:::::::::::::::::: XP_011 LDNEDKKSKNKRGVLPKHATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFI 150 160 170 180 190 200 320 330 340 350 360 370 pF1KB4 NARRRILQPMLDSSCSE-TPKTKKKTAQNRPVQRFWPDSIASGVAQPPPSELTMSEGAVV ::::::::::::.: . .::.:: .:.::.:::::.:::.:: : ..:.. XP_011 NARRRILQPMLDASNPDPAPKAKKIKSQHRPTQRFWPNSIAAGVLQ--------QQGGAP 210 220 230 240 250 380 390 400 410 pF1KB4 TITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEED--------------- . ..:.:.:::::::.::.:.::.:::.. :.:.:.:::. XP_011 GTNPDGSINLDNLQSLSSDSATMAMQQAMMAAH--DDSLDGTEEEDEDEMEEEEEEELEE 260 270 280 290 300 310 420 430 pF1KB4 -AGALAPAHISGLVLENSDSLQ . : ...: : ::.::::. XP_011 EVDELQTTNVSDLGLEHSDSLE 320 330 >>XP_006718957 (OMIM: 613066) PREDICTED: homeobox protei (339 aa) initn: 1133 init1: 457 opt: 951 Z-score: 949.5 bits: 184.4 E(85289): 3.8e-46 Smith-Waterman score: 1209; 58.5% identity (79.0% similar) in 352 aa overlap (118-436:1-339) 90 100 110 120 130 140 pF1KB4 SFDVDIENFVRKQEKEGKPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYI ::::::::::::::::::::::::::.::: XP_006 MVKAIQVLRIHLLELEKVNELCKDFCNRYI 10 20 30 150 160 170 180 190 pF1KB4 ACLKTKMNSETLLSGEPGSPYSPVQ------SQQI----QSAITG-TISPQGIVVPASAL .::::::.:..:: .. :.:::: : ::.. ....: . .::::::::::: XP_006 TCLKTKMHSDNLLRNDLGGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASAL 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB4 QQGNVAMATV-----AGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQLQLQLNQDLSI ::::.::.:: .::..:::::.:: :::::::.. :.:.:::.:..:.:. :. XP_006 QQGNIAMTTVNSQVVSGGALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLT---SL 100 110 120 130 140 260 270 280 290 300 310 pF1KB4 LHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFI : ..: .::::::::::::::.::::::::. :::::::::.:::::::::::::::::: XP_006 LDNEDKKSKNKRGVLPKHATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFI 150 160 170 180 190 200 320 330 340 350 360 370 pF1KB4 NARRRILQPMLDSSCSE-TPKTKKKTAQNRPVQRFWPDSIASGVAQPPPSELTMSEGAVV ::::::::::::.: . .::.:: .:.::.:::::.:::.:: : ..:.. XP_006 NARRRILQPMLDASNPDPAPKAKKIKSQHRPTQRFWPNSIAAGVLQ--------QQGGAP 210 220 230 240 250 380 390 400 410 pF1KB4 TITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEED--------------- . ..:.:.:::::::.::.:.::.:::.. :.:.:.:::. XP_006 GTNPDGSINLDNLQSLSSDSATMAMQQAMMAAH--DDSLDGTEEEDEDEMEEEEEEELEE 260 270 280 290 300 310 420 430 pF1KB4 -AGALAPAHISGLVLENSDSLQ . : ...: : ::.::::. XP_006 EVDELQTTNVSDLGLEHSDSLE 320 330 >>XP_016873600 (OMIM: 613066) PREDICTED: homeobox protei (339 aa) initn: 1133 init1: 457 opt: 951 Z-score: 949.5 bits: 184.4 E(85289): 3.8e-46 Smith-Waterman score: 1209; 58.5% identity (79.0% similar) in 352 aa overlap (118-436:1-339) 90 100 110 120 130 140 pF1KB4 SFDVDIENFVRKQEKEGKPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYI ::::::::::::::::::::::::::.::: XP_016 MVKAIQVLRIHLLELEKVNELCKDFCNRYI 10 20 30 150 160 170 180 190 pF1KB4 ACLKTKMNSETLLSGEPGSPYSPVQ------SQQI----QSAITG-TISPQGIVVPASAL .::::::.:..:: .. :.:::: : ::.. ....: . .::::::::::: XP_016 TCLKTKMHSDNLLRNDLGGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASAL 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB4 QQGNVAMATV-----AGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQLQLQLNQDLSI ::::.::.:: .::..:::::.:: :::::::.. :.:.:::.:..:.:. :. XP_016 QQGNIAMTTVNSQVVSGGALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLT---SL 100 110 120 130 140 260 270 280 290 300 310 pF1KB4 LHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFI : ..: .::::::::::::::.::::::::. :::::::::.:::::::::::::::::: XP_016 LDNEDKKSKNKRGVLPKHATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFI 150 160 170 180 190 200 320 330 340 350 360 370 pF1KB4 NARRRILQPMLDSSCSE-TPKTKKKTAQNRPVQRFWPDSIASGVAQPPPSELTMSEGAVV ::::::::::::.: . .::.:: .:.::.:::::.:::.:: : ..:.. XP_016 NARRRILQPMLDASNPDPAPKAKKIKSQHRPTQRFWPNSIAAGVLQ--------QQGGAP 210 220 230 240 250 380 390 400 410 pF1KB4 TITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEED--------------- . ..:.:.:::::::.::.:.::.:::.. :.:.:.:::. XP_016 GTNPDGSINLDNLQSLSSDSATMAMQQAMMAAH--DDSLDGTEEEDEDEMEEEEEEELEE 260 270 280 290 300 310 420 430 pF1KB4 -AGALAPAHISGLVLENSDSLQ . : ...: : ::.::::. XP_016 EVDELQTTNVSDLGLEHSDSLE 320 330 >>XP_016873599 (OMIM: 613066) PREDICTED: homeobox protei (472 aa) initn: 1540 init1: 675 opt: 794 Z-score: 792.2 bits: 155.8 E(85289): 2.2e-37 Smith-Waterman score: 1650; 58.1% identity (79.1% similar) in 473 aa overlap (1-436:13-472) 10 20 30 40 pF1KB4 MMATQTLSIDSYQDGQQMQVVTELKTE-QDPNCSEPDAEGVSP-P--P :::::.. :::. :: .... .. : . : :.: . .: : : XP_016 MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVHISAPSAAASTPVPSAP 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB4 VESQTPMDVDKQAIYRHPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEG .. :. ...::.:.:::::::::.::::::::.::::: :::::::::::::..::.: XP_016 IDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITSASFDVDIENFVHQQEQEH 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB4 KPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEP :::: .::: :::::::::::::::::::::::::::::.:::.::::::.:..:: .. XP_016 KPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLLRNDL 130 140 150 160 170 180 170 180 190 200 pF1KB4 GSPYSPVQ------SQQI----QSAITG-TISPQGIVVPASALQQGNVAMATV-----AG :.:::: : ::.. ....: . .:::::::::::::::.::.:: .: XP_016 GGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSG 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB4 GTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQLQLQLNQDLSILHQDDGSSKNKRGVLPK :..:::::.:: :::::::.. :.:.:::.:..:.:. :.: ..: .:::::::::: XP_016 GALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLT---SLLDNEDKKSKNKRGVLPK 250 260 270 280 290 270 280 290 300 310 320 pF1KB4 HATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCSE ::::.::::::::. :::::::::.::::::::::::::::::::::::::::::.: . XP_016 HATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPD 300 310 320 330 340 350 330 340 350 360 370 380 pF1KB4 -TPKTKKKTAQNRPVQRFWPDSIASGVAQPPPSELTMSEGAVVTITTPVNMNVDSLQSLS .::.:: .:.::.:::::.:::.:: : ..:.. . ..:.:.::::: XP_016 PAPKAKKIKSQHRPTQRFWPNSIAAGVLQ--------QQGGAPGTNPDGSINLDNLQSLS 360 370 380 390 400 390 400 410 420 430 pF1KB4 SDGATLAVQQVMMAGQSEDESVDSTEED----------------AGALAPAHISGLVLEN ::.::.:.::.::: ..:.:.:.:::. . : ...: : ::. XP_016 SDSATMAMQQAMMA--AHDDSLDGTEEEDEDEMEEEEEEELEEEVDELQTTNVSDLGLEH 410 420 430 440 450 460 pF1KB4 SDSLQ ::::. XP_016 SDSLE 470 >>XP_011541247 (OMIM: 613066) PREDICTED: homeobox protei (472 aa) initn: 1540 init1: 675 opt: 794 Z-score: 792.2 bits: 155.8 E(85289): 2.2e-37 Smith-Waterman score: 1650; 58.1% identity (79.1% similar) in 473 aa overlap (1-436:13-472) 10 20 30 40 pF1KB4 MMATQTLSIDSYQDGQQMQVVTELKTE-QDPNCSEPDAEGVSP-P--P :::::.. :::. :: .... .. : . : :.: . .: : : XP_011 MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVHISAPSAAASTPVPSAP 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB4 VESQTPMDVDKQAIYRHPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEG .. :. ...::.:.:::::::::.::::::::.::::: :::::::::::::..::.: XP_011 IDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITSASFDVDIENFVHQQEQEH 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB4 KPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEP :::: .::: :::::::::::::::::::::::::::::.:::.::::::.:..:: .. XP_011 KPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLLRNDL 130 140 150 160 170 180 170 180 190 200 pF1KB4 GSPYSPVQ------SQQI----QSAITG-TISPQGIVVPASALQQGNVAMATV-----AG :.:::: : ::.. ....: . .:::::::::::::::.::.:: .: XP_011 GGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSG 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB4 GTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQLQLQLNQDLSILHQDDGSSKNKRGVLPK :..:::::.:: :::::::.. :.:.:::.:..:.:. :.: ..: .:::::::::: XP_011 GALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLT---SLLDNEDKKSKNKRGVLPK 250 260 270 280 290 270 280 290 300 310 320 pF1KB4 HATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCSE ::::.::::::::. :::::::::.::::::::::::::::::::::::::::::.: . XP_011 HATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPD 300 310 320 330 340 350 330 340 350 360 370 380 pF1KB4 -TPKTKKKTAQNRPVQRFWPDSIASGVAQPPPSELTMSEGAVVTITTPVNMNVDSLQSLS .::.:: .:.::.:::::.:::.:: : ..:.. . ..:.:.::::: XP_011 PAPKAKKIKSQHRPTQRFWPNSIAAGVLQ--------QQGGAPGTNPDGSINLDNLQSLS 360 370 380 390 400 390 400 410 420 430 pF1KB4 SDGATLAVQQVMMAGQSEDESVDSTEED----------------AGALAPAHISGLVLEN ::.::.:.::.::: ..:.:.:.:::. . : ...: : ::. XP_011 SDSATMAMQQAMMA--AHDDSLDGTEEEDEDEMEEEEEEELEEEVDELQTTNVSDLGLEH 410 420 430 440 450 460 pF1KB4 SDSLQ ::::. XP_011 SDSLE 470 >>NP_071345 (OMIM: 613066) homeobox protein PKNOX2 [Homo (472 aa) initn: 1540 init1: 675 opt: 794 Z-score: 792.2 bits: 155.8 E(85289): 2.2e-37 Smith-Waterman score: 1650; 58.1% identity (79.1% similar) in 473 aa overlap (1-436:13-472) 10 20 30 40 pF1KB4 MMATQTLSIDSYQDGQQMQVVTELKTE-QDPNCSEPDAEGVSP-P--P :::::.. :::. :: .... .. : . : :.: . .: : : NP_071 MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVHISAPSAAASTPVPSAP 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB4 VESQTPMDVDKQAIYRHPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEG .. :. ...::.:.:::::::::.::::::::.::::: :::::::::::::..::.: NP_071 IDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITSASFDVDIENFVHQQEQEH 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB4 KPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEP :::: .::: :::::::::::::::::::::::::::::.:::.::::::.:..:: .. NP_071 KPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLLRNDL 130 140 150 160 170 180 170 180 190 200 pF1KB4 GSPYSPVQ------SQQI----QSAITG-TISPQGIVVPASALQQGNVAMATV-----AG :.:::: : ::.. ....: . .:::::::::::::::.::.:: .: NP_071 GGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSG 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB4 GTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQLQLQLNQDLSILHQDDGSSKNKRGVLPK :..:::::.:: :::::::.. :.:.:::.:..:.:. :.: ..: .:::::::::: NP_071 GALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLT---SLLDNEDKKSKNKRGVLPK 250 260 270 280 290 270 280 290 300 310 320 pF1KB4 HATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCSE ::::.::::::::. :::::::::.::::::::::::::::::::::::::::::.: . NP_071 HATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPD 300 310 320 330 340 350 330 340 350 360 370 380 pF1KB4 -TPKTKKKTAQNRPVQRFWPDSIASGVAQPPPSELTMSEGAVVTITTPVNMNVDSLQSLS .::.:: .:.::.:::::.:::.:: : ..:.. . ..:.:.::::: NP_071 PAPKAKKIKSQHRPTQRFWPNSIAAGVLQ--------QQGGAPGTNPDGSINLDNLQSLS 360 370 380 390 400 390 400 410 420 430 pF1KB4 SDGATLAVQQVMMAGQSEDESVDSTEED----------------AGALAPAHISGLVLEN ::.::.:.::.::: ..:.:.:.:::. . : ...: : ::. NP_071 SDSATMAMQQAMMA--AHDDSLDGTEEEDEDEMEEEEEEELEEEVDELQTTNVSDLGLEH 410 420 430 440 450 460 pF1KB4 SDSLQ ::::. NP_071 SDSLE 470 >>XP_011541246 (OMIM: 613066) PREDICTED: homeobox protei (472 aa) initn: 1540 init1: 675 opt: 794 Z-score: 792.2 bits: 155.8 E(85289): 2.2e-37 Smith-Waterman score: 1650; 58.1% identity (79.1% similar) in 473 aa overlap (1-436:13-472) 10 20 30 40 pF1KB4 MMATQTLSIDSYQDGQQMQVVTELKTE-QDPNCSEPDAEGVSP-P--P :::::.. :::. :: .... .. : . : :.: . .: : : XP_011 MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVHISAPSAAASTPVPSAP 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB4 VESQTPMDVDKQAIYRHPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEG .. :. ...::.:.:::::::::.::::::::.::::: :::::::::::::..::.: XP_011 IDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITSASFDVDIENFVHQQEQEH 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB4 KPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEP :::: .::: :::::::::::::::::::::::::::::.:::.::::::.:..:: .. XP_011 KPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLLRNDL 130 140 150 160 170 180 170 180 190 200 pF1KB4 GSPYSPVQ------SQQI----QSAITG-TISPQGIVVPASALQQGNVAMATV-----AG :.:::: : ::.. ....: . .:::::::::::::::.::.:: .: XP_011 GGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSG 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB4 GTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQLQLQLNQDLSILHQDDGSSKNKRGVLPK :..:::::.:: :::::::.. :.:.:::.:..:.:. :.: ..: .:::::::::: XP_011 GALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLT---SLLDNEDKKSKNKRGVLPK 250 260 270 280 290 270 280 290 300 310 320 pF1KB4 HATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCSE ::::.::::::::. :::::::::.::::::::::::::::::::::::::::::.: . XP_011 HATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPD 300 310 320 330 340 350 330 340 350 360 370 380 pF1KB4 -TPKTKKKTAQNRPVQRFWPDSIASGVAQPPPSELTMSEGAVVTITTPVNMNVDSLQSLS .::.:: .:.::.:::::.:::.:: : ..:.. . ..:.:.::::: XP_011 PAPKAKKIKSQHRPTQRFWPNSIAAGVLQ--------QQGGAPGTNPDGSINLDNLQSLS 360 370 380 390 400 390 400 410 420 430 pF1KB4 SDGATLAVQQVMMAGQSEDESVDSTEED----------------AGALAPAHISGLVLEN ::.::.:.::.::: ..:.:.:.:::. . : ...: : ::. XP_011 SDSATMAMQQAMMA--AHDDSLDGTEEEDEDEMEEEEEEELEEEVDELQTTNVSDLGLEH 410 420 430 440 450 460 pF1KB4 SDSLQ ::::. XP_011 SDSLE 470 436 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 14:46:19 2016 done: Thu Nov 3 14:46:21 2016 Total Scan time: 9.990 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]