FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4367, 1124 aa 1>>>pF1KB4367 1124 - 1124 aa - 1124 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.4687+/-0.000509; mu= -9.2437+/- 0.032 mean_var=568.3573+/-120.540, 0's: 0 Z-trim(122.3): 1256 B-trim: 2090 in 1/55 Lambda= 0.053798 statistics sampled from 38421 (40102) to 38421 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.757), E-opt: 0.2 (0.47), width: 16 Scan time: 18.130 The best scores are: opt bits E(85289) NP_110378 (OMIM: 189909,609141,613270) zinc finger (1124) 7521 599.8 2.9e-170 NP_001167567 (OMIM: 189909,609141,613270) zinc fin (1125) 7501 598.3 8.5e-170 NP_001167565 (OMIM: 189909,609141,613270) zinc fin (1107) 7380 588.9 5.6e-167 NP_001310606 (OMIM: 189909,609141,613270) zinc fin (1110) 7380 588.9 5.7e-167 NP_001121600 (OMIM: 189909,609141,613270) zinc fin (1108) 7360 587.3 1.7e-166 NP_001310605 (OMIM: 189909,609141,613270) zinc fin (1111) 7360 587.3 1.7e-166 NP_001167566 (OMIM: 189909,609141,613270) zinc fin (1057) 6922 553.3 2.7e-156 NP_001167564 (OMIM: 189909,609141,613270) zinc fin (1104) 6813 544.9 1e-153 NP_001310607 (OMIM: 189909,609141,613270) zinc fin (1033) 6421 514.4 1.4e-144 NP_001310604 (OMIM: 189909,609141,613270) zinc fin (1036) 6421 514.4 1.4e-144 NP_001310603 (OMIM: 189909,609141,613270) zinc fin (1050) 6421 514.4 1.4e-144 NP_001310590 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310570 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310586 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310588 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310585 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310578 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310567 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310593 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310595 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310589 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310584 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310571 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 XP_016872086 (OMIM: 189909,609141,613270) PREDICTE ( 906) 6000 481.7 8.6e-135 NP_001310602 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 XP_006717561 (OMIM: 189909,609141,613270) PREDICTE ( 906) 6000 481.7 8.6e-135 XP_016872091 (OMIM: 189909,609141,613270) PREDICTE ( 906) 6000 481.7 8.6e-135 NP_001310601 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310579 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310577 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310592 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 XP_016872092 (OMIM: 189909,609141,613270) PREDICTE ( 906) 6000 481.7 8.6e-135 NP_001310576 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310594 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310575 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310583 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310582 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310574 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310591 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310581 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 XP_016872089 (OMIM: 189909,609141,613270) PREDICTE ( 906) 6000 481.7 8.6e-135 NP_001310572 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310573 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 XP_016872090 (OMIM: 189909,609141,613270) PREDICTE ( 906) 6000 481.7 8.6e-135 NP_001310580 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 NP_001310600 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 XP_016872087 (OMIM: 189909,609141,613270) PREDICTE ( 906) 6000 481.7 8.6e-135 XP_016872088 (OMIM: 189909,609141,613270) PREDICTE ( 906) 6000 481.7 8.6e-135 XP_011517945 (OMIM: 189909,609141,613270) PREDICTE ( 906) 6000 481.7 8.6e-135 NP_001310587 (OMIM: 189909,609141,613270) zinc fin ( 906) 6000 481.7 8.6e-135 >>NP_110378 (OMIM: 189909,609141,613270) zinc finger E-b (1124 aa) initn: 7521 init1: 7521 opt: 7521 Z-score: 3177.8 bits: 599.8 E(85289): 2.9e-170 Smith-Waterman score: 7521; 100.0% identity (100.0% similar) in 1124 aa overlap (1-1124:1-1124) 10 20 30 40 50 60 pF1KB4 MADGPRCKRRKQANPRRNNVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 MADGPRCKRRKQANPRRNNVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 LPTDQTVLPGRSSEREGNAKNCWEDDRKEGQEILGPEAQADEAGCTVKDDECESDAENEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 LPTDQTVLPGRSSEREGNAKNCWEDDRKEGQEILGPEAQADEAGCTVKDDECESDAENEQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 NHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 NHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGYK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 RFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 RFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 KCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 KCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 RPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 RPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 ASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 ASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 DGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 DGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 QPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 QPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB4 INALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 INALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYY 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB4 ALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 ALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNND 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB4 QPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 QPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB4 YTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 YTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB4 SCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 SCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQ 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB4 VAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 VAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB4 NGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 NGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPY 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB4 QCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 QCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQG 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB4 DSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 DSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEA 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 pF1KB4 ENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA :::::::::::::::::::::::::::::::::::::::::::: NP_110 ENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA 1090 1100 1110 1120 >>NP_001167567 (OMIM: 189909,609141,613270) zinc finger (1125 aa) initn: 6925 init1: 6925 opt: 7501 Z-score: 3169.4 bits: 598.3 E(85289): 8.5e-170 Smith-Waterman score: 7501; 99.8% identity (99.8% similar) in 1125 aa overlap (1-1124:1-1125) 10 20 30 40 50 60 pF1KB4 MADGPRCKRRKQANPRRNNVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MADGPRCKRRKQANPRRNNVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 LPTDQTVLPGRSSEREGNAKNCWEDDR-KEGQEILGPEAQADEAGCTVKDDECESDAENE :::::::::::::::::::::::::: :::::::::::::::::::::::::::::::: NP_001 LPTDQTVLPGRSSEREGNAKNCWEDDTGKEGQEILGPEAQADEAGCTVKDDECESDAENE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 QNHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QNHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB4 KRFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB4 FKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVN 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB4 GRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIV 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB4 VASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVA 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB4 VDGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSL 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB4 EQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPG 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB4 DINALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DINALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAY 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB4 YALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNN 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB4 DQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGY 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB4 LYTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQK 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB4 DSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIP 790 800 810 820 830 840 840 850 860 870 880 890 pF1KB4 QVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKT 850 860 870 880 890 900 900 910 920 930 940 950 pF1KB4 ENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKP 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KB4 YQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQ 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KB4 GDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEE 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 pF1KB4 AENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA ::::::::::::::::::::::::::::::::::::::::::::: NP_001 AENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA 1090 1100 1110 1120 >>NP_001167565 (OMIM: 189909,609141,613270) zinc finger (1107 aa) initn: 7380 init1: 7380 opt: 7380 Z-score: 3118.7 bits: 588.9 E(85289): 5.6e-167 Smith-Waterman score: 7380; 100.0% identity (100.0% similar) in 1105 aa overlap (20-1124:3-1107) 10 20 30 40 50 60 pF1KB4 MADGPRCKRRKQANPRRNNVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD ::::::::::::::::::::::::::::::::::::::::: NP_001 MKVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD 10 20 30 40 70 80 90 100 110 120 pF1KB4 LPTDQTVLPGRSSEREGNAKNCWEDDRKEGQEILGPEAQADEAGCTVKDDECESDAENEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPTDQTVLPGRSSEREGNAKNCWEDDRKEGQEILGPEAQADEAGCTVKDDECESDAENEQ 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB4 NHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGYK 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB4 RFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKF 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB4 KCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNG 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB4 RPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVV 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB4 ASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAV 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB4 DGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLE 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB4 QPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGD 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB4 INALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYY 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB4 ALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNND 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB4 QPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYL 650 660 670 680 690 700 730 740 750 760 770 780 pF1KB4 YTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKD 710 720 730 740 750 760 790 800 810 820 830 840 pF1KB4 SCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQ 770 780 790 800 810 820 850 860 870 880 890 900 pF1KB4 VAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTE 830 840 850 860 870 880 910 920 930 940 950 960 pF1KB4 NGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPY 890 900 910 920 930 940 970 980 990 1000 1010 1020 pF1KB4 QCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQG 950 960 970 980 990 1000 1030 1040 1050 1060 1070 1080 pF1KB4 DSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEA 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 pF1KB4 ENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA :::::::::::::::::::::::::::::::::::::::::::: NP_001 ENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA 1070 1080 1090 1100 >>NP_001310606 (OMIM: 189909,609141,613270) zinc finger (1110 aa) initn: 7380 init1: 7380 opt: 7380 Z-score: 3118.7 bits: 588.9 E(85289): 5.7e-167 Smith-Waterman score: 7380; 100.0% identity (100.0% similar) in 1105 aa overlap (20-1124:6-1110) 10 20 30 40 50 60 pF1KB4 MADGPRCKRRKQANPRRNNVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD ::::::::::::::::::::::::::::::::::::::::: NP_001 MATCAVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD 10 20 30 40 70 80 90 100 110 120 pF1KB4 LPTDQTVLPGRSSEREGNAKNCWEDDRKEGQEILGPEAQADEAGCTVKDDECESDAENEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPTDQTVLPGRSSEREGNAKNCWEDDRKEGQEILGPEAQADEAGCTVKDDECESDAENEQ 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB4 NHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGYK 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB4 RFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKF 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB4 KCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNG 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB4 RPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVV 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB4 ASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAV 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB4 DGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLE 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB4 QPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGD 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB4 INALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYY 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB4 ALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNND 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB4 QPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYL 650 660 670 680 690 700 730 740 750 760 770 780 pF1KB4 YTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKD 710 720 730 740 750 760 790 800 810 820 830 840 pF1KB4 SCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQ 770 780 790 800 810 820 850 860 870 880 890 900 pF1KB4 VAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTE 830 840 850 860 870 880 910 920 930 940 950 960 pF1KB4 NGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPY 890 900 910 920 930 940 970 980 990 1000 1010 1020 pF1KB4 QCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQG 950 960 970 980 990 1000 1030 1040 1050 1060 1070 1080 pF1KB4 DSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEA 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 pF1KB4 ENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA :::::::::::::::::::::::::::::::::::::::::::: NP_001 ENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA 1070 1080 1090 1100 1110 >>NP_001121600 (OMIM: 189909,609141,613270) zinc finger (1108 aa) initn: 6925 init1: 6925 opt: 7360 Z-score: 3110.3 bits: 587.3 E(85289): 1.7e-166 Smith-Waterman score: 7360; 99.8% identity (99.8% similar) in 1106 aa overlap (20-1124:3-1108) 10 20 30 40 50 60 pF1KB4 MADGPRCKRRKQANPRRNNVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD ::::::::::::::::::::::::::::::::::::::::: NP_001 MKVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD 10 20 30 40 70 80 90 100 110 pF1KB4 LPTDQTVLPGRSSEREGNAKNCWEDDR-KEGQEILGPEAQADEAGCTVKDDECESDAENE :::::::::::::::::::::::::: :::::::::::::::::::::::::::::::: NP_001 LPTDQTVLPGRSSEREGNAKNCWEDDTGKEGQEILGPEAQADEAGCTVKDDECESDAENE 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB4 QNHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QNHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGY 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB4 KRFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRK 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB4 FKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVN 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB4 GRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIV 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB4 VASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVA 350 360 370 380 390 400 420 430 440 450 460 470 pF1KB4 VDGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSL 410 420 430 440 450 460 480 490 500 510 520 530 pF1KB4 EQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPG 470 480 490 500 510 520 540 550 560 570 580 590 pF1KB4 DINALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DINALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAY 530 540 550 560 570 580 600 610 620 630 640 650 pF1KB4 YALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNN 590 600 610 620 630 640 660 670 680 690 700 710 pF1KB4 DQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGY 650 660 670 680 690 700 720 730 740 750 760 770 pF1KB4 LYTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQK 710 720 730 740 750 760 780 790 800 810 820 830 pF1KB4 DSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIP 770 780 790 800 810 820 840 850 860 870 880 890 pF1KB4 QVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKT 830 840 850 860 870 880 900 910 920 930 940 950 pF1KB4 ENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKP 890 900 910 920 930 940 960 970 980 990 1000 1010 pF1KB4 YQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQ 950 960 970 980 990 1000 1020 1030 1040 1050 1060 1070 pF1KB4 GDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEE 1010 1020 1030 1040 1050 1060 1080 1090 1100 1110 1120 pF1KB4 AENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA ::::::::::::::::::::::::::::::::::::::::::::: NP_001 AENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA 1070 1080 1090 1100 >>NP_001310605 (OMIM: 189909,609141,613270) zinc finger (1111 aa) initn: 6925 init1: 6925 opt: 7360 Z-score: 3110.3 bits: 587.3 E(85289): 1.7e-166 Smith-Waterman score: 7360; 99.8% identity (99.8% similar) in 1106 aa overlap (20-1124:6-1111) 10 20 30 40 50 60 pF1KB4 MADGPRCKRRKQANPRRNNVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD ::::::::::::::::::::::::::::::::::::::::: NP_001 MATCAVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD 10 20 30 40 70 80 90 100 110 pF1KB4 LPTDQTVLPGRSSEREGNAKNCWEDDR-KEGQEILGPEAQADEAGCTVKDDECESDAENE :::::::::::::::::::::::::: :::::::::::::::::::::::::::::::: NP_001 LPTDQTVLPGRSSEREGNAKNCWEDDTGKEGQEILGPEAQADEAGCTVKDDECESDAENE 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB4 QNHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QNHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGY 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB4 KRFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRK 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB4 FKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVN 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB4 GRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIV 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB4 VASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVA 350 360 370 380 390 400 420 430 440 450 460 470 pF1KB4 VDGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSL 410 420 430 440 450 460 480 490 500 510 520 530 pF1KB4 EQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPG 470 480 490 500 510 520 540 550 560 570 580 590 pF1KB4 DINALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DINALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAY 530 540 550 560 570 580 600 610 620 630 640 650 pF1KB4 YALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNN 590 600 610 620 630 640 660 670 680 690 700 710 pF1KB4 DQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGY 650 660 670 680 690 700 720 730 740 750 760 770 pF1KB4 LYTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQK 710 720 730 740 750 760 780 790 800 810 820 830 pF1KB4 DSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIP 770 780 790 800 810 820 840 850 860 870 880 890 pF1KB4 QVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKT 830 840 850 860 870 880 900 910 920 930 940 950 pF1KB4 ENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKP 890 900 910 920 930 940 960 970 980 990 1000 1010 pF1KB4 YQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQ 950 960 970 980 990 1000 1020 1030 1040 1050 1060 1070 pF1KB4 GDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEE 1010 1020 1030 1040 1050 1060 1080 1090 1100 1110 1120 pF1KB4 AENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA ::::::::::::::::::::::::::::::::::::::::::::: NP_001 AENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA 1070 1080 1090 1100 1110 >>NP_001167566 (OMIM: 189909,609141,613270) zinc finger (1057 aa) initn: 6920 init1: 6920 opt: 6922 Z-score: 2926.8 bits: 553.3 E(85289): 2.7e-156 Smith-Waterman score: 6922; 98.7% identity (99.2% similar) in 1055 aa overlap (70-1124:4-1057) 40 50 60 70 80 90 pF1KB4 HIVEEESVTDAADCEGVPEDDLPTDQTVLPGRSSEREGNAKNCWEDDRKEGQEILGPEAQ : .:. .: : ... :::::::::::: NP_001 MADGPRCKRRKQA-NPRRNNGKEGQEILGPEAQ 10 20 30 100 110 120 130 140 150 pF1KB4 ADEAGCTVKDDECESDAENEQNHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADEAGCTVKDDECESDAENEQNHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDE 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB4 NGTPDAFSQLLTCPYCDRGYKRFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGTPDAFSQLLTCPYCDRGYKRFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHM 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB4 TSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSHKSGRDQRHVTQSGCNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSH 160 170 180 190 200 210 280 290 300 310 320 330 pF1KB4 SGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGSYSSHISSKKCISLIPVNGRPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQE 220 230 240 250 260 270 340 350 360 370 380 390 pF1KB4 QLSVNQIKTEPVDYEFKPIVVASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLSVNQIKTEPVDYEFKPIVVASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTV 280 290 300 310 320 330 400 410 420 430 440 450 pF1KB4 GLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLVSPISINLSDIQNVLKVAVDGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISA 340 350 360 370 380 390 460 470 480 490 500 510 pF1KB4 ISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISLPLVDQDGTTKIIINYSLEQPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKD 400 410 420 430 440 450 520 530 540 550 560 570 pF1KB4 KSFEGGVNDSTCLLCDDCPGDINALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSFEGGVNDSTCLLCDDCPGDINALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGD 460 470 480 490 500 510 580 590 600 610 620 630 pF1KB4 GNLSPSQPPLKNLLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNLSPSQPPLKNLLSLLKAYYALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISV 520 530 540 550 560 570 640 650 660 670 680 690 pF1KB4 QSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSSEPSSPEPGKVNIPAKNNDQPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSR 580 590 600 610 620 630 700 710 720 730 740 750 pF1KB4 SSTPSPSPLNLSSSRNTQGYLYTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSTPSPSPLNLSSSRNTQGYLYTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNS 640 650 660 670 680 690 760 770 780 790 800 810 pF1KB4 VYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VYSVQEEPLNLSCAKKEPQKDSCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIAD 700 710 720 730 740 750 820 830 840 850 860 870 pF1KB4 QNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QNSVPCLRALAANKQTILIPQVAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVS 760 770 780 790 800 810 880 890 900 910 920 930 pF1KB4 NVEDQNDSDSTPPKKKMRKTENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NVEDQNDSDSTPPKKKMRKTENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKK 820 830 840 850 860 870 940 950 960 970 980 990 pF1KB4 AFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQE 880 890 900 910 920 930 1000 1010 1020 1030 1040 1050 pF1KB4 EAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKP 940 950 960 970 980 990 1060 1070 1080 1090 1100 1110 pF1KB4 QGDEEEEEEEEEVEEEEVEEAENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGDEEEEEEEEEVEEEEVEEAENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEE 1000 1010 1020 1030 1040 1050 1120 pF1KB4 KTNEA ::::: NP_001 KTNEA >>NP_001167564 (OMIM: 189909,609141,613270) zinc finger (1104 aa) initn: 6789 init1: 6789 opt: 6813 Z-score: 2880.9 bits: 544.9 E(85289): 1e-153 Smith-Waterman score: 7334; 98.1% identity (98.2% similar) in 1124 aa overlap (1-1124:1-1104) 10 20 30 40 50 60 pF1KB4 MADGPRCKRRKQANPRRNNVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MADGPRCKRRKQANPRRNNVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 LPTDQTVLPGRSSEREGNAKNCWEDDRKEGQEILGPEAQADEAGCTVKDDECESDAENEQ :::::::::::::::::::::::::: .::::::::::::: NP_001 LPTDQTVLPGRSSEREGNAKNCWEDD--------------------IKDDECESDAENEQ 70 80 90 100 130 140 150 160 170 180 pF1KB4 NHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGYK 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB4 RFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKF 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB4 KCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNG 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB4 RPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVV 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB4 ASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAV 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB4 DGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLE 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB4 QPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGD 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB4 INALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYY 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB4 ALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNND 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB4 QPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYL 650 660 670 680 690 700 730 740 750 760 770 780 pF1KB4 YTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKD 710 720 730 740 750 760 790 800 810 820 830 840 pF1KB4 SCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQ 770 780 790 800 810 820 850 860 870 880 890 900 pF1KB4 VAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTE 830 840 850 860 870 880 910 920 930 940 950 960 pF1KB4 NGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPY 890 900 910 920 930 940 970 980 990 1000 1010 1020 pF1KB4 QCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQG 950 960 970 980 990 1000 1030 1040 1050 1060 1070 1080 pF1KB4 DSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEA 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 pF1KB4 ENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA :::::::::::::::::::::::::::::::::::::::::::: NP_001 ENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA 1070 1080 1090 1100 >>NP_001310607 (OMIM: 189909,609141,613270) zinc finger (1033 aa) initn: 6410 init1: 6410 opt: 6421 Z-score: 2716.8 bits: 514.4 E(85289): 1.4e-144 Smith-Waterman score: 6710; 93.3% identity (93.3% similar) in 1105 aa overlap (20-1124:3-1033) 10 20 30 40 50 60 pF1KB4 MADGPRCKRRKQANPRRNNVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD ::::::::::::::::::::::::::::::::::::::::: NP_001 MKVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD 10 20 30 40 70 80 90 100 110 120 pF1KB4 LPTDQTVLPGRSSEREGNAKNCWEDDRKEGQEILGPEAQADEAGCTVKDDECESDAENEQ ::::::::::::::::::::::::::: NP_001 LPTDQTVLPGRSSEREGNAKNCWEDDR--------------------------------- 50 60 70 130 140 150 160 170 180 pF1KB4 NHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGYK ::::::::::::::::::: NP_001 -----------------------------------------TPDAFSQLLTCPYCDRGYK 80 190 200 210 220 230 240 pF1KB4 RFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKF 90 100 110 120 130 140 250 260 270 280 290 300 pF1KB4 KCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNG 150 160 170 180 190 200 310 320 330 340 350 360 pF1KB4 RPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVV 210 220 230 240 250 260 370 380 390 400 410 420 pF1KB4 ASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAV 270 280 290 300 310 320 430 440 450 460 470 480 pF1KB4 DGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLE 330 340 350 360 370 380 490 500 510 520 530 540 pF1KB4 QPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGD 390 400 410 420 430 440 550 560 570 580 590 600 pF1KB4 INALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYY 450 460 470 480 490 500 610 620 630 640 650 660 pF1KB4 ALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNND 510 520 530 540 550 560 670 680 690 700 710 720 pF1KB4 QPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYL 570 580 590 600 610 620 730 740 750 760 770 780 pF1KB4 YTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKD 630 640 650 660 670 680 790 800 810 820 830 840 pF1KB4 SCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQ 690 700 710 720 730 740 850 860 870 880 890 900 pF1KB4 VAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTE 750 760 770 780 790 800 910 920 930 940 950 960 pF1KB4 NGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPY 810 820 830 840 850 860 970 980 990 1000 1010 1020 pF1KB4 QCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQG 870 880 890 900 910 920 1030 1040 1050 1060 1070 1080 pF1KB4 DSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEA 930 940 950 960 970 980 1090 1100 1110 1120 pF1KB4 ENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA :::::::::::::::::::::::::::::::::::::::::::: NP_001 ENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA 990 1000 1010 1020 1030 >>NP_001310604 (OMIM: 189909,609141,613270) zinc finger (1036 aa) initn: 6410 init1: 6410 opt: 6421 Z-score: 2716.8 bits: 514.4 E(85289): 1.4e-144 Smith-Waterman score: 6710; 93.3% identity (93.3% similar) in 1105 aa overlap (20-1124:6-1036) 10 20 30 40 50 60 pF1KB4 MADGPRCKRRKQANPRRNNVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD ::::::::::::::::::::::::::::::::::::::::: NP_001 MATCAVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD 10 20 30 40 70 80 90 100 110 120 pF1KB4 LPTDQTVLPGRSSEREGNAKNCWEDDRKEGQEILGPEAQADEAGCTVKDDECESDAENEQ ::::::::::::::::::::::::::: NP_001 LPTDQTVLPGRSSEREGNAKNCWEDDR--------------------------------- 50 60 70 130 140 150 160 170 180 pF1KB4 NHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGYK ::::::::::::::::::: NP_001 -----------------------------------------TPDAFSQLLTCPYCDRGYK 80 90 190 200 210 220 230 240 pF1KB4 RFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKF 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB4 KCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNG 160 170 180 190 200 210 310 320 330 340 350 360 pF1KB4 RPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVV 220 230 240 250 260 270 370 380 390 400 410 420 pF1KB4 ASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAV 280 290 300 310 320 330 430 440 450 460 470 480 pF1KB4 DGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLE 340 350 360 370 380 390 490 500 510 520 530 540 pF1KB4 QPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGD 400 410 420 430 440 450 550 560 570 580 590 600 pF1KB4 INALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYY 460 470 480 490 500 510 610 620 630 640 650 660 pF1KB4 ALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNND 520 530 540 550 560 570 670 680 690 700 710 720 pF1KB4 QPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYL 580 590 600 610 620 630 730 740 750 760 770 780 pF1KB4 YTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKD 640 650 660 670 680 690 790 800 810 820 830 840 pF1KB4 SCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQ 700 710 720 730 740 750 850 860 870 880 890 900 pF1KB4 VAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTE 760 770 780 790 800 810 910 920 930 940 950 960 pF1KB4 NGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPY 820 830 840 850 860 870 970 980 990 1000 1010 1020 pF1KB4 QCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASPSQG 880 890 900 910 920 930 1030 1040 1050 1060 1070 1080 pF1KB4 DSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEEA 940 950 960 970 980 990 1090 1100 1110 1120 pF1KB4 ENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA :::::::::::::::::::::::::::::::::::::::::::: NP_001 ENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA 1000 1010 1020 1030 1124 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 14:50:38 2016 done: Thu Nov 3 14:50:40 2016 Total Scan time: 18.130 Total Display time: 0.610 Function used was FASTA [36.3.4 Apr, 2011]