Result of FASTA (omim) for
pF1KB4387
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4387, 858 aa
1>>>pF1KB4387 858 - 858 aa - 858 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.1687+/-0.00064; mu= 12.2901+/- 0.039
mean_var=219.5644+/-45.556, 0's: 0 Z-trim(113.0): 451 B-trim: 980 in 1/50
Lambda= 0.086555
statistics sampled from 21636 (22186) to 21636 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.602), E-opt: 0.2 (0.26), width: 16
Scan time: 12.580
The best scores are: opt bits E(85289)
NP_001182727 (OMIM: 143890,606945) low-density lip ( 858) 6168 784.9 0
NP_000518 (OMIM: 143890,606945) low-density lipopr ( 860) 6154 783.2 0
XP_011526312 (OMIM: 143890,606945) PREDICTED: low- ( 834) 5581 711.6 3.8e-204
NP_001182728 (OMIM: 143890,606945) low-density lip ( 819) 5460 696.5 1.3e-199
NP_001182729 (OMIM: 143890,606945) low-density lip ( 692) 4259 546.4 1.7e-154
NP_001182732 (OMIM: 143890,606945) low-density lip ( 682) 3266 422.4 3.5e-117
NP_003374 (OMIM: 192977,224050) very low-density l ( 873) 2970 385.6 5.5e-106
NP_001309154 (OMIM: 192977,224050) very low-densit ( 832) 2947 382.7 3.9e-105
NP_001018066 (OMIM: 192977,224050) very low-densit ( 845) 2938 381.6 8.6e-105
NP_001309155 (OMIM: 192977,224050) very low-densit ( 804) 2915 378.7 6.1e-104
NP_001018064 (OMIM: 602600,608446) low-density lip ( 904) 2548 332.9 4.1e-90
NP_004622 (OMIM: 602600,608446) low-density lipopr ( 963) 2548 332.9 4.2e-90
XP_005271232 (OMIM: 602600,608446) PREDICTED: low- ( 834) 2290 300.6 1.9e-80
NP_059992 (OMIM: 602600,608446) low-density lipopr ( 700) 2270 298.0 9.8e-80
NP_150643 (OMIM: 602600,608446) low-density lipopr ( 793) 2149 283.0 3.8e-75
XP_016857754 (OMIM: 602600,608446) PREDICTED: low- ( 921) 2125 280.1 3.3e-74
XP_005271231 (OMIM: 602600,608446) PREDICTED: low- ( 847) 1991 263.3 3.4e-69
XP_006710944 (OMIM: 602600,608446) PREDICTED: low- ( 917) 1941 257.1 2.7e-67
XP_005271230 (OMIM: 602600,608446) PREDICTED: low- ( 976) 1941 257.1 2.8e-67
XP_016857755 (OMIM: 602600,608446) PREDICTED: low- ( 842) 1921 254.6 1.4e-66
XP_006710945 (OMIM: 602600,608446) PREDICTED: low- ( 901) 1921 254.6 1.5e-66
XP_011540398 (OMIM: 602600,608446) PREDICTED: low- ( 762) 1916 253.9 2.1e-66
XP_011540397 (OMIM: 602600,608446) PREDICTED: low- ( 804) 1864 247.4 2e-64
XP_016859830 (OMIM: 608766) PREDICTED: low-density (4469) 1837 245.0 5.9e-63
NP_061027 (OMIM: 608766) low-density lipoprotein r (4599) 1837 245.0 6e-63
XP_011540396 (OMIM: 602600,608446) PREDICTED: low- ( 934) 1657 221.6 1.3e-56
XP_016857756 (OMIM: 602600,608446) PREDICTED: low- ( 557) 1432 193.3 2.7e-48
XP_016857757 (OMIM: 602600,608446) PREDICTED: low- ( 557) 1432 193.3 2.7e-48
XP_011509485 (OMIM: 222448,600073) PREDICTED: low- (4612) 1090 151.7 7.2e-35
XP_011509486 (OMIM: 222448,600073) PREDICTED: low- (3892) 1050 146.6 2.1e-33
NP_004516 (OMIM: 222448,600073) low-density lipopr (4655) 1050 146.7 2.3e-33
XP_016863342 (OMIM: 131530,611718) PREDICTED: pro- ( 934) 802 114.9 1.8e-24
XP_016863340 (OMIM: 131530,611718) PREDICTED: pro- (1060) 802 114.9 1.9e-24
XP_016863339 (OMIM: 131530,611718) PREDICTED: pro- (1141) 802 115.0 2e-24
XP_016863338 (OMIM: 131530,611718) PREDICTED: pro- (1142) 802 115.0 2e-24
NP_001171601 (OMIM: 131530,611718) pro-epidermal g (1166) 802 115.0 2.1e-24
XP_011530009 (OMIM: 131530,611718) PREDICTED: pro- (1178) 802 115.0 2.1e-24
XP_016863336 (OMIM: 131530,611718) PREDICTED: pro- (1182) 802 115.0 2.1e-24
NP_001954 (OMIM: 131530,611718) pro-epidermal grow (1207) 802 115.0 2.1e-24
XP_016863335 (OMIM: 131530,611718) PREDICTED: pro- (1215) 802 115.0 2.1e-24
XP_005262853 (OMIM: 131530,611718) PREDICTED: pro- (1215) 802 115.0 2.1e-24
XP_016863334 (OMIM: 131530,611718) PREDICTED: pro- (1223) 802 115.0 2.1e-24
XP_016863341 (OMIM: 131530,611718) PREDICTED: pro- (1010) 799 114.5 2.4e-24
NP_001171602 (OMIM: 131530,611718) pro-epidermal g (1165) 799 114.6 2.7e-24
XP_016863337 (OMIM: 131530,611718) PREDICTED: pro- (1181) 799 114.6 2.7e-24
XP_011518406 (OMIM: 212780,604270,614305,616304) P (1160) 743 107.6 3.4e-22
XP_011518405 (OMIM: 212780,604270,614305,616304) P (1637) 743 107.8 4.2e-22
XP_016873223 (OMIM: 212780,604270,614305,616304) P (1809) 743 107.9 4.5e-22
NP_002325 (OMIM: 212780,604270,614305,616304) low- (1905) 743 107.9 4.6e-22
XP_011518973 (OMIM: 603507,610947,616724) PREDICTE (1462) 741 107.5 4.6e-22
>>NP_001182727 (OMIM: 143890,606945) low-density lipopro (858 aa)
initn: 6168 init1: 6168 opt: 6168 Z-score: 4182.1 bits: 784.9 E(85289): 0
Smith-Waterman score: 6168; 100.0% identity (100.0% similar) in 858 aa overlap (1-858:1-858)
10 20 30 40 50 60
pF1KB4 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB4 VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB4 KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB4 DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB4 PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB4 TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB4 EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH
790 800 810 820 830 840
850
pF1KB4 NQDGYSYPSMVSLEDDVA
::::::::::::::::::
NP_001 NQDGYSYPSMVSLEDDVA
850
>>NP_000518 (OMIM: 143890,606945) low-density lipoprotei (860 aa)
initn: 6114 init1: 6114 opt: 6154 Z-score: 4172.7 bits: 783.2 E(85289): 0
Smith-Waterman score: 6154; 99.8% identity (99.8% similar) in 860 aa overlap (1-858:1-860)
10 20 30 40 50 60
pF1KB4 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB4 VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB4 KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB4 DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB4 PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB4 TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB4 EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH
790 800 810 820 830 840
850
pF1KB4 NQDGYSYPS--MVSLEDDVA
::::::::: :::::::::
NP_000 NQDGYSYPSRQMVSLEDDVA
850 860
>>XP_011526312 (OMIM: 143890,606945) PREDICTED: low-dens (834 aa)
initn: 5957 init1: 5581 opt: 5581 Z-score: 3786.1 bits: 711.6 E(85289): 3.8e-204
Smith-Waterman score: 5931; 96.7% identity (96.7% similar) in 860 aa overlap (1-858:1-834)
10 20 30 40 50 60
pF1KB4 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB4 VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB4 KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB4 DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB4 PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB4 TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQ----------
730 740 750 760 770
790 800 810 820 830 840
pF1KB4 EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH
::::::::::::::::::::::::::::::::::::::::::::
XP_011 ----------------VLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH
780 790 800 810
850
pF1KB4 NQDGYSYPS--MVSLEDDVA
::::::::: :::::::::
XP_011 NQDGYSYPSRQMVSLEDDVA
820 830
>>NP_001182728 (OMIM: 143890,606945) low-density lipopro (819 aa)
initn: 5317 init1: 5317 opt: 5460 Z-score: 3704.5 bits: 696.5 E(85289): 1.3e-199
Smith-Waterman score: 5726; 94.9% identity (94.9% similar) in 860 aa overlap (1-858:1-819)
10 20 30 40 50 60
pF1KB4 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK
::: :::::::::::::::
NP_001 ETC-----------------------------------------SPKTCSQDEFRCHDGK
70
130 140 150 160 170 180
pF1KB4 CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW
80 90 100 110 120 130
190 200 210 220 230 240
pF1KB4 PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE
140 150 160 170 180 190
250 260 270 280 290 300
pF1KB4 FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR
200 210 220 230 240 250
310 320 330 340 350 360
pF1KB4 DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD
260 270 280 290 300 310
370 380 390 400 410 420
pF1KB4 PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT
320 330 340 350 360 370
430 440 450 460 470 480
pF1KB4 SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA
380 390 400 410 420 430
490 500 510 520 530 540
pF1KB4 VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA
440 450 460 470 480 490
550 560 570 580 590 600
pF1KB4 KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE
500 510 520 530 540 550
610 620 630 640 650 660
pF1KB4 DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ
560 570 580 590 600 610
670 680 690 700 710 720
pF1KB4 PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA
620 630 640 650 660 670
730 740 750 760 770 780
pF1KB4 TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN
680 690 700 710 720 730
790 800 810 820 830 840
pF1KB4 EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH
740 750 760 770 780 790
850
pF1KB4 NQDGYSYPS--MVSLEDDVA
::::::::: :::::::::
NP_001 NQDGYSYPSRQMVSLEDDVA
800 810
>>NP_001182729 (OMIM: 143890,606945) low-density lipopro (692 aa)
initn: 3983 init1: 3983 opt: 4259 Z-score: 2894.8 bits: 546.4 E(85289): 1.7e-154
Smith-Waterman score: 4478; 80.1% identity (80.2% similar) in 860 aa overlap (1-858:1-692)
10 20 30 40 50 60
pF1KB4 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK
::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGC----------------
70 80 90 100
130 140 150 160 170 180
pF1KB4 CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW
NP_001 ------------------------------------------------------------
190 200 210 220 230 240
pF1KB4 PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE
NP_001 ------------------------------------------------------------
250 260 270 280 290 300
pF1KB4 FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR
.:::::::::::::::::::::::::::
NP_001 --------------------------------LTLCEGPNKFKCHSGECITLDKVCNMAR
110 120 130
310 320 330 340 350 360
pF1KB4 DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD
140 150 160 170 180 190
370 380 390 400 410 420
pF1KB4 PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT
200 210 220 230 240 250
430 440 450 460 470 480
pF1KB4 SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA
260 270 280 290 300 310
490 500 510 520 530 540
pF1KB4 VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA
320 330 340 350 360 370
550 560 570 580 590 600
pF1KB4 KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE
380 390 400 410 420 430
610 620 630 640 650 660
pF1KB4 DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ
440 450 460 470 480 490
670 680 690 700 710 720
pF1KB4 PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA
500 510 520 530 540 550
730 740 750 760 770 780
pF1KB4 TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN
560 570 580 590 600 610
790 800 810 820 830 840
pF1KB4 EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH
620 630 640 650 660 670
850
pF1KB4 NQDGYSYPS--MVSLEDDVA
::::::::: :::::::::
NP_001 NQDGYSYPSRQMVSLEDDVA
680 690
>>NP_001182732 (OMIM: 143890,606945) low-density lipopro (682 aa)
initn: 4007 init1: 3138 opt: 3266 Z-score: 2224.8 bits: 422.4 E(85289): 3.5e-117
Smith-Waterman score: 4384; 79.1% identity (79.1% similar) in 860 aa overlap (1-858:1-682)
10 20 30 40 50 60
pF1KB4 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCP---------------
70 80 90 100
130 140 150 160 170 180
pF1KB4 CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW
NP_001 ------------------------------------------------------------
190 200 210 220 230 240
pF1KB4 PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE
::::::::
NP_001 ----------------------------------------------------VATCRPDE
110
250 260 270 280 290 300
pF1KB4 FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR
120 130 140 150 160 170
310 320 330 340 350 360
pF1KB4 DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD
180 190 200 210 220 230
370 380 390 400 410 420
pF1KB4 PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT
240 250 260 270 280 290
430 440 450 460 470 480
pF1KB4 SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA
300 310 320 330 340 350
490 500 510 520 530 540
pF1KB4 VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA
360 370 380 390 400 410
550 560 570 580 590 600
pF1KB4 KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE
420 430 440 450 460 470
610 620 630 640 650 660
pF1KB4 DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ
480 490 500 510 520 530
670 680 690 700 710 720
pF1KB4 PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA
:: :::::::
NP_001 PR---------------------------------------------------EAEAAVA
540
730 740 750 760 770 780
pF1KB4 TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN
550 560 570 580 590 600
790 800 810 820 830 840
pF1KB4 EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH
610 620 630 640 650 660
850
pF1KB4 NQDGYSYPS--MVSLEDDVA
::::::::: :::::::::
NP_001 NQDGYSYPSRQMVSLEDDVA
670 680
>>NP_003374 (OMIM: 192977,224050) very low-density lipop (873 aa)
initn: 2751 init1: 1284 opt: 2970 Z-score: 2023.8 bits: 385.6 E(85289): 5.5e-106
Smith-Waterman score: 3139; 50.6% identity (75.5% similar) in 842 aa overlap (23-858:68-873)
10 20 30 40 50
pF1KB4 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAEC
: : ...: :..:.:. .: :::. .:
NP_003 FQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDC
40 50 60 70 80 90
60 70 80 90 100 110
pF1KB4 QDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQD
.:::::: : : ::. ..:::.. ..::: :::::. :::.: ::..: ::: :
NP_003 EDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPD
100 110 120 130 140 150
120 130 140 150 160 170
pF1KB4 EFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPD
:: : .:.::::.:::... :: ::::: .: ::: :::..:.::: :.::.: :
NP_003 EFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDAD
160 170 180 190 200 210
180 190 200 210 220 230
pF1KB4 CEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCA
: : ::: ..: :.. . : : :..: ::::::..::::: ::::: ::: ::
NP_003 CSDQSDESLEQCGRQPVIH---TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP
220 230 240 250 260 270
240 250 260 270 280 290
pF1KB4 VATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITL
:::::.:.: ::.::::::::. :: : ::::.: ::. : ::.::::.::::: .
NP_003 SRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDI
280 290 300 310 320 330
300 310 320 330 340 350
pF1KB4 DKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRC
.::::. .:::::::::.::: :::: :::::::.:.:: ::::: : ::.:. .. :
NP_003 SKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTC
340 350 360 370 380 390
360 370 380 390 400 410
pF1KB4 EDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKM
::::::.: :::.:.::.:::::.: .:.:.: : .:::::. :.::::...::.
NP_003 GDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKI
400 410 420 430 440 450
420 430 440 450 460 470
pF1KB4 TLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRD
:.:.:: .:. .:::.::::...:.....:.::::. : :...: :. . .:. .
NP_003 GLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK--VGRHVKMID-N
460 470 480 490 500 510
480 490 500 510 520 530
pF1KB4 IQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMY
. : ..::::....:::::.. :.::: :.::: :: . .: .:.:::. ::.:
NP_003 VYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVY
520 530 540 550 560 570
540 550 560 570 580 590
pF1KB4 WTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNG
:.::: ::::.:.:.:: : ::: .:::::::::::...::::.::::: .::.:.::
NP_003 WSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNG
580 590 600 610 620 630
600 610 620 630 640 650
pF1KB4 GNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDM
.:. .:.. . ::::..:..:::.:.: : :::...::..:::.. :..:: . .:.
NP_003 QDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDI
640 650 660 670 680 690
660 670 680 690 700 710
pF1KB4 VLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCL
...:.:.:: : ::::. . ::::.:::::::::: ::::.::.::.:. . .. :.:
NP_003 IVYHELVQPSGKNWCEED-MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC-
700 710 720 730 740
720 730 740 750 760 770
pF1KB4 TEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQAL
: :.: . : .:. :.: . :: : .:: ....: :.
NP_003 ---------QSTAT-----TVTYSETKDTNTTEISATS---GLVPG--GINVTT----AV
750 760 770 780
780 790 800 810 820 830
pF1KB4 GDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTT
..:. :... : .::..:::. .: .:.:.::. ::..:.::::::: :::
NP_003 SEVS-----VPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTT
790 800 810 820 830 840
840 850
pF1KB4 EDEVHIC---HNQD-GYSYP--SMVSLEDDVA
:... : :. . :..:: :.:: .::.:
NP_003 EEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
850 860 870
>>NP_001309154 (OMIM: 192977,224050) very low-density li (832 aa)
initn: 2434 init1: 1284 opt: 2947 Z-score: 2008.5 bits: 382.7 E(85289): 3.9e-105
Smith-Waterman score: 3116; 49.9% identity (74.8% similar) in 866 aa overlap (10-858:7-832)
10 20 30 40 50
pF1KB4 MGPWGWKLRWTVALLLA---------AAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAE
:.. :::: :.::. .:: ..::: .:.::. : :::. .
NP_001 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDED
10 20 30 40 50
60 70 80 90 100
pF1KB4 CQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDE--QGCPPKTC
: ::::: ..:.. :: .:: :.. ..:.:. :.:::. ::..:::: . : ::
NP_001 CVDGSDE--KNCVKKTCAESDFVCNN--GQCVPSRWKCDGDPDCEDGSDESPEQCRNITC
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB4 SQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDN
: ::: : .:.::::.:::... :: ::::: .: ::: :::..:.::: :.::.
NP_001 SPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDD
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB4 DPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEE
: :: : ::: ..: :.. . : : :..: ::::::..::::: ::::: :::
NP_001 DADCSDQSDESLEQCGRQPVIH---TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEV
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB4 NCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGEC
:: :::::.:.: ::.::::::::. :: : ::::.: ::. : ::.::::.::::
NP_001 NCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGEC
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB4 ITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQ
: ..::::. .:::::::::.::: :::: :::::::.:.:: ::::: : ::.:. .
NP_001 IDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDR
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB4 RRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEV
. : ::::::.: :::.:.::.:::::.: .:.:.: : .:::::. :.::::...
NP_001 KTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDI
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB4 RKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVI
::. :.:.:: .:. .:::.::::...:.....:.::::. : :...: :. . .:
NP_001 RKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK--VGRHVKMI
420 430 440 450 460
470 480 490 500 510 520
pF1KB4 SRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHG
. .. : ..::::....:::::.. :.::: :.::: :: . .: .:.:::. :
NP_001 D-NVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSG
470 480 490 500 510 520
530 540 550 560 570 580
pF1KB4 FMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSID
:.::.::: ::::.:.:.:: : ::: .:::::::::::...::::.::::: .::.:
NP_001 FVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVD
530 540 550 560 570 580
590 600 610 620 630 640
pF1KB4 VNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSP
.:: .:. .:.. . ::::..:..:::.:.: : :::...::..:::.. :..:: .
NP_001 LNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDA
590 600 610 620 630 640
650 660 670 680 690 700
pF1KB4 EDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMR
.:....:.:.:: : ::::. . ::::.:::::::::: ::::.::.::.:. . .. :
NP_001 QDIIVYHELVQPSGKNWCEED-MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGR
650 660 670 680 690 700
710 720 730 740 750 760
pF1KB4 SCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSH
.: : :.: . : .:. :.: . :: : .:: ....:
NP_001 DC----------QSTAT-----TVTYSETKDTNTTEISATS---GLVPG--GINVTT---
710 720 730 740
770 780 790 800 810 820
pF1KB4 QALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQ
:...:. :... : .::..:::. .: .:.:.::. ::..:.:::::::
NP_001 -AVSEVS-----VPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYL
750 760 770 780 790
830 840 850
pF1KB4 KTTEDEVHIC---HNQD-GYSYP--SMVSLEDDVA
::::... : :. . :..:: :.:: .::.:
NP_001 KTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
800 810 820 830
>>NP_001018066 (OMIM: 192977,224050) very low-density li (845 aa)
initn: 2755 init1: 1284 opt: 2938 Z-score: 2002.4 bits: 381.6 E(85289): 8.6e-105
Smith-Waterman score: 3056; 49.6% identity (73.3% similar) in 842 aa overlap (23-858:68-845)
10 20 30 40 50
pF1KB4 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAEC
: : ...: :..:.:. .: :::. .:
NP_001 FQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDC
40 50 60 70 80 90
60 70 80 90 100 110
pF1KB4 QDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQD
.:::::: : : ::. ..:::.. ..::: :::::. :::.: ::..: ::: :
NP_001 EDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPD
100 110 120 130 140 150
120 130 140 150 160 170
pF1KB4 EFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPD
:: : .:.::::.:::... :: ::::: .: ::: :::..:.::: :.::.: :
NP_001 EFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDAD
160 170 180 190 200 210
180 190 200 210 220 230
pF1KB4 CEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCA
: : ::: ..: :.. . : : :..: ::::::..::::: ::::: ::: ::
NP_001 CSDQSDESLEQCGRQPVIH---TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP
220 230 240 250 260 270
240 250 260 270 280 290
pF1KB4 VATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITL
:::::.:.: ::.::::::::. :: : ::::.: ::. : ::.::::.::::: .
NP_001 SRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDI
280 290 300 310 320 330
300 310 320 330 340 350
pF1KB4 DKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRC
.::::. .:::::::::.::: :::: :::::::.:.:: ::::: : ::.:. .. :
NP_001 SKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTC
340 350 360 370 380 390
360 370 380 390 400 410
pF1KB4 EDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKM
::::::.: :::.:.::.:::::.: .:.:.: : .:::::. :.::::...::.
NP_001 GDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKI
400 410 420 430 440 450
420 430 440 450 460 470
pF1KB4 TLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRD
:.:.:: .:. .:::.::::...:.....:.::::. : :...: :. . .:. .
NP_001 GLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK--VGRHVKMID-N
460 470 480 490 500 510
480 490 500 510 520 530
pF1KB4 IQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMY
. : ..::::....:::::.. :.::: :.::: :: . .: .:.:::. ::.:
NP_001 VYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVY
520 530 540 550 560 570
540 550 560 570 580 590
pF1KB4 WTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNG
:.::: ::::.:.:.:: : ::: .:::::::::::...::::.::::: .::.:.::
NP_001 WSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNG
580 590 600 610 620 630
600 610 620 630 640 650
pF1KB4 GNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDM
.:. .:.. . ::::..:..:::.:.: : :::...::..:::.. :..:: . .:.
NP_001 QDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDI
640 650 660 670 680 690
660 670 680 690 700 710
pF1KB4 VLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCL
...:.:.:: : ::::. . ::::.:::::::::: ::::.::.::.:. . .. :.:
NP_001 IVYHELVQPSGKNWCEED-MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQ
700 710 720 730 740 750
720 730 740 750 760 770
pF1KB4 TEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQAL
:..:. ::: . ::
NP_001 ---------------RINVT-TAV-----SEVSVP-------------------------
760
780 790 800 810 820 830
pF1KB4 GDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTT
:... : .::..:::. .: .:.:.::. ::..:.::::::: :::
NP_001 -----------PKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTT
770 780 790 800 810
840 850
pF1KB4 EDEVHIC---HNQD-GYSYP--SMVSLEDDVA
:... : :. . :..:: :.:: .::.:
NP_001 EEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
820 830 840
>>NP_001309155 (OMIM: 192977,224050) very low-density li (804 aa)
initn: 2438 init1: 1284 opt: 2915 Z-score: 1987.1 bits: 378.7 E(85289): 6.1e-104
Smith-Waterman score: 3033; 49.0% identity (72.6% similar) in 866 aa overlap (10-858:7-804)
10 20 30 40 50
pF1KB4 MGPWGWKLRWTVALLLA---------AAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAE
:.. :::: :.::. .:: ..::: .:.::. : :::. .
NP_001 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDED
10 20 30 40 50
60 70 80 90 100
pF1KB4 CQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDE--QGCPPKTC
: ::::: ..:.. :: .:: :.. ..:.:. :.:::. ::..:::: . : ::
NP_001 CVDGSDE--KNCVKKTCAESDFVCNN--GQCVPSRWKCDGDPDCEDGSDESPEQCRNITC
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB4 SQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDN
: ::: : .:.::::.:::... :: ::::: .: ::: :::..:.::: :.::.
NP_001 SPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDD
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB4 DPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEE
: :: : ::: ..: :.. . : : :..: ::::::..::::: ::::: :::
NP_001 DADCSDQSDESLEQCGRQPVIH---TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEV
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB4 NCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGEC
:: :::::.:.: ::.::::::::. :: : ::::.: ::. : ::.::::.::::
NP_001 NCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGEC
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB4 ITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQ
: ..::::. .:::::::::.::: :::: :::::::.:.:: ::::: : ::.:. .
NP_001 IDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDR
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB4 RRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEV
. : ::::::.: :::.:.::.:::::.: .:.:.: : .:::::. :.::::...
NP_001 KTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDI
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB4 RKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVI
::. :.:.:: .:. .:::.::::...:.....:.::::. : :...: :. . .:
NP_001 RKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK--VGRHVKMI
420 430 440 450 460
470 480 490 500 510 520
pF1KB4 SRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHG
. .. : ..::::....:::::.. :.::: :.::: :: . .: .:.:::. :
NP_001 D-NVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSG
470 480 490 500 510 520
530 540 550 560 570 580
pF1KB4 FMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSID
:.::.::: ::::.:.:.:: : ::: .:::::::::::...::::.::::: .::.:
NP_001 FVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVD
530 540 550 560 570 580
590 600 610 620 630 640
pF1KB4 VNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSP
.:: .:. .:.. . ::::..:..:::.:.: : :::...::..:::.. :..:: .
NP_001 LNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDA
590 600 610 620 630 640
650 660 670 680 690 700
pF1KB4 EDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMR
.:....:.:.:: : ::::. . ::::.:::::::::: ::::.::.::.:. . .. :
NP_001 QDIIVYHELVQPSGKNWCEED-MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGR
650 660 670 680 690 700
710 720 730 740 750 760
pF1KB4 SCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSH
.: :..:. ::: . ::
NP_001 DCQ---------------RINVT-TAV-----SEVSVP----------------------
710 720
770 780 790 800 810 820
pF1KB4 QALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQ
:... : .::..:::. .: .:.:.::. ::..:.:::::::
NP_001 --------------PKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYL
730 740 750 760
830 840 850
pF1KB4 KTTEDEVHIC---HNQD-GYSYP--SMVSLEDDVA
::::... : :. . :..:: :.:: .::.:
NP_001 KTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
770 780 790 800
858 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 14:54:44 2016 done: Thu Nov 3 14:54:46 2016
Total Scan time: 12.580 Total Display time: 0.340
Function used was FASTA [36.3.4 Apr, 2011]