FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4394, 834 aa 1>>>pF1KB4394 834 - 834 aa - 834 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.9595+/-0.000946; mu= 6.8382+/- 0.058 mean_var=229.8972+/-46.440, 0's: 0 Z-trim(114.3): 20 B-trim: 6 in 1/51 Lambda= 0.084588 statistics sampled from 14835 (14854) to 14835 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.761), E-opt: 0.2 (0.456), width: 16 Scan time: 4.460 The best scores are: opt bits E(32554) CCDS58386.1 PML gene_id:5371|Hs108|chr15 ( 585) 3897 488.6 1.3e-137 CCDS10258.1 PML gene_id:5371|Hs108|chr15 ( 781) 3587 450.9 3.9e-126 CCDS45300.1 PML gene_id:5371|Hs108|chr15 ( 423) 2896 366.4 6e-101 CCDS10256.1 PML gene_id:5371|Hs108|chr15 ( 435) 2896 366.4 6.1e-101 CCDS45299.1 PML gene_id:5371|Hs108|chr15 ( 560) 2896 366.5 7.4e-101 CCDS45298.1 PML gene_id:5371|Hs108|chr15 ( 611) 2896 366.5 7.9e-101 CCDS45297.1 PML gene_id:5371|Hs108|chr15 ( 633) 2896 366.5 8.1e-101 CCDS10257.1 PML gene_id:5371|Hs108|chr15 ( 829) 2896 366.6 9.9e-101 CCDS10255.1 PML gene_id:5371|Hs108|chr15 ( 882) 2896 366.6 1e-100 >>CCDS58386.1 PML gene_id:5371|Hs108|chr15 (585 aa) initn: 3931 init1: 3897 opt: 3897 Z-score: 2584.1 bits: 488.6 E(32554): 1.3e-137 Smith-Waterman score: 3897; 99.8% identity (100.0% similar) in 573 aa overlap (1-573:1-573) 10 20 30 40 50 60 pF1KB4 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLDV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 SNTTTAQKRKCSQTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 SNTTTAQKRKCSQTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 RSPVIGSEVFLPNSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 RSPVIGSEVFLPNSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB4 GPSTLRVLDENLADPQAEDRPLVFFDLKIDNETQKISQLAAVNRESKFRVVIQPEAFFSI ::::::::::::::::::::::::::::::::. CCDS58 GPSTLRVLDENLADPQAEDRPLVFFDLKIDNESGFSWGYPHPFLI 550 560 570 580 610 620 630 640 650 660 pF1KB4 YSKAVSLEVGLQHFLSFLSSMRRPILACYKLWGPGLPNFFRALEDINRLWEFQEAISGFL >>CCDS10258.1 PML gene_id:5371|Hs108|chr15 (781 aa) initn: 3587 init1: 3587 opt: 3587 Z-score: 2378.0 bits: 450.9 E(32554): 3.9e-126 Smith-Waterman score: 3587; 97.9% identity (98.9% similar) in 535 aa overlap (1-535:1-535) 10 20 30 40 50 60 pF1KB4 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLDV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 SNTTTAQKRKCSQTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 SNTTTAQKRKCSQTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 RSPVIGSEVFLPNSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLE :::::::::::::::::::::::::::::::::::::::::: . .. . .:: CCDS10 RSPVIGSEVFLPNSNHVASGAGEAEERVVVISSSEDSDAENSCMEPMETAEPQSSPAHSS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB4 GPSTLRVLDENLADPQAEDRPLVFFDLKIDNETQKISQLAAVNRESKFRVVIQPEAFFSI CCDS10 PAHSSPAHSSPVQSLLRAQGASSLPCGTYHPPAWPPHQPAEQAATPDAEPHSEPPDHQER 550 560 570 580 590 600 >>CCDS45300.1 PML gene_id:5371|Hs108|chr15 (423 aa) initn: 2896 init1: 2896 opt: 2896 Z-score: 1925.9 bits: 366.4 E(32554): 6e-101 Smith-Waterman score: 2896; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KB4 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLRN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 SNTTTAQKRKCSQTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSP CCDS45 ALW >>CCDS10256.1 PML gene_id:5371|Hs108|chr15 (435 aa) initn: 2896 init1: 2896 opt: 2896 Z-score: 1925.7 bits: 366.4 E(32554): 6.1e-101 Smith-Waterman score: 2896; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KB4 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLLP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 SNTTTAQKRKCSQTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSP CCDS10 PPAHALTGPAQSSTH 430 >>CCDS45299.1 PML gene_id:5371|Hs108|chr15 (560 aa) initn: 3458 init1: 2896 opt: 2896 Z-score: 1924.2 bits: 366.5 E(32554): 7.4e-101 Smith-Waterman score: 3367; 91.0% identity (91.2% similar) in 556 aa overlap (1-507:1-556) 10 20 30 40 50 60 pF1KB4 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR 310 320 330 340 350 360 370 380 390 400 410 pF1KB4 QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDL-- :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLPE 370 380 390 400 410 420 420 430 pF1KB4 ----------------------------------------------DVSNTTTAQKRKCS :::::::::::::: CCDS45 EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVPVYAFSIKGPSYGEDVSNTTTAQKRKCS 430 440 450 460 470 480 440 450 460 470 480 490 pF1KB4 QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP 490 500 510 520 530 540 500 510 520 530 540 550 pF1KB4 NSNHVASGAGEA-EERVVVISSSEDSDAENSSSRELDDSSSESSDLQLEGPSTLRVLDEN :::::::::::: .:: CCDS45 NSNHVASGAGEAGRERNALW 550 560 >>CCDS45298.1 PML gene_id:5371|Hs108|chr15 (611 aa) initn: 3565 init1: 2896 opt: 2896 Z-score: 1923.7 bits: 366.5 E(32554): 7.9e-101 Smith-Waterman score: 3479; 88.4% identity (89.9% similar) in 596 aa overlap (1-547:1-596) 10 20 30 40 50 60 pF1KB4 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR 310 320 330 340 350 360 370 380 390 400 410 pF1KB4 QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDL-- :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLPE 370 380 390 400 410 420 420 430 pF1KB4 ----------------------------------------------DVSNTTTAQKRKCS :::::::::::::: CCDS45 EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVPVYAFSIKGPSYGEDVSNTTTAQKRKCS 430 440 450 460 470 480 440 450 460 470 480 490 pF1KB4 QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP 490 500 510 520 530 540 500 510 520 530 540 550 pF1KB4 NSNHVASGAGEAEERVVVISSSEDSDAENS-SSRELDDSSSESSDLQLEGPSTLRVLDEN :::::::::::::::::::::::::::::: :. :.. . : .. .: . .: CCDS45 NSNHVASGAGEAEERVVVISSSEDSDAENSVSGPEVQPRTPASPHFRSQGAQPQQVTLRL 550 560 570 580 590 600 560 570 580 590 600 610 pF1KB4 LADPQAEDRPLVFFDLKIDNETQKISQLAAVNRESKFRVVIQPEAFFSIYSKAVSLEVGL CCDS45 ALRLGNFPVRH 610 >>CCDS45297.1 PML gene_id:5371|Hs108|chr15 (633 aa) initn: 3883 init1: 2896 opt: 2896 Z-score: 1923.5 bits: 366.5 E(32554): 8.1e-101 Smith-Waterman score: 3791; 92.1% identity (92.3% similar) in 621 aa overlap (1-573:1-621) 10 20 30 40 50 60 pF1KB4 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR 310 320 330 340 350 360 370 380 390 400 410 pF1KB4 QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDL-- :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLPE 370 380 390 400 410 420 420 430 pF1KB4 ----------------------------------------------DVSNTTTAQKRKCS :::::::::::::: CCDS45 EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVPVYAFSIKGPSYGEDVSNTTTAQKRKCS 430 440 450 460 470 480 440 450 460 470 480 490 pF1KB4 QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP 490 500 510 520 530 540 500 510 520 530 540 550 pF1KB4 NSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLEGPSTLRVLDENL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 NSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLEGPSTLRVLDENL 550 560 570 580 590 600 560 570 580 590 600 610 pF1KB4 ADPQAEDRPLVFFDLKIDNETQKISQLAAVNRESKFRVVIQPEAFFSIYSKAVSLEVGLQ ::::::::::::::::::::. CCDS45 ADPQAEDRPLVFFDLKIDNESGFSWGYPHPFLI 610 620 630 >>CCDS10257.1 PML gene_id:5371|Hs108|chr15 (829 aa) initn: 3573 init1: 2896 opt: 2896 Z-score: 1921.9 bits: 366.6 E(32554): 9.9e-101 Smith-Waterman score: 3481; 89.9% identity (90.7% similar) in 583 aa overlap (1-535:1-583) 10 20 30 40 50 60 pF1KB4 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR 310 320 330 340 350 360 370 380 390 400 410 pF1KB4 QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDL-- :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLPE 370 380 390 400 410 420 420 430 pF1KB4 ----------------------------------------------DVSNTTTAQKRKCS :::::::::::::: CCDS10 EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVPVYAFSIKGPSYGEDVSNTTTAQKRKCS 430 440 450 460 470 480 440 450 460 470 480 490 pF1KB4 QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP 490 500 510 520 530 540 500 510 520 530 540 550 pF1KB4 NSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLEGPSTLRVLDENL :::::::::::::::::::::::::::::: . .. . .:: CCDS10 NSNHVASGAGEAEERVVVISSSEDSDAENSCMEPMETAEPQSSPAHSSPAHSSPAHSSPV 550 560 570 580 590 600 560 570 580 590 600 610 pF1KB4 ADPQAEDRPLVFFDLKIDNETQKISQLAAVNRESKFRVVIQPEAFFSIYSKAVSLEVGLQ CCDS10 QSLLRAQGASSLPCGTYHPPAWPPHQPAEQAATPDAEPHSEPPDHQERPAVHRGIRYLLY 610 620 630 640 650 660 >>CCDS10255.1 PML gene_id:5371|Hs108|chr15 (882 aa) initn: 5575 init1: 2896 opt: 2896 Z-score: 1921.5 bits: 366.6 E(32554): 1e-100 Smith-Waterman score: 5383; 94.5% identity (94.5% similar) in 866 aa overlap (1-818:1-866) 10 20 30 40 50 60 pF1KB4 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR 310 320 330 340 350 360 370 380 390 400 410 pF1KB4 QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDL-- :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLPE 370 380 390 400 410 420 420 430 pF1KB4 ----------------------------------------------DVSNTTTAQKRKCS :::::::::::::: CCDS10 EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVPVYAFSIKGPSYGEDVSNTTTAQKRKCS 430 440 450 460 470 480 440 450 460 470 480 490 pF1KB4 QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP 490 500 510 520 530 540 500 510 520 530 540 550 pF1KB4 NSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLEGPSTLRVLDENL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 NSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLEGPSTLRVLDENL 550 560 570 580 590 600 560 570 580 590 600 610 pF1KB4 ADPQAEDRPLVFFDLKIDNETQKISQLAAVNRESKFRVVIQPEAFFSIYSKAVSLEVGLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 ADPQAEDRPLVFFDLKIDNETQKISQLAAVNRESKFRVVIQPEAFFSIYSKAVSLEVGLQ 610 620 630 640 650 660 620 630 640 650 660 670 pF1KB4 HFLSFLSSMRRPILACYKLWGPGLPNFFRALEDINRLWEFQEAISGFLAALPLIRERVPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 HFLSFLSSMRRPILACYKLWGPGLPNFFRALEDINRLWEFQEAISGFLAALPLIRERVPG 670 680 690 700 710 720 680 690 700 710 720 730 pF1KB4 ASSFKLKNLAQTYLARNMSERSAMAAVLAMRDLCRLLEVSPGPQLAQHVYPFSSLQCFAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 ASSFKLKNLAQTYLARNMSERSAMAAVLAMRDLCRLLEVSPGPQLAQHVYPFSSLQCFAS 730 740 750 760 770 780 740 750 760 770 780 790 pF1KB4 LQPLVQAAVLPRAEARLLALHNVSFMELLSAHRRDRQGGLKKYSRYLSLQTTTLPPAQPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 LQPLVQAAVLPRAEARLLALHNVSFMELLSAHRRDRQGGLKKYSRYLSLQTTTLPPAQPA 790 800 810 820 830 840 800 810 820 830 pF1KB4 FNLQALGTYFEGLLEGPALARAEGVSTPLAGRGLAERASQQS :::::::::::::::::::::::::: CCDS10 FNLQALGTYFEGLLEGPALARAEGVSTPLAGRGLAERASQQS 850 860 870 880 834 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 14:56:38 2016 done: Thu Nov 3 14:56:39 2016 Total Scan time: 4.460 Total Display time: 0.140 Function used was FASTA [36.3.4 Apr, 2011]