FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4411, 186 aa 1>>>pF1KB4411 186 - 186 aa - 186 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.5656+/-0.000386; mu= 17.6297+/- 0.024 mean_var=80.2420+/-16.252, 0's: 0 Z-trim(114.7): 367 B-trim: 632 in 1/53 Lambda= 0.143177 statistics sampled from 24206 (24653) to 24206 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.689), E-opt: 0.2 (0.289), width: 16 Scan time: 5.740 The best scores are: opt bits E(85289) XP_006724169 (OMIM: 615870,615996) PREDICTED: intr ( 186) 1232 263.6 1.3e-70 NP_001171172 (OMIM: 615870,615996) intraflagellar ( 186) 1232 263.6 1.3e-70 NP_006851 (OMIM: 615870,615996) intraflagellar tra ( 185) 1212 259.5 2.3e-69 XP_016884029 (OMIM: 615870,615996) PREDICTED: intr ( 145) 970 209.4 2.2e-54 NP_006852 (OMIM: 604199) ras-related protein Rab-3 ( 201) 322 75.7 5.3e-14 NP_055303 (OMIM: 605693) ras-related protein Rab-3 ( 203) 321 75.5 6.1e-14 NP_001272988 (OMIM: 605693) ras-related protein Ra ( 203) 321 75.5 6.1e-14 NP_001272990 (OMIM: 605693) ras-related protein Ra ( 203) 321 75.5 6.1e-14 NP_001272989 (OMIM: 605693) ras-related protein Ra ( 203) 321 75.5 6.1e-14 NP_004152 (OMIM: 179508) ras-related protein Rab-1 ( 205) 321 75.5 6.1e-14 NP_112243 (OMIM: 612565) ras-related protein Rab-1 ( 201) 315 74.2 1.4e-13 NP_002861 (OMIM: 602672) ras-related protein Rab-1 ( 203) 311 73.4 2.6e-13 NP_002856 (OMIM: 179509) ras-related protein Rab-2 ( 212) 311 73.4 2.6e-13 NP_116235 (OMIM: 607466) ras-related protein Rab-2 ( 216) 305 72.2 6.3e-13 NP_005361 (OMIM: 165040) ras-related protein Rab-8 ( 207) 302 71.6 9.4e-13 NP_057215 (OMIM: 612672) ras-related protein Rab-1 ( 200) 301 71.3 1.1e-12 NP_057614 (OMIM: 613532) ras-related protein Rab-8 ( 207) 301 71.4 1.1e-12 NP_004153 (OMIM: 179512) ras-related protein Rab-5 ( 215) 301 71.4 1.1e-12 NP_004785 (OMIM: 300333) ras-related protein Rab-3 ( 237) 299 71.0 1.6e-12 XP_011526322 (OMIM: 165040) PREDICTED: ras-related ( 215) 296 70.3 2.3e-12 NP_001006639 (OMIM: 609956) ras-related protein Ra ( 223) 296 70.4 2.3e-12 NP_001265595 (OMIM: 201000,606144) ras-related pro ( 237) 294 70.0 3.2e-12 NP_001265596 (OMIM: 201000,606144) ras-related pro ( 237) 294 70.0 3.2e-12 NP_899050 (OMIM: 201000,606144) ras-related protei ( 237) 294 70.0 3.2e-12 NP_057361 (OMIM: 201000,606144) ras-related protei ( 237) 294 70.0 3.2e-12 NP_001265597 (OMIM: 201000,606144) ras-related pro ( 237) 294 70.0 3.2e-12 NP_055168 (OMIM: 605455) ras-related protein Rab-2 ( 256) 294 70.0 3.4e-12 NP_001317400 (OMIM: 609956) ras-related protein Ra ( 196) 292 69.5 3.8e-12 NP_001157461 (OMIM: 609956) ras-related protein Ra ( 228) 292 69.5 4.2e-12 NP_001294982 (OMIM: 605455) ras-related protein Ra ( 190) 286 68.2 8.8e-12 XP_011523393 (OMIM: 604037) PREDICTED: ras-related ( 216) 285 68.1 1.1e-11 NP_958842 (OMIM: 604037) ras-related protein Rab-5 ( 216) 285 68.1 1.1e-11 XP_011523392 (OMIM: 604037) PREDICTED: ras-related ( 216) 285 68.1 1.1e-11 NP_004574 (OMIM: 604037) ras-related protein Rab-5 ( 216) 285 68.1 1.1e-11 NP_001238968 (OMIM: 604037) ras-related protein Ra ( 249) 285 68.1 1.2e-11 NP_783865 (OMIM: 609956) ras-related protein Rab-3 ( 216) 283 67.7 1.5e-11 NP_057661 (OMIM: 615852) ras-related protein Rab-6 ( 208) 282 67.4 1.7e-11 NP_004654 (OMIM: 605570) ras-related protein Rab-1 ( 216) 282 67.5 1.7e-11 NP_942599 (OMIM: 179513) ras-related protein Rab-6 ( 208) 280 67.0 2.2e-11 NP_741995 (OMIM: 300774) ras-related protein Rab-3 ( 213) 280 67.0 2.2e-11 XP_005269109 (OMIM: 179514) PREDICTED: ras-related ( 215) 279 66.8 2.6e-11 XP_005269108 (OMIM: 179514) PREDICTED: ras-related ( 215) 279 66.8 2.6e-11 NP_002859 (OMIM: 179514) ras-related protein Rab-5 ( 215) 279 66.8 2.6e-11 NP_001238965 (OMIM: 179514) ras-related protein Ra ( 215) 279 66.8 2.6e-11 XP_011511195 (OMIM: 615852) PREDICTED: ras-related ( 195) 273 65.5 5.7e-11 NP_002860 (OMIM: 179513) ras-related protein Rab-6 ( 208) 273 65.6 6e-11 NP_057406 (OMIM: 612673) ras-related protein Rab-1 ( 215) 272 65.4 7.1e-11 XP_011526466 (OMIM: 179490) PREDICTED: ras-related ( 220) 271 65.2 8.3e-11 NP_002857 (OMIM: 179490) ras-related protein Rab-3 ( 220) 271 65.2 8.3e-11 NP_006859 (OMIM: 605694) ras-related protein Rab-3 ( 195) 269 64.7 1e-10 >>XP_006724169 (OMIM: 615870,615996) PREDICTED: intrafla (186 aa) initn: 1232 init1: 1232 opt: 1232 Z-score: 1388.7 bits: 263.6 E(85289): 1.3e-70 Smith-Waterman score: 1232; 100.0% identity (100.0% similar) in 186 aa overlap (1-186:1-186) 10 20 30 40 50 60 pF1KB4 MVKLAAKCILAGDPAVGKTALAQIFRSDGAHFQKSYTLTTGMDLVVKTVPVPDTGDSVEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MVKLAAKCILAGDPAVGKTALAQIFRSDGAHFQKSYTLTTGMDLVVKTVPVPDTGDSVEL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 FIFDSAGKELFSEMLDKLWESPNVLCLVYDVTNEESFNNCSKWLEKARSQAPGISLPGVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FIFDSAGKELFSEMLDKLWESPNVLCLVYDVTNEESFNNCSKWLEKARSQAPGISLPGVL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 VGNKTDLAGRRAVDSAEARAWALGQGLECFETSVKEMENFEAPFHCLAKQFHQLYREKVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VGNKTDLAGRRAVDSAEARAWALGQGLECFETSVKEMENFEAPFHCLAKQFHQLYREKVE 130 140 150 160 170 180 pF1KB4 VFRALA :::::: XP_006 VFRALA >>NP_001171172 (OMIM: 615870,615996) intraflagellar tran (186 aa) initn: 1232 init1: 1232 opt: 1232 Z-score: 1388.7 bits: 263.6 E(85289): 1.3e-70 Smith-Waterman score: 1232; 100.0% identity (100.0% similar) in 186 aa overlap (1-186:1-186) 10 20 30 40 50 60 pF1KB4 MVKLAAKCILAGDPAVGKTALAQIFRSDGAHFQKSYTLTTGMDLVVKTVPVPDTGDSVEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVKLAAKCILAGDPAVGKTALAQIFRSDGAHFQKSYTLTTGMDLVVKTVPVPDTGDSVEL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 FIFDSAGKELFSEMLDKLWESPNVLCLVYDVTNEESFNNCSKWLEKARSQAPGISLPGVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FIFDSAGKELFSEMLDKLWESPNVLCLVYDVTNEESFNNCSKWLEKARSQAPGISLPGVL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 VGNKTDLAGRRAVDSAEARAWALGQGLECFETSVKEMENFEAPFHCLAKQFHQLYREKVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGNKTDLAGRRAVDSAEARAWALGQGLECFETSVKEMENFEAPFHCLAKQFHQLYREKVE 130 140 150 160 170 180 pF1KB4 VFRALA :::::: NP_001 VFRALA >>NP_006851 (OMIM: 615870,615996) intraflagellar transpo (185 aa) initn: 1210 init1: 1157 opt: 1212 Z-score: 1366.4 bits: 259.5 E(85289): 2.3e-69 Smith-Waterman score: 1212; 99.5% identity (99.5% similar) in 186 aa overlap (1-186:1-185) 10 20 30 40 50 60 pF1KB4 MVKLAAKCILAGDPAVGKTALAQIFRSDGAHFQKSYTLTTGMDLVVKTVPVPDTGDSVEL ::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MVKLAAKCILA-DPAVGKTALAQIFRSDGAHFQKSYTLTTGMDLVVKTVPVPDTGDSVEL 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 FIFDSAGKELFSEMLDKLWESPNVLCLVYDVTNEESFNNCSKWLEKARSQAPGISLPGVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 FIFDSAGKELFSEMLDKLWESPNVLCLVYDVTNEESFNNCSKWLEKARSQAPGISLPGVL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB4 VGNKTDLAGRRAVDSAEARAWALGQGLECFETSVKEMENFEAPFHCLAKQFHQLYREKVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VGNKTDLAGRRAVDSAEARAWALGQGLECFETSVKEMENFEAPFHCLAKQFHQLYREKVE 120 130 140 150 160 170 pF1KB4 VFRALA :::::: NP_006 VFRALA 180 >>XP_016884029 (OMIM: 615870,615996) PREDICTED: intrafla (145 aa) initn: 970 init1: 970 opt: 970 Z-score: 1097.5 bits: 209.4 E(85289): 2.2e-54 Smith-Waterman score: 970; 100.0% identity (100.0% similar) in 145 aa overlap (42-186:1-145) 20 30 40 50 60 70 pF1KB4 GDPAVGKTALAQIFRSDGAHFQKSYTLTTGMDLVVKTVPVPDTGDSVELFIFDSAGKELF :::::::::::::::::::::::::::::: XP_016 MDLVVKTVPVPDTGDSVELFIFDSAGKELF 10 20 30 80 90 100 110 120 130 pF1KB4 SEMLDKLWESPNVLCLVYDVTNEESFNNCSKWLEKARSQAPGISLPGVLVGNKTDLAGRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEMLDKLWESPNVLCLVYDVTNEESFNNCSKWLEKARSQAPGISLPGVLVGNKTDLAGRR 40 50 60 70 80 90 140 150 160 170 180 pF1KB4 AVDSAEARAWALGQGLECFETSVKEMENFEAPFHCLAKQFHQLYREKVEVFRALA ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVDSAEARAWALGQGLECFETSVKEMENFEAPFHCLAKQFHQLYREKVEVFRALA 100 110 120 130 140 >>NP_006852 (OMIM: 604199) ras-related protein Rab-35 is (201 aa) initn: 216 init1: 104 opt: 322 Z-score: 372.4 bits: 75.7 E(85289): 5.3e-14 Smith-Waterman score: 322; 35.0% identity (66.9% similar) in 163 aa overlap (7-169:10-166) 10 20 30 40 50 pF1KB4 MVKLAAKCILAGDPAVGKTALAQIFRSDGAHFQKSYTLTTGMDLVVKTVPVPDTGDS : .. :: .:::..: ..: :. :: : :.:. ..:: . .:.. NP_006 MARDYDHLFKLLIIGDSGVGKSSL--LLRFADNTFSGSYITTIGVDFKIRTVEI--NGEK 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 VELFIFDSAGKELFSEMLDKLWESPNVLCLVYDVTNEESFNNCSKWLEKARSQAPGISLP :.: :.:.::.: : . . ... . . .:::::. ::: : ..::.. .. . NP_006 VKLQIWDTAGQERFRTITSTYYRGTHGVIVVYDVTSAESFVNVKRWLHEINQNCDDVC-- 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 GVLVGNKTDLAGRRAVDSAEARAWALGQGLECFETSVKEMENFEAPFHCLAKQFHQLYRE .:::::.: :..:.. .: .: .:.. ::::.:: : : :.:... NP_006 RILVGNKNDDPERKVVETEDAYKFAGQMGIQLFETSAKENVNVEEMFNCITELVLRAKKD 120 130 140 150 160 170 180 pF1KB4 KVEVFRALA NP_006 NLAKQQQQQQNDVVKLTKNSKRKKRCC 180 190 200 >>NP_055303 (OMIM: 605693) ras-related protein Rab-30 [H (203 aa) initn: 238 init1: 121 opt: 321 Z-score: 371.3 bits: 75.5 E(85289): 6.1e-14 Smith-Waterman score: 321; 37.7% identity (68.0% similar) in 175 aa overlap (7-181:11-180) 10 20 30 40 50 pF1KB4 MVKLAAKCILAGDPAVGKTALAQIFRSDGAHFQKSYTLTTGMDLVVKTVPVPDTGD : .: :. .:::: :.. : ..: : . : :.:...::: . .:. NP_055 MSMEDYDFLFKIVLIGNAGVGKTCLVRRF-TQGL-FPPGQGATIGVDFMIKTVEI--NGE 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 SVELFIFDSAGKELFSEMLDKLWESPNVLCLVYDVTNEESFNNCSKWLEKARSQAPGISL .:.: :.:.::.: : . .. ..: :.: :.::.: :::: .::.. .. : . .. NP_055 KVKLQIWDTAGQERFRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYASN-KV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 PGVLVGNKTDLAGRRAVDSAEARAWALGQGLECFETSVKEMENFEAPFHCLAKQFHQLYR :::::: ::: :: :.. .:. .. .: . .:::.:: .: : : :: .. . : NP_055 ITVLVGNKIDLAERREVSQQRAEEFSEAQDMYYLETSAKESDNVEKLFLDLACRLISEAR 120 130 140 150 160 170 180 pF1KB4 EKVEVFRALA ... : NP_055 QNTLVNNVSSPLPGEGKSISYLTCCNFN 180 190 200 >>NP_001272988 (OMIM: 605693) ras-related protein Rab-30 (203 aa) initn: 238 init1: 121 opt: 321 Z-score: 371.3 bits: 75.5 E(85289): 6.1e-14 Smith-Waterman score: 321; 37.7% identity (68.0% similar) in 175 aa overlap (7-181:11-180) 10 20 30 40 50 pF1KB4 MVKLAAKCILAGDPAVGKTALAQIFRSDGAHFQKSYTLTTGMDLVVKTVPVPDTGD : .: :. .:::: :.. : ..: : . : :.:...::: . .:. NP_001 MSMEDYDFLFKIVLIGNAGVGKTCLVRRF-TQGL-FPPGQGATIGVDFMIKTVEI--NGE 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 SVELFIFDSAGKELFSEMLDKLWESPNVLCLVYDVTNEESFNNCSKWLEKARSQAPGISL .:.: :.:.::.: : . .. ..: :.: :.::.: :::: .::.. .. : . .. NP_001 KVKLQIWDTAGQERFRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYASN-KV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 PGVLVGNKTDLAGRRAVDSAEARAWALGQGLECFETSVKEMENFEAPFHCLAKQFHQLYR :::::: ::: :: :.. .:. .. .: . .:::.:: .: : : :: .. . : NP_001 ITVLVGNKIDLAERREVSQQRAEEFSEAQDMYYLETSAKESDNVEKLFLDLACRLISEAR 120 130 140 150 160 170 180 pF1KB4 EKVEVFRALA ... : NP_001 QNTLVNNVSSPLPGEGKSISYLTCCNFN 180 190 200 >>NP_001272990 (OMIM: 605693) ras-related protein Rab-30 (203 aa) initn: 238 init1: 121 opt: 321 Z-score: 371.3 bits: 75.5 E(85289): 6.1e-14 Smith-Waterman score: 321; 37.7% identity (68.0% similar) in 175 aa overlap (7-181:11-180) 10 20 30 40 50 pF1KB4 MVKLAAKCILAGDPAVGKTALAQIFRSDGAHFQKSYTLTTGMDLVVKTVPVPDTGD : .: :. .:::: :.. : ..: : . : :.:...::: . .:. NP_001 MSMEDYDFLFKIVLIGNAGVGKTCLVRRF-TQGL-FPPGQGATIGVDFMIKTVEI--NGE 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 SVELFIFDSAGKELFSEMLDKLWESPNVLCLVYDVTNEESFNNCSKWLEKARSQAPGISL .:.: :.:.::.: : . .. ..: :.: :.::.: :::: .::.. .. : . .. NP_001 KVKLQIWDTAGQERFRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYASN-KV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 PGVLVGNKTDLAGRRAVDSAEARAWALGQGLECFETSVKEMENFEAPFHCLAKQFHQLYR :::::: ::: :: :.. .:. .. .: . .:::.:: .: : : :: .. . : NP_001 ITVLVGNKIDLAERREVSQQRAEEFSEAQDMYYLETSAKESDNVEKLFLDLACRLISEAR 120 130 140 150 160 170 180 pF1KB4 EKVEVFRALA ... : NP_001 QNTLVNNVSSPLPGEGKSISYLTCCNFN 180 190 200 >>NP_001272989 (OMIM: 605693) ras-related protein Rab-30 (203 aa) initn: 238 init1: 121 opt: 321 Z-score: 371.3 bits: 75.5 E(85289): 6.1e-14 Smith-Waterman score: 321; 37.7% identity (68.0% similar) in 175 aa overlap (7-181:11-180) 10 20 30 40 50 pF1KB4 MVKLAAKCILAGDPAVGKTALAQIFRSDGAHFQKSYTLTTGMDLVVKTVPVPDTGD : .: :. .:::: :.. : ..: : . : :.:...::: . .:. NP_001 MSMEDYDFLFKIVLIGNAGVGKTCLVRRF-TQGL-FPPGQGATIGVDFMIKTVEI--NGE 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 SVELFIFDSAGKELFSEMLDKLWESPNVLCLVYDVTNEESFNNCSKWLEKARSQAPGISL .:.: :.:.::.: : . .. ..: :.: :.::.: :::: .::.. .. : . .. NP_001 KVKLQIWDTAGQERFRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYASN-KV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 PGVLVGNKTDLAGRRAVDSAEARAWALGQGLECFETSVKEMENFEAPFHCLAKQFHQLYR :::::: ::: :: :.. .:. .. .: . .:::.:: .: : : :: .. . : NP_001 ITVLVGNKIDLAERREVSQQRAEEFSEAQDMYYLETSAKESDNVEKLFLDLACRLISEAR 120 130 140 150 160 170 180 pF1KB4 EKVEVFRALA ... : NP_001 QNTLVNNVSSPLPGEGKSISYLTCCNFN 180 190 200 >>NP_004152 (OMIM: 179508) ras-related protein Rab-1A is (205 aa) initn: 264 init1: 119 opt: 321 Z-score: 371.2 bits: 75.5 E(85289): 6.1e-14 Smith-Waterman score: 321; 34.1% identity (66.5% similar) in 167 aa overlap (7-173:13-174) 10 20 30 40 50 pF1KB4 MVKLAAKCILAGDPAVGKTALAQIFRSDGAHFQKSYTLTTGMDLVVKTVPVPDT : .: :: .:::. : : .: . .:: : :.:. ..:. . NP_004 MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDT--YTESYISTIGVDFKIRTIELD-- 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 GDSVELFIFDSAGKELFSEMLDKLWESPNVLCLVYDVTNEESFNNCSKWLEKARSQAPGI : ...: :.:.::.: : . .. ... . . .:::::..::::: ..::.. : . NP_004 GKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYA-SE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 SLPGVLVGNKTDLAGRRAVDSAEARAWALGQGLECFETSVKEMENFEAPFHCLAKQFHQL .. .::::: ::. ...:: . :. .: . :. .:::.:. : : : .: .... NP_004 NVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKR 120 130 140 150 160 170 180 pF1KB4 YREKVEVFRALA NP_004 MGPGATAGGAEKSNVKIQSTPVKQSGGGCC 180 190 200 186 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 03:00:15 2016 done: Fri Nov 4 03:00:16 2016 Total Scan time: 5.740 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]