Result of FASTA (ccds) for pF1KB4489
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB4489, 467 aa
  1>>>pF1KB4489 467 - 467 aa - 467 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.8538+/-0.000974; mu= -2.5690+/- 0.059
 mean_var=222.2871+/-45.233, 0's: 0 Z-trim(113.1): 19  B-trim: 2 in 1/51
 Lambda= 0.086024
 statistics sampled from 13787 (13801) to 13787 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.763), E-opt: 0.2 (0.424), width:  16
 Scan time:  2.870

The best scores are:                                      opt bits E(32554)
CCDS45032.1 SMAD9 gene_id:4093|Hs108|chr13         ( 467) 3298 421.9  7e-118
CCDS3765.1 SMAD1 gene_id:4086|Hs108|chr4           ( 465) 2642 340.5 2.2e-93
CCDS75308.1 SMAD5 gene_id:4090|Hs108|chr5          ( 465) 2584 333.3 3.3e-91
CCDS9360.1 SMAD9 gene_id:4093|Hs108|chr13          ( 430) 1599 211.0 1.9e-54
CCDS11934.1 SMAD2 gene_id:4087|Hs108|chr18         ( 467) 1320 176.4 5.5e-44
CCDS53950.1 SMAD3 gene_id:4088|Hs108|chr15         ( 320) 1153 155.6 6.9e-38
CCDS45288.1 SMAD3 gene_id:4088|Hs108|chr15         ( 381) 1153 155.7   8e-38
CCDS10222.1 SMAD3 gene_id:4088|Hs108|chr15         ( 425) 1153 155.7 8.8e-38
CCDS53951.1 SMAD3 gene_id:4088|Hs108|chr15         ( 230) 1113 150.6 1.6e-36
CCDS11950.1 SMAD4 gene_id:4089|Hs108|chr18         ( 552)  493 73.8   5e-13


>>CCDS45032.1 SMAD9 gene_id:4093|Hs108|chr13              (467 aa)
 initn: 3298 init1: 3298 opt: 3298  Z-score: 2229.8  bits: 421.9 E(32554): 7e-118
Smith-Waterman score: 3298; 100.0% identity (100.0% similar) in 467 aa overlap (1-467:1-467)

               10        20        30        40        50        60
pF1KB4 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 FQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 FQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQ
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 SGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 SGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 FTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 FTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 NCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 NCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVK
              370       380       390       400       410       420

              430       440       450       460       
pF1KB4 GWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
       :::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 GWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
              430       440       450       460       

>>CCDS3765.1 SMAD1 gene_id:4086|Hs108|chr4                (465 aa)
 initn: 2637 init1: 1354 opt: 2642  Z-score: 1789.9  bits: 340.5 E(32554): 2.2e-93
Smith-Waterman score: 2642; 81.5% identity (90.8% similar) in 465 aa overlap (7-467:3-465)

               10        20        30        40        50        60
pF1KB4 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS
             ..:::::::::::::::::::::::::::::::.::::::::::::.:::.:::
CCDS37     MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALS
                   10        20        30        40        50      

               70        80        90       100       110       120
pF1KB4 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
       ::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 CPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
         60        70        80        90       100       110      

              130       140       150       160       170       180
pF1KB4 QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS
       :::::::::::.:::.::::::::::::::::: ::::.::. . ..:: :: :::.:::
CCDS37 QKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLG-QNEPHMPLNATFPDS
        120       130       140       150       160        170     

              190       200         210       220       230        
pF1KB4 FQQPPCSALPPSPSHAFSQSPCTAS--YPHSPGSPSEPESPYQHSVDTPPLPYHATEASE
       ::::    .: ::. .. .:: ..:  ::::: : :.: ::.:  .::::  :   :   
CCDS37 FQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTS-SDPGSPFQMPADTPPPAYLPPEDPM
         180       190       200        210       220       230    

      240        250        260       270       280       290      
pF1KB4 TQSG-QPVDATADRHVVLS-IPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSV
       ::.: ::.:..     . : :  :: . : ::::.::::..::::::::::.:.::: ::
CCDS37 TQDGSQPMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSV
          240       250       260       270       280       290    

        300       310       320       330       340       350      
pF1KB4 LIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIF
       :.:::::::::.:::::::::::::::::::::::::::::::::::::::::.::::::
CCDS37 LVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIF
          300       310       320       330       340       350    

        360       370       380       390       400       410      
pF1KB4 VQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRM
       ::::::::.:::::.::::::::::::.:::: :::::::::.::::.::::::::::::
CCDS37 VQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRM
          360       370       380       390       400       410    

        420       430       440       450       460       
pF1KB4 SFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
       :::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 SFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
          420       430       440       450       460     

>>CCDS75308.1 SMAD5 gene_id:4090|Hs108|chr5               (465 aa)
 initn: 2563 init1: 1333 opt: 2584  Z-score: 1751.0  bits: 333.3 E(32554): 3.3e-91
Smith-Waterman score: 2584; 78.8% identity (91.0% similar) in 466 aa overlap (5-467:2-465)

               10        20        30        40        50        60
pF1KB4 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS
           : ..:::::::::::::::::::::::::::::::.::::::::::::.:::.:::
CCDS75    MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALS
                  10        20        30        40        50       

               70        80        90       100       110       120
pF1KB4 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
        :::::::::::::::::::::::::::::::::::::::::::::::::. ::::::::
CCDS75 SPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSK
        60        70        80        90       100       110       

              130       140       150       160       170       180
pF1KB4 QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS
       :::::::::::.:::.:::::::::::.:.::: :::..::. : :.:: ::.:::.:::
CCDS75 QKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLS-HNEPHMPQNATFPDS
       120       130       140       150       160        170      

              190       200       210       220       230       240
pF1KB4 FQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQ
       :.::  . .: ::.  .  :: ...::.::.: : : ::.:  .::::  :   . .  :
CCDS75 FHQPNNTPFPLSPNSPYPPSPASSTYPNSPAS-SGPGSPFQLPADTPPPAYMPPDDQMGQ
        180       190       200        210       220       230     

               250         260       270       280       290       
pF1KB4 -SGQPVDATADR--HVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVL
        ..::.:.. .   ... :: . : .:: ::::.::::..::::::::::.:.::: :::
CCDS75 DNSQPMDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVL
         240       250       260       270       280       290     

       300       310       320       330       340       350       
pF1KB4 IDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFV
       .:::::::::..::::::::::::::::::::::::::::::::::::::::.:::::::
CCDS75 VDGFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFV
         300       310       320       330       340       350     

       360       370       380       390       400       410       
pF1KB4 QSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMS
       ::::::..:::::.:::::::.::::.:::: :::::::::.::::.:::::::::::::
CCDS75 QSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMS
         360       370       380       390       400       410     

       420       430       440       450       460       
pF1KB4 FVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
       :::::::::::::::::::::::::::::::::::::::::: :::::::
CCDS75 FVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS
         420       430       440       450       460     

>>CCDS9360.1 SMAD9 gene_id:4093|Hs108|chr13               (430 aa)
 initn: 1593 init1: 1593 opt: 1599  Z-score: 1090.8  bits: 211.0 E(32554): 1.9e-54
Smith-Waterman score: 2966; 92.1% identity (92.1% similar) in 467 aa overlap (1-467:1-430)

               10        20        30        40        50        60
pF1KB4 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS93 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS93 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS93 QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 FQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQ
       :::::::::::::::::::::::::::::::::::::::::::                 
CCDS93 FQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHS-----------------
              190       200       210       220                    

              250       260       270       280       290       300
pF1KB4 SGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDG
                           ::::::::::::::::::::::::::::::::::::::::
CCDS93 --------------------DFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDG
                               230       240       250       260   

              310       320       330       340       350       360
pF1KB4 FTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS93 FTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSR
           270       280       290       300       310       320   

              370       380       390       400       410       420
pF1KB4 NCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS93 NCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVK
           330       340       350       360       370       380   

              430       440       450       460       
pF1KB4 GWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
       :::::::::::::::::::::::::::::::::::::::::::::::
CCDS93 GWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
           390       400       410       420       430

>>CCDS11934.1 SMAD2 gene_id:4087|Hs108|chr18              (467 aa)
 initn: 1759 init1: 894 opt: 1320  Z-score: 903.1  bits: 176.4 E(32554): 5.5e-44
Smith-Waterman score: 1754; 56.7% identity (72.0% similar) in 504 aa overlap (7-467:1-467)

               10        20                     30        40       
pF1KB4 MHSTTPISSLFSFTSPAVKRLLGWK-------------QGDEEEKWAEKAVDSLVKKLKK
             .::.. :: :.::::::::             :. .:::: :::: ::::::::
CCDS11       MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKK
                     10        20        30        40        50    

        50        60        70                                     
pF1KB4 KKGAMDELERALSCPGQPSKCVTIP------------------------------RSLDG
         : .::::.:..  .  .::::::                              :::::
CCDS11 T-GRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDG
            60        70        80        90       100       110   

        80        90       100       110       120       130       
pF1KB4 RLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETP
       :::::::::::::::::.::::::.:::::: .: ::. :. :. :::.:::::.:::::
CCDS11 RLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETP
           120       130       140       150       160       170   

       140       150       160       170       180       190       
pF1KB4 VLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQPPCSALPPSPSHAF
       ::::::::::.:   .:  :  .     ::   .:.:...: ... :  . .: .:    
CCDS11 VLPPVLVPRHTEILTELPPLDDYT----HS---IPENTNFPAGIE-PQSNYIPETP----
           180       190              200       210        220     

       200       210       220       230       240       250       
pF1KB4 SQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQSGQPVDATADRHVVLSI
          :   .:    :  :. .   ..:.::   :   .: : : . .::.     : .   
CCDS11 --PP---GYISEDGETSDQQ--LNQSMDTGS-P---AELSPT-TLSPVN-----HSL---
                  230         240           250             260    

       260       270       280       290       300       310       
pF1KB4 PNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLS
          :..:: : ::  :::.::::::.::::::.::. :. .::::::::.. ::::::::
CCDS11 ---DLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSE-RFCLGLLS
                270       280       290       300        310       

       320       330       340       350       360       370       
pF1KB4 NVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIP
       :::::.:.: ::::::.::.:::.::::.:::.:::.::::: ::: ..:.:::::::::
CCDS11 NVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIP
       320       330       340       350       360       370       

       380       390       400       410       420       430       
pF1KB4 SGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCW
        ::.::.:::: :: ::::::..:::.::.::.::::::::::::::::.:: :::::::
CCDS11 PGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCW
       380       390       400       410       420       430       

       440       450       460       
pF1KB4 IEIHLHGPLQWLDKVLTQMGSPHNPISSVS
       ::.::.::::::::::::::::    ::.:
CCDS11 IELHLNGPLQWLDKVLTQMGSPSVRCSSMS
       440       450       460       

>>CCDS53950.1 SMAD3 gene_id:4088|Hs108|chr15              (320 aa)
 initn: 1115 init1: 898 opt: 1153  Z-score: 793.6  bits: 155.6 E(32554): 6.9e-38
Smith-Waterman score: 1337; 57.9% identity (75.8% similar) in 359 aa overlap (110-467:1-320)

      80        90       100       110       120       130         
pF1KB4 QVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETPVL
                                     .: ::: :. :. :::.:::::.:::::::
CCDS53                               MELCEFAFNMKKDEVCVNPYHYQRVETPVL
                                             10        20        30

     140       150       160       170       180       190         
pF1KB4 PPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQPPCSALPPSPSHAFSQ
       ::::::::.:   ..  :  .     ::   .:.:...: ...  : : .: .:      
CCDS53 PPVLVPRHTEIPAEFPPLDDYS----HS---IPENTNFPAGIE--PQSNIPETP------
               40        50               60          70           

     200       210       220       230        240       250        
pF1KB4 SPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEA-SETQSGQPVDATADRHVVLSIP
        :        ::  ::     .:...      :. .: : . : .:.. . .        
CCDS53 -P--------PGYLSEDGETSDHQMN------HSMDAGSPNLSPNPMSPAHN--------
                   80        90             100       110          

      260       270       280       290       300       310        
pF1KB4 NGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSN
       : :..:: : ::  :::..:::::.::::::.::. :. .::::::::.. :::::::::
CCDS53 NLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSE-RFCLGLLSN
            120       130       140       150       160        170 

      320       330       340       350       360       370        
pF1KB4 VNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPS
       ::::...: ::::::.::.:::.::::.:::.:::.::::: ::: ..:.::::::::: 
CCDS53 VNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPP
             180       190       200       210       220       230 

      380       390       400       410       420       430        
pF1KB4 GCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWI
       ::.::.:::: :: ::::::..:::.::.::.::::::::::::::::.:: ::::::::
CCDS53 GCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWI
             240       250       260       270       280       290 

      440       450       460       
pF1KB4 EIHLHGPLQWLDKVLTQMGSPHNPISSVS
       :.::.::::::::::::::::    ::::
CCDS53 ELHLNGPLQWLDKVLTQMGSPSIRCSSVS
             300       310       320

>>CCDS45288.1 SMAD3 gene_id:4088|Hs108|chr15              (381 aa)
 initn: 1371 init1: 898 opt: 1153  Z-score: 792.5  bits: 155.7 E(32554): 8e-38
Smith-Waterman score: 1593; 60.9% identity (77.8% similar) in 396 aa overlap (73-467:25-381)

             50        60        70        80        90       100  
pF1KB4 KKLKKKKGAMDELERALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQ
                                     ::::::::::::::::::::::.::::::.
CCDS45       MSCLHPRQTWKGAALVHRKAWWMGRSLDGRLQVSHRKGLPHVIYCRLWRWPDLH
                     10        20        30        40        50    

            110       120       130       140       150       160  
pF1KB4 SHHELKPLECCEFPFGSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRS
       :::::. .: ::: :. :. :::.:::::.:::::::::::::::.:   ..  :  .  
CCDS45 SHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYS-
           60        70        80        90       100       110    

            170       180       190       200       210       220  
pF1KB4 ASLHSEPLMPHNATYPDSFQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQH
          ::   .:.:...: ...  : : .: .:             :  ::  ::     .:
CCDS45 ---HS---IPENTNFPAGIE--PQSNIPETP-------------P--PGYLSEDGETSDH
                 120         130                      140       150

            230        240       250       260       270       280 
pF1KB4 SVDTPPLPYHATEA-SETQSGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYEL
       ...      :. .: : . : .:.. . .        : :..:: : ::  :::..::::
CCDS45 QMN------HSMDAGSPNLSPNPMSPAHN--------NLDLQPVTYCEPAFWCSISYYEL
                    160       170               180       190      

             290       300       310       320       330       340 
pF1KB4 NNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYV
       :.::::::.::. :. .::::::::.. :::::::::::::...: ::::::.::.:::.
CCDS45 NQRVGETFHASQPSMTVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYI
        200       210       220        230       240       250     

             350       360       370       380       390       400 
pF1KB4 GGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHG
       ::::.:::.:::.::::: ::: ..:.::::::::: ::.::.:::: :: ::::::..:
CCDS45 GGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQG
         260       270       280       290       300       310     

             410       420       430       440       450       460 
pF1KB4 FEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHN
       ::.::.::.::::::::::::::::.:: :::::::::.::.::::::::::::::::  
CCDS45 FEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSI
         320       330       340       350       360       370     

             
pF1KB4 PISSVS
         ::::
CCDS45 RCSSVS
         380 

>>CCDS10222.1 SMAD3 gene_id:4088|Hs108|chr15              (425 aa)
 initn: 1559 init1: 898 opt: 1153  Z-score: 791.8  bits: 155.7 E(32554): 8.8e-38
Smith-Waterman score: 1852; 60.6% identity (77.8% similar) in 465 aa overlap (7-467:1-425)

               10        20           30        40        50       
pF1KB4 MHSTTPISSLFSFTSPAVKRLLGWKQGDE---EEKWAEKAVDSLVKKLKKKKGAMDELER
             .::.. :: : ::::::::.:..   :::: :::: ::::::::  : .::::.
CCDS10       MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKT-GQLDELEK
                     10        20        30        40         50   

        60        70        80        90       100       110       
pF1KB4 ALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPF
       :..  .  .::.:::::::::::::::::::::::::.::::::.:::::. .: ::: :
CCDS10 AITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAF
            60        70        80        90       100       110   

       120       130       140       150       160       170       
pF1KB4 GSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATY
       . :. :::.:::::.:::::::::::::::.:   ..  :  .     ::   .:.:...
CCDS10 NMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYS----HS---IPENTNF
           120       130       140       150              160      

       180       190       200       210       220       230       
pF1KB4 PDSFQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEA-
       : ...  : : .: .:             :  ::  ::     .:...      :. .: 
CCDS10 PAGIE--PQSNIPETP-------------P--PGYLSEDGETSDHQMN------HSMDAG
        170         180                      190             200   

        240       250       260       270       280       290      
pF1KB4 SETQSGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSV
       : . : .:.. . .        : :..:: : ::  :::..:::::.::::::.::. :.
CCDS10 SPNLSPNPMSPAHN--------NLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSM
           210               220       230       240       250     

        300       310       320       330       340       350      
pF1KB4 LIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIF
        .::::::::.. :::::::::::::...: ::::::.::.:::.::::.:::.:::.::
CCDS10 TVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIF
         260        270       280       290       300       310    

        360       370       380       390       400       410      
pF1KB4 VQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRM
       ::: ::: ..:.::::::::: ::.::.:::: :: ::::::..:::.::.::.::::::
CCDS10 VQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRM
          320       330       340       350       360       370    

        420       430       440       450       460       
pF1KB4 SFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
       ::::::::::.:: :::::::::.::.::::::::::::::::    ::::
CCDS10 SFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
          380       390       400       410       420     

>>CCDS53951.1 SMAD3 gene_id:4088|Hs108|chr15              (230 aa)
 initn: 963 init1: 898 opt: 1113  Z-score: 769.0  bits: 150.6 E(32554): 1.6e-36
Smith-Waterman score: 1113; 75.1% identity (90.9% similar) in 209 aa overlap (259-467:23-230)

      230       240       250       260       270       280        
pF1KB4 LPYHATEASETQSGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGET
                                     : :..:: : ::  :::..:::::.:::::
CCDS53         MNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGET
                       10        20        30        40        50  

      290       300       310       320       330       340        
pF1KB4 FQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAE
       :.::. :. .::::::::.. :::::::::::::...: ::::::.::.:::.::::.::
CCDS53 FHASQPSMTVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAE
             60        70         80        90       100       110 

      350       360       370       380       390       400        
pF1KB4 CVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYEL
       :.:::.::::: ::: ..:.::::::::: ::.::.:::: :: ::::::..:::.::.:
CCDS53 CLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQL
             120       130       140       150       160       170 

      410       420       430       440       450       460       
pF1KB4 TKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
       :.::::::::::::::::.:: :::::::::.::.::::::::::::::::    ::::
CCDS53 TRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
             180       190       200       210       220       230

>>CCDS11950.1 SMAD4 gene_id:4089|Hs108|chr18              (552 aa)
 initn: 741 init1: 231 opt: 493  Z-score: 347.4  bits: 73.8 E(32554): 5e-13
Smith-Waterman score: 794; 36.1% identity (59.5% similar) in 457 aa overlap (3-397:7-451)

                   10        20        30        40        50      
pF1KB4     MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELE
             ..:: :.   ..   :. :.  .:: : : .:..:..:::::::.::  .: : 
CCDS11 MDNMSITNTPTSNDACLS--IVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLI
               10          20        30        40        50        

         60         70        80        90       100       110     
pF1KB4 RALSCPG-QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEF
        :..  : .::::::: :.:::::::. :::.::::: :.::::::... ::: .. :..
CCDS11 TAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKN-ELKHVKYCQY
       60        70        80        90       100        110       

         120       130                  140          150       160 
pF1KB4 PFGSKQKEVCINPYHYRRVETPVL-----------PPVLVPRHS---EYNPQLSLLAKFR
        :  :   ::.:::::.:: .: .           :  .. .     ... : :: .. .
CCDS11 AFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGH
       120       130       140       150       160       170       

             170       180       190       200       210        220
pF1KB4 SASLHSEPLMPHNATYPDSFQQPPCSALPPSPSHAFSQSPCTASYPHSP-GSPSEPESPY
       : .  ..:  : : .  .... :  . : :: :.: :    ::..:. : .: :.: :  
CCDS11 SIQTIQHP--PSNRASTETYSTP--ALLAPSESNATS----TANFPNIPVASTSQPASIL
       180         190         200       210           220         

                     230                    240       250          
pF1KB4 --QHS-----VDTPPLP-------------YHATEASETQSGQPVDATAD----------
         .::     . . : :             :: . ..   ... .  : .          
CCDS11 GGSHSEGLLQIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQ
     230       240       250       260       270       280         

              260                  270       280       290         
pF1KB4 RHVVLSIPNGDFRPVCYE-----------EPQHWCSVAYYELNNRVGETFQASSRS--VL
       .:  .    : . ::  :            :..:::.::.:.. .:::::.. :    : 
CCDS11 HHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVT
     290       300       310       320       330       340         

       300       310       320       330       340        350      
pF1KB4 IDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAECVSDSSIF
       .::..:::.. .::::: ::::.:. .:: .: ::::::.:   : :.:...:.:: ..:
CCDS11 VDGYVDPSGG-DRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVF
     350        360       370       380       390       400        

        360       370        380        390       400       410    
pF1KB4 VQSRNCNYQHGFHPA-TVCKIPSGCSLKVFN-NQLFAQLLAQSVHHGFEVVYELTKMCTI
       :::   . . :  :. .: ::  .  .:::.  :   :.  :.                 
CCDS11 VQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGN
      410       420       430       440       450       460        

          420       430       440       450       460              
pF1KB4 RMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS       
                                                                   
CCDS11 IPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIH
      470       480       490       500       510       520        




467 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 03:01:25 2016 done: Fri Nov  4 03:01:26 2016
 Total Scan time:  2.870 Total Display time:  0.050

Function used was FASTA [36.3.4 Apr, 2011]
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