FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4505, 1172 aa 1>>>pF1KB4505 1172 - 1172 aa - 1172 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2956+/-0.000541; mu= 13.2933+/- 0.033 mean_var=230.1766+/-44.348, 0's: 0 Z-trim(114.3): 480 B-trim: 0 in 0/55 Lambda= 0.084536 statistics sampled from 23478 (24099) to 23478 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.631), E-opt: 0.2 (0.283), width: 16 Scan time: 13.680 The best scores are: opt bits E(85289) NP_003238 (OMIM: 188061,603932) thrombospondin-2 p (1172) 8548 1057.7 0 NP_003237 (OMIM: 188060) thrombospondin-1 precurso (1170) 5584 696.2 3.2e-199 XP_011520273 (OMIM: 188060) PREDICTED: thrombospon (1112) 4215 529.2 5.6e-149 NP_000086 (OMIM: 132400,177170,600310) cartilage o ( 757) 2464 315.4 8.6e-85 NP_001239537 (OMIM: 188062) thrombospondin-3 isofo ( 836) 2422 310.3 3.2e-83 XP_011508238 (OMIM: 188062) PREDICTED: thrombospon ( 704) 2420 310.0 3.4e-83 NP_001239536 (OMIM: 188062) thrombospondin-3 isofo ( 947) 2422 310.4 3.4e-83 NP_009043 (OMIM: 188062) thrombospondin-3 isoform ( 956) 2422 310.4 3.4e-83 XP_006711561 (OMIM: 188062) PREDICTED: thrombospon (1013) 2422 310.4 3.6e-83 XP_011508237 (OMIM: 188062) PREDICTED: thrombospon ( 780) 2420 310.1 3.6e-83 XP_011508236 (OMIM: 188062) PREDICTED: thrombospon ( 780) 2420 310.1 3.6e-83 XP_011508235 (OMIM: 188062) PREDICTED: thrombospon ( 921) 2420 310.1 4e-83 XP_011508233 (OMIM: 188062) PREDICTED: thrombospon ( 921) 2420 310.1 4e-83 XP_011508234 (OMIM: 188062) PREDICTED: thrombospon ( 921) 2420 310.1 4e-83 XP_011508231 (OMIM: 188062) PREDICTED: thrombospon ( 959) 2420 310.2 4.1e-83 XP_011508230 (OMIM: 188062) PREDICTED: thrombospon ( 985) 2420 310.2 4.2e-83 XP_011508229 (OMIM: 188062) PREDICTED: thrombospon (1007) 2420 310.2 4.2e-83 XP_011508228 (OMIM: 188062) PREDICTED: thrombospon (1016) 2420 310.2 4.2e-83 NP_001293142 (OMIM: 600715) thrombospondin-4 isofo ( 870) 2403 308.0 1.6e-82 NP_001293141 (OMIM: 600715) thrombospondin-4 isofo ( 870) 2403 308.0 1.6e-82 NP_001293143 (OMIM: 600715) thrombospondin-4 isofo ( 870) 2403 308.0 1.6e-82 NP_003239 (OMIM: 600715) thrombospondin-4 isoform ( 961) 2403 308.1 1.7e-82 XP_011508232 (OMIM: 188062) PREDICTED: thrombospon ( 954) 2245 288.8 1.1e-76 XP_016857695 (OMIM: 188062) PREDICTED: thrombospon ( 488) 2098 270.5 1.8e-71 XP_016865288 (OMIM: 600715) PREDICTED: thrombospon ( 656) 905 125.2 1.4e-27 XP_016865289 (OMIM: 600715) PREDICTED: thrombospon ( 637) 896 124.1 2.8e-27 XP_016865287 (OMIM: 600715) PREDICTED: thrombospon ( 663) 896 124.1 2.9e-27 XP_011515504 (OMIM: 602682) PREDICTED: brain-speci (1161) 610 89.5 1.3e-16 NP_001693 (OMIM: 602682) brain-specific angiogenes (1584) 610 89.7 1.6e-16 XP_011515501 (OMIM: 602682) PREDICTED: brain-speci (1584) 610 89.7 1.6e-16 XP_016869185 (OMIM: 602682) PREDICTED: brain-speci (1618) 610 89.7 1.6e-16 XP_016869184 (OMIM: 602682) PREDICTED: brain-speci (1623) 610 89.7 1.6e-16 XP_016869183 (OMIM: 602682) PREDICTED: brain-speci (1630) 610 89.7 1.6e-16 XP_016869181 (OMIM: 602682) PREDICTED: brain-speci (1662) 610 89.7 1.6e-16 XP_016869180 (OMIM: 602682) PREDICTED: brain-speci (1663) 610 89.7 1.6e-16 XP_016866633 (OMIM: 602684) PREDICTED: adhesion G ( 813) 587 86.5 7.3e-16 XP_016866632 (OMIM: 602684) PREDICTED: adhesion G ( 827) 587 86.5 7.4e-16 XP_016866631 (OMIM: 602684) PREDICTED: adhesion G ( 869) 587 86.6 7.6e-16 XP_011534314 (OMIM: 602684) PREDICTED: adhesion G ( 908) 587 86.6 7.8e-16 XP_011534311 (OMIM: 602684) PREDICTED: adhesion G (1267) 587 86.8 9.6e-16 XP_016866629 (OMIM: 602684) PREDICTED: adhesion G (1489) 587 86.9 1.1e-15 XP_006715597 (OMIM: 602684) PREDICTED: adhesion G (1489) 587 86.9 1.1e-15 XP_005248809 (OMIM: 602684) PREDICTED: adhesion G (1522) 587 86.9 1.1e-15 NP_001695 (OMIM: 602684) adhesion G protein-couple (1522) 587 86.9 1.1e-15 XP_016869186 (OMIM: 602682) PREDICTED: brain-speci (1608) 585 86.7 1.3e-15 XP_016869182 (OMIM: 602682) PREDICTED: brain-speci (1660) 566 84.4 6.7e-15 NP_002612 (OMIM: 300383,312060) properdin precurso ( 469) 539 80.4 3e-14 NP_001138724 (OMIM: 300383,312060) properdin precu ( 469) 539 80.4 3e-14 XP_016857395 (OMIM: 602683) PREDICTED: adhesion G (1533) 539 81.0 6.2e-14 XP_016857394 (OMIM: 602683) PREDICTED: adhesion G (1551) 539 81.0 6.3e-14 >>NP_003238 (OMIM: 188061,603932) thrombospondin-2 precu (1172 aa) initn: 8548 init1: 8548 opt: 8548 Z-score: 5651.3 bits: 1057.7 E(85289): 0 Smith-Waterman score: 8548; 100.0% identity (100.0% similar) in 1172 aa overlap (1-1172:1-1172) 10 20 30 40 50 60 pF1KB4 MVWRLVLLALWVWPSTQAGHQDKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MVWRLVLLALWVWPSTQAGHQDKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 DYIPPVNADDLSKITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DYIPPVNADDLSKITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 ADTLDLTYWIDGTRHVVSLEDVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEPFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ADTLDLTYWIDGTRHVVSLEDVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEPFY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 EHLQAEKSRMYVAKGSARESHFRGLLQNVHLVFENSVEDILSKKGCQQGQGAEINAISEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EHLQAEKSRMYVAKGSARESHFRGLLQNVHLVFENSVEDILSKKGCQQGQGAEINAISEN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 TETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQELSGLHVLVNQLSENLKRVSND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQELSGLHVLVNQLSENLKRVSND 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 NQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 ASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 QTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 RETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQER 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB4 QMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDI 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB4 CFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 CFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCH 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB4 KHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB4 PHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB4 YVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB4 VHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB4 DNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFR 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB4 NFQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NFQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDR 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB4 DDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRN 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB4 ALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPI 1090 1100 1110 1120 1130 1140 1150 1160 1170 pF1KB4 YDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI :::::::::::::::::::::::::::::::: NP_003 YDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI 1150 1160 1170 >>NP_003237 (OMIM: 188060) thrombospondin-1 precursor [H (1170 aa) initn: 5438 init1: 4961 opt: 5584 Z-score: 3697.7 bits: 696.2 E(85289): 3.2e-199 Smith-Waterman score: 5618; 61.7% identity (83.0% similar) in 1176 aa overlap (1-1171:3-1169) 10 20 30 40 50 pF1KB4 MVWRL-VLLALWVWPSTQAGHQDKDTT-FDLFSISNINRKTIGAKQFRGPDPGVPAYR ..: : ::. . : ... .. :.. ::.: ... :: : . .::::. ::.: NP_003 MGLAWGLGVLFLMHVCGTNRIPESGGDNSVFDIFELTGAARKGSGRRLVKGPDPSSPAFR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 FVRFDYIPPVNADDLSKITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIV . . :::: : .. .. .: ..::.: :.:.: :.:::::::: : . : .: NP_003 IEDANLIPPVPDDKFQDLVDAVRAEKGFLLLASLRQMKKTRGTLLALERKDHSGQVFSVV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 SNGPADTLDLTYWIDGTRHVVSLEDVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALD ::: : ::::. ..: .::::.:.. :: .:::..:. : . .:.. :. ... :: NP_003 SNGKAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELD 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB4 EPF---YEHLQAEKSRMYVAKGSARESHFRGLLQNVHLVFENSVEDILSKKGCQQGQGAE :. . . : .:. .:::.. .. :.:.::::..:: .. :::: .:::... .. NP_003 VPIQSVFTRDLASIARLRIAKGGVNDN-FQGVLQNVRFVFGTTPEDILRNKGCSSSTSVL 190 200 210 220 230 240 250 260 270 280 290 pF1KB4 INAISENTETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQELSGLHVLVNQLSEN .. .:. . .: . :.:.: ... .: ::.::..:: :: ::...:. :... NP_003 LTL--DNNVVNGSSPAIRTNYIGHKTKDLQAICGISCDELSSMVLELRGLRTIVTTLQDS 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB4 LKRVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTICHQI ...:...:. : . . :: :...: . .:: :.::::: : :.. :::... NP_003 IRKVTEENKELANELRRPP------LCYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKV 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB4 TCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSN .:: :.. . .::::: : : ....:::::.:::.::..::.: :::::::: .: NP_003 SCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNN 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB4 TCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGG : : :.:::.: ...:: :..::::::::::::::::::: : :::::::::: :::.: NP_003 RCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNG 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB4 KNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKAC : :.: .::::::. :::.: :.:::::. :.:::.::...:.:.::.: ::.::: : NP_003 KPCEGEARETKACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDC 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB4 VGDVQERQMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDE :::: : :.:::..::.::::::::: :..:.:.:::::.::.:: :. ::: .: :.:: NP_003 VGDVTENQICNKQDCPIDGCLSNPCFAGVKCTSYPDGSWKCGACPPGYSGNGIQCTDVDE 540 550 560 570 580 590 600 610 620 630 640 650 pF1KB4 CALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCK : ::: ::. . :: ::.::..:::::::. :.:: : :.: : ..::::.:.::: NP_003 CKEVPDACFNHNGEHRCENTDPGYNCLPCPPRFTGSQPFGQGVEHATANKQVCKPRNPCT 600 610 620 630 640 650 660 670 680 690 700 710 pF1KB4 DKTHNCHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATY : ::.:.:.:.: ::::.:::::.:::. ::::.:.:::::.::::::: ::::..:::: NP_003 DGTHDCNKNAKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATY 660 670 680 690 700 710 720 730 740 750 760 770 pF1KB4 HCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVG :: :::::.::::::::.:::::::::::::::: . :..::: . .:: : :::.:.:: NP_003 HCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVG 720 730 740 750 760 770 780 790 800 810 820 830 pF1KB4 DRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGD :::::::: ::: : :::::::::::..::::: ..:::::: ::::.:::::: ::::: NP_003 DRCDNCPYNHNPDQADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQRDTDMDGVGD 780 790 800 810 820 830 840 850 860 870 880 890 pF1KB4 HCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQG .:::::: ::::: : :.: .:: ::::.:::.:::::: :::::. ::::::::.::.: NP_003 QCDNCPLEHNPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKG 840 850 860 870 880 890 900 910 920 930 940 950 pF1KB4 DACDPDDDNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNA :::: ::::::.:::.:::::: ::::.: ::::::: ::::::.:..:::::.:::: NP_003 DACDHDDDNDGIPDDKDNCRLVPNPDQKDSDGDGRGDACKDDFDHDSVPDIDDICPENVD 900 910 920 930 940 950 960 970 980 990 1000 1010 pF1KB4 ISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGT ::::::: :::.:::::::.: :::::.::::::::::.: :::.:::.:::..:::::: NP_003 ISETDFRRFQMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGT 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KB4 FYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTG :..::.::::::::::::::::::::::::::::.::. .:::: ::::.:.:::::::: NP_003 FFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTG 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 pF1KB4 TGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQV ::::::::::::::::::::::::::.:::::.:::::.:.::::::.:::...:::.. NP_003 PGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKI 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 pF1KB4 MADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI :::::::::.:::::::::::::::::.:::::::::: NP_003 MADSGPIYDKTYAGGRLGLFVFSQEMVFFSDLKYECRDP 1140 1150 1160 1170 >>XP_011520273 (OMIM: 188060) PREDICTED: thrombospondin- (1112 aa) initn: 5083 init1: 3773 opt: 4215 Z-score: 2795.6 bits: 529.2 E(85289): 5.6e-149 Smith-Waterman score: 5151; 58.6% identity (78.6% similar) in 1176 aa overlap (1-1171:3-1111) 10 20 30 40 50 pF1KB4 MVWRL-VLLALWVWPSTQAGHQDKDTT-FDLFSISNINRKTIGAKQFRGPDPGVPAYR ..: : ::. . : ... .. :.. ::.: ... :: : . .::::. ::.: XP_011 MGLAWGLGVLFLMHVCGTNRIPESGGDNSVFDIFELTGAARKGSGRRLVKGPDPSSPAFR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 FVRFDYIPPVNADDLSKITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIV . . :::: : .. .. .: ..::.: :.:.: :.:::::::: : . : .: XP_011 IEDANLIPPVPDDKFQDLVDAVRAEKGFLLLASLRQMKKTRGTLLALERKDHSGQVFSVV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 SNGPADTLDLTYWIDGTRHVVSLEDVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALD ::: : ::::. ..: .::::.:.. :: .:::..:. : . .:.. :. ... :: XP_011 SNGKAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELD 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB4 EPF---YEHLQAEKSRMYVAKGSARESHFRGLLQNVHLVFENSVEDILSKKGCQQGQGAE :. . . : .:. .:::.. .. :.:.::::..:: .. :::: .:::... .. XP_011 VPIQSVFTRDLASIARLRIAKGGVNDN-FQGVLQNVRFVFGTTPEDILRNKGCSSSTSVL 190 200 210 220 230 240 250 260 270 280 290 pF1KB4 INAISENTETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQELSGLHVLVNQLSEN .. .:. . .: . :.:.: ... .: ::.::..:: :: ::...:. :... XP_011 LTL--DNNVVNGSSPAIRTNYIGHKTKDLQAICGISCDELSSMVLELRGLRTIVTTLQDS 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB4 LKRVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTICHQI ...:...:. : . . :: :...: . .:: :.::::: : :.. :::... XP_011 IRKVTEENKELANELRRPP------LCYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKV 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB4 TCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSN .:: :.. . .::::: : : ....:::::.:::.::..::.: :::::::: .: XP_011 SCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNN 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB4 TCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGG : : :.:::.: ...:: :..::::::::::::::::::: : :::::::::: :::.: XP_011 RCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNG 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB4 KNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKAC : :.: .::::::. :: XP_011 KPCEGEARETKACKKDACP----------------------------------------- 480 490 540 550 560 570 580 590 pF1KB4 VGDVQERQMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDE .:::::::: :..:.:.:::::.::.:: :. ::: .: :.:: XP_011 -----------------NGCLSNPCFAGVKCTSYPDGSWKCGACPPGYSGNGIQCTDVDE 500 510 520 530 600 610 620 630 640 650 pF1KB4 CALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCK : ::: ::. . :: ::.::..:::::::. :.:: : :.: : ..::::.:.::: XP_011 CKEVPDACFNHNGEHRCENTDPGYNCLPCPPRFTGSQPFGQGVEHATANKQVCKPRNPCT 540 550 560 570 580 590 660 670 680 690 700 710 pF1KB4 DKTHNCHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATY : ::.:.:.:.: ::::.:::::.:::. ::::.:.:::::.::::::: ::::..:::: XP_011 DGTHDCNKNAKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATY 600 610 620 630 640 650 720 730 740 750 760 770 pF1KB4 HCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVG :: :::::.::::::::.:::::::::::::::: . :..::: . .:: : :::.:.:: XP_011 HCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVG 660 670 680 690 700 710 780 790 800 810 820 830 pF1KB4 DRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGD :::::::: ::: : :::::::::::..::::: ..:::::: ::::.:::::: ::::: XP_011 DRCDNCPYNHNPDQADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQRDTDMDGVGD 720 730 740 750 760 770 840 850 860 870 880 890 pF1KB4 HCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQG .:::::: ::::: : :.: .:: ::::.:::.:::::: :::::. ::::::::.::.: XP_011 QCDNCPLEHNPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKG 780 790 800 810 820 830 900 910 920 930 940 950 pF1KB4 DACDPDDDNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNA :::: ::::::.:::.:::::: ::::.: ::::::: ::::::.:..:::::.:::: XP_011 DACDHDDDNDGIPDDKDNCRLVPNPDQKDSDGDGRGDACKDDFDHDSVPDIDDICPENVD 840 850 860 870 880 890 960 970 980 990 1000 1010 pF1KB4 ISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGT ::::::: :::.:::::::.: :::::.::::::::::.: :::.:::.:::..:::::: XP_011 ISETDFRRFQMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGT 900 910 920 930 940 950 1020 1030 1040 1050 1060 1070 pF1KB4 FYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTG :..::.::::::::::::::::::::::::::::.::. .:::: ::::.:.:::::::: XP_011 FFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTG 960 970 980 990 1000 1010 1080 1090 1100 1110 1120 1130 pF1KB4 TGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQV ::::::::::::::::::::::::::.:::::.:::::.:.::::::.:::...:::.. XP_011 PGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKI 1020 1030 1040 1050 1060 1070 1140 1150 1160 1170 pF1KB4 MADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI :::::::::.:::::::::::::::::.:::::::::: XP_011 MADSGPIYDKTYAGGRLGLFVFSQEMVFFSDLKYECRDP 1080 1090 1100 1110 >>NP_000086 (OMIM: 132400,177170,600310) cartilage oligo (757 aa) initn: 3056 init1: 2182 opt: 2464 Z-score: 1643.3 bits: 315.4 E(85289): 8.6e-85 Smith-Waterman score: 2632; 54.3% identity (71.3% similar) in 669 aa overlap (549-1171:87-743) 520 530 540 550 560 570 pF1KB4 RVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCP :. : . ::::. : . .:. :: :: NP_000 REITFLKNTVMECDACGMQQSVRTGLPSVRPLLHCAPGFCFPGVACIQTESGA-RCGPCP 60 70 80 90 100 110 580 590 600 610 620 630 pF1KB4 VGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEA .:: :::.:: :..:: : :: .: ::.::.:::.: ::: : : :::: NP_000 AGFTGNGSHCTDVNECNAHP--CFP--RV-RCINTSPGFRCEACPPGYSGPTHQGVGLAF 120 130 140 150 160 170 640 650 pF1KB4 AKTEKQVCEPENPCKDKTHNC--------------------------------------- ::..:::: : :. ::: NP_000 AKANKQVCTDINECETGQHNCVPNSVCINTRGSFQCGPCQPGFVGDQASGCQRRAQRFCP 180 190 200 210 220 230 660 670 680 690 700 710 pF1KB4 -------HKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNAT :.::.:. : .: : .:.::.:..::.:.::::.:. .: : NP_000 DGSPSECHEHADCVLE---RDGSRSCVCAVGWAGNGILCGRDTDLDGFPDEKLRCPE--- 240 250 260 270 280 720 730 740 750 760 770 pF1KB4 YHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEV .: :::: .::::::: :.:::::::: : :.::: .::::: :. :: : . :.:. NP_000 RQCRKDNCVTVPNSGQEDVDRDGIGDACDPDADGDGVPNEKDNCPLVRNPDQRNTDEDKW 290 300 310 320 330 340 780 790 800 810 820 830 pF1KB4 GDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVG :: :::: .: : :::..:.::::. ::::: . :. :::: : :.::.:.::::.: NP_000 GDACDNCRSQKNDDQKDTDQDGRGDACDDDIDGDRIRNQADNCPRVPNSDQKDSDGDGIG 350 360 370 380 390 400 840 850 860 870 880 890 pF1KB4 DHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQ : ::::: ::::.:::.:.::: ::...: : ::::...:::: . :. : : :.::: NP_000 DACDNCPQKSNPDQADVDHDFVGDACDSDQDQDGDGHQDSRDNCPTVPNSAQEDSDHDGQ 410 420 430 440 450 460 900 910 920 930 940 950 pF1KB4 GDACDPDDDNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENN ::::: :::::::::.::::::: :: ::: : :: ::.:.:::: :.. : :::::: NP_000 GDACDDDDDNDGVPDSRDNCRLVPNPGQEDADRDGVGDVCQDDFDADKVVDKIDVCPENA 470 480 490 500 510 520 960 970 980 990 1000 1010 pF1KB4 AISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSG .. :::: :: : :::.: .:::::::. .::.:.::: :::::.:::. :..::: : NP_000 EVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGREIVQTMNSDPGLAVGYTAFNGVDFEG 530 540 550 560 570 580 1020 1030 1040 1050 1060 1070 pF1KB4 TFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTT ::.::: :::::::.::::.:: ::::::::. ::::. .: :: . :..::.:.:.: NP_000 TFHVNTVTDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSST 590 600 610 620 630 640 1080 1090 1100 1110 1120 1130 pF1KB4 GTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQ : ::.:::::::::.: .::: ::.::::.:::: .::: : :::..::::: .:: . NP_000 GPGEQLRNALWHTGDTESQVRLLWKDPRNVGWKDKKSYRWFLQHRPQVGYIRVRFYEGPE 650 660 670 680 690 700 1140 1150 1160 1170 pF1KB4 VMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI ..:::. . : :. :::::.: :::: . ...:.:.: : NP_000 LVADSNVVLDTTMRGGRLGVFCFSQENIIWANLRYRCNDTIPEDYETHQLRQA 710 720 730 740 750 >>NP_001239537 (OMIM: 188062) thrombospondin-3 isoform 3 (836 aa) initn: 2137 init1: 1243 opt: 2422 Z-score: 1615.1 bits: 310.3 E(85289): 3.2e-83 Smith-Waterman score: 2562; 52.2% identity (69.9% similar) in 688 aa overlap (537-1171:143-818) 510 520 530 540 550 560 pF1KB4 TVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCN---KRSCPVDGCLSNPCFPGAQ ..: :.:. .:: : :::: :.. NP_001 TQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRS----HCSPNPCFRGVD 120 130 140 150 160 570 580 590 600 610 620 pF1KB4 CSS-FPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPC : . .. :: :: :. :::::: :..::: . : :: :. :.::.::::: : NP_001 CMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHA-DPCFPGSS---CINTMPGFHCEAC 170 180 190 200 210 220 630 640 pF1KB4 PPRYRGNQPVGVGLEAAKTEKQVCE----------------------------------- : :.:.: :::.. :.. ::::. NP_001 PRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF 230 240 250 260 270 280 650 660 670 680 690 pF1KB4 ---------PENPCKDKTHN-CHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDL : :.. .:. :: ::.:.. . .:.:..:.::.: .:: :.:. NP_001 LGNQSQGCLPARTCHSPAHSPCHIHAHCLFE---RNGAVSCQCNVGWAGNGNVCGTDTDI 290 300 310 320 330 340 700 710 720 730 740 750 pF1KB4 DGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQ ::.:. : : : . :: .::: ::::::: :.::.:: :::: :.::. . .:::. NP_001 DGYPDQALPCMDN-NKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCR 350 360 370 380 390 400 760 770 780 790 800 810 pF1KB4 LLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPY :. : : . : : :: ::::: : : : :::.:::::::. :.::: . : :::: NP_001 LFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPK 410 420 430 440 450 460 820 830 840 850 860 870 pF1KB4 VYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCP : : : : : ::::: ::.:: . :: :::.:.::::: ::.::: : ::::...:::: NP_001 VPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDVCDTNEDSDGDGHQDTKDNCP 470 480 490 500 510 520 880 890 900 910 920 930 pF1KB4 YISNANQADHDRDGQGDACDPDDDNDGVPD----DRDNCRLVFNPDQEDLDGDGRGDICK . :..: : : :: :: :: ::::::.:: :::::: ::.:.: ::.: ::.:. NP_001 QLPNSSQLDSDNDGLGDECDGDDDNDGIPDYVPPGPDNCRLVPNPNQKDSDGNGVGDVCE 530 540 550 560 570 580 940 950 960 970 980 990 pF1KB4 DDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELVQTAN :::::: . : :::::. .. :::: .: : :::.: .:::::::. .:: :.::: : NP_001 DDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMN 590 600 610 620 630 640 1000 1010 1020 1030 1040 1050 pF1KB4 SDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQ ::::.:::. :..::: :::.::: :::::::.:.::.:.:::::::::. ::::. NP_001 SDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQAT 650 660 670 680 690 700 1060 1070 1080 1090 1100 1110 pF1KB4 PTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWH : :: . :..::.:.:..: ::::::::::::.:: ::: :: ::::.::.: :.:::. NP_001 PFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGHTPDQVRLLWTDPRNVGWRDKTSYRWQ 710 720 730 740 750 760 1120 1130 1140 1150 1160 1170 pF1KB4 LTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI : :::..::::: ..:: :..:::: : : .. :::::.: :::: . .:.:.:.: : NP_001 LLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCNDTV 770 780 790 800 810 820 NP_001 PEDFEPFRRQLLQGRV 830 >>XP_011508238 (OMIM: 188062) PREDICTED: thrombospondin- (704 aa) initn: 1829 init1: 1243 opt: 2420 Z-score: 1614.7 bits: 310.0 E(85289): 3.4e-83 Smith-Waterman score: 2541; 51.8% identity (69.6% similar) in 691 aa overlap (537-1171:8-686) 510 520 530 540 550 560 pF1KB4 TVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCN---KRSCPVDGCLSNPCFPGAQ ..: :.:. .:: : :::: :.. XP_011 MSLIRNTIMECQVCGFHEQRS----HCSPNPCFRGVD 10 20 30 570 580 590 600 610 620 pF1KB4 CSS-FPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPC : . .. :: :: :. :::::: :..::: . : :: :. :.::.::::: : XP_011 CMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHA-DPCFPGSS---CINTMPGFHCEAC 40 50 60 70 80 630 640 pF1KB4 PPRYRGNQPVGVGLEAAKTEKQVCE----------------------------------- : :.:.: :::.. :.. ::::. XP_011 PRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF 90 100 110 120 130 140 650 660 670 680 690 pF1KB4 ---------PENPCKDKTHN-CHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDL : :.. .:. :: ::.:.. . .:.:..:.::.: .:: :.:. XP_011 LGNQSQGCLPARTCHSPAHSPCHIHAHCLFE---RNGAVSCQCNVGWAGNGNVCGTDTDI 150 160 170 180 190 200 700 710 720 730 740 750 pF1KB4 DGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQ ::.:. : : : . :: .::: ::::::: :.::.:: :::: :.::. . .:::. XP_011 DGYPDQALPCMDN-NKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCR 210 220 230 240 250 260 760 770 780 790 800 810 pF1KB4 LLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPY :. : : . : : :: ::::: : : : :::.:::::::. :.::: . : :::: XP_011 LFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPK 270 280 290 300 310 320 820 830 840 850 860 870 pF1KB4 VYNTDQRDTDGDGVGDHCDNCPLVHNPDQT---DVDNDLVGDQCDNNEDIDDDGHQNNQD : : : : : ::::: ::.:: . :: :. :.:.::::: ::.::: : ::::...: XP_011 VPNPLQTDRDEDGVGDACDSCPEMSNPTQVQGDDADSDLVGDVCDTNEDSDGDGHQDTKD 330 340 350 360 370 380 880 890 900 910 920 930 pF1KB4 NCPYISNANQADHDRDGQGDACDPDDDNDGVPD----DRDNCRLVFNPDQEDLDGDGRGD ::: . :..: : : :: :: :: ::::::.:: :::::: ::.:.: ::.: :: XP_011 NCPQLPNSSQLDSDNDGLGDECDGDDDNDGIPDYVPPGPDNCRLVPNPNQKDSDGNGVGD 390 400 410 420 430 440 940 950 960 970 980 990 pF1KB4 ICKDDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELVQ .:.:::::: . : :::::. .. :::: .: : :::.: .:::::::. .:: :.:: XP_011 VCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQ 450 460 470 480 490 500 1000 1010 1020 1030 1040 1050 pF1KB4 TANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYW : :::::.:::. :..::: :::.::: :::::::.:.::.:.:::::::::. :::: XP_011 TMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYW 510 520 530 540 550 560 1060 1070 1080 1090 1100 1110 pF1KB4 EDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAY . : :: . :..::.:.:..: ::::::::::::.:: ::: :: ::::.::.: :.: XP_011 QATPFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGHTPDQVRLLWTDPRNVGWRDKTSY 570 580 590 600 610 620 1120 1130 1140 1150 1160 1170 pF1KB4 RWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECR ::.: :::..::::: ..:: :..:::: : : .. :::::.: :::: . .:.:.:.: XP_011 RWQLLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCN 630 640 650 660 670 680 pF1KB4 DI : XP_011 DTVPEDFEPFRRQLLQGRV 690 700 >>NP_001239536 (OMIM: 188062) thrombospondin-3 isoform 2 (947 aa) initn: 2137 init1: 1243 opt: 2422 Z-score: 1614.5 bits: 310.4 E(85289): 3.4e-83 Smith-Waterman score: 2562; 52.2% identity (69.9% similar) in 688 aa overlap (537-1171:254-929) 510 520 530 540 550 560 pF1KB4 TVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCN---KRSCPVDGCLSNPCFPGAQ ..: :.:. .:: : :::: :.. NP_001 TQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRS----HCSPNPCFRGVD 230 240 250 260 270 570 580 590 600 610 620 pF1KB4 CSS-FPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPC : . .. :: :: :. :::::: :..::: . : :: :. :.::.::::: : NP_001 CMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHA-DPCFPGSS---CINTMPGFHCEAC 280 290 300 310 320 330 630 640 pF1KB4 PPRYRGNQPVGVGLEAAKTEKQVCE----------------------------------- : :.:.: :::.. :.. ::::. NP_001 PRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF 340 350 360 370 380 390 650 660 670 680 690 pF1KB4 ---------PENPCKDKTHN-CHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDL : :.. .:. :: ::.:.. . .:.:..:.::.: .:: :.:. NP_001 LGNQSQGCLPARTCHSPAHSPCHIHAHCLFE---RNGAVSCQCNVGWAGNGNVCGTDTDI 400 410 420 430 440 450 700 710 720 730 740 750 pF1KB4 DGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQ ::.:. : : : . :: .::: ::::::: :.::.:: :::: :.::. . .:::. NP_001 DGYPDQALPCMDN-NKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCR 460 470 480 490 500 510 760 770 780 790 800 810 pF1KB4 LLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPY :. : : . : : :: ::::: : : : :::.:::::::. :.::: . : :::: NP_001 LFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPK 520 530 540 550 560 570 820 830 840 850 860 870 pF1KB4 VYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCP : : : : : ::::: ::.:: . :: :::.:.::::: ::.::: : ::::...:::: NP_001 VPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDVCDTNEDSDGDGHQDTKDNCP 580 590 600 610 620 630 880 890 900 910 920 930 pF1KB4 YISNANQADHDRDGQGDACDPDDDNDGVPD----DRDNCRLVFNPDQEDLDGDGRGDICK . :..: : : :: :: :: ::::::.:: :::::: ::.:.: ::.: ::.:. NP_001 QLPNSSQLDSDNDGLGDECDGDDDNDGIPDYVPPGPDNCRLVPNPNQKDSDGNGVGDVCE 640 650 660 670 680 690 940 950 960 970 980 990 pF1KB4 DDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELVQTAN :::::: . : :::::. .. :::: .: : :::.: .:::::::. .:: :.::: : NP_001 DDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMN 700 710 720 730 740 750 1000 1010 1020 1030 1040 1050 pF1KB4 SDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQ ::::.:::. :..::: :::.::: :::::::.:.::.:.:::::::::. ::::. NP_001 SDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQAT 760 770 780 790 800 810 1060 1070 1080 1090 1100 1110 pF1KB4 PTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWH : :: . :..::.:.:..: ::::::::::::.:: ::: :: ::::.::.: :.:::. NP_001 PFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGHTPDQVRLLWTDPRNVGWRDKTSYRWQ 820 830 840 850 860 870 1120 1130 1140 1150 1160 1170 pF1KB4 LTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI : :::..::::: ..:: :..:::: : : .. :::::.: :::: . .:.:.:.: : NP_001 LLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCNDTV 880 890 900 910 920 930 NP_001 PEDFEPFRRQLLQGRV 940 >>NP_009043 (OMIM: 188062) thrombospondin-3 isoform 1 pr (956 aa) initn: 2137 init1: 1243 opt: 2422 Z-score: 1614.5 bits: 310.4 E(85289): 3.4e-83 Smith-Waterman score: 2562; 52.2% identity (69.9% similar) in 688 aa overlap (537-1171:263-938) 510 520 530 540 550 560 pF1KB4 TVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCN---KRSCPVDGCLSNPCFPGAQ ..: :.:. .:: : :::: :.. NP_009 TQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRS----HCSPNPCFRGVD 240 250 260 270 280 570 580 590 600 610 620 pF1KB4 CSS-FPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPC : . .. :: :: :. :::::: :..::: . : :: :. :.::.::::: : NP_009 CMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHA-DPCFPGSS---CINTMPGFHCEAC 290 300 310 320 330 340 630 640 pF1KB4 PPRYRGNQPVGVGLEAAKTEKQVCE----------------------------------- : :.:.: :::.. :.. ::::. NP_009 PRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF 350 360 370 380 390 400 650 660 670 680 690 pF1KB4 ---------PENPCKDKTHN-CHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDL : :.. .:. :: ::.:.. . .:.:..:.::.: .:: :.:. NP_009 LGNQSQGCLPARTCHSPAHSPCHIHAHCLFE---RNGAVSCQCNVGWAGNGNVCGTDTDI 410 420 430 440 450 460 700 710 720 730 740 750 pF1KB4 DGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQ ::.:. : : : . :: .::: ::::::: :.::.:: :::: :.::. . .:::. NP_009 DGYPDQALPCMDN-NKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCR 470 480 490 500 510 520 760 770 780 790 800 810 pF1KB4 LLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPY :. : : . : : :: ::::: : : : :::.:::::::. :.::: . : :::: NP_009 LFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPK 530 540 550 560 570 580 820 830 840 850 860 870 pF1KB4 VYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCP : : : : : ::::: ::.:: . :: :::.:.::::: ::.::: : ::::...:::: NP_009 VPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDVCDTNEDSDGDGHQDTKDNCP 590 600 610 620 630 640 880 890 900 910 920 930 pF1KB4 YISNANQADHDRDGQGDACDPDDDNDGVPD----DRDNCRLVFNPDQEDLDGDGRGDICK . :..: : : :: :: :: ::::::.:: :::::: ::.:.: ::.: ::.:. NP_009 QLPNSSQLDSDNDGLGDECDGDDDNDGIPDYVPPGPDNCRLVPNPNQKDSDGNGVGDVCE 650 660 670 680 690 700 940 950 960 970 980 990 pF1KB4 DDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELVQTAN :::::: . : :::::. .. :::: .: : :::.: .:::::::. .:: :.::: : NP_009 DDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMN 710 720 730 740 750 760 1000 1010 1020 1030 1040 1050 pF1KB4 SDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQ ::::.:::. :..::: :::.::: :::::::.:.::.:.:::::::::. ::::. NP_009 SDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQAT 770 780 790 800 810 820 1060 1070 1080 1090 1100 1110 pF1KB4 PTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWH : :: . :..::.:.:..: ::::::::::::.:: ::: :: ::::.::.: :.:::. NP_009 PFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGHTPDQVRLLWTDPRNVGWRDKTSYRWQ 830 840 850 860 870 880 1120 1130 1140 1150 1160 1170 pF1KB4 LTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI : :::..::::: ..:: :..:::: : : .. :::::.: :::: . .:.:.:.: : NP_009 LLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCNDTV 890 900 910 920 930 940 NP_009 PEDFEPFRRQLLQGRV 950 >>XP_006711561 (OMIM: 188062) PREDICTED: thrombospondin- (1013 aa) initn: 2137 init1: 1243 opt: 2422 Z-score: 1614.2 bits: 310.4 E(85289): 3.6e-83 Smith-Waterman score: 2562; 52.2% identity (69.9% similar) in 688 aa overlap (537-1171:320-995) 510 520 530 540 550 560 pF1KB4 TVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCN---KRSCPVDGCLSNPCFPGAQ ..: :.:. .:: : :::: :.. XP_006 TQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRS----HCSPNPCFRGVD 290 300 310 320 330 340 570 580 590 600 610 620 pF1KB4 CSS-FPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPC : . .. :: :: :. :::::: :..::: . : :: :. :.::.::::: : XP_006 CMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHA-DPCFPGSS---CINTMPGFHCEAC 350 360 370 380 390 400 630 640 pF1KB4 PPRYRGNQPVGVGLEAAKTEKQVCE----------------------------------- : :.:.: :::.. :.. ::::. XP_006 PRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF 410 420 430 440 450 460 650 660 670 680 690 pF1KB4 ---------PENPCKDKTHN-CHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDL : :.. .:. :: ::.:.. . .:.:..:.::.: .:: :.:. XP_006 LGNQSQGCLPARTCHSPAHSPCHIHAHCLFE---RNGAVSCQCNVGWAGNGNVCGTDTDI 470 480 490 500 510 700 710 720 730 740 750 pF1KB4 DGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQ ::.:. : : : . :: .::: ::::::: :.::.:: :::: :.::. . .:::. XP_006 DGYPDQALPCMDN-NKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCR 520 530 540 550 560 570 760 770 780 790 800 810 pF1KB4 LLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPY :. : : . : : :: ::::: : : : :::.:::::::. :.::: . : :::: XP_006 LFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPK 580 590 600 610 620 630 820 830 840 850 860 870 pF1KB4 VYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCP : : : : : ::::: ::.:: . :: :::.:.::::: ::.::: : ::::...:::: XP_006 VPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDVCDTNEDSDGDGHQDTKDNCP 640 650 660 670 680 690 880 890 900 910 920 930 pF1KB4 YISNANQADHDRDGQGDACDPDDDNDGVPD----DRDNCRLVFNPDQEDLDGDGRGDICK . :..: : : :: :: :: ::::::.:: :::::: ::.:.: ::.: ::.:. XP_006 QLPNSSQLDSDNDGLGDECDGDDDNDGIPDYVPPGPDNCRLVPNPNQKDSDGNGVGDVCE 700 710 720 730 740 750 940 950 960 970 980 990 pF1KB4 DDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELVQTAN :::::: . : :::::. .. :::: .: : :::.: .:::::::. .:: :.::: : XP_006 DDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMN 760 770 780 790 800 810 1000 1010 1020 1030 1040 1050 pF1KB4 SDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQ ::::.:::. :..::: :::.::: :::::::.:.::.:.:::::::::. ::::. XP_006 SDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYWQAT 820 830 840 850 860 870 1060 1070 1080 1090 1100 1110 pF1KB4 PTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWH : :: . :..::.:.:..: ::::::::::::.:: ::: :: ::::.::.: :.:::. XP_006 PFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGHTPDQVRLLWTDPRNVGWRDKTSYRWQ 880 890 900 910 920 930 1120 1130 1140 1150 1160 1170 pF1KB4 LTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI : :::..::::: ..:: :..:::: : : .. :::::.: :::: . .:.:.:.: : XP_006 LLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCNDTV 940 950 960 970 980 990 XP_006 PEDFEPFRRQLLQGRV 1000 1010 >>XP_011508237 (OMIM: 188062) PREDICTED: thrombospondin- (780 aa) initn: 1829 init1: 1243 opt: 2420 Z-score: 1614.2 bits: 310.1 E(85289): 3.6e-83 Smith-Waterman score: 2541; 51.8% identity (69.6% similar) in 691 aa overlap (537-1171:84-762) 510 520 530 540 550 560 pF1KB4 TVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCN---KRSCPVDGCLSNPCFPGAQ ..: :.:. .:: : :::: :.. XP_011 TQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRS----HCSPNPCFRGVD 60 70 80 90 100 570 580 590 600 610 620 pF1KB4 CSS-FPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPC : . .. :: :: :. :::::: :..::: . : :: :. :.::.::::: : XP_011 CMEVYEYPGYRCGPCPPGLQGNGTHCSDINECAHA-DPCFPGSS---CINTMPGFHCEAC 110 120 130 140 150 160 630 640 pF1KB4 PPRYRGNQPVGVGLEAAKTEKQVCE----------------------------------- : :.:.: :::.. :.. ::::. XP_011 PRGYKGTQVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTVGSFKCGPCRLGF 170 180 190 200 210 220 650 660 670 680 690 pF1KB4 ---------PENPCKDKTHN-CHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDL : :.. .:. :: ::.:.. . .:.:..:.::.: .:: :.:. XP_011 LGNQSQGCLPARTCHSPAHSPCHIHAHCLFE---RNGAVSCQCNVGWAGNGNVCGTDTDI 230 240 250 260 270 280 700 710 720 730 740 750 pF1KB4 DGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQ ::.:. : : : . :: .::: ::::::: :.::.:: :::: :.::. . .:::. XP_011 DGYPDQALPCMDN-NKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDADGDGIKNVEDNCR 290 300 310 320 330 340 760 770 780 790 800 810 pF1KB4 LLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPY :. : : . : : :: ::::: : : : :::.:::::::. :.::: . : :::: XP_011 LFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDVDGDGIPNGLDNCPK 350 360 370 380 390 400 820 830 840 850 860 870 pF1KB4 VYNTDQRDTDGDGVGDHCDNCPLVHNPDQT---DVDNDLVGDQCDNNEDIDDDGHQNNQD : : : : : ::::: ::.:: . :: :. :.:.::::: ::.::: : ::::...: XP_011 VPNPLQTDRDEDGVGDACDSCPEMSNPTQVQGDDADSDLVGDVCDTNEDSDGDGHQDTKD 410 420 430 440 450 460 880 890 900 910 920 930 pF1KB4 NCPYISNANQADHDRDGQGDACDPDDDNDGVPD----DRDNCRLVFNPDQEDLDGDGRGD ::: . :..: : : :: :: :: ::::::.:: :::::: ::.:.: ::.: :: XP_011 NCPQLPNSSQLDSDNDGLGDECDGDDDNDGIPDYVPPGPDNCRLVPNPNQKDSDGNGVGD 470 480 490 500 510 520 940 950 960 970 980 990 pF1KB4 ICKDDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELVQ .:.:::::: . : :::::. .. :::: .: : :::.: .:::::::. .:: :.:: XP_011 VCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQ 530 540 550 560 570 580 1000 1010 1020 1030 1040 1050 pF1KB4 TANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYW : :::::.:::. :..::: :::.::: :::::::.:.::.:.:::::::::. :::: XP_011 TMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSYQDSGRFYVVMWKQTEQTYW 590 600 610 620 630 640 1060 1070 1080 1090 1100 1110 pF1KB4 EDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAY . : :: . :..::.:.:..: ::::::::::::.:: ::: :: ::::.::.: :.: XP_011 QATPFRAVAQPGLQLKAVTSVSGPGEHLRNALWHTGHTPDQVRLLWTDPRNVGWRDKTSY 650 660 670 680 690 700 1120 1130 1140 1150 1160 1170 pF1KB4 RWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECR ::.: :::..::::: ..:: :..:::: : : .. :::::.: :::: . .:.:.:.: XP_011 RWQLLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRGGRLGVFCFSQENIIWSNLQYRCN 710 720 730 740 750 760 pF1KB4 DI : XP_011 DTVPEDFEPFRRQLLQGRV 770 780 1172 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 21:35:48 2016 done: Thu Nov 3 21:35:50 2016 Total Scan time: 13.680 Total Display time: 0.360 Function used was FASTA [36.3.4 Apr, 2011]