FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4596, 917 aa 1>>>pF1KB4596 917 - 917 aa - 917 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7133+/-0.000562; mu= 24.3151+/- 0.035 mean_var=65.6075+/-13.097, 0's: 0 Z-trim(105.4): 65 B-trim: 0 in 0/49 Lambda= 0.158342 statistics sampled from 13617 (13641) to 13617 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.478), E-opt: 0.2 (0.16), width: 16 Scan time: 10.630 The best scores are: opt bits E(85289) NP_000179 (OMIM: 142600,235700,605285) hexokinase- ( 917) 6027 1387.1 0 NP_001309293 (OMIM: 142600,235700,605285) hexokina ( 921) 5898 1357.6 0 NP_277033 (OMIM: 142600,235700,605285) hexokinase- ( 921) 5898 1357.6 0 NP_277032 (OMIM: 142600,235700,605285) hexokinase- ( 921) 5898 1357.6 0 NP_001309294 (OMIM: 142600,235700,605285) hexokina ( 952) 5898 1357.6 0 XP_011538034 (OMIM: 142600,235700,605285) PREDICTE ( 905) 5897 1357.4 0 NP_277035 (OMIM: 142600,235700,605285) hexokinase- ( 905) 5897 1357.4 0 NP_277031 (OMIM: 142600,235700,605285) hexokinase- ( 916) 5897 1357.4 0 NP_001309295 (OMIM: 142600,235700,605285) hexokina ( 889) 5852 1347.1 0 XP_005269794 (OMIM: 142600,235700,605285) PREDICTE ( 889) 5852 1347.1 0 NP_001309296 (OMIM: 142600,235700,605285) hexokina ( 885) 4739 1092.8 0 NP_000180 (OMIM: 601125) hexokinase-2 [Homo sapien ( 917) 4668 1076.6 0 XP_016859434 (OMIM: 601125) PREDICTED: hexokinase- ( 885) 3767 870.8 0 NP_002106 (OMIM: 142570) hexokinase-3 [Homo sapien ( 923) 3202 741.7 3.8e-213 XP_016864900 (OMIM: 142570) PREDICTED: hexokinase- ( 866) 3190 739.0 2.4e-212 XP_005264337 (OMIM: 601125) PREDICTED: hexokinase- ( 938) 3007 697.2 9.8e-200 XP_011531109 (OMIM: 601125) PREDICTED: hexokinase- ( 906) 2106 491.3 8.7e-138 XP_011532842 (OMIM: 142570) PREDICTED: hexokinase- ( 642) 1826 427.3 1.2e-118 NP_277043 (OMIM: 125851,125853,138079,602485,60617 ( 464) 1709 400.4 1.1e-110 NP_000153 (OMIM: 125851,125853,138079,602485,60617 ( 465) 1705 399.5 2e-110 XP_016867455 (OMIM: 125851,125853,138079,602485,60 ( 456) 1703 399.0 2.7e-110 NP_277042 (OMIM: 125851,125853,138079,602485,60617 ( 466) 1696 397.4 8.3e-110 >>NP_000179 (OMIM: 142600,235700,605285) hexokinase-1 is (917 aa) initn: 6027 init1: 6027 opt: 6027 Z-score: 7435.5 bits: 1387.1 E(85289): 0 Smith-Waterman score: 6027; 100.0% identity (100.0% similar) in 917 aa overlap (1-917:1-917) 10 20 30 40 50 60 pF1KB4 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB4 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB4 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB4 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB4 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB4 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB4 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 850 860 870 880 890 900 910 pF1KB4 AALITAVGVRLRTEASS ::::::::::::::::: NP_000 AALITAVGVRLRTEASS 910 >>NP_001309293 (OMIM: 142600,235700,605285) hexokinase-1 (921 aa) initn: 5898 init1: 5898 opt: 5898 Z-score: 7276.2 bits: 1357.6 E(85289): 0 Smith-Waterman score: 5898; 99.9% identity (100.0% similar) in 897 aa overlap (21-917:25-921) 10 20 30 40 50 pF1KB4 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFN .::::::::::::::::::::::::::::::::::: NP_001 MGQICQRESATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 PTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 NIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB4 ASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB4 CYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKM 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB4 VSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEIL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB4 TRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSL 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB4 YKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAH 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB4 FHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGT 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB4 NFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRM 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB4 PLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVN 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB4 DTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNG 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB4 CLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETL 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB4 KTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGA 790 800 810 820 830 840 840 850 860 870 880 890 pF1KB4 GMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDG 850 860 870 880 890 900 900 910 pF1KB4 SGKGAALITAVGVRLRTEASS ::::::::::::::::::::: NP_001 SGKGAALITAVGVRLRTEASS 910 920 >>NP_277033 (OMIM: 142600,235700,605285) hexokinase-1 is (921 aa) initn: 5898 init1: 5898 opt: 5898 Z-score: 7276.2 bits: 1357.6 E(85289): 0 Smith-Waterman score: 5898; 99.9% identity (100.0% similar) in 897 aa overlap (21-917:25-921) 10 20 30 40 50 pF1KB4 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFN .::::::::::::::::::::::::::::::::::: NP_277 MGQICQRESATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 PTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 PTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 NIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 NIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB4 ASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 ASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB4 CYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 CYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKM 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB4 VSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 VSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEIL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB4 TRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 TRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSL 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB4 YKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 YKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAH 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB4 FHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 FHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGT 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB4 NFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 NFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRM 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB4 PLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 PLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVN 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB4 DTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 DTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNG 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB4 CLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 CLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETL 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB4 KTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 KTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGA 790 800 810 820 830 840 840 850 860 870 880 890 pF1KB4 GMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 GMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDG 850 860 870 880 890 900 900 910 pF1KB4 SGKGAALITAVGVRLRTEASS ::::::::::::::::::::: NP_277 SGKGAALITAVGVRLRTEASS 910 920 >>NP_277032 (OMIM: 142600,235700,605285) hexokinase-1 is (921 aa) initn: 5898 init1: 5898 opt: 5898 Z-score: 7276.2 bits: 1357.6 E(85289): 0 Smith-Waterman score: 5898; 99.9% identity (100.0% similar) in 897 aa overlap (21-917:25-921) 10 20 30 40 50 pF1KB4 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFN .::::::::::::::::::::::::::::::::::: NP_277 MGQICQRESATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 PTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 PTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 NIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 NIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB4 ASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 ASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB4 CYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 CYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKM 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB4 VSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 VSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEIL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB4 TRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 TRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSL 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB4 YKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 YKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAH 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB4 FHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 FHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGT 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB4 NFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 NFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRM 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB4 PLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 PLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVN 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB4 DTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 DTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNG 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB4 CLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 CLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETL 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB4 KTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 KTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGA 790 800 810 820 830 840 840 850 860 870 880 890 pF1KB4 GMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 GMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDG 850 860 870 880 890 900 900 910 pF1KB4 SGKGAALITAVGVRLRTEASS ::::::::::::::::::::: NP_277 SGKGAALITAVGVRLRTEASS 910 920 >>NP_001309294 (OMIM: 142600,235700,605285) hexokinase-1 (952 aa) initn: 5898 init1: 5898 opt: 5898 Z-score: 7276.0 bits: 1357.6 E(85289): 0 Smith-Waterman score: 5898; 99.9% identity (100.0% similar) in 897 aa overlap (21-917:56-952) 10 20 30 40 50 pF1KB4 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNG .::::::::::::::::::::::::::::: NP_001 QVILLPQPPKVLGLQATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNG 30 40 50 60 70 80 60 70 80 90 100 110 pF1KB4 LSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESE 90 100 110 120 130 140 120 130 140 150 160 170 pF1KB4 VYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILIT 150 160 170 180 190 200 180 190 200 210 220 230 pF1KB4 WTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLII 210 220 230 240 250 260 240 250 260 270 280 290 pF1KB4 GTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGK 270 280 290 300 310 320 300 310 320 330 340 350 pF1KB4 QLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLH 330 340 350 360 370 380 360 370 380 390 400 410 pF1KB4 NAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTV 390 400 410 420 430 440 420 430 440 450 460 470 pF1KB4 GVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQI 450 460 470 480 490 500 480 490 500 510 520 530 pF1KB4 EETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLA 510 520 530 540 550 560 540 550 560 570 580 590 pF1KB4 LDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMG 570 580 590 600 610 620 600 610 620 630 640 650 pF1KB4 IKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLD 630 640 650 660 670 680 660 670 680 690 700 710 pF1KB4 VVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWG 690 700 710 720 730 740 720 730 740 750 760 770 pF1KB4 AFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRG 750 760 770 780 790 800 780 790 800 810 820 830 pF1KB4 QISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRA 810 820 830 840 850 860 840 850 860 870 880 890 pF1KB4 AQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSF 870 880 890 900 910 920 900 910 pF1KB4 LLSEDGSGKGAALITAVGVRLRTEASS ::::::::::::::::::::::::::: NP_001 LLSEDGSGKGAALITAVGVRLRTEASS 930 940 950 >>XP_011538034 (OMIM: 142600,235700,605285) PREDICTED: h (905 aa) initn: 5897 init1: 5897 opt: 5897 Z-score: 7275.0 bits: 1357.4 E(85289): 0 Smith-Waterman score: 5897; 100.0% identity (100.0% similar) in 896 aa overlap (22-917:10-905) 10 20 30 40 50 60 pF1KB4 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT ::::::::::::::::::::::::::::::::::::::: XP_011 MAKRALHDFIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 10 20 30 40 70 80 90 100 110 120 pF1KB4 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB4 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB4 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB4 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB4 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB4 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB4 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB4 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB4 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB4 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB4 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 650 660 670 680 690 700 730 740 750 760 770 780 pF1KB4 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 710 720 730 740 750 760 790 800 810 820 830 840 pF1KB4 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 770 780 790 800 810 820 850 860 870 880 890 900 pF1KB4 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 830 840 850 860 870 880 910 pF1KB4 AALITAVGVRLRTEASS ::::::::::::::::: XP_011 AALITAVGVRLRTEASS 890 900 >>NP_277035 (OMIM: 142600,235700,605285) hexokinase-1 is (905 aa) initn: 5897 init1: 5897 opt: 5897 Z-score: 7275.0 bits: 1357.4 E(85289): 0 Smith-Waterman score: 5897; 100.0% identity (100.0% similar) in 896 aa overlap (22-917:10-905) 10 20 30 40 50 60 pF1KB4 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT ::::::::::::::::::::::::::::::::::::::: NP_277 MAKRALHDFIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 10 20 30 40 70 80 90 100 110 120 pF1KB4 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB4 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB4 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB4 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB4 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB4 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB4 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB4 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB4 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB4 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB4 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 650 660 670 680 690 700 730 740 750 760 770 780 pF1KB4 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 710 720 730 740 750 760 790 800 810 820 830 840 pF1KB4 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 770 780 790 800 810 820 850 860 870 880 890 900 pF1KB4 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 830 840 850 860 870 880 910 pF1KB4 AALITAVGVRLRTEASS ::::::::::::::::: NP_277 AALITAVGVRLRTEASS 890 900 >>NP_277031 (OMIM: 142600,235700,605285) hexokinase-1 is (916 aa) initn: 5897 init1: 5897 opt: 5897 Z-score: 7275.0 bits: 1357.4 E(85289): 0 Smith-Waterman score: 5897; 100.0% identity (100.0% similar) in 896 aa overlap (22-917:21-916) 10 20 30 40 50 60 pF1KB4 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT ::::::::::::::::::::::::::::::::::::::: NP_277 MDCEHSLSLPCRGAEAWEIGIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB4 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB4 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB4 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB4 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB4 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB4 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 420 430 440 450 460 470 490 500 510 520 530 540 pF1KB4 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 480 490 500 510 520 530 550 560 570 580 590 600 pF1KB4 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB4 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB4 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 660 670 680 690 700 710 730 740 750 760 770 780 pF1KB4 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 720 730 740 750 760 770 790 800 810 820 830 840 pF1KB4 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 780 790 800 810 820 830 850 860 870 880 890 900 pF1KB4 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 840 850 860 870 880 890 910 pF1KB4 AALITAVGVRLRTEASS ::::::::::::::::: NP_277 AALITAVGVRLRTEASS 900 910 >>NP_001309295 (OMIM: 142600,235700,605285) hexokinase-1 (889 aa) initn: 5852 init1: 5852 opt: 5852 Z-score: 7219.6 bits: 1347.1 E(85289): 0 Smith-Waterman score: 5852; 100.0% identity (100.0% similar) in 889 aa overlap (29-917:1-889) 10 20 30 40 50 60 pF1KB4 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT :::::::::::::::::::::::::::::::: NP_001 MRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 10 20 30 70 80 90 100 110 120 pF1KB4 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB4 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB4 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB4 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB4 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB4 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB4 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB4 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB4 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 520 530 540 550 560 570 610 620 630 640 650 660 pF1KB4 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 580 590 600 610 620 630 670 680 690 700 710 720 pF1KB4 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 640 650 660 670 680 690 730 740 750 760 770 780 pF1KB4 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 700 710 720 730 740 750 790 800 810 820 830 840 pF1KB4 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 760 770 780 790 800 810 850 860 870 880 890 900 pF1KB4 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 820 830 840 850 860 870 910 pF1KB4 AALITAVGVRLRTEASS ::::::::::::::::: NP_001 AALITAVGVRLRTEASS 880 >>XP_005269794 (OMIM: 142600,235700,605285) PREDICTED: h (889 aa) initn: 5852 init1: 5852 opt: 5852 Z-score: 7219.6 bits: 1347.1 E(85289): 0 Smith-Waterman score: 5852; 100.0% identity (100.0% similar) in 889 aa overlap (29-917:1-889) 10 20 30 40 50 60 pF1KB4 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT :::::::::::::::::::::::::::::::: XP_005 MRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 10 20 30 70 80 90 100 110 120 pF1KB4 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB4 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB4 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB4 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB4 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB4 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB4 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB4 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB4 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 520 530 540 550 560 570 610 620 630 640 650 660 pF1KB4 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 580 590 600 610 620 630 670 680 690 700 710 720 pF1KB4 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 640 650 660 670 680 690 730 740 750 760 770 780 pF1KB4 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 700 710 720 730 740 750 790 800 810 820 830 840 pF1KB4 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 760 770 780 790 800 810 850 860 870 880 890 900 pF1KB4 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 820 830 840 850 860 870 910 pF1KB4 AALITAVGVRLRTEASS ::::::::::::::::: XP_005 AALITAVGVRLRTEASS 880 917 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 15:14:38 2016 done: Thu Nov 3 15:14:39 2016 Total Scan time: 10.630 Total Display time: 0.350 Function used was FASTA [36.3.4 Apr, 2011]