FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4618, 746 aa 1>>>pF1KB4618 746 - 746 aa - 746 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1949+/-0.00084; mu= 14.7729+/- 0.051 mean_var=65.2324+/-13.269, 0's: 0 Z-trim(105.9): 25 B-trim: 0 in 0/51 Lambda= 0.158797 statistics sampled from 8659 (8671) to 8659 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.631), E-opt: 0.2 (0.266), width: 16 Scan time: 3.330 The best scores are: opt bits E(32554) CCDS53618.1 EXT2 gene_id:2132|Hs108|chr11 ( 751) 4961 1145.6 0 CCDS7908.1 EXT2 gene_id:2132|Hs108|chr11 ( 718) 4882 1127.5 0 CCDS53619.1 EXT2 gene_id:2132|Hs108|chr11 ( 728) 2641 614.1 2.4e-175 CCDS6070.1 EXTL3 gene_id:2137|Hs108|chr8 ( 919) 915 218.7 3.3e-56 CCDS271.1 EXTL1 gene_id:2134|Hs108|chr1 ( 676) 850 203.8 7.4e-52 CCDS6324.1 EXT1 gene_id:2131|Hs108|chr8 ( 746) 735 177.4 7e-44 CCDS775.1 EXTL2 gene_id:2135|Hs108|chr1 ( 330) 411 103.2 6.9e-22 >>CCDS53618.1 EXT2 gene_id:2132|Hs108|chr11 (751 aa) initn: 4952 init1: 4952 opt: 4961 Z-score: 6133.6 bits: 1145.6 E(32554): 0 Smith-Waterman score: 4961; 99.1% identity (99.2% similar) in 738 aa overlap (11-746:14-751) 10 20 30 40 50 pF1KB4 MVVPRSSLLWPRCCVRPG--ECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYI : : .: ::::::::::::::::::::::::::::::::::::: CCDS53 MSCASGSGGGLRHPLRCQKPWDEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 TLFSIVLLGLIATGMFQFWPHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 TLFSIVLLGLIATGMFQFWPHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRM 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 HTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 HTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDI 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB4 NRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 NRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPR 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB4 DRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 DRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYRE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB4 DLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVLRGARLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 DLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVLRGARLG 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB4 QAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 QAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEE 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB4 MQRQARWFWEAYFQSIKAIALATLQIINDRIYPYAAISYEEWNDPPAVKWGSVSNPLFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 MQRQARWFWEAYFQSIKAIALATLQIINDRIYPYAAISYEEWNDPPAVKWGSVSNPLFLP 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB4 LIPPQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 LIPPQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRV 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB4 PLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 PLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYP 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB4 GRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 GRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCE 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB4 DIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 DIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTM 670 680 690 700 710 720 720 730 740 pF1KB4 PLKVVEHRADPVLYKDDFPEKLKSFPNIGSL ::::::::::::::::::::::::::::::: CCDS53 PLKVVEHRADPVLYKDDFPEKLKSFPNIGSL 730 740 750 >>CCDS7908.1 EXT2 gene_id:2132|Hs108|chr11 (718 aa) initn: 4882 init1: 4882 opt: 4882 Z-score: 6036.2 bits: 1127.5 E(32554): 0 Smith-Waterman score: 4882; 100.0% identity (100.0% similar) in 718 aa overlap (29-746:1-718) 10 20 30 40 50 60 pF1KB4 MVVPRSSLLWPRCCVRPGECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSI :::::::::::::::::::::::::::::::: CCDS79 MCASVKYNIRGPALIPRMKTKHRIYYITLFSI 10 20 30 70 80 90 100 110 120 pF1KB4 VLLGLIATGMFQFWPHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 VLLGLIATGMFQFWPHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFD 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB4 VYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDINRACL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 VYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDINRACL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB4 FVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 FVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALL 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB4 AGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 AGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEAL 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB4 QVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVLRGARLGQAVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 QVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVLRGARLGQAVLS 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB4 DVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 DVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQA 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB4 RWFWEAYFQSIKAIALATLQIINDRIYPYAAISYEEWNDPPAVKWGSVSNPLFLPLIPPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 RWFWEAYFQSIKAIALATLQIINDRIYPYAAISYEEWNDPPAVKWGSVSNPLFLPLIPPQ 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB4 SQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRVPLKVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 SQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRVPLKVV 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB4 RTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYPGRLHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 RTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYPGRLHL 520 530 540 550 560 570 610 620 630 640 650 660 pF1KB4 WDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 WDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMN 580 590 600 610 620 630 670 680 690 700 710 720 pF1KB4 FLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS79 FLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVV 640 650 660 670 680 690 730 740 pF1KB4 EHRADPVLYKDDFPEKLKSFPNIGSL :::::::::::::::::::::::::: CCDS79 EHRADPVLYKDDFPEKLKSFPNIGSL 700 710 >>CCDS53619.1 EXT2 gene_id:2132|Hs108|chr11 (728 aa) initn: 4733 init1: 2641 opt: 2641 Z-score: 3261.4 bits: 614.1 E(32554): 2.4e-175 Smith-Waterman score: 4716; 96.3% identity (97.1% similar) in 728 aa overlap (29-746:1-728) 10 20 30 40 50 60 pF1KB4 MVVPRSSLLWPRCCVRPGECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSI :::::::::::::::::::::::::::::::: CCDS53 MCASVKYNIRGPALIPRMKTKHRIYYITLFSI 10 20 30 70 80 90 100 110 120 pF1KB4 VLLGLIATGMFQFWPHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 VLLGLIATGMFQFWPHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFD 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB4 VYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDINRACL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 VYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDINRACL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB4 FVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 FVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALL 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB4 AGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 AGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEAL 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB4 QVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVLRGARLGQAVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 QVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVLRGARLGQAVLS 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB4 DVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 DVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQL 340 350 360 370 380 390 430 440 450 460 470 pF1KB4 ------RWFWEAYFQSIKAIALATLQ----IINDRIYPYAAISYEEWNDPPAVKWGSVSN : : : ...... : :::::::::::::::::::::::::::::: CCDS53 FMEPARRENWSAANHQMNSLIWPREQWDSQIINDRIYPYAAISYEEWNDPPAVKWGSVSN 400 410 420 430 440 450 480 490 500 510 520 530 pF1KB4 PLFLPLIPPQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 PLFLPLIPPQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLW 460 470 480 490 500 510 540 550 560 570 580 590 pF1KB4 PKIRVPLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 PKIRVPLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDR 520 530 540 550 560 570 600 610 620 630 640 650 pF1KB4 LVGYPGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 LVGYPGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDA 580 590 600 610 620 630 660 670 680 690 700 710 pF1KB4 HMNCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 HMNCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFAS 640 650 660 670 680 690 720 730 740 pF1KB4 VFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGSL :::::::::::::::::::::::::::::::::::: CCDS53 VFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGSL 700 710 720 >>CCDS6070.1 EXTL3 gene_id:2137|Hs108|chr8 (919 aa) initn: 1126 init1: 496 opt: 915 Z-score: 1122.6 bits: 218.7 E(32554): 3.3e-56 Smith-Waterman score: 1216; 33.0% identity (57.9% similar) in 776 aa overlap (94-740:155-916) 70 80 90 100 110 120 pF1KB4 GLIATGMFQFWPHSIESSNDWNVEKRSIRDVPVVRLPA--DSPIPE-RGDLSCRMHTCFD .:. :: :. .: .. .::.:.::: CCDS60 KQDLLQLKNVISQTEHSYKELMAQNQPKLSLPIRLLPEKDDAGLPPPKATRGCRLHNCFD 130 140 150 160 170 180 130 140 150 160 170 180 pF1KB4 VYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDINRACL :: .. . . ::.: ..: :: .. ... .. : . : :.. . ::: CCDS60 YSRCPLT--SGFPVYVYDSDQFV--FGSYLDPLVKQAFQATARA---NVYVTENADIACL 190 200 210 220 230 190 200 210 220 230 pF1KB4 FVPSIDVLNQNT-LRIKETAQAMAQLSRWDR-GTNHLLFNMLPGGPPDYNTALDVPRDRA .: . ... . :: : . . .: .: : ::...: : : .: :: CCDS60 YVILVGEMQEPVVLRPAELEKQLYSLPHWRTDGHNHVIIN-LSRKSDTQNLLYNVSTGRA 240 250 260 270 280 290 240 250 260 270 280 pF1KB4 LLAGGGFSTWTYRQGYDVSI-PVYSPLSAE--VDLPEKGPGPRQYFL---------LSSQ ..: . : : :: :.:. . :. .: ...: . : :.:.. : :. CCDS60 MVAQSTFYTVQYRPGFDLVVSPLVHAMSEPNFMEIPPQVPVKRKYLFTFQGEKIESLRSS 300 310 320 330 340 350 290 300 310 320 pF1KB4 V-----------GLHPEYRED-----LEALQVKHGESVLVLDKCTNLSEGVLSVR-KRCH . : : .: :.:.: .. ..::: : : . : .. : CCDS60 LQEARSFEEEMEGDPPADYDDRIIATLKAVQDSKLDQVLVEFTCKNQPKPSLPTEWALCG 360 370 380 390 400 410 330 340 350 360 370 380 pF1KB4 KHQVFDYPQVLQEATFCVVLRGA--RL----GQAV-LSDVLQAGCVPVVIADSYILPFSE ... : ..:. .:: ... . :: : :. : ..:..: ::::.... ::... CCDS60 ERE--DRLELLKLSTFALIITPGDPRLVISSGCATRLFEALEVGAVPVVLGEQVQLPYQD 420 430 440 450 460 470 390 400 410 420 430 440 pF1KB4 VLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQARWFWEAYFQSIKAIALATLQII .:.:..:..:::. ....:. .:.:. . .. :.::.:..::.::.. .: ..: .: CCDS60 MLQWNEAALVVPKPRVTEVHFLLRSLSDSDLLAMRRQGRFLWETYFSTADSIFNTVLAMI 480 490 500 510 520 530 450 460 pF1KB4 NDRIYPYAAISYEEW------------------------------NDPPAVK-------- :: :: :: ..:: .. CCDS60 RTRIQIPAAPIREEAAAEIPHRSGKAAGTDPNMADNGDLDLGPVETEPPYASPRYLRNFT 540 550 560 570 580 590 470 480 pF1KB4 ---------WGSVSNPLFL-------PLIP-------------PQSQG------------ :. . .:. : :..: : . : CCDS60 LTVTDFYRSWNCAPGPFHLFPHTPFDPVLPSEAKFLGSGTGFRPIGGGAGGSGKEFQAAL 600 610 620 630 640 650 490 500 510 520 530 pF1KB4 --------FTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRV ::...:::.: : :. . ... .: :.:..::::. : : :: ::: : : CCDS60 GGNVPREQFTVVMLTYEREEVLMNSLERLNGLPYLNKVVVVWNSP-KLPSEDLLWPDIGV 660 670 680 690 700 710 540 550 560 570 580 590 pF1KB4 PLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYP :. :::: .:.:.:::.:..::::::.:.:::: : ::..::..:::: ::.::.: CCDS60 PIMVVRTEKNSLNNRFLPWNEIETEAILSIDDDA-HLRHDEIMFGFRVWREARDRIVGFP 720 730 740 750 760 770 600 610 620 630 640 650 pF1KB4 GRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCE :: : :: ..: :.:... :.:::::::::.:::. :::.: :: :.. :: ..::: CCDS60 GRYHAWDIPHQSWLYNSNYSCELSMVLTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCE 780 790 800 810 820 830 660 670 680 690 700 710 pF1KB4 DIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTM ::::::::...: : :::: : :.:: : ..:: :..:. :: .::: :..:.: : CCDS60 DIAMNFLVSHITRKPPIKVTSRWTFRCPGCP--QALSHDDSHFHERHKCINFFVKVYGYM 840 850 860 870 880 890 720 730 740 pF1KB4 PLKVVEHRADPVLYKDDFP-EKLKSFPNIGSL :: .. :.: ::.: .: .: : : CCDS60 PLLYTQFRVDSVLFKTRLPHDKTKCFKFI 900 910 >>CCDS271.1 EXTL1 gene_id:2134|Hs108|chr1 (676 aa) initn: 839 init1: 418 opt: 850 Z-score: 1044.5 bits: 203.8 E(32554): 7.4e-52 Smith-Waterman score: 991; 31.2% identity (58.8% similar) in 658 aa overlap (99-740:64-670) 70 80 90 100 110 120 pF1KB4 GMFQFWPHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDL--SCRMHTCFDVYRCGF :: :. : .. :: ..:::. .: CCDS27 LPPRPRPGASQGWPRWLDAELLQSFSQPGELPEDAVSPPQAPHGGSCNWESCFDTSKCR- 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB4 NPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDINRACLFVPSID . .::..: . .:::. . ..: .: : .:: . :::.. CCDS27 --GDGLKVFVYP-----------AVGTISETHRRILASIEGSRFYTFSPAGACLLL---- 100 110 120 130 190 200 210 220 230 240 pF1KB4 VLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFS .:. .. .:.. .. .:.:: :::.. . :. : . : .:..: .. . CCDS27 LLSLDA----QTGECSSMPLQWNRGRNHLVLRLHPA-PCPRTFQLG----QAMVAEASPT 140 150 160 170 180 250 260 270 280 290 300 pF1KB4 TWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGE . ..: :.::..: . : . : .: .: : : : :. : ::. ..: CCDS27 VDSFRPGFDVALP-FLPEAH----PLRGGAPGQLRQHSPQPGVA------LLALEEERGG 190 200 210 220 230 310 320 330 340 350 360 pF1KB4 SVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQ---VLQEATFCVVLRGARLGQAV-LSDV . .. . .. ::.. : .: .::::.. : : : . .. CCDS27 W-----RTADTGSSACPWDGRCEQDPGPGQTQRQETLPNATFCLI-SGHRPEAASRFLQA 240 250 260 270 280 370 380 390 400 410 420 pF1KB4 LQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQARW :::::.::... . ::::::.:: .:..:. :. .: . :: . .. ...:... CCDS27 LQAGCIPVLLSPRWELPFSEVIDWTKAAIVADERLPLQVLAALQEMSPARVLALRQQTQF 290 300 310 320 330 340 430 440 450 460 470 pF1KB4 FWEAYFQSIKAIALATLQIINDRIYPYAAISYEEWNDPP----AVKWGSVSNPLFLPLIP .:.:::.:.. . .::..:.:::. .: ::.:: :.. :.: : .:. CCDS27 LWDAYFSSVEKVIHTTLEVIQDRIFGTSAHPSLLWNSPPGALLALSTFSTS-PQDFPFYY 350 360 370 380 390 400 480 490 500 510 520 530 pF1KB4 PQSQG------FTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPK : :: :.:.. . . ...: :. ...::.:.:. : : ::. CCDS27 LQ-QGSRPEGRFSALIWVGPPGQPPLKLIQAVAGSQHCAQILVLWSNER---PLPSRWPE 410 420 430 440 450 460 540 550 560 570 580 590 pF1KB4 IRVPLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLV ::: :. .. :.:.::.::. :.:.:.:..: . :: :..:.. ::. ::.:.: CCDS27 TAVPLTVI-DGHRKVSDRFYPYSTIRTDAILSLDARSSLSTS-EVDFAFLVWQSFPERMV 470 480 490 500 510 520 600 610 620 630 640 650 pF1KB4 GYPGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHM :. :.::. . : : .: ::: ::::: :::::.:.. :.:...: ... .: CCDS27 GFLTSSHFWDEAHGGWGYTAERTNEFSMVLTTAAFYHRYYHTLFTHSLPKALRTLADEAP 530 540 550 560 570 580 660 670 680 690 700 710 pF1KB4 NCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVF .: :. :::.:: :: ::: :. . : : . . .:::..:..: CCDS27 TCVDVLMNFIVAAVTKLPPIKVPYGKQRQEAAPLAPGGPGPRPKPPAPAPDCINQIAAAF 590 600 610 620 630 640 720 730 740 pF1KB4 GTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGSL : ::: . : ::::.:: . :.. CCDS27 GHMPLLSSRLRLDPVLFKDPVSVQRKKYRSLEKP 650 660 670 >>CCDS6324.1 EXT1 gene_id:2131|Hs108|chr8 (746 aa) initn: 1311 init1: 424 opt: 735 Z-score: 901.3 bits: 177.4 E(32554): 7e-44 Smith-Waterman score: 1433; 35.7% identity (64.9% similar) in 715 aa overlap (72-746:53-746) 50 60 70 80 90 pF1KB4 LIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPH---SIESSNDWNV---EKRSIRDVP .:::. ... :. : :.. : CCDS63 FGGLQFRASRSHSRREEHSGRNGLHHPSPDHFWPRFPDALRPFVPWDQLENEDSSVHISP 30 40 50 60 70 80 100 110 120 130 140 150 pF1KB4 VVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTIS . :.: : .: .:::..::: : :: .:::.: .: .. :. CCDS63 RQKRDANSSI-YKGK-KCRMESCFDFTLC---KKNGFKVYVYPQQK---------GEKIA 90 100 110 120 160 170 180 190 200 210 pF1KB4 REYNELLMAISDSDYYTDDINRACLFVPSIDVLNQNTLR---IKETAQAMAQLSRWDRGT . :...: :: : .::.: ..::::: :.:.:... : ... . . .: :. : CCDS63 ESYQNILAAIEGSRFYTSDPSQACLFVLSLDTLDRDQLSPQYVHNLRSKVQSLHLWNNGR 130 140 150 160 170 180 220 230 240 250 260 270 pF1KB4 NHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPE :::.::. : :::. . .:.:: ...:: ..: ..:::::..: .. : CCDS63 NHLIFNLYSGTWPDYTEDVGFDIGQAMLAKASISTENFRPNFDVSIPLFSKDHPRTG-GE 190 200 210 220 230 240 280 290 300 310 320 pF1KB4 KG-------PGPRQYFLLSSQ----VGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGV .: : :.:.:. . .:. . :. : .:..::.:..: : . .. CCDS63 RGFLKFNTIPPLRKYMLVFKGKRYLTGIGSDTRNAL--YHVHNGEDVVLLTTCKHGKDWQ 250 260 270 280 290 300 330 340 350 360 370 pF1KB4 LSVRKRCHK----HQVFDYPQVLQEATFCVVLRGARLGQAVLSDVLQAGCVPVVIADSYI .:: . .. .:: ..:..::::.: :: :::. . ..:::.::::...... CCDS63 KHKDSRCDRDNTEYEKYDYREMLHNATFCLVPRGRRLGSFRFLEALQAACVPVMLSNGWE 310 320 330 340 350 360 380 390 400 410 420 430 pF1KB4 LPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQARWFWEAYFQSIKAIALA ::::::..:..:.:. :. . .. : ..:: : .: ...:....:::::.:.. :.:. CCDS63 LPFSEVINWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLT 370 380 390 400 410 420 440 450 460 470 480 pF1KB4 TLQIINDRIYPYAAISYEEWNDPPA-----VKWGSVSN--PLF---LPLIPPQSQGFTAI ::.::.:::. . . . :: :. ...: . : . : : ::.. :::. CCDS63 TLEIIQDRIFKHISRNSLIWNKHPGGLFVLPQYSSYLGDFPYYYANLGLKPPSK--FTAV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 VLTY----DRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRVPLKVVRTA . . .. . ...... ..: ....:.:: .: : :: ::. :.. CCDS63 IHAVTPLVSQSQPVLKLLVAAAKSQYCAQIIVLWNC-DKPLPAKHRWPATAVPVVVIEGE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB4 ENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDH . .:.::.:::.: :.:::..:.: . :.. :..:.. ::. ::.:.::::.: :.::. CCDS63 SKVMSSRFLPYDNIITDAVLSLDEDTV-LSTTEVDFAFTVWQSFPERIVGYPARSHFWDN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB4 EMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMNFLV ..: : :.:::. ::::::::.::::..:::.. .:...:: :: ::::: ::::: CCDS63 SKERWGYTSKWTNDYSMVLTGAAIYHKYYHYLYSHYLPASLKNMVDQLANCEDILMNFLV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB4 ANVTGKAVIKVTPRKKFKCPECTAIDGLS--LDQTHMVERSECINKFASVFGTMPLKVVE . :: :::: .:..: . : : :...:. :.: ::: :: ::: . CCDS63 SAVTKLPPIKVTQKKQYKETMMGQTSRASRWADPDHFAQRQSCMNTFASWFGYMPLIHSQ 670 680 690 700 710 720 730 740 pF1KB4 HRADPVLYKDDFPEKLKSFPNIGSL : ::::.::. :.. .: : CCDS63 MRLDPVLFKDQVSILRKKYRDIERL 730 740 >>CCDS775.1 EXTL2 gene_id:2135|Hs108|chr1 (330 aa) initn: 471 init1: 125 opt: 411 Z-score: 506.4 bits: 103.2 E(32554): 6.9e-22 Smith-Waterman score: 480; 31.9% identity (67.3% similar) in 248 aa overlap (484-718:66-310) 460 470 480 490 500 510 pF1KB4 YEEWNDPPAVKWGSVSNPLFLPLIPPQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKL :: :. ::.:.. :...... . ::.: :. CCDS77 LTALLPSVKEDKMLMLRREIKSQGKSTMDSFTLIMQTYNRTDLLLKLLNHYQAVPNLHKV 40 50 60 70 80 90 520 530 540 550 560 570 pF1KB4 LVVWNNQNKNPPEDSLWPKIR---VPLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDII .::::: ... : : :: .. .:. . . :.. ::. . :.::.::: .::: . CCDS77 IVVWNNIGEKAP-DELWNSLGPHPIPVIFKQQTANRMRNRLQVFPELETNAVLMVDDDTL 100 110 120 130 140 150 580 590 600 610 620 pF1KB4 MLTSDELQFGYEVWREFPDRLVGYPGRLHLWD----HEMNKWKYESEWT---NEVSMVLT . : : : :.. ::..:::..::. : :. . ........ . .. :::: CCDS77 ISTPD-LVFAFSVWQQFPDQIVGFVPRKHVSTSSGIYSYGSFEMQAPGSGNGDQYSMVLI 160 170 180 190 200 210 630 640 650 660 670 680 pF1KB4 GAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMNFLVANVTGKA---VIKVTPRKKF ::.:... . :. ..:. .. .: .::.::::::..:. ::. .: . .. CCDS77 GASFFNSKYLELFQ-RQPAAVHALIDDTQNCDDIAMNFIIAKHIGKTSGIFVKPVNMDNL 220 230 240 250 260 270 690 700 710 720 730 740 pF1KB4 KCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKSF . .. .:. : ..:: ::::..... .:::. CCDS77 EKETNSGYSGMWHRAEHALQRSYCINKLVNIYDSMPLRYSNIMISQFGFPYANYKRKI 280 290 300 310 320 330 pF1KB4 PNIGSL 746 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 21:39:30 2016 done: Thu Nov 3 21:39:30 2016 Total Scan time: 3.330 Total Display time: 0.130 Function used was FASTA [36.3.4 Apr, 2011]