FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4662, 394 aa 1>>>pF1KB4662 394 - 394 aa - 394 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8176+/-0.000418; mu= 19.2197+/- 0.026 mean_var=57.0272+/-11.761, 0's: 0 Z-trim(110.2): 48 B-trim: 0 in 0/50 Lambda= 0.169837 statistics sampled from 18516 (18564) to 18516 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.604), E-opt: 0.2 (0.218), width: 16 Scan time: 8.160 The best scores are: opt bits E(85289) NP_005713 (OMIM: 604221) actin-related protein 2 i ( 394) 2603 646.3 3.7e-185 NP_001005386 (OMIM: 604221) actin-related protein ( 399) 2583 641.4 1.1e-183 NP_005150 (OMIM: 102540,612098,612794,613424) acti ( 377) 1115 281.7 2e-75 NP_001092 (OMIM: 102630,243310,607371,608578) acti ( 375) 1113 281.2 2.8e-75 NP_001186883 (OMIM: 102560,604717,614583) actin, c ( 375) 1110 280.5 4.7e-75 NP_001605 (OMIM: 102560,604717,614583) actin, cyto ( 375) 1110 280.5 4.7e-75 NP_001091 (OMIM: 102610,161800,255310,616852) acti ( 377) 1110 280.5 4.7e-75 NP_001606 (OMIM: 102545) actin, gamma-enteric smoo ( 376) 1101 278.3 2.2e-74 NP_001307784 (OMIM: 102620,611788,613834,614042) a ( 377) 1101 278.3 2.2e-74 NP_001604 (OMIM: 102620,611788,613834,614042) acti ( 377) 1101 278.3 2.2e-74 NP_001135417 (OMIM: 102620,611788,613834,614042) a ( 377) 1101 278.3 2.2e-74 XP_016859649 (OMIM: 608914) PREDICTED: POTE ankyri ( 657) 1088 275.2 3.1e-73 NP_001017992 (OMIM: 614835) beta-actin-like protei ( 376) 1084 274.1 3.9e-73 XP_011509518 (OMIM: 608914) PREDICTED: POTE ankyri ( 957) 1088 275.3 4.2e-73 XP_016859648 (OMIM: 608914) PREDICTED: POTE ankyri ( 967) 1088 275.3 4.2e-73 XP_016859650 (OMIM: 608914) PREDICTED: POTE ankyri (1075) 1088 275.4 4.6e-73 NP_001077007 (OMIM: 608914) POTE ankyrin domain fa (1075) 1088 275.4 4.6e-73 NP_005726 (OMIM: 605144) beta-centractin [Homo sap ( 376) 1012 256.5 7.9e-68 NP_005727 (OMIM: 605143) alpha-centractin [Homo sa ( 376) 1001 253.8 5.1e-67 XP_016858605 (OMIM: 605144) PREDICTED: beta-centra ( 332) 901 229.2 1.1e-59 NP_001186822 (OMIM: 102545) actin, gamma-enteric s ( 333) 837 213.6 5.8e-55 NP_115876 (OMIM: 608534) actin-related protein T3 ( 372) 837 213.6 6.3e-55 XP_005263911 (OMIM: 605144) PREDICTED: beta-centra ( 302) 833 212.5 1.1e-54 NP_612146 (OMIM: 300487) actin-related protein T1 ( 376) 810 207.0 6.3e-53 NP_536356 (OMIM: 608535) actin-related protein T2 ( 377) 806 206.0 1.2e-52 NP_006678 (OMIM: 604303) actin-like protein 7A [Ho ( 435) 742 190.3 7.3e-48 NP_006677 (OMIM: 604304) actin-like protein 7B [Ho ( 415) 707 181.8 2.7e-45 NP_005712 (OMIM: 604222) actin-related protein 3 i ( 418) 592 153.6 8.2e-37 NP_001264069 (OMIM: 604222) actin-related protein ( 367) 588 152.6 1.5e-36 NP_004292 (OMIM: 604958) actin-like protein 6A iso ( 429) 300 82.0 2.9e-15 NP_057272 (OMIM: 612458) actin-like protein 6B [Ho ( 426) 295 80.8 6.7e-15 NP_829888 (OMIM: 604958) actin-like protein 6A iso ( 387) 259 72.0 2.8e-12 NP_817126 (OMIM: 604958) actin-like protein 6A iso ( 387) 259 72.0 2.8e-12 >>NP_005713 (OMIM: 604221) actin-related protein 2 isofo (394 aa) initn: 2603 init1: 2603 opt: 2603 Z-score: 3445.2 bits: 646.3 E(85289): 3.7e-185 Smith-Waterman score: 2603; 100.0% identity (100.0% similar) in 394 aa overlap (1-394:1-394) 10 20 30 40 50 60 pF1KB4 MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 ASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 EKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 RLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 VESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 IVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 IVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAV 310 320 330 340 350 360 370 380 390 pF1KB4 LADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR :::::::::::::::::::::::::::::::::: NP_005 LADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR 370 380 390 >>NP_001005386 (OMIM: 604221) actin-related protein 2 is (399 aa) initn: 2247 init1: 2247 opt: 2583 Z-score: 3418.7 bits: 641.4 E(85289): 1.1e-183 Smith-Waterman score: 2583; 98.7% identity (98.7% similar) in 399 aa overlap (1-394:1-399) 10 20 30 40 50 pF1KB4 MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIK-----DL ::::::::::::::::::::::::::::::::::::::::::::::::::::: :: NP_001 MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKNNKKMDL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 MVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMN 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 PTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB4 PHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLAL 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB4 ETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRS 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB4 EFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVF 310 320 330 340 350 360 360 370 380 390 pF1KB4 LGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR ::::::::::::::::::::::::::::::::::::::: NP_001 LGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR 370 380 390 >>NP_005150 (OMIM: 102540,612098,612794,613424) actin, a (377 aa) initn: 1187 init1: 819 opt: 1115 Z-score: 1475.1 bits: 281.7 E(85289): 2e-75 Smith-Waterman score: 1213; 46.8% identity (75.5% similar) in 387 aa overlap (2-388:3-374) 10 20 30 40 50 pF1KB4 MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGD :.. ..:::::.:.:: :.::.. :. .::..:::: : . .. :: .::: NP_005 MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRP--RHQGVMVGMGQKDSYVGD 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 EASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKN ::. :..: ..::.:.::. :::::...: .:: : : . .. :::: :.:: : NP_005 EAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNE-LRVAPEEHPTLLTEAPLNPKAN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 REKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLT :::....::::.. ..::::::::.:::.: ::.:.:::::::: :.:::..::: NP_005 REKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAI 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB4 RRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTV :::.::::.: ::.:.: :::.: .:. : :: ::::::::. ..:.:. : .. NP_005 MRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB4 LVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYK : .:: ::::..: .:.:::. ::.:::: .:..:..:. : .:.:. ::: :...: NP_005 LEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB4 HIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGA . :::::.:::::. .:...:. : : .::.: ::.::. :..::. NP_005 NNVLSGGTTMYPGIADRMQKEITAL-----------APSTMKIKIIAPPERKYSVWIGGS 300 310 320 330 340 360 370 380 390 pF1KB4 VLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR .::. .. ...:...:::.: : .... NP_005 ILAS-LSTFQQMWISKQEYDEAGPSIVHRKCF 350 360 370 >>NP_001092 (OMIM: 102630,243310,607371,608578) actin, c (375 aa) initn: 1183 init1: 835 opt: 1113 Z-score: 1472.5 bits: 281.2 E(85289): 2.8e-75 Smith-Waterman score: 1212; 47.2% identity (75.5% similar) in 388 aa overlap (1-388:1-372) 10 20 30 40 50 60 pF1KB4 MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDE ::.. .:: :::.:. : :.::.. :. .::..:::: : . .. :: .:::: NP_001 MDDDIAALVV-DNGSGMCKAGFAGDDAPRAVFPSIVGRP--RHQGVMVGMGQKDSYVGDE 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 ASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNR :. :..: ..::.:.::: :::::...: .:: : : . .. .:::: :.:: :: NP_001 AQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNE-LRVAPEEHPVLLTEAPLNPKANR 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB4 EKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTR ::....::::.. ..::::::::.:::.: ::.:.:::::::: :.:::..::: NP_001 EKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAIL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB4 RLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVL :::.::::.: ::.:.: :::.:. .:. : :: ::::::::. ..:::. : .. : NP_001 RLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB4 VESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKH .:: ::::..: .:.:::. ::::::: ....:. :. : ::.:. :.: :...: . NP_001 EKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYAN 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB4 IVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAV :::::.:::::. .:...:. : : .::.: ::.::. :..::.. NP_001 TVLSGGTTMYPGIADRMQKEITAL-----------APSTMKIKIIAPPERKYSVWIGGSI 300 310 320 330 340 370 380 390 pF1KB4 LADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR ::. .. ...:...:::.:.: .... NP_001 LAS-LSTFQQMWISKQEYDESGPSIVHRKCF 350 360 370 >>NP_001186883 (OMIM: 102560,604717,614583) actin, cytop (375 aa) initn: 1182 init1: 835 opt: 1110 Z-score: 1468.5 bits: 280.5 E(85289): 4.7e-75 Smith-Waterman score: 1209; 47.4% identity (75.8% similar) in 380 aa overlap (9-388:8-372) 10 20 30 40 50 60 pF1KB4 MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDE .: :::.:. : :.::.. :. .::..:::: : . .. :: .:::: NP_001 MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRP--RHQGVMVGMGQKDSYVGDE 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 ASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNR :. :..: ..::.:.::: :::::...: .:: : : . .. .:::: :.:: :: NP_001 AQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNE-LRVAPEEHPVLLTEAPLNPKANR 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB4 EKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTR ::....::::.. ..::::::::.:::.: ::.:.:::::::: :.:::..::: NP_001 EKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAIL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB4 RLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVL :::.::::.: ::.:.: :::.:. .:. : :: ::::::::. ..:::. : .. : NP_001 RLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB4 VESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKH .:: ::::..: .:.:::. ::::::: ....:. :. : ::.:. :.: :...: . NP_001 EKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYAN 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB4 IVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAV :::::.:::::. .:...:. : : .::.: ::.::. :..::.. NP_001 TVLSGGTTMYPGIADRMQKEITAL-----------APSTMKIKIIAPPERKYSVWIGGSI 300 310 320 330 340 370 380 390 pF1KB4 LADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR ::. .. ...:...:::.:.: .... NP_001 LAS-LSTFQQMWISKQEYDESGPSIVHRKCF 350 360 370 >>NP_001605 (OMIM: 102560,604717,614583) actin, cytoplas (375 aa) initn: 1182 init1: 835 opt: 1110 Z-score: 1468.5 bits: 280.5 E(85289): 4.7e-75 Smith-Waterman score: 1209; 47.4% identity (75.8% similar) in 380 aa overlap (9-388:8-372) 10 20 30 40 50 60 pF1KB4 MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDE .: :::.:. : :.::.. :. .::..:::: : . .. :: .:::: NP_001 MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRP--RHQGVMVGMGQKDSYVGDE 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 ASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNR :. :..: ..::.:.::: :::::...: .:: : : . .. .:::: :.:: :: NP_001 AQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNE-LRVAPEEHPVLLTEAPLNPKANR 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB4 EKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTR ::....::::.. ..::::::::.:::.: ::.:.:::::::: :.:::..::: NP_001 EKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAIL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB4 RLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVL :::.::::.: ::.:.: :::.:. .:. : :: ::::::::. ..:::. : .. : NP_001 RLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB4 VESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKH .:: ::::..: .:.:::. ::::::: ....:. :. : ::.:. :.: :...: . NP_001 EKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYAN 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB4 IVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAV :::::.:::::. .:...:. : : .::.: ::.::. :..::.. NP_001 TVLSGGTTMYPGIADRMQKEITAL-----------APSTMKIKIIAPPERKYSVWIGGSI 300 310 320 330 340 370 380 390 pF1KB4 LADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR ::. .. ...:...:::.:.: .... NP_001 LAS-LSTFQQMWISKQEYDESGPSIVHRKCF 350 360 370 >>NP_001091 (OMIM: 102610,161800,255310,616852) actin, a (377 aa) initn: 1185 init1: 817 opt: 1110 Z-score: 1468.5 bits: 280.5 E(85289): 4.7e-75 Smith-Waterman score: 1211; 46.8% identity (75.2% similar) in 387 aa overlap (2-388:3-374) 10 20 30 40 50 pF1KB4 MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGD : . ..:::::.:.:: :.::.. :. .::..:::: : . .. :: .::: NP_001 MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRP--RHQGVMVGMGQKDSYVGD 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 EASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKN ::. :..: ..::.:.::. :::::...: .:: : : . .. :::: :.:: : NP_001 EAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNE-LRVAPEEHPTLLTEAPLNPKAN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 REKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLT :::....::::.. ..::::::::.:::.: ::.:.:::::::: :.:::..::: NP_001 REKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAI 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB4 RRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTV :::.::::.: ::.:.: :::.: .:. : :: ::::::::. ..:.:. : .. NP_001 MRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB4 LVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYK : .:: ::::..: .:.:::. ::.:::: .:..:..:. : .:.:. ::: :...: NP_001 LEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB4 HIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGA . :.:::.:::::. .:...:. : : .::.: ::.::. :..::. NP_001 NNVMSGGTTMYPGIADRMQKEITAL-----------APSTMKIKIIAPPERKYSVWIGGS 300 310 320 330 340 360 370 380 390 pF1KB4 VLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR .::. .. ...:.:.:::.: : .... NP_001 ILAS-LSTFQQMWITKQEYDEAGPSIVHRKCF 350 360 370 >>NP_001606 (OMIM: 102545) actin, gamma-enteric smooth m (376 aa) initn: 1178 init1: 819 opt: 1101 Z-score: 1456.6 bits: 278.3 E(85289): 2.2e-74 Smith-Waterman score: 1191; 46.6% identity (75.3% similar) in 380 aa overlap (9-388:9-373) 10 20 30 40 50 60 pF1KB4 MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDE .:::::.:. : :.::.. :. .::..:::: : . .. :: .:::: NP_001 MCEEETTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRP--RHQGVMVGMGQKDSYVGDE 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 ASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNR :. :..: ..::.:.::. :::::...: ..: : : . .. :::: :.:: :: NP_001 AQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNE-LRVAPEEHPTLLTEAPLNPKANR 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB4 EKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTR ::....::::.. ..::::::::.:::.: ::.:.:::::::: :.:::..::: NP_001 EKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIM 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB4 RLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVL :::.::::.: ::.:.: :::.: .:. : :: ::::::::. ..:.:. : .. : NP_001 RLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB4 VESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKH .:: ::::..: .:.:::. ::.:::: .:..:..:. : .:.:. ::: :...: . NP_001 EKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYAN 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB4 IVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAV :::::.:::::. .:...:. : : .::.: ::.::. :..::.. NP_001 NVLSGGTTMYPGIADRMQKEITAL-----------APSTMKIKIIAPPERKYSVWIGGSI 300 310 320 330 340 370 380 390 pF1KB4 LADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR ::. .. ...:... ::.: : .... NP_001 LAS-LSTFQQMWISKPEYDEAGPSIVHRKCF 350 360 370 >>NP_001307784 (OMIM: 102620,611788,613834,614042) actin (377 aa) initn: 1178 init1: 819 opt: 1101 Z-score: 1456.6 bits: 278.3 E(85289): 2.2e-74 Smith-Waterman score: 1199; 46.8% identity (75.5% similar) in 380 aa overlap (9-388:10-374) 10 20 30 40 50 pF1KB4 MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGD .:::::.:. : :.::.. :. .::..:::: : . .. :: .::: NP_001 MCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRP--RHQGVMVGMGQKDSYVGD 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 EASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKN ::. :..: ..::.:.::. :::::...: ..: : : . .. :::: :.:: : NP_001 EAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNE-LRVAPEEHPTLLTEAPLNPKAN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 REKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLT :::....::::.. ..::::::::.:::.: ::.:.:::::::: :.:::..::: NP_001 REKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAI 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB4 RRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTV :::.::::.: ::.:.: :::.: .:. : :: ::::::::. ..:.:. : .. NP_001 MRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB4 LVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYK : .:: ::::..: .:.:::. ::.:::: .:..:..:. : .:.:. ::: :...: NP_001 LEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB4 HIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGA . :::::.:::::. .:...:. : : .::.: ::.::. :..::. NP_001 NNVLSGGTTMYPGIADRMQKEITAL-----------APSTMKIKIIAPPERKYSVWIGGS 300 310 320 330 340 360 370 380 390 pF1KB4 VLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR .::. .. ...:...:::.: : .... NP_001 ILAS-LSTFQQMWISKQEYDEAGPSIVHRKCF 350 360 370 >>NP_001604 (OMIM: 102620,611788,613834,614042) actin, a (377 aa) initn: 1178 init1: 819 opt: 1101 Z-score: 1456.6 bits: 278.3 E(85289): 2.2e-74 Smith-Waterman score: 1199; 46.8% identity (75.5% similar) in 380 aa overlap (9-388:10-374) 10 20 30 40 50 pF1KB4 MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGD .:::::.:. : :.::.. :. .::..:::: : . .. :: .::: NP_001 MCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRP--RHQGVMVGMGQKDSYVGD 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 EASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKN ::. :..: ..::.:.::. :::::...: ..: : : . .. :::: :.:: : NP_001 EAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNE-LRVAPEEHPTLLTEAPLNPKAN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 REKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLT :::....::::.. ..::::::::.:::.: ::.:.:::::::: :.:::..::: NP_001 REKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAI 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB4 RRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTV :::.::::.: ::.:.: :::.: .:. : :: ::::::::. ..:.:. : .. NP_001 MRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB4 LVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYK : .:: ::::..: .:.:::. ::.:::: .:..:..:. : .:.:. ::: :...: NP_001 LEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB4 HIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGA . :::::.:::::. .:...:. : : .::.: ::.::. :..::. NP_001 NNVLSGGTTMYPGIADRMQKEITAL-----------APSTMKIKIIAPPERKYSVWIGGS 300 310 320 330 340 360 370 380 390 pF1KB4 VLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR .::. .. ...:...:::.: : .... NP_001 ILAS-LSTFQQMWISKQEYDEAGPSIVHRKCF 350 360 370 394 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 03:07:48 2016 done: Fri Nov 4 03:07:50 2016 Total Scan time: 8.160 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]