FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4670, 401 aa 1>>>pF1KB4670 401 - 401 aa - 401 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.1480+/-0.000323; mu= 9.9448+/- 0.020 mean_var=145.4537+/-29.165, 0's: 0 Z-trim(120.5): 121 B-trim: 0 in 0/54 Lambda= 0.106344 statistics sampled from 35684 (35810) to 35684 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.762), E-opt: 0.2 (0.42), width: 16 Scan time: 8.710 The best scores are: opt bits E(85289) NP_733777 (OMIM: 601740) homeobox protein Meis2 is ( 401) 2817 443.5 4.4e-124 XP_006720587 (OMIM: 601740) PREDICTED: homeobox pr ( 400) 2791 439.5 6.9e-123 NP_733774 (OMIM: 601740) homeobox protein Meis2 is ( 394) 2744 432.3 1e-120 NP_758526 (OMIM: 601740) homeobox protein Meis2 is ( 388) 2720 428.6 1.3e-119 XP_006720588 (OMIM: 601740) PREDICTED: homeobox pr ( 393) 2718 428.3 1.6e-119 NP_733775 (OMIM: 601740) homeobox protein Meis2 is ( 477) 2679 422.4 1.2e-117 XP_006720586 (OMIM: 601740) PREDICTED: homeobox pr ( 476) 2653 418.4 1.9e-116 NP_002390 (OMIM: 601740) homeobox protein Meis2 is ( 381) 2647 417.4 3e-116 NP_001207411 (OMIM: 601740) homeobox protein Meis2 ( 470) 2606 411.2 2.7e-114 NP_733776 (OMIM: 601740) homeobox protein Meis2 is ( 470) 2606 411.2 2.7e-114 XP_016859631 (OMIM: 601739) PREDICTED: homeobox pr ( 417) 2101 333.6 5.3e-91 XP_005264379 (OMIM: 601739) PREDICTED: homeobox pr ( 465) 2093 332.4 1.3e-90 XP_016877694 (OMIM: 601740) PREDICTED: homeobox pr ( 306) 2090 331.8 1.3e-90 NP_758527 (OMIM: 601740) homeobox protein Meis2 is ( 306) 2090 331.8 1.3e-90 XP_016859630 (OMIM: 601739) PREDICTED: homeobox pr ( 433) 2075 329.7 8.6e-90 NP_002389 (OMIM: 601739) homeobox protein Meis1 [H ( 390) 2074 329.5 8.8e-90 XP_005264378 (OMIM: 601739) PREDICTED: homeobox pr ( 481) 2067 328.5 2.2e-89 XP_005264380 (OMIM: 601739) PREDICTED: homeobox pr ( 406) 2048 325.5 1.4e-88 XP_006720589 (OMIM: 601740) PREDICTED: homeobox pr ( 389) 2025 321.9 1.6e-87 XP_006720592 (OMIM: 601740) PREDICTED: homeobox pr ( 255) 1777 283.8 3.3e-76 XP_016859632 (OMIM: 601739) PREDICTED: homeobox pr ( 352) 1653 264.8 2.3e-70 XP_005264381 (OMIM: 601739) PREDICTED: homeobox pr ( 400) 1645 263.7 5.8e-70 XP_011519893 (OMIM: 601740) PREDICTED: homeobox pr ( 331) 1639 262.7 9.6e-70 XP_006720590 (OMIM: 601740) PREDICTED: homeobox pr ( 331) 1639 262.7 9.6e-70 XP_005264382 (OMIM: 601739) PREDICTED: homeobox pr ( 325) 1626 260.7 3.8e-69 XP_016859635 (OMIM: 601739) PREDICTED: homeobox pr ( 246) 1477 237.7 2.3e-62 XP_016859634 (OMIM: 601739) PREDICTED: homeobox pr ( 321) 1344 217.4 3.9e-56 XP_016859633 (OMIM: 601739) PREDICTED: homeobox pr ( 321) 1344 217.4 3.9e-56 XP_011541248 (OMIM: 613066) PREDICTED: homeobox pr ( 356) 451 80.4 7.5e-15 XP_016873601 (OMIM: 613066) PREDICTED: homeobox pr ( 327) 440 78.7 2.3e-14 NP_004562 (OMIM: 602100) homeobox protein PKNOX1 i ( 436) 436 78.2 4.3e-14 NP_001307623 (OMIM: 602100) homeobox protein PKNOX ( 435) 432 77.6 6.6e-14 XP_006718957 (OMIM: 613066) PREDICTED: homeobox pr ( 339) 380 69.5 1.4e-11 XP_016873600 (OMIM: 613066) PREDICTED: homeobox pr ( 339) 380 69.5 1.4e-11 XP_011541249 (OMIM: 613066) PREDICTED: homeobox pr ( 339) 380 69.5 1.4e-11 XP_005271700 (OMIM: 613066) PREDICTED: homeobox pr ( 443) 380 69.6 1.7e-11 NP_071345 (OMIM: 613066) homeobox protein PKNOX2 [ ( 472) 380 69.6 1.8e-11 XP_011541247 (OMIM: 613066) PREDICTED: homeobox pr ( 472) 380 69.6 1.8e-11 XP_005271699 (OMIM: 613066) PREDICTED: homeobox pr ( 472) 380 69.6 1.8e-11 XP_011541246 (OMIM: 613066) PREDICTED: homeobox pr ( 472) 380 69.6 1.8e-11 XP_016873599 (OMIM: 613066) PREDICTED: homeobox pr ( 472) 380 69.6 1.8e-11 NP_001273187 (OMIM: 602100) homeobox protein PKNOX ( 319) 355 65.7 1.9e-10 NP_620410 (OMIM: 300411) homeobox protein TGIF2LX ( 241) 266 51.9 1.9e-06 NP_631960 (OMIM: 400025) homeobox protein TGIF2LY ( 185) 257 50.4 4.1e-06 NP_775299 (OMIM: 142946,602630) homeobox protein T ( 286) 244 48.6 2.3e-05 NP_001186444 (OMIM: 607294) homeobox protein TGIF2 ( 237) 242 48.2 2.5e-05 NP_068581 (OMIM: 607294) homeobox protein TGIF2 [H ( 237) 242 48.2 2.5e-05 NP_001186442 (OMIM: 607294) homeobox protein TGIF2 ( 237) 242 48.2 2.5e-05 NP_001186443 (OMIM: 607294) homeobox protein TGIF2 ( 237) 242 48.2 2.5e-05 NP_733796 (OMIM: 142946,602630) homeobox protein T ( 401) 241 48.3 4.1e-05 >>NP_733777 (OMIM: 601740) homeobox protein Meis2 isofor (401 aa) initn: 2817 init1: 2817 opt: 2817 Z-score: 2348.7 bits: 443.5 E(85289): 4.4e-124 Smith-Waterman score: 2817; 100.0% identity (100.0% similar) in 401 aa overlap (1-401:1-401) 10 20 30 40 50 60 pF1KB4 MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS 310 320 330 340 350 360 370 380 390 400 pF1KB4 PEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWHYM ::::::::::::::::::::::::::::::::::::::::: NP_733 PEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWHYM 370 380 390 400 >>XP_006720587 (OMIM: 601740) PREDICTED: homeobox protei (400 aa) initn: 2791 init1: 2791 opt: 2791 Z-score: 2327.2 bits: 439.5 E(85289): 6.9e-123 Smith-Waterman score: 2791; 100.0% identity (100.0% similar) in 397 aa overlap (5-401:4-400) 10 20 30 40 50 60 pF1KB4 MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MFLYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB4 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB4 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB4 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB4 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS 300 310 320 330 340 350 370 380 390 400 pF1KB4 PEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWHYM ::::::::::::::::::::::::::::::::::::::::: XP_006 PEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWHYM 360 370 380 390 400 >>NP_733774 (OMIM: 601740) homeobox protein Meis2 isofor (394 aa) initn: 2407 init1: 2407 opt: 2744 Z-score: 2288.3 bits: 432.3 E(85289): 1e-120 Smith-Waterman score: 2744; 98.3% identity (98.3% similar) in 401 aa overlap (1-401:1-394) 10 20 30 40 50 60 pF1KB4 MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS ::::::::::::::::::::::::::::::::::::::::::::: :::::::: NP_733 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRA-------VSQGAAYS 310 320 330 340 350 370 380 390 400 pF1KB4 PEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWHYM ::::::::::::::::::::::::::::::::::::::::: NP_733 PEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWHYM 360 370 380 390 >>NP_758526 (OMIM: 601740) homeobox protein Meis2 isofor (388 aa) initn: 2720 init1: 2720 opt: 2720 Z-score: 2268.5 bits: 428.6 E(85289): 1.3e-119 Smith-Waterman score: 2720; 100.0% identity (100.0% similar) in 388 aa overlap (14-401:1-388) 10 20 30 40 50 60 pF1KB4 MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV ::::::::::::::::::::::::::::::::::::::::::::::: NP_758 MDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV 10 20 30 40 70 80 90 100 110 120 pF1KB4 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_758 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB4 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_758 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB4 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_758 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB4 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_758 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB4 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_758 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS 290 300 310 320 330 340 370 380 390 400 pF1KB4 PEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWHYM ::::::::::::::::::::::::::::::::::::::::: NP_758 PEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWHYM 350 360 370 380 >>XP_006720588 (OMIM: 601740) PREDICTED: homeobox protei (393 aa) initn: 2381 init1: 2381 opt: 2718 Z-score: 2266.8 bits: 428.3 E(85289): 1.6e-119 Smith-Waterman score: 2718; 98.2% identity (98.2% similar) in 397 aa overlap (5-401:4-393) 10 20 30 40 50 60 pF1KB4 MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MFLYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB4 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB4 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB4 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB4 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS ::::::::::::::::::::::::::::::::::::::::::::: :::::::: XP_006 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRA-------VSQGAAYS 300 310 320 330 340 350 370 380 390 400 pF1KB4 PEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWHYM ::::::::::::::::::::::::::::::::::::::::: XP_006 PEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWHYM 360 370 380 390 >>NP_733775 (OMIM: 601740) homeobox protein Meis2 isofor (477 aa) initn: 2704 init1: 2674 opt: 2679 Z-score: 2233.3 bits: 422.4 E(85289): 1.2e-117 Smith-Waterman score: 2679; 97.2% identity (97.5% similar) in 400 aa overlap (1-394:1-400) 10 20 30 40 50 60 pF1KB4 MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS 310 320 330 340 350 360 370 380 390 400 pF1KB4 PEGQPMGSFVLDGQQHMGIRPAG--PMSG----MGMNMGMDGQWHYM ::::::::::::::::::::::: : : .: ::: NP_733 PEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMSMAQPSYTPPQMTPHPTQLR 370 380 390 400 410 420 NP_733 HGPPMHSYLPSHPHHPAMMMHGGPPTHPGMTMSAQSPTMLNSVDPNVGGQVMDIHAQ 430 440 450 460 470 >>XP_006720586 (OMIM: 601740) PREDICTED: homeobox protei (476 aa) initn: 2678 init1: 2648 opt: 2653 Z-score: 2211.7 bits: 418.4 E(85289): 1.9e-116 Smith-Waterman score: 2653; 97.2% identity (97.5% similar) in 396 aa overlap (5-394:4-399) 10 20 30 40 50 60 pF1KB4 MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MFLYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB4 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB4 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB4 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB4 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS 300 310 320 330 340 350 370 380 390 400 pF1KB4 PEGQPMGSFVLDGQQHMGIRPAG--PMSG----MGMNMGMDGQWHYM ::::::::::::::::::::::: : : .: ::: XP_006 PEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMSMAQPSYTPPQMTPHPTQLR 360 370 380 390 400 410 XP_006 HGPPMHSYLPSHPHHPAMMMHGGPPTHPGMTMSAQSPTMLNSVDPNVGGQVMDIHAQ 420 430 440 450 460 470 >>NP_002390 (OMIM: 601740) homeobox protein Meis2 isofor (381 aa) initn: 2310 init1: 2310 opt: 2647 Z-score: 2208.1 bits: 417.4 E(85289): 3e-116 Smith-Waterman score: 2647; 98.2% identity (98.2% similar) in 388 aa overlap (14-401:1-381) 10 20 30 40 50 60 pF1KB4 MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV ::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV 10 20 30 40 70 80 90 100 110 120 pF1KB4 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB4 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB4 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB4 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB4 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS ::::::::::::::::::::::::::::::::::::::::::::: :::::::: NP_002 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRA-------VSQGAAYS 290 300 310 320 330 340 370 380 390 400 pF1KB4 PEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWHYM ::::::::::::::::::::::::::::::::::::::::: NP_002 PEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWHYM 350 360 370 380 >>NP_001207411 (OMIM: 601740) homeobox protein Meis2 iso (470 aa) initn: 2611 init1: 2407 opt: 2606 Z-score: 2172.8 bits: 411.2 E(85289): 2.7e-114 Smith-Waterman score: 2606; 95.5% identity (95.8% similar) in 400 aa overlap (1-394:1-393) 10 20 30 40 50 60 pF1KB4 MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS ::::::::::::::::::::::::::::::::::::::::::::: :::::::: NP_001 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRA-------VSQGAAYS 310 320 330 340 350 370 380 390 400 pF1KB4 PEGQPMGSFVLDGQQHMGIRPAG--PMSG----MGMNMGMDGQWHYM ::::::::::::::::::::::: : : .: ::: NP_001 PEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMSMAQPSYTPPQMTPHPTQLR 360 370 380 390 400 410 NP_001 HGPPMHSYLPSHPHHPAMMMHGGPPTHPGMTMSAQSPTMLNSVDPNVGGQVMDIHAQ 420 430 440 450 460 470 >>NP_733776 (OMIM: 601740) homeobox protein Meis2 isofor (470 aa) initn: 2611 init1: 2407 opt: 2606 Z-score: 2172.8 bits: 411.2 E(85289): 2.7e-114 Smith-Waterman score: 2606; 95.5% identity (95.8% similar) in 400 aa overlap (1-394:1-393) 10 20 30 40 50 60 pF1KB4 MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 MPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 EDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 GKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 ASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYS ::::::::::::::::::::::::::::::::::::::::::::: :::::::: NP_733 HPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRA-------VSQGAAYS 310 320 330 340 350 370 380 390 400 pF1KB4 PEGQPMGSFVLDGQQHMGIRPAG--PMSG----MGMNMGMDGQWHYM ::::::::::::::::::::::: : : .: ::: NP_733 PEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMSMAQPSYTPPQMTPHPTQLR 360 370 380 390 400 410 NP_733 HGPPMHSYLPSHPHHPAMMMHGGPPTHPGMTMSAQSPTMLNSVDPNVGGQVMDIHAQ 420 430 440 450 460 470 401 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 15:19:15 2016 done: Thu Nov 3 15:19:16 2016 Total Scan time: 8.710 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]