FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4679, 201 aa 1>>>pF1KB4679 201 - 201 aa - 201 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0679+/-0.00033; mu= 13.6237+/- 0.021 mean_var=243.2416+/-55.269, 0's: 0 Z-trim(121.2): 76 B-trim: 2184 in 1/55 Lambda= 0.082235 statistics sampled from 37285 (37410) to 37285 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.778), E-opt: 0.2 (0.439), width: 16 Scan time: 6.390 The best scores are: opt bits E(85289) NP_001071634 (OMIM: 600812) serine/arginine-rich s ( 201) 1431 181.7 7.1e-46 NP_008855 (OMIM: 600812) serine/arginine-rich spli ( 248) 1307 167.1 2.1e-41 NP_003760 (OMIM: 601943) serine/arginine-rich spli ( 221) 865 114.6 1.2e-25 XP_011540253 (OMIM: 601940) PREDICTED: serine/argi ( 464) 464 67.5 3.7e-11 NP_005617 (OMIM: 601940) serine/arginine-rich spli ( 494) 464 67.6 3.8e-11 XP_005268056 (OMIM: 600914) PREDICTED: serine/argi ( 271) 456 66.2 5.5e-11 XP_005268057 (OMIM: 600914) PREDICTED: serine/argi ( 271) 456 66.2 5.5e-11 XP_016877082 (OMIM: 600914) PREDICTED: serine/argi ( 271) 456 66.2 5.5e-11 NP_001034554 (OMIM: 600914) serine/arginine-rich s ( 272) 456 66.2 5.5e-11 NP_008856 (OMIM: 600914) serine/arginine-rich spli ( 272) 456 66.2 5.5e-11 NP_001307143 (OMIM: 600914) serine/arginine-rich s ( 272) 456 66.2 5.5e-11 NP_006266 (OMIM: 601944) serine/arginine-rich spli ( 344) 449 65.5 1.1e-10 NP_003008 (OMIM: 603364) serine/arginine-rich spli ( 164) 257 42.2 0.00054 >>NP_001071634 (OMIM: 600812) serine/arginine-rich splic (201 aa) initn: 1431 init1: 1431 opt: 1431 Z-score: 944.6 bits: 181.7 E(85289): 7.1e-46 Smith-Waterman score: 1431; 100.0% identity (100.0% similar) in 201 aa overlap (1-201:1-201) 10 20 30 40 50 60 pF1KB4 MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 FEDPRDAEDAVYGRDGYDYDGYRLRVEFPRSGRGTGRGGGGGGGGGAPRGRYGPPSRRSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FEDPRDAEDAVYGRDGYDYDGYRLRVEFPRSGRGTGRGGGGGGGGGAPRGRYGPPSRRSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 NRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRDGTGVVEFVRKEDMTYAVRKLDNTKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRDGTGVVEFVRKEDMTYAVRKLDNTKF 130 140 150 160 170 180 190 200 pF1KB4 RSHEVGYTRILFFDQNWIQWS ::::::::::::::::::::: NP_001 RSHEVGYTRILFFDQNWIQWS 190 200 >>NP_008855 (OMIM: 600812) serine/arginine-rich splicing (248 aa) initn: 1303 init1: 1303 opt: 1307 Z-score: 864.3 bits: 167.1 E(85289): 2.1e-41 Smith-Waterman score: 1307; 96.9% identity (98.4% similar) in 192 aa overlap (1-190:1-192) 10 20 30 40 50 60 pF1KB4 MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 FEDPRDAEDAVYGRDGYDYDGYRLRVEFPRSGRGTGRGGGGGGGGGAPRGRYGPPSRRSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 FEDPRDAEDAVYGRDGYDYDGYRLRVEFPRSGRGTGRGGGGGGGGGAPRGRYGPPSRRSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 NRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRDGTGVVEFVRKEDMTYAVRKLDNTKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 NRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRDGTGVVEFVRKEDMTYAVRKLDNTKF 130 140 150 160 170 180 190 200 pF1KB4 RSHE--VGYTRILFFDQNWIQWS :::: ..: :. NP_008 RSHEGETAYIRVKVDGPRSPSYGRSRSRSRSRSRSRSRSNSRSRSYSPRRSRGSPRYSPR 190 200 210 220 230 240 >>NP_003760 (OMIM: 601943) serine/arginine-rich splicing (221 aa) initn: 507 init1: 462 opt: 865 Z-score: 581.3 bits: 114.6 E(85289): 1.2e-25 Smith-Waterman score: 875; 68.9% identity (82.4% similar) in 193 aa overlap (1-190:1-182) 10 20 30 40 50 60 pF1KB4 MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVE ::: . :: :..: :::::::: :.: ::.::.::::: ::.:.::::.: :::::. NP_003 MSGWADERG--GEGDGRIYVGNLPTDVREKDLEDLFYKYGRIREIELKNRHGLVPFAFVR 10 20 30 40 50 70 80 90 100 110 pF1KB4 FEDPRDAEDAVYGRDGYDYDGYRLRVEFPRSGRGTGRGGGGGGGGGAPRG-RYGPPSRRS ::::::::::.:::.:::: ::::::::. :: :: ::: : :::.::: NP_003 FEDPRDAEDAIYGRNGYDYGQCRLRVEFPRTY---------GGRGGWPRGGRNGPPTRRS 60 70 80 90 100 120 130 140 150 160 170 pF1KB4 ENRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRDGTGVVEFVRKEDMTYAVRKLDNTK . ::.:::::::::::::::::::::::::::: .::.:.::..::::: ::.::::.:: NP_003 DFRVLVSGLPPSGSWQDLKDHMREAGDVCYADVQKDGVGMVEYLRKEDMEYALRKLDDTK 110 120 130 140 150 160 180 190 200 pF1KB4 FRSHE--VGYTRILFFDQNWIQWS ::::: ..: :. NP_003 FRSHEGETSYIRVYPERSTSYGYSRSRSGSRGRDSPYQSRGSPHYFSPFRPY 170 180 190 200 210 220 >>XP_011540253 (OMIM: 601940) PREDICTED: serine/arginine (464 aa) initn: 443 init1: 143 opt: 464 Z-score: 321.3 bits: 67.5 E(85289): 3.7e-11 Smith-Waterman score: 464; 45.4% identity (66.1% similar) in 174 aa overlap (17-185:3-170) 10 20 30 40 50 60 pF1KB4 MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVE :.:.: : . : .:.: : :: : ..:::: : ::: XP_011 MPRVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYG-----FVE 10 20 30 40 70 80 90 100 110 pF1KB4 FEDPRDAEDAVYGRDGYDYDGYRLRVEFPRSGRGTGRGGGGGGGGG---APRGRYGPPSR :.: :::.:::: .: : : :. :: :. : : :.: .: : . : .::::.: XP_011 FDDLRDADDAVYELNGKDLCGERVIVEHARGPRRDGSYGSGRSGYGYRRSGRDKYGPPTR 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB4 RSENRVVVSGLPPSGSWQDLKDHMREAGDVCYADVY--RDGTGVVEFVRKEDMTYAVRKL .: :..: .: :::::::.::.::.: :::.. : . ::.::: :: :..:: XP_011 -TEYRLIVENLSSRCSWQDLKDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKL 110 120 130 140 150 160 180 190 200 pF1KB4 DNTKFRSHEVGYTRILFFDQNWIQWS :.:. .... XP_011 DGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSGSRSRSKSRSRSQSRSRSKKEKSRSP 170 180 190 200 210 220 >>NP_005617 (OMIM: 601940) serine/arginine-rich splicing (494 aa) initn: 443 init1: 143 opt: 464 Z-score: 321.1 bits: 67.6 E(85289): 3.8e-11 Smith-Waterman score: 464; 45.4% identity (66.1% similar) in 174 aa overlap (17-185:3-170) 10 20 30 40 50 60 pF1KB4 MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVE :.:.: : . : .:.: : :: : ..:::: : ::: NP_005 MPRVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYG-----FVE 10 20 30 40 70 80 90 100 110 pF1KB4 FEDPRDAEDAVYGRDGYDYDGYRLRVEFPRSGRGTGRGGGGGGGGG---APRGRYGPPSR :.: :::.:::: .: : : :. :: :. : : :.: .: : . : .::::.: NP_005 FDDLRDADDAVYELNGKDLCGERVIVEHARGPRRDGSYGSGRSGYGYRRSGRDKYGPPTR 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB4 RSENRVVVSGLPPSGSWQDLKDHMREAGDVCYADVY--RDGTGVVEFVRKEDMTYAVRKL .: :..: .: :::::::.::.::.: :::.. : . ::.::: :: :..:: NP_005 -TEYRLIVENLSSRCSWQDLKDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKL 110 120 130 140 150 160 180 190 200 pF1KB4 DNTKFRSHEVGYTRILFFDQNWIQWS :.:. .... NP_005 DGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRS 170 180 190 200 210 220 >>XP_005268056 (OMIM: 600914) PREDICTED: serine/arginine (271 aa) initn: 474 init1: 175 opt: 456 Z-score: 318.3 bits: 66.2 E(85289): 5.5e-11 Smith-Waterman score: 456; 45.8% identity (67.8% similar) in 177 aa overlap (16-185:4-174) 10 20 30 40 50 60 pF1KB4 MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVE ::...: : : : ::.: : :: ::::::: :: :.::: XP_005 MSGCRVFIGRLNPAAREKDVERFFKGYGRIRDIDLK--RG---FGFVE 10 20 30 40 70 80 90 100 110 pF1KB4 FEDPRDAEDAVYGRDGYDYDGYRLRVEFPRS-GRGTGRGGGGGG---GGGAPRG-RYGPP :::::::.:::: :: . . :. .: :. .:: ::: : . .. ::. : . : XP_005 FEDPRDADDAVYELDGKELCSERVTIEHARARSRG-GRGRGRYSDRFSSRRPRNDRRNAP 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB4 SRRSENRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRD--GTGVVEFVRKEDMTYAVR :.:::..: .: ::::::: ::.::.: .::..: . :::::. :. :.. XP_005 PVRTENRLIVENLSSRVSWQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIE 110 120 130 140 150 160 180 190 200 pF1KB4 KLDNTKFRSHEVGYTRILFFDQNWIQWS ::.. .. .... XP_005 KLSGKEINGRKIKLIEGSKRHRSRSRSRSRTRSSSRSRSRSRSRSRKSYSRSRSRSRSRS 170 180 190 200 210 220 >>XP_005268057 (OMIM: 600914) PREDICTED: serine/arginine (271 aa) initn: 474 init1: 175 opt: 456 Z-score: 318.3 bits: 66.2 E(85289): 5.5e-11 Smith-Waterman score: 456; 45.8% identity (67.8% similar) in 177 aa overlap (16-185:4-174) 10 20 30 40 50 60 pF1KB4 MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVE ::...: : : : ::.: : :: ::::::: :: :.::: XP_005 MSGCRVFIGRLNPAAREKDVERFFKGYGRIRDIDLK--RG---FGFVE 10 20 30 40 70 80 90 100 110 pF1KB4 FEDPRDAEDAVYGRDGYDYDGYRLRVEFPRS-GRGTGRGGGGGG---GGGAPRG-RYGPP :::::::.:::: :: . . :. .: :. .:: ::: : . .. ::. : . : XP_005 FEDPRDADDAVYELDGKELCSERVTIEHARARSRG-GRGRGRYSDRFSSRRPRNDRRNAP 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB4 SRRSENRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRD--GTGVVEFVRKEDMTYAVR :.:::..: .: ::::::: ::.::.: .::..: . :::::. :. :.. XP_005 PVRTENRLIVENLSSRVSWQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIE 110 120 130 140 150 160 180 190 200 pF1KB4 KLDNTKFRSHEVGYTRILFFDQNWIQWS ::.. .. .... XP_005 KLSGKEINGRKIKLIEGSKRHRSRSRSRSRTRSSSRSRSRSRSRSRKSYSRSRSRSRSRS 170 180 190 200 210 220 >>XP_016877082 (OMIM: 600914) PREDICTED: serine/arginine (271 aa) initn: 474 init1: 175 opt: 456 Z-score: 318.3 bits: 66.2 E(85289): 5.5e-11 Smith-Waterman score: 456; 45.8% identity (67.8% similar) in 177 aa overlap (16-185:4-174) 10 20 30 40 50 60 pF1KB4 MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVE ::...: : : : ::.: : :: ::::::: :: :.::: XP_016 MSGCRVFIGRLNPAAREKDVERFFKGYGRIRDIDLK--RG---FGFVE 10 20 30 40 70 80 90 100 110 pF1KB4 FEDPRDAEDAVYGRDGYDYDGYRLRVEFPRS-GRGTGRGGGGGG---GGGAPRG-RYGPP :::::::.:::: :: . . :. .: :. .:: ::: : . .. ::. : . : XP_016 FEDPRDADDAVYELDGKELCSERVTIEHARARSRG-GRGRGRYSDRFSSRRPRNDRRNAP 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB4 SRRSENRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRD--GTGVVEFVRKEDMTYAVR :.:::..: .: ::::::: ::.::.: .::..: . :::::. :. :.. XP_016 PVRTENRLIVENLSSRVSWQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIE 110 120 130 140 150 160 180 190 200 pF1KB4 KLDNTKFRSHEVGYTRILFFDQNWIQWS ::.. .. .... XP_016 KLSGKEINGRKIKLIEGSKRHRSRSRSRSRTRSSSRSRSRSRSRSRKSYSRSRSRSRSRS 170 180 190 200 210 220 >>NP_001034554 (OMIM: 600914) serine/arginine-rich splic (272 aa) initn: 474 init1: 175 opt: 456 Z-score: 318.3 bits: 66.2 E(85289): 5.5e-11 Smith-Waterman score: 456; 45.8% identity (67.8% similar) in 177 aa overlap (16-185:4-174) 10 20 30 40 50 60 pF1KB4 MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVE ::...: : : : ::.: : :: ::::::: :: :.::: NP_001 MSGCRVFIGRLNPAAREKDVERFFKGYGRIRDIDLK--RG---FGFVE 10 20 30 40 70 80 90 100 110 pF1KB4 FEDPRDAEDAVYGRDGYDYDGYRLRVEFPRS-GRGTGRGGGGGG---GGGAPRG-RYGPP :::::::.:::: :: . . :. .: :. .:: ::: : . .. ::. : . : NP_001 FEDPRDADDAVYELDGKELCSERVTIEHARARSRG-GRGRGRYSDRFSSRRPRNDRRNAP 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB4 SRRSENRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRD--GTGVVEFVRKEDMTYAVR :.:::..: .: ::::::: ::.::.: .::..: . :::::. :. :.. NP_001 PVRTENRLIVENLSSRVSWQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIE 110 120 130 140 150 160 180 190 200 pF1KB4 KLDNTKFRSHEVGYTRILFFDQNWIQWS ::.. .. .... NP_001 KLSGKEINGRKIKLIEGSKRHSRSRSRSRSRTRSSSRSRSRSRSRSRKSYSRSRSRSRSR 170 180 190 200 210 220 >>NP_008856 (OMIM: 600914) serine/arginine-rich splicing (272 aa) initn: 474 init1: 175 opt: 456 Z-score: 318.3 bits: 66.2 E(85289): 5.5e-11 Smith-Waterman score: 456; 45.8% identity (67.8% similar) in 177 aa overlap (16-185:4-174) 10 20 30 40 50 60 pF1KB4 MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVE ::...: : : : ::.: : :: ::::::: :: :.::: NP_008 MSGCRVFIGRLNPAAREKDVERFFKGYGRIRDIDLK--RG---FGFVE 10 20 30 40 70 80 90 100 110 pF1KB4 FEDPRDAEDAVYGRDGYDYDGYRLRVEFPRS-GRGTGRGGGGGG---GGGAPRG-RYGPP :::::::.:::: :: . . :. .: :. .:: ::: : . .. ::. : . : NP_008 FEDPRDADDAVYELDGKELCSERVTIEHARARSRG-GRGRGRYSDRFSSRRPRNDRRNAP 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB4 SRRSENRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRD--GTGVVEFVRKEDMTYAVR :.:::..: .: ::::::: ::.::.: .::..: . :::::. :. :.. NP_008 PVRTENRLIVENLSSRVSWQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIE 110 120 130 140 150 160 180 190 200 pF1KB4 KLDNTKFRSHEVGYTRILFFDQNWIQWS ::.. .. .... NP_008 KLSGKEINGRKIKLIEGSKRHSRSRSRSRSRTRSSSRSRSRSRSRSRKSYSRSRSRSRSR 170 180 190 200 210 220 201 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 15:19:52 2016 done: Thu Nov 3 15:19:53 2016 Total Scan time: 6.390 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]