FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4680, 522 aa 1>>>pF1KB4680 522 - 522 aa - 522 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.5710+/-0.000576; mu= 4.0850+/- 0.035 mean_var=411.1585+/-99.123, 0's: 0 Z-trim(116.0): 1595 B-trim: 1380 in 1/52 Lambda= 0.063251 statistics sampled from 24646 (26811) to 24646 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.672), E-opt: 0.2 (0.314), width: 16 Scan time: 10.880 The best scores are: opt bits E(85289) XP_005273063 (OMIM: 608433,612337) PREDICTED: zinc ( 522) 3510 335.6 2.2e-91 XP_016855549 (OMIM: 608433,612337) PREDICTED: zinc ( 522) 3510 335.6 2.2e-91 NP_006343 (OMIM: 608433,612337) zinc finger and BT ( 522) 3510 335.6 2.2e-91 NP_001265125 (OMIM: 608433,612337) zinc finger and ( 522) 3510 335.6 2.2e-91 NP_991331 (OMIM: 608433,612337) zinc finger and BT ( 531) 3510 335.6 2.2e-91 XP_016876400 (OMIM: 613915,616248) PREDICTED: zinc ( 422) 791 87.3 9.7e-17 NP_001131073 (OMIM: 613915,616248) zinc finger and ( 422) 791 87.3 9.7e-17 NP_001311067 (OMIM: 604084) zinc finger and BTB do ( 740) 447 56.3 3.7e-07 XP_005246043 (OMIM: 604084) PREDICTED: zinc finger ( 747) 447 56.3 3.7e-07 XP_006723763 (OMIM: 614639) PREDICTED: zinc finger ( 589) 418 53.5 2e-06 XP_005260253 (OMIM: 614639) PREDICTED: zinc finger ( 589) 418 53.5 2e-06 XP_005260252 (OMIM: 614639) PREDICTED: zinc finger ( 589) 418 53.5 2e-06 NP_079500 (OMIM: 614639) zinc finger and BTB domai ( 589) 418 53.5 2e-06 XP_005260255 (OMIM: 614639) PREDICTED: zinc finger ( 589) 418 53.5 2e-06 XP_011526850 (OMIM: 614639) PREDICTED: zinc finger ( 589) 418 53.5 2e-06 XP_005260254 (OMIM: 614639) PREDICTED: zinc finger ( 589) 418 53.5 2e-06 NP_055687 (OMIM: 616590) zinc finger and BTB domai ( 677) 387 50.8 1.6e-05 XP_005251691 (OMIM: 616590) PREDICTED: zinc finger ( 677) 387 50.8 1.6e-05 XP_011511718 (OMIM: 616238) PREDICTED: zinc finger ( 643) 376 49.7 3e-05 XP_011524172 (OMIM: 616591) PREDICTED: zinc finger ( 619) 343 46.7 0.00024 XP_005258286 (OMIM: 616591) PREDICTED: zinc finger ( 619) 343 46.7 0.00024 NP_001305770 (OMIM: 616591) zinc finger and BTB do ( 619) 343 46.7 0.00024 XP_011524173 (OMIM: 616591) PREDICTED: zinc finger ( 619) 343 46.7 0.00024 NP_001034449 (OMIM: 616591) zinc finger and BTB do ( 619) 343 46.7 0.00024 XP_016881098 (OMIM: 616591) PREDICTED: zinc finger ( 619) 343 46.7 0.00024 XP_011524171 (OMIM: 616591) PREDICTED: zinc finger ( 627) 343 46.7 0.00024 XP_016881097 (OMIM: 616591) PREDICTED: zinc finger ( 627) 343 46.7 0.00024 XP_011524168 (OMIM: 616591) PREDICTED: zinc finger ( 628) 343 46.7 0.00024 XP_011524165 (OMIM: 616591) PREDICTED: zinc finger ( 628) 343 46.7 0.00024 XP_011524169 (OMIM: 616591) PREDICTED: zinc finger ( 628) 343 46.7 0.00024 XP_011524166 (OMIM: 616591) PREDICTED: zinc finger ( 628) 343 46.7 0.00024 XP_011524167 (OMIM: 616591) PREDICTED: zinc finger ( 628) 343 46.7 0.00024 XP_016881096 (OMIM: 616591) PREDICTED: zinc finger ( 628) 343 46.7 0.00024 XP_016881095 (OMIM: 616591) PREDICTED: zinc finger ( 628) 343 46.7 0.00024 XP_011524163 (OMIM: 616591) PREDICTED: zinc finger ( 668) 343 46.8 0.00025 XP_016881094 (OMIM: 616591) PREDICTED: zinc finger ( 668) 343 46.8 0.00025 XP_011524471 (OMIM: 604760) PREDICTED: zinc finger (1540) 347 47.7 0.00031 XP_011524470 (OMIM: 604760) PREDICTED: zinc finger (1560) 347 47.7 0.00031 XP_011524468 (OMIM: 604760) PREDICTED: zinc finger (1706) 347 47.7 0.00032 XP_005266819 (OMIM: 604760) PREDICTED: zinc finger (1790) 347 47.8 0.00033 XP_011524467 (OMIM: 604760) PREDICTED: zinc finger (1845) 347 47.8 0.00034 NP_031371 (OMIM: 604760) zinc finger protein 236 i (1845) 347 47.8 0.00034 NP_001293018 (OMIM: 604760) zinc finger protein 23 (1847) 347 47.8 0.00034 XP_016878339 (OMIM: 604191) PREDICTED: zinc finger ( 479) 326 45.0 0.00061 XP_006720897 (OMIM: 604191) PREDICTED: zinc finger ( 479) 326 45.0 0.00061 XP_006720896 (OMIM: 604191) PREDICTED: zinc finger ( 598) 326 45.1 0.00069 XP_006720895 (OMIM: 604191) PREDICTED: zinc finger ( 644) 326 45.2 0.00072 XP_006720894 (OMIM: 604191) PREDICTED: zinc finger ( 670) 326 45.2 0.00074 XP_011520646 (OMIM: 604191) PREDICTED: zinc finger ( 683) 326 45.2 0.00074 NP_005732 (OMIM: 604191) zinc finger protein 263 [ ( 683) 326 45.2 0.00074 >>XP_005273063 (OMIM: 608433,612337) PREDICTED: zinc fin (522 aa) initn: 3510 init1: 3510 opt: 3510 Z-score: 1761.6 bits: 335.6 E(85289): 2.2e-91 Smith-Waterman score: 3510; 100.0% identity (100.0% similar) in 522 aa overlap (1-522:1-522) 10 20 30 40 50 60 pF1KB4 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 DIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 ATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILPSKRDLAAEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILPSKRDLAAEP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 GNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 DLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKES 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 VSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLLPYVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLLPYVS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 NILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 CMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGD 430 440 450 460 470 480 490 500 510 520 pF1KB4 LYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK :::::::::::::::::::::::::::::::::::::::::: XP_005 LYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK 490 500 510 520 >>XP_016855549 (OMIM: 608433,612337) PREDICTED: zinc fin (522 aa) initn: 3510 init1: 3510 opt: 3510 Z-score: 1761.6 bits: 335.6 E(85289): 2.2e-91 Smith-Waterman score: 3510; 100.0% identity (100.0% similar) in 522 aa overlap (1-522:1-522) 10 20 30 40 50 60 pF1KB4 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 DIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 ATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILPSKRDLAAEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILPSKRDLAAEP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 GNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 DLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKES 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 VSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLLPYVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLLPYVS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 NILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 CMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGD 430 440 450 460 470 480 490 500 510 520 pF1KB4 LYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK :::::::::::::::::::::::::::::::::::::::::: XP_016 LYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK 490 500 510 520 >>NP_006343 (OMIM: 608433,612337) zinc finger and BTB do (522 aa) initn: 3510 init1: 3510 opt: 3510 Z-score: 1761.6 bits: 335.6 E(85289): 2.2e-91 Smith-Waterman score: 3510; 100.0% identity (100.0% similar) in 522 aa overlap (1-522:1-522) 10 20 30 40 50 60 pF1KB4 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 DIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 ATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILPSKRDLAAEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILPSKRDLAAEP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 GNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 DLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKES 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 VSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLLPYVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLLPYVS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 NILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 NILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 CMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 CMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGD 430 440 450 460 470 480 490 500 510 520 pF1KB4 LYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK :::::::::::::::::::::::::::::::::::::::::: NP_006 LYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK 490 500 510 520 >>NP_001265125 (OMIM: 608433,612337) zinc finger and BTB (522 aa) initn: 3510 init1: 3510 opt: 3510 Z-score: 1761.6 bits: 335.6 E(85289): 2.2e-91 Smith-Waterman score: 3510; 100.0% identity (100.0% similar) in 522 aa overlap (1-522:1-522) 10 20 30 40 50 60 pF1KB4 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 DIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 ATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILPSKRDLAAEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILPSKRDLAAEP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 GNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 DLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKES 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 VSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLLPYVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLLPYVS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 NILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 CMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGD 430 440 450 460 470 480 490 500 510 520 pF1KB4 LYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK :::::::::::::::::::::::::::::::::::::::::: NP_001 LYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK 490 500 510 520 >>NP_991331 (OMIM: 608433,612337) zinc finger and BTB do (531 aa) initn: 3510 init1: 3510 opt: 3510 Z-score: 1761.5 bits: 335.6 E(85289): 2.2e-91 Smith-Waterman score: 3510; 100.0% identity (100.0% similar) in 522 aa overlap (1-522:10-531) 10 20 30 40 50 pF1KB4 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHL ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_991 MCPKGYEDSMEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 FYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_991 FYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 VCKKKLKEKATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_991 VCKKKLKEKATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB4 SKRDLAAEPGNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_991 SKRDLAAEPGNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVR 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB4 DSADVDCVLDLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_991 DSADVDCVLDLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYD 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB4 MEHSTVKESVSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_991 MEHSTVKESVSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGM 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB4 ESSLLPYVSNILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_991 ESSLLPYVSNILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPT 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB4 CSLCGKTFSCMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_991 CSLCGKTFSCMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWC 430 440 450 460 470 480 480 490 500 510 520 pF1KB4 ERRFTQSGDLYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_991 ERRFTQSGDLYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK 490 500 510 520 530 >>XP_016876400 (OMIM: 613915,616248) PREDICTED: zinc fin (422 aa) initn: 1578 init1: 767 opt: 791 Z-score: 421.6 bits: 87.3 E(85289): 9.7e-17 Smith-Waterman score: 1267; 45.6% identity (63.1% similar) in 502 aa overlap (1-498:1-422) 10 20 30 40 50 pF1KB4 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQ-LDK ::::.:. .:: : .::. :::::::::::::.: :::::::.::.::::::.:. . XP_016 MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 RDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKE :: :.::.::::::::. ::.:::::.:....::.:::::::::::::::::::: .:.: XP_016 RDTVRLNGDIVTAPAFGRLLDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLQE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 KATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDE-KLNILPSKRDLAA : :. ::. :. : :.. .. :. : XP_016 K------------------DR--SLDPGNP-APGAEPAQPPCPWPVWTADLCPAARKAKL 130 140 150 180 190 200 210 220 230 pF1KB4 EPGNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDC : .. :: ..: : ::. : . : XP_016 PPFGVKAALPPRASGPP-------------------PCQVPE--------------ESDQ 160 170 180 240 250 260 270 280 290 pF1KB4 VLDLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDY--DMEHST .::::.::. . ::.. : :.. . :.. : . : XP_016 ALDLSLKSGPR------QERVHPPCVLQTPL----------CSQRQPGAQPLVKDERDSL 190 200 210 220 230 300 310 320 330 340 350 pF1KB4 VKESVSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLL .. :...: . : . :. . : . : . :..... .: .: XP_016 SEQEESSSSRSPHSPPKPPPVPAAKGLVVGLQPLPLSGEG-----SRELELGAGRLAS-- 240 250 260 270 280 360 370 380 390 400 410 pF1KB4 PYVSNILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCG . :.:.: . .::::.:.::: :.::.:::.::::.:. :.. . : .::: ::: XP_016 ---EDELGPGGPLCICPLCSKLFPSSHVLQLHLSAHFRERDSTRARLSPDGVAPTCPLCG 290 300 310 320 330 340 420 430 440 450 460 470 pF1KB4 KTFSCMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFT ::::: ::::::::::::::::::.:::::::::::::::.:::::::::::.::::::: XP_016 KTFSCTYTLKRHERTHSGEKPYTCVQCGKSFQYSHNLSRHTVVHTREKPHACRWCERRFT 350 360 370 380 390 400 480 490 500 510 520 pF1KB4 QSGDLYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK ::::::::.::::: ::.:: : XP_016 QSGDLYRHVRKFHCGLVKSLLV 410 420 >>NP_001131073 (OMIM: 613915,616248) zinc finger and BTB (422 aa) initn: 1578 init1: 767 opt: 791 Z-score: 421.6 bits: 87.3 E(85289): 9.7e-17 Smith-Waterman score: 1267; 45.6% identity (63.1% similar) in 502 aa overlap (1-498:1-422) 10 20 30 40 50 pF1KB4 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQ-LDK ::::.:. .:: : .::. :::::::::::::.: :::::::.::.::::::.:. . NP_001 MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 RDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKE :: :.::.::::::::. ::.:::::.:....::.:::::::::::::::::::: .:.: NP_001 RDTVRLNGDIVTAPAFGRLLDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLQE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 KATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDE-KLNILPSKRDLAA : :. ::. :. : :.. .. :. : NP_001 K------------------DR--SLDPGNP-APGAEPAQPPCPWPVWTADLCPAARKAKL 130 140 150 180 190 200 210 220 230 pF1KB4 EPGNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDC : .. :: ..: : ::. : . : NP_001 PPFGVKAALPPRASGPP-------------------PCQVPE--------------ESDQ 160 170 180 240 250 260 270 280 290 pF1KB4 VLDLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDY--DMEHST .::::.::. . ::.. : :.. . :.. : . : NP_001 ALDLSLKSGPR------QERVHPPCVLQTPL----------CSQRQPGAQPLVKDERDSL 190 200 210 220 230 300 310 320 330 340 350 pF1KB4 VKESVSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLL .. :...: . : . :. . : . : . :..... .: .: NP_001 SEQEESSSSRSPHSPPKPPPVPAAKGLVVGLQPLPLSGEG-----SRELELGAGRLAS-- 240 250 260 270 280 360 370 380 390 400 410 pF1KB4 PYVSNILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCG . :.:.: . .::::.:.::: :.::.:::.::::.:. :.. . : .::: ::: NP_001 ---EDELGPGGPLCICPLCSKLFPSSHVLQLHLSAHFRERDSTRARLSPDGVAPTCPLCG 290 300 310 320 330 340 420 430 440 450 460 470 pF1KB4 KTFSCMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFT ::::: ::::::::::::::::::.:::::::::::::::.:::::::::::.::::::: NP_001 KTFSCTYTLKRHERTHSGEKPYTCVQCGKSFQYSHNLSRHTVVHTREKPHACRWCERRFT 350 360 370 380 390 400 480 490 500 510 520 pF1KB4 QSGDLYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK ::::::::.::::: ::.:: : NP_001 QSGDLYRHVRKFHCGLVKSLLV 410 420 >>NP_001311067 (OMIM: 604084) zinc finger and BTB domain (740 aa) initn: 1318 init1: 260 opt: 447 Z-score: 249.5 bits: 56.3 E(85289): 3.7e-07 Smith-Waterman score: 513; 26.5% identity (53.0% similar) in 536 aa overlap (1-504:1-511) 10 20 30 40 50 60 pF1KB4 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKR :.::.::.:.:. :..::. :.::::: .: ..:.::.::::.:: ::.... :: . NP_001 MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVHFKAHKAVLAACSEYFKMLFVDQ---K 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 DIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK :.::: :: .: : . : :. . : . . .. . .: . .. NP_001 DVVHL--DISNA---AGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQS 60 70 80 90 100 110 130 140 150 160 170 pF1KB4 ATTEADSTKKEEDASSCSDKVESLSDGSSHIAG-DLPSDEDEGEDEKLNILPSKRDLAAE :.. :..:.: :: :: : .: .:. . . .:. ...... :... . : NP_001 AASGAEQTEKA-DAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEPARK--GEE 120 130 140 150 160 180 190 200 210 220 230 pF1KB4 PGNMWMRLPSDSAG---IPQAGGEAEPHATAAGKTVASPCSSTESLSQ--RSVTSVRDSA . . ..:: . . :.. : .. : .. ..:.: .. . ..:... NP_001 EQKEQEEQEEEGAGPAEVKEEGSQLE-NGEAPEENENEESAGTDSGQELGSEARGLRSGT 170 180 190 200 210 220 240 250 260 270 280 pF1KB4 DVDCVLDLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTND----- : . . . : . :. .. . . . : ... :: :: : . . .: NP_001 YGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTG-EKPFSCRECSKAFSDPAACK 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB4 -YDMEHSTVKESVSTNNRVQYEPAHLAPLREDSVLRELD-REDKASDDEMMTPESERVQ- .. :: .: . .:. : :.. : : . . . . .: : NP_001 AHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLKRHQL 290 300 310 320 330 340 350 360 370 380 390 pF1KB4 VEGGMESSLLPYVSNILS-PAGQI-----------FMCPLCNKVFPSPHILQIHLSTHFR :..: . : . .: :.... :: :.: : . :. ::. :. NP_001 VHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLKIHI- 350 360 370 380 390 400 400 410 420 430 440 450 pF1KB4 EQDGIRSKPAADVNVPTCSLCGKTFSCMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLS :: : : ::: :. .:::: : :::::::.: .: ..: :. NP_001 -ADG----PLK------CRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQ 410 420 430 440 450 460 470 480 490 500 pF1KB4 RHAVVHTREKPHACKWCERRFTQSGDLYRHIRK------FHCELVNSLSVKSEALSLPTV ::. .:: ::: : : . :::...: :.:. . :: .. :.: :. NP_001 RHVRIHTGEKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIR 460 470 480 490 500 510 510 520 pF1KB4 RDWTLEDSSQELWK NP_001 HHDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQ 520 530 540 550 560 570 >>XP_005246043 (OMIM: 604084) PREDICTED: zinc finger and (747 aa) initn: 1318 init1: 260 opt: 447 Z-score: 249.5 bits: 56.3 E(85289): 3.7e-07 Smith-Waterman score: 513; 26.5% identity (53.0% similar) in 536 aa overlap (1-504:1-511) 10 20 30 40 50 60 pF1KB4 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKR :.::.::.:.:. :..::. :.::::: .: ..:.::.::::.:: ::.... :: . XP_005 MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVHFKAHKAVLAACSEYFKMLFVDQ---K 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 DIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK :.::: :: .: : . : :. . : . . .. . .: . .. XP_005 DVVHL--DISNA---AGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQS 60 70 80 90 100 110 130 140 150 160 170 pF1KB4 ATTEADSTKKEEDASSCSDKVESLSDGSSHIAG-DLPSDEDEGEDEKLNILPSKRDLAAE :.. :..:.: :: :: : .: .:. . . .:. ...... :... . : XP_005 AASGAEQTEKA-DAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEPARK--GEE 120 130 140 150 160 180 190 200 210 220 230 pF1KB4 PGNMWMRLPSDSAG---IPQAGGEAEPHATAAGKTVASPCSSTESLSQ--RSVTSVRDSA . . ..:: . . :.. : .. : .. ..:.: .. . ..:... XP_005 EQKEQEEQEEEGAGPAEVKEEGSQLE-NGEAPEENENEESAGTDSGQELGSEARGLRSGT 170 180 190 200 210 220 240 250 260 270 280 pF1KB4 DVDCVLDLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTND----- : . . . : . :. .. . . . : ... :: :: : . . .: XP_005 YGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTG-EKPFSCRECSKAFSDPAACK 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB4 -YDMEHSTVKESVSTNNRVQYEPAHLAPLREDSVLRELD-REDKASDDEMMTPESERVQ- .. :: .: . .:. : :.. : : . . . . .: : XP_005 AHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLKRHQL 290 300 310 320 330 340 350 360 370 380 390 pF1KB4 VEGGMESSLLPYVSNILS-PAGQI-----------FMCPLCNKVFPSPHILQIHLSTHFR :..: . : . .: :.... :: :.: : . :. ::. :. XP_005 VHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLKIHI- 350 360 370 380 390 400 400 410 420 430 440 450 pF1KB4 EQDGIRSKPAADVNVPTCSLCGKTFSCMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLS :: : : ::: :. .:::: : :::::::.: .: ..: :. XP_005 -ADG----PLK------CRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQ 410 420 430 440 450 460 470 480 490 500 pF1KB4 RHAVVHTREKPHACKWCERRFTQSGDLYRHIRK------FHCELVNSLSVKSEALSLPTV ::. .:: ::: : : . :::...: :.:. . :: .. :.: :. XP_005 RHVRIHTGEKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIR 460 470 480 490 500 510 510 520 pF1KB4 RDWTLEDSSQELWK XP_005 HHDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQ 520 530 540 550 560 570 >>XP_006723763 (OMIM: 614639) PREDICTED: zinc finger and (589 aa) initn: 595 init1: 214 opt: 418 Z-score: 236.2 bits: 53.5 E(85289): 2e-06 Smith-Waterman score: 474; 25.7% identity (54.7% similar) in 536 aa overlap (1-489:8-498) 10 20 30 40 50 pF1KB4 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFY ::. .: ::::. :.:::..: ::: :.: :.::. :: . : ::. .: XP_006 MNNRKEDMEITSHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLY 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 ---KDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIV . .. ..:: ::::: .: ...::: ..: . . . .:..:::.:.: ::: XP_006 CQVQKTSEQATVTHL--DIVTAQGFKAIIDFMYSAHLALTSRNVIEVMSAASFLQMTDIV 70 80 90 100 110 120 130 140 pF1KB4 KVCKKKLKEKATTEADSTKKEEDA-----SSCSDKVESL--------------------- ..:. .: : ..: : .: :...:.: XP_006 QACHDFIKAALDISIKSDASDELAEFEIGASSSSSTEALISAVMAGRSISPWLARRTSPA 120 130 140 150 160 170 150 160 170 180 190 pF1KB4 -SDGSSHIAGDLPSDEDEGEDEKLNILPSKRDLAAEPGNMW--------MRLPSDSAGIP :.:.: ::. . . :.... . :....: .: .:. .... XP_006 NSSGDSAIASCHDGGSSYGKEDQEPKADGPDDVSSQP--LWPGDVGYGPLRIKEEQVSPS 180 190 200 210 220 230 200 210 220 230 240 pF1KB4 QAGGEAEPHAT-AAGKTVASPCSSTESLSQRSVTSVRDSADV-----DCVLDLSVKSS-L : :: : : .: .. : :. .. . . . : . .. . : : : :: . XP_006 QYGGSELPSAKDGAVQNSFSEQSAGDAWQPTGRRKNRKNKETVRHITQQVEDDSRASSPV 240 250 260 270 280 290 250 260 270 280 290 300 pF1KB4 SGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKESVSTNNRVQ . .. :::.: :: ....: . .: : . .. .. :.:.. ..... XP_006 PSFLPTSGWPFSSRD---SN-ADLSVTEASSSD----SRGERAELYAQVEEGL-LGGEAS 300 310 320 330 340 310 320 330 340 350 360 pF1KB4 YEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLLPYVSNILSPAGQ : :.: ..:.. . . . .:. ..::: ...:. :. XP_006 YLGPPLTPEKDDALHQATAVANLRA--ALMS------------KNSLLSLKADVLGDDGS 350 360 370 380 390 370 380 390 400 410 420 pF1KB4 IFMCPLCNKVFP-SPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFSCMYTLKR ... . .: . : :... : .:.. . : ::. . .:. ::: XP_006 LLF-----EYLPRGAHSLSLNEFTVIRKK----------FKCPYCSF-SAMHQCI--LKR 400 410 420 430 430 440 450 460 470 480 pF1KB4 HERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGDL-YRHIR : :.:.::.:: : :::.: ....::..::...: ..:: : : : ..... :: XP_006 HMRSHTGERPYPCEICGKKFTRREHMKRHTLVHSKDKKYVCKVCSRVFMSAASVGIRHGS 440 450 460 470 480 490 490 500 510 520 pF1KB4 KFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK . : XP_006 RRHGVCTDCAGRGMAGPLDHGGGGGEGSPEALFPGDGPYLEDPEDPRGEAEELGEDDEGL 500 510 520 530 540 550 522 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 15:21:04 2016 done: Thu Nov 3 15:21:06 2016 Total Scan time: 10.880 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]