FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4699, 370 aa 1>>>pF1KB4699 370 - 370 aa - 370 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.5974+/-0.000405; mu= 21.1148+/- 0.025 mean_var=127.2651+/-33.228, 0's: 0 Z-trim(112.3): 499 B-trim: 1217 in 1/51 Lambda= 0.113689 statistics sampled from 20441 (21116) to 20441 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.602), E-opt: 0.2 (0.248), width: 16 Scan time: 8.100 The best scores are: opt bits E(85289) NP_061843 (OMIM: 605188) probable G-protein couple ( 370) 2519 425.2 1.2e-118 NP_001139738 (OMIM: 605188) probable G-protein cou ( 370) 2519 425.2 1.2e-118 XP_016867841 (OMIM: 605188) PREDICTED: probable G- ( 370) 2519 425.2 1.2e-118 XP_005250508 (OMIM: 605188) PREDICTED: probable G- ( 370) 2519 425.2 1.2e-118 NP_001139737 (OMIM: 605188) probable G-protein cou ( 370) 2519 425.2 1.2e-118 NP_001139739 (OMIM: 605188) probable G-protein cou ( 370) 2519 425.2 1.2e-118 NP_061842 (OMIM: 300253) probable G-protein couple ( 373) 1687 288.7 1.5e-77 XP_011529100 (OMIM: 300253) PREDICTED: probable G- ( 373) 1687 288.7 1.5e-77 NP_061844 (OMIM: 605187) probable G-protein couple ( 375) 1322 228.8 1.5e-59 NP_001307687 (OMIM: 601122) 5-hydroxytryptamine re ( 439) 316 63.9 7.9e-10 XP_006712545 (OMIM: 601122) PREDICTED: 5-hydroxytr ( 456) 316 64.0 8e-10 NP_000858 (OMIM: 601122) 5-hydroxytryptamine recep ( 481) 316 64.0 8.2e-10 NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 315 63.8 9.2e-10 NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458) 297 60.8 7e-09 NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 297 60.8 7e-09 NP_076917 (OMIM: 601305) 5-hydroxytryptamine recep ( 357) 292 59.9 1.1e-08 NP_000721 (OMIM: 118444) cholecystokinin receptor ( 428) 292 60.0 1.2e-08 NP_005949 (OMIM: 600665) melatonin receptor type 1 ( 350) 271 56.4 1.2e-07 NP_005950 (OMIM: 125853,600804) melatonin receptor ( 362) 264 55.3 2.6e-07 XP_011541141 (OMIM: 125853,600804) PREDICTED: mela ( 362) 264 55.3 2.6e-07 XP_011531966 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 262 55.0 3.3e-07 NP_000857 (OMIM: 182134) 5-hydroxytryptamine recep ( 366) 262 55.0 3.3e-07 NP_001309137 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 262 55.0 3.3e-07 NP_001309139 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 262 55.0 3.3e-07 NP_001309138 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 262 55.0 3.3e-07 XP_005264808 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 262 55.0 3.3e-07 NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 262 55.1 3.8e-07 XP_016881180 (OMIM: 600377) PREDICTED: galanin rec ( 269) 259 54.2 4e-07 NP_001471 (OMIM: 600377) galanin receptor type 1 [ ( 349) 259 54.4 4.5e-07 NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462) 257 54.3 6.6e-07 NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 251 53.2 1.2e-06 NP_000856 (OMIM: 182132) 5-hydroxytryptamine recep ( 365) 250 53.0 1.3e-06 XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytr ( 365) 250 53.0 1.3e-06 NP_057658 (OMIM: 126450,159900) D(2) dopamine rece ( 414) 250 53.1 1.4e-06 NP_000786 (OMIM: 126450,159900) D(2) dopamine rece ( 443) 250 53.1 1.4e-06 XP_016872785 (OMIM: 126450,159900) PREDICTED: D(2) ( 443) 250 53.1 1.4e-06 NP_001548 (OMIM: 146928) C-X-C chemokine receptor ( 360) 243 51.8 2.8e-06 XP_005246587 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 243 51.8 2.8e-06 XP_016859480 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 243 51.8 2.8e-06 XP_016859481 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 243 51.8 2.8e-06 XP_016859479 (OMIM: 146928) PREDICTED: C-X-C chemo ( 360) 243 51.8 2.8e-06 NP_001161770 (OMIM: 146928) C-X-C chemokine recept ( 360) 243 51.8 2.8e-06 NP_001287 (OMIM: 602648) atypical chemokine recept ( 384) 242 51.7 3.3e-06 XP_005246577 (OMIM: 601122) PREDICTED: 5-hydroxytr ( 362) 241 51.5 3.6e-06 NP_001286 (OMIM: 601159) C-C chemokine receptor ty ( 355) 240 51.3 4e-06 NP_004239 (OMIM: 600895) prolactin-releasing pepti ( 370) 240 51.4 4.1e-06 NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471) 241 51.7 4.1e-06 XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 239 51.1 4.3e-06 XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 239 51.1 4.3e-06 XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 239 51.2 4.5e-06 >>NP_061843 (OMIM: 605188) probable G-protein coupled re (370 aa) initn: 2519 init1: 2519 opt: 2519 Z-score: 2251.0 bits: 425.2 E(85289): 1.2e-118 Smith-Waterman score: 2519; 100.0% identity (100.0% similar) in 370 aa overlap (1-370:1-370) 10 20 30 40 50 60 pF1KB4 MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 DLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 DLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 LAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 LAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 ANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 ANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 ANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 ANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 YLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 YLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKS 310 320 330 340 350 360 370 pF1KB4 RLPREPYCVI :::::::::: NP_061 RLPREPYCVI 370 >>NP_001139738 (OMIM: 605188) probable G-protein coupled (370 aa) initn: 2519 init1: 2519 opt: 2519 Z-score: 2251.0 bits: 425.2 E(85289): 1.2e-118 Smith-Waterman score: 2519; 100.0% identity (100.0% similar) in 370 aa overlap (1-370:1-370) 10 20 30 40 50 60 pF1KB4 MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 DLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 LAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 ANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 ANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 YLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKS 310 320 330 340 350 360 370 pF1KB4 RLPREPYCVI :::::::::: NP_001 RLPREPYCVI 370 >>XP_016867841 (OMIM: 605188) PREDICTED: probable G-prot (370 aa) initn: 2519 init1: 2519 opt: 2519 Z-score: 2251.0 bits: 425.2 E(85289): 1.2e-118 Smith-Waterman score: 2519; 100.0% identity (100.0% similar) in 370 aa overlap (1-370:1-370) 10 20 30 40 50 60 pF1KB4 MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 DLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 LAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 ANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 ANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 YLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKS 310 320 330 340 350 360 370 pF1KB4 RLPREPYCVI :::::::::: XP_016 RLPREPYCVI 370 >>XP_005250508 (OMIM: 605188) PREDICTED: probable G-prot (370 aa) initn: 2519 init1: 2519 opt: 2519 Z-score: 2251.0 bits: 425.2 E(85289): 1.2e-118 Smith-Waterman score: 2519; 100.0% identity (100.0% similar) in 370 aa overlap (1-370:1-370) 10 20 30 40 50 60 pF1KB4 MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 DLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 LAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 ANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 ANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 YLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKS 310 320 330 340 350 360 370 pF1KB4 RLPREPYCVI :::::::::: XP_005 RLPREPYCVI 370 >>NP_001139737 (OMIM: 605188) probable G-protein coupled (370 aa) initn: 2519 init1: 2519 opt: 2519 Z-score: 2251.0 bits: 425.2 E(85289): 1.2e-118 Smith-Waterman score: 2519; 100.0% identity (100.0% similar) in 370 aa overlap (1-370:1-370) 10 20 30 40 50 60 pF1KB4 MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 DLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 LAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 ANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 ANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 YLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKS 310 320 330 340 350 360 370 pF1KB4 RLPREPYCVI :::::::::: NP_001 RLPREPYCVI 370 >>NP_001139739 (OMIM: 605188) probable G-protein coupled (370 aa) initn: 2519 init1: 2519 opt: 2519 Z-score: 2251.0 bits: 425.2 E(85289): 1.2e-118 Smith-Waterman score: 2519; 100.0% identity (100.0% similar) in 370 aa overlap (1-370:1-370) 10 20 30 40 50 60 pF1KB4 MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 DLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 LAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSFR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 ANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQAA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 ANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLWGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 YLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCRKS 310 320 330 340 350 360 370 pF1KB4 RLPREPYCVI :::::::::: NP_001 RLPREPYCVI 370 >>NP_061842 (OMIM: 300253) probable G-protein coupled re (373 aa) initn: 1722 init1: 1293 opt: 1687 Z-score: 1513.4 bits: 288.7 E(85289): 1.5e-77 Smith-Waterman score: 1687; 62.4% identity (86.9% similar) in 375 aa overlap (1-370:1-373) 10 20 30 40 50 pF1KB4 MANYSHAADNILQNLSP--LTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYF ::: . ... ::: .:..::. ::.:. ::..:: ..:.:..:...::.::::: NP_061 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 LLDLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVT ::::: .: .:::.:::::. ::..::.::...:.::..::..:: :::.:::::::::: NP_061 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 RYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRS ::.::::::::.::.:.::: :::::.::::::::::::.:::::.:::::::: :.:: NP_061 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB4 FRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQ :.:::.:::::.::... ::. :: ::..: . .:::::::.: :.:::::::::::.:: NP_061 FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB4 AAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLW :::::.::::::: ::::::::::.....:: :: .:: : ::...:::: .:.::: :: NP_061 AAANWIAGFGRGPMPPTLLGIRQNGHAASRR-LLGMDEVKGEKQLGRMFYAITLLFLLLW 250 260 270 280 290 300 310 320 330 340 350 pF1KB4 GPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCR .::.::::::::... .:: .:..:::::::::..::.::.. :..:..:. : : NP_061 SPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHA-PCW 300 310 320 330 340 350 360 370 pF1KB4 KSR---LPREPYCVI . :::::::. NP_061 GTGGAPAPREPYCVM 360 370 >>XP_011529100 (OMIM: 300253) PREDICTED: probable G-prot (373 aa) initn: 1722 init1: 1293 opt: 1687 Z-score: 1513.4 bits: 288.7 E(85289): 1.5e-77 Smith-Waterman score: 1687; 62.4% identity (86.9% similar) in 375 aa overlap (1-370:1-373) 10 20 30 40 50 pF1KB4 MANYSHAADNILQNLSP--LTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYF ::: . ... ::: .:..::. ::.:. ::..:: ..:.:..:...::.::::: XP_011 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 LLDLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVT ::::: .: .:::.:::::. ::..::.::...:.::..::..:: :::.:::::::::: XP_011 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 RYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRS ::.::::::::.::.:.::: :::::.::::::::::::.:::::.:::::::: :.:: XP_011 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB4 FRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQ :.:::.:::::.::... ::. :: ::..: . .:::::::.: :.:::::::::::.:: XP_011 FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB4 AAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLW :::::.::::::: ::::::::::.....:: :: .:: : ::...:::: .:.::: :: XP_011 AAANWIAGFGRGPMPPTLLGIRQNGHAASRR-LLGMDEVKGEKQLGRMFYAITLLFLLLW 250 260 270 280 290 300 310 320 330 340 350 pF1KB4 GPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLYCR .::.::::::::... .:: .:..:::::::::..::.::.. :..:..:. : : XP_011 SPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHA-PCW 300 310 320 330 340 350 360 370 pF1KB4 KSR---LPREPYCVI . :::::::. XP_011 GTGGAPAPREPYCVM 360 370 >>NP_061844 (OMIM: 605187) probable G-protein coupled re (375 aa) initn: 1263 init1: 802 opt: 1322 Z-score: 1189.9 bits: 228.8 E(85289): 1.5e-59 Smith-Waterman score: 1322; 55.2% identity (82.3% similar) in 344 aa overlap (22-361:20-360) 10 20 30 40 50 60 pF1KB4 MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLL :::..:.... ::..::.:...:.:....:::::::.:: NP_061 MANASEPGGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYLLL 10 20 30 40 50 70 80 90 100 110 pF1KB4 DLCCSDILRSAICFPFVFNSVKNGSTWTY---GTLTCKVIAFLGVLSCFHTAFMLFCISV ::: .: ::. :.: :. ... ... . :.: ::..:::..: :::.::.:. ..: NP_061 DLCLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGVGV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 TRYLAIAHHRFYTKRLTFWTCLAV-ICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQH ::::::::::::..::. : : :. .: .:.:..: ::::::: : . :. :.... NP_061 TRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGDD---EDAPCALEQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB4 RSFRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGAS : : .:::.::::... ::.::::.:.::.::::::.:...: :::..::::::::. NP_061 RPDGAPGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPGAT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB4 GQAAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLT ::::::: ::::::::::.:.::: . : ::::::.::: :::. .::: .:.::: NP_061 GQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLFLL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB4 LWGPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFSTTLLY :::::.:: : ::..: .:: ..:::.::..:::::::: ::.. ::::: :: . . NP_061 LWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQFPC 300 310 320 330 340 350 360 370 pF1KB4 CRKSRLPREPYCVI :.. : NP_061 CQSPRTTQATHPCDLKGIGL 360 370 >>NP_001307687 (OMIM: 601122) 5-hydroxytryptamine recept (439 aa) initn: 297 init1: 180 opt: 316 Z-score: 297.5 bits: 63.9 E(85289): 7.9e-10 Smith-Waterman score: 316; 25.4% identity (56.3% similar) in 339 aa overlap (30-350:22-349) 10 20 30 40 50 60 pF1KB4 MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLL .: .. :: :. . . .: :. : :::. NP_001 MKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLM 10 20 30 40 50 70 80 90 100 110 pF1KB4 DLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTA-FMLFC-ISVT .: .:.: . . .:... .. . : . : . :: :: : :: .: .: ::: NP_001 SLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVL--FSTASIMHLCAISVD 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 RYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFP-PVLDVGTYSFIREEDQCTFQHR ::.:: . .. . : . : .:: .:...:.: :. . : .. :.. .. NP_001 RYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKE 120 130 140 150 160 170 180 190 200 210 220 pF1KB4 SFRANDSLGFMLLLALILLATQLVYLKLIFF--VHDRRKM------KPVQFVAAVSQNWT : .: :::. .: . : :. . . .: .: .: :: : .. .. . . NP_001 RF--GD---FMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTV 180 190 200 210 220 230 240 250 260 270 280 pF1KB4 FH---GPGASGQAAANWLAGFGRGPTPPTLLG--IRQNANTTGRRRLLVLDEFKMEKRIS :. : .: . .: : : . . :. . . ..: :.. . .... :.: : NP_001 FQRDETPCSSPEKVA-MLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISN---EQRAS 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB4 RMFYIMTFLFLTLWGPYLVACYWRVFARG--PVVPGGFLTAAVWMSFAQAGINPFVCIFS ... :. :::: .: :.... :. . .. .: ::......:.::.: . NP_001 KVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLF 290 300 310 320 330 340 350 360 370 pF1KB4 NRELRRCFSTTLLYCRKSRLPREPYCVI :. .: : NP_001 NKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQ 350 360 370 380 390 400 370 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 15:24:09 2016 done: Thu Nov 3 15:24:11 2016 Total Scan time: 8.100 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]