FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB4718, 211 aa
  1>>>pF1KB4718 211 - 211 aa - 211 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.4019+/-0.000346; mu= 12.7105+/- 0.021
 mean_var=63.6044+/-12.484, 0's: 0 Z-trim(114.9): 10  B-trim: 0 in 0/54
 Lambda= 0.160817
 statistics sampled from 25045 (25053) to 25045 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.294), width:  16
 Scan time:  5.060

The best scores are:                                      opt bits E(85289)
NP_000353 (OMIM: 136900,188826) metalloproteinase  ( 211) 1527 362.7 2.6e-100
NP_003247 (OMIM: 601915) metalloproteinase inhibit ( 224)  706 172.2 5.9e-43
NP_003246 (OMIM: 188825) metalloproteinase inhibit ( 220)  686 167.6 1.4e-41
NP_003245 (OMIM: 305370) metalloproteinase inhibit ( 207)  528 130.9 1.5e-30
XP_016885255 (OMIM: 305370) PREDICTED: metalloprot ( 261)  134 39.5   0.006


>>NP_000353 (OMIM: 136900,188826) metalloproteinase inhi  (211 aa)
 initn: 1527 init1: 1527 opt: 1527  Z-score: 1922.0  bits: 362.7 E(85289): 2.6e-100
Smith-Waterman score: 1527; 100.0% identity (100.0% similar) in 211 aa overlap (1-211:1-211)

               10        20        30        40        50        60
pF1KB4 MTPWLGLIVLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRAKVVGKKLVKEGPFGTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MTPWLGLIVLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRAKVVGKKLVKEGPFGTL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 VYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVNKYQYLLTGRVYDGKMYTGLCNF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVNKYQYLLTGRVYDGKMYTGLCNF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 VERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWTDMLSNFGYPGYQSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWTDMLSNFGYPGYQSK
              130       140       150       160       170       180

              190       200       210 
pF1KB4 HYACIRQKGGYCSWYRGWAPPDKSIINATDP
       :::::::::::::::::::::::::::::::
NP_000 HYACIRQKGGYCSWYRGWAPPDKSIINATDP
              190       200       210 

>>NP_003247 (OMIM: 601915) metalloproteinase inhibitor 4  (224 aa)
 initn: 688 init1: 392 opt: 706  Z-score: 892.2  bits: 172.2 E(85289): 5.9e-43
Smith-Waterman score: 706; 47.4% identity (73.5% similar) in 215 aa overlap (4-211:11-224)

                      10        20        30        40        50   
pF1KB4        MTPWLGLIVLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRAKVVGKKLVK
                 :. :. ::.       : :::.:.:.:::. .:.: .:::::. ..:.: 
NP_003 MPGSPRPAPSWVLLLRLLALLRPPGLG-EACSCAPAHPQQHICHSALVIRAKISSEKVVP
               10        20         30        40        50         

                 60        70        80        90        100       
pF1KB4 EG--PFGT---LVYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVN-KYQYLLTGR
        .  :  :   : : :::.::..:: :.  ::::.:  . ::::.:::.: . ::::::.
NP_003 ASADPADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQ
      60        70        80        90       100       110         

        110       120       130       140       150       160      
pF1KB4 VY-DGKMYTGLCNFVERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWT
       :  :::..  :::..: :..:.: ::..::..:::.:.:.: .:: .:: ... ::::::
NP_003 VLSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWT
     120       130       140       150       160       170         

        170       180       190       200       210 
pF1KB4 DMLSNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP
       : : .    :::..::.:...  : ::::::  :  : ... ..:
NP_003 DWLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP
     180       190       200       210       220    

>>NP_003246 (OMIM: 188825) metalloproteinase inhibitor 2  (220 aa)
 initn: 616 init1: 456 opt: 686  Z-score: 867.2  bits: 167.6 E(85289): 1.4e-41
Smith-Waterman score: 686; 45.2% identity (75.4% similar) in 199 aa overlap (21-211:24-220)

                  10        20        30        40        50       
pF1KB4    MTPWLGLIVLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRAKVVGKKLVKEG--
                              :.::.::: :::.::::.:.:::::.:..: :  :  
NP_003 MGAAARTLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGND
               10        20        30        40        50        60

              60        70        80        90        100          
pF1KB4 ----PFGTLVYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVN-KYQYLLTGRVY-
           :.  . : :::.::..:  :   ...:.:  : ..::..:.:. : .::..:..  
NP_003 IYGNPIKRIQYEIKQIKMFKGPEK--DIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEG
               70        80          90       100       110        

     110       120       130       140       150       160         
pF1KB4 DGKMYTGLCNFVERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWTDML
       ::::.  ::.:.  :: :. .:.:.::.::..::.:::  : ..::...: .:::: : .
NP_003 DGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWV
      120       130       140       150       160       170        

     170       180       190       200       210 
pF1KB4 SNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP
       .. .  :.:.: .:::... : :.:::: ::: . ...  ::
NP_003 TEKNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP
      180       190       200       210       220

>>NP_003245 (OMIM: 305370) metalloproteinase inhibitor 1  (207 aa)
 initn: 512 init1: 160 opt: 528  Z-score: 669.5  bits: 130.9 E(85289): 1.5e-30
Smith-Waterman score: 528; 38.6% identity (65.8% similar) in 202 aa overlap (1-194:1-199)

                 10        20        30        40        50        
pF1KB4 MTPWLGLI--VLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRAKVVGKKLVKEGPFG
       :.:.  :   .::  : ..   ..:::: : ::: ::::::.::::: ::   :..  . 
NP_003 MAPFEPLASGILLLLWLIAP--SRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLY
               10        20          30        40        50        

       60        70           80        90         100       110   
pF1KB4 TLVYTIKQMKMYRGFTKM---PHVQYIHTEASESLCGL--KLEVNKYQYLLTGRVYDGKM
          : ::. :::.::  .     .....: : ::.::   . .  . ..:..:.. :: .
NP_003 QR-YEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLL
       60         70        80        90       100       110       

           120       130       140        150       160       170  
pF1KB4 YTGLCNFVERWDQLTLSQRKGLNYRYHLGCN-CKIKSCYYLPCFVTSKNECLWTDMLSNF
       .   :.::  :..:.:.::.:..  : .::. : .  :  .:: . : ..:::::.: . 
NP_003 HITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQG
       120       130       140       150       160       170       

            180       190       200       210 
pF1KB4 GYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP
       .  :.::.: ::. .. : :.:                 
NP_003 SEKGFQSRHLACLPREPGLCTWQSLRSQIA         
       180       190       200                

>>XP_016885255 (OMIM: 305370) PREDICTED: metalloproteina  (261 aa)
 initn: 164 init1: 129 opt: 134  Z-score: 173.9  bits: 39.5 E(85289): 0.006
Smith-Waterman score: 148; 30.4% identity (57.0% similar) in 79 aa overlap (106-184:104-168)

          80        90       100       110       120       130     
pF1KB4 MPHVQYIHTEASESLCGLKLEVNKYQYLLTGRVYDGKMYTGLCNFVERWDQLTLSQRKGL
                                     :.. :: ..   :.::  :..:.:.::.:.
XP_016 FSLSEGRAFGSLAAQPITSCLSVPAPPFSLGKLQDGLLHITTCSFVAPWNSLSLAQRRGF
            80        90       100       110       120       130   

         140       150       160       170       180       190     
pF1KB4 NYRYHLGCNCKIKSCYYLPCFVTSKNECLWTDMLSNFGYPGYQSKHYACIRQKGGYCSWY
       .  : .::.          : :..     ::   .. ..::   : .::           
XP_016 TKTYTVGCE---------ECTVSA-----WTLTSNGRSFPGPFPKSWACFLLPLAILCPC
           140                     150       160       170         

         200       210                                             
pF1KB4 RGWAPPDKSIINATDP                                            
                                                                   
XP_016 GCSPTLRAVPDLSCYFPKPETAPLQILAAPFPCVQYRVITCPSLVPLILPCDYSVIPLPV
     180       190       200       210       220       230         




211 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 03:11:36 2016 done: Fri Nov  4 03:11:36 2016
 Total Scan time:  5.060 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]