FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4737, 1366 aa 1>>>pF1KB4737 1366 - 1366 aa - 1366 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.3293+/-0.00148; mu= 3.5169+/- 0.090 mean_var=670.3646+/-136.785, 0's: 0 Z-trim(113.5): 243 B-trim: 0 in 0/53 Lambda= 0.049536 statistics sampled from 13874 (14098) to 13874 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.67), E-opt: 0.2 (0.433), width: 16 Scan time: 6.460 The best scores are: opt bits E(32554) CCDS34682.1 COL1A2 gene_id:1278|Hs108|chr7 (1366) 9990 730.7 6.6e-210 CCDS11561.1 COL1A1 gene_id:1277|Hs108|chr17 (1464) 5741 427.1 1.8e-118 CCDS8759.1 COL2A1 gene_id:1280|Hs108|chr12 (1418) 5238 391.1 1.1e-107 CCDS41778.1 COL2A1 gene_id:1280|Hs108|chr12 (1487) 5238 391.2 1.2e-107 CCDS33350.1 COL5A2 gene_id:1290|Hs108|chr2 (1499) 4602 345.7 5.7e-94 CCDS2297.1 COL3A1 gene_id:1281|Hs108|chr2 (1466) 4344 327.3 2e-88 CCDS12222.1 COL5A3 gene_id:50509|Hs108|chr19 (1745) 3869 293.4 3.6e-78 CCDS780.2 COL11A1 gene_id:1301|Hs108|chr1 (1690) 3662 278.6 1e-73 CCDS53348.1 COL11A1 gene_id:1301|Hs108|chr1 (1767) 3662 278.6 1e-73 CCDS778.1 COL11A1 gene_id:1301|Hs108|chr1 (1806) 3662 278.7 1e-73 CCDS6982.1 COL5A1 gene_id:1289|Hs108|chr9 (1838) 3510 267.8 2e-70 CCDS75932.1 COL5A1 gene_id:1289|Hs108|chr9 (1838) 3497 266.9 3.8e-70 CCDS43452.1 COL11A2 gene_id:1302|Hs108|chr6 (1650) 3316 253.9 2.8e-66 CCDS41353.1 COL24A1 gene_id:255631|Hs108|chr1 (1714) 3054 235.2 1.2e-60 CCDS6802.1 COL27A1 gene_id:85301|Hs108|chr9 (1860) 2933 226.6 5.1e-58 CCDS9511.1 COL4A1 gene_id:1282|Hs108|chr13 (1669) 2851 220.6 2.8e-56 CCDS42829.1 COL4A3 gene_id:1285|Hs108|chr2 (1670) 2820 218.4 1.3e-55 CCDS41297.1 COL16A1 gene_id:1307|Hs108|chr1 (1604) 2652 206.4 5.3e-52 CCDS76008.1 COL4A6 gene_id:1288|Hs108|chrX (1633) 2447 191.8 1.4e-47 CCDS76009.1 COL4A6 gene_id:1288|Hs108|chrX (1666) 2447 191.8 1.4e-47 CCDS14542.1 COL4A6 gene_id:1288|Hs108|chrX (1690) 2447 191.8 1.4e-47 CCDS14541.1 COL4A6 gene_id:1288|Hs108|chrX (1691) 2447 191.8 1.4e-47 CCDS6376.1 COL22A1 gene_id:169044|Hs108|chr8 (1626) 2414 189.4 7e-47 CCDS2773.1 COL7A1 gene_id:1294|Hs108|chr3 (2944) 2344 184.8 3.1e-45 CCDS42828.1 COL4A4 gene_id:1286|Hs108|chr2 (1690) 2201 174.2 2.7e-42 CCDS14543.1 COL4A5 gene_id:1287|Hs108|chrX (1685) 1988 159.0 1e-37 CCDS35366.1 COL4A5 gene_id:1287|Hs108|chrX (1691) 1988 159.0 1e-37 CCDS4970.1 COL19A1 gene_id:1310|Hs108|chr6 (1142) 1929 154.5 1.6e-36 CCDS13505.1 COL9A3 gene_id:1299|Hs108|chr20 ( 684) 1810 145.7 4.2e-34 CCDS450.1 COL9A2 gene_id:1298|Hs108|chr1 ( 689) 1750 141.4 8.3e-33 CCDS47447.1 COL9A1 gene_id:1297|Hs108|chr6 ( 678) 1739 140.6 1.4e-32 CCDS4971.1 COL9A1 gene_id:1297|Hs108|chr6 ( 921) 1734 140.4 2.2e-32 CCDS42971.1 COL18A1 gene_id:80781|Hs108|chr21 (1339) 1725 140.0 4.2e-32 CCDS42972.1 COL18A1 gene_id:80781|Hs108|chr21 (1519) 1725 140.1 4.5e-32 CCDS77643.1 COL18A1 gene_id:80781|Hs108|chr21 (1754) 1725 140.2 4.8e-32 CCDS43553.1 COL28A1 gene_id:340267|Hs108|chr7 (1125) 1456 120.7 2.3e-26 CCDS58922.1 COL25A1 gene_id:84570|Hs108|chr4 ( 645) 1390 115.6 4.4e-25 CCDS7554.1 COL17A1 gene_id:1308|Hs108|chr10 (1497) 1378 115.3 1.3e-24 CCDS83099.1 COL21A1 gene_id:81578|Hs108|chr6 ( 954) 1272 107.5 1.9e-22 CCDS55025.1 COL21A1 gene_id:81578|Hs108|chr6 ( 957) 1272 107.5 1.9e-22 CCDS41907.1 COL4A2 gene_id:1284|Hs108|chr13 (1712) 1202 102.8 8.5e-21 CCDS44419.1 COL13A1 gene_id:1305|Hs108|chr10 ( 717) 1182 100.8 1.4e-20 CCDS76010.1 COL4A6 gene_id:1288|Hs108|chrX (1707) 1189 101.9 1.6e-20 CCDS44427.2 COL13A1 gene_id:1305|Hs108|chr10 ( 645) 1175 100.3 1.9e-20 CCDS44424.2 COL13A1 gene_id:1305|Hs108|chr10 ( 695) 1175 100.3 2e-20 CCDS44425.2 COL13A1 gene_id:1305|Hs108|chr10 ( 686) 1162 99.4 3.7e-20 CCDS35081.1 COL15A1 gene_id:1306|Hs108|chr9 (1388) 1166 100.1 4.5e-20 CCDS4436.1 COL23A1 gene_id:91522|Hs108|chr5 ( 540) 1141 97.7 9.1e-20 CCDS44423.2 COL13A1 gene_id:1305|Hs108|chr10 ( 668) 1078 93.4 2.3e-18 CCDS76649.1 COL4A1 gene_id:1282|Hs108|chr13 ( 519) 1071 92.7 2.9e-18 >>CCDS34682.1 COL1A2 gene_id:1278|Hs108|chr7 (1366 aa) initn: 9990 init1: 9990 opt: 9990 Z-score: 3882.0 bits: 730.7 E(32554): 6.6e-210 Smith-Waterman score: 9990; 99.9% identity (99.9% similar) in 1366 aa overlap (1-1366:1-1366) 10 20 30 40 50 60 pF1KB4 MLSFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRGERGPPGPPGRDGEDGPTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 MLSFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRGERGPPGPPGRDGEDGPTG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 PPGPPGPPGPPGLGGNFAAQYDGKGVGLGPGPMGLMGPRGPPGAAGAPGPQGFQGPAGEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 PPGPPGPPGPPGLGGNFAAQYDGKGVGLGPGPMGLMGPRGPPGAAGAPGPQGFQGPAGEP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 GEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 GHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARGSDGSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARGSDGSV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 GPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEVGLPGLSGPVGPPGNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEVGLPGLSGPVGPPGNP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 GANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGLVGEPGPAGSKGESGNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGLVGEPGPAGSKGESGNK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 GEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPGPPGLRGSPGSRGLPGADGRAGVMGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPGPPGLRGSPGSRGLPGADGRAGVMGPP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 GSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAGKEGPVGLPGIDGRPGPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAGKEGPVGLPGIDGRPGPI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 GPAGARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GPAGARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB4 GGKGEQGPAGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPAGPRGERGPPGESGAA :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GGKGEQGPPGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPAGPRGERGPPGESGAA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB4 GPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGTAGPSGPSGLPGERGAAGIPGGKGEKGEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGTAGPSGPSGLPGERGAAGIPGGKGEKGEP 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB4 GLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSPGERGEVGPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSPGERGEVGPA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB4 GPNGFAGPAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GPNGFAGPAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDG 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB4 GPPGMTGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQGPVGRTGEVGAVGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GPPGMTGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQGPVGRTGEVGAVGPP 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB4 GFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIA 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB4 GPPGARGPPGAVGSPGVNGAPGEAGRDGNPGNDGPPGRDGQPGHKGERGYPGNIGPVGAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GPPGARGPPGAVGSPGVNGAPGEAGRDGNPGNDGPPGRDGQPGHKGERGYPGNIGPVGAA 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB4 GAPGPHGPVGPAGKHGNRGETGPSGPVGPAGAVGPRGPSGPQGIRGDKGEPGEKGPRGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GAPGPHGPVGPAGKHGNRGETGPSGPVGPAGAVGPRGPSGPQGIRGDKGEPGEKGPRGLP 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB4 GLKGHNGLQGLPGIAGHHGDQGAPGSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GLKGHNGLQGLPGIAGHHGDQGAPGSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIR 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB4 GPQGHQGPAGPPGPPGPPGPPGVSGGGYDFGYDGDFYRADQPRSAPSLRPKDYEVDATLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 GPQGHQGPAGPPGPPGPPGPPGVSGGGYDFGYDGDFYRADQPRSAPSLRPKDYEVDATLK 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KB4 SLNNQIETLLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQGCTMDAIKVYCDFSTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 SLNNQIETLLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQGCTMDAIKVYCDFSTG 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KB4 ETCIRAQPENIPAKNWYRSSKDKKHVWLGETINAGSQFEYNVEGVTSKEMATQLAFMRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 ETCIRAQPENIPAKNWYRSSKDKKHVWLGETINAGSQFEYNVEGVTSKEMATQLAFMRLL 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KB4 ANYASQNITYHCKNSIAYMDEETGNLKKAVILQGSNDVELVAEGNSRFTYTVLVDGCSKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 ANYASQNITYHCKNSIAYMDEETGNLKKAVILQGSNDVELVAEGNSRFTYTVLVDGCSKK 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 pF1KB4 TNEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFFVDIGPVCFK :::::::::::::::::::::::::::::::::::::::::::::: CCDS34 TNEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFFVDIGPVCFK 1330 1340 1350 1360 >>CCDS11561.1 COL1A1 gene_id:1277|Hs108|chr17 (1464 aa) initn: 11451 init1: 5207 opt: 5741 Z-score: 2240.6 bits: 427.1 E(32554): 1.8e-118 Smith-Waterman score: 6478; 64.3% identity (77.3% similar) in 1363 aa overlap (26-1365:105-1463) 10 20 30 40 50 pF1KB4 MLSFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRGERGPPGPPGRDG- :: : .:: :: :::: ::: ::::::: CCDS11 CDETKNCPGAEVPEGECCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGI 80 90 100 110 120 130 60 70 80 90 100 pF1KB4 --EDGPTGPPGPPGPPGPPGLGGNFAAQ----YDGKGVGLG---PGPMGLMGPRGPPGAA . : ::::::::::::::::::: : :: :..: : ::::: :::: :: CCDS11 PGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTG-GISVPGPMGPSGPRGLPGPP 140 150 160 170 180 190 110 120 130 140 150 160 pF1KB4 GAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGAR ::::::::::: ::::::: .:: : ::: ::::: :.::. :::::::::: :::::: CCDS11 GAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGAR 200 210 220 230 240 250 170 180 190 200 210 220 pF1KB4 GFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRV :.::: ::::.:: :: .:::: ::. : : :::::.:::::.::: : ::::::::: CCDS11 GLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRP 260 270 280 290 300 310 230 240 250 260 270 280 pF1KB4 GAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEV ::::::::::.::..: .:: :: : ::::::::: : ::: : : : :: : ::: CCDS11 GAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEP 320 330 340 350 360 370 290 300 310 320 330 340 pF1KB4 GLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGLV : :: .: .:: :::::.: ::::: : ::.:::::.:: :: :: : .: : .: CCDS11 GPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNS 380 390 400 410 420 430 350 360 370 380 390 400 pF1KB4 GEPGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPGPPGLRGSPGSR :::: ::::..: ::::: .: ::::::.::::::: :: : .: ::::: ::.:::: CCDS11 GEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSR 440 450 460 470 480 490 410 420 430 440 450 460 pF1KB4 GLPGADGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAGKE :.::::: :: :: : ::. :::: .: :.:::::: :: : .:: ::::. :: :: CCDS11 GFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKT 500 510 520 530 540 550 470 480 490 500 510 520 pF1KB4 GPVGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPGPD :: : : :::::: :: ::::. : .::::::: .:.::: :..: : :: : : : CCDS11 GPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKD 560 570 580 590 600 610 530 540 550 560 570 580 pF1KB4 GNNGAQGPPGPQGVQGGKGEQGPAGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPA :. :::::::: : : .::::::: :::::::::.:: ::.:::::.:. :..: :::. CCDS11 GEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPS 620 630 640 650 660 670 590 600 610 620 630 640 pF1KB4 GPRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGTAGPSGPSGLPGER : ::::: ::: :. :: :: : :: .: :: :: ::. :. :: :. : : .:.:::: CCDS11 GARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGER 680 690 700 710 720 730 650 660 670 680 690 700 pF1KB4 GAAGIPGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPA ::::.:: ::..:. : .: :.::.::.:: : .: :::::: ::.::.: .:::::. CCDS11 GAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPT 740 750 760 770 780 790 710 720 730 740 750 760 pF1KB4 GPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPA : ::.::.::: :: :: ::::: :: :::::::: : : ::. : ::.::.: :: CCDS11 GARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPI 800 810 820 830 840 850 770 780 790 800 810 820 pF1KB4 GPNGPPGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQ : : :: :.::..:::: :::::::::.::::::: .::::::::::::: .::::. CCDS11 GNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGET 860 870 880 890 900 910 830 840 850 860 870 880 pF1KB4 GPVGRTGEVGAVGPPGFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLP ::.:: :::: :::: ::::: : : :: ::::::::. : :..::::.:::::.: CCDS11 GPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFP 920 930 940 950 960 970 890 900 910 920 930 940 pF1KB4 GVAGAVGEPGPLGIAGPPGARGPPGAVGSPGVNGAPGEAGRDGNPGNDGPPGRDGQPGHK :. : :::: : .: : ::::: .: ::. : :::.::.: :: .: :::::.:: : CCDS11 GLPGPSGEPGKQGPSGASGERGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSPGAK 980 990 1000 1010 1020 1030 950 960 970 980 990 1000 pF1KB4 GERGYPGNIGPVGAAGAPGPHGPVGPAGKHGNRGETGPSGPVGPAGAVGPRGPSGPQGIR :.:: : :: :: :::: :::::::: :.::::::.::.::.: :: :::.:::: : CCDS11 GDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARGPAGPQGPR 1040 1050 1060 1070 1080 1090 1010 1020 1030 1040 1050 1060 pF1KB4 GDKGEPGEKGPRGLPGLKGHNGLQGLPGIAGHHGDQGAPGSVGPAGPRGPAGPSGPAGKD ::::: ::.: ::. : .: .:::: :: : :.:: :. :::::::: : .: ::: CCDS11 GDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPRGPPGSAGAPGKD 1100 1110 1120 1130 1140 1150 1070 1080 1090 1100 1110 pF1KB4 GRTGHPGTVGPAGIRGPQGHQGPAGPPGPPGPPGPPGVSGGGYDFGY----------DGD : .: :: .:: : :: : ::.::::::::::::: ..:.::.. :: CCDS11 GLNGLPGPIGPPGPRGRTGDAGPVGPPGPPGPPGPPGPPSAGFDFSFLPQPPQEKAHDGG 1160 1170 1180 1190 1200 1210 1120 1130 1140 1150 1160 1170 pF1KB4 -FYRADQPRSAPSLRPKDYEVDATLKSLNNQIETLLTPEGSRKNPARTCRDLRLSHPEWS .:::: .: .: .: :::.:::::..:::.. .:::::::::::::::.. : .:. CCDS11 RYYRAD---DANVVRDRDLEVDTTLKSLSQQIENIRSPEGSRKNPARTCRDLKMCHSDWK 1220 1230 1240 1250 1260 1270 1180 1190 1200 1210 1220 1230 pF1KB4 SGYYWIDPNQGCTMDAIKVYCDFSTGETCIRAQPENIPAKNWY--RSSKDKKHVWLGETI :: :::::::::..:::::.:.. :::::. .. :::: .. :::.:::.::.. CCDS11 SGEYWIDPNQGCNLDAIKVFCNMETGETCVYPTQPSVAQKNWYISKNPKDKRHVWFGESM 1280 1290 1300 1310 1320 1330 1240 1250 1260 1270 1280 1290 pF1KB4 NAGSQFEYNVEGVTSKEMATQLAFMRLLANYASQNITYHCKNSIAYMDEETGNLKKAVIL . : ::::. .: ..: ::.:.::... ::::::::::::.::::..:::::::..: CCDS11 TDGFQFEYGGQGSDPADVAIQLTFLRLMSTEASQNITYHCKNSVAYMDQQTGNLKKALLL 1340 1350 1360 1370 1380 1390 1300 1310 1320 1330 1340 1350 pF1KB4 QGSNDVELVAEGNSRFTYTVLVDGCSKKTNEWGKTIIEYKTNKPSRLPFLDIAPLDIGGA ::::..:. :::::::::.: ::::...:. ::::.:::::.: ::::..:.::::.:. CCDS11 QGSNEIEIRAEGNSRFTYSVTVDGCTSHTGAWGKTVIEYKTTKTSRLPIIDVAPLDVGAP 1400 1410 1420 1430 1440 1450 1360 pF1KB4 DQEFFVDIGPVCFK :::: :.::::: CCDS11 DQEFGFDVGPVCFL 1460 >>CCDS8759.1 COL2A1 gene_id:1280|Hs108|chr12 (1418 aa) initn: 5023 init1: 5023 opt: 5238 Z-score: 2046.5 bits: 391.1 E(32554): 1.1e-107 Smith-Waterman score: 6447; 64.9% identity (77.3% similar) in 1358 aa overlap (32-1365:62-1417) 10 20 30 40 50 pF1KB4 LSFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRGERGPPGPPGRDGEDG-P-- .:: :::: .::.: ::: ::::: : : CCDS87 GPKGQKGEPGDIKDIVGPKGPPGPQGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPGTPGN 40 50 60 70 80 90 60 70 80 90 100 110 pF1KB4 TGPPGPPGPPGPPGLGGNFAAQ----YDGK--GVGLG--PGPMGLMGPRGPPGAAGAPGP ::::::::::::::::::::: .: : :. :: :::: :::::::: :::::: CCDS87 PGPPGPPGPPGPPGLGGNFAAQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPAGAPGP 100 110 120 130 140 150 120 130 140 150 160 170 pF1KB4 QGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGT ::::: ::::::: .:: : ::: ::::: :.::. ::::. :::: ::::::::::: CCDS87 QGFQGNPGEPGEPGVSGPMGPRGPPGPPGKPGDDGEAGKPGKAGERGPPGPQGARGFPGT 160 170 180 190 200 210 180 190 200 210 220 230 pF1KB4 PGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGP ::::: :: ::. :::: ::. :::::::: :.:::::.:: : :::::::::.: : CCDS87 PGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGA 220 230 240 250 260 270 240 250 260 270 280 290 pF1KB4 AGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEVGLPGL :::::.::. ::.:: ::.: :: :::::::: ::: : .: :: : ::::: : :: CCDS87 AGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGS 280 290 300 310 320 330 300 310 320 330 340 350 pF1KB4 SGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGLVGEPGP ::.: ::::..:. ::::.:: ::.:::::.::::: ::: ::.: : .: .:::: CCDS87 PGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGI 340 350 360 370 380 390 360 370 380 390 400 410 pF1KB4 AGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPGPPGLRGSPGSRGLPGA :: :::.: ::::: ::::: :::.::::::: :: :..:: :::: ::.::.::.:: CCDS87 AGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQ 400 410 420 430 440 450 420 430 440 450 460 470 pF1KB4 DGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAGKEGPVGL :: :: : :: :: :: :: .: ::: :::::::: : ::: : ::. :: :: :: : CCDS87 DGLAGPKGAPGERGPSGLAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGA 460 470 480 490 500 510 480 490 500 510 520 530 pF1KB4 PGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPGPDGNNGA :: :::::: :: ::::.:: .::::::: .:.::: :.:: : : :: :: ::..:: CCDS87 PGEDGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGA 520 530 540 550 560 570 540 550 560 570 580 590 pF1KB4 QGPPGPQGVQGGKGEQGPAGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPAGPRGE ::::: : : .:::: :: :::::::: :: :: ::::..:. :: : :: .::::: CCDS87 AGPPGPAGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGE 580 590 600 610 620 630 600 610 620 630 640 650 pF1KB4 RGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGTAGPSGPSGLPGERGAAGI :: ::: :. : : : :: : :: :: :: : .: :. :: : .:.::::::::: CCDS87 RGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGI 640 650 660 670 680 690 660 670 680 690 700 710 pF1KB4 PGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGS : ::..:. : .: : ::.::.:: : .: ::::::.:..::.: :::: :: ::. CCDS87 AGPKGDRGDVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGA 700 710 720 730 740 750 720 730 740 750 760 770 pF1KB4 PGERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGP ::::::.:: :: ::::: :: ::::::::.: : ::. :. :: :: :: :: ::.: CCDS87 PGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGV 760 770 780 790 800 810 780 790 800 810 820 830 pF1KB4 PGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQGPVGR :: :.:: :::: :::::::::.:::: .: ::::::::.::.: .: :::.:: :: CCDS87 TGPKGARGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGR 820 830 840 850 860 870 840 850 860 870 880 890 pF1KB4 TGEVGAVGPPGFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGA .:: : :: : :::: :. : .: : :::::: : ::.::::.:::::.::. : CCDS87 AGEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGP 880 890 900 910 920 930 900 910 920 930 940 950 pF1KB4 VGEPGPLGIAGPPGARGPPGAVGSPGVNGAPGEAGRDGNPGNDGPPGRDGQPGHKGERGY :::: : : : ::::: :: ::..: :: ::.:.:: :::::::: : ::.:: CCDS87 SGEPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGE 940 950 960 970 980 990 960 970 980 990 1000 1010 pF1KB4 PGNIGPVGAAGAPGPHGPVGPAGKHGNRGETGPSGPVGPAGAVGPRGPSGPQGIRGDKGE : .: :: : :: ::.::.::.:.:::.: .::.::.: .: :: .:::: :::::: CCDS87 TGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGE 1000 1010 1020 1030 1040 1050 1020 1030 1040 1050 1060 1070 pF1KB4 PGEKGPRGLPGLKGHNGLQGLPGIAGHHGDQGAPGSVGPAGPRGPAGPSGPAGKDGRTGH :: : ::: : .: .::::::: : ::::: : .::.::::: :: ::.:::: .: CCDS87 AGEPGERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGI 1060 1070 1080 1090 1100 1110 1080 1090 1100 1110 pF1KB4 PGTVGPAGIRGPQGHQGPAGPPGPPGPPGPPGVSGGGYDF-----------GYDG-DFYR :: .:: : :: .:. ::::::: :::::::: : : :. : : ...: CCDS87 PGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLGPREKGPDPLQYMR 1120 1130 1140 1150 1160 1170 1120 1130 1140 1150 1160 1170 pF1KB4 ADQPRSAPSLRPKDYEVDATLKSLNNQIETLLTPEGSRKNPARTCRDLRLSHPEWSSGYY ::: .: .:: .: ::::::::::::::.. .:::::::::::::::.: ::::.:: : CCDS87 ADQ--AAGGLRQHDAEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLKLCHPEWKSGDY 1180 1190 1200 1210 1220 1180 1190 1200 1210 1220 1230 pF1KB4 WIDPNQGCTMDAIKVYCDFSTGETCIRAQPENIPAKNWYRS-SKDKKHVWLGETINAGSQ :::::::::.::.::.:.. :::::. .: :.: :::. : ::.:::.:.:::::.: . CCDS87 WIDPNQGCTLDAMKVFCNMETGETCVYPNPANVPKKNWWSSKSKEKKHIWFGETINGGFH 1230 1240 1250 1260 1270 1280 1240 1250 1260 1270 1280 1290 pF1KB4 FEYNVEGVTSKEMATQLAFMRLLANYASQNITYHCKNSIAYMDEETGNLKKAVILQGSND : :. .... . .:..:.:::.. .::::::::::::::.:: .::::::...::::: CCDS87 FSYGDDNLAPNTANVQMTFLRLLSTEGSQNITYHCKNSIAYLDEAAGNLKKALLIQGSND 1290 1300 1310 1320 1330 1340 1300 1310 1320 1330 1340 1350 pF1KB4 VELVAEGNSRFTYTVLVDGCSKKTNEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFF ::. ::::::::::.: :::.:.:..::::.:::...: ::::..::::.:::: .::: CCDS87 VEIRAEGNSRFTYTALKDGCTKHTGKWGKTVIEYRSQKTSRLPIIDIAPMDIGGPEQEFG 1350 1360 1370 1380 1390 1400 1360 pF1KB4 VDIGPVCFK :::::::: CCDS87 VDIGPVCFL 1410 >>CCDS41778.1 COL2A1 gene_id:1280|Hs108|chr12 (1487 aa) initn: 5023 init1: 5023 opt: 5238 Z-score: 2046.3 bits: 391.2 E(32554): 1.2e-107 Smith-Waterman score: 6447; 64.9% identity (77.3% similar) in 1358 aa overlap (32-1365:131-1486) 10 20 30 40 50 pF1KB4 LSFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRGERGPPGPPGRDGEDG-P-- .:: :::: .::.: ::: ::::: : : CCDS41 GPKGQKGEPGDIKDIVGPKGPPGPQGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPGTPGN 110 120 130 140 150 160 60 70 80 90 100 110 pF1KB4 TGPPGPPGPPGPPGLGGNFAAQ----YDGK--GVGLG--PGPMGLMGPRGPPGAAGAPGP ::::::::::::::::::::: .: : :. :: :::: :::::::: :::::: CCDS41 PGPPGPPGPPGPPGLGGNFAAQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPAGAPGP 170 180 190 200 210 220 120 130 140 150 160 170 pF1KB4 QGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGT ::::: ::::::: .:: : ::: ::::: :.::. ::::. :::: ::::::::::: CCDS41 QGFQGNPGEPGEPGVSGPMGPRGPPGPPGKPGDDGEAGKPGKAGERGPPGPQGARGFPGT 230 240 250 260 270 280 180 190 200 210 220 230 pF1KB4 PGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGP ::::: :: ::. :::: ::. :::::::: :.:::::.:: : :::::::::.: : CCDS41 PGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGA 290 300 310 320 330 340 240 250 260 270 280 290 pF1KB4 AGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEVGLPGL :::::.::. ::.:: ::.: :: :::::::: ::: : .: :: : ::::: : :: CCDS41 AGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGS 350 360 370 380 390 400 300 310 320 330 340 350 pF1KB4 SGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGLVGEPGP ::.: ::::..:. ::::.:: ::.:::::.::::: ::: ::.: : .: .:::: CCDS41 PGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGI 410 420 430 440 450 460 360 370 380 390 400 410 pF1KB4 AGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPGPPGLRGSPGSRGLPGA :: :::.: ::::: ::::: :::.::::::: :: :..:: :::: ::.::.::.:: CCDS41 AGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQ 470 480 490 500 510 520 420 430 440 450 460 470 pF1KB4 DGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAGKEGPVGL :: :: : :: :: :: :: .: ::: :::::::: : ::: : ::. :: :: :: : CCDS41 DGLAGPKGAPGERGPSGLAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGA 530 540 550 560 570 580 480 490 500 510 520 530 pF1KB4 PGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPGPDGNNGA :: :::::: :: ::::.:: .::::::: .:.::: :.:: : : :: :: ::..:: CCDS41 PGEDGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGA 590 600 610 620 630 640 540 550 560 570 580 590 pF1KB4 QGPPGPQGVQGGKGEQGPAGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPAGPRGE ::::: : : .:::: :: :::::::: :: :: ::::..:. :: : :: .::::: CCDS41 AGPPGPAGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGE 650 660 670 680 690 700 600 610 620 630 640 650 pF1KB4 RGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGTAGPSGPSGLPGERGAAGI :: ::: :. : : : :: : :: :: :: : .: :. :: : .:.::::::::: CCDS41 RGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGI 710 720 730 740 750 760 660 670 680 690 700 710 pF1KB4 PGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGS : ::..:. : .: : ::.::.:: : .: ::::::.:..::.: :::: :: ::. CCDS41 AGPKGDRGDVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGA 770 780 790 800 810 820 720 730 740 750 760 770 pF1KB4 PGERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGP ::::::.:: :: ::::: :: ::::::::.: : ::. :. :: :: :: :: ::.: CCDS41 PGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGV 830 840 850 860 870 880 780 790 800 810 820 830 pF1KB4 PGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQGPVGR :: :.:: :::: :::::::::.:::: .: ::::::::.::.: .: :::.:: :: CCDS41 TGPKGARGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGR 890 900 910 920 930 940 840 850 860 870 880 890 pF1KB4 TGEVGAVGPPGFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGA .:: : :: : :::: :. : .: : :::::: : ::.::::.:::::.::. : CCDS41 AGEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGP 950 960 970 980 990 1000 900 910 920 930 940 950 pF1KB4 VGEPGPLGIAGPPGARGPPGAVGSPGVNGAPGEAGRDGNPGNDGPPGRDGQPGHKGERGY :::: : : : ::::: :: ::..: :: ::.:.:: :::::::: : ::.:: CCDS41 SGEPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGE 1010 1020 1030 1040 1050 1060 960 970 980 990 1000 1010 pF1KB4 PGNIGPVGAAGAPGPHGPVGPAGKHGNRGETGPSGPVGPAGAVGPRGPSGPQGIRGDKGE : .: :: : :: ::.::.::.:.:::.: .::.::.: .: :: .:::: :::::: CCDS41 TGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGE 1070 1080 1090 1100 1110 1120 1020 1030 1040 1050 1060 1070 pF1KB4 PGEKGPRGLPGLKGHNGLQGLPGIAGHHGDQGAPGSVGPAGPRGPAGPSGPAGKDGRTGH :: : ::: : .: .::::::: : ::::: : .::.::::: :: ::.:::: .: CCDS41 AGEPGERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGI 1130 1140 1150 1160 1170 1180 1080 1090 1100 1110 pF1KB4 PGTVGPAGIRGPQGHQGPAGPPGPPGPPGPPGVSGGGYDF-----------GYDG-DFYR :: .:: : :: .:. ::::::: :::::::: : : :. : : ...: CCDS41 PGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLGPREKGPDPLQYMR 1190 1200 1210 1220 1230 1240 1120 1130 1140 1150 1160 1170 pF1KB4 ADQPRSAPSLRPKDYEVDATLKSLNNQIETLLTPEGSRKNPARTCRDLRLSHPEWSSGYY ::: .: .:: .: ::::::::::::::.. .:::::::::::::::.: ::::.:: : CCDS41 ADQ--AAGGLRQHDAEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLKLCHPEWKSGDY 1250 1260 1270 1280 1290 1180 1190 1200 1210 1220 1230 pF1KB4 WIDPNQGCTMDAIKVYCDFSTGETCIRAQPENIPAKNWYRS-SKDKKHVWLGETINAGSQ :::::::::.::.::.:.. :::::. .: :.: :::. : ::.:::.:.:::::.: . CCDS41 WIDPNQGCTLDAMKVFCNMETGETCVYPNPANVPKKNWWSSKSKEKKHIWFGETINGGFH 1300 1310 1320 1330 1340 1350 1240 1250 1260 1270 1280 1290 pF1KB4 FEYNVEGVTSKEMATQLAFMRLLANYASQNITYHCKNSIAYMDEETGNLKKAVILQGSND : :. .... . .:..:.:::.. .::::::::::::::.:: .::::::...::::: CCDS41 FSYGDDNLAPNTANVQMTFLRLLSTEGSQNITYHCKNSIAYLDEAAGNLKKALLIQGSND 1360 1370 1380 1390 1400 1410 1300 1310 1320 1330 1340 1350 pF1KB4 VELVAEGNSRFTYTVLVDGCSKKTNEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFF ::. ::::::::::.: :::.:.:..::::.:::...: ::::..::::.:::: .::: CCDS41 VEIRAEGNSRFTYTALKDGCTKHTGKWGKTVIEYRSQKTSRLPIIDIAPMDIGGPEQEFG 1420 1430 1440 1450 1460 1470 1360 pF1KB4 VDIGPVCFK :::::::: CCDS41 VDIGPVCFL 1480 >>CCDS33350.1 COL5A2 gene_id:1290|Hs108|chr2 (1499 aa) initn: 8339 init1: 4432 opt: 4602 Z-score: 1800.6 bits: 345.7 E(32554): 5.7e-94 Smith-Waterman score: 5533; 56.9% identity (70.7% similar) in 1363 aa overlap (32-1365:140-1498) 10 20 30 40 50 60 pF1KB4 LSFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRGERGPPGPPGRDGEDGPTGP .:: :.:::.:. :: :: : ::: : : CCDS33 GRKGQKGEPGLVPVVTGIRGRPGPAGPPGSQGPRGERGPKGRPGPRGPQGIDGEPGVPGQ 110 120 130 140 150 160 70 80 90 100 pF1KB4 PGPPGPPG------PPGLGGNFAAQYDG----KG----VGLGPGPMGLMGPRGPPGAAGA :: ::::: : ::. :.::. : .: ::: :: .: .::::: : : CCDS33 PGAPGPPGHPSHPGPDGLSRPFSAQMAGLDEKSGLGSQVGLMPGSVGPVGPRGPQGLQGQ 170 180 190 200 210 220 110 120 130 140 150 160 pF1KB4 PGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGARGF : : :: ::::.:: :: :.::: ::::: ::::.::. : ::: : .: ::::: CCDS33 QGGAGPTGPPGEPGDPGPMGPIGSRGPEGPPGKPGEDGEPGRNGNPGEVGFAGSPGARGF 230 240 250 260 270 280 170 180 190 200 210 220 pF1KB4 PGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGA ::.:::::.:: :::.::.: ::. :::: ::: : : :. : : ::.::::::.: CCDS33 PGAPGLPGLKGHRGHKGLEGPKGEVGAPGSKGEAGPTGPMGAMGPLGPRGMPGERGRLGP 290 300 310 320 330 340 230 240 250 260 270 280 pF1KB4 PGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEVGL : : ::. : : :: ::.: : :::: :: ::: : .: :: :: : :::.: CCDS33 QGAPGQRGAHGMPGKPGPMGPLGIPGSSGFPGNPGMKGEAGPTGARGPEGPQGQRGETGP 350 360 370 380 390 400 290 300 310 320 330 340 pF1KB4 PGLSGPVGPPGNPGA---NGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGL :: ::: :: ::: .: :::: .: ::..: :: :: : ::: :..: : :: CCDS33 PG---PVGSPGLPGAIGTDGTPGAKGPTGSPGTSGPPGSAGPPGSPGPQGSTGPQGIRGQ 410 420 430 440 450 460 350 360 370 380 390 400 pF1KB4 VGEPGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPGPPGLRGSPGS :.:: : :::.: ::::: : ::: :: :::::::: :. :..::::: : ::.::. CCDS33 PGDPGVPGFKGEAGPKGEPGPHGIQGPIGPPGEEGKRGPRGDPGTVGPPGPVGERGAPGN 470 480 490 500 510 520 410 420 430 440 450 460 pF1KB4 RGLPGADGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAGK ::.::.:: : : : :: : .: .: .:: :::::::: : ::: :.:: :: :: CCDS33 RGFPGSDGLPGPKGAQGERGPVGSSGPKGSQGDPGRPGEPGLPGARGLTGNPGVQGPEGK 530 540 550 560 570 580 470 480 490 500 510 520 pF1KB4 EGPVGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPGP ::.: :: :::::: : : ::.::..:.::::: .::::: :. :.::. : ::::: CCDS33 LGPLGAPGEDGRPGPPGSIGIRGQPGSMGLPGPKGSSGDPGKPGEAGNAGVPGQRGAPGK 590 600 610 620 630 640 530 540 550 560 570 580 pF1KB4 DGNNGAQGPPGPQGVQGGKGEQGPAGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGP ::. : .:: :: :. : .::::: :: :::::::: :: :: ::::..:. :. : :: CCDS33 DGEVGPSGPVGPPGLAGERGEQGPPGPTGFQGLPGPPGPPGEGGKPGDQGVPGDPGAVGP 650 660 670 680 690 700 590 600 610 620 630 640 pF1KB4 AGPRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGTAGPSGPSGLPGE ::::::: ::: : : :: : .: .: :::: :: :: :. : .:: : .:.::: CCDS33 LGPRGERGNPGERGEPGITGLPGEKGMAGGHGPDGPKGSPGPSGTPGDTGPPGLQGMPGE 710 720 730 740 750 760 650 660 670 680 690 700 pF1KB4 RGAAGIPGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGP :: :: :: ::..: : .: :. : ::::: :: .: ::::: ::..:: : : .:: CCDS33 RGIAGTPGPKGDRGGIGEKGAEGTAGNDGARGLPGPLGPPGPAGPTGEKGEPGPRGLVGP 770 780 790 800 810 820 710 720 730 740 750 760 pF1KB4 AGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGP : ::.:: ::: ::.: ::::: : ::::.::: : : ::. : :: : .:. :: CCDS33 PGSRGNPGSRGENGPTGAVGFAGPQGPDGQPGVKGEPGEPGQKGDAGSPGPQGLAGSPGP 830 840 850 860 870 880 770 780 790 800 810 820 pF1KB4 AGPNGPPGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGD :::: :: :.:: :::: :::::.:::.:::::.: :: :: : :::: : ::: CCDS33 HGPNGVPGLKGGRGTQGPPGATGFPGSAGRVGPPGPAGAPGPAGPLGEPGKEGPPGLRGD 890 900 910 920 930 940 830 840 850 860 870 880 pF1KB4 QGPVGRTGEVGAVGPPGFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGL : ::.:. : .:::: :.:: :: : :: : ::: : : ::.:.::.:::::. CCDS33 PGSHGRVGDRGPAGPPGGPGDKGDPGEDGQPGPDGPPGPAGTTGQRGIVGMPGQRGERGM 950 960 970 980 990 1000 890 900 910 920 930 940 pF1KB4 PGVAGAVGEPGPLGIAGPPGARGPPGAVGSPGVNGAPGEAGRDGNPGNDGPPGRDGQPGH ::. : .: :: .: .: : .:::: :: :: :: :: : .: :::: ::::: :. CCDS33 PGLPGPAGTPGKVGPTGATGDKGPPGPVGPPGSNGPVGEPGPEGPAGNDGTPGRDGAVGE 1010 1020 1030 1040 1050 1060 950 960 970 980 990 1000 pF1KB4 KGERGYPGNIGPVGAAGAPGPHGPVGPAGKHGNRGETGPSGPVGPAGAVGPRGPSGPQGI .:.:: :: : :. :::: :::: : :.::. : ::.:: : .: :: :::: CCDS33 RGDRGDPGPAGLPGSQGAPGTPGPVGAPGDAGQRGDPGSRGPIGPPGRAGKRGLPGPQGP 1070 1080 1090 1100 1110 1120 1010 1020 1030 1040 1050 1060 pF1KB4 RGDKGEPGEKGPRGLPGLKGHNGLQGLPGIAGHHGDQGAPGSVGPAGPRGPAGPSGPAGK :::::. :..: :: : .: .::::::: : .:.::. : :: ::::: :: ::.:: CCDS33 RGDKGDHGDRGDRGQKGHRGFTGLQGLPGPPGPNGEQGSAGIPGPFGPRGPPGPVGPSGK 1130 1140 1150 1160 1170 1180 1070 1080 1090 1100 1110 pF1KB4 DGRTGHPGTVGPAGIRGPQGHQGPAGPPGPPGPPGPPGVSG----------GGYDFGYDG .: : : .:: :.:: :. :: :::: :::::::: : : :: .. CCDS33 EGNPGPLGPIGPPGVRGSVGEAGPEGPPGEPGPPGPPGPPGHLTAALGDIMGHYDESMPD 1190 1200 1210 1220 1230 1240 1120 1130 1140 1150 1160 1170 pF1KB4 DFYRADQPRSAPSLRPK-DYEVDATLKSLNNQIETLLTPEGSRKNPARTCRDLRLSHPEW . . . ..::. . : : : ::::::..::::. .:.::.:.::::: ::.: : CCDS33 PLPEFTEDQAAPDDKNKTDPGVHATLKSLSSQIETMRSPDGSKKHPARTCDDLKLCHSAK 1250 1260 1270 1280 1290 1300 1180 1190 1200 1210 1220 1230 pF1KB4 SSGYYWIDPNQGCTMDAIKVYCDFSTGETCIRAQPENIPAKNWYRS-SKDKKHVWLGETI .:: :::::::: . :::::::.. :::::: :.: ..: :.:. : : :.: :: : . CCDS33 QSGEYWIDPNQGSVEDAIKVYCNMETGETCISANPSSVPRKTWWASKSPDNKPVWYGLDM 1310 1320 1330 1340 1350 1360 1240 1250 1260 1270 1280 1290 pF1KB4 NAGSQFEYNVEGVTSKEMATQLAFMRLLANYASQNITYHCKNSIAYMDEETGNLKKAVIL : :::: :. . . . ::..:.:::.. ::::::: ::::..:::... ::::::.: CCDS33 NRGSQFAYG-DHQSPNTAITQMTFLRLLSKEASQNITYICKNSVGYMDDQAKNLKKAVVL 1370 1380 1390 1400 1410 1420 1300 1310 1320 1330 1340 1350 pF1KB4 QGSNDVELVAEGNSRFTYTVLVDGCSKKTNEWGKTIIEYKTNKPSRLPFLDIAPLDIGGA .:.::... :::: :: : :: : :::.... :::..::.:.. .:::..:.::.:.::. CCDS33 KGANDLDIKAEGNIRFRYIVLQDTCSKRNGNVGKTVFEYRTQNVARLPIIDLAPVDVGGT 1430 1440 1450 1460 1470 1480 1360 pF1KB4 DQEFFVDIGPVCFK :::: :.:::::: CCDS33 DQEFGVEIGPVCFV 1490 >>CCDS2297.1 COL3A1 gene_id:1281|Hs108|chr2 (1466 aa) initn: 7054 init1: 4214 opt: 4344 Z-score: 1701.0 bits: 327.3 E(32554): 2e-88 Smith-Waterman score: 5477; 56.3% identity (70.0% similar) in 1388 aa overlap (18-1365:84-1465) 10 20 30 40 pF1KB4 MLSFVDTRTLLLLAVTLCLATCQSLQEETVRK-GPAGDRGPRGERGP : :.: . .: . : .::.:. :: CCDS22 VCDSGSVLCDDIICDDQELDCPNPEIPFGECCAVCPQPPTAPTRPPNGQGPQGPKGDPGP 60 70 80 90 100 110 50 60 70 80 90 pF1KB4 PGPPGRDGEDGPTGPPGPPGPPGPPGL-----GG--NFAAQYDG----KGVGLG-----P :: :::.:. : : :: :: :::::. : :.. :::. .::..: : CCDS22 PGIPGRNGDPGIPGQPGSPGSPGPPGICESCPTGPQNYSPQYDSYDVKSGVAVGGLAGYP 120 130 140 150 160 170 100 110 120 130 140 pF1KB4 GPMGLMGPRGPPGAAG---APGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHP :: : :: ::::..: .:: :.::: ::::. : .:: : : :: : ::.::. CCDS22 GPAGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGPAGKDGES 180 190 200 210 220 230 150 160 170 180 190 200 pF1KB4 GKPGRPGERGVVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGEN :.::::::::. :: : .: : ::.::.:: :: .: .: ::. ::::.::: : :::: CCDS22 GRPGRPGERGLPGPPGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGEN 240 250 260 270 280 290 210 220 230 240 250 260 pF1KB4 GTPGQTGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEI :.:: : :: :::::: : :: :::::.::. : : :: : : ::::.:: :::. CCDS22 GAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEV 300 310 320 330 340 350 270 280 290 300 310 320 pF1KB4 GAVGNAGPAGPAGPRGEVGLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPR : .:. : : : ::: : : .: :::: :: :: :.:: : :. ::::: : : CCDS22 GPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPGINGSPGGKGEMGPAGIPGAPGLMGAR 360 370 380 390 400 410 330 340 350 360 370 380 pF1KB4 GIPGPVGAAGATGARGLVGEPGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEA : :::.:: :: : :: .:::: :.::: : .:: : :: : :: .::.:: : :: CCDS22 GPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGEP 420 430 440 450 460 470 390 400 410 420 430 440 pF1KB4 GSAGPPGPPGLRGSPGSRGLPGADGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGEPGLM :. : :: : ::.:: :: : .: : :: : ::: :::: :: :. :: : :: CCDS22 GANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPGGP 480 490 500 510 520 530 450 460 470 480 490 500 pF1KB4 GPRGLPGSPGNIGPAGKEGPVGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKN : ::.:::::. : :: :: : : .::::: ::.: ::.:: .::::::: : :::: CCDS22 GMRGMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKN 540 550 560 570 580 590 510 520 530 540 550 560 pF1KB4 GDKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPAGPPGFQGLPGPSGPAGEV :..: : : .: :: .:..: :::::: : : ::. :: :: :.::::: .:: :: CCDS22 GERGGPGGPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQGLQGLPGTGGPPGEN 600 610 620 630 640 650 570 580 590 600 610 620 pF1KB4 GKPGERGLHGEFGLPGPAGPRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVV ::::: : .:. : :: : .:. : ::: : : .: : :: .:::::.:.:: : CCDS22 GKPGEPGPKGDAGAPGAPGGKGDAGAPGERGPPGLAGAPGLRGGAGPPGPEGGKGAAGPP 660 670 680 690 700 710 630 640 650 660 670 680 pF1KB4 GAVGTAGPSGPSGLPGERGAAGIPGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPGPA : :.:: : .:.:::::. : :: ::.::::: : : ::.:: :: : .: :::: CCDS22 GPPGAAGTPGLQGMPGERGGLGSPGPKGDKGEPGGPGADGVPGKDGPRGPTGPIGPPGPA 720 730 740 750 760 770 690 700 710 720 730 740 pF1KB4 GATGDRGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKGPK : ::.::.:: : : ::::::::::::.:: :: :: : : :.::.:::::: : : CCDS22 GQPGDKGEGGAPGLPGIAGPRGSPGERGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEK 780 790 800 810 820 830 750 760 770 780 790 800 pF1KB4 GENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGPP ::.: : .:: :..::::: :: : : ::. : :: .::::: : :::: .: : CCDS22 GEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPGPPGSNG---NP 840 850 860 870 880 890 810 820 830 840 850 860 pF1KB4 GPPGPAGKEGLRGPRGDQGPVGRTGEVGAVGPPGFAGEKGPSGEAGTAGPPGTPGP---Q :::::.:. : :: : : .: : :. :: : ::. : .: :. ::::.::: CCDS22 GPPGPSGSPGKDGPPGPAGNTGAPGSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIA 900 910 920 930 940 950 870 880 890 900 910 920 pF1KB4 GLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIAGPPGARGPPGAVGSPGVNGAPGEA :. :: :. : :: : :: :: :. :: : : : : ::::: : ::. :. :: CCDS22 GITGARGLAGPPGMPGPRGSPGPQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEP 960 970 980 990 1000 1010 930 940 950 960 970 980 pF1KB4 GRDGNPGNDGPPGRDGQPGHKGERGYPGNIGPVGAAGAPGPHGPVGPAGKHGNRGETGPS :::::::.:: :::::.:: ::.:: :. : :: : ::: :::::::: :.:::.::. CCDS22 GRDGNPGSDGLPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPA 1020 1030 1040 1050 1060 1070 990 1000 1010 1020 1030 1040 pF1KB4 GPVGPAGAVGPRGPSGPQGIRGDKGEPGEKGPRGLPGLKGHNGLQGLPGIAGHHGDQGAP ::.: : .: :: :::: :::::: ::.: :. : .: : : :: : :.::: CCDS22 GPAGAPGPAGSRGAPGPQGPRGDKGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAI 1080 1090 1100 1110 1120 1130 1050 1060 1070 1080 1090 1100 pF1KB4 GSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIRGPQGHQGPAGPPG-P--PGPPGPP :: ::::::::.::::: :::: .:::: .:: : :: .:..: : :: : ::::::: CCDS22 GSPGPAGPRGPVGPSGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPP 1140 1150 1160 1170 1180 1190 1110 1120 1130 1140 pF1KB4 GVSG---GGYD------FGYD--GDF--YRADQPRSAPSLRPKDYEVDATLKSLNNQIET :. : :: .: . : : : .:.: . .. . :. ..:::.:.:::. CCDS22 GAPGPCCGGVGAAAIAGIGGEKAGGFAPYYGDEPMD---FKINTDEIMTSLKSVNGQIES 1200 1210 1220 1230 1240 1150 1160 1170 1180 1190 1200 pF1KB4 LLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQGCTMDAIKVYCDFSTGETCIRAQP :..:.::::::::.::::.. ::: .:: ::.:::::: .:::::.:.. :::::: :.: CCDS22 LISPDGSRKNPARNCRDLKFCHPELKSGEYWVDPNQGCKLDAIKVFCNMETGETCISANP 1250 1260 1270 1280 1290 1300 1210 1220 1230 1240 1250 1260 pF1KB4 ENIPAKNWYR-SSKDKKHVWLGETINAGSQFEYNVEGVTSKEMATQLAFMRLLANYASQN :.: :.:. :: .:::::.::....: :: :. . . ..:::.:::.. :::: CCDS22 LNVPRKHWWTDSSAEKKHVWFGESMDGGFQFSYGNPELPEDVLDVHLAFLRLLSSRASQN 1310 1320 1330 1340 1350 1360 1270 1280 1290 1300 1310 1320 pF1KB4 ITYHCKNSIAYMDEETGNLKKAVILQGSNDVELVAEGNSRFTYTVLVDGCSKKTNEWGKT :::::::::::::. .::.:::. :.:::. :. :::::.:::::: :::.:.:.::.:: CCDS22 ITYHCKNSIAYMDQASGNVKKALKLMGSNEGEFKAEGNSKFTYTVLEDGCTKHTGEWSKT 1370 1380 1390 1400 1410 1420 1330 1340 1350 1360 pF1KB4 IIEYKTNKPSRLPFLDIAPLDIGGADQEFFVDIGPVCFK ..::.: : :::..:::: :::: :::: ::.::::: CCDS22 VFEYRTRKAVRLPIVDIAPYDIGGPDQEFGVDVGPVCFL 1430 1440 1450 1460 >>CCDS12222.1 COL5A3 gene_id:50509|Hs108|chr19 (1745 aa) initn: 5301 init1: 2998 opt: 3869 Z-score: 1516.8 bits: 293.4 E(32554): 3.6e-78 Smith-Waterman score: 3932; 45.2% identity (59.8% similar) in 1382 aa overlap (32-1365:391-1743) 10 20 30 40 50 pF1KB4 LSFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRG---ERGPPGPPGRDGEDGP .:: : ::.: ::::::: :. :: CCDS12 PSRTQFQIFPGAGEKGAKGEPAVIEKGQQFEGPPGAPGPQGVVGPSGPPGPPGFPGDPGP 370 380 390 400 410 420 60 70 80 90 pF1KB4 TGPPGPPGPPG------PPGL---------GGNFAA------QYDGKGVGLGPGPMGLMG :: : :: :: ::: ::.: . : ....: : ... : CCDS12 PGPAGLPGIPGIDGIRGPPGTVIMMPFQFAGGSFKGPPVSFQQAQAQAV-LQQTQLSMKG 430 440 450 460 470 100 110 120 130 140 150 pF1KB4 PRGPPGAAGAPGPQGFQGPAGEPGEPGQTGPAGARG---PAGPPGKAGEDGHPGKPGRPG : :: : .: ::: :. : : :: : :: : :: : ::::..:. :.:: : : CCDS12 PPGPVGLTGRPGPVGLPGHPGLKGEEGAEGPQGPRGLQGPHGPPGRVGKMGRPGADGARG 480 490 500 510 520 530 160 170 180 190 200 210 pF1KB4 ERGVVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTG : .::.: ::: : ::::: :: :: : : : :: : .: : :: .: :. : CCDS12 LPGDTGPKGDRGFDGLPGLPGEKGQRGDFGHVGQPGPPGEDGERGAEGPPGPTGQAGEPG 540 550 560 570 580 590 220 230 240 250 260 270 pF1KB4 ARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAG ::: : :: : : :. : ::. : : .:: : :::: : : .: : : : CCDS12 PRGLLGPRGSPGPTGRPGVTGIDGAPGAKGNVGPPGEPGPPGQQGNHGSQGLPGPQGLIG 600 610 620 630 640 650 280 290 300 310 320 330 pF1KB4 PAGPAGPRGEVGLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVG : :: :. :.::: : :: :.:: .: :: ::: : :: :: :: :::::. : : CCDS12 TPGEKGPPGNPGIPGLPGSDGPLGHPGHEGPTGEKGAQGPPGSAGPPGYPGPRGVKGTSG 660 670 680 690 700 710 340 350 360 370 380 390 pF1KB4 AAGATGARGLVGEPGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPG : : .: :: : : ::. : ::. :. : : ::: ::.: .::.:.::.:: : CCDS12 NRGLQGEKGEKGEDGFPGFKGDVGLKGDQGK--P-GAPGPRGEDGPEGPKGQAGQAGEEG 720 730 740 750 760 770 400 410 420 430 440 450 pF1KB4 PPGLRGSPGSRGLPGADGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPG ::: : :. :.:: : : :: :: : :: : : .: .:. :.::: : :: :: CCDS12 PPGSAGEKGKLGVPGLPGYPGRPGPKGSIGFPGPLGPIGEKGKSGKTGQPGLEGERGPPG 780 790 800 810 820 830 460 470 480 490 500 510 pF1KB4 SPGNIG-PA--GKEGPVGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNGDKG : :. : :. :. :: : : :: :: : : : : :::::::: : ::.: : CCDS12 SRGERGQPGATGQPGPKGDVGQDGAPGIPGEKGLPGLQGPPGFPGPKGPPGHQGKDGRPG 840 850 860 870 880 890 520 530 540 550 560 570 pF1KB4 HAGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPAGPPGFQGLPGPSGPAGEVGKPG : : :: : .:.. ::::: :: : .:. : .:: : .: ::: :: :: : :: CCDS12 H---PGQRGELGFQGQT---GPPGPAGVLGPQGKTGEVGPLGERGPPGPPGPPGEQGLPG 900 910 920 930 940 950 580 590 600 610 620 pF1KB4 ---ERGLHGEFGLPGP---AGPRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPG ..: .::.: ::: :: : :: :: .:. : :: : .: .::::: : .: :: CCDS12 LEGREGAKGELGPPGPLGKEGPAGLRGFPGPKGGPGDPGPTGLKGDKGPPGPVGANGSPG 960 970 980 990 1000 1010 630 640 650 660 670 680 pF1KB4 VVGAVGTAGPSGPSGLPGERGAAGIPGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPG : .: :.: ::::. :. : : :.:: ::: : :: : : :: .: : CCDS12 ERGPLG---PAGGIGLPGQSGSEGPVGPAGKKGS---RGERGPPGPTGKDGIPGPLGPLG 1020 1030 1040 1050 1060 690 700 710 720 730 740 pF1KB4 PAGATGDRGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKG : ::.: :: : : .: : .:: :..:..:: : :. :::: : ::: : .: .: CCDS12 PPGAAGPSGEEGDKGDVGAPGHKGSKGDKGDAGPPGQPGIRGPAGHPGPPGADGAQGRRG 1070 1080 1090 1100 1110 1120 750 760 770 780 790 800 pF1KB4 PKG---ENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSG : : ..: : : ::. :: : .: ::: : .:. : : : :: : :: ::.: CCDS12 PPGLFGQKGDDGVRGFVGVIGPPGLQGLPGPPGEKGEVGDVGSMGPHGAPGPRGPQGPTG 1130 1140 1150 1160 1170 1180 810 820 830 840 850 860 pF1KB4 ISGPPGPPGPAGKEGLRGPRGDQGPVGRTGEVGAVGPPGFAGEKGPSGEAGTAGPPGTPG : :: :: .:. : : .:..: .: : :: ::. : :: :: : .:: :. : CCDS12 SEGTPGLPGGVGQPGAVGEKGERGDAGDPGPPGA---PGIPGPKGDIGEKGDSGPSGAAG 1190 1200 1210 1220 1230 1240 870 880 890 900 910 920 pF1KB4 PQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIAGPPGARGPPGAVGSPGVNGAPG : : : :: : :: : :::: : :.:: :: : :: .: :: ::.:: :: : CCDS12 PPGKKGPPGEDGAKGSVGPTGLPGDLGPPGDPGVSGIDGSPGEKGDPGDVGGPGPPGASG 1250 1260 1270 1280 1290 1300 930 940 950 960 970 980 pF1KB4 EAGRDGNPGNDGPPGRDGQPGHKGERGYPGNIGPVGAAGAPGPHGPVGPAGKHGNRGETG : : : ::. :: :. :. :..::.: :. :: : : :: : :: :. : .: : CCDS12 EPGAPGPPGKRGPSGHMGREGREGEKGAKGEPGPDGPPGRTGPMGARGPPGRVGPEGLRG 1310 1320 1330 1340 1350 1360 990 1000 1010 1020 1030 pF1KB4 PSGPVGPAGAVGPRGPSGPQGIRGDKGEPGEKGPRGLPGLKGHNGLQGL---PGIAGHHG :::: : .: : :: : : .: :: :: : : ::: :: :: :: ::..: CCDS12 IPGPVGEPGLLGAPGQMGPPGPLGPSGLPGLKGDTGPKGEKGHIGLIGLIGPPGEAGEKG 1370 1380 1390 1400 1410 1420 1040 1050 1060 1070 1080 1090 pF1KB4 DQGAPGSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIRGPQGHQGPAGP---PGPPG ::: :: :: ::.: :: :: :. :. : ::..:: : .: .: : :: :: : CCDS12 DQGLPGVQGPPGPKGDPGPPGPIGSLGHPGPPGVAGPLGQKGSKGSPGSMGPRGDTGPAG 1430 1440 1450 1460 1470 1480 1100 1110 1120 1130 1140 1150 pF1KB4 PPGPPGVSGGGYDFGYDGDFYRADQPRSAPSLRPKDYEVDATLKSLNNQIETLLTPEGSR ::::::. . . . : : : .. :: :.: ::. ..: : : :. CCDS12 PPGPPGAPAELHGLRRRRRFV----PVPLPVVEGGLEEVLASLTSLSLELEQLRRPPGTA 1490 1500 1510 1520 1530 1160 1170 1180 1190 1200 1210 pF1KB4 KNPARTCRDLRLSHPEWSSGYYWIDPNQGCTMDAIKVYCDFSTG-ETCIRAQP--ENIPA . :. .:..:. .::. .: :::::::::. :...:.:.:..: :::. . : . CCDS12 ERPGLVCHELHRNHPHLPDGEYWIDPNQGCARDSFRVFCNFTAGGETCLYPDKKFEIVKL 1540 1550 1560 1570 1580 1590 1220 1230 1240 1250 1260 1270 pF1KB4 KNWYRSSKDKKHVWLGETINAGSQFEYNVEGVTSKEMATQLAFMRLLANYASQNITYHCK .: ::.: : . :. :..: : :.. : ..:: :..::. : ::.:: :. CCDS12 ASW---SKEKPGGWYS-TFRRGKKFSY-VDADGSPVNVVQLNFLKLLSATARQNFTYSCQ 1600 1610 1620 1630 1640 1650 1280 1290 1300 1310 1320 1330 pF1KB4 NSIAYMDEETGNLKKAVILQGSNDVELVAEGNSRFTYTVLVDGCSKKTNEWGKTIIEYKT :. :..:: ::. .... . :.: :: . .. : .: ::: . .. ::..:... CCDS12 NAAAWLDEATGDYSHSARFLGTNGEELSFNQTTAATVSVPQDGCRLRKGQ-TKTLFEFSS 1660 1670 1680 1690 1700 1710 1340 1350 1360 pF1KB4 NKPSRLPFLDIAPLDIGGADQEFFVDIGPVCFK .. . ::. :.: :.: ..:.: ..::::: CCDS12 SRAGFLPLWDVAATDFGQTNQKFGFELGPVCFSS 1720 1730 1740 >>CCDS780.2 COL11A1 gene_id:1301|Hs108|chr1 (1690 aa) initn: 8789 init1: 3112 opt: 3662 Z-score: 1437.0 bits: 278.6 E(32554): 1e-73 Smith-Waterman score: 4084; 47.1% identity (60.1% similar) in 1394 aa overlap (33-1365:332-1688) 10 20 30 40 50 60 pF1KB4 SFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRGERGPPGPPGRDGEDGPTGPP :::: :: : .:: :::: :. :: : : CCDS78 GHGAYGEKGQKGEPAVVEPGMLVEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRP 310 320 330 340 350 360 70 80 90 100 pF1KB4 GPPGP---PGPPGLGGNFAAQYDGKGVGLGP---------------GPMGLMGPRGPPGA : :: ::::: . .: : : . :: . ..: :: :: : CCDS78 GLPGADGLPGPPGTMLMLPFRYGGDG-SKGPTISAQEAQAQAILQQARIALRGPPGPMGL 370 380 390 400 410 420 110 120 130 140 150 160 pF1KB4 AGAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGA .: ::: : : .: :: :. :: : :: :::: .:. :. :.:: : ::. : :: CCDS78 TGRPGPVGGPGSSGAKGESGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGA 430 440 450 460 470 480 170 180 190 200 210 220 pF1KB4 ---RGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGE ::: : ::::: :: ::. : .: : :: :..:: : : : ::..: ::: : CCDS78 KGDRGFDGLPGLPGDKGHRGERGPQGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRGLLGP 490 500 510 520 530 540 230 240 250 260 270 280 pF1KB4 RGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGP :: :::: : : :: :: : :: : :::: : :::.: : : :: : :: CCDS78 RGTPGAPGQPGMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGP 550 560 570 580 590 600 290 300 310 320 330 340 pF1KB4 RGEVGLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGA .:. :: :: : ::::.:: .: .: ::: : :: : : :::::. : :. : :. CCDS78 QGKPGLAGLPGADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGS 610 620 630 640 650 660 350 360 370 380 390 400 pF1KB4 RGLVGEPGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPGPPGLRGS .: :: : : ::. : ::. : .: :: ::.: .::.:.:: .: ::: : : CCDS78 KGEKGEDGFPGFKGDMGLKGDRGEVGQIGP---RGEDGPEGPKGRAGPTGDPGPSGQAGE 670 680 690 700 710 410 420 430 440 450 pF1KB4 PGSRGLPGADGRAGVMGPPGSRGASG-PA--GVRGPNGDAGRPGEPGLMGPRGLPGSPGN :. :.:: : : .:: :: : : :. : .: : ::.:: : :: : :: : CCDS78 KGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGA 720 730 740 750 760 770 460 470 480 490 500 510 pF1KB4 IGPAGKEGPVGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNGDKGH------ ::.:: :: : : :: ::: : : .: : .:::::::: : :::.: :: CCDS78 RGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGE 780 790 800 810 820 830 520 530 540 550 560 570 pF1KB4 AGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPAGPPGFQGLPGPSGPAGEVGKPGE .:. : : ::: : : ::: : : : .:. :: :::: ::::: .: : : :: CCDS78 TGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGP 840 850 860 870 880 890 580 590 600 610 620 630 pF1KB4 RGLHGEFGLPGPAGPRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGT .:. :. :::: :: : : :: : : :..::.::::: :. :: : . CCDS78 QGISGK---DGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERG------S 900 910 920 930 940 640 650 660 670 680 690 pF1KB4 AGPSGPSGLPGERGAAGIPGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGD :: .:: ::::. : : :: :::: :: .: : ::::..: : :: ::::: .:. CCDS78 AGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQG-P--VGLPGPAGPAGS 950 960 970 980 990 1000 700 710 720 730 740 750 pF1KB4 RGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKGPKGENGV :: : : : : .:: :..:: :: :: :. ::.:: :: : : ::.:..:. CCDS78 PGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGA---PGIAGGDGEPGPRGQQGM 1010 1020 1030 1040 1050 1060 760 770 780 790 800 pF1KB4 VGPTGPVGAAGPAGPNGPPGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGPPGP--- : : :: : : ::::: : .: :::: : : .: ::::: : :: :: CCDS78 FGQKGDEGARG--FP-GPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGA 1070 1080 1090 1100 1110 810 820 830 840 850 860 pF1KB4 PGPAGKEGLRGPRGDQGPVGRTGEVGAVGPPGFAGEKGPSGE---AGTAGPPGTPGPQGL :: : : : : : :. ::.: :::: :: ::.:: : :::::. :: : CCDS78 DGPQGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGA 1120 1130 1140 1150 1160 1170 870 880 890 900 910 920 pF1KB4 LGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIAGPPGARGPPGAVGSPGVNGAPGEAGR : :: : :. : :.:: : ::::: : : : .: : :.:: : :::: CCDS78 KGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGP 1180 1190 1200 1210 1220 1230 930 940 950 960 970 980 pF1KB4 DGNPGNDGPPGRDGQPGHKGERGYPGNIGPVGAAGAPGPHGPVGPAGKHGNRGETGPSGP : ::. :::: : :..::.: :. : : : :: :: ::::: : .: : :: CCDS78 PGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGP 1240 1250 1260 1270 1280 1290 990 1000 1010 1020 1030 1040 pF1KB4 VG----P--AGAVGPRGPSGPQGIRGDKGEPGEKGPRGLPGLKGHNGLQGLPGIAGHHGD :: : :: :: :: :: :. : ::.:: :: .: ::: :: : :: :..:: CCDS78 VGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGL---IGLIGPPGEQGEKGD 1300 1310 1320 1330 1340 1350 1050 1060 1070 1080 1090 pF1KB4 QGAPGSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIRGPQGHQGPAGP------PGP .: ::. : : .: .: :::: : : :: :: : .: .: :::: ::: CCDS78 RGLPGTQGSPGAKGDGGIPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGP 1360 1370 1380 1390 1400 1410 1100 1110 1120 1130 1140 pF1KB4 PGPPGPPG--------VSGGGYDFGYDGDFYRADQPRSAPSLRPKDYEVDATLKSLNNQI :: ::::: .:. .: ..:: . . :. ..:.::...: CCDS78 PGSPGPPGEVIQPLPILSSKKTRRHTEG--MQADADDNILDYSDGMEEIFGSLNSLKQDI 1420 1430 1440 1450 1460 1470 1150 1160 1170 1180 1190 1200 pF1KB4 ETLLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQGCTMDAIKVYCDFSTG-ETCIR : . : :.. ::::::.::.::::.. .: :::::::::. :..::::.:..: :::: CCDS78 EHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTSGGETCIY 1480 1490 1500 1510 1520 1530 1210 1220 1230 1240 1250 1260 pF1KB4 A--QPENIPAKNWYRSSKDKKHVWLGETINAGSQFEY-NVEGVTSKEMATQLAFMRLLAN . :.. ..: :.: :..: .. :. . : .::: .: .:. :..:..::. CCDS78 PDKKSEGVRISSW---PKEKPGSWFSE-FKRGKLLSYLDVEG-NSINMV-QMTFLKLLTA 1540 1550 1560 1570 1580 1270 1280 1290 1300 1310 1320 pF1KB4 YASQNITYHCKNSIAYMDEETGNLKKAVILQGSNDVELVAEGNSRFTYTVLVDGC-SKKT : ::.::::..: :..: .:. ::. . :::: :. ..: : : : ::: :.: CCDS78 SARQNFTYHCHQSAAWYDVSSGSYDKALRFLGSNDEEMSYDNNP-FIKT-LYDGCASRKG 1590 1600 1610 1620 1630 1640 1330 1340 1350 1360 pF1KB4 NEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFFVDIGPVCFK : ::.:: .: : ...:..:. :.: .:.: ..::::: CCDS78 YE--KTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVGPVCFLG 1650 1660 1670 1680 1690 >>CCDS53348.1 COL11A1 gene_id:1301|Hs108|chr1 (1767 aa) initn: 8789 init1: 3112 opt: 3662 Z-score: 1436.8 bits: 278.6 E(32554): 1e-73 Smith-Waterman score: 4084; 47.1% identity (60.1% similar) in 1394 aa overlap (33-1365:409-1765) 10 20 30 40 50 60 pF1KB4 SFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRGERGPPGPPGRDGEDGPTGPP :::: :: : .:: :::: :. :: : : CCDS53 GHGAYGEKGQKGEPAVVEPGMLVEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRP 380 390 400 410 420 430 70 80 90 100 pF1KB4 GPPGP---PGPPGLGGNFAAQYDGKGVGLGP---------------GPMGLMGPRGPPGA : :: ::::: . .: : : . :: . ..: :: :: : CCDS53 GLPGADGLPGPPGTMLMLPFRYGGDG-SKGPTISAQEAQAQAILQQARIALRGPPGPMGL 440 450 460 470 480 490 110 120 130 140 150 160 pF1KB4 AGAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGA .: ::: : : .: :: :. :: : :: :::: .:. :. :.:: : ::. : :: CCDS53 TGRPGPVGGPGSSGAKGESGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGA 500 510 520 530 540 550 170 180 190 200 210 220 pF1KB4 ---RGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGE ::: : ::::: :: ::. : .: : :: :..:: : : : ::..: ::: : CCDS53 KGDRGFDGLPGLPGDKGHRGERGPQGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRGLLGP 560 570 580 590 600 610 230 240 250 260 270 280 pF1KB4 RGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGP :: :::: : : :: :: : :: : :::: : :::.: : : :: : :: CCDS53 RGTPGAPGQPGMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGP 620 630 640 650 660 670 290 300 310 320 330 340 pF1KB4 RGEVGLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGA .:. :: :: : ::::.:: .: .: ::: : :: : : :::::. : :. : :. CCDS53 QGKPGLAGLPGADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGS 680 690 700 710 720 730 350 360 370 380 390 400 pF1KB4 RGLVGEPGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPGPPGLRGS .: :: : : ::. : ::. : .: :: ::.: .::.:.:: .: ::: : : CCDS53 KGEKGEDGFPGFKGDMGLKGDRGEVGQIGP---RGEDGPEGPKGRAGPTGDPGPSGQAGE 740 750 760 770 780 790 410 420 430 440 450 pF1KB4 PGSRGLPGADGRAGVMGPPGSRGASG-PA--GVRGPNGDAGRPGEPGLMGPRGLPGSPGN :. :.:: : : .:: :: : : :. : .: : ::.:: : :: : :: : CCDS53 KGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGA 800 810 820 830 840 850 460 470 480 490 500 510 pF1KB4 IGPAGKEGPVGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNGDKGH------ ::.:: :: : : :: ::: : : .: : .:::::::: : :::.: :: CCDS53 RGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGE 860 870 880 890 900 910 520 530 540 550 560 570 pF1KB4 AGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPAGPPGFQGLPGPSGPAGEVGKPGE .:. : : ::: : : ::: : : : .:. :: :::: ::::: .: : : :: CCDS53 TGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGP 920 930 940 950 960 970 580 590 600 610 620 630 pF1KB4 RGLHGEFGLPGPAGPRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGT .:. :. :::: :: : : :: : : :..::.::::: :. :: : . CCDS53 QGISGK---DGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERG------S 980 990 1000 1010 1020 640 650 660 670 680 690 pF1KB4 AGPSGPSGLPGERGAAGIPGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGD :: .:: ::::. : : :: :::: :: .: : ::::..: : :: ::::: .:. CCDS53 AGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQG-P--VGLPGPAGPAGS 1030 1040 1050 1060 1070 1080 700 710 720 730 740 750 pF1KB4 RGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKGPKGENGV :: : : : : .:: :..:: :: :: :. ::.:: :: : : ::.:..:. CCDS53 PGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGA---PGIAGGDGEPGPRGQQGM 1090 1100 1110 1120 1130 760 770 780 790 800 pF1KB4 VGPTGPVGAAGPAGPNGPPGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGPPGP--- : : :: : : ::::: : .: :::: : : .: ::::: : :: :: CCDS53 FGQKGDEGARG--FP-GPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGA 1140 1150 1160 1170 1180 1190 810 820 830 840 850 860 pF1KB4 PGPAGKEGLRGPRGDQGPVGRTGEVGAVGPPGFAGEKGPSGE---AGTAGPPGTPGPQGL :: : : : : : :. ::.: :::: :: ::.:: : :::::. :: : CCDS53 DGPQGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGA 1200 1210 1220 1230 1240 1250 870 880 890 900 910 920 pF1KB4 LGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIAGPPGARGPPGAVGSPGVNGAPGEAGR : :: : :. : :.:: : ::::: : : : .: : :.:: : :::: CCDS53 KGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGP 1260 1270 1280 1290 1300 1310 930 940 950 960 970 980 pF1KB4 DGNPGNDGPPGRDGQPGHKGERGYPGNIGPVGAAGAPGPHGPVGPAGKHGNRGETGPSGP : ::. :::: : :..::.: :. : : : :: :: ::::: : .: : :: CCDS53 PGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGP 1320 1330 1340 1350 1360 1370 990 1000 1010 1020 1030 1040 pF1KB4 VG----P--AGAVGPRGPSGPQGIRGDKGEPGEKGPRGLPGLKGHNGLQGLPGIAGHHGD :: : :: :: :: :: :. : ::.:: :: .: ::: :: : :: :..:: CCDS53 VGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGL---IGLIGPPGEQGEKGD 1380 1390 1400 1410 1420 1430 1050 1060 1070 1080 1090 pF1KB4 QGAPGSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIRGPQGHQGPAGP------PGP .: ::. : : .: .: :::: : : :: :: : .: .: :::: ::: CCDS53 RGLPGTQGSPGAKGDGGIPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGP 1440 1450 1460 1470 1480 1490 1100 1110 1120 1130 1140 pF1KB4 PGPPGPPG--------VSGGGYDFGYDGDFYRADQPRSAPSLRPKDYEVDATLKSLNNQI :: ::::: .:. .: ..:: . . :. ..:.::...: CCDS53 PGSPGPPGEVIQPLPILSSKKTRRHTEG--MQADADDNILDYSDGMEEIFGSLNSLKQDI 1500 1510 1520 1530 1540 1550 1150 1160 1170 1180 1190 1200 pF1KB4 ETLLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQGCTMDAIKVYCDFSTG-ETCIR : . : :.. ::::::.::.::::.. .: :::::::::. :..::::.:..: :::: CCDS53 EHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTSGGETCIY 1560 1570 1580 1590 1600 1610 1210 1220 1230 1240 1250 1260 pF1KB4 A--QPENIPAKNWYRSSKDKKHVWLGETINAGSQFEY-NVEGVTSKEMATQLAFMRLLAN . :.. ..: :.: :..: .. :. . : .::: .: .:. :..:..::. CCDS53 PDKKSEGVRISSW---PKEKPGSWFSE-FKRGKLLSYLDVEG-NSINMV-QMTFLKLLTA 1620 1630 1640 1650 1660 1270 1280 1290 1300 1310 1320 pF1KB4 YASQNITYHCKNSIAYMDEETGNLKKAVILQGSNDVELVAEGNSRFTYTVLVDGC-SKKT : ::.::::..: :..: .:. ::. . :::: :. ..: : : : ::: :.: CCDS53 SARQNFTYHCHQSAAWYDVSSGSYDKALRFLGSNDEEMSYDNNP-FIKT-LYDGCASRKG 1670 1680 1690 1700 1710 1720 1330 1340 1350 1360 pF1KB4 NEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFFVDIGPVCFK : ::.:: .: : ...:..:. :.: .:.: ..::::: CCDS53 YE--KTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVGPVCFLG 1730 1740 1750 1760 >>CCDS778.1 COL11A1 gene_id:1301|Hs108|chr1 (1806 aa) initn: 8789 init1: 3112 opt: 3662 Z-score: 1436.7 bits: 278.7 E(32554): 1e-73 Smith-Waterman score: 4084; 47.1% identity (60.1% similar) in 1394 aa overlap (33-1365:448-1804) 10 20 30 40 50 60 pF1KB4 SFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRGERGPPGPPGRDGEDGPTGPP :::: :: : .:: :::: :. :: : : CCDS77 GHGAYGEKGQKGEPAVVEPGMLVEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRP 420 430 440 450 460 470 70 80 90 100 pF1KB4 GPPGP---PGPPGLGGNFAAQYDGKGVGLGP---------------GPMGLMGPRGPPGA : :: ::::: . .: : : . :: . ..: :: :: : CCDS77 GLPGADGLPGPPGTMLMLPFRYGGDG-SKGPTISAQEAQAQAILQQARIALRGPPGPMGL 480 490 500 510 520 530 110 120 130 140 150 160 pF1KB4 AGAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGA .: ::: : : .: :: :. :: : :: :::: .:. :. :.:: : ::. : :: CCDS77 TGRPGPVGGPGSSGAKGESGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGA 540 550 560 570 580 590 170 180 190 200 210 220 pF1KB4 ---RGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGE ::: : ::::: :: ::. : .: : :: :..:: : : : ::..: ::: : CCDS77 KGDRGFDGLPGLPGDKGHRGERGPQGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRGLLGP 600 610 620 630 640 650 230 240 250 260 270 280 pF1KB4 RGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGP :: :::: : : :: :: : :: : :::: : :::.: : : :: : :: CCDS77 RGTPGAPGQPGMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGP 660 670 680 690 700 710 290 300 310 320 330 340 pF1KB4 RGEVGLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGA .:. :: :: : ::::.:: .: .: ::: : :: : : :::::. : :. : :. CCDS77 QGKPGLAGLPGADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGS 720 730 740 750 760 770 350 360 370 380 390 400 pF1KB4 RGLVGEPGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPGPPGLRGS .: :: : : ::. : ::. : .: :: ::.: .::.:.:: .: ::: : : CCDS77 KGEKGEDGFPGFKGDMGLKGDRGEVGQIGP---RGEDGPEGPKGRAGPTGDPGPSGQAGE 780 790 800 810 820 830 410 420 430 440 450 pF1KB4 PGSRGLPGADGRAGVMGPPGSRGASG-PA--GVRGPNGDAGRPGEPGLMGPRGLPGSPGN :. :.:: : : .:: :: : : :. : .: : ::.:: : :: : :: : CCDS77 KGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGA 840 850 860 870 880 890 460 470 480 490 500 510 pF1KB4 IGPAGKEGPVGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNGDKGH------ ::.:: :: : : :: ::: : : .: : .:::::::: : :::.: :: CCDS77 RGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGE 900 910 920 930 940 950 520 530 540 550 560 570 pF1KB4 AGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPAGPPGFQGLPGPSGPAGEVGKPGE .:. : : ::: : : ::: : : : .:. :: :::: ::::: .: : : :: CCDS77 TGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGP 960 970 980 990 1000 1010 580 590 600 610 620 630 pF1KB4 RGLHGEFGLPGPAGPRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGT .:. :. :::: :: : : :: : : :..::.::::: :. :: : . CCDS77 QGISGK---DGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERG------S 1020 1030 1040 1050 1060 640 650 660 670 680 690 pF1KB4 AGPSGPSGLPGERGAAGIPGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGD :: .:: ::::. : : :: :::: :: .: : ::::..: : :: ::::: .:. CCDS77 AGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQG-P--VGLPGPAGPAGS 1070 1080 1090 1100 1110 1120 700 710 720 730 740 750 pF1KB4 RGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKGPKGENGV :: : : : : .:: :..:: :: :: :. ::.:: :: : : ::.:..:. CCDS77 PGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGA---PGIAGGDGEPGPRGQQGM 1130 1140 1150 1160 1170 760 770 780 790 800 pF1KB4 VGPTGPVGAAGPAGPNGPPGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGPPGP--- : : :: : : ::::: : .: :::: : : .: ::::: : :: :: CCDS77 FGQKGDEGARG--FP-GPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGA 1180 1190 1200 1210 1220 1230 810 820 830 840 850 860 pF1KB4 PGPAGKEGLRGPRGDQGPVGRTGEVGAVGPPGFAGEKGPSGE---AGTAGPPGTPGPQGL :: : : : : : :. ::.: :::: :: ::.:: : :::::. :: : CCDS77 DGPQGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGA 1240 1250 1260 1270 1280 1290 870 880 890 900 910 920 pF1KB4 LGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIAGPPGARGPPGAVGSPGVNGAPGEAGR : :: : :. : :.:: : ::::: : : : .: : :.:: : :::: CCDS77 KGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGP 1300 1310 1320 1330 1340 1350 930 940 950 960 970 980 pF1KB4 DGNPGNDGPPGRDGQPGHKGERGYPGNIGPVGAAGAPGPHGPVGPAGKHGNRGETGPSGP : ::. :::: : :..::.: :. : : : :: :: ::::: : .: : :: CCDS77 PGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGP 1360 1370 1380 1390 1400 1410 990 1000 1010 1020 1030 1040 pF1KB4 VG----P--AGAVGPRGPSGPQGIRGDKGEPGEKGPRGLPGLKGHNGLQGLPGIAGHHGD :: : :: :: :: :: :. : ::.:: :: .: ::: :: : :: :..:: CCDS77 VGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGL---IGLIGPPGEQGEKGD 1420 1430 1440 1450 1460 1470 1050 1060 1070 1080 1090 pF1KB4 QGAPGSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIRGPQGHQGPAGP------PGP .: ::. : : .: .: :::: : : :: :: : .: .: :::: ::: CCDS77 RGLPGTQGSPGAKGDGGIPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGP 1480 1490 1500 1510 1520 1530 1100 1110 1120 1130 1140 pF1KB4 PGPPGPPG--------VSGGGYDFGYDGDFYRADQPRSAPSLRPKDYEVDATLKSLNNQI :: ::::: .:. .: ..:: . . :. ..:.::...: CCDS77 PGSPGPPGEVIQPLPILSSKKTRRHTEG--MQADADDNILDYSDGMEEIFGSLNSLKQDI 1540 1550 1560 1570 1580 1590 1150 1160 1170 1180 1190 1200 pF1KB4 ETLLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQGCTMDAIKVYCDFSTG-ETCIR : . : :.. ::::::.::.::::.. .: :::::::::. :..::::.:..: :::: CCDS77 EHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTSGGETCIY 1600 1610 1620 1630 1640 1650 1210 1220 1230 1240 1250 1260 pF1KB4 A--QPENIPAKNWYRSSKDKKHVWLGETINAGSQFEY-NVEGVTSKEMATQLAFMRLLAN . :.. ..: :.: :..: .. :. . : .::: .: .:. :..:..::. CCDS77 PDKKSEGVRISSW---PKEKPGSWFSE-FKRGKLLSYLDVEG-NSINMV-QMTFLKLLTA 1660 1670 1680 1690 1700 1270 1280 1290 1300 1310 1320 pF1KB4 YASQNITYHCKNSIAYMDEETGNLKKAVILQGSNDVELVAEGNSRFTYTVLVDGC-SKKT : ::.::::..: :..: .:. ::. . :::: :. ..: : : : ::: :.: CCDS77 SARQNFTYHCHQSAAWYDVSSGSYDKALRFLGSNDEEMSYDNNP-FIKT-LYDGCASRKG 1710 1720 1730 1740 1750 1760 1330 1340 1350 1360 pF1KB4 NEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFFVDIGPVCFK : ::.:: .: : ...:..:. :.: .:.: ..::::: CCDS77 YE--KTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVGPVCFLG 1770 1780 1790 1800 1366 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 15:27:34 2016 done: Thu Nov 3 15:27:35 2016 Total Scan time: 6.460 Total Display time: 0.800 Function used was FASTA [36.3.4 Apr, 2011]