FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4741, 1145 aa 1>>>pF1KB4741 1145 - 1145 aa - 1145 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.7371+/-0.000453; mu= 14.9288+/- 0.028 mean_var=107.1389+/-19.920, 0's: 0 Z-trim(113.2): 414 B-trim: 157 in 1/54 Lambda= 0.123908 statistics sampled from 21981 (22428) to 21981 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.263), width: 16 Scan time: 10.800 The best scores are: opt bits E(85289) NP_563578 (OMIM: 151460,608971,609532) receptor-ty (1145) 7726 1393.0 0 XP_006711537 (OMIM: 151460,608971,609532) PREDICTE (1192) 7515 1355.3 0 XP_006711535 (OMIM: 151460,608971,609532) PREDICTE (1258) 7515 1355.3 0 XP_006711536 (OMIM: 151460,608971,609532) PREDICTE (1240) 7510 1354.5 0 NP_002829 (OMIM: 151460,608971,609532) receptor-ty (1306) 7510 1354.5 0 NP_543031 (OMIM: 176884) receptor-type tyrosine-pr ( 793) 1069 202.9 6.3e-51 NP_543030 (OMIM: 176884) receptor-type tyrosine-pr ( 793) 1069 202.9 6.3e-51 NP_002827 (OMIM: 176884) receptor-type tyrosine-pr ( 802) 1069 202.9 6.3e-51 XP_011538298 (OMIM: 600926) PREDICTED: receptor-ty ( 678) 996 189.9 4.7e-47 XP_011538296 (OMIM: 600926) PREDICTED: receptor-ty ( 719) 993 189.3 7.1e-47 NP_569119 (OMIM: 600926) receptor-type tyrosine-pr ( 642) 992 189.1 7.3e-47 NP_001310283 (OMIM: 600926) receptor-type tyrosine ( 700) 992 189.1 7.9e-47 NP_006495 (OMIM: 600926) receptor-type tyrosine-pr ( 700) 992 189.1 7.9e-47 XP_016871957 (OMIM: 600926) PREDICTED: receptor-ty ( 700) 992 189.1 7.9e-47 NP_001303606 (OMIM: 600926) receptor-type tyrosine ( 700) 992 189.1 7.9e-47 XP_005252748 (OMIM: 600926) PREDICTED: receptor-ty ( 700) 992 189.1 7.9e-47 NP_001303605 (OMIM: 600926) receptor-type tyrosine ( 711) 992 189.1 8e-47 XP_011538297 (OMIM: 600926) PREDICTED: receptor-ty ( 711) 992 189.1 8e-47 NP_001310285 (OMIM: 600926) receptor-type tyrosine ( 718) 992 189.2 8e-47 NP_001310284 (OMIM: 600926) receptor-type tyrosine ( 720) 992 189.2 8.1e-47 XP_016871956 (OMIM: 600926) PREDICTED: receptor-ty ( 720) 992 189.2 8.1e-47 XP_016871958 (OMIM: 600926) PREDICTED: receptor-ty ( 482) 951 181.7 9.3e-45 NP_001316069 (OMIM: 179590,616001) receptor-type t (1603) 943 180.6 6.8e-44 XP_016857436 (OMIM: 179590,616001) PREDICTED: rece (1618) 943 180.6 6.9e-44 NP_001316068 (OMIM: 179590,616001) receptor-type t (1623) 943 180.6 6.9e-44 XP_016857438 (OMIM: 179590,616001) PREDICTED: rece (1623) 943 180.6 6.9e-44 XP_016857435 (OMIM: 179590,616001) PREDICTED: rece (1627) 943 180.6 6.9e-44 NP_001316066 (OMIM: 179590,616001) receptor-type t (1629) 943 180.6 6.9e-44 NP_001316067 (OMIM: 179590,616001) receptor-type t (1637) 943 180.6 6.9e-44 XP_006710864 (OMIM: 179590,616001) PREDICTED: rece (1729) 943 180.6 7.3e-44 XP_005271139 (OMIM: 179590,616001) PREDICTED: rece (1796) 943 180.6 7.5e-44 XP_016857433 (OMIM: 179590,616001) PREDICTED: rece (1800) 943 180.6 7.5e-44 XP_016857434 (OMIM: 179590,616001) PREDICTED: rece (1807) 943 180.6 7.5e-44 XP_006710863 (OMIM: 179590,616001) PREDICTED: rece (1811) 943 180.6 7.5e-44 XP_016857432 (OMIM: 179590,616001) PREDICTED: rece (1816) 943 180.6 7.6e-44 XP_006710862 (OMIM: 179590,616001) PREDICTED: rece (1820) 943 180.6 7.6e-44 NP_569707 (OMIM: 179590,616001) receptor-type tyro (1898) 943 180.6 7.8e-44 XP_006710861 (OMIM: 179590,616001) PREDICTED: rece (1902) 943 180.6 7.9e-44 NP_002831 (OMIM: 179590,616001) receptor-type tyro (1907) 943 180.6 7.9e-44 XP_005271138 (OMIM: 179590,616001) PREDICTED: rece (1909) 943 180.6 7.9e-44 XP_006710860 (OMIM: 179590,616001) PREDICTED: rece (1911) 943 180.6 7.9e-44 XP_016857431 (OMIM: 179590,616001) PREDICTED: rece (1912) 943 180.6 7.9e-44 XP_006710859 (OMIM: 179590,616001) PREDICTED: rece (1913) 943 180.6 7.9e-44 XP_005271137 (OMIM: 179590,616001) PREDICTED: rece (1918) 943 180.6 7.9e-44 XP_011540173 (OMIM: 179590,616001) PREDICTED: rece (1922) 943 180.6 7.9e-44 XP_005271136 (OMIM: 179590,616001) PREDICTED: rece (1922) 943 180.6 7.9e-44 XP_011540175 (OMIM: 179590,616001) PREDICTED: rece (1922) 943 180.6 7.9e-44 XP_011540174 (OMIM: 179590,616001) PREDICTED: rece (1922) 943 180.6 7.9e-44 XP_006710858 (OMIM: 179590,616001) PREDICTED: rece (1922) 943 180.6 7.9e-44 XP_005259667 (OMIM: 601576) PREDICTED: receptor-ty (1497) 933 178.8 2.2e-43 >>NP_563578 (OMIM: 151460,608971,609532) receptor-type t (1145 aa) initn: 7726 init1: 7726 opt: 7726 Z-score: 7464.3 bits: 1393.0 E(85289): 0 Smith-Waterman score: 7726; 100.0% identity (100.0% similar) in 1145 aa overlap (1-1145:1-1145) 10 20 30 40 50 60 pF1KB4 MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTDAYLNASETTTLSPSGSAVISTTTIAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTDAYLNASETTTLSPSGSAVISTTTIAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 TPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 TPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 SISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 SISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 FQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 FQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 SEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 YIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 YIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 VEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 VEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 FLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 FLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLET 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 YKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEING :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 YKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEING 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB4 DAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 DAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB4 CAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 CAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPD 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB4 HGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 HGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDV 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB4 YGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 YGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEP 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB4 SPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 SPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB4 DESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 DESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVML 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB4 TELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 TELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQ 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB4 YTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 YTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCA 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB4 LLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 LLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNH 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB4 QEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_563 QEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPA 1090 1100 1110 1120 1130 1140 pF1KB4 LNQGS ::::: NP_563 LNQGS >>XP_006711537 (OMIM: 151460,608971,609532) PREDICTED: r (1192 aa) initn: 7506 init1: 7506 opt: 7515 Z-score: 7260.2 bits: 1355.3 E(85289): 0 Smith-Waterman score: 7520; 96.0% identity (96.0% similar) in 1177 aa overlap (16-1145:16-1192) 10 20 30 pF1KB4 MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPT--------------------------- :::::::::::::::::: XP_006 MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGVSSVQTPHLPTHADSQTPSAGTDTQT 10 20 30 40 50 60 40 50 60 70 pF1KB4 --------------------DAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYAN :::::::::::::::::::::::::::::::::::::::: XP_006 FSGSAANAKLNPTPGSNAISDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYAN 70 80 90 100 110 120 80 90 100 110 120 130 pF1KB4 ITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKT 130 140 150 160 170 180 140 150 160 170 180 190 pF1KB4 LILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEI 190 200 210 220 230 240 200 210 220 230 240 250 pF1KB4 KLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNP 250 260 270 280 290 300 260 270 280 290 300 310 pF1KB4 PQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAA 310 320 330 340 350 360 320 330 340 350 360 370 pF1KB4 MCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESH 370 380 390 400 410 420 380 390 400 410 420 430 pF1KB4 KNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIAL 430 440 450 460 470 480 440 450 460 470 480 490 pF1KB4 LVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFL 490 500 510 520 530 540 500 510 520 530 540 550 pF1KB4 AEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYID 550 560 570 580 590 600 560 570 580 590 600 610 pF1KB4 GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTR 610 620 630 640 650 660 620 630 640 650 660 670 pF1KB4 AFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKL 670 680 690 700 710 720 680 690 700 710 720 730 pF1KB4 RRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCL 730 740 750 760 770 780 740 750 760 770 780 790 pF1KB4 MVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSY 790 800 810 820 830 840 800 810 820 830 840 850 pF1KB4 RSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEP 850 860 870 880 890 900 860 870 880 890 900 910 pF1KB4 SKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQ 910 920 930 940 950 960 920 930 940 950 960 970 pF1KB4 YWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEP 970 980 990 1000 1010 1020 980 990 1000 1010 1020 1030 pF1KB4 KELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEV 1030 1040 1050 1060 1070 1080 1040 1050 1060 1070 1080 1090 pF1KB4 VDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDK 1090 1100 1110 1120 1130 1140 1100 1110 1120 1130 1140 pF1KB4 VKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS 1150 1160 1170 1180 1190 >>XP_006711535 (OMIM: 151460,608971,609532) PREDICTED: r (1258 aa) initn: 7506 init1: 7506 opt: 7515 Z-score: 7259.9 bits: 1355.3 E(85289): 0 Smith-Waterman score: 7515; 99.4% identity (99.6% similar) in 1122 aa overlap (27-1145:137-1258) 10 20 30 40 50 pF1KB4 MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSP---TDAYLNASETTTLSPSGSAVI .:::. .:::::::::::::::::::: XP_006 PHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDAYLNASETTTLSPSGSAVI 110 120 130 140 150 160 60 70 80 90 100 110 pF1KB4 STTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 STTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLT 170 180 190 200 210 220 120 130 140 150 160 170 pF1KB4 ECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCD 230 240 250 260 270 280 180 190 200 210 220 230 pF1KB4 TQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGE 290 300 310 320 330 340 240 250 260 270 280 290 pF1KB4 PQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTK 350 360 370 380 390 400 300 310 320 330 340 350 pF1KB4 YVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGP 410 420 430 440 450 460 360 370 380 390 400 410 pF1KB4 HERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSY 470 480 490 500 510 520 420 430 440 450 460 470 pF1KB4 NSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIH 530 540 550 560 570 580 480 490 500 510 520 530 pF1KB4 ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRV 590 600 610 620 630 640 540 550 560 570 580 590 pF1KB4 ELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRC 650 660 670 680 690 700 600 610 620 630 640 650 pF1KB4 EEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHI 710 720 730 740 750 760 660 670 680 690 700 710 pF1KB4 QFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLE 770 780 790 800 810 820 720 730 740 750 760 770 pF1KB4 AENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKK 830 840 850 860 870 880 780 790 800 810 820 830 pF1KB4 RDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMS 890 900 910 920 930 940 840 850 860 870 880 890 pF1KB4 KESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRK 950 960 970 980 990 1000 900 910 920 930 940 950 pF1KB4 VKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDS 1010 1020 1030 1040 1050 1060 960 970 980 990 1000 1010 pF1KB4 RTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQ 1070 1080 1090 1100 1110 1120 1020 1030 1040 1050 1060 1070 pF1KB4 QTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNG 1130 1140 1150 1160 1170 1180 1080 1090 1100 1110 1120 1130 pF1KB4 QVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSV 1190 1200 1210 1220 1230 1240 1140 pF1KB4 NGPASPALNQGS :::::::::::: XP_006 NGPASPALNQGS 1250 >-- initn: 288 init1: 222 opt: 234 Z-score: 225.6 bits: 53.8 E(85289): 7.9e-06 Smith-Waterman score: 234; 63.5% identity (79.4% similar) in 63 aa overlap (1-63:1-60) 10 20 30 40 50 60 pF1KB4 MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTDAYLNASETTTLSPSGSAVISTTTIAT ::::::::::::::::::::::::::::::::: :.... .. : .: . : : : XP_006 MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTG--LTTAKMPSV-PLSSDPLPTHTTAF 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 TPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASV .:. XP_006 SPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQT 60 70 80 90 100 110 >>XP_006711536 (OMIM: 151460,608971,609532) PREDICTED: r (1240 aa) initn: 7510 init1: 7510 opt: 7510 Z-score: 7255.1 bits: 1354.5 E(85289): 0 Smith-Waterman score: 7510; 99.6% identity (99.8% similar) in 1117 aa overlap (29-1145:124-1240) 10 20 30 40 50 pF1KB4 MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTDAYLNASETTTLSPSGSAVISTTTI : . .::::::::::::::::::::::::: XP_006 TDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTI 100 110 120 130 140 150 60 70 80 90 100 110 pF1KB4 ATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNA 160 170 180 190 200 210 120 130 140 150 160 170 pF1KB4 SVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNIT 220 230 240 250 260 270 180 190 200 210 220 230 pF1KB4 YRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIF 280 290 300 310 320 330 240 250 260 270 280 290 pF1KB4 CRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSL 340 350 360 370 380 390 300 310 320 330 340 350 pF1KB4 HAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYH 400 410 420 430 440 450 360 370 380 390 400 410 pF1KB4 LEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKAL 460 470 480 490 500 510 420 430 440 450 460 470 pF1KB4 IAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILL 520 530 540 550 560 570 480 490 500 510 520 530 pF1KB4 ETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEI 580 590 600 610 620 630 540 550 560 570 580 590 pF1KB4 NGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNR 640 650 660 670 680 690 600 610 620 630 640 650 pF1KB4 NKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSW 700 710 720 730 740 750 660 670 680 690 700 710 pF1KB4 PDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKV 760 770 780 790 800 810 720 730 740 750 760 770 pF1KB4 DVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPS 820 830 840 850 860 870 780 790 800 810 820 830 pF1KB4 EPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEH 880 890 900 910 920 930 840 850 860 870 880 890 pF1KB4 DSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIV 940 950 960 970 980 990 900 910 920 930 940 950 pF1KB4 MLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQ 1000 1010 1020 1030 1040 1050 960 970 980 990 1000 1010 pF1KB4 YQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIF 1060 1070 1080 1090 1100 1110 1020 1030 1040 1050 1060 1070 pF1KB4 CALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKN 1120 1130 1140 1150 1160 1170 1080 1090 1100 1110 1120 1130 pF1KB4 NHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPAS 1180 1190 1200 1210 1220 1230 1140 pF1KB4 PALNQGS ::::::: XP_006 PALNQGS 1240 >-- initn: 269 init1: 222 opt: 222 Z-score: 214.1 bits: 51.6 E(85289): 3.5e-05 Smith-Waterman score: 222; 100.0% identity (100.0% similar) in 33 aa overlap (1-33:1-33) 10 20 30 40 50 60 pF1KB4 MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTDAYLNASETTTLSPSGSAVISTTTIAT ::::::::::::::::::::::::::::::::: XP_006 MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGVSSVQTPHLPTHADSQTPSAGTDTQT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 TPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASV XP_006 FSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSN 70 80 90 100 110 120 >>NP_002829 (OMIM: 151460,608971,609532) receptor-type t (1306 aa) initn: 7510 init1: 7510 opt: 7510 Z-score: 7254.8 bits: 1354.5 E(85289): 0 Smith-Waterman score: 7510; 99.6% identity (99.8% similar) in 1117 aa overlap (29-1145:190-1306) 10 20 30 40 50 pF1KB4 MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTDAYLNASETTTLSPSGSAVISTTTI : . .::::::::::::::::::::::::: NP_002 TDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTI 160 170 180 190 200 210 60 70 80 90 100 110 pF1KB4 ATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNA 220 230 240 250 260 270 120 130 140 150 160 170 pF1KB4 SVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNIT 280 290 300 310 320 330 180 190 200 210 220 230 pF1KB4 YRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 YRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIF 340 350 360 370 380 390 240 250 260 270 280 290 pF1KB4 CRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 CRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSL 400 410 420 430 440 450 300 310 320 330 340 350 pF1KB4 HAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 HAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYH 460 470 480 490 500 510 360 370 380 390 400 410 pF1KB4 LEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKAL 520 530 540 550 560 570 420 430 440 450 460 470 pF1KB4 IAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILL 580 590 600 610 620 630 480 490 500 510 520 530 pF1KB4 ETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEI 640 650 660 670 680 690 540 550 560 570 580 590 pF1KB4 NGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNR 700 710 720 730 740 750 600 610 620 630 640 650 pF1KB4 NKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSW 760 770 780 790 800 810 660 670 680 690 700 710 pF1KB4 PDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKV 820 830 840 850 860 870 720 730 740 750 760 770 pF1KB4 DVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPS 880 890 900 910 920 930 780 790 800 810 820 830 pF1KB4 EPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEH 940 950 960 970 980 990 840 850 860 870 880 890 pF1KB4 DSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIV 1000 1010 1020 1030 1040 1050 900 910 920 930 940 950 pF1KB4 MLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQ 1060 1070 1080 1090 1100 1110 960 970 980 990 1000 1010 pF1KB4 YQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 YQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIF 1120 1130 1140 1150 1160 1170 1020 1030 1040 1050 1060 1070 pF1KB4 CALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 CALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKN 1180 1190 1200 1210 1220 1230 1080 1090 1100 1110 1120 1130 pF1KB4 NHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPAS 1240 1250 1260 1270 1280 1290 1140 pF1KB4 PALNQGS ::::::: NP_002 PALNQGS 1300 >-- initn: 297 init1: 222 opt: 234 Z-score: 225.4 bits: 53.8 E(85289): 8.2e-06 Smith-Waterman score: 234; 63.5% identity (79.4% similar) in 63 aa overlap (1-63:1-60) 10 20 30 40 50 60 pF1KB4 MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTDAYLNASETTTLSPSGSAVISTTTIAT ::::::::::::::::::::::::::::::::: :.... .. : .: . : : : NP_002 MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTG--LTTAKMPSV-PLSSDPLPTHTTAF 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 TPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASV .:. NP_002 SPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQT 60 70 80 90 100 110 >>NP_543031 (OMIM: 176884) receptor-type tyrosine-protei (793 aa) initn: 1453 init1: 490 opt: 1069 Z-score: 1035.3 bits: 202.9 E(85289): 6.3e-51 Smith-Waterman score: 1607; 39.9% identity (69.6% similar) in 667 aa overlap (418-1064:147-779) 390 400 410 420 430 440 pF1KB4 DYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVL-YKIYD---- ..:. ..:.:: : .: .: .: : NP_543 RTEPWEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGS 120 130 140 150 160 170 450 460 470 480 490 pF1KB4 ------LHKKRSCNLDEQQ-ELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAE : . :. ... :. :. :. . . :. .: : : .:..::...:: : NP_543 HSNSFRLSNGRTEDVEPQSVPLLARSPSTN-RKYPPLPVDKLEEEINRRMADDNKLFREE 180 190 200 210 220 230 500 510 520 530 540 550 pF1KB4 FQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGF :...: . . : : :..:::::.:::::..::.:. ..: :.:::::.:.:. NP_543 FNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGY 240 250 260 270 280 290 560 570 580 590 600 610 pF1KB4 KEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAF .: :.::::::..:::.:::::::::....::::: .: .. :::.::: ..: .. NP_543 QEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWP--DQGCWTY 300 310 320 330 340 350 620 630 640 650 660 pF1KB4 GDVVVKINQHKRCPDYIIQKL------NIVNKKEKATGREVTHIQFTSWPDHGVPEDPHL :.. :.... :: ..:. ...:.: . : .:...:::::: ::: : NP_543 GNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQ---RLITQFHFTSWPDFGVPFTPIG 360 370 380 390 400 410 670 680 690 700 710 720 pF1KB4 LLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRR .::. ..:.: . ..: ::::::::::::::.. :::::. ...: ::::::.: ..: NP_543 MLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRA 420 430 440 450 460 470 730 740 750 760 770 780 pF1KB4 QRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQR ::: :::.. ::..:.:::.:. .:.::.... :. .:... .. : . . :: ::.. NP_543 QRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKK 480 490 500 510 520 530 790 800 810 820 830 840 pF1KB4 LPSYRSWRTQ-HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDS : : . . . :: : .::: ..:::..::: . :..:...: NP_543 LTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIP-----VKRGEENTD------- 540 550 560 570 850 860 870 880 890 900 pF1KB4 DSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQ :.::::: .: . . .::.:::: .:: :::.::.. : :::::::.. : NP_543 -------YVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQ 580 590 600 610 620 630 910 920 930 940 950 960 pF1KB4 EICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVE : ::::: ..: .:::: :.:: .. .::.: . . ..... :: . :... .: NP_543 EKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEV 640 650 660 670 680 690 970 980 990 1000 1010 1020 pF1KB4 QLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLES .:.. : .::.: .: ::.......: :. .:: :. .:: :::: ..:: NP_543 GIPSDGKGMISIIAAV-----QKQQQQSGNH----PITVHCSAGAGRTGTFCALSTVLER 700 710 720 730 740 1030 1040 1050 1060 1070 1080 pF1KB4 AETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEF ...: ..:.::.::.:: :: ::.:.:::.: : :. NP_543 VKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK 750 760 770 780 790 1090 1100 1110 1120 1130 1140 pF1KB4 DNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS >>NP_543030 (OMIM: 176884) receptor-type tyrosine-protei (793 aa) initn: 1453 init1: 490 opt: 1069 Z-score: 1035.3 bits: 202.9 E(85289): 6.3e-51 Smith-Waterman score: 1607; 39.9% identity (69.6% similar) in 667 aa overlap (418-1064:147-779) 390 400 410 420 430 440 pF1KB4 DYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVL-YKIYD---- ..:. ..:.:: : .: .: .: : NP_543 RTEPWEGNSSTAATTPETFPPSDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGS 120 130 140 150 160 170 450 460 470 480 490 pF1KB4 ------LHKKRSCNLDEQQ-ELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAE : . :. ... :. :. :. . . :. .: : : .:..::...:: : NP_543 HSNSFRLSNGRTEDVEPQSVPLLARSPSTN-RKYPPLPVDKLEEEINRRMADDNKLFREE 180 190 200 210 220 230 500 510 520 530 540 550 pF1KB4 FQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGF :...: . . : : :..:::::.:::::..::.:. ..: :.:::::.:.:. NP_543 FNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGY 240 250 260 270 280 290 560 570 580 590 600 610 pF1KB4 KEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAF .: :.::::::..:::.:::::::::....::::: .: .. :::.::: ..: .. NP_543 QEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWP--DQGCWTY 300 310 320 330 340 350 620 630 640 650 660 pF1KB4 GDVVVKINQHKRCPDYIIQKL------NIVNKKEKATGREVTHIQFTSWPDHGVPEDPHL :.. :.... :: ..:. ...:.: . : .:...:::::: ::: : NP_543 GNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQ---RLITQFHFTSWPDFGVPFTPIG 360 370 380 390 400 410 670 680 690 700 710 720 pF1KB4 LLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRR .::. ..:.: . ..: ::::::::::::::.. :::::. ...: ::::::.: ..: NP_543 MLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRA 420 430 440 450 460 470 730 740 750 760 770 780 pF1KB4 QRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQR ::: :::.. ::..:.:::.:. .:.::.... :. .:... .. : . . :: ::.. NP_543 QRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKK 480 490 500 510 520 530 790 800 810 820 830 840 pF1KB4 LPSYRSWRTQ-HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDS : : . . . :: : .::: ..:::..::: . :..:...: NP_543 LTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIP-----VKRGEENTD------- 540 550 560 570 850 860 870 880 890 900 pF1KB4 DSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQ :.::::: .: . . .::.:::: .:: :::.::.. : :::::::.. : NP_543 -------YVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQ 580 590 600 610 620 630 910 920 930 940 950 960 pF1KB4 EICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVE : ::::: ..: .:::: :.:: .. .::.: . . ..... :: . :... .: NP_543 EKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEV 640 650 660 670 680 690 970 980 990 1000 1010 1020 pF1KB4 QLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLES .:.. : .::.: .: ::.......: :. .:: :. .:: :::: ..:: NP_543 GIPSDGKGMISIIAAV-----QKQQQQSGNH----PITVHCSAGAGRTGTFCALSTVLER 700 710 720 730 740 1030 1040 1050 1060 1070 1080 pF1KB4 AETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEF ...: ..:.::.::.:: :: ::.:.:::.: : :. NP_543 VKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK 750 760 770 780 790 1090 1100 1110 1120 1130 1140 pF1KB4 DNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS >>NP_002827 (OMIM: 176884) receptor-type tyrosine-protei (802 aa) initn: 1453 init1: 490 opt: 1069 Z-score: 1035.2 bits: 202.9 E(85289): 6.3e-51 Smith-Waterman score: 1607; 39.9% identity (69.6% similar) in 667 aa overlap (418-1064:156-788) 390 400 410 420 430 440 pF1KB4 DYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVL-YKIYD---- ..:. ..:.:: : .: .: .: : NP_002 STAATTPETFPPSGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGS 130 140 150 160 170 180 450 460 470 480 490 pF1KB4 ------LHKKRSCNLDEQQ-ELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAE : . :. ... :. :. :. . . :. .: : : .:..::...:: : NP_002 HSNSFRLSNGRTEDVEPQSVPLLARSPSTN-RKYPPLPVDKLEEEINRRMADDNKLFREE 190 200 210 220 230 240 500 510 520 530 540 550 pF1KB4 FQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGF :...: . . : : :..:::::.:::::..::.:. ..: :.:::::.:.:. NP_002 FNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGY 250 260 270 280 290 300 560 570 580 590 600 610 pF1KB4 KEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAF .: :.::::::..:::.:::::::::....::::: .: .. :::.::: ..: .. NP_002 QEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWP--DQGCWTY 310 320 330 340 350 360 620 630 640 650 660 pF1KB4 GDVVVKINQHKRCPDYIIQKL------NIVNKKEKATGREVTHIQFTSWPDHGVPEDPHL :.. :.... :: ..:. ...:.: . : .:...:::::: ::: : NP_002 GNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQ---RLITQFHFTSWPDFGVPFTPIG 370 380 390 400 410 670 680 690 700 710 720 pF1KB4 LLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRR .::. ..:.: . ..: ::::::::::::::.. :::::. ...: ::::::.: ..: NP_002 MLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRA 420 430 440 450 460 470 730 740 750 760 770 780 pF1KB4 QRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQR ::: :::.. ::..:.:::.:. .:.::.... :. .:... .. : . . :: ::.. NP_002 QRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKK 480 490 500 510 520 530 790 800 810 820 830 840 pF1KB4 LPSYRSWRTQ-HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDS : : . . . :: : .::: ..:::..::: . :..:...: NP_002 LTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIP-----VKRGEENTD------- 540 550 560 570 580 850 860 870 880 890 900 pF1KB4 DSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQ :.::::: .: . . .::.:::: .:: :::.::.. : :::::::.. : NP_002 -------YVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQ 590 600 610 620 630 640 910 920 930 940 950 960 pF1KB4 EICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVE : ::::: ..: .:::: :.:: .. .::.: . . ..... :: . :... .: NP_002 EKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEV 650 660 670 680 690 700 970 980 990 1000 1010 1020 pF1KB4 QLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLES .:.. : .::.: .: ::.......: :. .:: :. .:: :::: ..:: NP_002 GIPSDGKGMISIIAAV-----QKQQQQSGNH----PITVHCSAGAGRTGTFCALSTVLER 710 720 730 740 750 1030 1040 1050 1060 1070 1080 pF1KB4 AETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEF ...: ..:.::.::.:: :: ::.:.:::.: : :. NP_002 VKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK 760 770 780 790 800 1090 1100 1110 1120 1130 1140 pF1KB4 DNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS >>XP_011538298 (OMIM: 600926) PREDICTED: receptor-type t (678 aa) initn: 1280 init1: 850 opt: 996 Z-score: 965.8 bits: 189.9 E(85289): 4.7e-47 Smith-Waterman score: 1339; 37.1% identity (65.3% similar) in 668 aa overlap (415-1064:64-664) 390 400 410 420 430 440 pF1KB4 YSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLH :. :.:.: . ... ..::.. : .. .. XP_011 LPLARALRGNETTADSNETTTTSGPPDPGASQPLLAWLLLPLLLLLLVLLLAAY-FFRFR 40 50 60 70 80 90 450 460 470 480 pF1KB4 KKRSCNLDEQQE-----LVERDDEKQLMNVE----------PIHADILLETYKRKIADEG :.:. .. ... ..:.......: . :: .. : : . . ::. XP_011 KQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDC 100 110 120 130 140 150 490 500 510 520 530 540 pF1KB4 RLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINA . : ::.:.: . .. : : :..:::: .::: :..:: ::...: :.:::: XP_011 KQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINA 160 170 180 190 200 210 550 560 570 580 590 600 pF1KB4 SYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSME :::::.:: :.::::::..:::.:::::.::::...:::.: .: ...:: .::: . XP_011 SYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWP--D 220 230 240 250 260 270 610 620 630 640 650 660 pF1KB4 EGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA--TGREVTHIQFTSWPDHGVPEDP .: ..:.. : ... :: :.:. : . . . : :....:::::: ::: : XP_011 QGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTP 280 290 300 310 320 330 670 680 690 700 710 720 pF1KB4 HLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKL .::. ..:.... .::::::::::::::::.: ::::. ..::.::::. .: .. XP_011 IGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRI 340 350 360 370 380 390 730 740 750 760 770 780 pF1KB4 RRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEF : :: :::.. :: .:.:::.:: .:.::...: :. .:..:. . :: :: XP_011 RNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEF 400 410 420 430 440 450 790 800 810 820 830 840 pF1KB4 QRLPSYRSWR-TQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDD ..: . : . ... :: : .: : ..::::.::: :. :.. .:. XP_011 RKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILS----MKRGQEY-------- 460 470 480 490 850 860 870 880 890 900 pF1KB4 DSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHG . ::::::: .: . . .::.:::: .:. :::.::.. : ..::::::... XP_011 -------TDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQER 500 510 520 530 540 550 910 920 930 940 950 960 pF1KB4 DQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSV .: ...: ... :.: :... .: XP_011 EQP-------QARQ-----------------------------EEQVRVVRQFHFHGWPE 560 570 970 980 990 1000 1010 1020 pF1KB4 EQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLE .::: : .:..: .: :: :.. ::. :. .:: :. .:: : :: :.:: XP_011 IGIPAEGKGMIDLIAAV-QKQQQQT---GNH-----PITVHCSAGAGRTGTFIALSNILE 580 590 600 610 620 1030 1040 1050 1060 1070 1080 pF1KB4 SAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIE ...: ..:.::.::.:: :: ::.:.:::.: : :. XP_011 RVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK 630 640 650 660 670 1090 1100 1110 1120 1130 1140 pF1KB4 FDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS >>XP_011538296 (OMIM: 600926) PREDICTED: receptor-type t (719 aa) initn: 1304 init1: 461 opt: 993 Z-score: 962.5 bits: 189.3 E(85289): 7.1e-47 Smith-Waterman score: 1486; 39.0% identity (68.1% similar) in 674 aa overlap (415-1064:64-705) 390 400 410 420 430 440 pF1KB4 YSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLH :. :.:.: . ... ..::.. : .. .. XP_011 LPLARALRGNETTADSNETTTTSGPPDPGASQPLLAWLLLPLLLLLLVLLLAAY-FFRFR 40 50 60 70 80 90 450 460 470 480 pF1KB4 KKRSCNLDEQQE-----LVERDDEKQLMNVE----------PIHADILLETYKRKIADEG :.:. .. ... ..:.......: . :: .. : : . . ::. XP_011 KQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDC 100 110 120 130 140 150 490 500 510 520 530 540 pF1KB4 RLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINA . : ::.:.: . .. : : :..:::: .::: :..:: ::...: :.:::: XP_011 KQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINA 160 170 180 190 200 210 550 560 570 580 590 600 pF1KB4 SYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSME :::::.:: :.::::::..:::.:::::.::::...:::.: .: ...:: .::: . XP_011 SYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWP--D 220 230 240 250 260 270 610 620 630 640 650 660 pF1KB4 EGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKE--KATGREVTHIQFTSWPDHGVPEDP .: ..:.. : ... :: :.:. : . :: : :....:::::: ::: : XP_011 QGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPLPDGCKAP-RLVSQLHFTSWPDFGVPFTP 280 290 300 310 320 670 680 690 700 710 720 pF1KB4 HLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKL .::. ..:.... .::::::::::::::::.: ::::. ..::.::::. .: .. XP_011 IGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRI 330 340 350 360 370 380 730 740 750 760 770 780 pF1KB4 RRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEF : :: :::.. :: .:.:::.:: .:.::...: :. .:..:. . :: :: XP_011 RNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEF 390 400 410 420 430 440 790 800 810 820 830 840 pF1KB4 QRLPSYRSWR-TQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDD ..: . : . ... :: : .: : ..::::.::: :. :.. .:. XP_011 RKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILS----MKRGQEY-------- 450 460 470 480 490 850 860 870 880 890 900 pF1KB4 DSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHG . ::::::: .: . . .::.:::: .:. :::.::.. : ..::::::... XP_011 -------TDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQER 500 510 520 530 540 550 910 920 930 940 950 960 pF1KB4 DQEICAQYWG-EGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSK---RKDS--RTVYQYQ .:. : ::: ::. :.:.: ...:. : . ..: : . .. :.. :.: :.. XP_011 EQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFH 560 570 580 590 600 610 970 980 990 1000 1010 1020 pF1KB4 YTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCA . .: .::: : .:..: .: :: :.. ::. :. .:: :. .:: : : XP_011 FHGWPEIGIPAEGKGMIDLIAAV-QKQQQQT---GNH-----PITVHCSAGAGRTGTFIA 620 630 640 650 660 1030 1040 1050 1060 1070 1080 pF1KB4 LLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNH : :.:: ...: ..:.::.::.:: :: ::.:.:::.: : :. XP_011 LSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK 670 680 690 700 710 1090 1100 1110 1120 1130 1140 pF1KB4 QEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPA 1145 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 07:13:29 2016 done: Sat Nov 5 07:13:31 2016 Total Scan time: 10.800 Total Display time: 0.470 Function used was FASTA [36.3.4 Apr, 2011]