Result of FASTA (omim) for
pF1KB4745
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4745, 373 aa
1>>>pF1KB4745 373 - 373 aa - 373 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4688+/-0.000462; mu= 15.6838+/- 0.028
mean_var=71.2497+/-14.777, 0's: 0 Z-trim(109.0): 29 B-trim: 0 in 0/51
Lambda= 0.151944
statistics sampled from 17128 (17146) to 17128 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.558), E-opt: 0.2 (0.201), width: 16
Scan time: 8.210
The best scores are: opt bits E(85289)
NP_116186 (OMIM: 605159) apoptosis-inducing factor ( 373) 2365 528.1 1.2e-149
NP_001185625 (OMIM: 605159) apoptosis-inducing fac ( 373) 2365 528.1 1.2e-149
NP_001276679 (OMIM: 238331,246900) dihydrolipoyl d ( 410) 149 42.4 0.0023
NP_001276680 (OMIM: 238331,246900) dihydrolipoyl d ( 486) 149 42.4 0.0026
NP_000099 (OMIM: 238331,246900) dihydrolipoyl dehy ( 509) 149 42.4 0.0027
NP_665811 (OMIM: 300169,300614,310490) apoptosis-i ( 609) 143 41.2 0.0079
NP_004199 (OMIM: 300169,300614,310490) apoptosis-i ( 613) 143 41.2 0.0079
>>NP_116186 (OMIM: 605159) apoptosis-inducing factor 2 [ (373 aa)
initn: 2365 init1: 2365 opt: 2365 Z-score: 2807.4 bits: 528.1 E(85289): 1.2e-149
Smith-Waterman score: 2365; 100.0% identity (100.0% similar) in 373 aa overlap (1-373:1-373)
10 20 30 40 50 60
pF1KB4 MGSQVSVESGALHVVIVGGGFGGIAAASQLQALNVPFMLVDMKDSFHHNVAALRASVETG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 MGSQVSVESGALHVVIVGGGFGGIAAASQLQALNVPFMLVDMKDSFHHNVAALRASVETG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 FAKKTFISYSVTFKDNFRQGLVVGIDLKNQMVLLQGGEALPFSHLILATGSTGPFPGKFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 FAKKTFISYSVTFKDNFRQGLVVGIDLKNQMVLLQGGEALPFSHLILATGSTGPFPGKFN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 EVSSQQAAIQAYEDMVRQVQRSRFIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSQVALA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 EVSSQQAAIQAYEDMVRQVQRSRFIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSQVALA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 DKELLPSVRQEVKEILLRKGVQLLLSERVSNLEELPLNEYREYIKVQTDKGTEVATNLVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 DKELLPSVRQEVKEILLRKGVQLLLSERVSNLEELPLNEYREYIKVQTDKGTEVATNLVI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 LCTGIKINSSAYRKAFESRLASSGALRVNEHLQVEGHSNVYAIGDCADVRTPKMAYLAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 LCTGIKINSSAYRKAFESRLASSGALRVNEHLQVEGHSNVYAIGDCADVRTPKMAYLAGL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 HANIAVANIVNSVKQRPLQAYKPGALTFLLSMGRNDGVGQISGFYVGRLMVRLTKSRDLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 HANIAVANIVNSVKQRPLQAYKPGALTFLLSMGRNDGVGQISGFYVGRLMVRLTKSRDLF
310 320 330 340 350 360
370
pF1KB4 VSTSWKTMRQSPP
:::::::::::::
NP_116 VSTSWKTMRQSPP
370
>>NP_001185625 (OMIM: 605159) apoptosis-inducing factor (373 aa)
initn: 2365 init1: 2365 opt: 2365 Z-score: 2807.4 bits: 528.1 E(85289): 1.2e-149
Smith-Waterman score: 2365; 100.0% identity (100.0% similar) in 373 aa overlap (1-373:1-373)
10 20 30 40 50 60
pF1KB4 MGSQVSVESGALHVVIVGGGFGGIAAASQLQALNVPFMLVDMKDSFHHNVAALRASVETG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGSQVSVESGALHVVIVGGGFGGIAAASQLQALNVPFMLVDMKDSFHHNVAALRASVETG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 FAKKTFISYSVTFKDNFRQGLVVGIDLKNQMVLLQGGEALPFSHLILATGSTGPFPGKFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAKKTFISYSVTFKDNFRQGLVVGIDLKNQMVLLQGGEALPFSHLILATGSTGPFPGKFN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 EVSSQQAAIQAYEDMVRQVQRSRFIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSQVALA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVSSQQAAIQAYEDMVRQVQRSRFIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSQVALA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 DKELLPSVRQEVKEILLRKGVQLLLSERVSNLEELPLNEYREYIKVQTDKGTEVATNLVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKELLPSVRQEVKEILLRKGVQLLLSERVSNLEELPLNEYREYIKVQTDKGTEVATNLVI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 LCTGIKINSSAYRKAFESRLASSGALRVNEHLQVEGHSNVYAIGDCADVRTPKMAYLAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCTGIKINSSAYRKAFESRLASSGALRVNEHLQVEGHSNVYAIGDCADVRTPKMAYLAGL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 HANIAVANIVNSVKQRPLQAYKPGALTFLLSMGRNDGVGQISGFYVGRLMVRLTKSRDLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HANIAVANIVNSVKQRPLQAYKPGALTFLLSMGRNDGVGQISGFYVGRLMVRLTKSRDLF
310 320 330 340 350 360
370
pF1KB4 VSTSWKTMRQSPP
:::::::::::::
NP_001 VSTSWKTMRQSPP
370
>>NP_001276679 (OMIM: 238331,246900) dihydrolipoyl dehyd (410 aa)
initn: 108 init1: 52 opt: 149 Z-score: 181.5 bits: 42.4 E(85289): 0.0023
Smith-Waterman score: 149; 22.2% identity (57.7% similar) in 234 aa overlap (77-298:43-267)
50 60 70 80 90
pF1KB4 HHNVAALRASVETGFAKKTFISYSVTFKDNFRQGLVVGIDL------KNQMVLLQ--GG-
:.:. :: .. :::.. . ::
NP_001 EMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGT
20 30 40 50 60 70
100 110 120 130 140 150
pF1KB4 EALPFSHLILATGS-TGPFPGKFNEVSSQQAAIQAYEDMVRQVQRSRFIVVVGGGSAGVE
... .....:::: . :::: .. .. .: . . . . .::.:.: :::
NP_001 QVIDTKNILIATGSEVTPFPG----ITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVE
80 90 100 110 120
160 170 180 190 200 210
pF1KB4 MAAEIKTEYPEKEVTLIHSQVALADKELLPSVRQEVKEILLRKGVQLLLSERVSNLEELP
... . . .. . ..:. . .. . .. ..:: ..: .. :. .:.. .
NP_001 LGSVWQRLGADVTAVEFLGHVGGVGIDM--EISKNFQRILQKQGFKFKLNTKVTGATKKS
130 140 150 160 170 180
220 230 240 250 260 270
pF1KB4 LNEYREYIKVQTDKGTEVAT-NLVILCTGIK-INSSAYRKAFESRLASSGALRVNEHLQV
.. :.. . .:: : .....: : . .... . . .: : . :: ..:.
NP_001 DGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQT
190 200 210 220 230 240
280 290 300 310 320 330
pF1KB4 EGHSNVYAIGDCADVRTPKMAYLAGLHANIAVANIVNSVKQRPLQAYKPGALTFLLSMGR
. :.::::: : : .:. :
NP_001 KI-PNIYAIGDV--VAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWV
250 260 270 280 290 300
>>NP_001276680 (OMIM: 238331,246900) dihydrolipoyl dehyd (486 aa)
initn: 108 init1: 52 opt: 149 Z-score: 180.4 bits: 42.4 E(85289): 0.0026
Smith-Waterman score: 167; 20.9% identity (56.3% similar) in 311 aa overlap (14-298:44-343)
10 20 30 40
pF1KB4 MGSQVSVESGALHVVIVGGGFGGIAAASQLQALNVPFMLVDMK
:...:.: :: .:: ..: .. : . .
NP_001 RGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAA--IKAAQLGFKALLNN
20 30 40 50 60 70
50 60 70 80
pF1KB4 DSFHH------------NVAALRASVETGFAKKTFISYSVT--FKDNFRQGLVVGIDL--
. ..: ... .: ... . .:. ..: . :.:. :: ..
NP_001 SHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYG
80 90 100 110 120 130
90 100 110 120 130
pF1KB4 ----KNQMVLLQ--GG-EALPFSHLILATGS-TGPFPGKFNEVSSQQAAIQAYEDMVRQV
:::.. . :: ... .....:::: . :::: .. .. .: . .
NP_001 KITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPG----ITIDEDTIVSSTGALSLK
140 150 160 170 180
140 150 160 170 180 190
pF1KB4 QRSRFIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSQVALADKELLPSVRQEVKEILLRK
. . .::.:.: :::... . . .. . ..:. . .. . .. ..:: ..
NP_001 KVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDM--EISKNFQRILQKQ
190 200 210 220 230 240
200 210 220 230 240 250
pF1KB4 GVQLLLSERVSNLEELPLNEYREYIKVQTDKGTEVAT-NLVILCTGIK-INSSAYRKAFE
: .. :. .:.. . .. :.. . .:: : .....: : . .... . .
NP_001 GFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELG
250 260 270 280 290 300
260 270 280 290 300 310
pF1KB4 SRLASSGALRVNEHLQVEGHSNVYAIGDCADVRTPKMAYLAGLHANIAVANIVNSVKQRP
.: : . :: ..:.. :.::::: : : .:. :
NP_001 IELDPRGRIPVNTRFQTKI-PNIYAIGDV--VAGPMLAHKAEDEGIICVEGMAGGAVHID
310 320 330 340 350 360
320 330 340 350 360 370
pF1KB4 LQAYKPGALTFLLSMGRNDGVGQISGFYVGRLMVRLTKSRDLFVSTSWKTMRQSPP
NP_001 YNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQK
370 380 390 400 410 420
>>NP_000099 (OMIM: 238331,246900) dihydrolipoyl dehydrog (509 aa)
initn: 108 init1: 52 opt: 149 Z-score: 180.1 bits: 42.4 E(85289): 0.0027
Smith-Waterman score: 149; 22.2% identity (57.7% similar) in 234 aa overlap (77-298:142-366)
50 60 70 80 90
pF1KB4 HHNVAALRASVETGFAKKTFISYSVTFKDNFRQGLVVGIDL------KNQMVLLQ--GG-
:.:. :: .. :::.. . ::
NP_000 EMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGT
120 130 140 150 160 170
100 110 120 130 140 150
pF1KB4 EALPFSHLILATGS-TGPFPGKFNEVSSQQAAIQAYEDMVRQVQRSRFIVVVGGGSAGVE
... .....:::: . :::: .. .. .: . . . . .::.:.: :::
NP_000 QVIDTKNILIATGSEVTPFPG----ITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVE
180 190 200 210 220
160 170 180 190 200 210
pF1KB4 MAAEIKTEYPEKEVTLIHSQVALADKELLPSVRQEVKEILLRKGVQLLLSERVSNLEELP
... . . .. . ..:. . .. . .. ..:: ..: .. :. .:.. .
NP_000 LGSVWQRLGADVTAVEFLGHVGGVGIDM--EISKNFQRILQKQGFKFKLNTKVTGATKKS
230 240 250 260 270 280
220 230 240 250 260 270
pF1KB4 LNEYREYIKVQTDKGTEVAT-NLVILCTGIK-INSSAYRKAFESRLASSGALRVNEHLQV
.. :.. . .:: : .....: : . .... . . .: : . :: ..:.
NP_000 DGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQT
290 300 310 320 330 340
280 290 300 310 320 330
pF1KB4 EGHSNVYAIGDCADVRTPKMAYLAGLHANIAVANIVNSVKQRPLQAYKPGALTFLLSMGR
. :.::::: : : .:. :
NP_000 KI-PNIYAIGDV--VAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWV
350 360 370 380 390 400
>>NP_665811 (OMIM: 300169,300614,310490) apoptosis-induc (609 aa)
initn: 109 init1: 72 opt: 143 Z-score: 171.8 bits: 41.2 E(85289): 0.0079
Smith-Waterman score: 172; 21.9% identity (52.8% similar) in 352 aa overlap (2-308:116-457)
10 20
pF1KB4 MGSQVSVESGALHV--VIVGGGFGGIAAASQ
: .: ... :: ...::: ...::: .
NP_665 EDEKRYNERISGLGLTPEQKQKKAALSASEGEEVPQDKAPSHVPFLLIGGGTAAFAAARS
90 100 110 120 130 140
30 40 50 60
pF1KB4 LQALN-------------VPFMLVDMKDSF----HHNVA-ALRASVETGFAKKTFI---S
..: . .:.: .. . ::. .:: . .: .. .. :
NP_665 IRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLRFKQWNGKERSIYFQPPS
150 160 170 180 190 200
70 80 90 100 110
pF1KB4 YSVTFKD--NFRQG--------LVVGIDLKNQMVLLQGGEALPFSHLILATGSTGPFPGK
. :. .: ....: :: .:....:: :. : . . . ..:::.: : .
NP_665 FYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGT---PRS
210 220 230 240 250 260
120 130 140 150 160
pF1KB4 FNEVSSQQAAIQAYEDMVRQVQ--RS--------RFIVVVGGGSAGVEMAAEI--KTEYP
.. .. : ... . :.. :: . :...::: : :.: . :..
NP_665 LSAIDRAGAEVKSRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARAL
270 280 290 300 310 320
170 180 190 200 210 220
pF1KB4 EKEVTLIHSQVALADKELLPSVRQEVKEILLRKGVQLLLSERVSNLEELPLNEYREYIKV
:: . . . : : . . . : . :.::... . :... .. . ::.
NP_665 GTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSV---GVSSGKLLIKL
330 340 350 360 370
230 240 250 260 270 280
pF1KB4 QTDKGTEVATNLVILCTGIKINSSAYRKAFESRLASSGALRVNEHLQVEGHSNVYAIGDC
. : .: :. .. .:.. : . . .. :..::: .::.. ::... ::
NP_665 KD--GRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQAR--SNIWVAGDA
380 390 400 410 420 430
290 300 310 320 330 340
pF1KB4 ADVRTPKMAYLAGLHANIAVANIVNSVKQRPLQAYKPGALTFLLSMGRNDGVGQISGFYV
: :.. : . ::..
NP_665 ACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVD
440 450 460 470 480 490
>>NP_004199 (OMIM: 300169,300614,310490) apoptosis-induc (613 aa)
initn: 109 init1: 72 opt: 143 Z-score: 171.8 bits: 41.2 E(85289): 0.0079
Smith-Waterman score: 172; 21.9% identity (52.8% similar) in 352 aa overlap (2-308:120-461)
10 20
pF1KB4 MGSQVSVESGALHV--VIVGGGFGGIAAASQ
: .: ... :: ...::: ...::: .
NP_004 EDEKRYNERISGLGLTPEQKQKKAALSASEGEEVPQDKAPSHVPFLLIGGGTAAFAAARS
90 100 110 120 130 140
30 40 50 60
pF1KB4 LQALN-------------VPFMLVDMKDSF----HHNVA-ALRASVETGFAKKTFI---S
..: . .:.: .. . ::. .:: . .: .. .. :
NP_004 IRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLRFKQWNGKERSIYFQPPS
150 160 170 180 190 200
70 80 90 100 110
pF1KB4 YSVTFKD--NFRQG--------LVVGIDLKNQMVLLQGGEALPFSHLILATGSTGPFPGK
. :. .: ....: :: .:....:: :. : . . . ..:::.: : .
NP_004 FYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGT---PRS
210 220 230 240 250 260
120 130 140 150 160
pF1KB4 FNEVSSQQAAIQAYEDMVRQVQ--RS--------RFIVVVGGGSAGVEMAAEI--KTEYP
.. .. : ... . :.. :: . :...::: : :.: . :..
NP_004 LSAIDRAGAEVKSRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARAL
270 280 290 300 310 320
170 180 190 200 210 220
pF1KB4 EKEVTLIHSQVALADKELLPSVRQEVKEILLRKGVQLLLSERVSNLEELPLNEYREYIKV
:: . . . : : . . . : . :.::... . :... .. . ::.
NP_004 GTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSV---GVSSGKLLIKL
330 340 350 360 370 380
230 240 250 260 270 280
pF1KB4 QTDKGTEVATNLVILCTGIKINSSAYRKAFESRLASSGALRVNEHLQVEGHSNVYAIGDC
. : .: :. .. .:.. : . . .. :..::: .::.. ::... ::
NP_004 KD--GRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQAR--SNIWVAGDA
390 400 410 420 430
290 300 310 320 330 340
pF1KB4 ADVRTPKMAYLAGLHANIAVANIVNSVKQRPLQAYKPGALTFLLSMGRNDGVGQISGFYV
: :.. : . ::..
NP_004 ACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVD
440 450 460 470 480 490
373 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 15:28:15 2016 done: Thu Nov 3 15:28:16 2016
Total Scan time: 8.210 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]