FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4802, 1172 aa 1>>>pF1KB4802 1172 - 1172 aa - 1172 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.2192+/-0.000521; mu= 9.7722+/- 0.032 mean_var=273.6278+/-54.184, 0's: 0 Z-trim(116.6): 292 B-trim: 104 in 2/53 Lambda= 0.077534 statistics sampled from 27641 (27959) to 27641 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.666), E-opt: 0.2 (0.328), width: 16 Scan time: 16.350 The best scores are: opt bits E(85289) XP_005273181 (OMIM: 104530,150310,226650,226700) P (1172) 8180 930.2 0 NP_000219 (OMIM: 104530,150310,226650,226700) lami (1172) 8180 930.2 0 NP_001121113 (OMIM: 104530,150310,226650,226700) l (1172) 8180 930.2 0 NP_001017402 (OMIM: 104530,150310,226650,226700) l (1172) 8180 930.2 0 XP_016856761 (OMIM: 104530,150310,226650,226700) P (1108) 6812 777.2 0 NP_002283 (OMIM: 150325,609049,614199) laminin sub (1798) 1258 156.2 1.7e-36 XP_005265184 (OMIM: 150325,609049,614199) PREDICTE (1798) 1258 156.2 1.7e-36 NP_001304977 (OMIM: 616380) laminin subunit beta-4 ( 772) 1251 155.0 1.7e-36 NP_001304976 (OMIM: 616380) laminin subunit beta-4 (1101) 1251 155.1 2.2e-36 XP_011514282 (OMIM: 616380) PREDICTED: laminin sub (1564) 1251 155.3 2.7e-36 XP_016867369 (OMIM: 616380) PREDICTED: laminin sub (1567) 1251 155.3 2.7e-36 XP_011514281 (OMIM: 616380) PREDICTED: laminin sub (1703) 1251 155.4 2.9e-36 XP_011514280 (OMIM: 616380) PREDICTED: laminin sub (1723) 1251 155.4 2.9e-36 XP_016867368 (OMIM: 616380) PREDICTED: laminin sub (1753) 1251 155.4 2.9e-36 NP_001304975 (OMIM: 616380) laminin subunit beta-4 (1761) 1251 155.4 2.9e-36 NP_031382 (OMIM: 616380) laminin subunit beta-4 is (1761) 1251 155.4 2.9e-36 XP_011514277 (OMIM: 616380) PREDICTED: laminin sub (1772) 1251 155.4 3e-36 XP_016867691 (OMIM: 150240,615191) PREDICTED: lami (1212) 1119 140.4 6.5e-32 NP_002282 (OMIM: 150240,615191) laminin subunit be (1786) 1119 140.6 8.3e-32 XP_016867690 (OMIM: 150240,615191) PREDICTED: lami (1810) 1119 140.6 8.3e-32 NP_001316629 (OMIM: 610401) netrin-4 isoform 2 pre ( 605) 1007 127.5 2.5e-28 NP_067052 (OMIM: 610401) netrin-4 isoform 1 precur ( 628) 1007 127.6 2.5e-28 NP_001316630 (OMIM: 610401) netrin-4 isoform 3 [Ho ( 591) 974 123.8 3.1e-27 NP_001316631 (OMIM: 610401) netrin-4 isoform 3 [Ho ( 591) 974 123.8 3.1e-27 XP_011516423 (OMIM: 604349,614115) PREDICTED: lami (1581) 841 109.5 1.8e-22 NP_006050 (OMIM: 604349,614115) laminin subunit ga (1575) 827 107.9 5.2e-22 XP_006716984 (OMIM: 604349,614115) PREDICTED: lami (1259) 823 107.3 6.1e-22 XP_006723861 (OMIM: 601033) PREDICTED: laminin sub (2300) 823 107.7 9e-22 XP_011527121 (OMIM: 601033) PREDICTED: laminin sub (3609) 823 107.9 1.2e-21 XP_011527120 (OMIM: 601033) PREDICTED: laminin sub (3654) 823 107.9 1.2e-21 NP_005551 (OMIM: 601033) laminin subunit alpha-5 p (3695) 823 107.9 1.2e-21 XP_006723859 (OMIM: 601033) PREDICTED: laminin sub (3700) 823 107.9 1.2e-21 XP_011524284 (OMIM: 226650,226700,245660,600805) P (3243) 771 102.0 6.3e-20 NP_001121189 (OMIM: 226650,226700,245660,600805) l (3277) 771 102.0 6.4e-20 NP_937762 (OMIM: 226650,226700,245660,600805) lami (3333) 771 102.0 6.4e-20 XP_011524282 (OMIM: 226650,226700,245660,600805) P (3336) 771 102.0 6.4e-20 XP_011524281 (OMIM: 226650,226700,245660,600805) P (3339) 771 102.0 6.4e-20 XP_011524280 (OMIM: 226650,226700,245660,600805) P (3342) 771 102.0 6.4e-20 XP_006721658 (OMIM: 601614) PREDICTED: netrin-1 is ( 604) 755 99.3 7.5e-20 NP_004813 (OMIM: 601614) netrin-1 precursor [Homo ( 604) 755 99.3 7.5e-20 NP_009054 (OMIM: 276901,608400,613809) usherin iso (1546) 671 90.4 9.2e-17 XP_011524283 (OMIM: 226650,226700,245660,600805) P (3298) 676 91.4 1e-16 NP_002284 (OMIM: 150290) laminin subunit gamma-1 p (1609) 669 90.2 1.1e-16 NP_996816 (OMIM: 276901,608400,613809) usherin iso (5202) 671 91.1 2e-16 NP_006172 (OMIM: 602349) netrin-3 precursor [Homo ( 580) 638 86.2 6.3e-16 XP_011523959 (OMIM: 150320,615960) PREDICTED: lami (2489) 580 80.5 1.4e-13 XP_011523958 (OMIM: 150320,615960) PREDICTED: lami (2561) 580 80.5 1.5e-13 NP_005550 (OMIM: 150320,615960) laminin subunit al (3075) 580 80.6 1.6e-13 XP_011523957 (OMIM: 150320,615960) PREDICTED: lami (3085) 580 80.6 1.7e-13 NP_001289925 (OMIM: 226650,226700,245660,600805) l ( 488) 550 76.3 5.2e-13 >>XP_005273181 (OMIM: 104530,150310,226650,226700) PREDI (1172 aa) initn: 8180 init1: 8180 opt: 8180 Z-score: 4962.8 bits: 930.2 E(85289): 0 Smith-Waterman score: 8180; 100.0% identity (100.0% similar) in 1172 aa overlap (1-1172:1-1172) 10 20 30 40 50 60 pF1KB4 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB4 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB4 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB4 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB4 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB4 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB4 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB4 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB4 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB4 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB4 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI 1090 1100 1110 1120 1130 1140 1150 1160 1170 pF1KB4 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK :::::::::::::::::::::::::::::::: XP_005 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK 1150 1160 1170 >>NP_000219 (OMIM: 104530,150310,226650,226700) laminin (1172 aa) initn: 8180 init1: 8180 opt: 8180 Z-score: 4962.8 bits: 930.2 E(85289): 0 Smith-Waterman score: 8180; 100.0% identity (100.0% similar) in 1172 aa overlap (1-1172:1-1172) 10 20 30 40 50 60 pF1KB4 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB4 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB4 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB4 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB4 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB4 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB4 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB4 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB4 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB4 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB4 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI 1090 1100 1110 1120 1130 1140 1150 1160 1170 pF1KB4 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK :::::::::::::::::::::::::::::::: NP_000 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK 1150 1160 1170 >>NP_001121113 (OMIM: 104530,150310,226650,226700) lamin (1172 aa) initn: 8180 init1: 8180 opt: 8180 Z-score: 4962.8 bits: 930.2 E(85289): 0 Smith-Waterman score: 8180; 100.0% identity (100.0% similar) in 1172 aa overlap (1-1172:1-1172) 10 20 30 40 50 60 pF1KB4 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB4 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB4 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB4 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB4 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB4 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB4 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB4 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB4 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB4 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB4 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI 1090 1100 1110 1120 1130 1140 1150 1160 1170 pF1KB4 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK :::::::::::::::::::::::::::::::: NP_001 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK 1150 1160 1170 >>NP_001017402 (OMIM: 104530,150310,226650,226700) lamin (1172 aa) initn: 8180 init1: 8180 opt: 8180 Z-score: 4962.8 bits: 930.2 E(85289): 0 Smith-Waterman score: 8180; 100.0% identity (100.0% similar) in 1172 aa overlap (1-1172:1-1172) 10 20 30 40 50 60 pF1KB4 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB4 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB4 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB4 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB4 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB4 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB4 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB4 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB4 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KB4 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KB4 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI 1090 1100 1110 1120 1130 1140 1150 1160 1170 pF1KB4 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK :::::::::::::::::::::::::::::::: NP_001 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK 1150 1160 1170 >>XP_016856761 (OMIM: 104530,150310,226650,226700) PREDI (1108 aa) initn: 6812 init1: 6812 opt: 6812 Z-score: 4136.0 bits: 777.2 E(85289): 0 Smith-Waterman score: 7578; 94.5% identity (94.5% similar) in 1172 aa overlap (1-1172:1-1108) 10 20 30 40 50 60 pF1KB4 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP :::: XP_016 MEFQ-------------------------------------------------------- 190 200 210 220 230 240 pF1KB4 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 --------VQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA 130 140 150 160 170 250 260 270 280 290 300 pF1KB4 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR 180 190 200 210 220 230 310 320 330 340 350 360 pF1KB4 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL 240 250 260 270 280 290 370 380 390 400 410 420 pF1KB4 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL 300 310 320 330 340 350 430 440 450 460 470 480 pF1KB4 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP 360 370 380 390 400 410 490 500 510 520 530 540 pF1KB4 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG 420 430 440 450 460 470 550 560 570 580 590 600 pF1KB4 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG 480 490 500 510 520 530 610 620 630 640 650 660 pF1KB4 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR 540 550 560 570 580 590 670 680 690 700 710 720 pF1KB4 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST 600 610 620 630 640 650 730 740 750 760 770 780 pF1KB4 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL 660 670 680 690 700 710 790 800 810 820 830 840 pF1KB4 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR 720 730 740 750 760 770 850 860 870 880 890 900 pF1KB4 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT 780 790 800 810 820 830 910 920 930 940 950 960 pF1KB4 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR 840 850 860 870 880 890 970 980 990 1000 1010 1020 pF1KB4 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ 900 910 920 930 940 950 1030 1040 1050 1060 1070 1080 pF1KB4 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER 960 970 980 990 1000 1010 1090 1100 1110 1120 1130 1140 pF1KB4 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI 1020 1030 1040 1050 1060 1070 1150 1160 1170 pF1KB4 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK :::::::::::::::::::::::::::::::: XP_016 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK 1080 1090 1100 >>NP_002283 (OMIM: 150325,609049,614199) laminin subunit (1798 aa) initn: 1824 init1: 489 opt: 1258 Z-score: 776.1 bits: 156.2 E(85289): 1.7e-36 Smith-Waterman score: 1669; 45.1% identity (68.7% similar) in 514 aa overlap (21-511:42-552) 10 20 30 40 50 pF1KB4 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLT ::::.::: .:::::::. : :::::::. NP_002 QPLPWELRLGLLLSVLAATLAQAPAPDVPGCSRGSCYPATGDLLVGRADRLTASSTCGLN 20 30 40 50 60 70 60 70 80 90 100 pF1KB4 KPETYC-TQYGEWQMKCCKCDSRQPH----NYYSHRVENVASSSGPMR---WWQSQNDVN :. :: ... . . :: ::::.: : .:::..::..: .:.: ::::.: . NP_002 GPQPYCIVSHLQDEKKCFLCDSRRPFSARDNPHSHRIQNVVTSFAPQRRAAWWQSENGIP 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB4 PVSLQLDLDRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQ :..::::. .:.. ...: :. ::.::.:::.:::.::.::.:.. :: . :: : NP_002 AVTIQLDLEAEFHFTHLIMTFKTFRPAAMLVERSADFGRTWHVYRYFSYDCGADFPGVPL 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB4 GRPQSWQDVRCQSLPQRPNARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFT . :. :.:: :.: .. . .: .: ..: . :: :..::.. .:::::::.: NP_002 APPRHWDDVVCESRYSEIEPSTEG-EVIYRVLDPAIPIPDPYSSRIQNLLKITNLRVNLT 200 210 220 230 240 250 230 240 250 260 270 pF1KB4 RLAPVPQRGYHP-----PSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHD :: . . : . :::. .: ..:.:::.:::..::: ::: : . .:: NP_002 RLHTLGDNLLDPRREIREKYYYALYELVVRGNCFCYGHASECAPAPGAPA--HAEGMVHG 260 270 280 290 300 280 290 300 310 320 330 pF1KB4 VCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQG .:.:.::: : :::.: :: . :::::: .: :..:.:.::...:::: ::. :: . NP_002 ACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSHACRKCECHGHTHSCHFDMAVYLASGN 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB4 AYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCD---- . :::::.:. .: :..:: :. ..:. .: ::.::: :. :. :: NP_002 VSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLRDPAVCRSCDCDPMGSQDGGRCDSHDD 370 380 390 400 410 420 400 410 420 430 440 pF1KB4 P----VTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRR-DMPCDEES : :.::: ::::: : ::. :. :: ::. .. ::.::.:: :. . ::: .: NP_002 PALGLVSGQCRCKEHVVGTRCQQCRDGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPNS 430 440 450 460 470 480 450 460 470 480 490 500 pF1KB4 GRCLCLPNVVGPKCDQCAPYHWKLASGQ-GCEPCACDPHNSLSPQCNQFTGQCPCREGFG : : : :.: ::.: : :: :. ::.:: :: ..:.:::.. :::: ::. . NP_002 GSCYCKRLVTGRGCDRCLPGHWGLSHDLLGCRPCDCDVGGALDPQCDEGTGQCHCRQHMV 490 500 510 520 530 540 510 520 530 540 550 560 pF1KB4 GLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQC : : NP_002 GRRCEQVQPGYFRPFLDHLIWEAEDTRGQVLDVVERLVTPGETPSWTGSGFVRLQEGQTL 550 560 570 580 590 600 >-- initn: 1115 init1: 382 opt: 1563 Z-score: 960.4 bits: 190.3 E(85289): 9.3e-47 Smith-Waterman score: 1563; 32.1% identity (58.4% similar) in 967 aa overlap (250-1172:877-1798) 220 230 240 250 260 270 pF1KB4 NFTRLAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVC : :.::::.: . :: : NP_002 SGQCLCRTGAFGLRCDRCQRGQWGFPSCRPCVCNGHADECNTHTGACLG----------- 850 860 870 880 890 280 290 300 310 320 330 pF1KB4 VCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDC-NGHSETCHFDPAVFAASQGA :. .:.: .:::: ... : : :: :. : : .: . :: . . : NP_002 -CRDHTGGEHCERCIAGFHGDPRLPYGGQ----CRPCPCPEGPGSQRHF---ATSCHQDE 900 910 920 930 940 340 350 360 370 380 390 pF1KB4 YGG--VCDNCRDHTEGKNCERCQLHYFRN-RRPGASIQETCISCEC--DPDGAVPGAPCD :. :: .:: : :: : .: . :::. : ::: . : : : :: NP_002 YSQQIVC-HCRAGYTGLRCEACAPGHFGDPSRPGGR----CQLCECSGNIDPMDPDA-CD 950 960 970 980 990 1000 400 410 420 430 440 pF1KB4 PVTGQCV-CKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSR-RDMP------CD : ::::. : .:..: .: ::::: : : :.:::: ::.::. .. : :: NP_002 PHTGQCLRCLHHTEGPHCAHCKPGFHG--QAARQSCHRCTCNLLGTNPQQCPSPDQCHCD 1010 1020 1030 1040 1050 450 460 470 480 490 500 pF1KB4 EESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREG ::.: ::::: ::.::.::: :.:.::.::.:::: : . .: ::.::::: :: : NP_002 PSSGQCPCLPNVQGPSCDRCAPNFWNLTSGHGCQPCACHPSRARGPTCNEFTGQCHCRAG 1060 1070 1080 1090 1100 1110 510 520 530 540 550 560 pF1KB4 FGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCD ::: :: .: . .:: . :.::::: :: . : : . .:.: ::::..: ::: NP_002 FGGRTCS-----ECQELHWGDPGLQCHACDCDSRGIDTPQCHRFTGHCSCRPGVSGVRCD 1120 1130 1140 1150 1160 1170 570 580 590 600 610 620 pF1KB4 QCQRGYCNRYPVCVACHPCFQTYDADLREQALRFGRLRNATASLWSGPGLEDRGLASRIL :: ::. . .:.: :: :: .: ... : : ::.. . : . : .. : . NP_002 QCARGFSGIFPACHPCHACFGDWDRVVQDLAARTQRLEQRAQELQQTGVL--GAFESSFW 1180 1190 1200 1210 1220 1230 630 640 650 660 670 pF1KB4 DAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRRT-------LQGLQLDLP-LEEETLS . :. ....... .. .::.. : ::: : :. :: ...:... NP_002 HMQEKLGIVQGIVGARNTSAASTAQLVEATEELRREIGEATEHLTQLEADLTDVQDENFN 1240 1250 1260 1270 1280 1290 680 690 700 710 720 730 pF1KB4 LPRDLESLDRSFNGL-LTMYQRKREQFEKISSADPSGAFRMLSTAYEQSAQAAQQVSDSS . : .:.:. .: ::. : .... .. .. ::. . :. :::.: .... :. NP_002 ANHALSGLERDRLALNLTLRQLD-QHLDLLKHSNFLGAYDSIRHAHSQSAEAERRANTSA 1300 1310 1320 1330 1340 1350 740 750 760 770 780 pF1KB4 RLLDQ-LRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDLTPTF-----NKL-CG . . . .: .: . . : .: . ...: : :. :.: :: NP_002 LAVPSPVSNSASARHRTEALMDAQKEDFNSKHMANQRALGKLSAHTHTLSLTDINELVCG 1360 1370 1380 1390 1400 1410 790 800 810 820 830 840 pF1KB4 NSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLRGFNAQLQRT . :. : : : ...: :: :. .:: : . . : .:.:::. NP_002 APGDAPCATSPCGGAGCRDEDGQP---RCGGL--SCNGAAATADLALGRARHTQAELQRA 1420 1430 1440 1450 1460 850 860 870 880 890 900 pF1KB4 RQ-----MIRAAE--ESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLTDP . :.:: ..::. :. :: ...:::.:.:. .. . :::.:.:::.. NP_002 LAEGGSILSRVAETRRQASEAQQRAQAALDKANASRGQVEQANQELQELIQSVKDFLNQE 1470 1480 1490 1500 1510 1520 910 920 930 940 950 pF1KB4 DTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAAR---LPNVDLVLSQTKQDIARA .: .:. :. :: : .:. :: .:.. ::: : : .:: .:..: :. :: NP_002 GADPDSIEMVATRVLELSIPA-SAEQIQHLA--GAIAERVRSLADVDAILARTVGDVRRA 1530 1540 1550 1560 1570 1580 960 970 980 990 1000 1010 pF1KB4 RRLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQ ..: .:..::: :. . ..: : . :... : :: ...:. . : .. . .:: NP_002 EQLLQDARRARSWAEDEKQKAETVQAALEEAQRAQGIAQGAIRGAVADTRDTEQTLYQVQ 1590 1600 1610 1620 1630 1640 1020 1030 1040 1050 1060 1070 pF1KB4 QVLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFE . . ::. ..: .. .. . .: :. . .. : :.. : .:. .: :.. .. NP_002 ERMAGAERALSSAGERARQLDALLEALKLKRAGNSLAASTAEETAGSAQGRAQEAEQLLR 1650 1660 1670 1680 1690 1700 1080 1090 1100 1110 1120 1130 pF1KB4 R-IKQKYAELK---DRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLR . ..: .: .: .:. .:. : :: .... ::..:. ... ..:....: . NP_002 GPLGDQYQTVKALAERKAQG-VLAAQ-ARAEQLRDEARDLLQAAQDKLQRLQELEGTYEE 1710 1720 1730 1740 1750 1760 1140 1150 1160 1170 pF1KB4 GSQAIMLRSADLTGLEKRVEQIRDHINGRVLYYATCK . .:. ..:.: ::: :.... . :: .: : ::. NP_002 NERALESKAAQLDGLEARMRSVLQAINLQVQIYNTCQ 1770 1780 1790 >-- initn: 357 init1: 207 opt: 364 Z-score: 235.6 bits: 56.2 E(85289): 2.2e-06 Smith-Waterman score: 364; 40.1% identity (61.3% similar) in 137 aa overlap (444-578:749-874) 420 430 440 450 460 470 pF1KB4 KPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLA : ::. .:. ..:. . ::: .:. NP_002 VLLPRVLVLEMFSGGDAAALERQATFERYQCHEEG----LVPSKTSPS-EACAPLLISLS 720 730 740 750 760 770 480 490 500 510 520 530 pF1KB4 S--GQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGC . .: :: :.:..::: .:: ::: :. : : :. : :: ::: NP_002 TLIYNGALPCQCNPQGSLSSECNPHGGQCLCKPGVVGRRCDL-----CAPGYYGFGPTGC 780 790 800 810 820 540 550 560 570 580 590 pF1KB4 RACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDAD .::.:. .:. . :.:.::.:::: : : :::.:::: . .: : NP_002 QACQCSHEGALSSLCEKTSGQCLCRTGAFGLRCDRCQRGQWG-FPSCRPCVCNGHADECN 830 840 850 860 870 880 600 610 620 630 640 650 pF1KB4 LREQALRFGRLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQV NP_002 THTGACLGCRDHTGGEHCERCIAGFHGDPRLPYGGQCRPCPCPEGPGSQRHFATSCHQDE 890 900 910 920 930 940 >>XP_005265184 (OMIM: 150325,609049,614199) PREDICTED: l (1798 aa) initn: 1824 init1: 489 opt: 1258 Z-score: 776.1 bits: 156.2 E(85289): 1.7e-36 Smith-Waterman score: 1669; 45.1% identity (68.7% similar) in 514 aa overlap (21-511:42-552) 10 20 30 40 50 pF1KB4 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLT ::::.::: .:::::::. : :::::::. XP_005 QPLPWELRLGLLLSVLAATLAQAPAPDVPGCSRGSCYPATGDLLVGRADRLTASSTCGLN 20 30 40 50 60 70 60 70 80 90 100 pF1KB4 KPETYC-TQYGEWQMKCCKCDSRQPH----NYYSHRVENVASSSGPMR---WWQSQNDVN :. :: ... . . :: ::::.: : .:::..::..: .:.: ::::.: . XP_005 GPQPYCIVSHLQDEKKCFLCDSRRPFSARDNPHSHRIQNVVTSFAPQRRAAWWQSENGIP 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB4 PVSLQLDLDRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQ :..::::. .:.. ...: :. ::.::.:::.:::.::.::.:.. :: . :: : XP_005 AVTIQLDLEAEFHFTHLIMTFKTFRPAAMLVERSADFGRTWHVYRYFSYDCGADFPGVPL 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB4 GRPQSWQDVRCQSLPQRPNARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFT . :. :.:: :.: .. . .: .: ..: . :: :..::.. .:::::::.: XP_005 APPRHWDDVVCESRYSEIEPSTEG-EVIYRVLDPAIPIPDPYSSRIQNLLKITNLRVNLT 200 210 220 230 240 250 230 240 250 260 270 pF1KB4 RLAPVPQRGYHP-----PSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHD :: . . : . :::. .: ..:.:::.:::..::: ::: : . .:: XP_005 RLHTLGDNLLDPRREIREKYYYALYELVVRGNCFCYGHASECAPAPGAPA--HAEGMVHG 260 270 280 290 300 280 290 300 310 320 330 pF1KB4 VCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQG .:.:.::: : :::.: :: . :::::: .: :..:.:.::...:::: ::. :: . XP_005 ACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSHACRKCECHGHTHSCHFDMAVYLASGN 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB4 AYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCD---- . :::::.:. .: :..:: :. ..:. .: ::.::: :. :. :: XP_005 VSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLRDPAVCRSCDCDPMGSQDGGRCDSHDD 370 380 390 400 410 420 400 410 420 430 440 pF1KB4 P----VTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRR-DMPCDEES : :.::: ::::: : ::. :. :: ::. .. ::.::.:: :. . ::: .: XP_005 PALGLVSGQCRCKEHVVGTRCQQCRDGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPNS 430 440 450 460 470 480 450 460 470 480 490 500 pF1KB4 GRCLCLPNVVGPKCDQCAPYHWKLASGQ-GCEPCACDPHNSLSPQCNQFTGQCPCREGFG : : : :.: ::.: : :: :. ::.:: :: ..:.:::.. :::: ::. . XP_005 GSCYCKRLVTGRGCDRCLPGHWGLSHDLLGCRPCDCDVGGALDPQCDEGTGQCHCRQHMV 490 500 510 520 530 540 510 520 530 540 550 560 pF1KB4 GLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQC : : XP_005 GRRCEQVQPGYFRPFLDHLIWEAEDTRGQVLDVVERLVTPGETPSWTGSGFVRLQEGQTL 550 560 570 580 590 600 >-- initn: 1115 init1: 382 opt: 1563 Z-score: 960.4 bits: 190.3 E(85289): 9.3e-47 Smith-Waterman score: 1563; 32.1% identity (58.4% similar) in 967 aa overlap (250-1172:877-1798) 220 230 240 250 260 270 pF1KB4 NFTRLAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVC : :.::::.: . :: : XP_005 SGQCLCRTGAFGLRCDRCQRGQWGFPSCRPCVCNGHADECNTHTGACLG----------- 850 860 870 880 890 280 290 300 310 320 330 pF1KB4 VCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDC-NGHSETCHFDPAVFAASQGA :. .:.: .:::: ... : : :: :. : : .: . :: . . : XP_005 -CRDHTGGEHCERCIAGFHGDPRLPYGGQ----CRPCPCPEGPGSQRHF---ATSCHQDE 900 910 920 930 940 340 350 360 370 380 390 pF1KB4 YGG--VCDNCRDHTEGKNCERCQLHYFRN-RRPGASIQETCISCEC--DPDGAVPGAPCD :. :: .:: : :: : .: . :::. : ::: . : : : :: XP_005 YSQQIVC-HCRAGYTGLRCEACAPGHFGDPSRPGGR----CQLCECSGNIDPMDPDA-CD 950 960 970 980 990 1000 400 410 420 430 440 pF1KB4 PVTGQCV-CKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSR-RDMP------CD : ::::. : .:..: .: ::::: : : :.:::: ::.::. .. : :: XP_005 PHTGQCLRCLHHTEGPHCAHCKPGFHG--QAARQSCHRCTCNLLGTNPQQCPSPDQCHCD 1010 1020 1030 1040 1050 450 460 470 480 490 500 pF1KB4 EESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREG ::.: ::::: ::.::.::: :.:.::.::.:::: : . .: ::.::::: :: : XP_005 PSSGQCPCLPNVQGPSCDRCAPNFWNLTSGHGCQPCACHPSRARGPTCNEFTGQCHCRAG 1060 1070 1080 1090 1100 1110 510 520 530 540 550 560 pF1KB4 FGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCD ::: :: .: . .:: . :.::::: :: . : : . .:.: ::::..: ::: XP_005 FGGRTCS-----ECQELHWGDPGLQCHACDCDSRGIDTPQCHRFTGHCSCRPGVSGVRCD 1120 1130 1140 1150 1160 1170 570 580 590 600 610 620 pF1KB4 QCQRGYCNRYPVCVACHPCFQTYDADLREQALRFGRLRNATASLWSGPGLEDRGLASRIL :: ::. . .:.: :: :: .: ... : : ::.. . : . : .. : . XP_005 QCARGFSGIFPACHPCHACFGDWDRVVQDLAARTQRLEQRAQELQQTGVL--GAFESSFW 1180 1190 1200 1210 1220 1230 630 640 650 660 670 pF1KB4 DAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRRT-------LQGLQLDLP-LEEETLS . :. ....... .. .::.. : ::: : :. :: ...:... XP_005 HMQEKLGIVQGIVGARNTSAASTAQLVEATEELRREIGEATEHLTQLEADLTDVQDENFN 1240 1250 1260 1270 1280 1290 680 690 700 710 720 730 pF1KB4 LPRDLESLDRSFNGL-LTMYQRKREQFEKISSADPSGAFRMLSTAYEQSAQAAQQVSDSS . : .:.:. .: ::. : .... .. .. ::. . :. :::.: .... :. XP_005 ANHALSGLERDRLALNLTLRQLD-QHLDLLKHSNFLGAYDSIRHAHSQSAEAERRANTSA 1300 1310 1320 1330 1340 1350 740 750 760 770 780 pF1KB4 RLLDQ-LRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDLTPTF-----NKL-CG . . . .: .: . . : .: . ...: : :. :.: :: XP_005 LAVPSPVSNSASARHRTEALMDAQKEDFNSKHMANQRALGKLSAHTHTLSLTDINELVCG 1360 1370 1380 1390 1400 1410 790 800 810 820 830 840 pF1KB4 NSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLRGFNAQLQRT . :. : : : ...: :: :. .:: : . . : .:.:::. XP_005 APGDAPCATSPCGGAGCRDEDGQP---RCGGL--SCNGAAATADLALGRARHTQAELQRA 1420 1430 1440 1450 1460 850 860 870 880 890 900 pF1KB4 RQ-----MIRAAE--ESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLTDP . :.:: ..::. :. :: ...:::.:.:. .. . :::.:.:::.. XP_005 LAEGGSILSRVAETRRQASEAQQRAQAALDKANASRGQVEQANQELQELIQSVKDFLNQE 1470 1480 1490 1500 1510 1520 910 920 930 940 950 pF1KB4 DTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAAR---LPNVDLVLSQTKQDIARA .: .:. :. :: : .:. :: .:.. ::: : : .:: .:..: :. :: XP_005 GADPDSIEMVATRVLELSIPA-SAEQIQHLA--GAIAERVRSLADVDAILARTVGDVRRA 1530 1540 1550 1560 1570 1580 960 970 980 990 1000 1010 pF1KB4 RRLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQ ..: .:..::: :. . ..: : . :... : :: ...:. . : .. . .:: XP_005 EQLLQDARRARSWAEDEKQKAETVQAALEEAQRAQGIAQGAIRGAVADTRDTEQTLYQVQ 1590 1600 1610 1620 1630 1640 1020 1030 1040 1050 1060 1070 pF1KB4 QVLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFE . . ::. ..: .. .. . .: :. . .. : :.. : .:. .: :.. .. XP_005 ERMAGAERALSSAGERARQLDALLEALKLKRAGNSLAASTAEETAGSAQGRAQEAEQLLR 1650 1660 1670 1680 1690 1700 1080 1090 1100 1110 1120 1130 pF1KB4 R-IKQKYAELK---DRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLR . ..: .: .: .:. .:. : :: .... ::..:. ... ..:....: . XP_005 GPLGDQYQTVKALAERKAQG-VLAAQ-ARAEQLRDEARDLLQAAQDKLQRLQELEGTYEE 1710 1720 1730 1740 1750 1760 1140 1150 1160 1170 pF1KB4 GSQAIMLRSADLTGLEKRVEQIRDHINGRVLYYATCK . .:. ..:.: ::: :.... . :: .: : ::. XP_005 NERALESKAAQLDGLEARMRSVLQAINLQVQIYNTCQ 1770 1780 1790 >-- initn: 357 init1: 207 opt: 364 Z-score: 235.6 bits: 56.2 E(85289): 2.2e-06 Smith-Waterman score: 364; 40.1% identity (61.3% similar) in 137 aa overlap (444-578:749-874) 420 430 440 450 460 470 pF1KB4 KPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLA : ::. .:. ..:. . ::: .:. XP_005 VLLPRVLVLEMFSGGDAAALERQATFERYQCHEEG----LVPSKTSPS-EACAPLLISLS 720 730 740 750 760 770 480 490 500 510 520 530 pF1KB4 S--GQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGC . .: :: :.:..::: .:: ::: :. : : :. : :: ::: XP_005 TLIYNGALPCQCNPQGSLSSECNPHGGQCLCKPGVVGRRCDL-----CAPGYYGFGPTGC 780 790 800 810 820 540 550 560 570 580 590 pF1KB4 RACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDAD .::.:. .:. . :.:.::.:::: : : :::.:::: . .: : XP_005 QACQCSHEGALSSLCEKTSGQCLCRTGAFGLRCDRCQRGQWG-FPSCRPCVCNGHADECN 830 840 850 860 870 880 600 610 620 630 640 650 pF1KB4 LREQALRFGRLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQV XP_005 THTGACLGCRDHTGGEHCERCIAGFHGDPRLPYGGQCRPCPCPEGPGSQRHFATSCHQDE 890 900 910 920 930 940 >>NP_001304977 (OMIM: 616380) laminin subunit beta-4 iso (772 aa) initn: 1568 init1: 505 opt: 1251 Z-score: 776.0 bits: 155.0 E(85289): 1.7e-36 Smith-Waterman score: 1609; 43.2% identity (67.6% similar) in 525 aa overlap (17-515:19-540) 10 20 30 40 50 pF1KB4 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCT- ::. :.::::.: .:::::::. : :::::::.. . :: NP_001 MQFQLTLFLHLGWLSYSKAQDDCNRGACHPTTGDLLVGRNTQLMASSTCGLSRAQKYCIL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 QYGEWQMKCCKCDSRQPHNYY----SHRVENVASSSGPMR---WWQSQNDVNPVSLQLDL .: : ..:: :::: :.. : :: .::: : : : ::::.: .. ::..::: NP_001 SYLEGEQKCFICDSRFPYDPYDQPNSHTIENVIVSFEPDREKKWWQSENGLDHVSIRLDL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 DRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQD . :....... :. ::.::.:::.:.:..:.:..:.: ::...:: . .:. :. : NP_001 EALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFPNITSGQAQGVGD 130 140 150 160 170 180 180 190 200 210 220 pF1KB4 VRCQSLPQ--RPNARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVP . :.: . .:.. ::.: :...: : : ::.. .::::.:::.: . NP_001 IVCDSKYSDIEPST---GGEVVLKVLDPSFEIENPYSPYIQDLVTLTNLRINFTKLHTLG 190 200 210 220 230 230 240 250 260 270 280 pF1KB4 QR--GYHPPSA----YYAVSQLRLQGSCFCHGHADRCAPKPGASAGP-STAVQVHDVCVC . : . .. :::. .. ..:::::.:::..: : . : .:: ::: NP_001 DALLGRRQNDSLDKYYYALYEMIVRGSCFCNGHASECRPMQKMRGDVFSPPGMVHGQCVC 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB4 QHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGG :::: ::::::: :... ::::: . . :. :.::.:: :::: ... :: : :: NP_001 QHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSCSCNSHSSRCHFDMTTYLASGGLSGG 300 310 320 330 340 350 350 360 370 380 390 pF1KB4 VCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPC----DP--- ::..:. .:::..:.::. ..:. : .:: :::::::.. :. : :: NP_001 VCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPDGTISGGICVSHSDPALG 360 370 380 390 400 410 400 410 420 430 440 450 pF1KB4 -VTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLC :.:::.:::.:.: .:: :::. ::. ..: ::. :::: ::: . :: ..:.::: NP_001 SVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLC 420 430 440 450 460 470 460 470 480 490 500 510 pF1KB4 LPNVVGPKCDQCAPYHWKLASG-QGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCS : :.: .:..:. .: :.. .:: :: :: .. : :. .::: :: : :: NP_001 LSYVTGAHCEECTVGYWGLGNHLHGCSPCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCS 480 490 500 510 520 530 520 530 540 550 560 570 pF1KB4 AAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYC : NP_001 EPAPGYFFAPLNFYLYEAEEATTLQGLAPLGSETFGQSPAVHVVLGEPVPGNPVTWTGPG 540 550 560 570 580 590 >>NP_001304976 (OMIM: 616380) laminin subunit beta-4 iso (1101 aa) initn: 1474 init1: 505 opt: 1251 Z-score: 774.3 bits: 155.1 E(85289): 2.2e-36 Smith-Waterman score: 1609; 43.2% identity (67.6% similar) in 525 aa overlap (17-515:19-540) 10 20 30 40 50 pF1KB4 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCT- ::. :.::::.: .:::::::. : :::::::.. . :: NP_001 MQFQLTLFLHLGWLSYSKAQDDCNRGACHPTTGDLLVGRNTQLMASSTCGLSRAQKYCIL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 QYGEWQMKCCKCDSRQPHNYY----SHRVENVASSSGPMR---WWQSQNDVNPVSLQLDL .: : ..:: :::: :.. : :: .::: : : : ::::.: .. ::..::: NP_001 SYLEGEQKCFICDSRFPYDPYDQPNSHTIENVIVSFEPDREKKWWQSENGLDHVSIRLDL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 DRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQD . :....... :. ::.::.:::.:.:..:.:..:.: ::...:: . .:. :. : NP_001 EALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFPNITSGQAQGVGD 130 140 150 160 170 180 180 190 200 210 220 pF1KB4 VRCQSLPQ--RPNARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVP . :.: . .:.. ::.: :...: : : ::.. .::::.:::.: . NP_001 IVCDSKYSDIEPST---GGEVVLKVLDPSFEIENPYSPYIQDLVTLTNLRINFTKLHTLG 190 200 210 220 230 230 240 250 260 270 280 pF1KB4 QR--GYHPPSA----YYAVSQLRLQGSCFCHGHADRCAPKPGASAGP-STAVQVHDVCVC . : . .. :::. .. ..:::::.:::..: : . : .:: ::: NP_001 DALLGRRQNDSLDKYYYALYEMIVRGSCFCNGHASECRPMQKMRGDVFSPPGMVHGQCVC 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB4 QHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGG :::: ::::::: :... ::::: . . :. :.::.:: :::: ... :: : :: NP_001 QHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSCSCNSHSSRCHFDMTTYLASGGLSGG 300 310 320 330 340 350 350 360 370 380 390 pF1KB4 VCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPC----DP--- ::..:. .:::..:.::. ..:. : .:: :::::::.. :. : :: NP_001 VCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPDGTISGGICVSHSDPALG 360 370 380 390 400 410 400 410 420 430 440 450 pF1KB4 -VTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLC :.:::.:::.:.: .:: :::. ::. ..: ::. :::: ::: . :: ..:.::: NP_001 SVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLC 420 430 440 450 460 470 460 470 480 490 500 510 pF1KB4 LPNVVGPKCDQCAPYHWKLASG-QGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCS : :.: .:..:. .: :.. .:: :: :: .. : :. .::: :: : :: NP_001 LSYVTGAHCEECTVGYWGLGNHLHGCSPCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCS 480 490 500 510 520 530 520 530 540 550 560 570 pF1KB4 AAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYC : NP_001 EPAPGYFFAPLNFYLYEAEEATTLQGLAPLGSETFGQSPAVHVVLGEPVPGNPVTWTGPG 540 550 560 570 580 590 >-- initn: 484 init1: 237 opt: 527 Z-score: 336.6 bits: 74.2 E(85289): 5.2e-12 Smith-Waterman score: 527; 33.6% identity (55.0% similar) in 289 aa overlap (233-495:820-1094) 210 220 230 240 250 pF1KB4 TQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHA-----D :: .. .: . .. :.: :::.. : NP_001 CKPLVVGRCCDRCSTGSYDLGHHGCHPCHCHPQGSKDTVCD-QVTGQCPCHGEVSGRRCD 790 800 810 820 830 840 260 270 280 290 300 pF1KB4 RC-APKPG-ASAGPSTAVQVHDVC--------VCQHNTAGPNCERCAP-FYNNRPWRPAE :: : : : : . ..: : :.: ::::: .:.: :. NP_001 RCLAGYFGFPSCHPCPCNRFAELCDPETGSCFNCGGFTTGRNCERCIDGYYGN----PSS 850 860 870 880 890 900 310 320 330 340 350 360 pF1KB4 GQDAHECQRCDC-NGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRN :: :. : : . : . .: . . .. .: :: . : .: .:. .. : NP_001 GQP---CRPCLCPDDPSSNQYFAHSCYQNLWSS-DVIC-NCLQGYTGTQCGECSTGFYGN 910 920 930 940 950 370 380 390 400 410 420 pF1KB4 RRPGASIQETCISCECDPDGAVPGAPCDPVTGQCV-CKEHVQGERCDLCKPGFTGLTYAN : ... . : .:. . : . : :. :::.:. : ...:: :.::::: : : NP_001 PRISGAPCQPC-ACNNNIDVTDP-ESCSRVTGECLRCLHNTQGANCQLCKPGHYG--SAL 960 970 980 990 1000 1010 430 440 450 460 470 pF1KB4 PQGCHRCDCNILG-SRRDMP-------CDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQ : :.::.:. : : . : :: .: : :::::.: ::.:: .:.:. :. NP_001 NQTCRRCSCHASGVSPMECPPGGGACLCDPVTGACPCLPNVTGLACDRCADGYWNLVPGR 1020 1030 1040 1050 1060 1070 480 490 500 510 520 530 pF1KB4 GCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDC ::. : :::..: : .:.: NP_001 GCQSCDCDPRTSQSSHCDQARYFKAY 1080 1090 1100 >>XP_011514282 (OMIM: 616380) PREDICTED: laminin subunit (1564 aa) initn: 1665 init1: 505 opt: 1251 Z-score: 772.5 bits: 155.3 E(85289): 2.7e-36 Smith-Waterman score: 1609; 43.2% identity (67.6% similar) in 525 aa overlap (17-515:19-540) 10 20 30 40 50 pF1KB4 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCT- ::. :.::::.: .:::::::. : :::::::.. . :: XP_011 MQFQLTLFLHLGWLSYSKAQDDCNRGACHPTTGDLLVGRNTQLMASSTCGLSRAQKYCIL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 QYGEWQMKCCKCDSRQPHNYY----SHRVENVASSSGPMR---WWQSQNDVNPVSLQLDL .: : ..:: :::: :.. : :: .::: : : : ::::.: .. ::..::: XP_011 SYLEGEQKCFICDSRFPYDPYDQPNSHTIENVIVSFEPDREKKWWQSENGLDHVSIRLDL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 DRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQD . :....... :. ::.::.:::.:.:..:.:..:.: ::...:: . .:. :. : XP_011 EALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFPNITSGQAQGVGD 130 140 150 160 170 180 180 190 200 210 220 pF1KB4 VRCQSLPQ--RPNARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVP . :.: . .:.. ::.: :...: : : ::.. .::::.:::.: . XP_011 IVCDSKYSDIEPST---GGEVVLKVLDPSFEIENPYSPYIQDLVTLTNLRINFTKLHTLG 190 200 210 220 230 230 240 250 260 270 280 pF1KB4 QR--GYHPPSA----YYAVSQLRLQGSCFCHGHADRCAPKPGASAGP-STAVQVHDVCVC . : . .. :::. .. ..:::::.:::..: : . : .:: ::: XP_011 DALLGRRQNDSLDKYYYALYEMIVRGSCFCNGHASECRPMQKMRGDVFSPPGMVHGQCVC 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB4 QHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGG :::: ::::::: :... ::::: . . :. :.::.:: :::: ... :: : :: XP_011 QHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSCSCNSHSSRCHFDMTTYLASGGLSGG 300 310 320 330 340 350 350 360 370 380 390 pF1KB4 VCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPC----DP--- ::..:. .:::..:.::. ..:. : .:: :::::::.. :. : :: XP_011 VCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPDGTISGGICVSHSDPALG 360 370 380 390 400 410 400 410 420 430 440 450 pF1KB4 -VTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLC :.:::.:::.:.: .:: :::. ::. ..: ::. :::: ::: . :: ..:.::: XP_011 SVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLC 420 430 440 450 460 470 460 470 480 490 500 510 pF1KB4 LPNVVGPKCDQCAPYHWKLASG-QGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCS : :.: .:..:. .: :.. .:: :: :: .. : :. .::: :: : :: XP_011 LSYVTGAHCEECTVGYWGLGNHLHGCSPCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCS 480 490 500 510 520 530 520 530 540 550 560 570 pF1KB4 AAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYC : XP_011 EPAPGYFFAPLNFYLYEAEEATTLQGLAPLGSETFGQSPAVHVVLGEPVPGNPVTWTGPG 540 550 560 570 580 590 >-- initn: 737 init1: 335 opt: 1180 Z-score: 729.6 bits: 147.4 E(85289): 6.7e-34 Smith-Waterman score: 1180; 28.2% identity (56.6% similar) in 776 aa overlap (233-971:820-1561) 210 220 230 240 250 pF1KB4 TQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHA-----D :: .. .: . .. :.: :::.. : XP_011 CKPLVVGRCCDRCSTGSYDLGHHGCHPCHCHPQGSKDTVCD-QVTGQCPCHGEVSGRRCD 790 800 810 820 830 840 260 270 280 290 300 pF1KB4 RC-APKPG-ASAGPSTAVQVHDVC--------VCQHNTAGPNCERCAP-FYNNRPWRPAE :: : : : : . ..: : :.: ::::: .:.: :. XP_011 RCLAGYFGFPSCHPCPCNRFAELCDPETGSCFNCGGFTTGRNCERCIDGYYGN----PSS 850 860 870 880 890 900 310 320 330 340 350 360 pF1KB4 GQDAHECQRCDCNGHSETCHFDPAVFAAS--QGAYGG--VCDNCRDHTEGKNCERCQLHY :: :. : : . .. :: : :. ... .: :: . : .: .:. . XP_011 GQP---CRPCLCPDDPSSNQY----FAHSCYQNLWSSDVIC-NCLQGYTGTQCGECSTGF 910 920 930 940 950 370 380 390 400 410 420 pF1KB4 FRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCV-CKEHVQGERCDLCKPGFTGLT . : : ... . : .:. . : . : . :. :::.:. : ...:: :.::::: : XP_011 YGNPRISGAPCQPC-ACNNNIDVTDPES-CSRVTGECLRCLHNTQGANCQLCKPGHYG-- 960 970 980 990 1000 1010 430 440 450 460 470 pF1KB4 YANPQGCHRCDCNILG-SRRDMP-------CDEESGRCLCLPNVVGPKCDQCAPYHWKLA : : :.::.:. : : . : :: .: : :::::.: ::.:: .:.:. XP_011 SALNQTCRRCSCHASGVSPMECPPGGGACLCDPVTGACPCLPNVTGLACDRCADGYWNLV 1020 1030 1040 1050 1060 1070 480 490 500 510 520 530 pF1KB4 SGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRA :.::. : :::..: : .:.:.::::::. :.:: :: .: . ::: : XP_011 PGRGCQSCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCS-----ECQENYYGDPPGRCIP 1080 1090 1100 1110 1120 540 550 560 570 580 590 pF1KB4 CDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLR :::. ::. : :: .: : :: :..: :::.: ::. ...:.:. :: ::. .: . XP_011 CDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGHSQEFPTCLQCHLCFDQWDHTI- 1130 1140 1150 1160 1170 1180 600 610 620 630 640 pF1KB4 EQALRFGRLRNATASLWS-GPGLEDRGLASRILDA-----KSKIEQIRAVLSSPAVTEQE . : .:. .: . ..::. . . .: .... .:. .:. :. . XP_011 ------SSLSKAVQGLMRLAANMEDKRETLPVCEADFKDLRGNVSEIERILKHPVFPSGK 1190 1200 1210 1220 1230 1240 650 660 670 680 690 700 pF1KB4 VAQVASAILSLRRTLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKIS .: . :.:: .. :. .: : .: .: . :: :.. . .. XP_011 FLKVKDYHDSVRRQIMQLNEQLKAVYEFQDLKDTIERAKNEADLLLEDLQEEIDLQSSVL 1250 1260 1270 1280 1290 1300 710 720 730 740 750 760 pF1KB4 SADPSGAFRMLSTAYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKL .:. . . . .. :. :..: ......: .. ..: . .. . :. : XP_011 NASIADSSENIKKYYHISSSAEKKINETSSTINTSANTRNDLLTILDTLTSKGN-----L 1310 1320 1330 1340 1350 770 780 790 800 810 820 pF1KB4 VALRLEMSSLPDLTPTFNKLCGNSRQMACTPISCPGELCPQDNG-TAC-GSRCRGVLPRA ::.. ..::. .:.::. .. :.:. : : :: .: : : :.: : . XP_011 SLERLKQIKIPDIQILNEKVCGDPGNVPCVPLPCGGALCTGRKGHRKCRGPGCHGSLTLS 1360 1370 1380 1390 1400 1410 830 840 850 860 870 880 pF1KB4 GGAFLMAGQVAEQLRGFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDV .:. : .. .:... :.. ...:.. :.: ...: .:. ... :.: . . XP_011 TNALQKAQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNALQLREKLGNIRNQSDSEE 1420 1430 1440 1450 1460 1470 890 900 910 920 930 940 pF1KB4 RRTRLLIQQVRDFLTDPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNV . :.:..:..:: . .. :..:...:: . :: : .. ... .:: . XP_011 ENINLFIKKVKNFLLEENVPPEDIEKVANGVLDIHLPIPSQNLTDELVKIQKHMQLCEDY 1480 1490 1500 1510 1520 1530 950 960 970 980 990 1000 pF1KB4 DLVLSQTKQDIARARRLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTS .. ... :..: ..:. :.. XP_011 RTDENRLNEEADGAQKLLVKAKAAENLLS 1540 1550 1560 1172 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 21:45:14 2016 done: Thu Nov 3 21:45:17 2016 Total Scan time: 16.350 Total Display time: 0.570 Function used was FASTA [36.3.4 Apr, 2011]