Result of FASTA (omim) for pF1KB4802
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB4802, 1172 aa
  1>>>pF1KB4802 1172 - 1172 aa - 1172 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.2192+/-0.000521; mu= 9.7722+/- 0.032
 mean_var=273.6278+/-54.184, 0's: 0 Z-trim(116.6): 292  B-trim: 104 in 2/53
 Lambda= 0.077534
 statistics sampled from 27641 (27959) to 27641 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.666), E-opt: 0.2 (0.328), width:  16
 Scan time: 16.350

The best scores are:                                      opt bits E(85289)
XP_005273181 (OMIM: 104530,150310,226650,226700) P (1172) 8180 930.2       0
NP_000219 (OMIM: 104530,150310,226650,226700) lami (1172) 8180 930.2       0
NP_001121113 (OMIM: 104530,150310,226650,226700) l (1172) 8180 930.2       0
NP_001017402 (OMIM: 104530,150310,226650,226700) l (1172) 8180 930.2       0
XP_016856761 (OMIM: 104530,150310,226650,226700) P (1108) 6812 777.2       0
NP_002283 (OMIM: 150325,609049,614199) laminin sub (1798) 1258 156.2 1.7e-36
XP_005265184 (OMIM: 150325,609049,614199) PREDICTE (1798) 1258 156.2 1.7e-36
NP_001304977 (OMIM: 616380) laminin subunit beta-4 ( 772) 1251 155.0 1.7e-36
NP_001304976 (OMIM: 616380) laminin subunit beta-4 (1101) 1251 155.1 2.2e-36
XP_011514282 (OMIM: 616380) PREDICTED: laminin sub (1564) 1251 155.3 2.7e-36
XP_016867369 (OMIM: 616380) PREDICTED: laminin sub (1567) 1251 155.3 2.7e-36
XP_011514281 (OMIM: 616380) PREDICTED: laminin sub (1703) 1251 155.4 2.9e-36
XP_011514280 (OMIM: 616380) PREDICTED: laminin sub (1723) 1251 155.4 2.9e-36
XP_016867368 (OMIM: 616380) PREDICTED: laminin sub (1753) 1251 155.4 2.9e-36
NP_001304975 (OMIM: 616380) laminin subunit beta-4 (1761) 1251 155.4 2.9e-36
NP_031382 (OMIM: 616380) laminin subunit beta-4 is (1761) 1251 155.4 2.9e-36
XP_011514277 (OMIM: 616380) PREDICTED: laminin sub (1772) 1251 155.4   3e-36
XP_016867691 (OMIM: 150240,615191) PREDICTED: lami (1212) 1119 140.4 6.5e-32
NP_002282 (OMIM: 150240,615191) laminin subunit be (1786) 1119 140.6 8.3e-32
XP_016867690 (OMIM: 150240,615191) PREDICTED: lami (1810) 1119 140.6 8.3e-32
NP_001316629 (OMIM: 610401) netrin-4 isoform 2 pre ( 605) 1007 127.5 2.5e-28
NP_067052 (OMIM: 610401) netrin-4 isoform 1 precur ( 628) 1007 127.6 2.5e-28
NP_001316630 (OMIM: 610401) netrin-4 isoform 3 [Ho ( 591)  974 123.8 3.1e-27
NP_001316631 (OMIM: 610401) netrin-4 isoform 3 [Ho ( 591)  974 123.8 3.1e-27
XP_011516423 (OMIM: 604349,614115) PREDICTED: lami (1581)  841 109.5 1.8e-22
NP_006050 (OMIM: 604349,614115) laminin subunit ga (1575)  827 107.9 5.2e-22
XP_006716984 (OMIM: 604349,614115) PREDICTED: lami (1259)  823 107.3 6.1e-22
XP_006723861 (OMIM: 601033) PREDICTED: laminin sub (2300)  823 107.7   9e-22
XP_011527121 (OMIM: 601033) PREDICTED: laminin sub (3609)  823 107.9 1.2e-21
XP_011527120 (OMIM: 601033) PREDICTED: laminin sub (3654)  823 107.9 1.2e-21
NP_005551 (OMIM: 601033) laminin subunit alpha-5 p (3695)  823 107.9 1.2e-21
XP_006723859 (OMIM: 601033) PREDICTED: laminin sub (3700)  823 107.9 1.2e-21
XP_011524284 (OMIM: 226650,226700,245660,600805) P (3243)  771 102.0 6.3e-20
NP_001121189 (OMIM: 226650,226700,245660,600805) l (3277)  771 102.0 6.4e-20
NP_937762 (OMIM: 226650,226700,245660,600805) lami (3333)  771 102.0 6.4e-20
XP_011524282 (OMIM: 226650,226700,245660,600805) P (3336)  771 102.0 6.4e-20
XP_011524281 (OMIM: 226650,226700,245660,600805) P (3339)  771 102.0 6.4e-20
XP_011524280 (OMIM: 226650,226700,245660,600805) P (3342)  771 102.0 6.4e-20
XP_006721658 (OMIM: 601614) PREDICTED: netrin-1 is ( 604)  755 99.3 7.5e-20
NP_004813 (OMIM: 601614) netrin-1 precursor [Homo  ( 604)  755 99.3 7.5e-20
NP_009054 (OMIM: 276901,608400,613809) usherin iso (1546)  671 90.4 9.2e-17
XP_011524283 (OMIM: 226650,226700,245660,600805) P (3298)  676 91.4   1e-16
NP_002284 (OMIM: 150290) laminin subunit gamma-1 p (1609)  669 90.2 1.1e-16
NP_996816 (OMIM: 276901,608400,613809) usherin iso (5202)  671 91.1   2e-16
NP_006172 (OMIM: 602349) netrin-3 precursor [Homo  ( 580)  638 86.2 6.3e-16
XP_011523959 (OMIM: 150320,615960) PREDICTED: lami (2489)  580 80.5 1.4e-13
XP_011523958 (OMIM: 150320,615960) PREDICTED: lami (2561)  580 80.5 1.5e-13
NP_005550 (OMIM: 150320,615960) laminin subunit al (3075)  580 80.6 1.6e-13
XP_011523957 (OMIM: 150320,615960) PREDICTED: lami (3085)  580 80.6 1.7e-13
NP_001289925 (OMIM: 226650,226700,245660,600805) l ( 488)  550 76.3 5.2e-13


>>XP_005273181 (OMIM: 104530,150310,226650,226700) PREDI  (1172 aa)
 initn: 8180 init1: 8180 opt: 8180  Z-score: 4962.8  bits: 930.2 E(85289):    0
Smith-Waterman score: 8180; 100.0% identity (100.0% similar) in 1172 aa overlap (1-1172:1-1172)

               10        20        30        40        50        60
pF1KB4 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB4 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB4 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB4 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB4 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB4 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB4 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB4 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB4 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB4 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI
             1090      1100      1110      1120      1130      1140

             1150      1160      1170  
pF1KB4 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK
       ::::::::::::::::::::::::::::::::
XP_005 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK
             1150      1160      1170  

>>NP_000219 (OMIM: 104530,150310,226650,226700) laminin   (1172 aa)
 initn: 8180 init1: 8180 opt: 8180  Z-score: 4962.8  bits: 930.2 E(85289):    0
Smith-Waterman score: 8180; 100.0% identity (100.0% similar) in 1172 aa overlap (1-1172:1-1172)

               10        20        30        40        50        60
pF1KB4 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB4 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB4 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB4 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB4 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB4 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB4 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB4 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB4 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB4 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI
             1090      1100      1110      1120      1130      1140

             1150      1160      1170  
pF1KB4 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK
       ::::::::::::::::::::::::::::::::
NP_000 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK
             1150      1160      1170  

>>NP_001121113 (OMIM: 104530,150310,226650,226700) lamin  (1172 aa)
 initn: 8180 init1: 8180 opt: 8180  Z-score: 4962.8  bits: 930.2 E(85289):    0
Smith-Waterman score: 8180; 100.0% identity (100.0% similar) in 1172 aa overlap (1-1172:1-1172)

               10        20        30        40        50        60
pF1KB4 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB4 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB4 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB4 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB4 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB4 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB4 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB4 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB4 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB4 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI
             1090      1100      1110      1120      1130      1140

             1150      1160      1170  
pF1KB4 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK
       ::::::::::::::::::::::::::::::::
NP_001 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK
             1150      1160      1170  

>>NP_001017402 (OMIM: 104530,150310,226650,226700) lamin  (1172 aa)
 initn: 8180 init1: 8180 opt: 8180  Z-score: 4962.8  bits: 930.2 E(85289):    0
Smith-Waterman score: 8180; 100.0% identity (100.0% similar) in 1172 aa overlap (1-1172:1-1172)

               10        20        30        40        50        60
pF1KB4 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB4 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB4 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB4 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB4 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB4 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB4 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB4 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB4 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB4 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI
             1090      1100      1110      1120      1130      1140

             1150      1160      1170  
pF1KB4 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK
       ::::::::::::::::::::::::::::::::
NP_001 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK
             1150      1160      1170  

>>XP_016856761 (OMIM: 104530,150310,226650,226700) PREDI  (1108 aa)
 initn: 6812 init1: 6812 opt: 6812  Z-score: 4136.0  bits: 777.2 E(85289):    0
Smith-Waterman score: 7578; 94.5% identity (94.5% similar) in 1172 aa overlap (1-1172:1-1108)

               10        20        30        40        50        60
pF1KB4 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP
       ::::                                                        
XP_016 MEFQ--------------------------------------------------------
                                                                   

              190       200       210       220       230       240
pF1KB4 NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA
               ::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 --------VQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA
                  130       140       150       160       170      

              250       260       270       280       290       300
pF1KB4 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR
        180       190       200       210       220       230      

              310       320       330       340       350       360
pF1KB4 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL
        240       250       260       270       280       290      

              370       380       390       400       410       420
pF1KB4 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL
        300       310       320       330       340       350      

              430       440       450       460       470       480
pF1KB4 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP
        360       370       380       390       400       410      

              490       500       510       520       530       540
pF1KB4 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG
        420       430       440       450       460       470      

              550       560       570       580       590       600
pF1KB4 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG
        480       490       500       510       520       530      

              610       620       630       640       650       660
pF1KB4 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR
        540       550       560       570       580       590      

              670       680       690       700       710       720
pF1KB4 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST
        600       610       620       630       640       650      

              730       740       750       760       770       780
pF1KB4 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL
        660       670       680       690       700       710      

              790       800       810       820       830       840
pF1KB4 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR
        720       730       740       750       760       770      

              850       860       870       880       890       900
pF1KB4 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT
        780       790       800       810       820       830      

              910       920       930       940       950       960
pF1KB4 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR
        840       850       860       870       880       890      

              970       980       990      1000      1010      1020
pF1KB4 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ
        900       910       920       930       940       950      

             1030      1040      1050      1060      1070      1080
pF1KB4 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER
        960       970       980       990      1000      1010      

             1090      1100      1110      1120      1130      1140
pF1KB4 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI
       1020      1030      1040      1050      1060      1070      

             1150      1160      1170  
pF1KB4 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK
       ::::::::::::::::::::::::::::::::
XP_016 MLRSADLTGLEKRVEQIRDHINGRVLYYATCK
       1080      1090      1100        

>>NP_002283 (OMIM: 150325,609049,614199) laminin subunit  (1798 aa)
 initn: 1824 init1: 489 opt: 1258  Z-score: 776.1  bits: 156.2 E(85289): 1.7e-36
Smith-Waterman score: 1669; 45.1% identity (68.7% similar) in 514 aa overlap (21-511:42-552)

                         10        20        30        40        50
pF1KB4           MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLT
                                     ::::.::: .:::::::.  : :::::::.
NP_002 QPLPWELRLGLLLSVLAATLAQAPAPDVPGCSRGSCYPATGDLLVGRADRLTASSTCGLN
              20        30        40        50        60        70 

                60        70            80        90          100  
pF1KB4 KPETYC-TQYGEWQMKCCKCDSRQPH----NYYSHRVENVASSSGPMR---WWQSQNDVN
        :. :: ... . . ::  ::::.:     : .:::..::..: .:.:   ::::.: . 
NP_002 GPQPYCIVSHLQDEKKCFLCDSRRPFSARDNPHSHRIQNVVTSFAPQRRAAWWQSENGIP
              80        90       100       110       120       130 

            110       120       130       140       150       160  
pF1KB4 PVSLQLDLDRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQ
        :..::::. .:.. ...: :.   ::.::.:::.:::.::.::.:.. :: . :: :  
NP_002 AVTIQLDLEAEFHFTHLIMTFKTFRPAAMLVERSADFGRTWHVYRYFSYDCGADFPGVPL
             140       150       160       170       180       190 

            170       180       190       200       210       220  
pF1KB4 GRPQSWQDVRCQSLPQRPNARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFT
       . :. :.:: :.:  .. .   .: .:   ..: .  ::   :..::.. .:::::::.:
NP_002 APPRHWDDVVCESRYSEIEPSTEG-EVIYRVLDPAIPIPDPYSSRIQNLLKITNLRVNLT
             200       210        220       230       240       250

            230            240       250       260       270       
pF1KB4 RLAPVPQRGYHP-----PSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHD
       ::  . .    :      . :::. .: ..:.:::.:::..::: ::: :   .  .:: 
NP_002 RLHTLGDNLLDPRREIREKYYYALYELVVRGNCFCYGHASECAPAPGAPA--HAEGMVHG
              260       270       280       290       300          

       280       290       300       310       320       330       
pF1KB4 VCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQG
       .:.:.::: : :::.:  :: . ::::::   .: :..:.:.::...:::: ::. :: .
NP_002 ACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSHACRKCECHGHTHSCHFDMAVYLASGN
      310       320       330       340       350       360        

       340       350       360       370       380       390       
pF1KB4 AYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCD----
       . :::::.:. .: :..:: :.  ..:.         .: ::.::: :.  :. ::    
NP_002 VSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLRDPAVCRSCDCDPMGSQDGGRCDSHDD
      370       380       390       400       410       420        

               400       410       420       430       440         
pF1KB4 P----VTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRR-DMPCDEES
       :    :.::: ::::: : ::. :. :: ::. ..  ::.::.::  :.   . ::: .:
NP_002 PALGLVSGQCRCKEHVVGTRCQQCRDGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPNS
      430       440       450       460       470       480        

      450       460       470        480       490       500       
pF1KB4 GRCLCLPNVVGPKCDQCAPYHWKLASGQ-GCEPCACDPHNSLSPQCNQFTGQCPCREGFG
       : : :   :.:  ::.: : :: :.    ::.:: ::  ..:.:::.. :::: ::. . 
NP_002 GSCYCKRLVTGRGCDRCLPGHWGLSHDLLGCRPCDCDVGGALDPQCDEGTGQCHCRQHMV
      490       500       510       520       530       540        

       510       520       530       540       550       560       
pF1KB4 GLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQC
       :  :                                                        
NP_002 GRRCEQVQPGYFRPFLDHLIWEAEDTRGQVLDVVERLVTPGETPSWTGSGFVRLQEGQTL
      550       560       570       580       590       600        

>--
 initn: 1115 init1: 382 opt: 1563  Z-score: 960.4  bits: 190.3 E(85289): 9.3e-47
Smith-Waterman score: 1563; 32.1% identity (58.4% similar) in 967 aa overlap (250-1172:877-1798)

     220       230       240       250       260       270         
pF1KB4 NFTRLAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVC
                                     : :.::::.:  . ::  :           
NP_002 SGQCLCRTGAFGLRCDRCQRGQWGFPSCRPCVCNGHADECNTHTGACLG-----------
        850       860       870       880       890                

     280       290       300       310        320       330        
pF1KB4 VCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDC-NGHSETCHFDPAVFAASQGA
        :. .:.: .::::   ... :  :  ::    :. : : .: .   ::   . .  :  
NP_002 -CRDHTGGEHCERCIAGFHGDPRLPYGGQ----CRPCPCPEGPGSQRHF---ATSCHQDE
          900       910       920           930          940       

      340         350       360        370       380         390   
pF1KB4 YGG--VCDNCRDHTEGKNCERCQLHYFRN-RRPGASIQETCISCEC--DPDGAVPGAPCD
       :.   :: .::    :  :: :   .: .  :::.     :  :::  . :   : : ::
NP_002 YSQQIVC-HCRAGYTGLRCEACAPGHFGDPSRPGGR----CQLCECSGNIDPMDPDA-CD
       950        960       970       980           990       1000 

           400        410       420       430        440           
pF1KB4 PVTGQCV-CKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSR-RDMP------CD
       : ::::. : .:..: .:  ::::: :   :  :.:::: ::.::.  .. :      ::
NP_002 PHTGQCLRCLHHTEGPHCAHCKPGFHG--QAARQSCHRCTCNLLGTNPQQCPSPDQCHCD
            1010      1020        1030      1040      1050         

         450       460       470       480       490       500     
pF1KB4 EESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREG
         ::.: ::::: ::.::.:::  :.:.::.::.:::: :  . .: ::.::::: :: :
NP_002 PSSGQCPCLPNVQGPSCDRCAPNFWNLTSGHGCQPCACHPSRARGPTCNEFTGQCHCRAG
    1060      1070      1080      1090      1100      1110         

         510       520       530       540       550       560     
pF1KB4 FGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCD
       :::  ::     .: .  .:: .  :.::::: :: . : : . .:.: ::::..: :::
NP_002 FGGRTCS-----ECQELHWGDPGLQCHACDCDSRGIDTPQCHRFTGHCSCRPGVSGVRCD
    1120           1130      1140      1150      1160      1170    

         570       580       590       600       610       620     
pF1KB4 QCQRGYCNRYPVCVACHPCFQTYDADLREQALRFGRLRNATASLWSGPGLEDRGLASRIL
       :: ::. . .:.:  :: ::  .:  ... : :  ::.. .  : .   :   .. : . 
NP_002 QCARGFSGIFPACHPCHACFGDWDRVVQDLAARTQRLEQRAQELQQTGVL--GAFESSFW
         1180      1190      1200      1210      1220        1230  

         630       640       650       660              670        
pF1KB4 DAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRRT-------LQGLQLDLP-LEEETLS
         . :.  .......  ..   .::.. :   :::        :  :. ::  ...:...
NP_002 HMQEKLGIVQGIVGARNTSAASTAQLVEATEELRREIGEATEHLTQLEADLTDVQDENFN
           1240      1250      1260      1270      1280      1290  

       680       690        700       710       720       730      
pF1KB4 LPRDLESLDRSFNGL-LTMYQRKREQFEKISSADPSGAFRMLSTAYEQSAQAAQQVSDSS
         . : .:.:.  .: ::. :   .... .. ..  ::.  .  :. :::.: .... :.
NP_002 ANHALSGLERDRLALNLTLRQLD-QHLDLLKHSNFLGAYDSIRHAHSQSAEAERRANTSA
           1300      1310       1320      1330      1340      1350 

        740        750       760       770       780               
pF1KB4 RLLDQ-LRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDLTPTF-----NKL-CG
         . . . .:    .:      .     . : .: .  ...:   : :.     :.: ::
NP_002 LAVPSPVSNSASARHRTEALMDAQKEDFNSKHMANQRALGKLSAHTHTLSLTDINELVCG
            1360      1370      1380      1390      1400      1410 

     790       800       810       820       830       840         
pF1KB4 NSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLRGFNAQLQRT
          .  :.   : :  : ...:     :: :.    .::   :  .  . :  .:.:::.
NP_002 APGDAPCATSPCGGAGCRDEDGQP---RCGGL--SCNGAAATADLALGRARHTQAELQRA
            1420      1430         1440        1450      1460      

     850              860       870       880       890       900  
pF1KB4 RQ-----MIRAAE--ESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLTDP
              . :.::  ..::. :. ::    ...:::.:.:.  .. . :::.:.:::.. 
NP_002 LAEGGSILSRVAETRRQASEAQQRAQAALDKANASRGQVEQANQELQELIQSVKDFLNQE
       1470      1480      1490      1500      1510      1520      

            910       920       930       940          950         
pF1KB4 DTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAAR---LPNVDLVLSQTKQDIARA
        .:  .:. :.  :: : .:. ::  .:..    ::: :   : .:: .:..:  :. ::
NP_002 GADPDSIEMVATRVLELSIPA-SAEQIQHLA--GAIAERVRSLADVDAILARTVGDVRRA
       1530      1540       1550        1560      1570      1580   

     960       970       980       990      1000      1010         
pF1KB4 RRLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQ
       ..:  .:..::: :.  . ..: : . :...  :   :: ...:.  . :  .. . .::
NP_002 EQLLQDARRARSWAEDEKQKAETVQAALEEAQRAQGIAQGAIRGAVADTRDTEQTLYQVQ
          1590      1600      1610      1620      1630      1640   

    1020      1030      1040      1050      1060      1070         
pF1KB4 QVLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFE
       . .  ::. ..:  ..  .. . .: :. .   ..  :  :.. : .:. .:  :.. ..
NP_002 ERMAGAERALSSAGERARQLDALLEALKLKRAGNSLAASTAEETAGSAQGRAQEAEQLLR
          1650      1660      1670      1680      1690      1700   

    1080          1090      1100      1110      1120      1130     
pF1KB4 R-IKQKYAELK---DRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLR
         . ..:  .:   .: .:. .:. : :: .... ::..:.  ... ..:....:    .
NP_002 GPLGDQYQTVKALAERKAQG-VLAAQ-ARAEQLRDEARDLLQAAQDKLQRLQELEGTYEE
          1710      1720        1730      1740      1750      1760 

        1140      1150      1160      1170  
pF1KB4 GSQAIMLRSADLTGLEKRVEQIRDHINGRVLYYATCK
       . .:.  ..:.: ::: :.... . :: .:  : ::.
NP_002 NERALESKAAQLDGLEARMRSVLQAINLQVQIYNTCQ
            1770      1780      1790        

>--
 initn: 357 init1: 207 opt: 364  Z-score: 235.6  bits: 56.2 E(85289): 2.2e-06
Smith-Waterman score: 364; 40.1% identity (61.3% similar) in 137 aa overlap (444-578:749-874)

           420       430       440       450       460       470   
pF1KB4 KPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLA
                                     : ::.     .:. ..:. . :::   .:.
NP_002 VLLPRVLVLEMFSGGDAAALERQATFERYQCHEEG----LVPSKTSPS-EACAPLLISLS
      720       730       740       750           760        770   

             480       490       500       510       520       530 
pF1KB4 S--GQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGC
       .   .:  :: :.:..::: .::   ::: :. :  :  :.      :    ::   :::
NP_002 TLIYNGALPCQCNPQGSLSSECNPHGGQCLCKPGVVGRRCDL-----CAPGYYGFGPTGC
           780       790       800       810            820        

             540       550       560       570       580       590 
pF1KB4 RACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDAD
       .::.:. .:. .  :.:.::.:::: :  : :::.::::  . .: :             
NP_002 QACQCSHEGALSSLCEKTSGQCLCRTGAFGLRCDRCQRGQWG-FPSCRPCVCNGHADECN
      830       840       850       860       870        880       

             600       610       620       630       640       650 
pF1KB4 LREQALRFGRLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQV
                                                                   
NP_002 THTGACLGCRDHTGGEHCERCIAGFHGDPRLPYGGQCRPCPCPEGPGSQRHFATSCHQDE
       890       900       910       920       930       940       

>>XP_005265184 (OMIM: 150325,609049,614199) PREDICTED: l  (1798 aa)
 initn: 1824 init1: 489 opt: 1258  Z-score: 776.1  bits: 156.2 E(85289): 1.7e-36
Smith-Waterman score: 1669; 45.1% identity (68.7% similar) in 514 aa overlap (21-511:42-552)

                         10        20        30        40        50
pF1KB4           MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLT
                                     ::::.::: .:::::::.  : :::::::.
XP_005 QPLPWELRLGLLLSVLAATLAQAPAPDVPGCSRGSCYPATGDLLVGRADRLTASSTCGLN
              20        30        40        50        60        70 

                60        70            80        90          100  
pF1KB4 KPETYC-TQYGEWQMKCCKCDSRQPH----NYYSHRVENVASSSGPMR---WWQSQNDVN
        :. :: ... . . ::  ::::.:     : .:::..::..: .:.:   ::::.: . 
XP_005 GPQPYCIVSHLQDEKKCFLCDSRRPFSARDNPHSHRIQNVVTSFAPQRRAAWWQSENGIP
              80        90       100       110       120       130 

            110       120       130       140       150       160  
pF1KB4 PVSLQLDLDRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQ
        :..::::. .:.. ...: :.   ::.::.:::.:::.::.::.:.. :: . :: :  
XP_005 AVTIQLDLEAEFHFTHLIMTFKTFRPAAMLVERSADFGRTWHVYRYFSYDCGADFPGVPL
             140       150       160       170       180       190 

            170       180       190       200       210       220  
pF1KB4 GRPQSWQDVRCQSLPQRPNARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFT
       . :. :.:: :.:  .. .   .: .:   ..: .  ::   :..::.. .:::::::.:
XP_005 APPRHWDDVVCESRYSEIEPSTEG-EVIYRVLDPAIPIPDPYSSRIQNLLKITNLRVNLT
             200       210        220       230       240       250

            230            240       250       260       270       
pF1KB4 RLAPVPQRGYHP-----PSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHD
       ::  . .    :      . :::. .: ..:.:::.:::..::: ::: :   .  .:: 
XP_005 RLHTLGDNLLDPRREIREKYYYALYELVVRGNCFCYGHASECAPAPGAPA--HAEGMVHG
              260       270       280       290       300          

       280       290       300       310       320       330       
pF1KB4 VCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQG
       .:.:.::: : :::.:  :: . ::::::   .: :..:.:.::...:::: ::. :: .
XP_005 ACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSHACRKCECHGHTHSCHFDMAVYLASGN
      310       320       330       340       350       360        

       340       350       360       370       380       390       
pF1KB4 AYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCD----
       . :::::.:. .: :..:: :.  ..:.         .: ::.::: :.  :. ::    
XP_005 VSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLRDPAVCRSCDCDPMGSQDGGRCDSHDD
      370       380       390       400       410       420        

               400       410       420       430       440         
pF1KB4 P----VTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRR-DMPCDEES
       :    :.::: ::::: : ::. :. :: ::. ..  ::.::.::  :.   . ::: .:
XP_005 PALGLVSGQCRCKEHVVGTRCQQCRDGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPNS
      430       440       450       460       470       480        

      450       460       470        480       490       500       
pF1KB4 GRCLCLPNVVGPKCDQCAPYHWKLASGQ-GCEPCACDPHNSLSPQCNQFTGQCPCREGFG
       : : :   :.:  ::.: : :: :.    ::.:: ::  ..:.:::.. :::: ::. . 
XP_005 GSCYCKRLVTGRGCDRCLPGHWGLSHDLLGCRPCDCDVGGALDPQCDEGTGQCHCRQHMV
      490       500       510       520       530       540        

       510       520       530       540       550       560       
pF1KB4 GLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQC
       :  :                                                        
XP_005 GRRCEQVQPGYFRPFLDHLIWEAEDTRGQVLDVVERLVTPGETPSWTGSGFVRLQEGQTL
      550       560       570       580       590       600        

>--
 initn: 1115 init1: 382 opt: 1563  Z-score: 960.4  bits: 190.3 E(85289): 9.3e-47
Smith-Waterman score: 1563; 32.1% identity (58.4% similar) in 967 aa overlap (250-1172:877-1798)

     220       230       240       250       260       270         
pF1KB4 NFTRLAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVC
                                     : :.::::.:  . ::  :           
XP_005 SGQCLCRTGAFGLRCDRCQRGQWGFPSCRPCVCNGHADECNTHTGACLG-----------
        850       860       870       880       890                

     280       290       300       310        320       330        
pF1KB4 VCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDC-NGHSETCHFDPAVFAASQGA
        :. .:.: .::::   ... :  :  ::    :. : : .: .   ::   . .  :  
XP_005 -CRDHTGGEHCERCIAGFHGDPRLPYGGQ----CRPCPCPEGPGSQRHF---ATSCHQDE
          900       910       920           930          940       

      340         350       360        370       380         390   
pF1KB4 YGG--VCDNCRDHTEGKNCERCQLHYFRN-RRPGASIQETCISCEC--DPDGAVPGAPCD
       :.   :: .::    :  :: :   .: .  :::.     :  :::  . :   : : ::
XP_005 YSQQIVC-HCRAGYTGLRCEACAPGHFGDPSRPGGR----CQLCECSGNIDPMDPDA-CD
       950        960       970       980           990       1000 

           400        410       420       430        440           
pF1KB4 PVTGQCV-CKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSR-RDMP------CD
       : ::::. : .:..: .:  ::::: :   :  :.:::: ::.::.  .. :      ::
XP_005 PHTGQCLRCLHHTEGPHCAHCKPGFHG--QAARQSCHRCTCNLLGTNPQQCPSPDQCHCD
            1010      1020        1030      1040      1050         

         450       460       470       480       490       500     
pF1KB4 EESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREG
         ::.: ::::: ::.::.:::  :.:.::.::.:::: :  . .: ::.::::: :: :
XP_005 PSSGQCPCLPNVQGPSCDRCAPNFWNLTSGHGCQPCACHPSRARGPTCNEFTGQCHCRAG
    1060      1070      1080      1090      1100      1110         

         510       520       530       540       550       560     
pF1KB4 FGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCD
       :::  ::     .: .  .:: .  :.::::: :: . : : . .:.: ::::..: :::
XP_005 FGGRTCS-----ECQELHWGDPGLQCHACDCDSRGIDTPQCHRFTGHCSCRPGVSGVRCD
    1120           1130      1140      1150      1160      1170    

         570       580       590       600       610       620     
pF1KB4 QCQRGYCNRYPVCVACHPCFQTYDADLREQALRFGRLRNATASLWSGPGLEDRGLASRIL
       :: ::. . .:.:  :: ::  .:  ... : :  ::.. .  : .   :   .. : . 
XP_005 QCARGFSGIFPACHPCHACFGDWDRVVQDLAARTQRLEQRAQELQQTGVL--GAFESSFW
         1180      1190      1200      1210      1220        1230  

         630       640       650       660              670        
pF1KB4 DAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRRT-------LQGLQLDLP-LEEETLS
         . :.  .......  ..   .::.. :   :::        :  :. ::  ...:...
XP_005 HMQEKLGIVQGIVGARNTSAASTAQLVEATEELRREIGEATEHLTQLEADLTDVQDENFN
           1240      1250      1260      1270      1280      1290  

       680       690        700       710       720       730      
pF1KB4 LPRDLESLDRSFNGL-LTMYQRKREQFEKISSADPSGAFRMLSTAYEQSAQAAQQVSDSS
         . : .:.:.  .: ::. :   .... .. ..  ::.  .  :. :::.: .... :.
XP_005 ANHALSGLERDRLALNLTLRQLD-QHLDLLKHSNFLGAYDSIRHAHSQSAEAERRANTSA
           1300      1310       1320      1330      1340      1350 

        740        750       760       770       780               
pF1KB4 RLLDQ-LRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDLTPTF-----NKL-CG
         . . . .:    .:      .     . : .: .  ...:   : :.     :.: ::
XP_005 LAVPSPVSNSASARHRTEALMDAQKEDFNSKHMANQRALGKLSAHTHTLSLTDINELVCG
            1360      1370      1380      1390      1400      1410 

     790       800       810       820       830       840         
pF1KB4 NSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLRGFNAQLQRT
          .  :.   : :  : ...:     :: :.    .::   :  .  . :  .:.:::.
XP_005 APGDAPCATSPCGGAGCRDEDGQP---RCGGL--SCNGAAATADLALGRARHTQAELQRA
            1420      1430         1440        1450      1460      

     850              860       870       880       890       900  
pF1KB4 RQ-----MIRAAE--ESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLTDP
              . :.::  ..::. :. ::    ...:::.:.:.  .. . :::.:.:::.. 
XP_005 LAEGGSILSRVAETRRQASEAQQRAQAALDKANASRGQVEQANQELQELIQSVKDFLNQE
       1470      1480      1490      1500      1510      1520      

            910       920       930       940          950         
pF1KB4 DTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAAR---LPNVDLVLSQTKQDIARA
        .:  .:. :.  :: : .:. ::  .:..    ::: :   : .:: .:..:  :. ::
XP_005 GADPDSIEMVATRVLELSIPA-SAEQIQHLA--GAIAERVRSLADVDAILARTVGDVRRA
       1530      1540       1550        1560      1570      1580   

     960       970       980       990      1000      1010         
pF1KB4 RRLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQ
       ..:  .:..::: :.  . ..: : . :...  :   :: ...:.  . :  .. . .::
XP_005 EQLLQDARRARSWAEDEKQKAETVQAALEEAQRAQGIAQGAIRGAVADTRDTEQTLYQVQ
          1590      1600      1610      1620      1630      1640   

    1020      1030      1040      1050      1060      1070         
pF1KB4 QVLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFE
       . .  ::. ..:  ..  .. . .: :. .   ..  :  :.. : .:. .:  :.. ..
XP_005 ERMAGAERALSSAGERARQLDALLEALKLKRAGNSLAASTAEETAGSAQGRAQEAEQLLR
          1650      1660      1670      1680      1690      1700   

    1080          1090      1100      1110      1120      1130     
pF1KB4 R-IKQKYAELK---DRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLR
         . ..:  .:   .: .:. .:. : :: .... ::..:.  ... ..:....:    .
XP_005 GPLGDQYQTVKALAERKAQG-VLAAQ-ARAEQLRDEARDLLQAAQDKLQRLQELEGTYEE
          1710      1720        1730      1740      1750      1760 

        1140      1150      1160      1170  
pF1KB4 GSQAIMLRSADLTGLEKRVEQIRDHINGRVLYYATCK
       . .:.  ..:.: ::: :.... . :: .:  : ::.
XP_005 NERALESKAAQLDGLEARMRSVLQAINLQVQIYNTCQ
            1770      1780      1790        

>--
 initn: 357 init1: 207 opt: 364  Z-score: 235.6  bits: 56.2 E(85289): 2.2e-06
Smith-Waterman score: 364; 40.1% identity (61.3% similar) in 137 aa overlap (444-578:749-874)

           420       430       440       450       460       470   
pF1KB4 KPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLA
                                     : ::.     .:. ..:. . :::   .:.
XP_005 VLLPRVLVLEMFSGGDAAALERQATFERYQCHEEG----LVPSKTSPS-EACAPLLISLS
      720       730       740       750           760        770   

             480       490       500       510       520       530 
pF1KB4 S--GQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGC
       .   .:  :: :.:..::: .::   ::: :. :  :  :.      :    ::   :::
XP_005 TLIYNGALPCQCNPQGSLSSECNPHGGQCLCKPGVVGRRCDL-----CAPGYYGFGPTGC
           780       790       800       810            820        

             540       550       560       570       580       590 
pF1KB4 RACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDAD
       .::.:. .:. .  :.:.::.:::: :  : :::.::::  . .: :             
XP_005 QACQCSHEGALSSLCEKTSGQCLCRTGAFGLRCDRCQRGQWG-FPSCRPCVCNGHADECN
      830       840       850       860       870        880       

             600       610       620       630       640       650 
pF1KB4 LREQALRFGRLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQV
                                                                   
XP_005 THTGACLGCRDHTGGEHCERCIAGFHGDPRLPYGGQCRPCPCPEGPGSQRHFATSCHQDE
       890       900       910       920       930       940       

>>NP_001304977 (OMIM: 616380) laminin subunit beta-4 iso  (772 aa)
 initn: 1568 init1: 505 opt: 1251  Z-score: 776.0  bits: 155.0 E(85289): 1.7e-36
Smith-Waterman score: 1609; 43.2% identity (67.6% similar) in 525 aa overlap (17-515:19-540)

                 10        20        30        40        50        
pF1KB4   MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCT-
                         ::. :.::::.: .:::::::.  : :::::::.. . ::  
NP_001 MQFQLTLFLHLGWLSYSKAQDDCNRGACHPTTGDLLVGRNTQLMASSTCGLSRAQKYCIL
               10        20        30        40        50        60

        60        70            80        90          100       110
pF1KB4 QYGEWQMKCCKCDSRQPHNYY----SHRVENVASSSGPMR---WWQSQNDVNPVSLQLDL
       .: : ..::  :::: :.. :    :: .:::  :  : :   ::::.: .. ::..:::
NP_001 SYLEGEQKCFICDSRFPYDPYDQPNSHTIENVIVSFEPDREKKWWQSENGLDHVSIRLDL
               70        80        90       100       110       120

              120       130       140       150       160       170
pF1KB4 DRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQD
       .  :....... :.   ::.::.:::.:.:..:.:..:.: ::...:: . .:. :.  :
NP_001 EALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFPNITSGQAQGVGD
              130       140       150       160       170       180

                180       190       200       210       220        
pF1KB4 VRCQSLPQ--RPNARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVP
       . :.:  .  .:..   ::.: :...:    :    :  ::..  .::::.:::.:  . 
NP_001 IVCDSKYSDIEPST---GGEVVLKVLDPSFEIENPYSPYIQDLVTLTNLRINFTKLHTLG
              190          200       210       220       230       

      230             240       250       260        270       280 
pF1KB4 QR--GYHPPSA----YYAVSQLRLQGSCFCHGHADRCAPKPGASAGP-STAVQVHDVCVC
       .   : .  ..    :::. .. ..:::::.:::..: :     .   :   .::  :::
NP_001 DALLGRRQNDSLDKYYYALYEMIVRGSCFCNGHASECRPMQKMRGDVFSPPGMVHGQCVC
       240       250       260       270       280       290       

             290       300       310       320       330       340 
pF1KB4 QHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGG
       :::: :::::::  :... :::::   . . :. :.::.::  :::: ... :: :  ::
NP_001 QHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSCSCNSHSSRCHFDMTTYLASGGLSGG
       300       310       320       330       340       350       

             350       360       370       380       390           
pF1KB4 VCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPC----DP---
       ::..:. .:::..:.::.  ..:.     :   .:: :::::::.. :. :    ::   
NP_001 VCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPDGTISGGICVSHSDPALG
       360       370       380       390       400       410       

           400       410       420       430       440       450   
pF1KB4 -VTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLC
        :.:::.:::.:.: .:: :::.  ::. ..: ::. :::: :::   . :: ..:.:::
NP_001 SVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLC
       420       430       440       450       460       470       

           460       470        480       490       500       510  
pF1KB4 LPNVVGPKCDQCAPYHWKLASG-QGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCS
       :  :.: .:..:.  .: :..  .:: :: ::  .. :  :.  .::: ::    :  ::
NP_001 LSYVTGAHCEECTVGYWGLGNHLHGCSPCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCS
       480       490       500       510       520       530       

            520       530       540       550       560       570  
pF1KB4 AAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYC
         :                                                         
NP_001 EPAPGYFFAPLNFYLYEAEEATTLQGLAPLGSETFGQSPAVHVVLGEPVPGNPVTWTGPG
       540       550       560       570       580       590       

>>NP_001304976 (OMIM: 616380) laminin subunit beta-4 iso  (1101 aa)
 initn: 1474 init1: 505 opt: 1251  Z-score: 774.3  bits: 155.1 E(85289): 2.2e-36
Smith-Waterman score: 1609; 43.2% identity (67.6% similar) in 525 aa overlap (17-515:19-540)

                 10        20        30        40        50        
pF1KB4   MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCT-
                         ::. :.::::.: .:::::::.  : :::::::.. . ::  
NP_001 MQFQLTLFLHLGWLSYSKAQDDCNRGACHPTTGDLLVGRNTQLMASSTCGLSRAQKYCIL
               10        20        30        40        50        60

        60        70            80        90          100       110
pF1KB4 QYGEWQMKCCKCDSRQPHNYY----SHRVENVASSSGPMR---WWQSQNDVNPVSLQLDL
       .: : ..::  :::: :.. :    :: .:::  :  : :   ::::.: .. ::..:::
NP_001 SYLEGEQKCFICDSRFPYDPYDQPNSHTIENVIVSFEPDREKKWWQSENGLDHVSIRLDL
               70        80        90       100       110       120

              120       130       140       150       160       170
pF1KB4 DRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQD
       .  :....... :.   ::.::.:::.:.:..:.:..:.: ::...:: . .:. :.  :
NP_001 EALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFPNITSGQAQGVGD
              130       140       150       160       170       180

                180       190       200       210       220        
pF1KB4 VRCQSLPQ--RPNARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVP
       . :.:  .  .:..   ::.: :...:    :    :  ::..  .::::.:::.:  . 
NP_001 IVCDSKYSDIEPST---GGEVVLKVLDPSFEIENPYSPYIQDLVTLTNLRINFTKLHTLG
              190          200       210       220       230       

      230             240       250       260        270       280 
pF1KB4 QR--GYHPPSA----YYAVSQLRLQGSCFCHGHADRCAPKPGASAGP-STAVQVHDVCVC
       .   : .  ..    :::. .. ..:::::.:::..: :     .   :   .::  :::
NP_001 DALLGRRQNDSLDKYYYALYEMIVRGSCFCNGHASECRPMQKMRGDVFSPPGMVHGQCVC
       240       250       260       270       280       290       

             290       300       310       320       330       340 
pF1KB4 QHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGG
       :::: :::::::  :... :::::   . . :. :.::.::  :::: ... :: :  ::
NP_001 QHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSCSCNSHSSRCHFDMTTYLASGGLSGG
       300       310       320       330       340       350       

             350       360       370       380       390           
pF1KB4 VCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPC----DP---
       ::..:. .:::..:.::.  ..:.     :   .:: :::::::.. :. :    ::   
NP_001 VCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPDGTISGGICVSHSDPALG
       360       370       380       390       400       410       

           400       410       420       430       440       450   
pF1KB4 -VTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLC
        :.:::.:::.:.: .:: :::.  ::. ..: ::. :::: :::   . :: ..:.:::
NP_001 SVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLC
       420       430       440       450       460       470       

           460       470        480       490       500       510  
pF1KB4 LPNVVGPKCDQCAPYHWKLASG-QGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCS
       :  :.: .:..:.  .: :..  .:: :: ::  .. :  :.  .::: ::    :  ::
NP_001 LSYVTGAHCEECTVGYWGLGNHLHGCSPCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCS
       480       490       500       510       520       530       

            520       530       540       550       560       570  
pF1KB4 AAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYC
         :                                                         
NP_001 EPAPGYFFAPLNFYLYEAEEATTLQGLAPLGSETFGQSPAVHVVLGEPVPGNPVTWTGPG
       540       550       560       570       580       590       

>--
 initn: 484 init1: 237 opt: 527  Z-score: 336.6  bits: 74.2 E(85289): 5.2e-12
Smith-Waterman score: 527; 33.6% identity (55.0% similar) in 289 aa overlap (233-495:820-1094)

            210       220       230       240       250            
pF1KB4 TQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHA-----D
                                     :: ..  .: . .. :.: :::..     :
NP_001 CKPLVVGRCCDRCSTGSYDLGHHGCHPCHCHPQGSKDTVCD-QVTGQCPCHGEVSGRRCD
     790       800       810       820       830        840        

        260        270               280       290        300      
pF1KB4 RC-APKPG-ASAGPSTAVQVHDVC--------VCQHNTAGPNCERCAP-FYNNRPWRPAE
       :: :   :  :  :    .  ..:         :   :.: :::::   .:.:    :. 
NP_001 RCLAGYFGFPSCHPCPCNRFAELCDPETGSCFNCGGFTTGRNCERCIDGYYGN----PSS
      850       860       870       880       890       900        

        310        320       330       340       350       360     
pF1KB4 GQDAHECQRCDC-NGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRN
       ::    :. : : .  : . .:  . .    ..   .: :: .   : .: .:.  .. :
NP_001 GQP---CRPCLCPDDPSSNQYFAHSCYQNLWSS-DVIC-NCLQGYTGTQCGECSTGFYGN
             910       920       930         940       950         

         370       380       390       400        410       420    
pF1KB4 RRPGASIQETCISCECDPDGAVPGAPCDPVTGQCV-CKEHVQGERCDLCKPGFTGLTYAN
        : ...  . : .:. . : . :   :. :::.:. : ...::  :.:::::  :   : 
NP_001 PRISGAPCQPC-ACNNNIDVTDP-ESCSRVTGECLRCLHNTQGANCQLCKPGHYG--SAL
     960       970        980        990      1000      1010       

          430        440              450       460       470      
pF1KB4 PQGCHRCDCNILG-SRRDMP-------CDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQ
        : :.::.:.  : :  . :       ::  .: : :::::.:  ::.::  .:.:. :.
NP_001 NQTCRRCSCHASGVSPMECPPGGGACLCDPVTGACPCLPNVTGLACDRCADGYWNLVPGR
        1020      1030      1040      1050      1060      1070     

        480       490       500       510       520       530      
pF1KB4 GCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDC
       ::. : :::..: : .:.:                                         
NP_001 GCQSCDCDPRTSQSSHCDQARYFKAY                                  
        1080      1090      1100                                   

>>XP_011514282 (OMIM: 616380) PREDICTED: laminin subunit  (1564 aa)
 initn: 1665 init1: 505 opt: 1251  Z-score: 772.5  bits: 155.3 E(85289): 2.7e-36
Smith-Waterman score: 1609; 43.2% identity (67.6% similar) in 525 aa overlap (17-515:19-540)

                 10        20        30        40        50        
pF1KB4   MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCT-
                         ::. :.::::.: .:::::::.  : :::::::.. . ::  
XP_011 MQFQLTLFLHLGWLSYSKAQDDCNRGACHPTTGDLLVGRNTQLMASSTCGLSRAQKYCIL
               10        20        30        40        50        60

        60        70            80        90          100       110
pF1KB4 QYGEWQMKCCKCDSRQPHNYY----SHRVENVASSSGPMR---WWQSQNDVNPVSLQLDL
       .: : ..::  :::: :.. :    :: .:::  :  : :   ::::.: .. ::..:::
XP_011 SYLEGEQKCFICDSRFPYDPYDQPNSHTIENVIVSFEPDREKKWWQSENGLDHVSIRLDL
               70        80        90       100       110       120

              120       130       140       150       160       170
pF1KB4 DRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQD
       .  :....... :.   ::.::.:::.:.:..:.:..:.: ::...:: . .:. :.  :
XP_011 EALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFPNITSGQAQGVGD
              130       140       150       160       170       180

                180       190       200       210       220        
pF1KB4 VRCQSLPQ--RPNARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVP
       . :.:  .  .:..   ::.: :...:    :    :  ::..  .::::.:::.:  . 
XP_011 IVCDSKYSDIEPST---GGEVVLKVLDPSFEIENPYSPYIQDLVTLTNLRINFTKLHTLG
              190          200       210       220       230       

      230             240       250       260        270       280 
pF1KB4 QR--GYHPPSA----YYAVSQLRLQGSCFCHGHADRCAPKPGASAGP-STAVQVHDVCVC
       .   : .  ..    :::. .. ..:::::.:::..: :     .   :   .::  :::
XP_011 DALLGRRQNDSLDKYYYALYEMIVRGSCFCNGHASECRPMQKMRGDVFSPPGMVHGQCVC
       240       250       260       270       280       290       

             290       300       310       320       330       340 
pF1KB4 QHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGG
       :::: :::::::  :... :::::   . . :. :.::.::  :::: ... :: :  ::
XP_011 QHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSCSCNSHSSRCHFDMTTYLASGGLSGG
       300       310       320       330       340       350       

             350       360       370       380       390           
pF1KB4 VCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPC----DP---
       ::..:. .:::..:.::.  ..:.     :   .:: :::::::.. :. :    ::   
XP_011 VCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPDGTISGGICVSHSDPALG
       360       370       380       390       400       410       

           400       410       420       430       440       450   
pF1KB4 -VTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLC
        :.:::.:::.:.: .:: :::.  ::. ..: ::. :::: :::   . :: ..:.:::
XP_011 SVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLC
       420       430       440       450       460       470       

           460       470        480       490       500       510  
pF1KB4 LPNVVGPKCDQCAPYHWKLASG-QGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCS
       :  :.: .:..:.  .: :..  .:: :: ::  .. :  :.  .::: ::    :  ::
XP_011 LSYVTGAHCEECTVGYWGLGNHLHGCSPCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCS
       480       490       500       510       520       530       

            520       530       540       550       560       570  
pF1KB4 AAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYC
         :                                                         
XP_011 EPAPGYFFAPLNFYLYEAEEATTLQGLAPLGSETFGQSPAVHVVLGEPVPGNPVTWTGPG
       540       550       560       570       580       590       

>--
 initn: 737 init1: 335 opt: 1180  Z-score: 729.6  bits: 147.4 E(85289): 6.7e-34
Smith-Waterman score: 1180; 28.2% identity (56.6% similar) in 776 aa overlap (233-971:820-1561)

            210       220       230       240       250            
pF1KB4 TQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHA-----D
                                     :: ..  .: . .. :.: :::..     :
XP_011 CKPLVVGRCCDRCSTGSYDLGHHGCHPCHCHPQGSKDTVCD-QVTGQCPCHGEVSGRRCD
     790       800       810       820       830        840        

        260        270               280       290        300      
pF1KB4 RC-APKPG-ASAGPSTAVQVHDVC--------VCQHNTAGPNCERCAP-FYNNRPWRPAE
       :: :   :  :  :    .  ..:         :   :.: :::::   .:.:    :. 
XP_011 RCLAGYFGFPSCHPCPCNRFAELCDPETGSCFNCGGFTTGRNCERCIDGYYGN----PSS
      850       860       870       880       890       900        

        310       320       330         340         350       360  
pF1KB4 GQDAHECQRCDCNGHSETCHFDPAVFAAS--QGAYGG--VCDNCRDHTEGKNCERCQLHY
       ::    :. : :     . ..    :: :  :. ...  .: :: .   : .: .:.  .
XP_011 GQP---CRPCLCPDDPSSNQY----FAHSCYQNLWSSDVIC-NCLQGYTGTQCGECSTGF
             910       920           930        940       950      

            370       380       390       400        410       420 
pF1KB4 FRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCV-CKEHVQGERCDLCKPGFTGLT
       . : : ...  . : .:. . : . : . :. :::.:. : ...::  :.:::::  :  
XP_011 YGNPRISGAPCQPC-ACNNNIDVTDPES-CSRVTGECLRCLHNTQGANCQLCKPGHYG--
        960       970        980        990      1000      1010    

             430        440              450       460       470   
pF1KB4 YANPQGCHRCDCNILG-SRRDMP-------CDEESGRCLCLPNVVGPKCDQCAPYHWKLA
        :  : :.::.:.  : :  . :       ::  .: : :::::.:  ::.::  .:.:.
XP_011 SALNQTCRRCSCHASGVSPMECPPGGGACLCDPVTGACPCLPNVTGLACDRCADGYWNLV
           1020      1030      1040      1050      1060      1070  

           480       490       500       510       520       530   
pF1KB4 SGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRA
        :.::. : :::..: : .:.:.::::::. :.::  ::     .: .  :::    :  
XP_011 PGRGCQSCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCS-----ECQENYYGDPPGRCIP
           1080      1090      1100      1110           1120       

           540       550       560       570       580       590   
pF1KB4 CDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLR
       :::.  ::. : ::  .: : :: :..: :::.: ::. ...:.:. :: ::. .:  . 
XP_011 CDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGHSQEFPTCLQCHLCFDQWDHTI-
      1130      1140      1150      1160      1170      1180       

           600       610        620            630       640       
pF1KB4 EQALRFGRLRNATASLWS-GPGLEDRGLASRILDA-----KSKIEQIRAVLSSPAVTEQE
             . : .:. .:   . ..::.  .  . .:     .... .:. .:. :.    .
XP_011 ------SSLSKAVQGLMRLAANMEDKRETLPVCEADFKDLRGNVSEIERILKHPVFPSGK
             1190      1200      1210      1220      1230      1240

       650       660       670       680       690       700       
pF1KB4 VAQVASAILSLRRTLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKIS
         .: .   :.:: .. :. .:    :  .:   .:      . ::   :.. .   .. 
XP_011 FLKVKDYHDSVRRQIMQLNEQLKAVYEFQDLKDTIERAKNEADLLLEDLQEEIDLQSSVL
             1250      1260      1270      1280      1290      1300

       710       720       730       740       750       760       
pF1KB4 SADPSGAFRMLSTAYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKL
       .:. . . . ..  :. :..: ......:  ..   ..: .   ..    . :.     :
XP_011 NASIADSSENIKKYYHISSSAEKKINETSSTINTSANTRNDLLTILDTLTSKGN-----L
             1310      1320      1330      1340      1350          

       770       780       790       800       810         820     
pF1KB4 VALRLEMSSLPDLTPTFNKLCGNSRQMACTPISCPGELCPQDNG-TAC-GSRCRGVLPRA
          ::.. ..::.    .:.::.  .. :.:. : : ::   .:   : :  :.: :  .
XP_011 SLERLKQIKIPDIQILNEKVCGDPGNVPCVPLPCGGALCTGRKGHRKCRGPGCHGSLTLS
        1360      1370      1380      1390      1400      1410     

         830       840       850       860       870       880     
pF1KB4 GGAFLMAGQVAEQLRGFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDV
        .:.  : ..   .:... :..  ...:..  :.:   ...: .:. ...  :.: . . 
XP_011 TNALQKAQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNALQLREKLGNIRNQSDSEE
        1420      1430      1440      1450      1460      1470     

         890       900       910       920       930       940     
pF1KB4 RRTRLLIQQVRDFLTDPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNV
       .   :.:..:..:: . ..    :..:...:: . ::  : .. ... .::       . 
XP_011 ENINLFIKKVKNFLLEENVPPEDIEKVANGVLDIHLPIPSQNLTDELVKIQKHMQLCEDY
        1480      1490      1500      1510      1520      1530     

         950       960       970       980       990      1000     
pF1KB4 DLVLSQTKQDIARARRLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTS
           .. ...   :..: ..:. :..                                  
XP_011 RTDENRLNEEADGAQKLLVKAKAAENLLS                               
        1540      1550      1560                                   




1172 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 21:45:14 2016 done: Thu Nov  3 21:45:17 2016
 Total Scan time: 16.350 Total Display time:  0.570

Function used was FASTA [36.3.4 Apr, 2011]
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