FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4828, 291 aa 1>>>pF1KB4828 291 - 291 aa - 291 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1806+/-0.000305; mu= 12.0354+/- 0.019 mean_var=92.9501+/-19.010, 0's: 0 Z-trim(119.2): 75 B-trim: 2716 in 2/56 Lambda= 0.133030 statistics sampled from 32924 (33017) to 32924 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.743), E-opt: 0.2 (0.387), width: 16 Scan time: 4.900 The best scores are: opt bits E(85289) NP_659458 (OMIM: 613335) E3 ubiquitin-protein liga ( 291) 2010 395.3 7.3e-110 XP_016871383 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 291) 2010 395.3 7.3e-110 XP_011537797 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 291) 2010 395.3 7.3e-110 NP_001002266 (OMIM: 613335) E3 ubiquitin-protein l ( 291) 2010 395.3 7.3e-110 XP_011537794 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 1536 304.5 3.1e-82 XP_011537795 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 1536 304.5 3.1e-82 XP_011537796 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 1536 304.5 3.1e-82 NP_001269795 (OMIM: 613335) E3 ubiquitin-protein l ( 573) 1536 304.5 3.1e-82 XP_005271861 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 1536 304.5 3.1e-82 XP_006717767 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 1536 304.5 3.1e-82 XP_016863825 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 285) 1335 265.7 7.1e-71 XP_016863824 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 285) 1335 265.7 7.1e-71 XP_016863823 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 289) 1246 248.7 1e-65 NP_001159845 (OMIM: 613331) E3 ubiquitin-protein l ( 289) 1246 248.7 1e-65 NP_060393 (OMIM: 613331) E3 ubiquitin-protein liga ( 272) 1190 237.9 1.6e-62 XP_011530357 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 545) 1125 225.6 1.6e-58 XP_016882342 (OMIM: 613332) PREDICTED: E3 ubiquiti ( 246) 322 71.3 2.1e-12 NP_057580 (OMIM: 613332) E3 ubiquitin-protein liga ( 246) 322 71.3 2.1e-12 NP_001005415 (OMIM: 613332) E3 ubiquitin-protein l ( 246) 322 71.3 2.1e-12 XP_011526348 (OMIM: 613332) PREDICTED: E3 ubiquiti ( 256) 305 68.0 2.1e-11 XP_011526349 (OMIM: 613332) PREDICTED: E3 ubiquiti ( 256) 305 68.0 2.1e-11 NP_848545 (OMIM: 613333) E3 ubiquitin-protein liga ( 253) 293 65.7 1e-10 XP_016864504 (OMIM: 613333) PREDICTED: E3 ubiquiti ( 154) 268 60.8 1.9e-09 XP_011541431 (OMIM: 613333) PREDICTED: E3 ubiquiti ( 280) 267 60.8 3.5e-09 XP_011541432 (OMIM: 613333) PREDICTED: E3 ubiquiti ( 280) 267 60.8 3.5e-09 XP_011541433 (OMIM: 613333) PREDICTED: E3 ubiquiti ( 280) 267 60.8 3.5e-09 XP_006722826 (OMIM: 613332) PREDICTED: E3 ubiquiti ( 176) 262 59.7 4.7e-09 NP_001005416 (OMIM: 613332) E3 ubiquitin-protein l ( 176) 262 59.7 4.7e-09 NP_612405 (OMIM: 613336) E3 ubiquitin-protein liga ( 346) 264 60.2 6.3e-09 XP_016864433 (OMIM: 613297) PREDICTED: E3 ubiquiti ( 460) 260 59.5 1.4e-08 NP_065865 (OMIM: 608208) E3 ubiquitin-protein liga ( 410) 259 59.3 1.4e-08 XP_011512238 (OMIM: 613297) PREDICTED: E3 ubiquiti ( 637) 260 59.6 1.8e-08 XP_011512236 (OMIM: 613297) PREDICTED: E3 ubiquiti ( 791) 260 59.7 2.1e-08 NP_005876 (OMIM: 613297) E3 ubiquitin-protein liga ( 910) 260 59.7 2.4e-08 NP_001257589 (OMIM: 613297) E3 ubiquitin-protein l ( 862) 257 59.1 3.4e-08 NP_001096032 (OMIM: 613338) E3 ubiquitin-protein l ( 402) 252 58.0 3.5e-08 XP_005257163 (OMIM: 613337) PREDICTED: probable E3 ( 752) 217 51.4 6.2e-06 NP_001275709 (OMIM: 613337) probable E3 ubiquitin- ( 799) 217 51.4 6.5e-06 XP_005257160 (OMIM: 613337) PREDICTED: probable E3 ( 799) 217 51.4 6.5e-06 XP_011522739 (OMIM: 613337) PREDICTED: probable E3 ( 807) 217 51.4 6.6e-06 NP_689811 (OMIM: 613337) probable E3 ubiquitin-pro ( 808) 217 51.4 6.6e-06 NP_001094345 (OMIM: 613337) probable E3 ubiquitin- ( 808) 217 51.4 6.6e-06 XP_005257159 (OMIM: 613337) PREDICTED: probable E3 ( 824) 217 51.4 6.7e-06 XP_011522738 (OMIM: 613337) PREDICTED: probable E3 ( 825) 217 51.4 6.7e-06 XP_005257157 (OMIM: 613337) PREDICTED: probable E3 ( 825) 217 51.4 6.7e-06 NP_001275708 (OMIM: 613337) probable E3 ubiquitin- ( 846) 217 51.5 6.8e-06 XP_011522737 (OMIM: 613337) PREDICTED: probable E3 ( 862) 217 51.5 6.9e-06 XP_005257155 (OMIM: 613337) PREDICTED: probable E3 ( 862) 217 51.5 6.9e-06 XP_005257152 (OMIM: 613337) PREDICTED: probable E3 ( 863) 217 51.5 6.9e-06 XP_005257153 (OMIM: 613337) PREDICTED: probable E3 ( 863) 217 51.5 6.9e-06 >>NP_659458 (OMIM: 613335) E3 ubiquitin-protein ligase M (291 aa) initn: 2010 init1: 2010 opt: 2010 Z-score: 2093.4 bits: 395.3 E(85289): 7.3e-110 Smith-Waterman score: 2010; 100.0% identity (100.0% similar) in 291 aa overlap (1-291:1-291) 10 20 30 40 50 60 pF1KB4 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_659 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 PAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_659 PAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 RCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_659 RCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 AEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_659 AEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQN 190 200 210 220 230 240 250 260 270 280 290 pF1KB4 CPETSKKNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_659 CPETSKKNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV 250 260 270 280 290 >>XP_016871383 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr (291 aa) initn: 2010 init1: 2010 opt: 2010 Z-score: 2093.4 bits: 395.3 E(85289): 7.3e-110 Smith-Waterman score: 2010; 100.0% identity (100.0% similar) in 291 aa overlap (1-291:1-291) 10 20 30 40 50 60 pF1KB4 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 PAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 RCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 AEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQN 190 200 210 220 230 240 250 260 270 280 290 pF1KB4 CPETSKKNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CPETSKKNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV 250 260 270 280 290 >>XP_011537797 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr (291 aa) initn: 2010 init1: 2010 opt: 2010 Z-score: 2093.4 bits: 395.3 E(85289): 7.3e-110 Smith-Waterman score: 2010; 100.0% identity (100.0% similar) in 291 aa overlap (1-291:1-291) 10 20 30 40 50 60 pF1KB4 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 PAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 RCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 AEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQN 190 200 210 220 230 240 250 260 270 280 290 pF1KB4 CPETSKKNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CPETSKKNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV 250 260 270 280 290 >>NP_001002266 (OMIM: 613335) E3 ubiquitin-protein ligas (291 aa) initn: 2010 init1: 2010 opt: 2010 Z-score: 2093.4 bits: 395.3 E(85289): 7.3e-110 Smith-Waterman score: 2010; 100.0% identity (100.0% similar) in 291 aa overlap (1-291:1-291) 10 20 30 40 50 60 pF1KB4 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 PAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 RCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 AEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQN 190 200 210 220 230 240 250 260 270 280 290 pF1KB4 CPETSKKNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CPETSKKNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV 250 260 270 280 290 >>XP_011537794 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr (573 aa) initn: 1526 init1: 1526 opt: 1536 Z-score: 1597.4 bits: 304.5 E(85289): 3.1e-82 Smith-Waterman score: 1536; 92.9% identity (94.5% similar) in 238 aa overlap (54-291:343-573) 30 40 50 60 70 80 pF1KB4 SKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASAPAPVSSFSRTSITPSSQDICRIC :: : . : :.: : .: :.:::: XP_011 FEDSTSAKLKSRVLRAPLCSTEKDSDLDCPSPFSEKLP-PISPVS------TSGDVCRIC 320 330 340 350 360 90 100 110 120 130 140 pF1KB4 HCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWE 370 380 390 400 410 420 150 160 170 180 190 200 pF1KB4 KLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVV 430 440 450 460 470 480 210 220 230 240 250 260 pF1KB4 VAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENK 490 500 510 520 530 540 270 280 290 pF1KB4 HGYGICHSDTNSSCCTEPEDTGAEIIHV :::::::::::::::::::::::::::: XP_011 HGYGICHSDTNSSCCTEPEDTGAEIIHV 550 560 570 >-- initn: 547 init1: 515 opt: 527 Z-score: 550.8 bits: 110.8 E(85289): 6.1e-24 Smith-Waterman score: 527; 78.4% identity (86.5% similar) in 111 aa overlap (1-103:1-110) 10 20 30 40 50 60 pF1KB4 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 PAPVSSFSRTSITPSSQDIC-------RICHCEGDDESPLITPC-HCTGSLHFVHQACLQ :::::::::::::::::::: . :: ... .: ... :: .:: XP_011 PAPVSSFSRTSITPSSQDICSSSAVFSECCH-HSSVQSAVVSKAPHCQSSLTQGLTVTVI 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 QWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWS XP_011 CKDTLQASKRNSFGSEWAQALKPAKNTKARRTLKFSRSLNDVGEKAQDTSESFAYVERTC 120 130 140 150 160 170 >>XP_011537795 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr (573 aa) initn: 1526 init1: 1526 opt: 1536 Z-score: 1597.4 bits: 304.5 E(85289): 3.1e-82 Smith-Waterman score: 1536; 92.9% identity (94.5% similar) in 238 aa overlap (54-291:343-573) 30 40 50 60 70 80 pF1KB4 SKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASAPAPVSSFSRTSITPSSQDICRIC :: : . : :.: : .: :.:::: XP_011 FEDSTSAKLKSRVLRAPLCSTEKDSDLDCPSPFSEKLP-PISPVS------TSGDVCRIC 320 330 340 350 360 90 100 110 120 130 140 pF1KB4 HCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWE 370 380 390 400 410 420 150 160 170 180 190 200 pF1KB4 KLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVV 430 440 450 460 470 480 210 220 230 240 250 260 pF1KB4 VAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENK 490 500 510 520 530 540 270 280 290 pF1KB4 HGYGICHSDTNSSCCTEPEDTGAEIIHV :::::::::::::::::::::::::::: XP_011 HGYGICHSDTNSSCCTEPEDTGAEIIHV 550 560 570 >-- initn: 547 init1: 515 opt: 527 Z-score: 550.8 bits: 110.8 E(85289): 6.1e-24 Smith-Waterman score: 527; 78.4% identity (86.5% similar) in 111 aa overlap (1-103:1-110) 10 20 30 40 50 60 pF1KB4 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 PAPVSSFSRTSITPSSQDIC-------RICHCEGDDESPLITPC-HCTGSLHFVHQACLQ :::::::::::::::::::: . :: ... .: ... :: .:: XP_011 PAPVSSFSRTSITPSSQDICSSSAVFSECCH-HSSVQSAVVSKAPHCQSSLTQGLTVTVI 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 QWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWS XP_011 CKDTLQASKRNSFGSEWAQALKPAKNTKARRTLKFSRSLNDVGEKAQDTSESFAYVERTC 120 130 140 150 160 170 >>XP_011537796 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr (573 aa) initn: 1526 init1: 1526 opt: 1536 Z-score: 1597.4 bits: 304.5 E(85289): 3.1e-82 Smith-Waterman score: 1536; 92.9% identity (94.5% similar) in 238 aa overlap (54-291:343-573) 30 40 50 60 70 80 pF1KB4 SKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASAPAPVSSFSRTSITPSSQDICRIC :: : . : :.: : .: :.:::: XP_011 FEDSTSAKLKSRVLRAPLCSTEKDSDLDCPSPFSEKLP-PISPVS------TSGDVCRIC 320 330 340 350 360 90 100 110 120 130 140 pF1KB4 HCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWE 370 380 390 400 410 420 150 160 170 180 190 200 pF1KB4 KLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVV 430 440 450 460 470 480 210 220 230 240 250 260 pF1KB4 VAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENK 490 500 510 520 530 540 270 280 290 pF1KB4 HGYGICHSDTNSSCCTEPEDTGAEIIHV :::::::::::::::::::::::::::: XP_011 HGYGICHSDTNSSCCTEPEDTGAEIIHV 550 560 570 >-- initn: 547 init1: 515 opt: 527 Z-score: 550.8 bits: 110.8 E(85289): 6.1e-24 Smith-Waterman score: 527; 78.4% identity (86.5% similar) in 111 aa overlap (1-103:1-110) 10 20 30 40 50 60 pF1KB4 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 PAPVSSFSRTSITPSSQDIC-------RICHCEGDDESPLITPC-HCTGSLHFVHQACLQ :::::::::::::::::::: . :: ... .: ... :: .:: XP_011 PAPVSSFSRTSITPSSQDICSSSAVFSECCH-HSSVQSAVVSKAPHCQSSLTQGLTVTVI 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 QWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWS XP_011 CKDTLQASKRNSFGSEWAQALKPAKNTKARRTLKFSRSLNDVGEKAQDTSESFAYVERTC 120 130 140 150 160 170 >>NP_001269795 (OMIM: 613335) E3 ubiquitin-protein ligas (573 aa) initn: 1526 init1: 1526 opt: 1536 Z-score: 1597.4 bits: 304.5 E(85289): 3.1e-82 Smith-Waterman score: 1536; 92.9% identity (94.5% similar) in 238 aa overlap (54-291:343-573) 30 40 50 60 70 80 pF1KB4 SKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASAPAPVSSFSRTSITPSSQDICRIC :: : . : :.: : .: :.:::: NP_001 FEDSTSAKLKSRVLRAPLCSTEKDSDLDCPSPFSEKLP-PISPVS------TSGDVCRIC 320 330 340 350 360 90 100 110 120 130 140 pF1KB4 HCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWE 370 380 390 400 410 420 150 160 170 180 190 200 pF1KB4 KLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVV 430 440 450 460 470 480 210 220 230 240 250 260 pF1KB4 VAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENK 490 500 510 520 530 540 270 280 290 pF1KB4 HGYGICHSDTNSSCCTEPEDTGAEIIHV :::::::::::::::::::::::::::: NP_001 HGYGICHSDTNSSCCTEPEDTGAEIIHV 550 560 570 >-- initn: 547 init1: 515 opt: 527 Z-score: 550.8 bits: 110.8 E(85289): 6.1e-24 Smith-Waterman score: 527; 78.4% identity (86.5% similar) in 111 aa overlap (1-103:1-110) 10 20 30 40 50 60 pF1KB4 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 PAPVSSFSRTSITPSSQDIC-------RICHCEGDDESPLITPC-HCTGSLHFVHQACLQ :::::::::::::::::::: . :: ... .: ... :: .:: NP_001 PAPVSSFSRTSITPSSQDICSSSAVFSECCH-HSSVQSAVVSKAPHCQSSLTQGLTVTVI 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 QWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWS NP_001 CKDTLQASKRNSFGSEWAQALKPAKNTKARRTLKFSRSLNDVGEKAQDTSESFAYVERTC 120 130 140 150 160 170 >>XP_005271861 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr (573 aa) initn: 1526 init1: 1526 opt: 1536 Z-score: 1597.4 bits: 304.5 E(85289): 3.1e-82 Smith-Waterman score: 1536; 92.9% identity (94.5% similar) in 238 aa overlap (54-291:343-573) 30 40 50 60 70 80 pF1KB4 SKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASAPAPVSSFSRTSITPSSQDICRIC :: : . : :.: : .: :.:::: XP_005 FEDSTSAKLKSRVLRAPLCSTEKDSDLDCPSPFSEKLP-PISPVS------TSGDVCRIC 320 330 340 350 360 90 100 110 120 130 140 pF1KB4 HCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWE 370 380 390 400 410 420 150 160 170 180 190 200 pF1KB4 KLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVV 430 440 450 460 470 480 210 220 230 240 250 260 pF1KB4 VAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENK 490 500 510 520 530 540 270 280 290 pF1KB4 HGYGICHSDTNSSCCTEPEDTGAEIIHV :::::::::::::::::::::::::::: XP_005 HGYGICHSDTNSSCCTEPEDTGAEIIHV 550 560 570 >-- initn: 547 init1: 515 opt: 527 Z-score: 550.8 bits: 110.8 E(85289): 6.1e-24 Smith-Waterman score: 527; 78.4% identity (86.5% similar) in 111 aa overlap (1-103:1-110) 10 20 30 40 50 60 pF1KB4 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 PAPVSSFSRTSITPSSQDIC-------RICHCEGDDESPLITPC-HCTGSLHFVHQACLQ :::::::::::::::::::: . :: ... .: ... :: .:: XP_005 PAPVSSFSRTSITPSSQDICSSSAVFSECCH-HSSVQSAVVSKAPHCQSSLTQGLTVTVI 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 QWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWS XP_005 CKDTLQASKRNSFGSEWAQALKPAKNTKARRTLKFSRSLNDVGEKAQDTSESFAYVERTC 120 130 140 150 160 170 >>XP_006717767 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr (573 aa) initn: 1526 init1: 1526 opt: 1536 Z-score: 1597.4 bits: 304.5 E(85289): 3.1e-82 Smith-Waterman score: 1536; 92.9% identity (94.5% similar) in 238 aa overlap (54-291:343-573) 30 40 50 60 70 80 pF1KB4 SKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASAPAPVSSFSRTSITPSSQDICRIC :: : . : :.: : .: :.:::: XP_006 FEDSTSAKLKSRVLRAPLCSTEKDSDLDCPSPFSEKLP-PISPVS------TSGDVCRIC 320 330 340 350 360 90 100 110 120 130 140 pF1KB4 HCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWE 370 380 390 400 410 420 150 160 170 180 190 200 pF1KB4 KLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVV 430 440 450 460 470 480 210 220 230 240 250 260 pF1KB4 VAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENK 490 500 510 520 530 540 270 280 290 pF1KB4 HGYGICHSDTNSSCCTEPEDTGAEIIHV :::::::::::::::::::::::::::: XP_006 HGYGICHSDTNSSCCTEPEDTGAEIIHV 550 560 570 >-- initn: 547 init1: 515 opt: 527 Z-score: 550.8 bits: 110.8 E(85289): 6.1e-24 Smith-Waterman score: 527; 78.4% identity (86.5% similar) in 111 aa overlap (1-103:1-110) 10 20 30 40 50 60 pF1KB4 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASA 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 PAPVSSFSRTSITPSSQDIC-------RICHCEGDDESPLITPC-HCTGSLHFVHQACLQ :::::::::::::::::::: . :: ... .: ... :: .:: XP_006 PAPVSSFSRTSITPSSQDICSSSAVFSECCH-HSSVQSAVVSKAPHCQSSLTQGLTVTVI 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 QWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWS XP_006 CKDTLQASKRNSFGSEWAQALKPAKNTKARRTLKFSRSLNDVGEKAQDTSESFAYVERTC 120 130 140 150 160 170 291 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 06:02:54 2016 done: Sat Nov 5 06:02:55 2016 Total Scan time: 4.900 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]