FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4846, 480 aa 1>>>pF1KB4846 480 - 480 aa - 480 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.8285+/-0.000362; mu= -2.2299+/- 0.022 mean_var=251.6268+/-52.944, 0's: 0 Z-trim(121.3): 41 B-trim: 288 in 1/53 Lambda= 0.080853 statistics sampled from 37794 (37835) to 37794 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.761), E-opt: 0.2 (0.444), width: 16 Scan time: 8.450 The best scores are: opt bits E(85289) NP_001745 (OMIM: 151385,601399) runt-related trans ( 480) 3253 392.5 1.4e-108 XP_011528068 (OMIM: 151385,601399) PREDICTED: runt ( 480) 3253 392.5 1.4e-108 XP_011528069 (OMIM: 151385,601399) PREDICTED: runt ( 467) 3022 365.5 1.8e-100 NP_001001890 (OMIM: 151385,601399) runt-related tr ( 453) 3020 365.3 2.1e-100 XP_005261125 (OMIM: 151385,601399) PREDICTED: runt ( 468) 3020 365.3 2.1e-100 XP_016883976 (OMIM: 151385,601399) PREDICTED: runt ( 429) 2896 350.8 4.5e-96 NP_001265407 (OMIM: 119600,156510,600211) runt-rel ( 485) 1913 236.1 1.6e-61 NP_001015051 (OMIM: 119600,156510,600211) runt-rel ( 499) 1913 236.2 1.7e-61 XP_011513264 (OMIM: 119600,156510,600211) PREDICTE ( 567) 1913 236.2 1.8e-61 XP_011528072 (OMIM: 151385,601399) PREDICTED: runt ( 277) 1810 224.0 4.3e-58 NP_001116079 (OMIM: 151385,601399) runt-related tr ( 250) 1577 196.8 6e-50 XP_011528070 (OMIM: 151385,601399) PREDICTED: runt ( 403) 1451 182.2 2.3e-45 XP_005261126 (OMIM: 151385,601399) PREDICTED: runt ( 416) 1451 182.2 2.4e-45 XP_016866881 (OMIM: 119600,156510,600211) PREDICTE ( 528) 1242 157.9 6.3e-38 XP_016866880 (OMIM: 119600,156510,600211) PREDICTE ( 592) 1242 157.9 6.9e-38 XP_011513262 (OMIM: 119600,156510,600211) PREDICTE ( 610) 1242 157.9 7.1e-38 NP_001019801 (OMIM: 119600,156510,600211) runt-rel ( 521) 1232 156.7 1.4e-37 XP_011513263 (OMIM: 119600,156510,600211) PREDICTE ( 589) 1232 156.8 1.5e-37 XP_011513266 (OMIM: 119600,156510,600211) PREDICTE ( 508) 1223 155.7 2.8e-37 XP_016866882 (OMIM: 119600,156510,600211) PREDICTE ( 438) 1208 153.9 8.5e-37 XP_011513267 (OMIM: 119600,156510,600211) PREDICTE ( 416) 1199 152.8 1.7e-36 NP_001026850 (OMIM: 600210) runt-related transcrip ( 429) 1087 139.8 1.5e-32 XP_005246081 (OMIM: 600210) PREDICTED: runt-relate ( 429) 1087 139.8 1.5e-32 NP_001307601 (OMIM: 600210) runt-related transcrip ( 429) 1087 139.8 1.5e-32 NP_004341 (OMIM: 600210) runt-related transcriptio ( 415) 1083 139.3 2e-32 XP_011540653 (OMIM: 600210) PREDICTED: runt-relate ( 376) 938 122.3 2.3e-27 XP_011513265 (OMIM: 119600,156510,600211) PREDICTE ( 552) 873 114.9 5.9e-25 XP_006715295 (OMIM: 119600,156510,600211) PREDICTE ( 449) 870 114.5 6.4e-25 XP_011513268 (OMIM: 119600,156510,600211) PREDICTE ( 386) 865 113.8 8.5e-25 XP_016866885 (OMIM: 119600,156510,600211) PREDICTE ( 276) 856 112.7 1.4e-24 XP_016866883 (OMIM: 119600,156510,600211) PREDICTE ( 358) 856 112.8 1.7e-24 XP_016866884 (OMIM: 119600,156510,600211) PREDICTE ( 338) 840 110.9 5.8e-24 XP_016858159 (OMIM: 600210) PREDICTED: runt-relate ( 162) 693 93.5 4.7e-19 >>NP_001745 (OMIM: 151385,601399) runt-related transcrip (480 aa) initn: 3253 init1: 3253 opt: 3253 Z-score: 2070.2 bits: 392.5 E(85289): 1.4e-108 Smith-Waterman score: 3253; 99.8% identity (99.8% similar) in 480 aa overlap (1-480:1-480) 10 20 30 40 50 60 pF1KB4 MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEASPLGA ::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::: NP_001 MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 PDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 LGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 TNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 HHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 PISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 TSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 GERSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GERSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY 430 440 450 460 470 480 >>XP_011528068 (OMIM: 151385,601399) PREDICTED: runt-rel (480 aa) initn: 3253 init1: 3253 opt: 3253 Z-score: 2070.2 bits: 392.5 E(85289): 1.4e-108 Smith-Waterman score: 3253; 99.8% identity (99.8% similar) in 480 aa overlap (1-480:1-480) 10 20 30 40 50 60 pF1KB4 MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEASPLGA ::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::: XP_011 MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 PDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 LGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 TNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 HHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 PISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 TSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 GERSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GERSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY 430 440 450 460 470 480 >>XP_011528069 (OMIM: 151385,601399) PREDICTED: runt-rel (467 aa) initn: 3021 init1: 3021 opt: 3022 Z-score: 1924.8 bits: 365.5 E(85289): 1.8e-100 Smith-Waterman score: 3121; 97.1% identity (97.1% similar) in 480 aa overlap (1-480:1-467) 10 20 30 40 50 60 pF1KB4 MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEASPLGA ::::::::::::::::::: ::::::::::::::::::::::: :::: XP_011 MASDSIFESFPSYPQCFMR-------------DASTSRRFTPPSTALSPGKMSEALPLGA 10 20 30 40 70 80 90 100 110 120 pF1KB4 PDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVA 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB4 LGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVF 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB4 TNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSP 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB4 HHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPAT 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB4 PISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPV 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB4 TSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVG 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB4 GERSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GERSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY 410 420 430 440 450 460 >>NP_001001890 (OMIM: 151385,601399) runt-related transc (453 aa) initn: 3020 init1: 3020 opt: 3020 Z-score: 1923.7 bits: 365.3 E(85289): 2.1e-100 Smith-Waterman score: 3020; 99.8% identity (99.8% similar) in 448 aa overlap (33-480:6-453) 10 20 30 40 50 60 pF1KB4 SDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEASPLGAPD ::::::::::::::::::::::: :::::: NP_001 MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPD 10 20 30 70 80 90 100 110 120 pF1KB4 AGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALG 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB4 DVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTN 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB4 PPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHH 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB4 PAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPI 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB4 SPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTS 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB4 GIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGE 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB4 RSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY 400 410 420 430 440 450 >>XP_005261125 (OMIM: 151385,601399) PREDICTED: runt-rel (468 aa) initn: 3020 init1: 3020 opt: 3020 Z-score: 1923.5 bits: 365.3 E(85289): 2.1e-100 Smith-Waterman score: 3020; 99.8% identity (99.8% similar) in 448 aa overlap (33-480:21-468) 10 20 30 40 50 60 pF1KB4 SDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEASPLGAPD ::::::::::::::::::::::: :::::: XP_005 MPAAPRGPAQGEAAARTRSRDASTSRRFTPPSTALSPGKMSEALPLGAPD 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 AGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB4 DVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTN 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB4 PPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHH 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB4 PAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPI 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB4 SPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTS 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB4 GIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGE 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB4 RSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY 420 430 440 450 460 >>XP_016883976 (OMIM: 151385,601399) PREDICTED: runt-rel (429 aa) initn: 2896 init1: 2896 opt: 2896 Z-score: 1845.8 bits: 350.8 E(85289): 4.5e-96 Smith-Waterman score: 2896; 99.8% identity (99.8% similar) in 429 aa overlap (52-480:1-429) 30 40 50 60 70 80 pF1KB4 ILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEASPLGAPDAGAALAGKLRSGDRSMVEV :::: ::::::::::::::::::::::::: XP_016 MSEALPLGAPDAGAALAGKLRSGDRSMVEV 10 20 30 90 100 110 120 130 140 pF1KB4 LADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYS 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB4 AELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPR 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB4 EPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNP 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB4 QPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRL 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB4 STAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYL 280 290 300 310 320 330 390 400 410 420 430 440 pF1KB4 PPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSAL 340 350 360 370 380 390 450 460 470 480 pF1KB4 LNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY ::::::::::::::::::::::::::::::::::::::: XP_016 LNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY 400 410 420 >>NP_001265407 (OMIM: 119600,156510,600211) runt-related (485 aa) initn: 1554 init1: 880 opt: 1913 Z-score: 1225.4 bits: 236.1 E(85289): 1.6e-61 Smith-Waterman score: 1963; 62.9% identity (80.3% similar) in 493 aa overlap (33-480:6-485) 10 20 30 40 50 pF1KB4 SDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEASPL---- : ::::::.:::..:.:::::..::. NP_001 MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQ 10 20 30 60 70 80 pF1KB4 -------------------------------GAPDAGAALAGKLRS--GDRSMVEVLADH .: :.:: . .:: .:.:::..::: NP_001 QQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADH 40 50 60 70 80 90 90 100 110 120 130 140 pF1KB4 PGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELR :.::::::::::::::::.:::::::::.::::::::.:::::.:::::::::::::::: NP_001 PAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELR 100 110 120 130 140 150 150 160 170 180 190 200 pF1KB4 NATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRR ::.:.::::::::::::::::::::::::::::::::::::::::::::.:::::::::: NP_001 NASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRR 160 170 180 190 200 210 210 220 230 240 250 260 pF1KB4 HRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHS-TAFNPQPQ ::::::: .:: :: ::.:::.: .. . .:::. .: ::: ::: . . :::: : NP_001 HRQKLDD-SKP-SL-FSDRLSDLGRIPHPSMRVG----VPPQNPRPSLNSAPSPFNPQGQ 220 230 240 250 260 270 280 290 300 310 320 pF1KB4 SQMQDTRQIQPSPPWSYDQSY-QYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLST ::. : :: : :::::::::: .::....:::.: .::.: :..:. ... .. :.: NP_001 SQITDPRQAQSSPPWSYDQSYPSYLSQMTSPSIHSTTPLSSTRGTGLPAIT-DVPRRISG 270 280 290 300 310 320 330 340 350 360 370 pF1KB4 APDLTAFSDPRQFPALPSI-----SDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYH : .: ::::::::.. :. :.::::::..:::.: :::::...:::: .:.:: NP_001 ASELGPFSDPRQFPSISSLTESRFSNPRMHYPATFTYTP-PVTSGMSLGMSA---TTHYH 330 340 350 360 370 380 380 390 400 410 420 430 pF1KB4 TYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMV-GGERSPPRILPPCTNAST ::::::::::::.:.::::.:: : ::::.:.::::: :: ::.::: :.:::::..:. NP_001 TYLPPPYPGSSQSQSGPFQTSSTPY-LYYGTSSGSYQFPMVPGGDRSPSRMLPPCTTTSN 390 400 410 420 430 440 440 450 460 470 480 pF1KB4 GSALLNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY ::.::::.::::.: :.:.::::.::: . :.:..:.::::: NP_001 GSTLLNPNLPNQNDGVDADGSHSSSPTVLNSSGRMDESVWRPY 450 460 470 480 >>NP_001015051 (OMIM: 119600,156510,600211) runt-related (499 aa) initn: 1554 init1: 880 opt: 1913 Z-score: 1225.2 bits: 236.2 E(85289): 1.7e-61 Smith-Waterman score: 1965; 60.4% identity (77.5% similar) in 525 aa overlap (1-480:1-499) 10 20 30 40 50 pF1KB4 MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEASPL-- :::.:.: . : :. : ::::::.:::..:.:::::..::. NP_001 MASNSLFSTVTPCQQNFFW-------------DPSTSRRFSPPSSSLQPGKMSDVSPVVA 10 20 30 40 60 70 80 pF1KB4 ---------------------------------GAPDAGAALAGKLRS--GDRSMVEVLA .: :.:: . .:: .:.:::..: NP_001 AQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIA 50 60 70 80 90 100 90 100 110 120 130 140 pF1KB4 DHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAE :::.::::::::::::::::.:::::::::.::::::::.:::::.:::::::::::::: NP_001 DHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAE 110 120 130 140 150 160 150 160 170 180 190 200 pF1KB4 LRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREP ::::.:.::::::::::::::::::::::::::::::::::::::::::::.:::::::: NP_001 LRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREP 170 180 190 200 210 220 210 220 230 240 250 260 pF1KB4 RRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHS-TAFNPQ ::::::::: .:: :: ::.:::.: .. . .:::. .: ::: ::: . . :::: NP_001 RRHRQKLDD-SKP-SL-FSDRLSDLGRIPHPSMRVG----VPPQNPRPSLNSAPSPFNPQ 230 240 250 260 270 280 270 280 290 300 310 320 pF1KB4 PQSQMQDTRQIQPSPPWSYDQSY-QYLGSIASPSVHPATPISPGRASGMTTLSAELSSRL :::. : :: : :::::::::: .::....:::.: .::.: :..:. ... .. :. NP_001 GQSQITDPRQAQSSPPWSYDQSYPSYLSQMTSPSIHSTTPLSSTRGTGLPAIT-DVPRRI 290 300 310 320 330 330 340 350 360 370 pF1KB4 STAPDLTAFSDPRQFPALPSI-----SDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATR : : .: ::::::::.. :. :.::::::..:::.: :::::...:::: .:. NP_001 SGASELGPFSDPRQFPSISSLTESRFSNPRMHYPATFTYTP-PVTSGMSLGMSA---TTH 340 350 360 370 380 390 380 390 400 410 420 430 pF1KB4 YHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMV-GGERSPPRILPPCTNA ::::::::::::::.:.::::.:: : ::::.:.::::: :: ::.::: :.:::::.. NP_001 YHTYLPPPYPGSSQSQSGPFQTSSTPY-LYYGTSSGSYQFPMVPGGDRSPSRMLPPCTTT 400 410 420 430 440 450 440 450 460 470 480 pF1KB4 STGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY :.::.::::.::::.: :.:.::::.::: . :.:..:.::::: NP_001 SNGSTLLNPNLPNQNDGVDADGSHSSSPTVLNSSGRMDESVWRPY 460 470 480 490 >>XP_011513264 (OMIM: 119600,156510,600211) PREDICTED: r (567 aa) initn: 1554 init1: 880 opt: 1913 Z-score: 1224.4 bits: 236.2 E(85289): 1.8e-61 Smith-Waterman score: 1965; 60.4% identity (77.5% similar) in 525 aa overlap (1-480:69-567) 10 20 30 pF1KB4 MASDSIFESFPSYPQCFMRECILGMNPSRD :::.:.: . : :. XP_011 QPPRPTESFKAASSIYNRGYKFYLKKKGGTMASNSLFSTVTPCQQNFFW----------- 40 50 60 70 80 40 50 pF1KB4 VHDASTSRRFTPPSTALSPGKMSEASPL-------------------------------- : ::::::.:::..:.:::::..::. XP_011 --DPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAA 90 100 110 120 130 140 60 70 80 90 100 110 pF1KB4 ---GAPDAGAALAGKLRS--GDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLP .: :.:: . .:: .:.:::..::::.::::::::::::::::.::::::::: XP_011 AAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLP 150 160 170 180 190 200 120 130 140 150 160 170 pF1KB4 IAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSF .::::::::.:::::.::::::::::::::::::.:.::::::::::::::::::::::: XP_011 VAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSF 210 220 230 240 250 260 180 190 200 210 220 230 pF1KB4 TLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRR :::::::::::::::::::::.::::::::::::::::: .:: :: ::.:::.: .. . XP_011 TLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLDD-SKP-SL-FSDRLSDLGRIPH 270 280 290 300 310 320 240 250 260 270 280 290 pF1KB4 TAMRVSPHHPAPTPNPRASLNHS-TAFNPQPQSQMQDTRQIQPSPPWSYDQSY-QYLGSI .:::. .: ::: ::: . . :::: :::. : :: : :::::::::: .::... XP_011 PSMRVG----VPPQNPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSYLSQM 330 340 350 360 370 300 310 320 330 340 pF1KB4 ASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSI-----SDPR .:::.: .::.: :..:. ... .. :.: : .: ::::::::.. :. :.:: XP_011 TSPSIHSTTPLSSTRGTGLPAIT-DVPRRISGASELGPFSDPRQFPSISSLTESRFSNPR 380 390 400 410 420 430 350 360 370 380 390 400 pF1KB4 MHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLY ::::..:::.: :::::...:::: .:.::::::::::::::.:.::::.:: : :: XP_011 MHYPATFTYTP-PVTSGMSLGMSA---TTHYHTYLPPPYPGSSQSQSGPFQTSSTPY-LY 440 450 460 470 480 490 410 420 430 440 450 460 pF1KB4 YGASAGSYQFSMV-GGERSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTN ::.:.::::: :: ::.::: :.:::::..:.::.::::.::::.: :.:.::::.::: XP_011 YGTSSGSYQFPMVPGGDRSPSRMLPPCTTTSNGSTLLNPNLPNQNDGVDADGSHSSSPTV 500 510 520 530 540 550 470 480 pF1KB4 MAPSARLEEAVWRPY . :.:..:.::::: XP_011 LNSSGRMDESVWRPY 560 >>XP_011528072 (OMIM: 151385,601399) PREDICTED: runt-rel (277 aa) initn: 1801 init1: 1801 opt: 1810 Z-score: 1163.9 bits: 224.0 E(85289): 4.3e-58 Smith-Waterman score: 1810; 96.4% identity (97.5% similar) in 279 aa overlap (1-279:1-275) 10 20 30 40 50 60 pF1KB4 MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEASPLGA ::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::: XP_011 MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 PDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 LGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 TNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 HHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPAT ::::::::::::::::::::::::::::. . . :: XP_011 HHPAPTPNPRASLNHSTAFNPQPQSQMQE----EDTAPWRC 250 260 270 310 320 330 340 350 360 pF1KB4 PISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPV 480 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 21:46:48 2016 done: Thu Nov 3 21:46:49 2016 Total Scan time: 8.450 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]