FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4929, 198 aa 1>>>pF1KB4929 198 - 198 aa - 198 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6037+/-0.000435; mu= 17.5934+/- 0.027 mean_var=75.5560+/-15.633, 0's: 0 Z-trim(112.7): 167 B-trim: 1396 in 2/47 Lambda= 0.147550 statistics sampled from 21558 (21783) to 21558 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.638), E-opt: 0.2 (0.255), width: 16 Scan time: 5.620 The best scores are: opt bits E(85289) NP_057187 (OMIM: 246700,607690) GTP-binding protei ( 198) 1312 288.4 5e-78 NP_001028675 (OMIM: 246700,607690) GTP-binding pro ( 198) 1312 288.4 5e-78 XP_016865010 (OMIM: 246700,607690) PREDICTED: GTP- ( 198) 1312 288.4 5e-78 NP_064535 (OMIM: 607691) GTP-binding protein SAR1a ( 198) 1215 267.8 8.3e-72 NP_001136120 (OMIM: 607691) GTP-binding protein SA ( 198) 1215 267.8 8.3e-72 NP_001654 (OMIM: 600464) ADP-ribosylation factor 6 ( 175) 320 77.2 1.7e-14 NP_001658 (OMIM: 601175) ADP-ribosylation factor-l ( 184) 313 75.7 5e-14 NP_001649 (OMIM: 103180) ADP-ribosylation factor 1 ( 181) 311 75.3 6.6e-14 NP_001019398 (OMIM: 103180) ADP-ribosylation facto ( 181) 311 75.3 6.6e-14 NP_001019399 (OMIM: 103180) ADP-ribosylation facto ( 181) 311 75.3 6.6e-14 NP_001019397 (OMIM: 103180) ADP-ribosylation facto ( 181) 311 75.3 6.6e-14 XP_005268913 (OMIM: 103190) PREDICTED: ADP-ribosyl ( 181) 307 74.4 1.2e-13 NP_001650 (OMIM: 103190) ADP-ribosylation factor 3 ( 181) 307 74.4 1.2e-13 NP_079323 (OMIM: 614439) ADP-ribosylation factor-l ( 192) 307 74.5 1.2e-13 NP_612459 (OMIM: 609351) ADP-ribosylation factor-l ( 196) 306 74.3 1.5e-13 XP_005266310 (OMIM: 609351) PREDICTED: ADP-ribosyl ( 196) 306 74.3 1.5e-13 XP_016864933 (OMIM: 601747) PREDICTED: E3 ubiquiti ( 569) 306 74.8 3e-13 NP_150230 (OMIM: 601747) E3 ubiquitin-protein liga ( 569) 306 74.8 3e-13 NP_001310443 (OMIM: 209900,268000,600151,608845,61 ( 159) 298 72.5 4.1e-13 XP_016862801 (OMIM: 209900,268000,600151,608845,61 ( 159) 298 72.5 4.1e-13 NP_001653 (OMIM: 103188) ADP-ribosylation factor 5 ( 180) 298 72.5 4.5e-13 NP_816931 (OMIM: 209900,268000,600151,608845,61357 ( 186) 298 72.5 4.6e-13 NP_115522 (OMIM: 209900,268000,600151,608845,61357 ( 186) 298 72.5 4.6e-13 NP_001265222 (OMIM: 209900,268000,600151,608845,61 ( 186) 298 72.5 4.6e-13 XP_016862800 (OMIM: 209900,268000,600151,608845,61 ( 186) 298 72.5 4.6e-13 NP_001310442 (OMIM: 209900,268000,600151,608845,61 ( 193) 298 72.6 4.7e-13 NP_001652 (OMIM: 600732) ADP-ribosylation factor-l ( 201) 296 72.1 6.5e-13 XP_011523084 (OMIM: 600732) PREDICTED: ADP-ribosyl ( 201) 296 72.1 6.5e-13 NP_150231 (OMIM: 601747) E3 ubiquitin-protein liga ( 546) 300 73.5 7.1e-13 NP_060654 (OMIM: 616596) ADP-ribosylation factor-l ( 186) 294 71.7 8.3e-13 XP_005248554 (OMIM: 601747) PREDICTED: E3 ubiquiti ( 398) 297 72.7 8.9e-13 NP_001647 (OMIM: 601747) E3 ubiquitin-protein liga ( 574) 297 72.8 1.1e-12 NP_001651 (OMIM: 601177) ADP-ribosylation factor 4 ( 180) 284 69.5 3.5e-12 NP_620150 (OMIM: 616597) ADP-ribosylation factor-l ( 186) 283 69.3 4.2e-12 XP_016871749 (OMIM: 604695) PREDICTED: ADP-ribosyl ( 182) 276 67.8 1.2e-11 NP_004302 (OMIM: 604695) ADP-ribosylation factor-l ( 182) 276 67.8 1.2e-11 XP_016856722 (OMIM: 103180) PREDICTED: ADP-ribosyl ( 212) 276 67.9 1.3e-11 XP_006719454 (OMIM: 103190) PREDICTED: ADP-ribosyl ( 137) 273 67.1 1.5e-11 NP_001167621 (OMIM: 608922,612291) ADP-ribosylatio ( 428) 278 68.7 1.5e-11 NP_878899 (OMIM: 608922,612291) ADP-ribosylation f ( 428) 278 68.7 1.5e-11 XP_011510837 (OMIM: 608922,612291) PREDICTED: ADP- ( 403) 272 67.4 3.6e-11 NP_001168 (OMIM: 603425) ADP-ribosylation factor-l ( 181) 266 65.7 5e-11 NP_001032241 (OMIM: 604786) ADP-ribosylation facto ( 200) 261 64.7 1.1e-10 NP_005729 (OMIM: 604786) ADP-ribosylation factor-l ( 200) 261 64.7 1.1e-10 NP_997625 (OMIM: 604786) ADP-ribosylation factor-l ( 200) 261 64.7 1.1e-10 NP_001182325 (OMIM: 604786) ADP-ribosylation facto ( 200) 261 64.7 1.1e-10 NP_005728 (OMIM: 604787) ADP-ribosylation factor-l ( 192) 258 64.0 1.7e-10 NP_001269360 (OMIM: 604787) ADP-ribosylation facto ( 201) 258 64.1 1.8e-10 NP_036229 (OMIM: 608960) ADP-ribosylation factor-l ( 179) 250 62.3 5.3e-10 NP_848930 (OMIM: 608909) ADP-ribosylation factor-l ( 179) 248 61.9 7.1e-10 >>NP_057187 (OMIM: 246700,607690) GTP-binding protein SA (198 aa) initn: 1312 init1: 1312 opt: 1312 Z-score: 1521.8 bits: 288.4 E(85289): 5e-78 Smith-Waterman score: 1312; 100.0% identity (100.0% similar) in 198 aa overlap (1-198:1-198) 10 20 30 40 50 60 pF1KB4 MSFIFDWIYSGFSSVLQFLGLYKKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MSFIFDWIYSGFSSVLQFLGLYKKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 SEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDSLMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDSLMT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 DETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSISLKELNARPLEVFMCSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 DETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSISLKELNARPLEVFMCSV 130 140 150 160 170 180 190 pF1KB4 LKRQGYGEGFRWMAQYID :::::::::::::::::: NP_057 LKRQGYGEGFRWMAQYID 190 >>NP_001028675 (OMIM: 246700,607690) GTP-binding protein (198 aa) initn: 1312 init1: 1312 opt: 1312 Z-score: 1521.8 bits: 288.4 E(85289): 5e-78 Smith-Waterman score: 1312; 100.0% identity (100.0% similar) in 198 aa overlap (1-198:1-198) 10 20 30 40 50 60 pF1KB4 MSFIFDWIYSGFSSVLQFLGLYKKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSFIFDWIYSGFSSVLQFLGLYKKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 SEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDSLMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDSLMT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 DETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSISLKELNARPLEVFMCSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSISLKELNARPLEVFMCSV 130 140 150 160 170 180 190 pF1KB4 LKRQGYGEGFRWMAQYID :::::::::::::::::: NP_001 LKRQGYGEGFRWMAQYID 190 >>XP_016865010 (OMIM: 246700,607690) PREDICTED: GTP-bind (198 aa) initn: 1312 init1: 1312 opt: 1312 Z-score: 1521.8 bits: 288.4 E(85289): 5e-78 Smith-Waterman score: 1312; 100.0% identity (100.0% similar) in 198 aa overlap (1-198:1-198) 10 20 30 40 50 60 pF1KB4 MSFIFDWIYSGFSSVLQFLGLYKKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSFIFDWIYSGFSSVLQFLGLYKKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 SEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDSLMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDSLMT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 DETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSISLKELNARPLEVFMCSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSISLKELNARPLEVFMCSV 130 140 150 160 170 180 190 pF1KB4 LKRQGYGEGFRWMAQYID :::::::::::::::::: XP_016 LKRQGYGEGFRWMAQYID 190 >>NP_064535 (OMIM: 607691) GTP-binding protein SAR1a [Ho (198 aa) initn: 1215 init1: 1215 opt: 1215 Z-score: 1410.2 bits: 267.8 E(85289): 8.3e-72 Smith-Waterman score: 1215; 89.9% identity (98.0% similar) in 198 aa overlap (1-198:1-198) 10 20 30 40 50 60 pF1KB4 MSFIFDWIYSGFSSVLQFLGLYKKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPT :::::.:::.::::::::::::::.::::::::::::::::::::::::::::::::::: NP_064 MSFIFEWIYNGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 SEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDSLMT ::::::::::::::::::: ::::::::::::::::::::::::: ::.::: ::..::: NP_064 SEELTIAGMTFTTFDLGGHEQARRVWKNYLPAINGIVFLVDCADHSRLVESKVELNALMT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 DETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSISLKELNARPLEVFMCSV ::::.::::::::::::: .:::::.:::.:::::::::::...::::::::.::::::: NP_064 DETISNVPILILGNKIDRTDAISEEKLREIFGLYGQTTGKGNVTLKELNARPMEVFMCSV 130 140 150 160 170 180 190 pF1KB4 LKRQGYGEGFRWMAQYID ::::::::::::..:::: NP_064 LKRQGYGEGFRWLSQYID 190 >>NP_001136120 (OMIM: 607691) GTP-binding protein SAR1a (198 aa) initn: 1215 init1: 1215 opt: 1215 Z-score: 1410.2 bits: 267.8 E(85289): 8.3e-72 Smith-Waterman score: 1215; 89.9% identity (98.0% similar) in 198 aa overlap (1-198:1-198) 10 20 30 40 50 60 pF1KB4 MSFIFDWIYSGFSSVLQFLGLYKKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPT :::::.:::.::::::::::::::.::::::::::::::::::::::::::::::::::: NP_001 MSFIFEWIYNGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 SEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDSLMT ::::::::::::::::::: ::::::::::::::::::::::::: ::.::: ::..::: NP_001 SEELTIAGMTFTTFDLGGHEQARRVWKNYLPAINGIVFLVDCADHSRLVESKVELNALMT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 DETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSISLKELNARPLEVFMCSV ::::.::::::::::::: .:::::.:::.:::::::::::...::::::::.::::::: NP_001 DETISNVPILILGNKIDRTDAISEEKLREIFGLYGQTTGKGNVTLKELNARPMEVFMCSV 130 140 150 160 170 180 190 pF1KB4 LKRQGYGEGFRWMAQYID ::::::::::::..:::: NP_001 LKRQGYGEGFRWLSQYID 190 >>NP_001654 (OMIM: 600464) ADP-ribosylation factor 6 [Ho (175 aa) initn: 318 init1: 318 opt: 320 Z-score: 381.2 bits: 77.2 E(85289): 1.7e-14 Smith-Waterman score: 320; 38.3% identity (74.4% similar) in 133 aa overlap (24-153:12-141) 10 20 30 40 50 pF1KB4 MSFIFDWIYSGFSSVLQFLGLYKKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHV---PTL : ....:::: :::::.:. :: ::: : ::. NP_001 MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLK---LGQSVTTIPTV 10 20 30 40 60 70 80 90 100 110 pF1KB4 HPTSEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDS . : .: .. :...:.::. . : .:..: . .:..:.:::::..:. :...:: NP_001 GFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHR 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB4 LMTDETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSISLKELNARPLEVFM ...:. . .. :::..:: : :.:.. ....: .:: NP_001 IINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEG 110 120 130 140 150 160 180 190 pF1KB4 CSVLKRQGYGEGFRWMAQYID NP_001 LTWLTSNYKS 170 >>NP_001658 (OMIM: 601175) ADP-ribosylation factor-like (184 aa) initn: 293 init1: 293 opt: 313 Z-score: 372.9 bits: 75.7 E(85289): 5e-14 Smith-Waterman score: 313; 34.3% identity (72.0% similar) in 143 aa overlap (11-153:2-144) 10 20 30 40 50 60 pF1KB4 MSFIFDWIYSGFSSVLQFLGLYKKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPT :. ..:. . .. .:..::::::::::.:. .. . . ::: . NP_001 MGLLTILKKMKQKERELRLLMLGLDNAGKTTILKKFNGEDIDTISPTLGFN 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 SEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDSLMT . : :. .. .:.::. . : :.::. . .:....:: ::..:. . ..::.::.. NP_001 IKTLEHRGFKLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSADRQRMQDCQRELQSLLV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB4 DETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSISLKELNARPLEVFMCSV .: .:.. .::..:: : : :.: . .::.. : NP_001 EERLAGATLLIFANKQDLPGALSSNAIREVLELDSIRSHHWCIQGCSAVTGENLLPGIDW 120 130 140 150 160 170 190 pF1KB4 LKRQGYGEGFRWMAQYID NP_001 LLDDISSRIFTAD 180 >>NP_001649 (OMIM: 103180) ADP-ribosylation factor 1 [Ho (181 aa) initn: 301 init1: 301 opt: 311 Z-score: 370.7 bits: 75.3 E(85289): 6.6e-14 Smith-Waterman score: 312; 29.8% identity (66.3% similar) in 181 aa overlap (18-197:9-177) 10 20 30 40 50 pF1KB4 MSFIFDWIYSGFSSVLQFLGLY-KKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHP : ::. :: .....::: :::::.:. :: .. .::. NP_001 MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGF 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 TSEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDSLM . : . ...::..:.::. . : .:..:. .:..:.:: :.::. :..::: .. NP_001 NVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRML 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 TDETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSISLKELNARPLEVFMCS ... . .. .:...:: : :.:.. .. . .::. ::.. : . :. NP_001 AEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLH---------SLRHRNWYIQAT--CA 120 130 140 150 160 180 190 pF1KB4 VLKRQGYGEGFRWMAQYID . . .: ::. :... . NP_001 T-SGDGLYEGLDWLSNQLRNQK 170 180 >>NP_001019398 (OMIM: 103180) ADP-ribosylation factor 1 (181 aa) initn: 301 init1: 301 opt: 311 Z-score: 370.7 bits: 75.3 E(85289): 6.6e-14 Smith-Waterman score: 312; 29.8% identity (66.3% similar) in 181 aa overlap (18-197:9-177) 10 20 30 40 50 pF1KB4 MSFIFDWIYSGFSSVLQFLGLY-KKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHP : ::. :: .....::: :::::.:. :: .. .::. NP_001 MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGF 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 TSEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDSLM . : . ...::..:.::. . : .:..:. .:..:.:: :.::. :..::: .. NP_001 NVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRML 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 TDETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSISLKELNARPLEVFMCS ... . .. .:...:: : :.:.. .. . .::. ::.. : . :. NP_001 AEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLH---------SLRHRNWYIQAT--CA 120 130 140 150 160 180 190 pF1KB4 VLKRQGYGEGFRWMAQYID . . .: ::. :... . NP_001 T-SGDGLYEGLDWLSNQLRNQK 170 180 >>NP_001019399 (OMIM: 103180) ADP-ribosylation factor 1 (181 aa) initn: 301 init1: 301 opt: 311 Z-score: 370.7 bits: 75.3 E(85289): 6.6e-14 Smith-Waterman score: 312; 29.8% identity (66.3% similar) in 181 aa overlap (18-197:9-177) 10 20 30 40 50 pF1KB4 MSFIFDWIYSGFSSVLQFLGLY-KKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHP : ::. :: .....::: :::::.:. :: .. .::. NP_001 MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGF 10 20 30 40 50 60 70 80 90 100 110 pF1KB4 TSEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDSLM . : . ...::..:.::. . : .:..:. .:..:.:: :.::. :..::: .. NP_001 NVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRML 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB4 TDETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSISLKELNARPLEVFMCS ... . .. .:...:: : :.:.. .. . .::. ::.. : . :. NP_001 AEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLH---------SLRHRNWYIQAT--CA 120 130 140 150 160 180 190 pF1KB4 VLKRQGYGEGFRWMAQYID . . .: ::. :... . NP_001 T-SGDGLYEGLDWLSNQLRNQK 170 180 198 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 06:07:29 2016 done: Sat Nov 5 06:07:30 2016 Total Scan time: 5.620 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]