FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4940, 479 aa 1>>>pF1KB4940 479 - 479 aa - 479 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.7937+/-0.000405; mu= -9.7637+/- 0.025 mean_var=563.6114+/-127.902, 0's: 0 Z-trim(125.0): 936 B-trim: 2170 in 1/61 Lambda= 0.054024 statistics sampled from 46398 (47854) to 46398 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.839), E-opt: 0.2 (0.561), width: 16 Scan time: 12.820 The best scores are: opt bits E(85289) NP_004226 (OMIM: 602253) Krueppel-like factor 4 is ( 479) 3406 280.0 9.9e-75 NP_001300981 (OMIM: 602253) Krueppel-like factor 4 ( 513) 2670 222.7 1.9e-57 NP_057354 (OMIM: 602016) Krueppel-like factor 2 [H ( 355) 823 78.5 3.3e-14 XP_011525944 (OMIM: 111150,600599,613566,613673) P ( 324) 684 67.7 5.6e-11 NP_006554 (OMIM: 111150,600599,613566,613673) Krue ( 362) 684 67.7 6.1e-11 XP_016863768 (OMIM: 609392) PREDICTED: Krueppel-li ( 320) 582 59.7 1.4e-08 NP_057615 (OMIM: 609392) Krueppel-like factor 3 [H ( 345) 582 59.8 1.5e-08 XP_011529061 (OMIM: 300286) PREDICTED: Krueppel-li ( 354) 572 59.0 2.5e-08 XP_016884739 (OMIM: 300286) PREDICTED: Krueppel-li ( 354) 572 59.0 2.5e-08 NP_001311034 (OMIM: 300286) Krueppel-like factor 8 ( 356) 564 58.4 3.9e-08 XP_005262036 (OMIM: 300286) PREDICTED: Krueppel-li ( 359) 564 58.4 3.9e-08 NP_009181 (OMIM: 300286) Krueppel-like factor 8 is ( 359) 564 58.4 3.9e-08 XP_005262034 (OMIM: 300286) PREDICTED: Krueppel-li ( 359) 564 58.4 3.9e-08 NP_001311031 (OMIM: 300286) Krueppel-like factor 8 ( 359) 564 58.4 3.9e-08 NP_001311033 (OMIM: 300286) Krueppel-like factor 8 ( 364) 564 58.4 4e-08 NP_001273747 (OMIM: 602903) Krueppel-like factor 5 ( 366) 562 58.2 4.4e-08 NP_001721 (OMIM: 602903) Krueppel-like factor 5 is ( 457) 562 58.3 5.1e-08 NP_001291 (OMIM: 176807,602053,613659) Krueppel-li ( 283) 540 56.4 1.2e-07 NP_001257872 (OMIM: 604865) Krueppel-like factor 7 ( 269) 524 55.1 2.8e-07 NP_001257873 (OMIM: 604865) Krueppel-like factor 7 ( 274) 524 55.1 2.9e-07 XP_016875874 (OMIM: 607531) PREDICTED: Krueppel-li ( 352) 526 55.4 3e-07 XP_016860650 (OMIM: 604865) PREDICTED: Krueppel-li ( 302) 524 55.2 3.1e-07 NP_003700 (OMIM: 604865) Krueppel-like factor 7 is ( 302) 524 55.2 3.1e-07 XP_011533213 (OMIM: 607531) PREDICTED: Krueppel-li ( 383) 526 55.4 3.2e-07 XP_011533214 (OMIM: 607531) PREDICTED: Krueppel-li ( 383) 526 55.4 3.2e-07 XP_016875873 (OMIM: 607531) PREDICTED: Krueppel-li ( 393) 526 55.5 3.3e-07 XP_011533212 (OMIM: 607531) PREDICTED: Krueppel-li ( 400) 526 55.5 3.3e-07 XP_005266308 (OMIM: 607531) PREDICTED: Krueppel-li ( 402) 526 55.5 3.3e-07 NP_009180 (OMIM: 607531) Krueppel-like factor 12 [ ( 402) 526 55.5 3.3e-07 XP_011533211 (OMIM: 607531) PREDICTED: Krueppel-li ( 402) 526 55.5 3.3e-07 XP_011533209 (OMIM: 607531) PREDICTED: Krueppel-li ( 415) 526 55.5 3.4e-07 XP_011510376 (OMIM: 604865) PREDICTED: Krueppel-li ( 270) 512 54.2 5.5e-07 XP_011510375 (OMIM: 604865) PREDICTED: Krueppel-li ( 272) 512 54.2 5.5e-07 XP_016860651 (OMIM: 604865) PREDICTED: Krueppel-li ( 275) 512 54.2 5.5e-07 XP_006712878 (OMIM: 604865) PREDICTED: Krueppel-li ( 303) 512 54.2 5.9e-07 XP_005246983 (OMIM: 604865) PREDICTED: Krueppel-li ( 303) 512 54.2 5.9e-07 XP_011510374 (OMIM: 604865) PREDICTED: Krueppel-li ( 303) 512 54.2 5.9e-07 NP_054798 (OMIM: 606465) Krueppel-like factor 15 [ ( 416) 499 53.4 1.4e-06 XP_005247457 (OMIM: 606465) PREDICTED: Krueppel-li ( 416) 499 53.4 1.4e-06 XP_011511045 (OMIM: 606465) PREDICTED: Krueppel-li ( 435) 499 53.4 1.5e-06 XP_011539002 (OMIM: 609602) PREDICTED: Krueppel-li ( 352) 494 52.9 1.7e-06 NP_775755 (OMIM: 609602) Krueppel-like factor 17 [ ( 389) 494 53.0 1.8e-06 NP_114124 (OMIM: 606139) Krueppel-like factor 16 [ ( 252) 458 49.9 9.6e-06 NP_057079 (OMIM: 605328,612001) Krueppel-like fact ( 288) 454 49.7 1.3e-05 NP_001027453 (OMIM: 601878) Krueppel-like factor 1 ( 469) 450 49.6 2.2e-05 NP_005646 (OMIM: 601878) Krueppel-like factor 10 i ( 480) 450 49.6 2.2e-05 NP_001171189 (OMIM: 603301,610508) Krueppel-like f ( 495) 448 49.5 2.5e-05 NP_001171187 (OMIM: 603301,610508) Krueppel-like f ( 495) 448 49.5 2.5e-05 NP_003588 (OMIM: 603301,610508) Krueppel-like fact ( 512) 448 49.5 2.6e-05 NP_001003845 (OMIM: 609391) transcription factor S ( 398) 442 48.9 3.1e-05 >>NP_004226 (OMIM: 602253) Krueppel-like factor 4 isofor (479 aa) initn: 3406 init1: 3406 opt: 3406 Z-score: 1462.6 bits: 280.0 E(85289): 9.9e-75 Smith-Waterman score: 3406; 100.0% identity (100.0% similar) in 479 aa overlap (1-479:1-479) 10 20 30 40 50 60 pF1KB4 MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRQAGAPNNRWREELSHMKRLPPVLPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRQAGAPNNRWREELSHMKRLPPVLPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 RPYDLAAATVATDLESGGAGAACGGSNLAPLPRRETEEFNDLLDLDFILSNSLTHPPESV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RPYDLAAATVATDLESGGAGAACGGSNLAPLPRRETEEFNDLLDLDFILSNSLTHPPESV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 AATVSSSASASSSSSPSSSGPASAPSTCSFTYPIRAGNDPGVAPGGTGGGLLYGRESAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AATVSSSASASSSSSPSSSGPASAPSTCSFTYPIRAGNDPGVAPGGTGGGLLYGRESAPP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 PTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLSAPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLSAPGS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 EYGSPSVISVSKGSPDGSHPVVVAPYNGGPPRTCPKIKQEAVSSCTHLGAGPPLSNGHRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EYGSPSVISVSKGSPDGSHPVVVAPYNGGPPRTCPKIKQEAVSSCTHLGAGPPLSNGHRP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 AAHDFPLGRQLPSRTTPTLGLEEVLSSRDCHPALPLPPGFHPHPGPNYPSFLPDQMQPQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AAHDFPLGRQLPSRTTPTLGLEEVLSSRDCHPALPLPPGFHPHPGPNYPSFLPDQMQPQV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 PPLHYQELMPPGSCMPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PPLHYQELMPPGSCMPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTH 370 380 390 400 410 420 430 440 450 460 470 pF1KB4 TGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF 430 440 450 460 470 >>NP_001300981 (OMIM: 602253) Krueppel-like factor 4 iso (513 aa) initn: 2657 init1: 2542 opt: 2670 Z-score: 1152.3 bits: 222.7 E(85289): 1.9e-57 Smith-Waterman score: 3310; 93.3% identity (93.3% similar) in 511 aa overlap (1-477:1-511) 10 20 30 40 50 60 pF1KB4 MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRQAGAPNNRWREELSHMKRLPPVLPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRQAGAPNNRWREELSHMKRLPPVLPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 RPYDLAAATVATDLESGGAGAACGGSNLAPLPRRETEEFNDLLDLDFILSNSLTHPPESV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPYDLAAATVATDLESGGAGAACGGSNLAPLPRRETEEFNDLLDLDFILSNSLTHPPESV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 AATVSSSASASSSSSPSSSGPASAPSTCSFTYPIRAGNDPGVAPGGTGGGLLYGRESAPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AATVSSSASASSSSSPSSSGPASAPSTCSFTYPIRAGNDPGVAPGGTGGGLLYGRESAPP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 PTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLSAPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLSAPGS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 EYGSPSVISVSKGSPDGSHPVVVAPYNGGPPRTCPKIKQEAVSSCTHLGAGPPLSNGHRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYGSPSVISVSKGSPDGSHPVVVAPYNGGPPRTCPKIKQEAVSSCTHLGAGPPLSNGHRP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 AAHDFPLGRQLPSRTTPTLGLEEVLSSRDCHPALPLPPGFHPHPGPNYPSFLPDQMQPQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAHDFPLGRQLPSRTTPTLGLEEVLSSRDCHPALPLPPGFHPHPGPNYPSFLPDQMQPQV 310 320 330 340 350 360 370 380 pF1KB4 PPLHYQ----------------------------------ELMPPGSCMPEEPKPKRGRR :::::: :::::::::::::::::::: NP_001 PPLHYQGQSRGFVARAGEPCVCWPHFGTHGMMLTPPSSPLELMPPGSCMPEEPKPKRGRR 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB4 SWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRH 430 440 450 460 470 480 450 460 470 pF1KB4 YRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF ::::::::::::::::::::::::::::::: NP_001 YRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF 490 500 510 >>NP_057354 (OMIM: 602016) Krueppel-like factor 2 [Homo (355 aa) initn: 866 init1: 729 opt: 823 Z-score: 376.1 bits: 78.5 E(85289): 3.3e-14 Smith-Waterman score: 892; 44.7% identity (58.7% similar) in 380 aa overlap (118-478:5-354) 90 100 110 120 130 140 pF1KB4 LAPLPRRETEEFNDLLDLDFILSNSLTHPPESVAATVSSSASASSSSSPSSSGPASAPST : . . :. :: . . : . : . NP_057 MALSEPILPSFSTFASPCRERGLQERWPRAEPES 10 20 30 150 160 170 180 190 200 pF1KB4 CSFTYPIRAGNDPGVAPGGTGGGLLYGRESAPPPTAP-FNLADIND----VSPSGGFVAE . . . : .. : : : . : ::: : : . . .:.::.:.: NP_057 GGTDDDLNSVLDFILSMGLDGLGAEAAPEPPPPPPPPAFYYPEPGAPPPYSAPAGGLVSE 40 50 60 70 80 90 210 220 230 240 250 260 pF1KB4 LLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLSAPGSEYGSPSVISVSKGSPDGSHPVV ::::::: : : .: :.:. :. :: .... ::. NP_057 LLRPELD---------APLGPALHGRFL----LAPPGR------LVKAEPPEADGGGGYG 100 110 120 130 270 280 290 300 310 pF1KB4 VAPYNGGPPRTCPKIKQEAV----SSCTHLGAGPPLSNGHRPAAHDFP-LGRQLPSRTTP :: :: .:.:.. .:: . :: .:. : : : :. . :.: : NP_057 CAPGLTRGPRG---LKREGAPGPAASCMR---GP---GGRPPPPPDTPPLSPDGPARL-P 140 150 160 170 180 320 330 340 350 360 pF1KB4 TLGLEEVLSSRDCHPALPLP-PGFHPHPGPNYPSF-LPDQMQPQV------PPLHYQELM . : . . :.. : ::.: : : :.: : :. . :: : NP_057 APGPRASFPPPFGGPGFGAPGPGLHYAP-PAPPAFGLFDDAAAAAAALGLAPPAARGLLT 190 200 210 220 230 240 370 380 390 400 410 420 pF1KB4 PPGSCMPE-EPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHC ::.: . : :::::::::::::::::::.::::::::::::::::::::::::::::: NP_057 PPASPLELLEAKPKRGRRSWPRKRTATHTCSYAGCGKTYTKSSHLKAHLRTHTGEKPYHC 250 260 270 280 290 300 430 440 450 460 470 pF1KB4 DWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF .:::::::::::::::::::::::::::::. :::::::::::::::::: NP_057 NWDGCGWKFARSDELTRHYRKHTGHRPFQCHLCDRAFSRSDHLALHMKRHM 310 320 330 340 350 >>XP_011525944 (OMIM: 111150,600599,613566,613673) PREDI (324 aa) initn: 810 init1: 633 opt: 684 Z-score: 318.0 bits: 67.7 E(85289): 5.6e-11 Smith-Waterman score: 687; 47.7% identity (61.5% similar) in 262 aa overlap (239-479:76-324) 210 220 230 240 250 260 pF1KB4 DPVYIPPQQPQPPGGGLMGKFVLKASLSAPGSEYGSPSVISVSKGSPDGS---HPVVVAP :. :.:.... :: : : .:.. : XP_011 GPEPGGAPQTCALAPSEASGAQYPPPPETLGAYAGGPGLVAGLLGSEDHSGWVRPALRAR 50 60 70 80 90 100 270 280 290 300 310 pF1KB4 YNG---GP---PRTCPKIKQEAVSSCTHLGAGPPLSNGHRPAAHDFPLGRQLPSRTTPTL :: : :. : :.. .. : : :.:. : . : ..:. . XP_011 APDAFVGPALAPAPAPEPKALALQP-VYPGPGAGSSGGYFPRT-----GLSVPAASGAPY 110 120 130 140 150 320 330 340 350 360 pF1KB4 GLEEVLSSRDCHPAL-PLPP---------GFH-PHPGP-NYPSFLPDQMQPQVPPLHYQE :: ::. .::. : : :.. : ::: . :::: : XP_011 GL---LSG---YPAMYPAPQYQGHFQLFRGLQGPAPGPATSPSFLSCLGPGTVGTGLGGT 160 170 180 190 200 210 370 380 390 400 410 420 pF1KB4 LMPPGSCMPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYH :: . : ::::::: ::: :.::: . ::::.:::::::::::::::::::: XP_011 AEDPG-VIAETAPSKRGRRSWARKRQAAHTCAHPGCGKSYTKSSHLKAHLRTHTGEKPYA 220 230 240 250 260 270 430 440 450 460 470 pF1KB4 CDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF : :.::::.::::::::::::::::.:::.:: : ::::::::::::::::. XP_011 CTWEGCGWRFARSDELTRHYRKHTGQRPFRCQLCPRAFSRSDHLALHMKRHL 280 290 300 310 320 >>NP_006554 (OMIM: 111150,600599,613566,613673) Krueppel (362 aa) initn: 815 init1: 633 opt: 684 Z-score: 317.5 bits: 67.7 E(85289): 6.1e-11 Smith-Waterman score: 687; 47.7% identity (61.5% similar) in 262 aa overlap (239-479:114-362) 210 220 230 240 250 260 pF1KB4 DPVYIPPQQPQPPGGGLMGKFVLKASLSAPGSEYGSPSVISVSKGSPDGS---HPVVVAP :. :.:.... :: : : .:.. : NP_006 GPEPGGAPQTCALAPSEASGAQYPPPPETLGAYAGGPGLVAGLLGSEDHSGWVRPALRAR 90 100 110 120 130 140 270 280 290 300 310 pF1KB4 YNG---GP---PRTCPKIKQEAVSSCTHLGAGPPLSNGHRPAAHDFPLGRQLPSRTTPTL :: : :. : :.. .. : : :.:. : . : ..:. . NP_006 APDAFVGPALAPAPAPEPKALALQP-VYPGPGAGSSGGYFPRT-----GLSVPAASGAPY 150 160 170 180 190 320 330 340 350 360 pF1KB4 GLEEVLSSRDCHPAL-PLPP---------GFH-PHPGP-NYPSFLPDQMQPQVPPLHYQE :: ::. .::. : : :.. : ::: . :::: : NP_006 GL---LSG---YPAMYPAPQYQGHFQLFRGLQGPAPGPATSPSFLSCLGPGTVGTGLGGT 200 210 220 230 240 250 370 380 390 400 410 420 pF1KB4 LMPPGSCMPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYH :: . : ::::::: ::: :.::: . ::::.:::::::::::::::::::: NP_006 AEDPG-VIAETAPSKRGRRSWARKRQAAHTCAHPGCGKSYTKSSHLKAHLRTHTGEKPYA 260 270 280 290 300 310 430 440 450 460 470 pF1KB4 CDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF : :.::::.::::::::::::::::.:::.:: : ::::::::::::::::. NP_006 CTWEGCGWRFARSDELTRHYRKHTGQRPFRCQLCPRAFSRSDHLALHMKRHL 320 330 340 350 360 >>XP_016863768 (OMIM: 609392) PREDICTED: Krueppel-like f (320 aa) initn: 568 init1: 525 opt: 582 Z-score: 275.1 bits: 59.7 E(85289): 1.4e-08 Smith-Waterman score: 591; 38.7% identity (58.6% similar) in 292 aa overlap (207-478:33-317) 180 190 200 210 220 230 pF1KB4 SAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIP-PQQPQPPGGGLMG---KFVLK ...:: . .. .::..: :: . XP_016 SMKPNKYGVIYSTPLPEKFFQTPEGLSHGIQMEPVDLTVNKRSSPPSAGNSPSSLKFPSS 10 20 30 40 50 60 240 250 260 270 280 290 pF1KB4 ASLSAPGSEY--GSPSVISVSKGSPDGSHPVVVAPYNGGPPRTCPKIKQEAVSSCTHLGA ..:: . .:: . . : :: : .: : : . :: ...... : : . XP_016 HRRASPGLSMPSSSPPIKKYSPPSP-GVQPFGV-PLSM-PPVMAAALSRHGIRSPGILPV 70 80 90 100 110 300 310 320 330 pF1KB4 GPPLSNGHRPAAHDFPLGRQLPSRTTPTLGLEEVLSSRDC-------HPA----LPLPPG :. .:. . : : .. . .:. :: . .: . . :: XP_016 IQPVVV--QPVPFMYTSHLQQPLMVSLSEEMENSSSSMQVPVIESYEKPISQKKIKIEPG 120 130 140 150 160 170 340 350 360 370 380 390 pF1KB4 FHPHPGPNYPSFL-PDQMQPQVPPLHY-QELMPPGSCMP-EEPKPKRGRRSWPRKRTATH ..:. :: . : :. :: :: : .: ..: : .. . ..: : XP_016 IEPQRTDYYPEEMSPPLMNSVSPPQALLQENHPSVIVQPGKRPLPVESPDTQRKRRI--H 180 190 200 210 220 230 400 410 420 430 440 450 pF1KB4 TCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPF ::: ::.:.:::::::::: :::::::::.: :.:: ::::::::::::.::::: .:: XP_016 RCDYDGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPF 240 250 260 270 280 290 460 470 pF1KB4 QCQKCDRAFSRSDHLALHMKRHF :: :::.:::::::::: ::: XP_016 QCPDCDRSFSRSDHLALHRKRHMLV 300 310 320 >>NP_057615 (OMIM: 609392) Krueppel-like factor 3 [Homo (345 aa) initn: 547 init1: 525 opt: 582 Z-score: 274.7 bits: 59.8 E(85289): 1.5e-08 Smith-Waterman score: 591; 38.7% identity (58.6% similar) in 292 aa overlap (207-478:58-342) 180 190 200 210 220 230 pF1KB4 SAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIP-PQQPQPPGGGLMG---KFVLK ...:: . .. .::..: :: . NP_057 SMKPNKYGVIYSTPLPEKFFQTPEGLSHGIQMEPVDLTVNKRSSPPSAGNSPSSLKFPSS 30 40 50 60 70 80 240 250 260 270 280 290 pF1KB4 ASLSAPGSEY--GSPSVISVSKGSPDGSHPVVVAPYNGGPPRTCPKIKQEAVSSCTHLGA ..:: . .:: . . : :: : .: : : . :: ...... : : . NP_057 HRRASPGLSMPSSSPPIKKYSPPSP-GVQPFGV-PLSM-PPVMAAALSRHGIRSPGILPV 90 100 110 120 130 140 300 310 320 330 pF1KB4 GPPLSNGHRPAAHDFPLGRQLPSRTTPTLGLEEVLSSRDC-------HPA----LPLPPG :. .:. . : : .. . .:. :: . .: . . :: NP_057 IQPVVV--QPVPFMYTSHLQQPLMVSLSEEMENSSSSMQVPVIESYEKPISQKKIKIEPG 150 160 170 180 190 200 340 350 360 370 380 390 pF1KB4 FHPHPGPNYPSFL-PDQMQPQVPPLHY-QELMPPGSCMP-EEPKPKRGRRSWPRKRTATH ..:. :: . : :. :: :: : .: ..: : .. . ..: : NP_057 IEPQRTDYYPEEMSPPLMNSVSPPQALLQENHPSVIVQPGKRPLPVESPDTQRKRRI--H 210 220 230 240 250 260 400 410 420 430 440 450 pF1KB4 TCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPF ::: ::.:.:::::::::: :::::::::.: :.:: ::::::::::::.::::: .:: NP_057 RCDYDGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPF 270 280 290 300 310 320 460 470 pF1KB4 QCQKCDRAFSRSDHLALHMKRHF :: :::.:::::::::: ::: NP_057 QCPDCDRSFSRSDHLALHRKRHMLV 330 340 >>XP_011529061 (OMIM: 300286) PREDICTED: Krueppel-like f (354 aa) initn: 535 init1: 513 opt: 572 Z-score: 270.4 bits: 59.0 E(85289): 2.5e-08 Smith-Waterman score: 598; 35.1% identity (55.6% similar) in 365 aa overlap (138-478:9-351) 110 120 130 140 150 160 pF1KB4 ILSNSLTHPPESVAATVSSSASASSSSSPSSSGPASAPS--TCSFTYPIRAGNDPGVA-- ::: .:. : : : .: . : . XP_011 MSLPEDGMSSGHFRSPQLVTWSVTASVRNRDPPEIEYR 10 20 30 170 180 190 200 210 220 pF1KB4 PGGTGGGLLYGRESAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGG . :. :: .: : : . ::. : ..... :...:: . ..:. : XP_011 SNMTSPTLL----DANPMENPALFNDIKIEPPEELLASDFSLPQVEPVDLSFHKPKAP-- 40 50 60 70 80 90 230 240 250 260 270 280 pF1KB4 GLMGKFVLKASLSAPGSEYGSPSVISVSKGSPDGSHPVVVAPYNGGPPRTCPKIKQEAVS :. .:.: . : . .::... :: .. : : . . : : ... XP_011 -LQPASMLQAPIRPPKPQ-SSPQTLVVSTSTSDMSTSANI------PTVLTPG---SVLT 100 110 120 130 140 290 300 310 320 330 pF1KB4 SCTHLGAGPPLSNGHRPAAHDFPLGRQLPSRTTPTL--GLEEVLSS--RDCHPA---LPL : :. : : . ..: ... .: :.. .: : .. : :: .:: XP_011 SSQSTGSQQILHVIHTIPSVSLP-NKMGGLKTIPVVVQSLPMVYTTLPADGGPAAITVPL 150 160 170 180 190 200 340 350 360 370 380 pF1KB4 PPGFHPHPGPNYPSFL--PDQMQP-QVPPLHYQELMPPGSC-------MPEEPKPK---R : : : : : .:.: ..: . . :: . .:: . XP_011 IGG----DGKNAGSVKVDPTSMSPLEIPSDSEESTIESGSSALQSLQGLQQEPAAMAQMQ 210 220 230 240 250 390 400 410 420 430 440 pF1KB4 GRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDEL :..: :: : ::.:::.:.:::::::::: : :::::::.: ::::.::::::::: XP_011 GEESLDLKRRRIHQCDFAGCSKVYTKSSHLKAHRRIHTGEKPYKCTWDGCSWKFARSDEL 260 270 280 290 300 310 450 460 470 pF1KB4 TRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF :::.::::: .::.: :.:.:::::::.:: .:: XP_011 TRHFRKHTGIKPFRCTDCNRSFSRSDHLSLHRRRHDTM 320 330 340 350 >>XP_016884739 (OMIM: 300286) PREDICTED: Krueppel-like f (354 aa) initn: 535 init1: 513 opt: 572 Z-score: 270.4 bits: 59.0 E(85289): 2.5e-08 Smith-Waterman score: 598; 35.1% identity (55.6% similar) in 365 aa overlap (138-478:9-351) 110 120 130 140 150 160 pF1KB4 ILSNSLTHPPESVAATVSSSASASSSSSPSSSGPASAPS--TCSFTYPIRAGNDPGVA-- ::: .:. : : : .: . : . XP_016 MSLPEDGMSSGHFRSPQLVTWSVTASVRNRDPPEIEYR 10 20 30 170 180 190 200 210 220 pF1KB4 PGGTGGGLLYGRESAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGG . :. :: .: : : . ::. : ..... :...:: . ..:. : XP_016 SNMTSPTLL----DANPMENPALFNDIKIEPPEELLASDFSLPQVEPVDLSFHKPKAP-- 40 50 60 70 80 90 230 240 250 260 270 280 pF1KB4 GLMGKFVLKASLSAPGSEYGSPSVISVSKGSPDGSHPVVVAPYNGGPPRTCPKIKQEAVS :. .:.: . : . .::... :: .. : : . . : : ... XP_016 -LQPASMLQAPIRPPKPQ-SSPQTLVVSTSTSDMSTSANI------PTVLTPG---SVLT 100 110 120 130 140 290 300 310 320 330 pF1KB4 SCTHLGAGPPLSNGHRPAAHDFPLGRQLPSRTTPTL--GLEEVLSS--RDCHPA---LPL : :. : : . ..: ... .: :.. .: : .. : :: .:: XP_016 SSQSTGSQQILHVIHTIPSVSLP-NKMGGLKTIPVVVQSLPMVYTTLPADGGPAAITVPL 150 160 170 180 190 200 340 350 360 370 380 pF1KB4 PPGFHPHPGPNYPSFL--PDQMQP-QVPPLHYQELMPPGSC-------MPEEPKPK---R : : : : : .:.: ..: . . :: . .:: . XP_016 IGG----DGKNAGSVKVDPTSMSPLEIPSDSEESTIESGSSALQSLQGLQQEPAAMAQMQ 210 220 230 240 250 390 400 410 420 430 440 pF1KB4 GRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDEL :..: :: : ::.:::.:.:::::::::: : :::::::.: ::::.::::::::: XP_016 GEESLDLKRRRIHQCDFAGCSKVYTKSSHLKAHRRIHTGEKPYKCTWDGCSWKFARSDEL 260 270 280 290 300 310 450 460 470 pF1KB4 TRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF :::.::::: .::.: :.:.:::::::.:: .:: XP_016 TRHFRKHTGIKPFRCTDCNRSFSRSDHLSLHRRRHDTM 320 330 340 350 >>NP_001311034 (OMIM: 300286) Krueppel-like factor 8 iso (356 aa) initn: 535 init1: 513 opt: 564 Z-score: 267.0 bits: 58.4 E(85289): 3.9e-08 Smith-Waterman score: 590; 36.1% identity (57.0% similar) in 321 aa overlap (178-478:51-353) 150 160 170 180 190 200 pF1KB4 CSFTYPIRAGNDPGVAPGGTGGGLLYGRESAPPPTAPFNLADINDVSPSGGFVAELLRPE : : : . ::. : ..... :. NP_001 VFKQVTASVRNRDPPEIEYRSNMTSPTLLDANPMENPALFNDIKIEPPEELLASDFSLPQ 30 40 50 60 70 80 210 220 230 240 250 260 pF1KB4 LDPVYIPPQQPQPPGGGLMGKFVLKASLSAPGSEYGSPSVISVSKGSPDGSHPVVVAPYN ..:: . ..:. : :. .:.: . : . .::... :: .. : : . . NP_001 VEPVDLSFHKPKAP---LQPASMLQAPIRPPKPQ-SSPQTLVVSTSTSDMSTSANI---- 90 100 110 120 130 270 280 290 300 310 320 pF1KB4 GGPPRTCPKIKQEAVSSCTHLGAGPPLSNGHRPAAHDFPLGRQLPSRTTPTL--GLEEVL : : ...: :. : : . ..: ... .: :.. .: : NP_001 --PTVLTPG---SVLTSSQSTGSQQILHVIHTIPSVSLP-NKMGGLKTIPVVVQSLPMVY 140 150 160 170 180 330 340 350 360 370 pF1KB4 SS--RDCHPA---LPLPPGFHPHPGPNYPSFL--PDQMQP-QVPPLHYQELMPPGSC--- .. : :: .:: : : : : : .:.: ..: . . :: NP_001 TTLPADGGPAAITVPLIGG----DGKNAGSVKVDPTSMSPLEIPSDSEESTIESGSSALQ 190 200 210 220 230 240 380 390 400 410 420 pF1KB4 ----MPEEPKPK---RGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYH . .:: .:..: :: : ::.:::.:.:::::::::: : :::::::. NP_001 SLQGLQQEPAAMAQMQGEESLDLKRRRIHQCDFAGCSKVYTKSSHLKAHRRIHTGEKPYK 250 260 270 280 290 300 430 440 450 460 470 pF1KB4 CDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF : ::::.::::::::::::.::::: .::.: :.:.:::::::.:: .:: NP_001 CTWDGCSWKFARSDELTRHFRKHTGIKPFRCTDCNRSFSRSDHLSLHRRRHDTM 310 320 330 340 350 479 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 15:36:43 2016 done: Thu Nov 3 15:36:45 2016 Total Scan time: 12.820 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]