FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4976, 418 aa 1>>>pF1KB4976 418 - 418 aa - 418 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4552+/-0.000303; mu= 17.3673+/- 0.019 mean_var=78.2214+/-15.661, 0's: 0 Z-trim(117.4): 28 B-trim: 49 in 3/54 Lambda= 0.145014 statistics sampled from 29281 (29310) to 29281 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.709), E-opt: 0.2 (0.344), width: 16 Scan time: 8.540 The best scores are: opt bits E(85289) NP_004032 (OMIM: 107940) beta-arrestin-1 isoform A ( 418) 2776 590.0 3.6e-168 XP_011543336 (OMIM: 107940) PREDICTED: beta-arrest ( 449) 2736 581.7 1.3e-165 NP_064647 (OMIM: 107940) beta-arrestin-1 isoform B ( 410) 2704 575.0 1.2e-163 XP_011543337 (OMIM: 107940) PREDICTED: beta-arrest ( 441) 2664 566.6 4.2e-161 XP_016873241 (OMIM: 107940) PREDICTED: beta-arrest ( 442) 2532 539.0 8.7e-153 XP_016873239 (OMIM: 107940) PREDICTED: beta-arrest ( 473) 2492 530.7 3e-150 XP_016873242 (OMIM: 107940) PREDICTED: beta-arrest ( 437) 2483 528.8 1.1e-149 XP_016873243 (OMIM: 107940) PREDICTED: beta-arrest ( 434) 2460 523.9 2.9e-148 XP_016873240 (OMIM: 107940) PREDICTED: beta-arrest ( 465) 2420 515.6 1e-145 NP_004304 (OMIM: 107941) beta-arrestin-2 isoform 1 ( 409) 2150 459.1 9.4e-129 XP_011522160 (OMIM: 107941) PREDICTED: beta-arrest ( 440) 2126 454.1 3.2e-127 NP_001244259 (OMIM: 107941) beta-arrestin-2 isofor ( 421) 2005 428.7 1.3e-119 NP_945355 (OMIM: 107941) beta-arrestin-2 isoform 2 ( 394) 1865 399.4 8.1e-111 NP_001244260 (OMIM: 107941) beta-arrestin-2 isofor ( 406) 1720 369.1 1.1e-101 NP_004303 (OMIM: 301770) arrestin-C [Homo sapiens] ( 388) 1545 332.5 1.1e-90 NP_001244257 (OMIM: 107941) beta-arrestin-2 isofor ( 430) 1514 326.0 1.1e-88 NP_001244258 (OMIM: 107941) beta-arrestin-2 isofor ( 330) 1479 318.6 1.4e-86 NP_000532 (OMIM: 181031,258100,613758) S-arrestin ( 405) 1475 317.8 3e-86 XP_016860131 (OMIM: 181031,258100,613758) PREDICTE ( 369) 1473 317.4 3.7e-86 XP_016860130 (OMIM: 181031,258100,613758) PREDICTE ( 373) 1473 317.4 3.8e-86 XP_016885007 (OMIM: 301770) PREDICTED: arrestin-C ( 403) 1374 296.7 6.9e-80 NP_001316993 (OMIM: 107941) beta-arrestin-2 isofor ( 217) 1064 231.7 1.4e-60 XP_016860132 (OMIM: 181031,258100,613758) PREDICTE ( 273) 1047 228.2 2e-59 XP_011509895 (OMIM: 181031,258100,613758) PREDICTE ( 305) 1025 223.6 5.3e-58 XP_011509896 (OMIM: 181031,258100,613758) PREDICTE ( 281) 1017 221.9 1.6e-57 XP_011509898 (OMIM: 181031,258100,613758) PREDICTE ( 271) 973 212.7 9e-55 XP_016880134 (OMIM: 107941) PREDICTED: beta-arrest ( 229) 919 201.4 2e-51 >>NP_004032 (OMIM: 107940) beta-arrestin-1 isoform A [Ho (418 aa) initn: 2776 init1: 2776 opt: 2776 Z-score: 3140.2 bits: 590.0 E(85289): 3.6e-168 Smith-Waterman score: 2776; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KB4 MGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 FRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 PNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 QPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 ICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 ASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEP 310 320 330 340 350 360 370 380 390 400 410 pF1KB4 PHREVPENETPVDTNLIELDTNDDDIVFEDFARQRLKGMKDDKEEEEDGTGSPQLNNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PHREVPENETPVDTNLIELDTNDDDIVFEDFARQRLKGMKDDKEEEEDGTGSPQLNNR 370 380 390 400 410 >>XP_011543336 (OMIM: 107940) PREDICTED: beta-arrestin-1 (449 aa) initn: 2736 init1: 2736 opt: 2736 Z-score: 3094.5 bits: 581.7 E(85289): 1.3e-165 Smith-Waterman score: 2736; 99.8% identity (100.0% similar) in 413 aa overlap (6-418:37-449) 10 20 30 pF1KB4 MGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVD .::::::::::::::::::::::::::::: XP_011 RERLRLHARRIQTLAFHPPQHPGAGCVALLSRVFKKASPNGKLTVYLGKRDFVDHIDLVD 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB4 PVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKK 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB4 PLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLE 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB4 EKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPIS 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB4 VNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLT 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB4 PFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLL 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB4 GDLASSDVAVELPFTLMHPKPKEEPPHREVPENETPVDTNLIELDTNDDDIVFEDFARQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GDLASSDVAVELPFTLMHPKPKEEPPHREVPENETPVDTNLIELDTNDDDIVFEDFARQR 370 380 390 400 410 420 400 410 pF1KB4 LKGMKDDKEEEEDGTGSPQLNNR ::::::::::::::::::::::: XP_011 LKGMKDDKEEEEDGTGSPQLNNR 430 440 >>NP_064647 (OMIM: 107940) beta-arrestin-1 isoform B [Ho (410 aa) initn: 2716 init1: 2204 opt: 2704 Z-score: 3058.9 bits: 575.0 E(85289): 1.2e-163 Smith-Waterman score: 2704; 98.1% identity (98.1% similar) in 418 aa overlap (1-418:1-410) 10 20 30 40 50 60 pF1KB4 MGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 MGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 FRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 FRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 PNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 PNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 QPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 QPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 ICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 ICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 ASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEP ::::::::::::::::::::::::::::::::: ::::::::::::::::::: NP_064 ASSTLLREGANREILGIIVSYKVKVKLVVSRGG--------DVAVELPFTLMHPKPKEEP 310 320 330 340 350 370 380 390 400 410 pF1KB4 PHREVPENETPVDTNLIELDTNDDDIVFEDFARQRLKGMKDDKEEEEDGTGSPQLNNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 PHREVPENETPVDTNLIELDTNDDDIVFEDFARQRLKGMKDDKEEEEDGTGSPQLNNR 360 370 380 390 400 410 >>XP_011543337 (OMIM: 107940) PREDICTED: beta-arrestin-1 (441 aa) initn: 2676 init1: 2164 opt: 2664 Z-score: 3013.2 bits: 566.6 E(85289): 4.2e-161 Smith-Waterman score: 2664; 97.8% identity (98.1% similar) in 413 aa overlap (6-418:37-441) 10 20 30 pF1KB4 MGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVD .::::::::::::::::::::::::::::: XP_011 RERLRLHARRIQTLAFHPPQHPGAGCVALLSRVFKKASPNGKLTVYLGKRDFVDHIDLVD 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB4 PVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKK 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB4 PLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLE 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB4 EKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPIS 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB4 VNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLT 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB4 PFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGG-- 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB4 GDLASSDVAVELPFTLMHPKPKEEPPHREVPENETPVDTNLIELDTNDDDIVFEDFARQR :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ------DVAVELPFTLMHPKPKEEPPHREVPENETPVDTNLIELDTNDDDIVFEDFARQR 370 380 390 400 410 400 410 pF1KB4 LKGMKDDKEEEEDGTGSPQLNNR ::::::::::::::::::::::: XP_011 LKGMKDDKEEEEDGTGSPQLNNR 420 430 440 >>XP_016873241 (OMIM: 107940) PREDICTED: beta-arrestin-1 (442 aa) initn: 2532 init1: 2532 opt: 2532 Z-score: 2864.0 bits: 539.0 E(85289): 8.7e-153 Smith-Waterman score: 2718; 94.6% identity (94.6% similar) in 442 aa overlap (1-418:1-442) 10 20 30 40 50 60 pF1KB4 MGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 FRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 PNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 QPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 ICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 ASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEP 310 320 330 340 350 360 370 380 390 pF1KB4 PHREVPENETPVDTNLIELDTN------------------------DDDIVFEDFARQRL :::::::::::::::::::::: :::::::::::::: XP_016 PHREVPENETPVDTNLIELDTNQRPSSHRTVARGGGPGPTARTASSDDDIVFEDFARQRL 370 380 390 400 410 420 400 410 pF1KB4 KGMKDDKEEEEDGTGSPQLNNR :::::::::::::::::::::: XP_016 KGMKDDKEEEEDGTGSPQLNNR 430 440 >>XP_016873239 (OMIM: 107940) PREDICTED: beta-arrestin-1 (473 aa) initn: 2492 init1: 2492 opt: 2492 Z-score: 2818.3 bits: 530.7 E(85289): 3e-150 Smith-Waterman score: 2678; 94.3% identity (94.5% similar) in 437 aa overlap (6-418:37-473) 10 20 30 pF1KB4 MGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVD .::::::::::::::::::::::::::::: XP_016 RERLRLHARRIQTLAFHPPQHPGAGCVALLSRVFKKASPNGKLTVYLGKRDFVDHIDLVD 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB4 PVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKK 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB4 PLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLE 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB4 EKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPIS 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB4 VNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLT 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB4 PFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLL 310 320 330 340 350 360 340 350 360 370 380 pF1KB4 GDLASSDVAVELPFTLMHPKPKEEPPHREVPENETPVDTNLIELDTN------------- ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDLASSDVAVELPFTLMHPKPKEEPPHREVPENETPVDTNLIELDTNQRPSSHRTVARGG 370 380 390 400 410 420 390 400 410 pF1KB4 -----------DDDIVFEDFARQRLKGMKDDKEEEEDGTGSPQLNNR :::::::::::::::::::::::::::::::::::: XP_016 GPGPTARTASSDDDIVFEDFARQRLKGMKDDKEEEEDGTGSPQLNNR 430 440 450 460 470 >>XP_016873242 (OMIM: 107940) PREDICTED: beta-arrestin-1 (437 aa) initn: 2483 init1: 2483 opt: 2483 Z-score: 2808.7 bits: 528.8 E(85289): 1.1e-149 Smith-Waterman score: 2669; 94.5% identity (94.5% similar) in 435 aa overlap (8-418:3-437) 10 20 30 40 50 60 pF1KB4 MGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCA ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCA 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 FRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIP 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB4 PNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGP 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB4 QPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYAD 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB4 ICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNL 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB4 ASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEP 300 310 320 330 340 350 370 380 390 pF1KB4 PHREVPENETPVDTNLIELDTN------------------------DDDIVFEDFARQRL :::::::::::::::::::::: :::::::::::::: XP_016 PHREVPENETPVDTNLIELDTNQRPSSHRTVARGGGPGPTARTASSDDDIVFEDFARQRL 360 370 380 390 400 410 400 410 pF1KB4 KGMKDDKEEEEDGTGSPQLNNR :::::::::::::::::::::: XP_016 KGMKDDKEEEEDGTGSPQLNNR 420 430 >>XP_016873243 (OMIM: 107940) PREDICTED: beta-arrestin-1 (434 aa) initn: 2472 init1: 2204 opt: 2460 Z-score: 2782.7 bits: 523.9 E(85289): 2.9e-148 Smith-Waterman score: 2646; 92.8% identity (92.8% similar) in 442 aa overlap (1-418:1-434) 10 20 30 40 50 60 pF1KB4 MGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 FRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 PNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 QPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 ICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 ASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEP ::::::::::::::::::::::::::::::::: ::::::::::::::::::: XP_016 ASSTLLREGANREILGIIVSYKVKVKLVVSRGG--------DVAVELPFTLMHPKPKEEP 310 320 330 340 350 370 380 390 pF1KB4 PHREVPENETPVDTNLIELDTN------------------------DDDIVFEDFARQRL :::::::::::::::::::::: :::::::::::::: XP_016 PHREVPENETPVDTNLIELDTNQRPSSHRTVARGGGPGPTARTASSDDDIVFEDFARQRL 360 370 380 390 400 410 400 410 pF1KB4 KGMKDDKEEEEDGTGSPQLNNR :::::::::::::::::::::: XP_016 KGMKDDKEEEEDGTGSPQLNNR 420 430 >>XP_016873240 (OMIM: 107940) PREDICTED: beta-arrestin-1 (465 aa) initn: 2432 init1: 2164 opt: 2420 Z-score: 2737.0 bits: 515.6 E(85289): 1e-145 Smith-Waterman score: 2606; 92.4% identity (92.7% similar) in 437 aa overlap (6-418:37-465) 10 20 30 pF1KB4 MGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVD .::::::::::::::::::::::::::::: XP_016 RERLRLHARRIQTLAFHPPQHPGAGCVALLSRVFKKASPNGKLTVYLGKRDFVDHIDLVD 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB4 PVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKK 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB4 PLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLE 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB4 EKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPIS 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB4 VNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLT 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB4 PFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGG-- 310 320 330 340 350 360 340 350 360 370 380 pF1KB4 GDLASSDVAVELPFTLMHPKPKEEPPHREVPENETPVDTNLIELDTN------------- ::::::::::::::::::::::::::::::::::::::::: XP_016 ------DVAVELPFTLMHPKPKEEPPHREVPENETPVDTNLIELDTNQRPSSHRTVARGG 370 380 390 400 410 390 400 410 pF1KB4 -----------DDDIVFEDFARQRLKGMKDDKEEEEDGTGSPQLNNR :::::::::::::::::::::::::::::::::::: XP_016 GPGPTARTASSDDDIVFEDFARQRLKGMKDDKEEEEDGTGSPQLNNR 420 430 440 450 460 >>NP_004304 (OMIM: 107941) beta-arrestin-2 isoform 1 [Ho (409 aa) initn: 2079 init1: 1870 opt: 2150 Z-score: 2432.5 bits: 459.1 E(85289): 9.4e-129 Smith-Waterman score: 2150; 76.4% identity (91.6% similar) in 415 aa overlap (1-407:1-407) 10 20 30 40 50 pF1KB4 MGDK-GTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTC ::.: :::::::.::: ::::::::::::::.: ::::::::::::.:::.:.:.::::: NP_004 MGEKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB4 AFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEI ::::::::::::::.::::::.:. :.:::.:. .: ::::.::..:::.::.:: : : NP_004 AFRYGREDLDVLGLSFRKDLFIATYQAFPPVPNPPRPPTRLQDRLLRKLGQHAHPFFFTI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB4 PPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPG : ::::::::::::::::::::::.:..::::..:::: ::::::::::::::.:::.:: NP_004 PQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSLEEKSHKRNSVRLVIRKVQFAPEKPG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB4 PQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYA :::.:::::.:::::. ::::::::::.::::::..::::::::..:::::::.:::::: NP_004 PQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB4 DICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTN :::::.:::::::::. : :: :.::::::::::.::.:..::::::::::::::::::: NP_004 DICLFSTAQYKCPVAQLEQDDQVSPSSTFCKVYTITPLLSDNREKRGLALDGKLKHEDTN 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB4 LASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEE :::::...::::.:.:::.:::.::::::::::: ::.:::::.::::::... NP_004 LASSTIVKEGANKEVLGILVSYRVKVKLVVSRGG--------DVSVELPFVLMHPKPHDH 310 320 330 340 350 360 370 380 390 400 410 pF1KB4 -P---PHREVPENETPVDTNLIELDTN---DDDIVFEDFARQRLKGMKDDKEEEEDGTGS : :. .::...::::::::.::: ::::::::::: :::::::: ... NP_004 IPLPRPQSAAPETDVPVDTNLIEFDTNYATDDDIVFEDFARLRLKGMKDDDYDDQLC 360 370 380 390 400 pF1KB4 PQLNNR 418 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 03:19:24 2016 done: Fri Nov 4 03:19:25 2016 Total Scan time: 8.540 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]