FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4977, 400 aa 1>>>pF1KB4977 400 - 400 aa - 400 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3898+/-0.000414; mu= 11.8676+/- 0.026 mean_var=116.4731+/-24.627, 0's: 0 Z-trim(113.9): 180 B-trim: 353 in 2/54 Lambda= 0.118840 statistics sampled from 23308 (23533) to 23308 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.642), E-opt: 0.2 (0.276), width: 16 Scan time: 6.730 The best scores are: opt bits E(85289) NP_003788 (OMIM: 605984) polycomb protein EED isof ( 441) 2783 488.6 1.3e-137 XP_016874001 (OMIM: 605984) PREDICTED: polycomb pr ( 403) 2777 487.5 2.4e-137 XP_011543633 (OMIM: 605984) PREDICTED: polycomb pr ( 415) 2224 392.7 8.7e-109 XP_011543632 (OMIM: 605984) PREDICTED: polycomb pr ( 428) 2224 392.7 8.9e-109 NP_001294936 (OMIM: 605984) polycomb protein EED i ( 466) 2224 392.7 9.5e-109 XP_016874002 (OMIM: 605984) PREDICTED: polycomb pr ( 323) 1655 295.1 1.7e-79 NP_001317263 (OMIM: 605984) polycomb protein EED i ( 361) 1655 295.1 1.8e-79 NP_004362 (OMIM: 601924,616414) coatomer subunit a (1224) 188 44.0 0.0024 NP_001091868 (OMIM: 601924,616414) coatomer subuni (1233) 188 44.0 0.0024 NP_001186706 (OMIM: 614784,615973) POC1 centriolar ( 436) 181 42.4 0.0025 NP_758440 (OMIM: 614784,615973) POC1 centriolar pr ( 478) 181 42.5 0.0027 XP_016861593 (OMIM: 614783,614813) PREDICTED: POC1 ( 321) 172 40.8 0.0058 NP_942593 (OMIM: 610767,611081) autophagy-related ( 444) 174 41.2 0.0058 XP_005246143 (OMIM: 610767,611081) PREDICTED: auto ( 463) 174 41.3 0.006 XP_005246141 (OMIM: 610767,611081) PREDICTED: auto ( 480) 174 41.3 0.0062 NP_001155052 (OMIM: 614783,614813) POC1 centriolar ( 359) 172 40.8 0.0063 NP_001177196 (OMIM: 610767,611081) autophagy-relat ( 491) 174 41.3 0.0063 NP_001155053 (OMIM: 614783,614813) POC1 centriolar ( 369) 172 40.8 0.0064 NP_001177195 (OMIM: 610767,611081) autophagy-relat ( 523) 174 41.3 0.0066 XP_006712671 (OMIM: 610767,611081) PREDICTED: auto ( 540) 174 41.3 0.0067 NP_056241 (OMIM: 614783,614813) POC1 centriolar pr ( 407) 172 40.9 0.0069 NP_060444 (OMIM: 610767,611081) autophagy-related ( 588) 174 41.3 0.0072 NP_110430 (OMIM: 610767,611081) autophagy-related ( 607) 174 41.4 0.0074 XP_005246139 (OMIM: 610767,611081) PREDICTED: auto ( 624) 174 41.4 0.0075 NP_001269469 (OMIM: 604596) CMT1A duplicated regio ( 714) 174 41.4 0.0083 XP_016879510 (OMIM: 611679) PREDICTED: F-box/WD re ( 724) 174 41.4 0.0084 XP_011521928 (OMIM: 611679) PREDICTED: F-box/WD re ( 745) 174 41.4 0.0086 NP_006373 (OMIM: 604596) CMT1A duplicated region t ( 752) 174 41.4 0.0087 XP_011521927 (OMIM: 611679) PREDICTED: F-box/WD re ( 856) 174 41.5 0.0095 XP_016879509 (OMIM: 611679) PREDICTED: F-box/WD re ( 856) 174 41.5 0.0095 >>NP_003788 (OMIM: 605984) polycomb protein EED isoform (441 aa) initn: 2783 init1: 2783 opt: 2783 Z-score: 2591.7 bits: 488.6 E(85289): 1.3e-137 Smith-Waterman score: 2783; 100.0% identity (100.0% similar) in 400 aa overlap (1-400:1-400) 10 20 30 40 50 60 pF1KB4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ 310 320 330 340 350 360 370 380 390 400 pF1KB4 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAK :::::::::::::::::::::::::::::::::::::::: NP_003 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR 370 380 390 400 410 420 NP_003 DSSILIAVCDDASIWRWDRLR 430 440 >>XP_016874001 (OMIM: 605984) PREDICTED: polycomb protei (403 aa) initn: 2777 init1: 2777 opt: 2777 Z-score: 2586.7 bits: 487.5 E(85289): 2.4e-137 Smith-Waterman score: 2777; 100.0% identity (100.0% similar) in 399 aa overlap (1-399:1-399) 10 20 30 40 50 60 pF1KB4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ 310 320 330 340 350 360 370 380 390 400 pF1KB4 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAK ::::::::::::::::::::::::::::::::::::::: XP_016 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKANRDH 370 380 390 400 >>XP_011543633 (OMIM: 605984) PREDICTED: polycomb protei (415 aa) initn: 2223 init1: 2223 opt: 2224 Z-score: 2074.1 bits: 392.7 E(85289): 8.7e-109 Smith-Waterman score: 2552; 93.8% identity (93.8% similar) in 400 aa overlap (1-375:1-400) 10 20 30 40 50 60 pF1KB4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS 250 260 270 280 290 300 310 320 330 pF1KB4 TRDIHRNYVDCVRWLGDLILSKS-------------------------CENAIVCWKPGK ::::::::::::::::::::::: :::::::::::: XP_011 TRDIHRNYVDCVRWLGDLILSKSGRAILHSHQQCMRDPVSPNLRQHLSCENAIVCWKPGK 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB4 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED :::::::::::::::::::::::::::::::::::::::: XP_011 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKEYKTQRNSQEHRGWN 370 380 390 400 410 400 pF1KB4 PHKAK >>XP_011543632 (OMIM: 605984) PREDICTED: polycomb protei (428 aa) initn: 2223 init1: 2223 opt: 2224 Z-score: 2073.9 bits: 392.7 E(85289): 8.9e-109 Smith-Waterman score: 2717; 94.1% identity (94.1% similar) in 424 aa overlap (1-399:1-424) 10 20 30 40 50 60 pF1KB4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS 250 260 270 280 290 300 310 320 330 pF1KB4 TRDIHRNYVDCVRWLGDLILSKS-------------------------CENAIVCWKPGK ::::::::::::::::::::::: :::::::::::: XP_011 TRDIHRNYVDCVRWLGDLILSKSGRAILHSHQQCMRDPVSPNLRQHLSCENAIVCWKPGK 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB4 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED 370 380 390 400 410 420 400 pF1KB4 PHKAK :::: XP_011 PHKANRDH >>NP_001294936 (OMIM: 605984) polycomb protein EED isofo (466 aa) initn: 2223 init1: 2223 opt: 2224 Z-score: 2073.4 bits: 392.7 E(85289): 9.5e-109 Smith-Waterman score: 2723; 94.1% identity (94.1% similar) in 425 aa overlap (1-400:1-425) 10 20 30 40 50 60 pF1KB4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS 250 260 270 280 290 300 310 320 330 pF1KB4 TRDIHRNYVDCVRWLGDLILSKS-------------------------CENAIVCWKPGK ::::::::::::::::::::::: :::::::::::: NP_001 TRDIHRNYVDCVRWLGDLILSKSGRAILHSHQQCMRDPVSPNLRQHLSCENAIVCWKPGK 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB4 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED 370 380 390 400 410 420 400 pF1KB4 PHKAK ::::: NP_001 PHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 430 440 450 460 >>XP_016874002 (OMIM: 605984) PREDICTED: polycomb protei (323 aa) initn: 1677 init1: 1655 opt: 1655 Z-score: 1548.3 bits: 295.1 E(85289): 1.7e-79 Smith-Waterman score: 2044; 79.9% identity (79.9% similar) in 399 aa overlap (1-399:1-319) 10 20 30 40 50 60 pF1KB4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS :: XP_016 SA---------------------------------------------------------- 310 320 330 340 350 360 pF1KB4 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ :::::::::::::::::::::::::::::::::::::: XP_016 ----------------------SCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ 250 260 270 280 370 380 390 400 pF1KB4 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAK ::::::::::::::::::::::::::::::::::::::: XP_016 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKANRDH 290 300 310 320 >>NP_001317263 (OMIM: 605984) polycomb protein EED isofo (361 aa) initn: 1655 init1: 1655 opt: 1655 Z-score: 1547.7 bits: 295.1 E(85289): 1.8e-79 Smith-Waterman score: 2050; 80.0% identity (80.0% similar) in 400 aa overlap (1-400:1-320) 10 20 30 40 50 60 pF1KB4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS :: NP_001 SA---------------------------------------------------------- 310 320 330 340 350 360 pF1KB4 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ :::::::::::::::::::::::::::::::::::::: NP_001 ----------------------SCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ 250 260 270 280 370 380 390 400 pF1KB4 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAK :::::::::::::::::::::::::::::::::::::::: NP_001 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR 290 300 310 320 330 340 NP_001 DSSILIAVCDDASIWRWDRLR 350 360 >>NP_004362 (OMIM: 601924,616414) coatomer subunit alpha (1224 aa) initn: 116 init1: 67 opt: 188 Z-score: 181.1 bits: 44.0 E(85289): 0.0024 Smith-Waterman score: 191; 21.3% identity (53.3% similar) in 244 aa overlap (155-391:58-278) 130 140 150 160 170 180 pF1KB4 ECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIK : . ..::.. .:. :.. : .:. NP_004 LHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLF 30 40 50 60 70 80 190 200 210 220 230 240 pF1KB4 HYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY .:: . : :: . : .::.: :...:.:: :. : : .. :: :. :.. NP_004 TLLGHLDYIRTTFFHHEYP-WILSASDDQTIRVWNWQSRTCVCVL---TGHNHYVMCAQF 90 100 110 120 130 140 250 260 270 280 290 300 pF1KB4 DLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHF--PDFSTR . ..: ..:.....: :.. : :.. . . ... :. : : .. NP_004 HPTEDLVVSASLDQTVRVWDISGLR-----KKNLSPGAVESDVRGITGVDLFGTTDAVVK 150 160 170 180 190 310 320 330 340 350 pF1KB4 DIHRNYVDCVRWLG-----DLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFD . ... : : . ::.: . . . :. ... : : . : :... NP_004 HVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWR-------MNESKAWEVD-TCRGHYN 200 210 220 230 240 250 360 370 380 390 400 pF1KB4 YSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAK .: ... : :... ... .. :::. NP_004 NVSCAVFHPR------QELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLN 260 270 280 290 300 NP_004 LFAAGHDGGMIVFKLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFP 310 320 330 340 350 360 >>NP_001091868 (OMIM: 601924,616414) coatomer subunit al (1233 aa) initn: 116 init1: 67 opt: 188 Z-score: 181.1 bits: 44.0 E(85289): 0.0024 Smith-Waterman score: 191; 21.3% identity (53.3% similar) in 244 aa overlap (155-391:58-278) 130 140 150 160 170 180 pF1KB4 ECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIK : . ..::.. .:. :.. : .:. NP_001 LHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLF 30 40 50 60 70 80 190 200 210 220 230 240 pF1KB4 HYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY .:: . : :: . : .::.: :...:.:: :. : : .. :: :. :.. NP_001 TLLGHLDYIRTTFFHHEYP-WILSASDDQTIRVWNWQSRTCVCVL---TGHNHYVMCAQF 90 100 110 120 130 140 250 260 270 280 290 300 pF1KB4 DLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHF--PDFSTR . ..: ..:.....: :.. : :.. . . ... :. : : .. NP_001 HPTEDLVVSASLDQTVRVWDISGLR-----KKNLSPGAVESDVRGITGVDLFGTTDAVVK 150 160 170 180 190 310 320 330 340 350 pF1KB4 DIHRNYVDCVRWLG-----DLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFD . ... : : . ::.: . . . :. ... : : . : :... NP_001 HVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWR-------MNESKAWEVD-TCRGHYN 200 210 220 230 240 250 360 370 380 390 400 pF1KB4 YSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAK .: ... : :... ... .. :::. NP_001 NVSCAVFHPR------QELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLN 260 270 280 290 300 NP_001 LFAAGHDGGMIVFKLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFP 310 320 330 340 350 360 >>NP_001186706 (OMIM: 614784,615973) POC1 centriolar pro (436 aa) initn: 166 init1: 82 opt: 181 Z-score: 180.8 bits: 42.4 E(85289): 0.0025 Smith-Waterman score: 181; 28.6% identity (61.6% similar) in 112 aa overlap (155-266:151-258) 130 140 150 160 170 180 pF1KB4 ECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIK : : : .: ::: ... . . . .. NP_001 SEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 HYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY :: :....: ..::: . : :...:.: .:.. .. :. ..:: :..... NP_001 HYQVHSGGVNCISFHP-SGNYLITASSDGTLKILDLLEGRLIYT---LQGHTGPVFTVSF 190 200 210 220 230 250 260 270 280 290 300 pF1KB4 DLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDI . :: . : : : .. ::: : NP_001 SKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEE 240 250 260 270 280 290 400 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 03:19:58 2016 done: Fri Nov 4 03:19:59 2016 Total Scan time: 6.730 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]