FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5014, 417 aa 1>>>pF1KB5014 417 - 417 aa - 417 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.7266+/-0.000443; mu= -2.0858+/- 0.028 mean_var=327.9992+/-65.459, 0's: 0 Z-trim(120.8): 12 B-trim: 292 in 1/54 Lambda= 0.070817 statistics sampled from 36481 (36498) to 36481 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.743), E-opt: 0.2 (0.428), width: 16 Scan time: 9.240 The best scores are: opt bits E(85289) NP_004334 (OMIM: 109091,187950,254450) calreticuli ( 417) 2915 311.5 2.5e-84 NP_659483 (OMIM: 611414,613875) calreticulin-3 pre ( 384) 951 110.8 6e-24 NP_001737 (OMIM: 114217) calnexin precursor [Homo ( 592) 472 62.1 4.4e-09 NP_001019820 (OMIM: 114217) calnexin precursor [Ho ( 592) 472 62.1 4.4e-09 XP_011532967 (OMIM: 114217) PREDICTED: calnexin is ( 592) 472 62.1 4.4e-09 XP_011532966 (OMIM: 114217) PREDICTED: calnexin is ( 646) 472 62.1 4.6e-09 NP_004353 (OMIM: 601858) calmegin precursor [Homo ( 610) 419 56.7 1.9e-07 NP_001124147 (OMIM: 601858) calmegin precursor [Ho ( 610) 419 56.7 1.9e-07 >>NP_004334 (OMIM: 109091,187950,254450) calreticulin pr (417 aa) initn: 2915 init1: 2915 opt: 2915 Z-score: 1634.9 bits: 311.5 E(85289): 2.5e-84 Smith-Waterman score: 2915; 100.0% identity (100.0% similar) in 417 aa overlap (1-417:1-417) 10 20 30 40 50 60 pF1KB5 MLLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MLLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 EKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 DMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 TYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDKPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDKPE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 HIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDK 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 QDEEQRLKEEEEDKKRKEEEEAEDKEDDEDKDEDEEDEEDKEEDEEEDVPGQAKDEL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QDEEQRLKEEEEDKKRKEEEEAEDKEDDEDKDEDEEDEEDKEEDEEEDVPGQAKDEL 370 380 390 400 410 >>NP_659483 (OMIM: 611414,613875) calreticulin-3 precurs (384 aa) initn: 1289 init1: 878 opt: 951 Z-score: 550.9 bits: 110.8 E(85289): 6e-24 Smith-Waterman score: 1312; 52.4% identity (76.8% similar) in 370 aa overlap (14-383:14-362) 10 20 30 40 50 60 pF1KB5 MLLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDE : :: .:::.:.::::. : .::..: . : ::.: :::::::: . NP_659 MARALVQLWAICMLRVALATVYFQEEFLDGEHWRNRWLQSTNDSRFGHFRLSSGKFYGHK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 EKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQT ::::::::.:..::::.:: :.::::::.:::.:.::::::..::::::.:.:: ..:: NP_659 EKDKGLQTTQNGRFYAISARFKPFSNKGKTLVIQYTVKHEQKMDCGGGYIKVFPADIDQK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 DMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDN ...: :.: ::::::::: ::::::...:.: .: :::: : ::::::::.::: NP_659 NLNGKSQYYIMFGPDICGFDIKKVHVILHFKNKYHENKKLIRCKVDGFTHLYTLILRPDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 TYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDKPE .:.::::....::::.: ::.. :: .: :: :: :..: :.: .::.: NP_659 SYDVKIDGQSIESGSIEYDWNLTSLKKETSPAESK--DW-EQTK-----DNKAQDWEK-- 190 200 210 220 230 250 260 270 280 290 300 pF1KB5 HIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYS :. : ...: ::. ..::.: :..:.: :. ::. : .: .:.: .. : .: NP_659 HFLDASTSKQSDWNGDLDGDWPAPMLQKPPYQDGLKPEGI----HKDVWLHRKMKNTDYL 240 250 260 270 280 310 320 330 340 350 360 pF1KB5 PDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDK . .. ..:.:..::.::::.:::::::::::.:: ::..::. ::: ::. :..: NP_659 TQYDLSEFENIGAIGLELWQVRSGTIFDNFLITDDEEYADNFGKATWGETKGPEREM--- 290 300 310 320 330 340 370 380 390 400 410 pF1KB5 QDEEQRLKEEEEDKKRKEEEEAEDKEDDEDKDEDEEDEEDKEEDEEEDVPGQAKDEL . .. .:: :: .:::: : NP_659 ----DAIQAKEEMKKAREEEEEELLSGKINRHEHYFNQFHRRNEL 350 360 370 380 >>NP_001737 (OMIM: 114217) calnexin precursor [Homo sapi (592 aa) initn: 494 init1: 326 opt: 472 Z-score: 284.1 bits: 62.1 E(85289): 4.4e-09 Smith-Waterman score: 904; 36.5% identity (57.8% similar) in 479 aa overlap (32-408:78-555) 10 20 30 40 50 pF1KB5 LLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESKHKSDF--GKFVLSSGKFYGD : : :: :: :.: ... .::. . NP_001 DTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKKDDTDDEIAKYDGKWEVE 50 60 70 80 90 100 60 70 80 90 100 110 pF1KB5 EEK------DKGLQTSQDARFYALSASF-EPFSNKGQTLVVQFTVKHEQNIDCGGGYVKL : : :::: . :. .:.::.. .:: . :.::. :. ...:.:::.:::: NP_001 EMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKL 110 120 130 140 150 160 120 130 140 150 160 pF1KB5 FPNS--LDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCK------ . .. :. ..: . :.:::::: :: : .: :: .:. .. : .. . : NP_001 LSKTPELNLDQFHDKTPYTIMFGPDKCGEDYK-LHFIFRHKNPKTGIYEEKHAKRPDADL 170 180 190 200 210 220 170 180 190 200 210 pF1KB5 ----DDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWD--FLPPKKIKDPDASKPED :. :::::::. :::..:. .:.: :.::.: .: : ..:.::. :::: NP_001 KTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREIEDPEDRKPED 230 240 250 260 270 280 220 230 240 250 pF1KB5 WDERAKIDDPTDSKPEDWDK---------------------PEHIPDPDAKKPEDWDEEM :::: :: :: ::.:::. ::..:::::.:::::::.: NP_001 WDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDM 290 300 310 320 330 340 260 270 280 290 pF1KB5 DGEWE-P------------------PVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPE ::::: : :::.::.:::.::: .::::.:.: : .: ::. NP_001 DGEWEAPQIANPRCESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPD 350 360 370 380 390 400 300 310 320 330 340 350 pF1KB5 YSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEK--- . : . . :...::.::.. : .::::.: :. .....:. ::. :::. NP_001 FFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDWANDGWGLKKAADGAAE 410 420 430 440 450 460 360 370 380 pF1KB5 -----QMKDKQDEEQRL----------------------KEEEEDKKRKE--------EE :: . .:. : :.. . :. .: NP_001 PGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQTSGMEYKKTDAPQPDVKE 470 480 490 500 510 520 390 400 410 pF1KB5 EAEDKEDDEDK-DEDEEDEEDKEEDEEEDVPGQAKDEL : :.::...:: ::.:: :: :: .. : NP_001 EEEEKEEEKDKGDEEEEGEEKLEEKQKSDAEEDGGTVSQEEEDRKPKAEEDEILNRSPRN 530 540 550 560 570 580 >>NP_001019820 (OMIM: 114217) calnexin precursor [Homo s (592 aa) initn: 494 init1: 326 opt: 472 Z-score: 284.1 bits: 62.1 E(85289): 4.4e-09 Smith-Waterman score: 904; 36.5% identity (57.8% similar) in 479 aa overlap (32-408:78-555) 10 20 30 40 50 pF1KB5 LLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESKHKSDF--GKFVLSSGKFYGD : : :: :: :.: ... .::. . NP_001 DTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKKDDTDDEIAKYDGKWEVE 50 60 70 80 90 100 60 70 80 90 100 110 pF1KB5 EEK------DKGLQTSQDARFYALSASF-EPFSNKGQTLVVQFTVKHEQNIDCGGGYVKL : : :::: . :. .:.::.. .:: . :.::. :. ...:.:::.:::: NP_001 EMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKL 110 120 130 140 150 160 120 130 140 150 160 pF1KB5 FPNS--LDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCK------ . .. :. ..: . :.:::::: :: : .: :: .:. .. : .. . : NP_001 LSKTPELNLDQFHDKTPYTIMFGPDKCGEDYK-LHFIFRHKNPKTGIYEEKHAKRPDADL 170 180 190 200 210 220 170 180 190 200 210 pF1KB5 ----DDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWD--FLPPKKIKDPDASKPED :. :::::::. :::..:. .:.: :.::.: .: : ..:.::. :::: NP_001 KTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREIEDPEDRKPED 230 240 250 260 270 280 220 230 240 250 pF1KB5 WDERAKIDDPTDSKPEDWDK---------------------PEHIPDPDAKKPEDWDEEM :::: :: :: ::.:::. ::..:::::.:::::::.: NP_001 WDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDM 290 300 310 320 330 340 260 270 280 290 pF1KB5 DGEWE-P------------------PVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPE ::::: : :::.::.:::.::: .::::.:.: : .: ::. NP_001 DGEWEAPQIANPRCESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPD 350 360 370 380 390 400 300 310 320 330 340 350 pF1KB5 YSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEK--- . : . . :...::.::.. : .::::.: :. .....:. ::. :::. NP_001 FFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDWANDGWGLKKAADGAAE 410 420 430 440 450 460 360 370 380 pF1KB5 -----QMKDKQDEEQRL----------------------KEEEEDKKRKE--------EE :: . .:. : :.. . :. .: NP_001 PGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQTSGMEYKKTDAPQPDVKE 470 480 490 500 510 520 390 400 410 pF1KB5 EAEDKEDDEDK-DEDEEDEEDKEEDEEEDVPGQAKDEL : :.::...:: ::.:: :: :: .. : NP_001 EEEEKEEEKDKGDEEEEGEEKLEEKQKSDAEEDGGTVSQEEEDRKPKAEEDEILNRSPRN 530 540 550 560 570 580 >>XP_011532967 (OMIM: 114217) PREDICTED: calnexin isofor (592 aa) initn: 494 init1: 326 opt: 472 Z-score: 284.1 bits: 62.1 E(85289): 4.4e-09 Smith-Waterman score: 904; 36.5% identity (57.8% similar) in 479 aa overlap (32-408:78-555) 10 20 30 40 50 pF1KB5 LLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESKHKSDF--GKFVLSSGKFYGD : : :: :: :.: ... .::. . XP_011 DTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKKDDTDDEIAKYDGKWEVE 50 60 70 80 90 100 60 70 80 90 100 110 pF1KB5 EEK------DKGLQTSQDARFYALSASF-EPFSNKGQTLVVQFTVKHEQNIDCGGGYVKL : : :::: . :. .:.::.. .:: . :.::. :. ...:.:::.:::: XP_011 EMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKL 110 120 130 140 150 160 120 130 140 150 160 pF1KB5 FPNS--LDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCK------ . .. :. ..: . :.:::::: :: : .: :: .:. .. : .. . : XP_011 LSKTPELNLDQFHDKTPYTIMFGPDKCGEDYK-LHFIFRHKNPKTGIYEEKHAKRPDADL 170 180 190 200 210 220 170 180 190 200 210 pF1KB5 ----DDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWD--FLPPKKIKDPDASKPED :. :::::::. :::..:. .:.: :.::.: .: : ..:.::. :::: XP_011 KTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREIEDPEDRKPED 230 240 250 260 270 280 220 230 240 250 pF1KB5 WDERAKIDDPTDSKPEDWDK---------------------PEHIPDPDAKKPEDWDEEM :::: :: :: ::.:::. ::..:::::.:::::::.: XP_011 WDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDM 290 300 310 320 330 340 260 270 280 290 pF1KB5 DGEWE-P------------------PVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPE ::::: : :::.::.:::.::: .::::.:.: : .: ::. XP_011 DGEWEAPQIANPRCESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPD 350 360 370 380 390 400 300 310 320 330 340 350 pF1KB5 YSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEK--- . : . . :...::.::.. : .::::.: :. .....:. ::. :::. XP_011 FFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDWANDGWGLKKAADGAAE 410 420 430 440 450 460 360 370 380 pF1KB5 -----QMKDKQDEEQRL----------------------KEEEEDKKRKE--------EE :: . .:. : :.. . :. .: XP_011 PGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQTSGMEYKKTDAPQPDVKE 470 480 490 500 510 520 390 400 410 pF1KB5 EAEDKEDDEDK-DEDEEDEEDKEEDEEEDVPGQAKDEL : :.::...:: ::.:: :: :: .. : XP_011 EEEEKEEEKDKGDEEEEGEEKLEEKQKSDAEEDGGTVSQEEEDRKPKAEEDEILNRSPRN 530 540 550 560 570 580 >>XP_011532966 (OMIM: 114217) PREDICTED: calnexin isofor (646 aa) initn: 494 init1: 326 opt: 472 Z-score: 283.6 bits: 62.1 E(85289): 4.6e-09 Smith-Waterman score: 904; 36.5% identity (57.8% similar) in 479 aa overlap (32-408:132-609) 10 20 30 40 50 pF1KB5 LLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESKHKSDF--GKFVLSSGKFYGD : : :: :: :.: ... .::. . XP_011 DTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKKDDTDDEIAKYDGKWEVE 110 120 130 140 150 160 60 70 80 90 100 110 pF1KB5 EEK------DKGLQTSQDARFYALSASF-EPFSNKGQTLVVQFTVKHEQNIDCGGGYVKL : : :::: . :. .:.::.. .:: . :.::. :. ...:.:::.:::: XP_011 EMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKL 170 180 190 200 210 220 120 130 140 150 160 pF1KB5 FPNS--LDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCK------ . .. :. ..: . :.:::::: :: : .: :: .:. .. : .. . : XP_011 LSKTPELNLDQFHDKTPYTIMFGPDKCGEDYK-LHFIFRHKNPKTGIYEEKHAKRPDADL 230 240 250 260 270 280 170 180 190 200 210 pF1KB5 ----DDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWD--FLPPKKIKDPDASKPED :. :::::::. :::..:. .:.: :.::.: .: : ..:.::. :::: XP_011 KTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREIEDPEDRKPED 290 300 310 320 330 340 220 230 240 250 pF1KB5 WDERAKIDDPTDSKPEDWDK---------------------PEHIPDPDAKKPEDWDEEM :::: :: :: ::.:::. ::..:::::.:::::::.: XP_011 WDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDM 350 360 370 380 390 400 260 270 280 290 pF1KB5 DGEWE-P------------------PVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPE ::::: : :::.::.:::.::: .::::.:.: : .: ::. XP_011 DGEWEAPQIANPRCESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPD 410 420 430 440 450 460 300 310 320 330 340 350 pF1KB5 YSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEK--- . : . . :...::.::.. : .::::.: :. .....:. ::. :::. XP_011 FFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDWANDGWGLKKAADGAAE 470 480 490 500 510 520 360 370 380 pF1KB5 -----QMKDKQDEEQRL----------------------KEEEEDKKRKE--------EE :: . .:. : :.. . :. .: XP_011 PGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQTSGMEYKKTDAPQPDVKE 530 540 550 560 570 580 390 400 410 pF1KB5 EAEDKEDDEDK-DEDEEDEEDKEEDEEEDVPGQAKDEL : :.::...:: ::.:: :: :: .. : XP_011 EEEEKEEEKDKGDEEEEGEEKLEEKQKSDAEEDGGTVSQEEEDRKPKAEEDEILNRSPRN 590 600 610 620 630 640 >>NP_004353 (OMIM: 601858) calmegin precursor [Homo sapi (610 aa) initn: 944 init1: 342 opt: 419 Z-score: 254.7 bits: 56.7 E(85289): 1.9e-07 Smith-Waterman score: 843; 38.5% identity (62.6% similar) in 377 aa overlap (32-347:69-444) 10 20 30 40 50 pF1KB5 LLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESK-HKSDFGKFV-LSSGKFYGD : . :. :: .:.:. . . . .:.. . NP_004 DVNESELSSEIKYKTPQPIGEVYFAETFDSGRLAGWVLSKAKKDDMDEEISIYDGRWEIE 40 50 60 70 80 90 60 70 80 90 100 110 pF1KB5 EEK------DKGLQTSQDARFYALSASF-EPFSNKGQTLVVQFTVKHEQNIDCGGGYVKL : : :.:: .. :. .:.:: . .:: . :.::. :. ...:::::.:.:: NP_004 ELKENQVPGDRGLVLKSRAKHHAISAVLAKPFIFADKPLIVQYEVNFQDGIDCGGAYIKL 100 110 120 130 140 150 120 130 140 150 160 pF1KB5 FPNSLDQT--DMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKN--VLINKDIRCKD--- . .. : ... . : :::::: :: : .: :: .: . :. .: . : NP_004 LADTDDLILENFYDKTSYIIMFGPDKCGEDYK-LHFIFRHKHPKTGVFEEKHAKPPDVDL 160 170 180 190 200 210 170 180 190 200 210 pF1KB5 -----DEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDW--DFLPPKKIKDPDASKPED :. ::::::.. ::.:.:: .:.. :..::: .: . :::.:.::. .:::. NP_004 KKFFTDRKTHLYTLVMNPDDTFEVLVDQTVVNKGSLLEDVVPPIKPPKEIEDPNDKKPEE 220 230 240 250 260 270 220 230 240 250 pF1KB5 WDERAKIDDPTDSKPEDWDK---------------------PEHIPDPDAKKPEDWDEEM ::::::: ::. ::::::. :. ::::.:.::.::.:. NP_004 WDERAKIPDPSAVKPEDWDESEPAQIEDSSVVKPAGWLDDEPKFIPDPNAEKPDDWNEDT 280 290 300 310 320 330 260 270 280 290 300 pF1KB5 DGEWEPPVIQNPEYK---GEWKPRQIDNPDYKGTWIHPEIDNPEYS--------PDPSIY ::::: : : :: . ::::: .:::: :::.: : .:::.:. :.:. . NP_004 DGEWEAPQILNPACRIGCGEWKPPMIDNPKYKGVWRPPLVDNPNYQGIWSPRKIPNPDYF 340 350 360 370 380 390 310 320 330 340 350 360 pF1KB5 AYDN------FGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDK :. :..:::.::.. : ::::.: ... :.... . : NP_004 EDDHPFLLTSFSALGLELWSMTSDIYFDNFIICSEKEVADHWAADGWRWKIMIANANKPG 400 410 420 430 440 450 370 380 390 400 410 pF1KB5 QDEEQRLKEEEEDKKRKEEEEAEDKEDDEDKDEDEEDEEDKEEDEEEDVPGQAKDEL NP_004 VLKQLMAAAEGHPWLWLIYLVTAGVPIALITSFCWPRKVKKKHKDTEYKKTDICIPQTKG 460 470 480 490 500 510 >>NP_001124147 (OMIM: 601858) calmegin precursor [Homo s (610 aa) initn: 944 init1: 342 opt: 419 Z-score: 254.7 bits: 56.7 E(85289): 1.9e-07 Smith-Waterman score: 843; 38.5% identity (62.6% similar) in 377 aa overlap (32-347:69-444) 10 20 30 40 50 pF1KB5 LLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESK-HKSDFGKFV-LSSGKFYGD : . :. :: .:.:. . . . .:.. . NP_001 DVNESELSSEIKYKTPQPIGEVYFAETFDSGRLAGWVLSKAKKDDMDEEISIYDGRWEIE 40 50 60 70 80 90 60 70 80 90 100 110 pF1KB5 EEK------DKGLQTSQDARFYALSASF-EPFSNKGQTLVVQFTVKHEQNIDCGGGYVKL : : :.:: .. :. .:.:: . .:: . :.::. :. ...:::::.:.:: NP_001 ELKENQVPGDRGLVLKSRAKHHAISAVLAKPFIFADKPLIVQYEVNFQDGIDCGGAYIKL 100 110 120 130 140 150 120 130 140 150 160 pF1KB5 FPNSLDQT--DMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKN--VLINKDIRCKD--- . .. : ... . : :::::: :: : .: :: .: . :. .: . : NP_001 LADTDDLILENFYDKTSYIIMFGPDKCGEDYK-LHFIFRHKHPKTGVFEEKHAKPPDVDL 160 170 180 190 200 210 170 180 190 200 210 pF1KB5 -----DEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDW--DFLPPKKIKDPDASKPED :. ::::::.. ::.:.:: .:.. :..::: .: . :::.:.::. .:::. NP_001 KKFFTDRKTHLYTLVMNPDDTFEVLVDQTVVNKGSLLEDVVPPIKPPKEIEDPNDKKPEE 220 230 240 250 260 270 220 230 240 250 pF1KB5 WDERAKIDDPTDSKPEDWDK---------------------PEHIPDPDAKKPEDWDEEM ::::::: ::. ::::::. :. ::::.:.::.::.:. NP_001 WDERAKIPDPSAVKPEDWDESEPAQIEDSSVVKPAGWLDDEPKFIPDPNAEKPDDWNEDT 280 290 300 310 320 330 260 270 280 290 300 pF1KB5 DGEWEPPVIQNPEYK---GEWKPRQIDNPDYKGTWIHPEIDNPEYS--------PDPSIY ::::: : : :: . ::::: .:::: :::.: : .:::.:. :.:. . NP_001 DGEWEAPQILNPACRIGCGEWKPPMIDNPKYKGVWRPPLVDNPNYQGIWSPRKIPNPDYF 340 350 360 370 380 390 310 320 330 340 350 360 pF1KB5 AYDN------FGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDK :. :..:::.::.. : ::::.: ... :.... . : NP_001 EDDHPFLLTSFSALGLELWSMTSDIYFDNFIICSEKEVADHWAADGWRWKIMIANANKPG 400 410 420 430 440 450 370 380 390 400 410 pF1KB5 QDEEQRLKEEEEDKKRKEEEEAEDKEDDEDKDEDEEDEEDKEEDEEEDVPGQAKDEL NP_001 VLKQLMAAAEGHPWLWLIYLVTAGVPIALITSFCWPRKVKKKHKDTEYKKTDICIPQTKG 460 470 480 490 500 510 417 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 15:46:03 2016 done: Thu Nov 3 15:46:05 2016 Total Scan time: 9.240 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]