FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5017, 338 aa 1>>>pF1KB5017 338 - 338 aa - 338 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.1257+/-0.000298; mu= 3.9182+/- 0.019 mean_var=168.1439+/-35.137, 0's: 0 Z-trim(121.8): 19 B-trim: 2154 in 1/53 Lambda= 0.098909 statistics sampled from 38885 (38904) to 38885 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.786), E-opt: 0.2 (0.456), width: 16 Scan time: 7.360 The best scores are: opt bits E(85289) NP_001231627 (OMIM: 601064) zinc finger protein 36 ( 338) 2302 339.9 4.5e-93 NP_004917 (OMIM: 601064) zinc finger protein 36, C ( 338) 2302 339.9 4.5e-93 NP_001231630 (OMIM: 601064) zinc finger protein 36 ( 407) 2302 340.0 5.3e-93 NP_008818 (OMIM: 612053) zinc finger protein 36, C ( 494) 674 107.7 5.3e-23 NP_003398 (OMIM: 190700) tristetraprolin [Homo sap ( 332) 509 84.1 4.7e-16 >>NP_001231627 (OMIM: 601064) zinc finger protein 36, C3 (338 aa) initn: 2302 init1: 2302 opt: 2302 Z-score: 1791.9 bits: 339.9 E(85289): 4.5e-93 Smith-Waterman score: 2302; 100.0% identity (100.0% similar) in 338 aa overlap (1-338:1-338) 10 20 30 40 50 60 pF1KB5 MTTTLVSATIFDLSEVLCKGNKMLNYSAPSAGGCLLDRKAVGTPAGGGFPRRHSVTLPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTTTLVSATIFDLSEVLCKGNKMLNYSAPSAGGCLLDRKAVGTPAGGGFPRRHSVTLPSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 KFHQNQLLSSLKGEPAPALSSRDSRFRDRSFSEGGERLLPTQKQPGGGQVNSSRYKTELC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KFHQNQLLSSLKGEPAPALSSRDSRFRDRSFSEGGERLLPTQKQPGGGQVNSSRYKTELC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 RPFEENGACKYGDKCQFAHGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPFEENGACKYGDKCQFAHGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNAE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 ERRALAGARDLSADRPRLQHSFSFAGFPSAAATAAATGLLDSPTSITPPPILSADDLLGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERRALAGARDLSADRPRLQHSFSFAGFPSAAATAAATGLLDSPTSITPPPILSADDLLGS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 PTLPDGTNNPFAFSSQELASLFAPSMGLPGGGSPTTFLFRPMSESPHMFDSPPSPQDSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTLPDGTNNPFAFSSQELASLFAPSMGLPGGGSPTTFLFRPMSESPHMFDSPPSPQDSLS 250 260 270 280 290 300 310 320 330 pF1KB5 DQEGYLSSSSSSHSGSDSPTLDNSRRLPIFSRLSISDD :::::::::::::::::::::::::::::::::::::: NP_001 DQEGYLSSSSSSHSGSDSPTLDNSRRLPIFSRLSISDD 310 320 330 >>NP_004917 (OMIM: 601064) zinc finger protein 36, C3H1 (338 aa) initn: 2302 init1: 2302 opt: 2302 Z-score: 1791.9 bits: 339.9 E(85289): 4.5e-93 Smith-Waterman score: 2302; 100.0% identity (100.0% similar) in 338 aa overlap (1-338:1-338) 10 20 30 40 50 60 pF1KB5 MTTTLVSATIFDLSEVLCKGNKMLNYSAPSAGGCLLDRKAVGTPAGGGFPRRHSVTLPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MTTTLVSATIFDLSEVLCKGNKMLNYSAPSAGGCLLDRKAVGTPAGGGFPRRHSVTLPSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 KFHQNQLLSSLKGEPAPALSSRDSRFRDRSFSEGGERLLPTQKQPGGGQVNSSRYKTELC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KFHQNQLLSSLKGEPAPALSSRDSRFRDRSFSEGGERLLPTQKQPGGGQVNSSRYKTELC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 RPFEENGACKYGDKCQFAHGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RPFEENGACKYGDKCQFAHGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNAE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 ERRALAGARDLSADRPRLQHSFSFAGFPSAAATAAATGLLDSPTSITPPPILSADDLLGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ERRALAGARDLSADRPRLQHSFSFAGFPSAAATAAATGLLDSPTSITPPPILSADDLLGS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 PTLPDGTNNPFAFSSQELASLFAPSMGLPGGGSPTTFLFRPMSESPHMFDSPPSPQDSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PTLPDGTNNPFAFSSQELASLFAPSMGLPGGGSPTTFLFRPMSESPHMFDSPPSPQDSLS 250 260 270 280 290 300 310 320 330 pF1KB5 DQEGYLSSSSSSHSGSDSPTLDNSRRLPIFSRLSISDD :::::::::::::::::::::::::::::::::::::: NP_004 DQEGYLSSSSSSHSGSDSPTLDNSRRLPIFSRLSISDD 310 320 330 >>NP_001231630 (OMIM: 601064) zinc finger protein 36, C3 (407 aa) initn: 2302 init1: 2302 opt: 2302 Z-score: 1790.7 bits: 340.0 E(85289): 5.3e-93 Smith-Waterman score: 2302; 100.0% identity (100.0% similar) in 338 aa overlap (1-338:70-407) 10 20 30 pF1KB5 MTTTLVSATIFDLSEVLCKGNKMLNYSAPS :::::::::::::::::::::::::::::: NP_001 GLQTGEAAPSPHRDLRDTPDPRPWLARTHRMTTTLVSATIFDLSEVLCKGNKMLNYSAPS 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB5 AGGCLLDRKAVGTPAGGGFPRRHSVTLPSSKFHQNQLLSSLKGEPAPALSSRDSRFRDRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGGCLLDRKAVGTPAGGGFPRRHSVTLPSSKFHQNQLLSSLKGEPAPALSSRDSRFRDRS 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB5 FSEGGERLLPTQKQPGGGQVNSSRYKTELCRPFEENGACKYGDKCQFAHGIHELRSLTRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSEGGERLLPTQKQPGGGQVNSSRYKTELCRPFEENGACKYGDKCQFAHGIHELRSLTRH 160 170 180 190 200 210 160 170 180 190 200 210 pF1KB5 PKYKTELCRTFHTIGFCPYGPRCHFIHNAEERRALAGARDLSADRPRLQHSFSFAGFPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKYKTELCRTFHTIGFCPYGPRCHFIHNAEERRALAGARDLSADRPRLQHSFSFAGFPSA 220 230 240 250 260 270 220 230 240 250 260 270 pF1KB5 AATAAATGLLDSPTSITPPPILSADDLLGSPTLPDGTNNPFAFSSQELASLFAPSMGLPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AATAAATGLLDSPTSITPPPILSADDLLGSPTLPDGTNNPFAFSSQELASLFAPSMGLPG 280 290 300 310 320 330 280 290 300 310 320 330 pF1KB5 GGSPTTFLFRPMSESPHMFDSPPSPQDSLSDQEGYLSSSSSSHSGSDSPTLDNSRRLPIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGSPTTFLFRPMSESPHMFDSPPSPQDSLSDQEGYLSSSSSSHSGSDSPTLDNSRRLPIF 340 350 360 370 380 390 pF1KB5 SRLSISDD :::::::: NP_001 SRLSISDD 400 >>NP_008818 (OMIM: 612053) zinc finger protein 36, C3H1 (494 aa) initn: 941 init1: 552 opt: 674 Z-score: 534.0 bits: 107.7 E(85289): 5.3e-23 Smith-Waterman score: 737; 49.8% identity (64.2% similar) in 285 aa overlap (11-230:10-290) 10 20 30 40 50 pF1KB5 MTTTLVSATIFDLSEVLCKGNKMLNYSAPSAGGCLLDRKAVGTPAGG--------GFPRR .:. . ::: .: : : . .::.::::::... :: :: NP_008 MSTTLLSAFYDV-DFLCKTEKSL---ANLNLNNMLDKKAVGTPVAAAPSSGFAPGFLRR 10 20 30 40 50 60 70 80 pF1KB5 HSVT--------LPSS-----KF----HQNQLLSSLKGEPA-------P------ALSSR ::.. :: :: . .. :. : :. : :: .. NP_008 HSASNLHALAHPAPSPGSCSPKFPGAANGSSCGSAAAGGPTSYGTLKEPSGGGGTALLNK 60 70 80 90 100 110 90 100 110 120 130 pF1KB5 DSRFRDRSFSEGGER---LLPTQKQP---GGGQVNSSRYKTELCRPFEENGACKYGDKCQ ...::::::::.:.: :: :.: ::.:.::.::::::::::::.:.::::.::: NP_008 ENKFRDRSFSENGDRSQHLLHLQQQQKGGGGSQINSTRYKTELCRPFEESGTCKYGEKCQ 120 130 140 150 160 170 140 150 160 170 180 190 pF1KB5 FAHGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNAEERRAL--AGAR-DLSA ::::.::::::::::::::::::::::::::::::::::::::.::: .:: :: : NP_008 FAHGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNADERRPAPSGGASGDLRA 180 190 200 210 220 230 200 210 220 230 pF1KB5 --------------DRPRLQHSFSFAGFPSA----AATAAATGLLDSPTSITPPPILSAD ::.:.::.::.::::. . . ::::::: :::: NP_008 FGTRDALHLGFPREPRPKLHHSLSFSGFPSGHHQPPGGLESPLLLDSPTSRTPPPPSCSS 240 250 260 270 280 290 240 250 260 270 280 290 pF1KB5 DLLGSPTLPDGTNNPFAFSSQELASLFAPSMGLPGGGSPTTFLFRPMSESPHMFDSPPSP NP_008 ASSCSSSASSCSSASAASTPSGAPTCCASAAAAAAAALLYGTGGAEDLLAPGAPCAACSS 300 310 320 330 340 350 >-- initn: 240 init1: 152 opt: 280 Z-score: 230.2 bits: 51.5 E(85289): 4.4e-06 Smith-Waterman score: 280; 60.2% identity (79.5% similar) in 83 aa overlap (264-338:413-494) 240 250 260 270 280 pF1KB5 ADDLLGSPTLPDGTNNPFAFSSQELASLFAPSMGLPGGGS-----PTTF-LFRPMSESPH :: ::.:.. : .: : : .:.:: NP_008 FAAVAAAAYYRSQQQQQQQGLAPPAQPPAPPSATLPAGAAAPPSPPFSFQLPRRLSDSP- 390 400 410 420 430 440 290 300 310 320 330 pF1KB5 MFDSPPSPQDSLSDQEGYLSSS--SSSHSGSDSPTLDNSRRLPIFSRLSISDD .::.:::: :::::...:::.: :.: :::.::.:: .:::::::::::::: NP_008 VFDAPPSPPDSLSDRDSYLSGSLSSGSLSGSESPSLDPGRRLPIFSRLSISDD 450 460 470 480 490 >>NP_003398 (OMIM: 190700) tristetraprolin [Homo sapiens (332 aa) initn: 494 init1: 377 opt: 509 Z-score: 409.3 bits: 84.1 E(85289): 4.7e-16 Smith-Waterman score: 530; 40.2% identity (56.0% similar) in 266 aa overlap (95-337:90-332) 70 80 90 100 110 120 pF1KB5 NQLLSSLKGEPAPALSSRDSRFRDRSFSEGGERLLPTQKQPGGGQVNSSRYKTELCRPFE : .: :. .: . ... ::::::::: : NP_003 LPGRSTSLVEGRSCGWVPPPPGFAPLAPRLGPELSPSPTSPTATSTTPSRYKTELCRTFS 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB5 ENGACKYGDKCQFAHGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNAEERRA :.: :.:: :::::::. :::. .::::::::::. :. : :::: ::::::: : : NP_003 ESGRCRYGAKCQFAHGLGELRQANRHPKYKTELCHKFYLQGRCPYGSRCHFIHNPSEDLA 120 130 140 150 160 170 190 200 210 220 230 pF1KB5 LAGARDLSADRPRLQHSFSFAGFPSAAATAAAT-GLLD--------SPTSITPPP---IL : : :..:.::.:.::. :. :: ::.: ::: : NP_003 APG------HPPVLRQSISFSGLPSGRRTSPPPPGLAGPSLSSSSFSPSSSPPPPGDLPL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 SADDLLGSPTLPDGTNNPFAFSSQELASLFAPSMGLPGGGSPTTFLFRPMSESPHMFDSP : . . ..: : . .: :. : :: : : NP_003 SPSAFSAAPGTPLARRDPTPVCCPSCRRATPISVWGPLGG-----LVRT----------- 240 250 260 270 300 310 320 330 pF1KB5 PSPQDSLSDQEGYLSSSSSSHSGSDSPTLDNS-----------RRLPIFSRLSISDD :: :. :: . : .::.:: .:::::... . ::::::.:.:.:. NP_003 PSVQSLGSDPDEY-ASSGSSLGGSDSPVFEAGVFAPPQPVAAPRRLPIFNRISVSE 280 290 300 310 320 330 338 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 15:46:35 2016 done: Thu Nov 3 15:46:36 2016 Total Scan time: 7.360 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]