Result of FASTA (omim) for
pF1KB5024
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5024, 428 aa
1>>>pF1KB5024 428 - 428 aa - 428 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.1645+/-0.000577; mu= 9.6524+/- 0.035
mean_var=169.5978+/-33.870, 0's: 0 Z-trim(111.1): 37 B-trim: 435 in 2/52
Lambda= 0.098484
statistics sampled from 19556 (19587) to 19556 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.565), E-opt: 0.2 (0.23), width: 16
Scan time: 8.650
The best scores are: opt bits E(85289)
NP_004466 (OMIM: 131560) flotillin-2 isoform 1 [Ho ( 428) 2688 394.8 2.2e-109
NP_001317099 (OMIM: 131560) flotillin-2 isoform 2 ( 428) 2634 387.1 4.5e-107
XP_016879884 (OMIM: 131560) PREDICTED: flotillin-2 ( 379) 2310 341.1 3e-93
XP_016879883 (OMIM: 131560) PREDICTED: flotillin-2 ( 379) 2310 341.1 3e-93
XP_016879885 (OMIM: 131560) PREDICTED: flotillin-2 ( 379) 2260 334.0 4.1e-91
XP_005258010 (OMIM: 131560) PREDICTED: flotillin-2 ( 351) 2136 316.3 7.8e-86
XP_005248837 (OMIM: 606998) PREDICTED: flotillin-1 ( 427) 1240 189.1 1.9e-47
NP_005794 (OMIM: 606998) flotillin-1 isoform 1 [Ho ( 427) 1240 189.1 1.9e-47
XP_016865646 (OMIM: 606998) PREDICTED: flotillin-1 ( 423) 1178 180.3 8.4e-45
XP_006715010 (OMIM: 606998) PREDICTED: flotillin-1 ( 374) 1061 163.6 7.8e-40
XP_016865647 (OMIM: 606998) PREDICTED: flotillin-1 ( 390) 1058 163.2 1.1e-39
NP_001305804 (OMIM: 606998) flotillin-1 isoform 2 ( 379) 911 142.3 2e-33
>>NP_004466 (OMIM: 131560) flotillin-2 isoform 1 [Homo s (428 aa)
initn: 2688 init1: 2688 opt: 2688 Z-score: 2084.8 bits: 394.8 E(85289): 2.2e-109
Smith-Waterman score: 2688; 100.0% identity (100.0% similar) in 428 aa overlap (1-428:1-428)
10 20 30 40 50 60
pF1KB5 MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 TAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 EQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDAD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 IGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 YELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 AEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 LEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLI
370 380 390 400 410 420
pF1KB5 KKATGVQV
::::::::
NP_004 KKATGVQV
>>NP_001317099 (OMIM: 131560) flotillin-2 isoform 2 [Hom (428 aa)
initn: 2634 init1: 2634 opt: 2634 Z-score: 2043.3 bits: 387.1 E(85289): 4.5e-107
Smith-Waterman score: 2634; 97.7% identity (99.1% similar) in 428 aa overlap (1-428:1-428)
10 20 30 40 50 60
pF1KB5 MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVE
::::::::::::::::::::::::::::::::::::::::::::.:::.::. :::..:
NP_001 MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRLSLEVMTILCRCENIE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 TAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTV
:.::: : ::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSEGVPLFVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 EQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDAD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 IGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 YELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 AEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 LEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLI
370 380 390 400 410 420
pF1KB5 KKATGVQV
::::::::
NP_001 KKATGVQV
>>XP_016879884 (OMIM: 131560) PREDICTED: flotillin-2 iso (379 aa)
initn: 2310 init1: 2310 opt: 2310 Z-score: 1795.2 bits: 341.1 E(85289): 3e-93
Smith-Waterman score: 2310; 100.0% identity (100.0% similar) in 379 aa overlap (50-428:1-379)
20 30 40 50 60 70
pF1KB5 CGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVETAEGVALTVTGVAQVKIMT
::::::::::::::::::::::::::::::
XP_016 MTLQPRCEDVETAEGVALTVTGVAQVKIMT
10 20 30
80 90 100 110 120 130
pF1KB5 EKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAA
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB5 PDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKK
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB5 EMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB5 EVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKI
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB5 RKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVD
280 290 300 310 320 330
380 390 400 410 420
pF1KB5 EIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLIKKATGVQV
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLIKKATGVQV
340 350 360 370
>>XP_016879883 (OMIM: 131560) PREDICTED: flotillin-2 iso (379 aa)
initn: 2310 init1: 2310 opt: 2310 Z-score: 1795.2 bits: 341.1 E(85289): 3e-93
Smith-Waterman score: 2310; 100.0% identity (100.0% similar) in 379 aa overlap (50-428:1-379)
20 30 40 50 60 70
pF1KB5 CGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVETAEGVALTVTGVAQVKIMT
::::::::::::::::::::::::::::::
XP_016 MTLQPRCEDVETAEGVALTVTGVAQVKIMT
10 20 30
80 90 100 110 120 130
pF1KB5 EKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAA
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB5 PDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKK
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB5 EMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB5 EVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKI
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB5 RKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVD
280 290 300 310 320 330
380 390 400 410 420
pF1KB5 EIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLIKKATGVQV
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLIKKATGVQV
340 350 360 370
>>XP_016879885 (OMIM: 131560) PREDICTED: flotillin-2 iso (379 aa)
initn: 2260 init1: 2260 opt: 2260 Z-score: 1756.8 bits: 334.0 E(85289): 4.1e-91
Smith-Waterman score: 2260; 97.9% identity (98.9% similar) in 379 aa overlap (50-428:1-379)
20 30 40 50 60 70
pF1KB5 CGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVETAEGVALTVTGVAQVKIMT
::. :::..::.::: : :::::::::::
XP_016 MTILCRCENIETSEGVPLFVTGVAQVKIMT
10 20 30
80 90 100 110 120 130
pF1KB5 EKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAA
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB5 PDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKK
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB5 EMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB5 EVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKI
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB5 RKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVD
280 290 300 310 320 330
380 390 400 410 420
pF1KB5 EIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLIKKATGVQV
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLIKKATGVQV
340 350 360 370
>>XP_005258010 (OMIM: 131560) PREDICTED: flotillin-2 iso (351 aa)
initn: 2136 init1: 2136 opt: 2136 Z-score: 1662.0 bits: 316.3 E(85289): 7.8e-86
Smith-Waterman score: 2136; 100.0% identity (100.0% similar) in 351 aa overlap (78-428:1-351)
50 60 70 80 90 100
pF1KB5 EIMTLQPRCEDVETAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTL
::::::::::::::::::::::::::::::
XP_005 MTEKELLAVACEQFLGKNVQDIKNVVLQTL
10 20 30
110 120 130 140 150 160
pF1KB5 EGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSL
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB5 GKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFS
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB5 EEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVR
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB5 RPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEA
220 230 240 250 260 270
350 360 370 380 390 400
pF1KB5 YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVH
280 290 300 310 320 330
410 420
pF1KB5 ALTGVDLSKIPLIKKATGVQV
:::::::::::::::::::::
XP_005 ALTGVDLSKIPLIKKATGVQV
340 350
>>XP_005248837 (OMIM: 606998) PREDICTED: flotillin-1 iso (427 aa)
initn: 1406 init1: 987 opt: 1240 Z-score: 972.9 bits: 189.1 E(85289): 1.9e-47
Smith-Waterman score: 1240; 47.6% identity (80.4% similar) in 418 aa overlap (6-417:4-419)
10 20 30 40 50 60
pF1KB5 MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVE
: :::::.:::: : . .: :: ... ::.. :::::. .::. . : :
XP_005 MFFTCGPNEAMVVSGFCRSPPV--MVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVY
10 20 30 40 50
70 80 90 100 110
pF1KB5 TAEGVALTVTGVAQVKIMTE-KELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLT
: .:: ..:::.:::::. . ::.::.::..::::. .: ...:.::::: :.:.. .:
XP_005 TRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 VEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDA
::.::.::..:.. : .::. :. ::: ..:.:.::..: ::: ::::..:: ::.::
XP_005 VEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 DIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL
:: :::.::::::::. :.: ........ ..: ..: .::.:.:.. ::: . :.:.:
XP_005 RIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB5 AYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQ
::.:: :. .:.:........::.: .:.::. ::: : .::: : ::.::::: .....
XP_005 AYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLER
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB5 IAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMAL
.::.:: . .. :.::: ..: ::::: .: : ..::::.: ::::.: : .::.. .
XP_005 LAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDM
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB5 VLEALPQIAAKIAAPLTKVDEIVVLSGDN-----SKVTSEVNRLLAELPASVHALTGVDL
.:: :::.: .:..:::....:...:. . .:::.:: .:..:: ::. ::::..
XP_005 LLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSI
360 370 380 390 400 410
420
pF1KB5 SKIPLIKKATGVQV
:..
XP_005 SQVNHKPLRTA
420
>>NP_005794 (OMIM: 606998) flotillin-1 isoform 1 [Homo s (427 aa)
initn: 1406 init1: 987 opt: 1240 Z-score: 972.9 bits: 189.1 E(85289): 1.9e-47
Smith-Waterman score: 1240; 47.6% identity (80.4% similar) in 418 aa overlap (6-417:4-419)
10 20 30 40 50 60
pF1KB5 MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVE
: :::::.:::: : . .: :: ... ::.. :::::. .::. . : :
NP_005 MFFTCGPNEAMVVSGFCRSPPV--MVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVY
10 20 30 40 50
70 80 90 100 110
pF1KB5 TAEGVALTVTGVAQVKIMTE-KELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLT
: .:: ..:::.:::::. . ::.::.::..::::. .: ...:.::::: :.:.. .:
NP_005 TRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 VEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDA
::.::.::..:.. : .::. :. ::: ..:.:.::..: ::: ::::..:: ::.::
NP_005 VEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 DIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL
:: :::.::::::::. :.: ........ ..: ..: .::.:.:.. ::: . :.:.:
NP_005 RIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB5 AYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQ
::.:: :. .:.:........::.: .:.::. ::: : .::: : ::.::::: .....
NP_005 AYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLER
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB5 IAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMAL
.::.:: . .. :.::: ..: ::::: .: : ..::::.: ::::.: : .::.. .
NP_005 LAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDM
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB5 VLEALPQIAAKIAAPLTKVDEIVVLSGDN-----SKVTSEVNRLLAELPASVHALTGVDL
.:: :::.: .:..:::....:...:. . .:::.:: .:..:: ::. ::::..
NP_005 LLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSI
360 370 380 390 400 410
420
pF1KB5 SKIPLIKKATGVQV
:..
NP_005 SQVNHKPLRTA
420
>>XP_016865646 (OMIM: 606998) PREDICTED: flotillin-1 iso (423 aa)
initn: 1324 init1: 987 opt: 1178 Z-score: 925.3 bits: 180.3 E(85289): 8.4e-45
Smith-Waterman score: 1178; 47.9% identity (81.2% similar) in 388 aa overlap (36-417:30-415)
10 20 30 40 50 60
pF1KB5 TVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVETAEGV
:: : :::::. .::. . : : : .::
XP_016 MEPGAAEKQGERGKLQPEPCFSLVAQMRPWW--SPIQRISLNTLTLNVKSEKVYTRHGV
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 ALTVTGVAQVKIMTE-KELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTVEQIY
..:::.:::::. . ::.::.::..::::. .: ...:.::::: :.:.. .:::.::
XP_016 PISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIY
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB5 QDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVA
.::..:.. : .::. :. ::: ..:.:.::..: ::: ::::..:: ::.:: :: :
XP_016 KDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEA
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB5 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ
::.::::::::. :.: ........ ..: ..: .::.:.:.. ::: . :.:.:::.::
XP_016 EAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQ
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB5 GAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGE
:. .:.:........::.: .:.::. ::: : .::: : ::.::::: ......::.:
XP_016 VAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAE
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB5 KVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEAL
: . .. :.::: ..: ::::: .: : ..::::.: ::::.: : .::.. ..:: :
XP_016 KSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKL
300 310 320 330 340 350
370 380 390 400 410
pF1KB5 PQIAAKIAAPLTKVDEIVVLSGDN-----SKVTSEVNRLLAELPASVHALTGVDLSKIPL
::.: .:..:::....:...:. . .:::.:: .:..:: ::. ::::..:..
XP_016 PQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVNH
360 370 380 390 400 410
420
pF1KB5 IKKATGVQV
XP_016 KPLRTA
420
>>XP_006715010 (OMIM: 606998) PREDICTED: flotillin-1 iso (374 aa)
initn: 1257 init1: 987 opt: 1061 Z-score: 836.2 bits: 163.6 E(85289): 7.8e-40
Smith-Waterman score: 1061; 46.9% identity (81.8% similar) in 358 aa overlap (66-417:10-366)
40 50 60 70 80 90
pF1KB5 WWCISDTQRISLEIMTLQPRCEDVETAEGVALTVTGVAQVKIMTE-KELLAVACEQFLGK
:..:. .:::. . ::.::.::..::::
XP_006 MFFTCGPNEAMVVSD-PEVKIQGQNKEMLAAACQMFLGK
10 20 30
100 110 120 130 140 150
pF1KB5 NVQDIKNVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTI
. .: ...:.::::: :.:.. .:::.::.::..:.. : .::. :. ::: ..:.:.
XP_006 TEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTL
40 50 60 70 80 90
160 170 180 190 200 210
pF1KB5 KDVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIAD
::..: ::: ::::..:: ::.:: :: :::.::::::::. :.: ........ ..:
XP_006 KDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQYLSEIEMAK
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB5 SKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQE
..: .::.:.:.. ::: . :.:.:::.:: :. .:.:........::.: .:.::. ::
XP_006 AQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQE
160 170 180 190 200 210
280 290 300 310 320 330
pF1KB5 ILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMG
: : .::: : ::.::::: ......::.:: . .. :.::: ..: ::::: .: : .
XP_006 IARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEAEAFAIGARA
220 230 240 250 260 270
340 350 360 370 380
pF1KB5 KAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDN-----S
.::::.: ::::.: : .::.. ..:: :::.: .:..:::....:...:. . .
XP_006 RAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAA
280 290 300 310 320 330
390 400 410 420
pF1KB5 KVTSEVNRLLAELPASVHALTGVDLSKIPLIKKATGVQV
:::.:: .:..:: ::. ::::..:..
XP_006 KVTGEVLDILTRLPESVERLTGVSISQVNHKPLRTA
340 350 360 370
428 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 12:21:10 2016 done: Sat Nov 5 12:21:11 2016
Total Scan time: 8.650 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]