FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5046, 396 aa 1>>>pF1KB5046 396 - 396 aa - 396 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2147+/-0.000341; mu= 17.1746+/- 0.021 mean_var=61.4141+/-12.338, 0's: 0 Z-trim(113.8): 21 B-trim: 0 in 0/55 Lambda= 0.163659 statistics sampled from 23253 (23274) to 23253 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.646), E-opt: 0.2 (0.273), width: 16 Scan time: 8.810 The best scores are: opt bits E(85289) NP_001107657 (OMIM: 175900,251170,260920,610377) m ( 396) 2593 620.8 1.8e-177 XP_016874803 (OMIM: 175900,251170,260920,610377) P ( 396) 2593 620.8 1.8e-177 NP_000422 (OMIM: 175900,251170,260920,610377) meva ( 396) 2593 620.8 1.8e-177 XP_011536674 (OMIM: 175900,251170,260920,610377) P ( 496) 2593 620.8 2.2e-177 XP_016874802 (OMIM: 175900,251170,260920,610377) P ( 344) 1460 353.2 5.4e-97 NP_001288111 (OMIM: 175900,251170,260920,610377) m ( 344) 1460 353.2 5.4e-97 >>NP_001107657 (OMIM: 175900,251170,260920,610377) meval (396 aa) initn: 2593 init1: 2593 opt: 2593 Z-score: 3307.2 bits: 620.8 E(85289): 1.8e-177 Smith-Waterman score: 2593; 99.7% identity (100.0% similar) in 396 aa overlap (1-396:1-396) 10 20 30 40 50 60 pF1KB5 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLNLPNIGIKR :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: NP_001 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 310 320 330 340 350 360 370 380 390 pF1KB5 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL :::::::::::::::::::::::::::::::::::: NP_001 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 370 380 390 >>XP_016874803 (OMIM: 175900,251170,260920,610377) PREDI (396 aa) initn: 2593 init1: 2593 opt: 2593 Z-score: 3307.2 bits: 620.8 E(85289): 1.8e-177 Smith-Waterman score: 2593; 99.7% identity (100.0% similar) in 396 aa overlap (1-396:1-396) 10 20 30 40 50 60 pF1KB5 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLNLPNIGIKR :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: XP_016 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 310 320 330 340 350 360 370 380 390 pF1KB5 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL :::::::::::::::::::::::::::::::::::: XP_016 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 370 380 390 >>NP_000422 (OMIM: 175900,251170,260920,610377) mevalona (396 aa) initn: 2593 init1: 2593 opt: 2593 Z-score: 3307.2 bits: 620.8 E(85289): 1.8e-177 Smith-Waterman score: 2593; 99.7% identity (100.0% similar) in 396 aa overlap (1-396:1-396) 10 20 30 40 50 60 pF1KB5 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLNLPNIGIKR :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: NP_000 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 310 320 330 340 350 360 370 380 390 pF1KB5 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL :::::::::::::::::::::::::::::::::::: NP_000 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 370 380 390 >>XP_011536674 (OMIM: 175900,251170,260920,610377) PREDI (496 aa) initn: 2593 init1: 2593 opt: 2593 Z-score: 3305.7 bits: 620.8 E(85289): 2.2e-177 Smith-Waterman score: 2593; 99.7% identity (100.0% similar) in 396 aa overlap (1-396:101-496) 10 20 30 pF1KB5 MLSEVLLVSAPGKVILHGEHAVVHGKVALA :::::::::::::::::::::::::::::: XP_011 TGPDPARFPSSPRGDSTHSWPRHRSGFPGAMLSEVLLVSAPGKVILHGEHAVVHGKVALA 80 90 100 110 120 130 40 50 60 70 80 90 pF1KB5 VSLNLRTFLRLQPHSNGKVDLNLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEK :::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::: XP_011 VSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEK 140 150 160 170 180 190 100 110 120 130 140 150 pF1KB5 LKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYS 200 210 220 230 240 250 160 170 180 190 200 210 pF1KB5 VCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTW 260 270 280 290 300 310 220 230 240 250 260 270 pF1KB5 GGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDA 320 330 340 350 360 370 280 290 300 310 320 330 pF1KB5 ISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSK 380 390 400 410 420 430 340 350 360 370 380 390 pF1KB5 LTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQ 440 450 460 470 480 490 pF1KB5 QALDGL :::::: XP_011 QALDGL >>XP_016874802 (OMIM: 175900,251170,260920,610377) PREDI (344 aa) initn: 1460 init1: 1460 opt: 1460 Z-score: 1862.4 bits: 353.2 E(85289): 5.4e-97 Smith-Waterman score: 2126; 86.6% identity (86.9% similar) in 396 aa overlap (1-396:1-344) 10 20 30 40 50 60 pF1KB5 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLNLPNIGIKR :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: XP_016 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE :::: :::: XP_016 RKQR----------------------------------------------------WTKE 190 200 210 220 230 240 pF1KB5 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 130 140 150 160 170 180 250 260 270 280 290 300 pF1KB5 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 190 200 210 220 230 240 310 320 330 340 350 360 pF1KB5 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 250 260 270 280 290 300 370 380 390 pF1KB5 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL :::::::::::::::::::::::::::::::::::: XP_016 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 310 320 330 340 >>NP_001288111 (OMIM: 175900,251170,260920,610377) meval (344 aa) initn: 1460 init1: 1460 opt: 1460 Z-score: 1862.4 bits: 353.2 E(85289): 5.4e-97 Smith-Waterman score: 2126; 86.6% identity (86.9% similar) in 396 aa overlap (1-396:1-344) 10 20 30 40 50 60 pF1KB5 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLNLPNIGIKR :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: NP_001 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKE :::: :::: NP_001 RKQR----------------------------------------------------WTKE 190 200 210 220 230 240 pF1KB5 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVP 130 140 150 160 170 180 250 260 270 280 290 300 pF1KB5 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDM 190 200 210 220 230 240 310 320 330 340 350 360 pF1KB5 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQAL 250 260 270 280 290 300 370 380 390 pF1KB5 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL :::::::::::::::::::::::::::::::::::: NP_001 TSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL 310 320 330 340 396 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 03:21:47 2016 done: Fri Nov 4 03:21:48 2016 Total Scan time: 8.810 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]