FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5060, 585 aa 1>>>pF1KB5060 585 - 585 aa - 585 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3796+/-0.00042; mu= 18.3629+/- 0.026 mean_var=74.3114+/-15.070, 0's: 0 Z-trim(111.1): 108 B-trim: 192 in 1/50 Lambda= 0.148781 statistics sampled from 19516 (19639) to 19516 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.593), E-opt: 0.2 (0.23), width: 16 Scan time: 8.900 The best scores are: opt bits E(85289) NP_005558 (OMIM: 600626) galectin-3-binding protei ( 585) 3985 865.4 0 XP_011537696 (OMIM: 601969) PREDICTED: deleted in (2532) 476 112.6 1.6e-23 XP_011537697 (OMIM: 601969) PREDICTED: deleted in (2532) 476 112.6 1.6e-23 XP_011537695 (OMIM: 601969) PREDICTED: deleted in (2532) 470 111.3 3.8e-23 XP_011537692 (OMIM: 601969) PREDICTED: deleted in (2532) 469 111.1 4.5e-23 NP_981961 (OMIM: 605545) scavenger receptor cystei (1121) 462 109.4 6.6e-23 XP_005253586 (OMIM: 605545) PREDICTED: scavenger r (1124) 462 109.4 6.6e-23 NP_004235 (OMIM: 605545) scavenger receptor cystei (1156) 462 109.4 6.7e-23 XP_016875720 (OMIM: 605545) PREDICTED: scavenger r (1161) 462 109.4 6.8e-23 NP_060049 (OMIM: 601969) deleted in malignant brai (2403) 463 109.8 1e-22 XP_011537693 (OMIM: 601969) PREDICTED: deleted in (2532) 463 109.8 1.1e-22 XP_011537711 (OMIM: 601969) PREDICTED: deleted in (2411) 460 109.2 1.6e-22 XP_011537717 (OMIM: 601969) PREDICTED: deleted in (1766) 452 107.4 4.2e-22 XP_011537716 (OMIM: 601969) PREDICTED: deleted in (1783) 452 107.4 4.2e-22 NP_004397 (OMIM: 601969) deleted in malignant brai (1785) 452 107.4 4.2e-22 XP_016871287 (OMIM: 601969) PREDICTED: deleted in (1990) 452 107.4 4.6e-22 XP_011537715 (OMIM: 601969) PREDICTED: deleted in (2282) 452 107.4 5.1e-22 XP_011537713 (OMIM: 601969) PREDICTED: deleted in (2403) 452 107.5 5.4e-22 XP_011537712 (OMIM: 601969) PREDICTED: deleted in (2411) 452 107.5 5.4e-22 XP_011537710 (OMIM: 601969) PREDICTED: deleted in (2411) 452 107.5 5.4e-22 XP_011537709 (OMIM: 601969) PREDICTED: deleted in (2411) 452 107.5 5.4e-22 NP_001307573 (OMIM: 601969) deleted in malignant b (2412) 452 107.5 5.4e-22 NP_015568 (OMIM: 601969) deleted in malignant brai (2413) 452 107.5 5.4e-22 XP_011537704 (OMIM: 601969) PREDICTED: deleted in (2413) 452 107.5 5.4e-22 XP_011537707 (OMIM: 601969) PREDICTED: deleted in (2413) 452 107.5 5.4e-22 XP_011537703 (OMIM: 601969) PREDICTED: deleted in (2413) 452 107.5 5.4e-22 XP_011537705 (OMIM: 601969) PREDICTED: deleted in (2413) 452 107.5 5.4e-22 XP_011537702 (OMIM: 601969) PREDICTED: deleted in (2434) 452 107.5 5.4e-22 XP_006717728 (OMIM: 601969) PREDICTED: deleted in (2510) 452 107.5 5.5e-22 XP_011537701 (OMIM: 601969) PREDICTED: deleted in (2510) 452 107.5 5.5e-22 XP_011537700 (OMIM: 601969) PREDICTED: deleted in (2521) 452 107.5 5.6e-22 XP_006717723 (OMIM: 601969) PREDICTED: deleted in (2526) 452 107.5 5.6e-22 XP_011537698 (OMIM: 601969) PREDICTED: deleted in (2526) 452 107.5 5.6e-22 XP_011537694 (OMIM: 601969) PREDICTED: deleted in (2532) 452 107.5 5.6e-22 XP_011537691 (OMIM: 601969) PREDICTED: deleted in (2541) 452 107.5 5.6e-22 XP_011537690 (OMIM: 601969) PREDICTED: deleted in (2542) 452 107.5 5.6e-22 XP_005263375 (OMIM: 249500,606709) PREDICTED: neur ( 555) 422 100.6 1.4e-20 XP_011530689 (OMIM: 249500,606709) PREDICTED: neur ( 573) 422 100.6 1.5e-20 NP_003610 (OMIM: 249500,606709) neurotrypsin precu ( 875) 422 100.7 2.1e-20 XP_011518923 (OMIM: 606079) PREDICTED: scavenger r ( 766) 413 98.8 7.1e-20 XP_011518921 (OMIM: 606079) PREDICTED: scavenger r (1182) 413 98.9 1e-19 XP_011518922 (OMIM: 606079) PREDICTED: scavenger r (1182) 413 98.9 1e-19 XP_011518920 (OMIM: 606079) PREDICTED: scavenger r (1214) 413 98.9 1e-19 XP_011518918 (OMIM: 606079) PREDICTED: scavenger r (1421) 413 98.9 1.2e-19 XP_011518919 (OMIM: 606079) PREDICTED: scavenger r (1428) 413 98.9 1.2e-19 NP_777601 (OMIM: 606079) scavenger receptor cystei (1453) 413 98.9 1.2e-19 NP_001284579 (OMIM: 606079) scavenger receptor cys (1463) 413 98.9 1.2e-19 XP_016867239 (OMIM: 607639) PREDICTED: scavenger r ( 406) 394 94.5 7.2e-19 NP_542782 (OMIM: 607639) scavenger receptor cystei ( 575) 394 94.6 9.5e-19 XP_005270273 (OMIM: 607318) PREDICTED: lysyl oxida ( 757) 376 90.8 1.7e-17 >>NP_005558 (OMIM: 600626) galectin-3-binding protein pr (585 aa) initn: 3985 init1: 3985 opt: 3985 Z-score: 4623.1 bits: 865.4 E(85289): 0 Smith-Waterman score: 3985; 100.0% identity (100.0% similar) in 585 aa overlap (1-585:1-585) 10 20 30 40 50 60 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 VCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 VVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILTANL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILTANL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 EAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKLASAYGARQLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKLASAYGARQLQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GYCASLFAILLPQDPSFQMPLDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GYCASLFAILLPQDPSFQMPLDLYAYAVATGDALLEKLCLQFLAWNFEALTQAEAWPSVP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 TDLLQLLLPRSDLAVPSELALLKAVDTWSWGERASHEEVEGLVEKIRFPMMLPEELFELQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TDLLQLLLPRSDLAVPSELALLKAVDTWSWGERASHEEVEGLVEKIRFPMMLPEELFELQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 FNLSLYWSHEALFQKKTLQALEFHTVPFQLLARYKGLNLTEDTYKPRIYTSPTWSAFVTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FNLSLYWSHEALFQKKTLQALEFHTVPFQLLARYKGLNLTEDTYKPRIYTSPTWSAFVTD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 SSWSARKSQLVYQSRRGPLVKYSSDYFQAPSDYRYYPYQSFQTPQHPSFLFQDKRVSWSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SSWSARKSQLVYQSRRGPLVKYSSDYFQAPSDYRYYPYQSFQTPQHPSFLFQDKRVSWSL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 VYLPTIQSCWNYGFSCSSDELPVLGLTKSGGSDRTIAYENKALMLCEGLFVADVTDFEGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VYLPTIQSCWNYGFSCSSDELPVLGLTKSGGSDRTIAYENKALMLCEGLFVADVTDFEGW 490 500 510 520 530 540 550 560 570 580 pF1KB5 KAAIPSALDTNSSKSTSSFPCPAGHFNGFRTVIRPFYLTNSSGVD ::::::::::::::::::::::::::::::::::::::::::::: NP_005 KAAIPSALDTNSSKSTSSFPCPAGHFNGFRTVIRPFYLTNSSGVD 550 560 570 580 >>XP_011537696 (OMIM: 601969) PREDICTED: deleted in mali (2532 aa) initn: 467 init1: 467 opt: 476 Z-score: 543.4 bits: 112.6 E(85289): 1.6e-23 Smith-Waterman score: 476; 47.7% identity (71.5% similar) in 151 aa overlap (14-163:1240-1389) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYR :.: : ... .::..:: :::::..:: XP_011 NCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYR 1210 1220 1230 1240 1250 1260 50 60 70 80 90 100 pF1KB5 GQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLAD :.::::::. :: .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : . XP_011 GSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1270 1280 1290 1300 1310 1320 110 120 130 140 150 160 pF1KB5 CKSLGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQ : :::. :: :..::::.:.. ..:. . : : :: . ..: :. . : . XP_011 CPHNGWLSHNCGHHEDAGVICSDTWPTSHASTAGSESSLALRLVNGGDR-CQGRVEVLYR 1330 1340 1350 1360 1370 1380 170 180 190 200 210 220 pF1KB5 GEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLS : XP_011 GSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1390 1400 1410 1420 1430 1440 >-- initn: 1720 init1: 452 opt: 452 Z-score: 515.6 bits: 107.5 E(85289): 5.6e-22 Smith-Waterman score: 452; 59.4% identity (80.2% similar) in 101 aa overlap (24-124:862-962) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: :::::..:::.::::::. : XP_011 CSVSQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSW 840 850 860 870 880 890 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: :::. :: XP_011 DTSDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNC 900 910 920 930 940 950 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHT .: .::::.:. XP_011 QHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNGGDRCQGRVEVLYQ 960 970 980 990 1000 1010 >-- initn: 868 init1: 452 opt: 452 Z-score: 515.6 bits: 107.5 E(85289): 5.6e-22 Smith-Waterman score: 458; 57.1% identity (78.6% similar) in 112 aa overlap (24-134:602-713) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: :::::..:::.::::::. : XP_011 SCPHNGWLSHNCGHSEDAGVICSGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSW 580 590 600 610 620 630 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: . :::. :: XP_011 DTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPNNGWLSHNC 640 650 660 670 680 690 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTN-ETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH :..::::.:. ..::: : XP_011 GHHEDAGVICSAAQSRSTPRPDTLSTITLPPSTVGSESSLTLRLVNGSDRCQGRVEVLYR 700 710 720 730 740 750 >-- initn: 1296 init1: 452 opt: 452 Z-score: 515.6 bits: 107.5 E(85289): 5.6e-22 Smith-Waterman score: 452; 59.4% identity (80.2% similar) in 101 aa overlap (24-124:363-463) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: :::::..:::.::::::. : XP_011 CSAPQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSW 340 350 360 370 380 390 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: :::. :: XP_011 DTSDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNC 400 410 420 430 440 450 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHT .: .::::.:. XP_011 QHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNGGDRCQGRVEVLYR 460 470 480 490 500 510 >-- initn: 492 init1: 449 opt: 452 Z-score: 515.6 bits: 107.5 E(85289): 5.6e-22 Smith-Waterman score: 452; 52.8% identity (77.2% similar) in 123 aa overlap (14-134:1488-1610) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYR :.: : ... .::..:: :::::..:: XP_011 NCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYR 1460 1470 1480 1490 1500 1510 50 60 70 80 90 100 pF1KB5 GQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLAD :.::::::. :: .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : . XP_011 GSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1520 1530 1540 1550 1560 1570 110 120 130 140 150 160 pF1KB5 CKSLGWLKSNCRHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNV : :::. :: :..::::.:. .... : . : XP_011 CPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSRASTAGSESTLALRLVNGGDRC 1580 1590 1600 1610 1620 1630 170 180 190 200 210 220 pF1KB5 QGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITL XP_011 RGRVEVLYQGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQFGQGSGPIVLDDVRC 1640 1650 1660 1670 1680 1690 >-- initn: 472 init1: 436 opt: 447 Z-score: 509.8 bits: 106.4 E(85289): 1.2e-21 Smith-Waterman score: 447; 55.4% identity (78.6% similar) in 112 aa overlap (24-134:733-844) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:. :::::..:::.::::::. : XP_011 AAQSRSTPRPDTLSTITLPPSTVGSESSLTLRLVNGSDRCQGRVEVLYRGSWGTVCDDSW 710 720 730 740 750 760 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: :::. :: XP_011 DTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNC 770 780 790 800 810 820 120 130 140 150 160 170 pF1KB5 RHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH :..::::.:. ...: : . : XP_011 GHHEDAGVICSVSQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGS 830 840 850 860 870 880 >-- initn: 474 init1: 439 opt: 446 Z-score: 508.6 bits: 106.2 E(85289): 1.4e-21 Smith-Waterman score: 446; 51.5% identity (72.3% similar) in 130 aa overlap (2-129:470-599) 10 20 pF1KB5 MTP-PRLFWVWLLVAGTQGVNDG-DMRLADG :: : . . : :.: : ... .::..: XP_011 WSCPHNGWLSHNCQHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNG 440 450 460 470 480 490 30 40 50 60 70 80 pF1KB5 GATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLD : :::::..:::.::::::. :: .::.:::: :: : : : : ::::::::.:: XP_011 GDRCQGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMLAPGNARFGQGSGPIVLD 500 510 520 530 540 550 90 100 110 120 130 140 pF1KB5 EVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDS .:.:.:.:. : .: :::. :: : .::::.:.. : XP_011 DVRCSGNESYLWSCPHNGWLSHNCGHSEDAGVICSGPESSLALRLVNGGDRCQGRVEVLY 560 570 580 590 600 610 150 160 170 180 190 200 pF1KB5 QRGCDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLL XP_011 RGSWGTVCDDSWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLW 620 630 640 650 660 670 >-- initn: 909 init1: 443 opt: 446 Z-score: 508.6 bits: 106.2 E(85289): 1.4e-21 Smith-Waterman score: 446; 52.0% identity (76.4% similar) in 123 aa overlap (14-134:1111-1233) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYR :.: : ... .::..:: :::::..:: XP_011 NCGHSEDAGVICSASQSRPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYR 1090 1100 1110 1120 1130 1140 50 60 70 80 90 100 pF1KB5 GQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLAD :.::::::. :: .::.:::: :: : .: : : ::::::::.::.:.:.: :. : . XP_011 GSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1150 1160 1170 1180 1190 1200 110 120 130 140 150 160 pF1KB5 CKSLGWLKSNCRHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNV : :::. :: :..::::.:. .... : . : XP_011 CPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRC 1210 1220 1230 1240 1250 1260 170 180 190 200 210 220 pF1KB5 QGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITL XP_011 QGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRC 1270 1280 1290 1300 1310 1320 >-- initn: 480 init1: 431 opt: 446 Z-score: 508.6 bits: 106.2 E(85289): 1.4e-21 Smith-Waterman score: 446; 50.0% identity (72.8% similar) in 136 aa overlap (2-134:969-1104) 10 20 pF1KB5 MTP-PRLFWVWLLVAGTQGVNDG-DMRLADG :: : . . : :.: : ... .::..: XP_011 WSCPHNGWLSHNCQHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNG 940 950 960 970 980 990 30 40 50 60 70 80 pF1KB5 GATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLD : :::::..:.:.::::::. :: .::.:::: :: : .: : : ::::::::.:: XP_011 GDRCQGRVEVLYQGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLD 1000 1010 1020 1030 1040 1050 90 100 110 120 130 140 pF1KB5 EVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFD .:.:.: :. : .: :::. :: : .::::.:. ...: : . : XP_011 DVRCSGHESYLWSCPHNGWLSHNCGHSEDAGVICSASQSRPTPSPDTWPTSHASTAGSES 1060 1070 1080 1090 1100 1110 150 160 170 180 190 200 pF1KB5 SQRGCDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDL XP_011 SLALRLVNGGDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNARFG 1120 1130 1140 1150 1160 1170 >-- initn: 486 init1: 443 opt: 444 Z-score: 506.3 bits: 105.8 E(85289): 1.8e-21 Smith-Waterman score: 444; 51.2% identity (72.1% similar) in 129 aa overlap (10-134:1741-1869) 10 20 30 pF1KB5 MTPPRLFWVWL---LVAGTQGVNDG-DMRLADGGATNQG :: : : : : ... .::..:: .: XP_011 GWLSHNCGHHEDAGVICSAAQSQSTPRPDTWLTTNLPALTVGSESSLALRLVNGGDRCRG 1720 1730 1740 1750 1760 1770 40 50 60 70 80 90 pF1KB5 RVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTG :::..:::.::::::. :: .::.:::: :: : .: : : ::::::::.::.:.:.: XP_011 RVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSG 1780 1790 1800 1810 1820 1830 100 110 120 130 140 150 pF1KB5 TEASLADCKSLGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDL .:. : .: ::: :: :..::::.:. .. : : XP_011 NESYLWSCPHKGWLTHNCGHHEDAGVICSATQINSTTTDWWHPTTTTTARPSSNCGGFLF 1840 1850 1860 1870 1880 1890 160 170 180 190 200 210 pF1KB5 SISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSR XP_011 YASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSL 1900 1910 1920 1930 1940 1950 >-- initn: 469 init1: 433 opt: 442 Z-score: 504.0 bits: 105.3 E(85289): 2.5e-21 Smith-Waterman score: 442; 54.5% identity (75.0% similar) in 112 aa overlap (24-134:234-345) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: .::::..:::.::::::. : XP_011 AQPQSTLRPESWPVRISPPVPTEGSESSLALRLVNGGDRCRGRVEVLYRGSWGTVCDDYW 210 220 230 240 250 260 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: : .: : : ::::::::.::.:.:.: :. : .: ::: :: XP_011 DTNDANVVCRQLGCGWAMSAPGNAQFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLTHNC 270 280 290 300 310 320 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTN-ETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH : .::::.:. ..: : . : XP_011 GHSEDAGVICSAPQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGS 330 340 350 360 370 380 >-- initn: 461 init1: 429 opt: 435 Z-score: 495.9 bits: 103.8 E(85289): 7e-21 Smith-Waterman score: 435; 53.6% identity (76.8% similar) in 112 aa overlap (24-134:1628-1739) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: .::::..:.:.::::::. : XP_011 CSASQSQPTPSPDTWPTSRASTAGSESTLALRLVNGGDRCRGRVEVLYQGSWGTVCDDYW 1600 1610 1620 1630 1640 1650 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: : .: : : ::::::::.::.:.:.: :. : .: :::. :: XP_011 DTNDANVVCRQLGCGWAMSAPGNAQFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNC 1660 1670 1680 1690 1700 1710 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTN-ETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH :..::::.:. ...:: : XP_011 GHHEDAGVICSAAQSQSTPRPDTWLTTNLPALTVGSESSLALRLVNGGDRCRGRVEVLYR 1720 1730 1740 1750 1760 1770 >-- initn: 467 init1: 426 opt: 433 Z-score: 493.5 bits: 103.4 E(85289): 9.4e-21 Smith-Waterman score: 433; 56.0% identity (76.1% similar) in 109 aa overlap (17-124:94-202) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYRGQW .: ..: .::..: . ::::::.:::.: XP_011 SPISLESTLESTVAEGSLIPSESTLESTVAEGSDSGLALRLVNGDGRCQGRVEILYRGSW 70 80 90 100 110 120 50 60 70 80 90 100 pF1KB5 GTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKS :::::. :: .::.:::: :: : .: : : :::::::: ::.:.:.: :. : .: XP_011 GTVCDDSWDTNDANVVCRQLGCGWAMSAPGNAWFGQGSGPIALDDVRCSGHESYLWSCPH 130 140 150 160 170 180 110 120 130 140 150 160 pF1KB5 LGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGED :::. :: : .::::.:. XP_011 NGWLSHNCGHGEDAGVICSAAQPQSTLRPESWPVRISPPVPTEGSESSLALRLVNGGDRC 190 200 210 220 230 240 >-- initn: 404 init1: 404 opt: 420 Z-score: 478.5 bits: 100.6 E(85289): 6.5e-20 Smith-Waterman score: 420; 44.4% identity (72.5% similar) in 142 aa overlap (20-156:1998-2139) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATN---QGRVEIFYRGQWG .:. .::.. ... :::::.. : :: XP_011 TSSYNRMTIHFRSDISFQNTGFLAWYNSFPSDATLRLVNLNSSYGLCAGRVEIYHGGTWG 1970 1980 1990 2000 2010 2020 50 60 70 80 90 100 pF1KB5 TVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSL ::::. : . .: :::: :: :..::: : ::.::::: ::.:.:.:::..: .:.. XP_011 TVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLDDVECSGTESTLWQCRNR 2030 2040 2050 2060 2070 2080 110 120 130 140 150 160 pF1KB5 GWLKSNCRHERDAGVVCTNETRSTHT--LDLSRELSEALGQIFDSQRGCDLSISVNVQGE ::.. :: :..::::.:... :: . :...: .. : :: . :.: XP_011 GWFSHNCNHREDAGVICSGNHLSTPAPFLNITRPNTDYSCGGFLSQPSGDFSSPFYPGNY 2090 2100 2110 2120 2130 2140 170 180 190 200 210 220 pF1KB5 DALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSV XP_011 PNNAKCVWDIEVQNNYRVTVIFRDVQLEGGCNYDYIEVFDGPYRSSPLIARVCDGARGSF 2150 2160 2170 2180 2190 2200 >-- initn: 396 init1: 360 opt: 362 Z-score: 411.2 bits: 88.2 E(85289): 3.7e-16 Smith-Waterman score: 362; 54.9% identity (76.9% similar) in 91 aa overlap (45-134:1391-1481) 20 30 40 50 60 70 pF1KB5 GTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQAL ::::::. :: .::.:::: :: ::.: XP_011 TAGSESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAP 1370 1380 1390 1400 1410 1420 80 90 100 110 120 130 pF1KB5 GRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCT-NETRSTHTL : : ::::::::.::.:.:.: :. : .: :::. :: :..::::.:. .... : . XP_011 GNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSASQSQPTPSP 1430 1440 1450 1460 1470 1480 140 150 160 170 180 190 pF1KB5 DLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNV : XP_011 DTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQL 1490 1500 1510 1520 1530 1540 >>XP_011537697 (OMIM: 601969) PREDICTED: deleted in mali (2532 aa) initn: 466 init1: 466 opt: 476 Z-score: 543.4 bits: 112.6 E(85289): 1.6e-23 Smith-Waterman score: 476; 47.7% identity (71.5% similar) in 151 aa overlap (14-163:1369-1518) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYR :.: : ... .::..:: :::::..:: XP_011 NCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYR 1340 1350 1360 1370 1380 1390 50 60 70 80 90 100 pF1KB5 GQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLAD :.::::::. :: .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : . XP_011 GSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1400 1410 1420 1430 1440 1450 110 120 130 140 150 160 pF1KB5 CKSLGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQ : :::. :: :..::::.:.. ..:. . : : :: . ..: :. . : . XP_011 CPHNGWLSHNCGHHEDAGVICSDTWPTSHASTAGSESSLALRLVNGGDR-CQGRVEVLYR 1460 1470 1480 1490 1500 1510 170 180 190 200 210 220 pF1KB5 GEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLS : XP_011 GSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1520 1530 1540 1550 1560 1570 >-- initn: 1738 init1: 452 opt: 452 Z-score: 515.6 bits: 107.5 E(85289): 5.6e-22 Smith-Waterman score: 458; 57.1% identity (78.6% similar) in 112 aa overlap (24-134:602-713) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: :::::..:::.::::::. : XP_011 SCPHNGWLSHNCGHSEDAGVICSGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSW 580 590 600 610 620 630 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: . :::. :: XP_011 DTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPNNGWLSHNC 640 650 660 670 680 690 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTN-ETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH :..::::.:. ..::: : XP_011 GHHEDAGVICSAAQSRSTPRPDTLSTITLPPSTVGSESSLTLRLVNGSDRCQGRVEVLYR 700 710 720 730 740 750 >-- initn: 1296 init1: 452 opt: 452 Z-score: 515.6 bits: 107.5 E(85289): 5.6e-22 Smith-Waterman score: 452; 59.4% identity (80.2% similar) in 101 aa overlap (24-124:363-463) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: :::::..:::.::::::. : XP_011 CSAPQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSW 340 350 360 370 380 390 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: :::. :: XP_011 DTSDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNC 400 410 420 430 440 450 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHT .: .::::.:. XP_011 QHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNGGDRCQGRVEVLYR 460 470 480 490 500 510 >-- initn: 1760 init1: 452 opt: 452 Z-score: 515.6 bits: 107.5 E(85289): 5.6e-22 Smith-Waterman score: 452; 59.4% identity (80.2% similar) in 101 aa overlap (24-124:862-962) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: :::::..:::.::::::. : XP_011 CSVSQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSW 840 850 860 870 880 890 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: :::. :: XP_011 DTSDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNC 900 910 920 930 940 950 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHT .: .::::.:. XP_011 QHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNGGDRCQGRVEVLYQ 960 970 980 990 1000 1010 >-- initn: 878 init1: 449 opt: 452 Z-score: 515.6 bits: 107.5 E(85289): 5.6e-22 Smith-Waterman score: 452; 52.8% identity (77.2% similar) in 123 aa overlap (14-134:1240-1362) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYR :.: : ... .::..:: :::::..:: XP_011 NCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYR 1210 1220 1230 1240 1250 1260 50 60 70 80 90 100 pF1KB5 GQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLAD :.::::::. :: .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : . XP_011 GSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1270 1280 1290 1300 1310 1320 110 120 130 140 150 160 pF1KB5 CKSLGWLKSNCRHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNV : :::. :: :..::::.:. .... : . : XP_011 CPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRC 1330 1340 1350 1360 1370 1380 170 180 190 200 210 220 pF1KB5 QGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITL XP_011 QGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRC 1390 1400 1410 1420 1430 1440 >-- initn: 472 init1: 436 opt: 447 Z-score: 509.8 bits: 106.4 E(85289): 1.2e-21 Smith-Waterman score: 447; 55.4% identity (78.6% similar) in 112 aa overlap (24-134:733-844) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:. :::::..:::.::::::. : XP_011 AAQSRSTPRPDTLSTITLPPSTVGSESSLTLRLVNGSDRCQGRVEVLYRGSWGTVCDDSW 710 720 730 740 750 760 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: :::. :: XP_011 DTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNC 770 780 790 800 810 820 120 130 140 150 160 170 pF1KB5 RHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH :..::::.:. ...: : . : XP_011 GHHEDAGVICSVSQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGS 830 840 850 860 870 880 >-- initn: 909 init1: 443 opt: 446 Z-score: 508.6 bits: 106.2 E(85289): 1.4e-21 Smith-Waterman score: 446; 52.0% identity (76.4% similar) in 123 aa overlap (14-134:1111-1233) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYR :.: : ... .::..:: :::::..:: XP_011 NCGHSEDAGVICSASQSRPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYR 1090 1100 1110 1120 1130 1140 50 60 70 80 90 100 pF1KB5 GQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLAD :.::::::. :: .::.:::: :: : .: : : ::::::::.::.:.:.: :. : . XP_011 GSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1150 1160 1170 1180 1190 1200 110 120 130 140 150 160 pF1KB5 CKSLGWLKSNCRHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNV : :::. :: :..::::.:. .... : . : XP_011 CPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRC 1210 1220 1230 1240 1250 1260 170 180 190 200 210 220 pF1KB5 QGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITL XP_011 QGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRC 1270 1280 1290 1300 1310 1320 >-- initn: 480 init1: 431 opt: 446 Z-score: 508.6 bits: 106.2 E(85289): 1.4e-21 Smith-Waterman score: 446; 50.0% identity (72.8% similar) in 136 aa overlap (2-134:969-1104) 10 20 pF1KB5 MTP-PRLFWVWLLVAGTQGVNDG-DMRLADG :: : . . : :.: : ... .::..: XP_011 WSCPHNGWLSHNCQHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNG 940 950 960 970 980 990 30 40 50 60 70 80 pF1KB5 GATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLD : :::::..:.:.::::::. :: .::.:::: :: : .: : : ::::::::.:: XP_011 GDRCQGRVEVLYQGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLD 1000 1010 1020 1030 1040 1050 90 100 110 120 130 140 pF1KB5 EVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFD .:.:.: :. : .: :::. :: : .::::.:. ...: : . : XP_011 DVRCSGHESYLWSCPHNGWLSHNCGHSEDAGVICSASQSRPTPSPDTWPTSHASTAGSES 1060 1070 1080 1090 1100 1110 150 160 170 180 190 200 pF1KB5 SQRGCDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDL XP_011 SLALRLVNGGDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNARFG 1120 1130 1140 1150 1160 1170 >-- initn: 474 init1: 439 opt: 446 Z-score: 508.6 bits: 106.2 E(85289): 1.4e-21 Smith-Waterman score: 446; 51.5% identity (72.3% similar) in 130 aa overlap (2-129:470-599) 10 20 pF1KB5 MTP-PRLFWVWLLVAGTQGVNDG-DMRLADG :: : . . : :.: : ... .::..: XP_011 WSCPHNGWLSHNCQHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNG 440 450 460 470 480 490 30 40 50 60 70 80 pF1KB5 GATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLD : :::::..:::.::::::. :: .::.:::: :: : : : : ::::::::.:: XP_011 GDRCQGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMLAPGNARFGQGSGPIVLD 500 510 520 530 540 550 90 100 110 120 130 140 pF1KB5 EVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDS .:.:.:.:. : .: :::. :: : .::::.:.. : XP_011 DVRCSGNESYLWSCPHNGWLSHNCGHSEDAGVICSGPESSLALRLVNGGDRCQGRVEVLY 560 570 580 590 600 610 150 160 170 180 190 200 pF1KB5 QRGCDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLL XP_011 RGSWGTVCDDSWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLW 620 630 640 650 660 670 >-- initn: 486 init1: 443 opt: 444 Z-score: 506.3 bits: 105.8 E(85289): 1.8e-21 Smith-Waterman score: 444; 51.2% identity (72.1% similar) in 129 aa overlap (10-134:1741-1869) 10 20 30 pF1KB5 MTPPRLFWVWL---LVAGTQGVNDG-DMRLADGGATNQG :: : : : : ... .::..:: .: XP_011 GWLSHNCGHHEDAGVICSAAQSQSTPRPDTWLTTNLPALTVGSESSLALRLVNGGDRCRG 1720 1730 1740 1750 1760 1770 40 50 60 70 80 90 pF1KB5 RVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTG :::..:::.::::::. :: .::.:::: :: : .: : : ::::::::.::.:.:.: XP_011 RVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSG 1780 1790 1800 1810 1820 1830 100 110 120 130 140 150 pF1KB5 TEASLADCKSLGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDL .:. : .: ::: :: :..::::.:. .. : : XP_011 NESYLWSCPHKGWLTHNCGHHEDAGVICSATQINSTTTDWWHPTTTTTARPSSNCGGFLF 1840 1850 1860 1870 1880 1890 160 170 180 190 200 210 pF1KB5 SISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSR XP_011 YASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSL 1900 1910 1920 1930 1940 1950 >-- initn: 469 init1: 433 opt: 442 Z-score: 504.0 bits: 105.3 E(85289): 2.5e-21 Smith-Waterman score: 442; 54.5% identity (75.0% similar) in 112 aa overlap (24-134:234-345) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: .::::..:::.::::::. : XP_011 AQPQSTLRPESWPVRISPPVPTEGSESSLALRLVNGGDRCRGRVEVLYRGSWGTVCDDYW 210 220 230 240 250 260 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: : .: : : ::::::::.::.:.:.: :. : .: ::: :: XP_011 DTNDANVVCRQLGCGWAMSAPGNAQFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLTHNC 270 280 290 300 310 320 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTN-ETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH : .::::.:. ..: : . : XP_011 GHSEDAGVICSAPQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGS 330 340 350 360 370 380 >-- initn: 800 init1: 432 opt: 435 Z-score: 495.9 bits: 103.8 E(85289): 7e-21 Smith-Waterman score: 435; 53.6% identity (76.8% similar) in 112 aa overlap (24-134:1628-1739) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: .::::..:.:.::::::. : XP_011 CSASQSQPTPSPDTWPTSRASTAGSESTLALRLVNGGDRCRGRVEVLYQGSWGTVCDDYW 1600 1610 1620 1630 1640 1650 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: : .: : : ::::::::.::.:.:.: :. : .: :::. :: XP_011 DTNDANVVCRQLGCGWAMSAPGNAQFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNC 1660 1670 1680 1690 1700 1710 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTN-ETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH :..::::.:. ...:: : XP_011 GHHEDAGVICSAAQSQSTPRPDTWLTTNLPALTVGSESSLALRLVNGGDRCRGRVEVLYR 1720 1730 1740 1750 1760 1770 >-- initn: 467 init1: 426 opt: 433 Z-score: 493.5 bits: 103.4 E(85289): 9.4e-21 Smith-Waterman score: 433; 56.0% identity (76.1% similar) in 109 aa overlap (17-124:94-202) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYRGQW .: ..: .::..: . ::::::.:::.: XP_011 SPISLESTLESTVAEGSLIPSESTLESTVAEGSDSGLALRLVNGDGRCQGRVEILYRGSW 70 80 90 100 110 120 50 60 70 80 90 100 pF1KB5 GTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKS :::::. :: .::.:::: :: : .: : : :::::::: ::.:.:.: :. : .: XP_011 GTVCDDSWDTNDANVVCRQLGCGWAMSAPGNAWFGQGSGPIALDDVRCSGHESYLWSCPH 130 140 150 160 170 180 110 120 130 140 150 160 pF1KB5 LGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGED :::. :: : .::::.:. XP_011 NGWLSHNCGHGEDAGVICSAAQPQSTLRPESWPVRISPPVPTEGSESSLALRLVNGGDRC 190 200 210 220 230 240 >-- initn: 404 init1: 404 opt: 420 Z-score: 478.5 bits: 100.6 E(85289): 6.5e-20 Smith-Waterman score: 420; 44.4% identity (72.5% similar) in 142 aa overlap (20-156:1998-2139) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATN---QGRVEIFYRGQWG .:. .::.. ... :::::.. : :: XP_011 TSSYNRMTIHFRSDISFQNTGFLAWYNSFPSDATLRLVNLNSSYGLCAGRVEIYHGGTWG 1970 1980 1990 2000 2010 2020 50 60 70 80 90 100 pF1KB5 TVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSL ::::. : . .: :::: :: :..::: : ::.::::: ::.:.:.:::..: .:.. XP_011 TVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLDDVECSGTESTLWQCRNR 2030 2040 2050 2060 2070 2080 110 120 130 140 150 160 pF1KB5 GWLKSNCRHERDAGVVCTNETRSTHT--LDLSRELSEALGQIFDSQRGCDLSISVNVQGE ::.. :: :..::::.:... :: . :...: .. : :: . :.: XP_011 GWFSHNCNHREDAGVICSGNHLSTPAPFLNITRPNTDYSCGGFLSQPSGDFSSPFYPGNY 2090 2100 2110 2120 2130 2140 170 180 190 200 210 220 pF1KB5 DALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSV XP_011 PNNAKCVWDIEVQNNYRVTVIFRDVQLEGGCNYDYIEVFDGPYRSSPLIARVCDGARGSF 2150 2160 2170 2180 2190 2200 >-- initn: 396 init1: 360 opt: 362 Z-score: 411.2 bits: 88.2 E(85289): 3.7e-16 Smith-Waterman score: 362; 54.9% identity (76.9% similar) in 91 aa overlap (45-134:1520-1610) 20 30 40 50 60 70 pF1KB5 GTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQAL ::::::. :: .::.:::: :: ::.: XP_011 TAGSESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAP 1490 1500 1510 1520 1530 1540 80 90 100 110 120 130 pF1KB5 GRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCT-NETRSTHTL : : ::::::::.::.:.:.: :. : .: :::. :: :..::::.:. .... : . XP_011 GNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSASQSQPTPSP 1550 1560 1570 1580 1590 1600 140 150 160 170 180 190 pF1KB5 DLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNV : XP_011 DTWPTSRASTAGSESTLALRLVNGGDRCRGRVEVLYQGSWGTVCDDYWDTNDANVVCRQL 1610 1620 1630 1640 1650 1660 >>XP_011537695 (OMIM: 601969) PREDICTED: deleted in mali (2532 aa) initn: 461 init1: 461 opt: 470 Z-score: 536.5 bits: 111.3 E(85289): 3.8e-23 Smith-Waterman score: 470; 47.0% identity (70.9% similar) in 151 aa overlap (14-163:1111-1260) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYR :.: : ... .::..:: :::::..:: XP_011 NCGHSEDAGVICSASQSRPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYR 1090 1100 1110 1120 1130 1140 50 60 70 80 90 100 pF1KB5 GQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLAD :.::::::. :: .::.:::: :: : .: : : ::::::::.::.:.:.: :. : . XP_011 GSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1150 1160 1170 1180 1190 1200 110 120 130 140 150 160 pF1KB5 CKSLGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQ : :::. :: :..::::.:.. ..:. . : : :: . ..: :. . : . XP_011 CPHNGWLSHNCGHHEDAGVICSDTWPTSHASTAGSESSLALRLVNGGDR-CQGRVEVLYR 1210 1220 1230 1240 1250 170 180 190 200 210 220 pF1KB5 GEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLS : XP_011 GSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1260 1270 1280 1290 1300 1310 >-- initn: 1291 init1: 452 opt: 452 Z-score: 515.6 bits: 107.5 E(85289): 5.6e-22 Smith-Waterman score: 452; 59.4% identity (80.2% similar) in 101 aa overlap (24-124:862-962) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: :::::..:::.::::::. : XP_011 CSVSQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSW 840 850 860 870 880 890 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: :::. :: XP_011 DTSDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNC 900 910 920 930 940 950 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHT .: .::::.:. XP_011 QHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNGGDRCQGRVEVLYQ 960 970 980 990 1000 1010 >-- initn: 868 init1: 452 opt: 452 Z-score: 515.6 bits: 107.5 E(85289): 5.6e-22 Smith-Waterman score: 458; 57.1% identity (78.6% similar) in 112 aa overlap (24-134:602-713) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: :::::..:::.::::::. : XP_011 SCPHNGWLSHNCGHSEDAGVICSGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSW 580 590 600 610 620 630 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: . :::. :: XP_011 DTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPNNGWLSHNC 640 650 660 670 680 690 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTN-ETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH :..::::.:. ..::: : XP_011 GHHEDAGVICSAAQSRSTPRPDTLSTITLPPSTVGSESSLTLRLVNGSDRCQGRVEVLYR 700 710 720 730 740 750 >-- initn: 1296 init1: 452 opt: 452 Z-score: 515.6 bits: 107.5 E(85289): 5.6e-22 Smith-Waterman score: 452; 59.4% identity (80.2% similar) in 101 aa overlap (24-124:363-463) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: :::::..:::.::::::. : XP_011 CSAPQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSW 340 350 360 370 380 390 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: :::. :: XP_011 DTSDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNC 400 410 420 430 440 450 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHT .: .::::.:. XP_011 QHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNGGDRCQGRVEVLYR 460 470 480 490 500 510 >-- initn: 492 init1: 449 opt: 452 Z-score: 515.6 bits: 107.5 E(85289): 5.6e-22 Smith-Waterman score: 452; 52.8% identity (77.2% similar) in 123 aa overlap (14-134:1359-1481) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYR :.: : ... .::..:: :::::..:: XP_011 NCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYR 1330 1340 1350 1360 1370 1380 50 60 70 80 90 100 pF1KB5 GQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLAD :.::::::. :: .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : . XP_011 GSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1390 1400 1410 1420 1430 1440 110 120 130 140 150 160 pF1KB5 CKSLGWLKSNCRHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNV : :::. :: :..::::.:. .... : . : XP_011 CPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRC 1450 1460 1470 1480 1490 1500 170 180 190 200 210 220 pF1KB5 QGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITL XP_011 QGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRC 1510 1520 1530 1540 1550 1560 >-- initn: 492 init1: 449 opt: 452 Z-score: 515.6 bits: 107.5 E(85289): 5.6e-22 Smith-Waterman score: 452; 52.8% identity (77.2% similar) in 123 aa overlap (14-134:1488-1610) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYR :.: : ... .::..:: :::::..:: XP_011 NCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYR 1460 1470 1480 1490 1500 1510 50 60 70 80 90 100 pF1KB5 GQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLAD :.::::::. :: .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : . XP_011 GSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1520 1530 1540 1550 1560 1570 110 120 130 140 150 160 pF1KB5 CKSLGWLKSNCRHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNV : :::. :: :..::::.:. .... : . : XP_011 CPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSRASTAGSESTLALRLVNGGDRC 1580 1590 1600 1610 1620 1630 170 180 190 200 210 220 pF1KB5 QGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITL XP_011 RGRVEVLYQGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQFGQGSGPIVLDDVRC 1640 1650 1660 1670 1680 1690 >-- initn: 472 init1: 436 opt: 447 Z-score: 509.8 bits: 106.4 E(85289): 1.2e-21 Smith-Waterman score: 447; 55.4% identity (78.6% similar) in 112 aa overlap (24-134:733-844) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:. :::::..:::.::::::. : XP_011 AAQSRSTPRPDTLSTITLPPSTVGSESSLTLRLVNGSDRCQGRVEVLYRGSWGTVCDDSW 710 720 730 740 750 760 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: :::. :: XP_011 DTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNC 770 780 790 800 810 820 120 130 140 150 160 170 pF1KB5 RHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH :..::::.:. ...: : . : XP_011 GHHEDAGVICSVSQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGS 830 840 850 860 870 880 >-- initn: 474 init1: 439 opt: 446 Z-score: 508.6 bits: 106.2 E(85289): 1.4e-21 Smith-Waterman score: 446; 51.5% identity (72.3% similar) in 130 aa overlap (2-129:470-599) 10 20 pF1KB5 MTP-PRLFWVWLLVAGTQGVNDG-DMRLADG :: : . . : :.: : ... .::..: XP_011 WSCPHNGWLSHNCQHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNG 440 450 460 470 480 490 30 40 50 60 70 80 pF1KB5 GATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLD : :::::..:::.::::::. :: .::.:::: :: : : : : ::::::::.:: XP_011 GDRCQGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMLAPGNARFGQGSGPIVLD 500 510 520 530 540 550 90 100 110 120 130 140 pF1KB5 EVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDS .:.:.:.:. : .: :::. :: : .::::.:.. : XP_011 DVRCSGNESYLWSCPHNGWLSHNCGHSEDAGVICSGPESSLALRLVNGGDRCQGRVEVLY 560 570 580 590 600 610 150 160 170 180 190 200 pF1KB5 QRGCDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLL XP_011 RGSWGTVCDDSWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLW 620 630 640 650 660 670 >-- initn: 480 init1: 431 opt: 446 Z-score: 508.6 bits: 106.2 E(85289): 1.4e-21 Smith-Waterman score: 446; 50.0% identity (72.8% similar) in 136 aa overlap (2-134:969-1104) 10 20 pF1KB5 MTP-PRLFWVWLLVAGTQGVNDG-DMRLADG :: : . . : :.: : ... .::..: XP_011 WSCPHNGWLSHNCQHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNG 940 950 960 970 980 990 30 40 50 60 70 80 pF1KB5 GATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLD : :::::..:.:.::::::. :: .::.:::: :: : .: : : ::::::::.:: XP_011 GDRCQGRVEVLYQGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLD 1000 1010 1020 1030 1040 1050 90 100 110 120 130 140 pF1KB5 EVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFD .:.:.: :. : .: :::. :: : .::::.:. ...: : . : XP_011 DVRCSGHESYLWSCPHNGWLSHNCGHSEDAGVICSASQSRPTPSPDTWPTSHASTAGSES 1060 1070 1080 1090 1100 1110 150 160 170 180 190 200 pF1KB5 SQRGCDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDL XP_011 SLALRLVNGGDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNARFG 1120 1130 1140 1150 1160 1170 >-- initn: 486 init1: 443 opt: 444 Z-score: 506.3 bits: 105.8 E(85289): 1.8e-21 Smith-Waterman score: 444; 51.2% identity (72.1% similar) in 129 aa overlap (10-134:1741-1869) 10 20 30 pF1KB5 MTPPRLFWVWL---LVAGTQGVNDG-DMRLADGGATNQG :: : : : : ... .::..:: .: XP_011 GWLSHNCGHHEDAGVICSAAQSQSTPRPDTWLTTNLPALTVGSESSLALRLVNGGDRCRG 1720 1730 1740 1750 1760 1770 40 50 60 70 80 90 pF1KB5 RVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTG :::..:::.::::::. :: .::.:::: :: : .: : : ::::::::.::.:.:.: XP_011 RVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSG 1780 1790 1800 1810 1820 1830 100 110 120 130 140 150 pF1KB5 TEASLADCKSLGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDL .:. : .: ::: :: :..::::.:. .. : : XP_011 NESYLWSCPHKGWLTHNCGHHEDAGVICSATQINSTTTDWWHPTTTTTARPSSNCGGFLF 1840 1850 1860 1870 1880 1890 160 170 180 190 200 210 pF1KB5 SISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSR XP_011 YASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSL 1900 1910 1920 1930 1940 1950 >-- initn: 469 init1: 433 opt: 442 Z-score: 504.0 bits: 105.3 E(85289): 2.5e-21 Smith-Waterman score: 442; 54.5% identity (75.0% similar) in 112 aa overlap (24-134:234-345) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: .::::..:::.::::::. : XP_011 AQPQSTLRPESWPVRISPPVPTEGSESSLALRLVNGGDRCRGRVEVLYRGSWGTVCDDYW 210 220 230 240 250 260 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: : .: : : ::::::::.::.:.:.: :. : .: ::: :: XP_011 DTNDANVVCRQLGCGWAMSAPGNAQFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLTHNC 270 280 290 300 310 320 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTN-ETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH : .::::.:. ..: : . : XP_011 GHSEDAGVICSAPQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGS 330 340 350 360 370 380 >-- initn: 461 init1: 429 opt: 435 Z-score: 495.9 bits: 103.8 E(85289): 7e-21 Smith-Waterman score: 435; 53.6% identity (76.8% similar) in 112 aa overlap (24-134:1628-1739) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: .::::..:.:.::::::. : XP_011 CSASQSQPTPSPDTWPTSRASTAGSESTLALRLVNGGDRCRGRVEVLYQGSWGTVCDDYW 1600 1610 1620 1630 1640 1650 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: : .: : : ::::::::.::.:.:.: :. : .: :::. :: XP_011 DTNDANVVCRQLGCGWAMSAPGNAQFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNC 1660 1670 1680 1690 1700 1710 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTN-ETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH :..::::.:. ...:: : XP_011 GHHEDAGVICSAAQSQSTPRPDTWLTTNLPALTVGSESSLALRLVNGGDRCRGRVEVLYR 1720 1730 1740 1750 1760 1770 >-- initn: 467 init1: 426 opt: 433 Z-score: 493.5 bits: 103.4 E(85289): 9.4e-21 Smith-Waterman score: 433; 56.0% identity (76.1% similar) in 109 aa overlap (17-124:94-202) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYRGQW .: ..: .::..: . ::::::.:::.: XP_011 SPISLESTLESTVAEGSLIPSESTLESTVAEGSDSGLALRLVNGDGRCQGRVEILYRGSW 70 80 90 100 110 120 50 60 70 80 90 100 pF1KB5 GTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKS :::::. :: .::.:::: :: : .: : : :::::::: ::.:.:.: :. : .: XP_011 GTVCDDSWDTNDANVVCRQLGCGWAMSAPGNAWFGQGSGPIALDDVRCSGHESYLWSCPH 130 140 150 160 170 180 110 120 130 140 150 160 pF1KB5 LGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGED :::. :: : .::::.:. XP_011 NGWLSHNCGHGEDAGVICSAAQPQSTLRPESWPVRISPPVPTEGSESSLALRLVNGGDRC 190 200 210 220 230 240 >-- initn: 404 init1: 404 opt: 420 Z-score: 478.5 bits: 100.6 E(85289): 6.5e-20 Smith-Waterman score: 420; 44.4% identity (72.5% similar) in 142 aa overlap (20-156:1998-2139) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATN---QGRVEIFYRGQWG .:. .::.. ... :::::.. : :: XP_011 TSSYNRMTIHFRSDISFQNTGFLAWYNSFPSDATLRLVNLNSSYGLCAGRVEIYHGGTWG 1970 1980 1990 2000 2010 2020 50 60 70 80 90 100 pF1KB5 TVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSL ::::. : . .: :::: :: :..::: : ::.::::: ::.:.:.:::..: .:.. XP_011 TVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLDDVECSGTESTLWQCRNR 2030 2040 2050 2060 2070 2080 110 120 130 140 150 160 pF1KB5 GWLKSNCRHERDAGVVCTNETRSTHT--LDLSRELSEALGQIFDSQRGCDLSISVNVQGE ::.. :: :..::::.:... :: . :...: .. : :: . :.: XP_011 GWFSHNCNHREDAGVICSGNHLSTPAPFLNITRPNTDYSCGGFLSQPSGDFSSPFYPGNY 2090 2100 2110 2120 2130 2140 170 180 190 200 210 220 pF1KB5 DALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSV XP_011 PNNAKCVWDIEVQNNYRVTVIFRDVQLEGGCNYDYIEVFDGPYRSSPLIARVCDGARGSF 2150 2160 2170 2180 2190 2200 >-- initn: 396 init1: 360 opt: 362 Z-score: 411.2 bits: 88.2 E(85289): 3.7e-16 Smith-Waterman score: 362; 54.9% identity (76.9% similar) in 91 aa overlap (45-134:1262-1352) 20 30 40 50 60 70 pF1KB5 GTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQAL ::::::. :: .::.:::: :: ::.: XP_011 TAGSESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAP 1240 1250 1260 1270 1280 1290 80 90 100 110 120 130 pF1KB5 GRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCT-NETRSTHTL : : ::::::::.::.:.:.: :. : .: :::. :: :..::::.:. .... : . XP_011 GNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSASQSQPTPSP 1300 1310 1320 1330 1340 1350 140 150 160 170 180 190 pF1KB5 DLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNV : XP_011 DTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQL 1360 1370 1380 1390 1400 1410 >>XP_011537692 (OMIM: 601969) PREDICTED: deleted in mali (2532 aa) initn: 3461 init1: 454 opt: 469 Z-score: 535.3 bits: 111.1 E(85289): 4.5e-23 Smith-Waterman score: 469; 51.7% identity (70.6% similar) in 143 aa overlap (24-163:862-1002) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: :::::..:::.::::::. : XP_011 CSVSQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSW 840 850 860 870 880 890 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: :::. :: XP_011 DTSDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNC 900 910 920 930 940 950 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTNETRSTHTLDLSR---ELSEALGQIFDSQRGCDLSISVNVQGEDALGFC .: .::::.:.. : : :: : : : :: . ..: :. . : :: XP_011 QHSEDAGVICSD-TLPTITLPASTVGSESSLALRLVNGGDR-CQGRVEVLYQGSWGTVCD 960 970 980 990 1000 180 190 200 210 220 230 pF1KB5 GHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKL XP_011 DSWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLS 1010 1020 1030 1040 1050 1060 >-- initn: 868 init1: 452 opt: 452 Z-score: 515.6 bits: 107.5 E(85289): 5.6e-22 Smith-Waterman score: 458; 57.1% identity (78.6% similar) in 112 aa overlap (24-134:602-713) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: :::::..:::.::::::. : XP_011 SCPHNGWLSHNCGHSEDAGVICSGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSW 580 590 600 610 620 630 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: . :::. :: XP_011 DTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPNNGWLSHNC 640 650 660 670 680 690 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTN-ETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH :..::::.:. ..::: : XP_011 GHHEDAGVICSAAQSRSTPRPDTLSTITLPPSTVGSESSLTLRLVNGSDRCQGRVEVLYR 700 710 720 730 740 750 >-- initn: 1296 init1: 452 opt: 452 Z-score: 515.6 bits: 107.5 E(85289): 5.6e-22 Smith-Waterman score: 452; 59.4% identity (80.2% similar) in 101 aa overlap (24-124:363-463) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: :::::..:::.::::::. : XP_011 CSAPQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSW 340 350 360 370 380 390 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: :::. :: XP_011 DTSDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNC 400 410 420 430 440 450 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHT .: .::::.:. XP_011 QHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNGGDRCQGRVEVLYR 460 470 480 490 500 510 >-- initn: 492 init1: 449 opt: 452 Z-score: 515.6 bits: 107.5 E(85289): 5.6e-22 Smith-Waterman score: 452; 52.8% identity (77.2% similar) in 123 aa overlap (14-134:1488-1610) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYR :.: : ... .::..:: :::::..:: XP_011 NCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYR 1460 1470 1480 1490 1500 1510 50 60 70 80 90 100 pF1KB5 GQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLAD :.::::::. :: .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : . XP_011 GSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1520 1530 1540 1550 1560 1570 110 120 130 140 150 160 pF1KB5 CKSLGWLKSNCRHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNV : :::. :: :..::::.:. .... : . : XP_011 CPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSRASTAGSESTLALRLVNGGDRC 1580 1590 1600 1610 1620 1630 170 180 190 200 210 220 pF1KB5 QGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITL XP_011 RGRVEVLYQGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQFGQGSGPIVLDDVRC 1640 1650 1660 1670 1680 1690 >-- initn: 884 init1: 449 opt: 452 Z-score: 515.6 bits: 107.5 E(85289): 5.6e-22 Smith-Waterman score: 452; 52.8% identity (77.2% similar) in 123 aa overlap (14-134:1359-1481) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYR :.: : ... .::..:: :::::..:: XP_011 NCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYR 1330 1340 1350 1360 1370 1380 50 60 70 80 90 100 pF1KB5 GQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLAD :.::::::. :: .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : . XP_011 GSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1390 1400 1410 1420 1430 1440 110 120 130 140 150 160 pF1KB5 CKSLGWLKSNCRHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNV : :::. :: :..::::.:. .... : . : XP_011 CPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRC 1450 1460 1470 1480 1490 1500 170 180 190 200 210 220 pF1KB5 QGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITL XP_011 QGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRC 1510 1520 1530 1540 1550 1560 >-- initn: 900 init1: 449 opt: 452 Z-score: 515.6 bits: 107.5 E(85289): 5.6e-22 Smith-Waterman score: 452; 52.8% identity (77.2% similar) in 123 aa overlap (14-134:1230-1352) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYR :.: : ... .::..:: :::::..:: XP_011 NCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYR 1200 1210 1220 1230 1240 1250 50 60 70 80 90 100 pF1KB5 GQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLAD :.::::::. :: .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : . XP_011 GSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1260 1270 1280 1290 1300 1310 110 120 130 140 150 160 pF1KB5 CKSLGWLKSNCRHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNV : :::. :: :..::::.:. .... : . : XP_011 CPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRC 1320 1330 1340 1350 1360 1370 170 180 190 200 210 220 pF1KB5 QGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITL XP_011 QGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRC 1380 1390 1400 1410 1420 1430 >-- initn: 472 init1: 436 opt: 447 Z-score: 509.8 bits: 106.4 E(85289): 1.2e-21 Smith-Waterman score: 447; 55.4% identity (78.6% similar) in 112 aa overlap (24-134:733-844) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:. :::::..:::.::::::. : XP_011 AAQSRSTPRPDTLSTITLPPSTVGSESSLTLRLVNGSDRCQGRVEVLYRGSWGTVCDDSW 710 720 730 740 750 760 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: :::. :: XP_011 DTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNC 770 780 790 800 810 820 120 130 140 150 160 170 pF1KB5 RHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH :..::::.:. ...: : . : XP_011 GHHEDAGVICSVSQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGS 830 840 850 860 870 880 >-- initn: 474 init1: 439 opt: 446 Z-score: 508.6 bits: 106.2 E(85289): 1.4e-21 Smith-Waterman score: 446; 51.5% identity (72.3% similar) in 130 aa overlap (2-129:470-599) 10 20 pF1KB5 MTP-PRLFWVWLLVAGTQGVNDG-DMRLADG :: : . . : :.: : ... .::..: XP_011 WSCPHNGWLSHNCQHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNG 440 450 460 470 480 490 30 40 50 60 70 80 pF1KB5 GATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLD : :::::..:::.::::::. :: .::.:::: :: : : : : ::::::::.:: XP_011 GDRCQGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMLAPGNARFGQGSGPIVLD 500 510 520 530 540 550 90 100 110 120 130 140 pF1KB5 EVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDS .:.:.:.:. : .: :::. :: : .::::.:.. : XP_011 DVRCSGNESYLWSCPHNGWLSHNCGHSEDAGVICSGPESSLALRLVNGGDRCQGRVEVLY 560 570 580 590 600 610 150 160 170 180 190 200 pF1KB5 QRGCDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLL XP_011 RGSWGTVCDDSWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLW 620 630 640 650 660 670 >-- initn: 816 init1: 443 opt: 446 Z-score: 508.6 bits: 106.2 E(85289): 1.4e-21 Smith-Waterman score: 446; 52.0% identity (76.4% similar) in 123 aa overlap (14-134:1101-1223) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYR :.: : ... .::..:: :::::..:: XP_011 NCGHSEDAGVICSASQSRPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYR 1080 1090 1100 1110 1120 1130 50 60 70 80 90 100 pF1KB5 GQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLAD :.::::::. :: .::.:::: :: : .: : : ::::::::.::.:.:.: :. : . XP_011 GSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1140 1150 1160 1170 1180 1190 110 120 130 140 150 160 pF1KB5 CKSLGWLKSNCRHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNV : :::. :: :..::::.:. .... : . : XP_011 CPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRC 1200 1210 1220 1230 1240 1250 170 180 190 200 210 220 pF1KB5 QGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITL XP_011 QGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRC 1260 1270 1280 1290 1300 1310 >-- initn: 486 init1: 443 opt: 444 Z-score: 506.3 bits: 105.8 E(85289): 1.8e-21 Smith-Waterman score: 444; 51.2% identity (72.1% similar) in 129 aa overlap (10-134:1741-1869) 10 20 30 pF1KB5 MTPPRLFWVWL---LVAGTQGVNDG-DMRLADGGATNQG :: : : : : ... .::..:: .: XP_011 GWLSHNCGHHEDAGVICSAAQSQSTPRPDTWLTTNLPALTVGSESSLALRLVNGGDRCRG 1720 1730 1740 1750 1760 1770 40 50 60 70 80 90 pF1KB5 RVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTG :::..:::.::::::. :: .::.:::: :: : .: : : ::::::::.::.:.:.: XP_011 RVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSG 1780 1790 1800 1810 1820 1830 100 110 120 130 140 150 pF1KB5 TEASLADCKSLGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDL .:. : .: ::: :: :..::::.:. .. : : XP_011 NESYLWSCPHKGWLTHNCGHHEDAGVICSATQINSTTTDWWHPTTTTTARPSSNCGGFLF 1840 1850 1860 1870 1880 1890 160 170 180 190 200 210 pF1KB5 SISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSR XP_011 YASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSL 1900 1910 1920 1930 1940 1950 >-- initn: 469 init1: 433 opt: 442 Z-score: 504.0 bits: 105.3 E(85289): 2.5e-21 Smith-Waterman score: 442; 54.5% identity (75.0% similar) in 112 aa overlap (24-134:234-345) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: .::::..:::.::::::. : XP_011 AQPQSTLRPESWPVRISPPVPTEGSESSLALRLVNGGDRCRGRVEVLYRGSWGTVCDDYW 210 220 230 240 250 260 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: : .: : : ::::::::.::.:.:.: :. : .: ::: :: XP_011 DTNDANVVCRQLGCGWAMSAPGNAQFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLTHNC 270 280 290 300 310 320 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTN-ETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH : .::::.:. ..: : . : XP_011 GHSEDAGVICSAPQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGS 330 340 350 360 370 380 >-- initn: 461 init1: 429 opt: 435 Z-score: 495.9 bits: 103.8 E(85289): 7e-21 Smith-Waterman score: 435; 53.6% identity (76.8% similar) in 112 aa overlap (24-134:1628-1739) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: .::::..:.:.::::::. : XP_011 CSASQSQPTPSPDTWPTSRASTAGSESTLALRLVNGGDRCRGRVEVLYQGSWGTVCDDYW 1600 1610 1620 1630 1640 1650 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: : .: : : ::::::::.::.:.:.: :. : .: :::. :: XP_011 DTNDANVVCRQLGCGWAMSAPGNAQFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNC 1660 1670 1680 1690 1700 1710 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTN-ETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH :..::::.:. ...:: : XP_011 GHHEDAGVICSAAQSQSTPRPDTWLTTNLPALTVGSESSLALRLVNGGDRCRGRVEVLYR 1720 1730 1740 1750 1760 1770 >-- initn: 467 init1: 426 opt: 433 Z-score: 493.5 bits: 103.4 E(85289): 9.4e-21 Smith-Waterman score: 433; 56.0% identity (76.1% similar) in 109 aa overlap (17-124:94-202) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYRGQW .: ..: .::..: . ::::::.:::.: XP_011 SPISLESTLESTVAEGSLIPSESTLESTVAEGSDSGLALRLVNGDGRCQGRVEILYRGSW 70 80 90 100 110 120 50 60 70 80 90 100 pF1KB5 GTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKS :::::. :: .::.:::: :: : .: : : :::::::: ::.:.:.: :. : .: XP_011 GTVCDDSWDTNDANVVCRQLGCGWAMSAPGNAWFGQGSGPIALDDVRCSGHESYLWSCPH 130 140 150 160 170 180 110 120 130 140 150 160 pF1KB5 LGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGED :::. :: : .::::.:. XP_011 NGWLSHNCGHGEDAGVICSAAQPQSTLRPESWPVRISPPVPTEGSESSLALRLVNGGDRC 190 200 210 220 230 240 >-- initn: 404 init1: 404 opt: 420 Z-score: 478.5 bits: 100.6 E(85289): 6.5e-20 Smith-Waterman score: 420; 44.4% identity (72.5% similar) in 142 aa overlap (20-156:1998-2139) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATN---QGRVEIFYRGQWG .:. .::.. ... :::::.. : :: XP_011 TSSYNRMTIHFRSDISFQNTGFLAWYNSFPSDATLRLVNLNSSYGLCAGRVEIYHGGTWG 1970 1980 1990 2000 2010 2020 50 60 70 80 90 100 pF1KB5 TVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSL ::::. : . .: :::: :: :..::: : ::.::::: ::.:.:.:::..: .:.. XP_011 TVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLDDVECSGTESTLWQCRNR 2030 2040 2050 2060 2070 2080 110 120 130 140 150 160 pF1KB5 GWLKSNCRHERDAGVVCTNETRSTHT--LDLSRELSEALGQIFDSQRGCDLSISVNVQGE ::.. :: :..::::.:... :: . :...: .. : :: . :.: XP_011 GWFSHNCNHREDAGVICSGNHLSTPAPFLNITRPNTDYSCGGFLSQPSGDFSSPFYPGNY 2090 2100 2110 2120 2130 2140 170 180 190 200 210 220 pF1KB5 DALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSV XP_011 PNNAKCVWDIEVQNNYRVTVIFRDVQLEGGCNYDYIEVFDGPYRSSPLIARVCDGARGSF 2150 2160 2170 2180 2190 2200 >-- initn: 387 init1: 351 opt: 359 Z-score: 407.7 bits: 87.5 E(85289): 5.7e-16 Smith-Waterman score: 359; 54.9% identity (74.7% similar) in 91 aa overlap (45-134:1004-1094) 20 30 40 50 60 70 pF1KB5 GTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQAL ::::::. :: .::.:::: :: : .: XP_011 TVGSESSLALRLVNGGDRCQGRVEVLYQGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAP 980 990 1000 1010 1020 1030 80 90 100 110 120 130 pF1KB5 GRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCT-NETRSTHTL : : ::::::::.::.:.:.: :. : .: :::. :: : .::::.:. ...: : . XP_011 GNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHSEDAGVICSASQSRPTPSP 1040 1050 1060 1070 1080 1090 140 150 160 170 180 190 pF1KB5 DLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNV : XP_011 DTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQL 1100 1110 1120 1130 1140 1150 >>NP_981961 (OMIM: 605545) scavenger receptor cysteine-r (1121 aa) initn: 1096 init1: 459 opt: 462 Z-score: 532.3 bits: 109.4 E(85289): 6.6e-23 Smith-Waterman score: 462; 47.3% identity (76.0% similar) in 129 aa overlap (19-147:714-842) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTV ...:..::..::. :::::...:.:::. NP_981 GNQSQTLSSCNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGRCAGRVEIYHEGSWGTI 690 700 710 720 730 740 50 60 70 80 90 100 pF1KB5 CDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGW ::. :::.:: :::: :: .: .: : : ::.:.::: :::..:.: :. . .:.: :: NP_981 CDDSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMKCNGKESRIWQCHSHGW 750 760 770 780 790 800 110 120 130 140 150 160 pF1KB5 LKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALG ..::::..::::.:.. : . ::: . ..: NP_981 GQQNCRHKEDAGVICSEFMSLRLTSEASREACAGRLEVFYNGAWGTVGKSSMSETTVGVV 810 820 830 840 850 860 170 180 190 200 210 220 pF1KB5 FCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFH NP_981 CRQLGCADKGKINPASLDKAMSIPMWVDNVQCPKGPDTLWQCPSSPWEKRLASPSEETWI 870 880 890 900 910 920 >-- initn: 390 init1: 390 opt: 399 Z-score: 459.2 bits: 95.9 E(85289): 7.7e-19 Smith-Waterman score: 399; 52.4% identity (78.1% similar) in 105 aa overlap (21-125:926-1030) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCD :. .:: .: .. .:::::.. :.:::::: NP_981 PKGPDTLWQCPSSPWEKRLASPSEETWITCDNKIRLQEGPTSCSGRVEIWHGGSWGTVCD 900 910 920 930 940 950 60 70 80 90 100 110 pF1KB5 NLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLK . ::: ::.:::. :: : .:. .: ::::.::: :.::.: :.:.:: :: . : . NP_981 DSWDLDDAQVVCQQLGCGPALKAFKEAEFGQGTGPIWLNEVKCKGNESSLWDCPARRWGH 960 970 980 990 1000 1010 120 130 140 150 160 170 pF1KB5 SNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFC :.: :..::.: ::. NP_981 SECGHKEDAAVNCTDISVQKTPQKATTGRSSRQSSFIAVGILGVVLLAIFVALFFLTKKR 1020 1030 1040 1050 1060 1070 >-- initn: 1007 init1: 373 opt: 385 Z-score: 442.9 bits: 92.9 E(85289): 6.2e-18 Smith-Waterman score: 385; 42.6% identity (68.1% similar) in 141 aa overlap (20-154:152-292) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG---DMRLADGGATNQGRVEIFYRGQWG .:: .:::. :: .::.:: ..:.:: NP_981 GNESALWDCKHDGWGKHSNCTHQQDAGVTCSDGSNLEMRLTRGGNMCSGRIEIKFQGRWG 130 140 150 160 170 180 50 60 70 80 90 100 pF1KB5 TVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSL ::::. ... :::.:: : .:.. : . ::.::::: .:.. :.:.:..: .:: NP_981 TVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICNGNESALWNCKHQ 190 200 210 220 230 240 110 120 130 140 150 160 pF1KB5 GWLKSNCRHERDAGVVCTNETR-STHTLDLSRELSEALGQIFDSQRG--CDLSISVNVQG :: : :: : .::::.:.. . : . .: : : : :... : :: NP_981 GWGKHNCDHAEDAGVICSKGADLSLRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAA 250 260 270 280 290 300 170 180 190 200 210 220 pF1KB5 EDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSS NP_981 VACKQLGCPTAVTAIGRVNASKGFGHIWLDSVSCQGHEPAIWQCKHHEWGKHYCNHNEDA 310 320 330 340 350 360 >-- initn: 350 init1: 274 opt: 360 Z-score: 413.9 bits: 87.5 E(85289): 2.6e-16 Smith-Waterman score: 360; 43.8% identity (68.0% similar) in 128 aa overlap (1-123:24-151) 10 20 30 pF1KB5 MTPPRLFWVWLL----VAGTQGVNDGDMRLADGGATN ..: . : :: :... : .: ..::.:: NP_981 MSKLRMVLLEDSGSADFRRHFVNLSPFTITVVLLLSACFVTSSLGGTDKELRLVDGENKC 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 QGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQC .::::. . .:::::.: :.. .::.: :: .: .: : : . ::: : .:.:.: NP_981 SGRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPGWANSSAGSGRIWMDHVSC 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB5 TGTEASLADCKSLGWLK-SNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRG :.:..: ::: :: : ::: :..::::.: NP_981 RGNESALWDCKHDGWGKHSNCTHQQDAGVTCSDGSNLEMRLTRGGNMCSGRIEIKFQGRW 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB5 CDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYF NP_981 GTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICNGNESALWNCKH 190 200 210 220 230 240 >-- initn: 537 init1: 279 opt: 279 Z-score: 320.0 bits: 70.1 E(85289): 4.4e-11 Smith-Waterman score: 279; 40.8% identity (64.1% similar) in 103 aa overlap (25-127:479-581) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWD ::. : .::::. . ::..::. .. NP_981 LWDCKNWQWGGLTCDHYEEAKITCSAHREPRLVGGDIPCSGRVEVKHGDTWGSICDSDFS 450 460 470 480 490 500 60 70 80 90 100 110 pF1KB5 LTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCR : :::.:: : .... :: : ::.:.: : .: :: : :. :. : ...: NP_981 LEAASVLCRELQCGTVVSILGGAHFGEGNGQIWAEEFQCEGHESHLSLCPVAPRPEGTCS 510 520 530 540 550 560 120 130 140 150 160 170 pF1KB5 HERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTV : ::.::::. : NP_981 HSRDVGVVCSRYTEIRLVNGKTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGV 570 580 590 600 610 620 >-- initn: 257 init1: 237 opt: 273 Z-score: 313.0 bits: 68.8 E(85289): 1.1e-10 Smith-Waterman score: 273; 36.9% identity (61.5% similar) in 122 aa overlap (23-144:582-699) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNL ..::..: . .::::. : ::..:.. NP_981 SHLSLCPVAPRPEGTCSHSRDVGVVCSRYTEIRLVNGKTPCEGRVELKTLGAWGSLCNSH 560 570 580 590 600 610 60 70 80 90 100 110 pF1KB5 WDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSN ::. :: :.:. : : .. : : ::.:.: : .::::: ..:: . : NP_981 WDIEDAHVLCQQLKCGVALSTPGGARFGKGNGQIWRHMFHCTGTEQHMGDCPVTALGASL 620 630 640 650 660 670 120 130 140 150 160 170 pF1KB5 CRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH : :. :.:.:... .: :: : .:: NP_981 CPSEQVASVICSGNQSQT----LSSCNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGR 680 690 700 710 720 180 190 200 210 220 230 pF1KB5 TVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKLAS NP_981 CAGRVEIYHEGSWGTICDDSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMK 730 740 750 760 770 780 >-- initn: 270 init1: 232 opt: 234 Z-score: 267.8 bits: 60.5 E(85289): 3.5e-08 Smith-Waterman score: 234; 32.7% identity (55.1% similar) in 147 aa overlap (53-186:295-436) 30 40 50 60 70 80 pF1KB5 DMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQG :: ::.:.:. :: .:. :.::. ..: NP_981 SLRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPTAVTAIGRVNASKG 270 280 290 300 310 320 90 100 110 120 130 pF1KB5 SGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCTN----ETR-----STHTL : : :: :.: : : .. .:: : : : :..::::.:.. : : : . NP_981 FGHIWLDSVSCQGHEPAIWQCKHHEWGKHYCNHNEDAGVTCSDGSDLELRLRGGGSRCAG 330 340 350 360 370 380 140 150 160 170 180 pF1KB5 DLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILT----ANLEAQALWKEP . :... ::.. : : . : : :: :: .. . ....: : NP_981 TVEVEIQRLLGKVCDRGWGLKEADVVCRQ----LG-CGSALKTSYQVYSKIQATNTWLFL 390 400 410 420 430 190 200 210 220 230 240 pF1KB5 GSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKLASAYGARQLQGYCASLFAI NP_981 SSCNGNETSLWDCKNWQWGGLTCDHYEEAKITCSAHREPRLVGGDIPCSGRVEVKHGDTW 440 450 460 470 480 490 >>XP_005253586 (OMIM: 605545) PREDICTED: scavenger recep (1124 aa) initn: 1096 init1: 459 opt: 462 Z-score: 532.2 bits: 109.4 E(85289): 6.6e-23 Smith-Waterman score: 462; 47.3% identity (76.0% similar) in 129 aa overlap (19-147:714-842) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTV ...:..::..::. :::::...:.:::. XP_005 GNQSQTLSSCNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGRCAGRVEIYHEGSWGTI 690 700 710 720 730 740 50 60 70 80 90 100 pF1KB5 CDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGW ::. :::.:: :::: :: .: .: : : ::.:.::: :::..:.: :. . .:.: :: XP_005 CDDSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMKCNGKESRIWQCHSHGW 750 760 770 780 790 800 110 120 130 140 150 160 pF1KB5 LKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALG ..::::..::::.:.. : . ::: . ..: XP_005 GQQNCRHKEDAGVICSEFMSLRLTSEASREACAGRLEVFYNGAWGTVGKSSMSETTVGVV 810 820 830 840 850 860 170 180 190 200 210 220 pF1KB5 FCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFH XP_005 CRQLGCADKGKINPASLDKAMSIPMWVDNVQCPKGPDTLWQCPSSPWEKRLASPSEETWI 870 880 890 900 910 920 >-- initn: 390 init1: 390 opt: 399 Z-score: 459.2 bits: 95.9 E(85289): 7.8e-19 Smith-Waterman score: 399; 52.4% identity (78.1% similar) in 105 aa overlap (21-125:926-1030) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCD :. .:: .: .. .:::::.. :.:::::: XP_005 PKGPDTLWQCPSSPWEKRLASPSEETWITCDNKIRLQEGPTSCSGRVEIWHGGSWGTVCD 900 910 920 930 940 950 60 70 80 90 100 110 pF1KB5 NLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLK . ::: ::.:::. :: : .:. .: ::::.::: :.::.: :.:.:: :: . : . XP_005 DSWDLDDAQVVCQQLGCGPALKAFKEAEFGQGTGPIWLNEVKCKGNESSLWDCPARRWGH 960 970 980 990 1000 1010 120 130 140 150 160 170 pF1KB5 SNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFC :.: :..::.: ::. XP_005 SECGHKEDAAVNCTDISVQKTPQKATTGRSSRQSSFIAVGILGVVLLAIFVALFFLTKKR 1020 1030 1040 1050 1060 1070 >-- initn: 1007 init1: 373 opt: 385 Z-score: 442.9 bits: 92.9 E(85289): 6.2e-18 Smith-Waterman score: 385; 42.6% identity (68.1% similar) in 141 aa overlap (20-154:152-292) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG---DMRLADGGATNQGRVEIFYRGQWG .:: .:::. :: .::.:: ..:.:: XP_005 GNESALWDCKHDGWGKHSNCTHQQDAGVTCSDGSNLEMRLTRGGNMCSGRIEIKFQGRWG 130 140 150 160 170 180 50 60 70 80 90 100 pF1KB5 TVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSL ::::. ... :::.:: : .:.. : . ::.::::: .:.. :.:.:..: .:: XP_005 TVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICNGNESALWNCKHQ 190 200 210 220 230 240 110 120 130 140 150 160 pF1KB5 GWLKSNCRHERDAGVVCTNETR-STHTLDLSRELSEALGQIFDSQRG--CDLSISVNVQG :: : :: : .::::.:.. . : . .: : : : :... : :: XP_005 GWGKHNCDHAEDAGVICSKGADLSLRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAA 250 260 270 280 290 300 170 180 190 200 210 220 pF1KB5 EDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSS XP_005 VACKQLGCPTAVTAIGRVNASKGFGHIWLDSVSCQGHEPAIWQCKHHEWGKHYCNHNEDA 310 320 330 340 350 360 >-- initn: 350 init1: 274 opt: 360 Z-score: 413.9 bits: 87.5 E(85289): 2.6e-16 Smith-Waterman score: 360; 43.8% identity (68.0% similar) in 128 aa overlap (1-123:24-151) 10 20 30 pF1KB5 MTPPRLFWVWLL----VAGTQGVNDGDMRLADGGATN ..: . : :: :... : .: ..::.:: XP_005 MSKLRMVLLEDSGSADFRRHFVNLSPFTITVVLLLSACFVTSSLGGTDKELRLVDGENKC 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 QGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQC .::::. . .:::::.: :.. .::.: :: .: .: : : . ::: : .:.:.: XP_005 SGRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPGWANSSAGSGRIWMDHVSC 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB5 TGTEASLADCKSLGWLK-SNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRG :.:..: ::: :: : ::: :..::::.: XP_005 RGNESALWDCKHDGWGKHSNCTHQQDAGVTCSDGSNLEMRLTRGGNMCSGRIEIKFQGRW 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB5 CDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYF XP_005 GTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICNGNESALWNCKH 190 200 210 220 230 240 >-- initn: 537 init1: 279 opt: 279 Z-score: 320.0 bits: 70.1 E(85289): 4.4e-11 Smith-Waterman score: 279; 40.8% identity (64.1% similar) in 103 aa overlap (25-127:479-581) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWD ::. : .::::. . ::..::. .. XP_005 LWDCKNWQWGGLTCDHYEEAKITCSAHREPRLVGGDIPCSGRVEVKHGDTWGSICDSDFS 450 460 470 480 490 500 60 70 80 90 100 110 pF1KB5 LTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCR : :::.:: : .... :: : ::.:.: : .: :: : :. :. : ...: XP_005 LEAASVLCRELQCGTVVSILGGAHFGEGNGQIWAEEFQCEGHESHLSLCPVAPRPEGTCS 510 520 530 540 550 560 120 130 140 150 160 170 pF1KB5 HERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTV : ::.::::. : XP_005 HSRDVGVVCSRYTEIRLVNGKTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGV 570 580 590 600 610 620 >-- initn: 257 init1: 237 opt: 273 Z-score: 313.0 bits: 68.8 E(85289): 1.1e-10 Smith-Waterman score: 273; 36.9% identity (61.5% similar) in 122 aa overlap (23-144:582-699) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNL ..::..: . .::::. : ::..:.. XP_005 SHLSLCPVAPRPEGTCSHSRDVGVVCSRYTEIRLVNGKTPCEGRVELKTLGAWGSLCNSH 560 570 580 590 600 610 60 70 80 90 100 110 pF1KB5 WDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSN ::. :: :.:. : : .. : : ::.:.: : .::::: ..:: . : XP_005 WDIEDAHVLCQQLKCGVALSTPGGARFGKGNGQIWRHMFHCTGTEQHMGDCPVTALGASL 620 630 640 650 660 670 120 130 140 150 160 170 pF1KB5 CRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH : :. :.:.:... .: :: : .:: XP_005 CPSEQVASVICSGNQSQT----LSSCNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGR 680 690 700 710 720 180 190 200 210 220 230 pF1KB5 TVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKLAS XP_005 CAGRVEIYHEGSWGTICDDSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMK 730 740 750 760 770 780 >-- initn: 270 init1: 232 opt: 234 Z-score: 267.8 bits: 60.5 E(85289): 3.6e-08 Smith-Waterman score: 234; 32.7% identity (55.1% similar) in 147 aa overlap (53-186:295-436) 30 40 50 60 70 80 pF1KB5 DMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQG :: ::.:.:. :: .:. :.::. ..: XP_005 SLRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPTAVTAIGRVNASKG 270 280 290 300 310 320 90 100 110 120 130 pF1KB5 SGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCTN----ETR-----STHTL : : :: :.: : : .. .:: : : : :..::::.:.. : : : . XP_005 FGHIWLDSVSCQGHEPAIWQCKHHEWGKHYCNHNEDAGVTCSDGSDLELRLRGGGSRCAG 330 340 350 360 370 380 140 150 160 170 180 pF1KB5 DLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILT----ANLEAQALWKEP . :... ::.. : : . : : :: :: .. . ....: : XP_005 TVEVEIQRLLGKVCDRGWGLKEADVVCRQ----LG-CGSALKTSYQVYSKIQATNTWLFL 390 400 410 420 430 190 200 210 220 230 240 pF1KB5 GSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKLASAYGARQLQGYCASLFAI XP_005 SSCNGNETSLWDCKNWQWGGLTCDHYEEAKITCSAHREPRLVGGDIPCSGRVEVKHGDTW 440 450 460 470 480 490 >>NP_004235 (OMIM: 605545) scavenger receptor cysteine-r (1156 aa) initn: 1096 init1: 459 opt: 462 Z-score: 532.1 bits: 109.4 E(85289): 6.7e-23 Smith-Waterman score: 462; 47.3% identity (76.0% similar) in 129 aa overlap (19-147:714-842) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTV ...:..::..::. :::::...:.:::. NP_004 GNQSQTLSSCNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGRCAGRVEIYHEGSWGTI 690 700 710 720 730 740 50 60 70 80 90 100 pF1KB5 CDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGW ::. :::.:: :::: :: .: .: : : ::.:.::: :::..:.: :. . .:.: :: NP_004 CDDSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMKCNGKESRIWQCHSHGW 750 760 770 780 790 800 110 120 130 140 150 160 pF1KB5 LKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALG ..::::..::::.:.. : . ::: . ..: NP_004 GQQNCRHKEDAGVICSEFMSLRLTSEASREACAGRLEVFYNGAWGTVGKSSMSETTVGVV 810 820 830 840 850 860 170 180 190 200 210 220 pF1KB5 FCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFH NP_004 CRQLGCADKGKINPASLDKAMSIPMWVDNVQCPKGPDTLWQCPSSPWEKRLASPSEETWI 870 880 890 900 910 920 >-- initn: 390 init1: 390 opt: 399 Z-score: 459.0 bits: 95.9 E(85289): 7.9e-19 Smith-Waterman score: 399; 52.4% identity (78.1% similar) in 105 aa overlap (21-125:926-1030) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCD :. .:: .: .. .:::::.. :.:::::: NP_004 PKGPDTLWQCPSSPWEKRLASPSEETWITCDNKIRLQEGPTSCSGRVEIWHGGSWGTVCD 900 910 920 930 940 950 60 70 80 90 100 110 pF1KB5 NLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLK . ::: ::.:::. :: : .:. .: ::::.::: :.::.: :.:.:: :: . : . NP_004 DSWDLDDAQVVCQQLGCGPALKAFKEAEFGQGTGPIWLNEVKCKGNESSLWDCPARRWGH 960 970 980 990 1000 1010 120 130 140 150 160 170 pF1KB5 SNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFC :.: :..::.: ::. NP_004 SECGHKEDAAVNCTDISVQKTPQKATTGRSSRQSSFIAVGILGVVLLAIFVALFFLTKKR 1020 1030 1040 1050 1060 1070 >-- initn: 1007 init1: 373 opt: 385 Z-score: 442.8 bits: 92.9 E(85289): 6.4e-18 Smith-Waterman score: 385; 42.6% identity (68.1% similar) in 141 aa overlap (20-154:152-292) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG---DMRLADGGATNQGRVEIFYRGQWG .:: .:::. :: .::.:: ..:.:: NP_004 GNESALWDCKHDGWGKHSNCTHQQDAGVTCSDGSNLEMRLTRGGNMCSGRIEIKFQGRWG 130 140 150 160 170 180 50 60 70 80 90 100 pF1KB5 TVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSL ::::. ... :::.:: : .:.. : . ::.::::: .:.. :.:.:..: .:: NP_004 TVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICNGNESALWNCKHQ 190 200 210 220 230 240 110 120 130 140 150 160 pF1KB5 GWLKSNCRHERDAGVVCTNETR-STHTLDLSRELSEALGQIFDSQRG--CDLSISVNVQG :: : :: : .::::.:.. . : . .: : : : :... : :: NP_004 GWGKHNCDHAEDAGVICSKGADLSLRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAA 250 260 270 280 290 300 170 180 190 200 210 220 pF1KB5 EDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSS NP_004 VACKQLGCPTAVTAIGRVNASKGFGHIWLDSVSCQGHEPAIWQCKHHEWGKHYCNHNEDA 310 320 330 340 350 360 >-- initn: 350 init1: 274 opt: 360 Z-score: 413.7 bits: 87.5 E(85289): 2.6e-16 Smith-Waterman score: 360; 43.8% identity (68.0% similar) in 128 aa overlap (1-123:24-151) 10 20 30 pF1KB5 MTPPRLFWVWLL----VAGTQGVNDGDMRLADGGATN ..: . : :: :... : .: ..::.:: NP_004 MSKLRMVLLEDSGSADFRRHFVNLSPFTITVVLLLSACFVTSSLGGTDKELRLVDGENKC 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 QGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQC .::::. . .:::::.: :.. .::.: :: .: .: : : . ::: : .:.:.: NP_004 SGRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPGWANSSAGSGRIWMDHVSC 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB5 TGTEASLADCKSLGWLK-SNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRG :.:..: ::: :: : ::: :..::::.: NP_004 RGNESALWDCKHDGWGKHSNCTHQQDAGVTCSDGSNLEMRLTRGGNMCSGRIEIKFQGRW 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB5 CDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYF NP_004 GTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICNGNESALWNCKH 190 200 210 220 230 240 >-- initn: 537 init1: 279 opt: 279 Z-score: 319.8 bits: 70.1 E(85289): 4.5e-11 Smith-Waterman score: 279; 40.8% identity (64.1% similar) in 103 aa overlap (25-127:479-581) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWD ::. : .::::. . ::..::. .. NP_004 LWDCKNWQWGGLTCDHYEEAKITCSAHREPRLVGGDIPCSGRVEVKHGDTWGSICDSDFS 450 460 470 480 490 500 60 70 80 90 100 110 pF1KB5 LTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCR : :::.:: : .... :: : ::.:.: : .: :: : :. :. : ...: NP_004 LEAASVLCRELQCGTVVSILGGAHFGEGNGQIWAEEFQCEGHESHLSLCPVAPRPEGTCS 510 520 530 540 550 560 120 130 140 150 160 170 pF1KB5 HERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTV : ::.::::. : NP_004 HSRDVGVVCSRYTEIRLVNGKTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGV 570 580 590 600 610 620 >-- initn: 257 init1: 237 opt: 273 Z-score: 312.8 bits: 68.8 E(85289): 1.1e-10 Smith-Waterman score: 273; 36.9% identity (61.5% similar) in 122 aa overlap (23-144:582-699) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNL ..::..: . .::::. : ::..:.. NP_004 SHLSLCPVAPRPEGTCSHSRDVGVVCSRYTEIRLVNGKTPCEGRVELKTLGAWGSLCNSH 560 570 580 590 600 610 60 70 80 90 100 110 pF1KB5 WDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSN ::. :: :.:. : : .. : : ::.:.: : .::::: ..:: . : NP_004 WDIEDAHVLCQQLKCGVALSTPGGARFGKGNGQIWRHMFHCTGTEQHMGDCPVTALGASL 620 630 640 650 660 670 120 130 140 150 160 170 pF1KB5 CRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH : :. :.:.:... .: :: : .:: NP_004 CPSEQVASVICSGNQSQT----LSSCNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGR 680 690 700 710 720 180 190 200 210 220 230 pF1KB5 TVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKLAS NP_004 CAGRVEIYHEGSWGTICDDSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMK 730 740 750 760 770 780 >-- initn: 270 init1: 232 opt: 234 Z-score: 267.6 bits: 60.5 E(85289): 3.6e-08 Smith-Waterman score: 234; 32.7% identity (55.1% similar) in 147 aa overlap (53-186:295-436) 30 40 50 60 70 80 pF1KB5 DMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQG :: ::.:.:. :: .:. :.::. ..: NP_004 SLRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPTAVTAIGRVNASKG 270 280 290 300 310 320 90 100 110 120 130 pF1KB5 SGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCTN----ETR-----STHTL : : :: :.: : : .. .:: : : : :..::::.:.. : : : . NP_004 FGHIWLDSVSCQGHEPAIWQCKHHEWGKHYCNHNEDAGVTCSDGSDLELRLRGGGSRCAG 330 340 350 360 370 380 140 150 160 170 180 pF1KB5 DLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILT----ANLEAQALWKEP . :... ::.. : : . : : :: :: .. . ....: : NP_004 TVEVEIQRLLGKVCDRGWGLKEADVVCRQ----LG-CGSALKTSYQVYSKIQATNTWLFL 390 400 410 420 430 190 200 210 220 230 240 pF1KB5 GSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKLASAYGARQLQGYCASLFAI NP_004 SSCNGNETSLWDCKNWQWGGLTCDHYEEAKITCSAHREPRLVGGDIPCSGRVEVKHGDTW 440 450 460 470 480 490 >>XP_016875720 (OMIM: 605545) PREDICTED: scavenger recep (1161 aa) initn: 720 init1: 459 opt: 462 Z-score: 532.0 bits: 109.4 E(85289): 6.8e-23 Smith-Waterman score: 462; 47.3% identity (76.0% similar) in 129 aa overlap (19-147:714-842) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTV ...:..::..::. :::::...:.:::. XP_016 GNQSQTLSSCNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGRCAGRVEIYHEGSWGTI 690 700 710 720 730 740 50 60 70 80 90 100 pF1KB5 CDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGW ::. :::.:: :::: :: .: .: : : ::.:.::: :::..:.: :. . .:.: :: XP_016 CDDSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMKCNGKESRIWQCHSHGW 750 760 770 780 790 800 110 120 130 140 150 160 pF1KB5 LKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALG ..::::..::::.:.. : . ::: . ..: XP_016 GQQNCRHKEDAGVICSEFMSLRLTSEASREACAGRLEVFYNGAWGTVGKSSMSETTVGVV 810 820 830 840 850 860 170 180 190 200 210 220 pF1KB5 FCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFH XP_016 CRQLGCADKGKINPASLDKAMSIPMWVDNVQCPKGPDTLWQCPSSPWEKRLASPSEETWI 870 880 890 900 910 920 >-- initn: 414 init1: 399 opt: 399 Z-score: 459.0 bits: 95.9 E(85289): 8e-19 Smith-Waterman score: 399; 52.4% identity (78.1% similar) in 105 aa overlap (21-125:926-1030) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCD :. .:: .: .. .:::::.. :.:::::: XP_016 PKGPDTLWQCPSSPWEKRLASPSEETWITCDNKIRLQEGPTSCSGRVEIWHGGSWGTVCD 900 910 920 930 940 950 60 70 80 90 100 110 pF1KB5 NLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLK . ::: ::.:::. :: : .:. .: ::::.::: :.::.: :.:.:: :: . : . XP_016 DSWDLDDAQVVCQQLGCGPALKAFKEAEFGQGTGPIWLNEVKCKGNESSLWDCPARRWGH 960 970 980 990 1000 1010 120 130 140 150 160 170 pF1KB5 SNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFC :.: :..::.: ::. XP_016 SECGHKEDAAVNCTDISVQKTPQKATTGRSSRQSSFIAVGILGVVLLAIFVALFFLTKKR 1020 1030 1040 1050 1060 1070 >-- initn: 1007 init1: 373 opt: 385 Z-score: 442.7 bits: 92.9 E(85289): 6.4e-18 Smith-Waterman score: 385; 42.6% identity (68.1% similar) in 141 aa overlap (20-154:152-292) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG---DMRLADGGATNQGRVEIFYRGQWG .:: .:::. :: .::.:: ..:.:: XP_016 GNESALWDCKHDGWGKHSNCTHQQDAGVTCSDGSNLEMRLTRGGNMCSGRIEIKFQGRWG 130 140 150 160 170 180 50 60 70 80 90 100 pF1KB5 TVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSL ::::. ... :::.:: : .:.. : . ::.::::: .:.. :.:.:..: .:: XP_016 TVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICNGNESALWNCKHQ 190 200 210 220 230 240 110 120 130 140 150 160 pF1KB5 GWLKSNCRHERDAGVVCTNETR-STHTLDLSRELSEALGQIFDSQRG--CDLSISVNVQG :: : :: : .::::.:.. . : . .: : : : :... : :: XP_016 GWGKHNCDHAEDAGVICSKGADLSLRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAA 250 260 270 280 290 300 170 180 190 200 210 220 pF1KB5 EDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSS XP_016 VACKQLGCPTAVTAIGRVNASKGFGHIWLDSVSCQGHEPAIWQCKHHEWGKHYCNHNEDA 310 320 330 340 350 360 >-- initn: 350 init1: 274 opt: 360 Z-score: 413.7 bits: 87.5 E(85289): 2.6e-16 Smith-Waterman score: 360; 43.8% identity (68.0% similar) in 128 aa overlap (1-123:24-151) 10 20 30 pF1KB5 MTPPRLFWVWLL----VAGTQGVNDGDMRLADGGATN ..: . : :: :... : .: ..::.:: XP_016 MSKLRMVLLEDSGSADFRRHFVNLSPFTITVVLLLSACFVTSSLGGTDKELRLVDGENKC 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 QGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQC .::::. . .:::::.: :.. .::.: :: .: .: : : . ::: : .:.:.: XP_016 SGRVEVKVQEEWGTVCNNGWSMEAVSVICNQLGCPTAIKAPGWANSSAGSGRIWMDHVSC 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB5 TGTEASLADCKSLGWLK-SNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRG :.:..: ::: :: : ::: :..::::.: XP_016 RGNESALWDCKHDGWGKHSNCTHQQDAGVTCSDGSNLEMRLTRGGNMCSGRIEIKFQGRW 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB5 CDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYF XP_016 GTVCDDNFNIDHASVICRQLECGSAVSFSGSSNFGEGSGPIWFDDLICNGNESALWNCKH 190 200 210 220 230 240 >-- initn: 537 init1: 279 opt: 279 Z-score: 319.8 bits: 70.1 E(85289): 4.5e-11 Smith-Waterman score: 279; 40.8% identity (64.1% similar) in 103 aa overlap (25-127:479-581) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWD ::. : .::::. . ::..::. .. XP_016 LWDCKNWQWGGLTCDHYEEAKITCSAHREPRLVGGDIPCSGRVEVKHGDTWGSICDSDFS 450 460 470 480 490 500 60 70 80 90 100 110 pF1KB5 LTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCR : :::.:: : .... :: : ::.:.: : .: :: : :. :. : ...: XP_016 LEAASVLCRELQCGTVVSILGGAHFGEGNGQIWAEEFQCEGHESHLSLCPVAPRPEGTCS 510 520 530 540 550 560 120 130 140 150 160 170 pF1KB5 HERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTV : ::.::::. : XP_016 HSRDVGVVCSRYTEIRLVNGKTPCEGRVELKTLGAWGSLCNSHWDIEDAHVLCQQLKCGV 570 580 590 600 610 620 >-- initn: 257 init1: 237 opt: 273 Z-score: 312.8 bits: 68.8 E(85289): 1.1e-10 Smith-Waterman score: 273; 36.9% identity (61.5% similar) in 122 aa overlap (23-144:582-699) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNL ..::..: . .::::. : ::..:.. XP_016 SHLSLCPVAPRPEGTCSHSRDVGVVCSRYTEIRLVNGKTPCEGRVELKTLGAWGSLCNSH 560 570 580 590 600 610 60 70 80 90 100 110 pF1KB5 WDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSN ::. :: :.:. : : .. : : ::.:.: : .::::: ..:: . : XP_016 WDIEDAHVLCQQLKCGVALSTPGGARFGKGNGQIWRHMFHCTGTEQHMGDCPVTALGASL 620 630 640 650 660 670 120 130 140 150 160 170 pF1KB5 CRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH : :. :.:.:... .: :: : .:: XP_016 CPSEQVASVICSGNQSQT----LSSCNSSSLGPTRPTIPEESAVACIESGQLRLVNGGGR 680 690 700 710 720 180 190 200 210 220 230 pF1KB5 TVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKLAS XP_016 CAGRVEIYHEGSWGTICDDSWDLSDAHVVCRQLGCGEAINATGSAHFGEGTGPIWLDEMK 730 740 750 760 770 780 >-- initn: 270 init1: 232 opt: 234 Z-score: 267.6 bits: 60.5 E(85289): 3.6e-08 Smith-Waterman score: 234; 32.7% identity (55.1% similar) in 147 aa overlap (53-186:295-436) 30 40 50 60 70 80 pF1KB5 DMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQG :: ::.:.:. :: .:. :.::. ..: XP_016 SLRLVDGVTECSGRLEVRFQGEWGTICDDGWDSYDAAVACKQLGCPTAVTAIGRVNASKG 270 280 290 300 310 320 90 100 110 120 130 pF1KB5 SGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCTN----ETR-----STHTL : : :: :.: : : .. .:: : : : :..::::.:.. : : : . XP_016 FGHIWLDSVSCQGHEPAIWQCKHHEWGKHYCNHNEDAGVTCSDGSDLELRLRGGGSRCAG 330 340 350 360 370 380 140 150 160 170 180 pF1KB5 DLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILT----ANLEAQALWKEP . :... ::.. : : . : : :: :: .. . ....: : XP_016 TVEVEIQRLLGKVCDRGWGLKEADVVCRQ----LG-CGSALKTSYQVYSKIQATNTWLFL 390 400 410 420 430 190 200 210 220 230 240 pF1KB5 GSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKLASAYGARQLQGYCASLFAI XP_016 SSCNGNETSLWDCKNWQWGGLTCDHYEEAKITCSAHREPRLVGGDIPCSGRVEVKHGDTW 440 450 460 470 480 490 >>NP_060049 (OMIM: 601969) deleted in malignant brain tu (2403 aa) initn: 3884 init1: 454 opt: 463 Z-score: 528.7 bits: 109.8 E(85289): 1e-22 Smith-Waterman score: 463; 51.0% identity (70.6% similar) in 143 aa overlap (24-163:363-503) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: :::::..:::.::::::. : NP_060 CSAPQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSW 340 350 360 370 380 390 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: :::. :: NP_060 DTSDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNC 400 410 420 430 440 450 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTNETRSTHTLDLSR---ELSEALGQIFDSQRGCDLSISVNVQGEDALGFC .: .::::.:.. : : :: : : : :: . ..: :. . : .: NP_060 QHSEDAGVICSD-TLPTITLPASTVGSESSLALRLVNGGDR-CQGRVEVLYRGSWGTVCD 460 470 480 490 500 510 180 190 200 210 220 230 pF1KB5 GHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSVKCFHKL NP_060 DSWDTNDANVVCRQLGCGWAMLAPGNARFGQGSGPIVLDDVRCSGNESYLWSCPHNGWLS 520 530 540 550 560 570 >-- initn: 868 init1: 446 opt: 458 Z-score: 522.9 bits: 108.8 E(85289): 2.2e-22 Smith-Waterman score: 458; 57.1% identity (78.6% similar) in 112 aa overlap (24-134:592-703) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: :::::..:::.::::::. : NP_060 SCPHNGWLSHNCGHSEDAGVICSGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSW 570 580 590 600 610 620 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: . :::. :: NP_060 DTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPNNGWLSHNC 630 640 650 660 670 680 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTN-ETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH :..::::.:. ..::: : NP_060 GHHEDAGVICSAAQSRSTPRPDTLSTITLPPSTVGSESSLTLRLVNGSDRCQGRVEVLYR 690 700 710 720 730 740 >-- initn: 2151 init1: 452 opt: 452 Z-score: 515.9 bits: 107.5 E(85289): 5.4e-22 Smith-Waterman score: 452; 59.4% identity (80.2% similar) in 101 aa overlap (24-124:852-952) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: :::::..:::.::::::. : NP_060 CSVSQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSW 830 840 850 860 870 880 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: :::. :: NP_060 DTSDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNC 890 900 910 920 930 940 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHT .: .::::.:. NP_060 QHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNGGDRCQGRVEVLYQ 950 960 970 980 990 1000 >-- initn: 492 init1: 449 opt: 452 Z-score: 515.9 bits: 107.5 E(85289): 5.4e-22 Smith-Waterman score: 452; 52.8% identity (77.2% similar) in 123 aa overlap (14-134:1230-1352) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYR :.: : ... .::..:: :::::..:: NP_060 NCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYR 1200 1210 1220 1230 1240 1250 50 60 70 80 90 100 pF1KB5 GQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLAD :.::::::. :: .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : . NP_060 GSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1260 1270 1280 1290 1300 1310 110 120 130 140 150 160 pF1KB5 CKSLGWLKSNCRHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNV : :::. :: :..::::.:. .... : . : NP_060 CPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRC 1320 1330 1340 1350 1360 1370 170 180 190 200 210 220 pF1KB5 QGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITL NP_060 QGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRC 1380 1390 1400 1410 1420 1430 >-- initn: 492 init1: 449 opt: 452 Z-score: 515.9 bits: 107.5 E(85289): 5.4e-22 Smith-Waterman score: 452; 52.8% identity (77.2% similar) in 123 aa overlap (14-134:1359-1481) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYR :.: : ... .::..:: :::::..:: NP_060 NCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYR 1330 1340 1350 1360 1370 1380 50 60 70 80 90 100 pF1KB5 GQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLAD :.::::::. :: .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : . NP_060 GSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1390 1400 1410 1420 1430 1440 110 120 130 140 150 160 pF1KB5 CKSLGWLKSNCRHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNV : :::. :: :..::::.:. .... : . : NP_060 CPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSRASTAGSESTLALRLVNGGDRC 1450 1460 1470 1480 1490 1500 170 180 190 200 210 220 pF1KB5 QGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITL NP_060 RGRVEVLYQGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQFGQGSGPIVLDDVRC 1510 1520 1530 1540 1550 1560 >-- initn: 472 init1: 436 opt: 447 Z-score: 510.1 bits: 106.4 E(85289): 1.1e-21 Smith-Waterman score: 447; 55.4% identity (78.6% similar) in 112 aa overlap (24-134:723-834) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:. :::::..:::.::::::. : NP_060 AAQSRSTPRPDTLSTITLPPSTVGSESSLTLRLVNGSDRCQGRVEVLYRGSWGTVCDDSW 700 710 720 730 740 750 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: ::.: : : ::::::::.::.:.:.: :. : .: :::. :: NP_060 DTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNC 760 770 780 790 800 810 120 130 140 150 160 170 pF1KB5 RHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH :..::::.:. ...: : . : NP_060 GHHEDAGVICSVSQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGS 820 830 840 850 860 870 >-- initn: 909 init1: 443 opt: 446 Z-score: 508.9 bits: 106.2 E(85289): 1.3e-21 Smith-Waterman score: 446; 52.0% identity (76.4% similar) in 123 aa overlap (14-134:1101-1223) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYR :.: : ... .::..:: :::::..:: NP_060 NCGHSEDAGVICSASQSRPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYR 1080 1090 1100 1110 1120 1130 50 60 70 80 90 100 pF1KB5 GQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLAD :.::::::. :: .::.:::: :: : .: : : ::::::::.::.:.:.: :. : . NP_060 GSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSGHESYLWS 1140 1150 1160 1170 1180 1190 110 120 130 140 150 160 pF1KB5 CKSLGWLKSNCRHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNV : :::. :: :..::::.:. .... : . : NP_060 CPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRC 1200 1210 1220 1230 1240 1250 170 180 190 200 210 220 pF1KB5 QGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITL NP_060 QGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRC 1260 1270 1280 1290 1300 1310 >-- initn: 480 init1: 431 opt: 446 Z-score: 508.9 bits: 106.2 E(85289): 1.3e-21 Smith-Waterman score: 446; 50.0% identity (72.8% similar) in 136 aa overlap (2-134:959-1094) 10 20 pF1KB5 MTP-PRLFWVWLLVAGTQGVNDG-DMRLADG :: : . . : :.: : ... .::..: NP_060 WSCPHNGWLSHNCQHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNG 930 940 950 960 970 980 30 40 50 60 70 80 pF1KB5 GATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLD : :::::..:.:.::::::. :: .::.:::: :: : .: : : ::::::::.:: NP_060 GDRCQGRVEVLYQGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLD 990 1000 1010 1020 1030 1040 90 100 110 120 130 140 pF1KB5 EVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCT-NETRSTHTLDLSRELSEALGQIFD .:.:.: :. : .: :::. :: : .::::.:. ...: : . : NP_060 DVRCSGHESYLWSCPHNGWLSHNCGHSEDAGVICSASQSRPTPSPDTWPTSHASTAGSES 1050 1060 1070 1080 1090 1100 150 160 170 180 190 200 pF1KB5 SQRGCDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDL NP_060 SLALRLVNGGDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNARFG 1110 1120 1130 1140 1150 1160 >-- initn: 486 init1: 443 opt: 444 Z-score: 506.6 bits: 105.7 E(85289): 1.8e-21 Smith-Waterman score: 444; 51.2% identity (72.1% similar) in 129 aa overlap (10-134:1612-1740) 10 20 30 pF1KB5 MTPPRLFWVWL---LVAGTQGVNDG-DMRLADGGATNQG :: : : : : ... .::..:: .: NP_060 GWLSHNCGHHEDAGVICSAAQSQSTPRPDTWLTTNLPALTVGSESSLALRLVNGGDRCRG 1590 1600 1610 1620 1630 1640 40 50 60 70 80 90 pF1KB5 RVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTG :::..:::.::::::. :: .::.:::: :: : .: : : ::::::::.::.:.:.: NP_060 RVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSG 1650 1660 1670 1680 1690 1700 100 110 120 130 140 150 pF1KB5 TEASLADCKSLGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDL .:. : .: ::: :: :..::::.:. .. : : NP_060 NESYLWSCPHKGWLTHNCGHHEDAGVICSATQINSTTTDWWHPTTTTTARPSSNCGGFLF 1710 1720 1730 1740 1750 1760 160 170 180 190 200 210 pF1KB5 SISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSR NP_060 YASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSL 1770 1780 1790 1800 1810 1820 >-- initn: 469 init1: 433 opt: 442 Z-score: 504.3 bits: 105.3 E(85289): 2.4e-21 Smith-Waterman score: 442; 54.5% identity (75.0% similar) in 112 aa overlap (24-134:234-345) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: .::::..:::.::::::. : NP_060 AQPQSTLRPESWPVRISPPVPTEGSESSLALRLVNGGDRCRGRVEVLYRGSWGTVCDDYW 210 220 230 240 250 260 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: : .: : : ::::::::.::.:.:.: :. : .: ::: :: NP_060 DTNDANVVCRQLGCGWAMSAPGNAQFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLTHNC 270 280 290 300 310 320 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTN-ETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH : .::::.:. ..: : . : NP_060 GHSEDAGVICSAPQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGS 330 340 350 360 370 380 >-- initn: 461 init1: 429 opt: 435 Z-score: 496.2 bits: 103.8 E(85289): 6.7e-21 Smith-Waterman score: 435; 53.6% identity (76.8% similar) in 112 aa overlap (24-134:1499-1610) 10 20 30 40 50 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLW .::..:: .::::..:.:.::::::. : NP_060 CSASQSQPTPSPDTWPTSRASTAGSESTLALRLVNGGDRCRGRVEVLYQGSWGTVCDDYW 1470 1480 1490 1500 1510 1520 60 70 80 90 100 110 pF1KB5 DLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNC : .::.:::: :: : .: : : ::::::::.::.:.:.: :. : .: :::. :: NP_060 DTNDANVVCRQLGCGWAMSAPGNAQFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNC 1530 1540 1550 1560 1570 1580 120 130 140 150 160 170 pF1KB5 RHERDAGVVCTN-ETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGH :..::::.:. ...:: : NP_060 GHHEDAGVICSAAQSQSTPRPDTWLTTNLPALTVGSESSLALRLVNGGDRCRGRVEVLYR 1590 1600 1610 1620 1630 1640 >-- initn: 467 init1: 426 opt: 433 Z-score: 493.9 bits: 103.4 E(85289): 9.1e-21 Smith-Waterman score: 433; 56.0% identity (76.1% similar) in 109 aa overlap (17-124:94-202) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDG-DMRLADGGATNQGRVEIFYRGQW .: ..: .::..: . ::::::.:::.: NP_060 SPISLESTLESTVAEGSLIPSESTLESTVAEGSDSGLALRLVNGDGRCQGRVEILYRGSW 70 80 90 100 110 120 50 60 70 80 90 100 pF1KB5 GTVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKS :::::. :: .::.:::: :: : .: : : :::::::: ::.:.:.: :. : .: NP_060 GTVCDDSWDTNDANVVCRQLGCGWAMSAPGNAWFGQGSGPIALDDVRCSGHESYLWSCPH 130 140 150 160 170 180 110 120 130 140 150 160 pF1KB5 LGWLKSNCRHERDAGVVCTNETRSTHTLDLSRELSEALGQIFDSQRGCDLSISVNVQGED :::. :: : .::::.:. NP_060 NGWLSHNCGHGEDAGVICSAAQPQSTLRPESWPVRISPPVPTEGSESSLALRLVNGGDRC 190 200 210 220 230 240 >-- initn: 404 init1: 404 opt: 420 Z-score: 478.8 bits: 100.6 E(85289): 6.3e-20 Smith-Waterman score: 420; 44.4% identity (72.5% similar) in 142 aa overlap (20-156:1869-2010) 10 20 30 40 pF1KB5 MTPPRLFWVWLLVAGTQGVNDGDMRLADGGATN---QGRVEIFYRGQWG .:. .::.. ... :::::.. : :: NP_060 TSSYNRMTIHFRSDISFQNTGFLAWYNSFPSDATLRLVNLNSSYGLCAGRVEIYHGGTWG 1840 1850 1860 1870 1880 1890 50 60 70 80 90 100 pF1KB5 TVCDNLWDLTDASVVCRALGFENATQALGRAAFGQGSGPIMLDEVQCTGTEASLADCKSL ::::. : . .: :::: :: :..::: : ::.::::: ::.:.:.:::..: .:.. NP_060 TVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLDDVECSGTESTLWQCRNR 1900 1910 1920 1930 1940 1950 110 120 130 140 150 160 pF1KB5 GWLKSNCRHERDAGVVCTNETRSTHT--LDLSRELSEALGQIFDSQRGCDLSISVNVQGE ::.. :: :..::::.:... :: . :...: .. : :: . :.: NP_060 GWFSHNCNHREDAGVICSGNHLSTPAPFLNITRPNTDYSCGGFLSQPSGDFSSPFYPGNY 1960 1970 1980 1990 2000 2010 170 180 190 200 210 220 pF1KB5 DALGFCGHTVILTANLEAQALWKEPGSNVTMSVDAECVPMVRDLLRYFYSRRIDITLSSV NP_060 PNNAKCVWDIEVQNNYRVTVIFRDVQLEGGCNYDYIEVFDGPYRSSPLIARVCDGARGSF 2020 2030 2040 2050 2060 2070 >-- initn: 375 init1: 353 opt: 353 Z-score: 401.1 bits: 86.2 E(85289): 1.3e-15 Smith-Waterman score: 353; 56.5% identity (74.1% similar) in 85 aa overlap (45-129:505-589) 20 30 40 50 60 70 pF1KB5 GTQGVNDGDMRLADGGATNQGRVEIFYRGQWGTVCDNLWDLTDASVVCRALGFENATQAL ::::::. :: .::.:::: :: : : NP_060 TVGSESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMLAP 480 490 500 510 520 530 80 90 100 110 120 130 pF1KB5 GRAAFGQGSGPIMLDEVQCTGTEASLADCKSLGWLKSNCRHERDAGVVCTNETRSTHTLD : : ::::::::.::.:.:.:.:. : .: :::. :: : .::::.:.. : NP_060 GNARFGQGSGPIVLDDVRCSGNESYLWSCPHNGWLSHNCGHSEDAGVICSGPESSLALRL 540 550 560 570 580 590 140 150 160 170 180 190 pF1KB5 LSRELSEALGQIFDSQRGCDLSISVNVQGEDALGFCGHTVILTANLEAQALWKEPGSNVT NP_060 VNGGDRCQGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPI 600 610 620 630 640 650 585 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 22:25:48 2016 done: Fri Nov 4 22:25:49 2016 Total Scan time: 8.900 Total Display time: 0.310 Function used was FASTA [36.3.4 Apr, 2011]