FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5068, 547 aa 1>>>pF1KB5068 547 - 547 aa - 547 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1827+/-0.000376; mu= 14.7078+/- 0.023 mean_var=84.8560+/-16.805, 0's: 0 Z-trim(114.7): 116 B-trim: 0 in 0/50 Lambda= 0.139230 statistics sampled from 24652 (24768) to 24652 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.647), E-opt: 0.2 (0.29), width: 16 Scan time: 11.220 The best scores are: opt bits E(85289) NP_061955 (OMIM: 608023) probable ATP-dependent RN ( 547) 3588 730.7 2.7e-210 NP_001244118 (OMIM: 608023) probable ATP-dependent ( 507) 1887 389.0 1.8e-107 NP_060365 (OMIM: 616621) probable ATP-dependent RN ( 796) 581 126.8 2.5e-28 XP_011527190 (OMIM: 616621) PREDICTED: probable AT ( 827) 489 108.3 9.5e-23 NP_006764 (OMIM: 606355) ATP-dependent RNA helicas ( 670) 467 103.9 1.7e-21 XP_016879601 (OMIM: 613369) PREDICTED: ATP-depende ( 775) 452 100.9 1.5e-20 NP_031398 (OMIM: 613369) ATP-dependent RNA helicas ( 938) 452 100.9 1.8e-20 NP_987095 (OMIM: 613369) ATP-dependent RNA helicas ( 938) 452 100.9 1.8e-20 XP_006721720 (OMIM: 613369) PREDICTED: ATP-depende ( 938) 452 100.9 1.8e-20 XP_016879600 (OMIM: 613369) PREDICTED: ATP-depende ( 938) 452 100.9 1.8e-20 NP_076977 (OMIM: 611665) ATP-dependent RNA helicas ( 881) 444 99.3 5.3e-20 NP_001104792 (OMIM: 611665) ATP-dependent RNA heli ( 882) 444 99.3 5.3e-20 NP_004389 (OMIM: 601235) probable ATP-dependent RN ( 875) 436 97.7 1.6e-19 XP_011522561 (OMIM: 613369) PREDICTED: ATP-depende ( 674) 414 93.2 2.7e-18 NP_001278405 (OMIM: 612500) probable ATP-dependent ( 491) 409 92.2 4.2e-18 XP_011522534 (OMIM: 612500) PREDICTED: probable AT ( 581) 409 92.2 4.8e-18 NP_008941 (OMIM: 612500) probable ATP-dependent RN ( 599) 409 92.2 4.9e-18 NP_004809 (OMIM: 612172) probable ATP-dependent RN ( 820) 402 90.9 1.7e-17 NP_001160006 (OMIM: 605281) probable ATP-dependent ( 575) 391 88.6 5.8e-17 XP_011541799 (OMIM: 605281) PREDICTED: probable AT ( 678) 391 88.6 6.7e-17 NP_619526 (OMIM: 616533) probable ATP-dependent RN ( 585) 390 88.4 6.8e-17 NP_001136021 (OMIM: 605281) probable ATP-dependent ( 690) 391 88.6 6.8e-17 XP_011541797 (OMIM: 605281) PREDICTED: probable AT ( 698) 391 88.6 6.9e-17 NP_001160005 (OMIM: 605281) probable ATP-dependent ( 704) 391 88.6 6.9e-17 NP_077726 (OMIM: 605281) probable ATP-dependent RN ( 724) 391 88.6 7.1e-17 XP_006717299 (OMIM: 616533) PREDICTED: probable AT ( 691) 390 88.4 7.8e-17 XP_011517224 (OMIM: 616533) PREDICTED: probable AT ( 691) 390 88.4 7.8e-17 NP_001309269 (OMIM: 616533) probable ATP-dependent ( 778) 390 88.4 8.7e-17 XP_011517223 (OMIM: 616533) PREDICTED: probable AT ( 787) 390 88.4 8.8e-17 NP_073616 (OMIM: 616533) probable ATP-dependent RN ( 851) 390 88.5 9.4e-17 NP_001317367 (OMIM: 607663) ATP-dependent RNA heli ( 369) 369 84.1 8.5e-16 NP_057439 (OMIM: 615428) probable ATP-dependent RN ( 455) 364 83.1 2e-15 NP_065147 (OMIM: 606181) ATP-dependent RNA helicas ( 859) 350 80.4 2.5e-14 NP_004631 (OMIM: 142560) spliceosome RNA helicase ( 428) 335 77.3 1.1e-13 NP_542165 (OMIM: 142560) spliceosome RNA helicase ( 428) 335 77.3 1.1e-13 NP_060850 (OMIM: 607618) probable ATP-dependent RN ( 540) 310 72.3 4.4e-12 NP_957518 (OMIM: 615428) probable ATP-dependent RN ( 406) 298 69.8 1.8e-11 NP_001244120 (OMIM: 600326) probable ATP-dependent ( 483) 290 68.2 6.4e-11 NP_004388 (OMIM: 600326) probable ATP-dependent RN ( 483) 290 68.2 6.4e-11 XP_005271474 (OMIM: 600326) PREDICTED: probable AT ( 483) 290 68.2 6.4e-11 XP_016872740 (OMIM: 600326) PREDICTED: probable AT ( 440) 288 67.8 7.8e-11 XP_011540946 (OMIM: 600326) PREDICTED: probable AT ( 440) 288 67.8 7.8e-11 NP_001191439 (OMIM: 602641) eukaryotic initiation ( 347) 278 65.8 2.6e-10 NP_001407 (OMIM: 602641) eukaryotic initiation fac ( 406) 278 65.8 2.9e-10 NP_001958 (OMIM: 601102) eukaryotic initiation fac ( 407) 266 63.4 1.6e-09 NP_009173 (OMIM: 605812) ATP-dependent RNA helicas ( 479) 260 62.2 4.2e-09 XP_011521136 (OMIM: 605812) PREDICTED: ATP-depende ( 484) 260 62.2 4.2e-09 XP_011521134 (OMIM: 605812) PREDICTED: ATP-depende ( 539) 260 62.2 4.6e-09 XP_016872399 (OMIM: 606357) PREDICTED: nucleolar R ( 661) 258 61.9 7.2e-09 XP_011538638 (OMIM: 606357) PREDICTED: nucleolar R ( 729) 258 61.9 7.9e-09 >>NP_061955 (OMIM: 608023) probable ATP-dependent RNA he (547 aa) initn: 3588 init1: 3588 opt: 3588 Z-score: 3896.4 bits: 730.7 E(85289): 2.7e-210 Smith-Waterman score: 3588; 100.0% identity (100.0% similar) in 547 aa overlap (1-547:1-547) 10 20 30 40 50 60 pF1KB5 MEDSEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 MEDSEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 YAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKELARQAQSMIQQLATYCARDVRVANVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 YAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKELARQAQSMIQQLATYCARDVRVANVSA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLFSFGFEEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 AEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLFSFGFEEEL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 KSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPGPDQLQQFQVVCET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 KSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPGPDQLQQFQVVCET 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 EEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 EEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 ISQFNQGFYDCVIATDAEVLGAPVKGKRRGRGPKGDKASDPEAGVARGIDFHHVSAVLNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 ISQFNQGFYDCVIATDAEVLGAPVKGKRRGRGPKGDKASDPEAGVARGIDFHHVSAVLNF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 DLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIEELLSGENRGPILLPYQFRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 DLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIEELLSGENRGPILLPYQFRM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 EEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 EEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 HPAVVKPHLGHVPDYLVPPALRGLVRPHKKRKKLSSSCRKAKRAKSQNPLRSFKHKGKKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 HPAVVKPHLGHVPDYLVPPALRGLVRPHKKRKKLSSSCRKAKRAKSQNPLRSFKHKGKKF 490 500 510 520 530 540 pF1KB5 RPTAKPS ::::::: NP_061 RPTAKPS >>NP_001244118 (OMIM: 608023) probable ATP-dependent RNA (507 aa) initn: 1887 init1: 1887 opt: 1887 Z-score: 2050.3 bits: 389.0 E(85289): 1.8e-107 Smith-Waterman score: 3214; 92.7% identity (92.7% similar) in 547 aa overlap (1-547:1-507) 10 20 30 40 50 60 pF1KB5 MEDSEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEDSEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 YAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKELARQAQSMIQQLATYCARDVRVANVSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKELARQAQSMIQQLATYCARDVRVANVSA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLFSFGFEEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLFSFGFEEEL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 KSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPGPDQLQQFQVVCET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPGPDQLQQFQVVCET 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 EEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSR--- 250 260 270 280 290 310 320 330 340 350 360 pF1KB5 ISQFNQGFYDCVIATDAEVLGAPVKGKRRGRGPKGDKASDPEAGVARGIDFHHVSAVLNF ::::::::::::::::::::::: NP_001 -------------------------------------ASDPEAGVARGIDFHHVSAVLNF 300 310 320 370 380 390 400 410 420 pF1KB5 DLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIEELLSGENRGPILLPYQFRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIEELLSGENRGPILLPYQFRM 330 340 350 360 370 380 430 440 450 460 470 480 pF1KB5 EEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPL 390 400 410 420 430 440 490 500 510 520 530 540 pF1KB5 HPAVVKPHLGHVPDYLVPPALRGLVRPHKKRKKLSSSCRKAKRAKSQNPLRSFKHKGKKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HPAVVKPHLGHVPDYLVPPALRGLVRPHKKRKKLSSSCRKAKRAKSQNPLRSFKHKGKKF 450 460 470 480 490 500 pF1KB5 RPTAKPS ::::::: NP_001 RPTAKPS >>NP_060365 (OMIM: 616621) probable ATP-dependent RNA he (796 aa) initn: 553 init1: 293 opt: 581 Z-score: 629.6 bits: 126.8 E(85289): 2.5e-28 Smith-Waterman score: 660; 28.7% identity (60.5% similar) in 564 aa overlap (5-539:216-742) 10 20 30 pF1KB5 MEDSEALGFEHMGLDPRLLQAVTDLGWSRPTLIQ : :.:. :.:. ::.:.: .:...:: :: NP_060 ADTLKVKDRKKKKKKGQEAGGFFEDASQYDENLSFQDMNLSRPLLKAITAMGFKQPTPIQ 190 200 210 220 230 240 40 50 60 70 80 90 pF1KB5 EKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKEL . ::..: :::. : : ::.:::::.:.:.:. :... .:: .: ::::::.:: NP_060 KACIPVGLLGKDICACAATGTGKTAAFALPVLERLIYKPRQAPV----TRVLVLVPTREL 250 260 270 280 290 300 100 110 120 130 140 150 pF1KB5 ARQAQSMIQQLATYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQ-DS . :..:. .::: .: .. . . .. : ::.:.: ::....::.:...::.. : NP_060 GIQVHSVTRQLAQFC--NITTCLAVGGLDVKSQEAALRAAPDILIATPGRLIDHLHNCPS 310 320 330 340 350 160 170 180 190 200 210 pF1KB5 LKLRDSLELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILH ..: .:.:.:..:::: ... :::..: .. . :..:.:::....:. : . :. NP_060 FHL-SSIEVLILDEADRMLDEYFEEQMKEIIRMCSHHRQTMLFSATMTDEVKDLASVSLK 360 370 380 390 400 410 220 230 240 250 260 270 pF1KB5 NPVTLKLQESQLPGPDQLQQF-QVVCETEEDKFLLLYALLKLSLIRGKSLLFVNTLERSY ::: . .. . .: :.: .. . : :. .. ::: .. . .::..: .... NP_060 NPVRIFVNSNTDVAPFLRQEFIRIRPNREGDREAIVAALLTRTFT-DHVMLFTQTKKQAH 420 430 440 450 460 470 280 290 300 310 320 330 pF1KB5 RLRLFLEQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAEVLGAPVKGKRRGRG :....: ... . :.:.: .: . . .:.. : ..:::. NP_060 RMHILLGLMGLQVGELHGNLSQTQRLEALRRFKDEQIDILVATDV--------------- 480 490 500 510 520 340 350 360 370 380 390 pF1KB5 PKGDKASDPEAGVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPT .:::.:.. :..:.:: .: : . :.::.::::::. : ...: NP_060 ------------AARGLDIEGVKTVINFTMPNTIKHYVHRVGRTARAGRAGRSVSLVGED 530 540 550 560 570 400 410 420 430 440 pF1KB5 EQFHLGKIEELLSGENRGPIL-----LPYQFRMEEIEGFRYRC------RDAMRSVTKQA :. : .: . .. .. :: : .. ..:..: : . :.. : NP_060 ERKMLKEIVKAAKAPVKARILPQDVILKFRDKIEKMEKDVYAVLQLEAEEKEMQQSEAQI 580 590 600 610 620 630 450 460 470 480 490 pF1KB5 IREARLKEIKEELLHSEKLKTYFEDNPRDLQ------LLRHDLPLHPAVVKPHLGHVPDY :: : .: . .: ...:. . . . : . :: :. : . . : NP_060 NTAKRLLEKGKEAVVQEPERSWFQTKEERKKEKIAKALQEFDLALRGK--KKRKKFMKDA 640 650 660 670 680 500 510 520 530 540 pF1KB5 LVPPALRG-------LVRPHKKRKKLSSSCRKAKRAKS---QNPLRSFKHKGKKFRPTAK . . ... . ..:.. :.::::.. ..:.:. .: :. NP_060 KKKGEMTAEERSQFEILKAQMFAERLAKRNRRAKRARAMPEEEPVRGPAKKQKQGKKSVF 690 700 710 720 730 740 pF1KB5 PS NP_060 DEELTNTSKKALKQYRAGPSFEERKQLGLPHQRRGGNFKSKSRYKRRK 750 760 770 780 790 >>XP_011527190 (OMIM: 616621) PREDICTED: probable ATP-de (827 aa) initn: 622 init1: 196 opt: 489 Z-score: 529.4 bits: 108.3 E(85289): 9.5e-23 Smith-Waterman score: 591; 27.6% identity (57.3% similar) in 595 aa overlap (5-539:216-773) 10 20 30 pF1KB5 MEDSEALGFEHMGLDPRLLQAVTDLGWSRPTLIQ : :.:. :.:. ::.:.: .:...:: :: XP_011 ADTLKVKDRKKKKKKGQEAGGFFEDASQYDENLSFQDMNLSRPLLKAITAMGFKQPTPIQ 190 200 210 220 230 240 40 50 60 70 80 90 pF1KB5 EKAIPLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKEL . ::..: :::. : : ::.:::::.:.:.:. :... .:: .: ::::::.:: XP_011 KACIPVGLLGKDICACAATGTGKTAAFALPVLERLIYKPRQAPV----TRVLVLVPTREL 250 260 270 280 290 300 100 110 120 130 140 150 pF1KB5 ARQAQSMIQQLATYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQ-DS . :..:. .::: .: .. . . .. : ::.:.: ::....::.:...::.. : XP_011 GIQVHSVTRQLAQFC--NITTCLAVGGLDVKSQEAALRAAPDILIATPGRLIDHLHNCPS 310 320 330 340 350 160 170 180 pF1KB5 LKLRDSLELLVVDEAD----------------LLFSFG---------------FEEELKS ..: .:.:.:..:::: : . : :::..: XP_011 FHL-SSIEVLILDEADSPPVDTAWPHAPTLWLLHLPFPQPGAISCPFRMLDEYFEEQMKE 360 370 380 390 400 410 190 200 210 220 230 240 pF1KB5 LLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPGPDQLQQF-QVVCETE .. . :..:.:::....:. : . :.::: . .. . .: :.: .. . : XP_011 IIRMCSHHRQTMLFSATMTDEVKDLASVSLKNPVRIFVNSNTDVAPFLRQEFIRIRPNRE 420 430 440 450 460 470 250 260 270 280 290 300 pF1KB5 EDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHII :. .. ::: .. . .::..: ....:....: ... . :.:.: .: . . XP_011 GDREAIVAALLTRTFT-DHVMLFTQTKKQAHRMHILLGLMGLQVGELHGNLSQTQRLEAL 480 490 500 510 520 530 310 320 330 340 350 360 pF1KB5 SQFNQGFYDCVIATDAEVLGAPVKGKRRGRGPKGDKASDPEAGVARGIDFHHVSAVLNFD .:.. : ..:::. .:::.:.. :..:.:: XP_011 RRFKDEQIDILVATDV---------------------------AARGLDIEGVKTVINFT 540 550 560 570 370 380 390 400 410 pF1KB5 LPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIEELLSGENRGPIL-----LPY .: : . :.::.::::::. : ...: :. : .: . .. .. :: : . XP_011 MPNTIKHYVHRVGRTARAGRAGRSVSLVGEDERKMLKEIVKAAKAPVKARILPQDVILKF 580 590 600 610 620 630 420 430 440 450 460 470 pF1KB5 QFRMEEIEGFRYRC------RDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRD . ..:..: : . :.. : :: : .: . .: ...:. . . XP_011 RDKIEKMEKDVYAVLQLEAEEKEMQQSEAQINTAKRLLEKGKEAVVQEPERSWFQTKEER 640 650 660 670 680 690 480 490 500 510 pF1KB5 LQ------LLRHDLPLHPAVVKPHLGHVPDYLVPPALRG-------LVRPHKKRKKLSSS . : . :: :. : . . : . . ... . ..:.. XP_011 KKEKIAKALQEFDLALRGK--KKRKKFMKDAKKKGEMTAEERSQFEILKAQMFAERLAKR 700 710 720 730 740 520 530 540 pF1KB5 CRKAKRAKS---QNPLRSFKHKGKKFRPTAKPS :.::::.. ..:.:. .: :. XP_011 NRRAKRARAMPEEEPVRGPAKKQKQGKKSVFDEELTNTSKKALKQYRAGPSFEERKQLGL 750 760 770 780 790 800 >>NP_006764 (OMIM: 606355) ATP-dependent RNA helicase DD (670 aa) initn: 481 init1: 188 opt: 467 Z-score: 507.0 bits: 103.9 E(85289): 1.7e-21 Smith-Waterman score: 549; 28.5% identity (59.7% similar) in 529 aa overlap (19-539:191-661) 10 20 30 40 pF1KB5 MEDSEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAI-PLALEGKDL :.:. ..:.. : ::.:.: :: :::.:: NP_006 SEVPSLPLGLTGAFEDTSFASLCNLVNENTLKAIKEMGFTNMTEIQHKSIRPL-LEGRDL 170 180 190 200 210 50 60 70 80 90 100 pF1KB5 LARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKELARQAQSMIQQLAT :: :.:::::: :. :: ..:... . : .: :.: ::.::: :. .....: : NP_006 LAAAKTGSGKTLAFLIPAVELIVKLRFM-PRNGTGV--LILSPTRELAMQTFGVLKELMT 220 230 240 250 260 270 110 120 130 140 150 160 pF1KB5 YCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDE . .. . .. ... .:. : . ...:.::.:.:.:.:. . .:. ::.:: NP_006 HHVHTYGLIMGGSNRSAEAQK--LGNGINIIVATPGRLLDHMQNTPGFMYKNLQCLVIDE 280 290 300 310 320 330 170 180 190 200 210 220 pF1KB5 ADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHN-PVTLKLQESQLP :: ... :::::::... :: :..:.::: .. :. : .. :.. :. . ..... NP_006 ADRILDVGFEEELKQIIKLLPTRRQTMLFSATQTRKVEDLARISLKKEPLYVGVDDDKAN 340 350 360 370 380 390 230 240 250 260 270 280 pF1KB5 GP-DQLQQFQVVCETEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPT . : :.: ::: .:. .::::...:: . . ..: . . .:. .: :. ...:. NP_006 ATVDGLEQGYVVCPSEK-RFLLLFTFLKKNRKKKLMVFFSSCMSVKYHYEL-LNYIDLPV 400 410 420 430 440 450 290 300 310 320 330 340 pF1KB5 CVLNGELPLRSRCHIISQFNQGFYDCVIATDAEVLGAPVKGKRRGRGPKGDKASDPEAGV ...:. .: . :: .. .. ::. . NP_006 LAIHGKQKQNKRTTTFFQFCNADSGTLLCTDV---------------------------A 460 470 480 350 360 370 380 390 400 pF1KB5 ARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARA-NNPGIVLTFVLPTEQFHLGKIEELL :::.:. .:. ....: : :. ::::.:::::. :. : .: .. : : :: .. : NP_006 ARGLDIPEVDWIVQYDPPDDPKEYIHRVGRTARGLNGRGHALLILRPEE---LGFLRYL- 490 500 510 520 530 540 410 420 430 440 450 460 pF1KB5 SGENRGPILLPYQFRMEEIEGFRYRCRDAMRS--VTKQAIREARLKEIKEELLHSEKLKT ... : : ..: .: .. . . ... ... .:: . :. :: :: NP_006 -KQSKVP-LSEFDFSWSKISDIQSQLEKLIEKNYFLHKSAQEAYKSYIRAYDSHS--LKQ 550 560 570 580 590 470 480 490 500 510 520 pF1KB5 YFEDNPRDLQLLRHDLPLHPAVVKPHLGHVPDYLVPPALRGLVRPH--KKRKKLSSSCRK : : .:.: :... . ::: . : . :..:. ... NP_006 IF--NVNNLNL-------------PQVALSFGFKVPPFVDLNVNSNEGKQKKRGGGGGFG 600 610 620 630 640 530 540 pF1KB5 AKRAKSQNPLRSFKHKGKKFRPTAKPS ...:. . . ::: .:: NP_006 YQKTKKVEKSKIFKHISKKSSDSRQFSH 650 660 670 >>XP_016879601 (OMIM: 613369) PREDICTED: ATP-dependent R (775 aa) initn: 384 init1: 148 opt: 452 Z-score: 489.7 bits: 100.9 E(85289): 1.5e-20 Smith-Waterman score: 525; 27.7% identity (59.9% similar) in 401 aa overlap (9-409:92-459) 10 20 30 pF1KB5 MEDSEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAI : :.:.: .:.. . ...:: :: ... XP_016 TNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGV 70 80 90 100 110 120 40 50 60 70 80 90 pF1KB5 PLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKELARQA :.:: :.:... :.::::::::. ::: .. .: : .. .... ::.:: .: XP_016 PVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEP--GDGPIAVIVCPTRELCQQI 130 140 150 160 170 100 110 120 130 140 150 pF1KB5 QSMIQQLATYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRD .. .... : ..: . : .. . : .:.: ..:: ::.:...:... . .:. XP_016 HAECKRFGK--AYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATNLQ- 180 190 200 210 220 230 160 170 180 190 200 210 pF1KB5 SLELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTL . :: :::: .:..::: ...:. :. :..:.:::: . .. : . :: .:. . XP_016 RVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRV 240 250 260 270 280 290 220 230 240 250 260 270 pF1KB5 KLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFL .: . . ... :. . .. .:. : : :. ::::. . .: : XP_016 -VQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNL 300 310 320 330 340 350 280 290 300 310 320 330 pF1KB5 EQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAEVLGAPVKGKRRGRGPKGDKA .: . .:.:.. : ..::.:.. ..:::. XP_016 KQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDV--------------------- 360 370 380 390 340 350 360 370 380 390 pF1KB5 SDPEAGVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLG .:::.:. ...:.:.:. ... :: :::.::.. :.. :.. : .. : XP_016 ------AARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAG 400 410 420 430 440 400 410 420 430 440 450 pF1KB5 KIEELLSGENRGPILLPYQFRMEEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSE . . : : :. XP_016 DLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENM 450 460 470 480 490 500 >>NP_031398 (OMIM: 613369) ATP-dependent RNA helicase DD (938 aa) initn: 384 init1: 148 opt: 452 Z-score: 488.4 bits: 100.9 E(85289): 1.8e-20 Smith-Waterman score: 525; 27.7% identity (59.9% similar) in 401 aa overlap (9-409:255-622) 10 20 30 pF1KB5 MEDSEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAI : :.:.: .:.. . ...:: :: ... NP_031 TNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGV 230 240 250 260 270 280 40 50 60 70 80 90 pF1KB5 PLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKELARQA :.:: :.:... :.::::::::. ::: .. .: : .. .... ::.:: .: NP_031 PVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEP--GDGPIAVIVCPTRELCQQI 290 300 310 320 330 340 100 110 120 130 140 150 pF1KB5 QSMIQQLATYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRD .. .... : ..: . : .. . : .:.: ..:: ::.:...:... . .:. NP_031 HAECKRFGK--AYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATNLQ- 350 360 370 380 390 160 170 180 190 200 210 pF1KB5 SLELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTL . :: :::: .:..::: ...:. :. :..:.:::: . .. : . :: .:. . NP_031 RVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRV 400 410 420 430 440 450 220 230 240 250 260 270 pF1KB5 KLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFL .: . . ... :. . .. .:. : : :. ::::. . .: : NP_031 -VQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNL 460 470 480 490 500 510 280 290 300 310 320 330 pF1KB5 EQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAEVLGAPVKGKRRGRGPKGDKA .: . .:.:.. : ..::.:.. ..:::. NP_031 KQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDV--------------------- 520 530 540 550 340 350 360 370 380 390 pF1KB5 SDPEAGVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLG .:::.:. ...:.:.:. ... :: :::.::.. :.. :.. : .. : NP_031 ------AARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAG 560 570 580 590 600 610 400 410 420 430 440 450 pF1KB5 KIEELLSGENRGPILLPYQFRMEEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSE . . : : :. NP_031 DLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENM 620 630 640 650 660 670 >>NP_987095 (OMIM: 613369) ATP-dependent RNA helicase DD (938 aa) initn: 384 init1: 148 opt: 452 Z-score: 488.4 bits: 100.9 E(85289): 1.8e-20 Smith-Waterman score: 525; 27.7% identity (59.9% similar) in 401 aa overlap (9-409:255-622) 10 20 30 pF1KB5 MEDSEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAI : :.:.: .:.. . ...:: :: ... NP_987 TNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGV 230 240 250 260 270 280 40 50 60 70 80 90 pF1KB5 PLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKELARQA :.:: :.:... :.::::::::. ::: .. .: : .. .... ::.:: .: NP_987 PVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEP--GDGPIAVIVCPTRELCQQI 290 300 310 320 330 340 100 110 120 130 140 150 pF1KB5 QSMIQQLATYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRD .. .... : ..: . : .. . : .:.: ..:: ::.:...:... . .:. NP_987 HAECKRFGK--AYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATNLQ- 350 360 370 380 390 160 170 180 190 200 210 pF1KB5 SLELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTL . :: :::: .:..::: ...:. :. :..:.:::: . .. : . :: .:. . NP_987 RVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRV 400 410 420 430 440 450 220 230 240 250 260 270 pF1KB5 KLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFL .: . . ... :. . .. .:. : : :. ::::. . .: : NP_987 -VQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNL 460 470 480 490 500 510 280 290 300 310 320 330 pF1KB5 EQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAEVLGAPVKGKRRGRGPKGDKA .: . .:.:.. : ..::.:.. ..:::. NP_987 KQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDV--------------------- 520 530 540 550 340 350 360 370 380 390 pF1KB5 SDPEAGVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLG .:::.:. ...:.:.:. ... :: :::.::.. :.. :.. : .. : NP_987 ------AARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAG 560 570 580 590 600 610 400 410 420 430 440 450 pF1KB5 KIEELLSGENRGPILLPYQFRMEEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSE . . : : :. NP_987 DLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENM 620 630 640 650 660 670 >>XP_006721720 (OMIM: 613369) PREDICTED: ATP-dependent R (938 aa) initn: 384 init1: 148 opt: 452 Z-score: 488.4 bits: 100.9 E(85289): 1.8e-20 Smith-Waterman score: 525; 27.7% identity (59.9% similar) in 401 aa overlap (9-409:255-622) 10 20 30 pF1KB5 MEDSEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAI : :.:.: .:.. . ...:: :: ... XP_006 TNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGV 230 240 250 260 270 280 40 50 60 70 80 90 pF1KB5 PLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKELARQA :.:: :.:... :.::::::::. ::: .. .: : .. .... ::.:: .: XP_006 PVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEP--GDGPIAVIVCPTRELCQQI 290 300 310 320 330 340 100 110 120 130 140 150 pF1KB5 QSMIQQLATYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRD .. .... : ..: . : .. . : .:.: ..:: ::.:...:... . .:. XP_006 HAECKRFGK--AYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATNLQ- 350 360 370 380 390 160 170 180 190 200 210 pF1KB5 SLELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTL . :: :::: .:..::: ...:. :. :..:.:::: . .. : . :: .:. . XP_006 RVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRV 400 410 420 430 440 450 220 230 240 250 260 270 pF1KB5 KLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFL .: . . ... :. . .. .:. : : :. ::::. . .: : XP_006 -VQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNL 460 470 480 490 500 510 280 290 300 310 320 330 pF1KB5 EQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAEVLGAPVKGKRRGRGPKGDKA .: . .:.:.. : ..::.:.. ..:::. XP_006 KQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDV--------------------- 520 530 540 550 340 350 360 370 380 390 pF1KB5 SDPEAGVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLG .:::.:. ...:.:.:. ... :: :::.::.. :.. :.. : .. : XP_006 ------AARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAG 560 570 580 590 600 610 400 410 420 430 440 450 pF1KB5 KIEELLSGENRGPILLPYQFRMEEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSE . . : : :. XP_006 DLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENM 620 630 640 650 660 670 >>XP_016879600 (OMIM: 613369) PREDICTED: ATP-dependent R (938 aa) initn: 384 init1: 148 opt: 452 Z-score: 488.4 bits: 100.9 E(85289): 1.8e-20 Smith-Waterman score: 525; 27.7% identity (59.9% similar) in 401 aa overlap (9-409:255-622) 10 20 30 pF1KB5 MEDSEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAI : :.:.: .:.. . ...:: :: ... XP_016 TNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGV 230 240 250 260 270 280 40 50 60 70 80 90 pF1KB5 PLALEGKDLLARARTGSGKTAAYAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKELARQA :.:: :.:... :.::::::::. ::: .. .: : .. .... ::.:: .: XP_016 PVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEP--GDGPIAVIVCPTRELCQQI 290 300 310 320 330 340 100 110 120 130 140 150 pF1KB5 QSMIQQLATYCARDVRVANVSAAEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRD .. .... : ..: . : .. . : .:.: ..:: ::.:...:... . .:. XP_016 HAECKRFGK--AYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATNLQ- 350 360 370 380 390 160 170 180 190 200 210 pF1KB5 SLELLVVDEADLLFSFGFEEELKSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTL . :: :::: .:..::: ...:. :. :..:.:::: . .. : . :: .:. . XP_016 RVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRV 400 410 420 430 440 450 220 230 240 250 260 270 pF1KB5 KLQESQLPGPDQLQQFQVVCETEEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFL .: . . ... :. . .. .:. : : :. ::::. . .: : XP_016 -VQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNL 460 470 480 490 500 510 280 290 300 310 320 330 pF1KB5 EQFSIPTCVLNGELPLRSRCHIISQFNQGFYDCVIATDAEVLGAPVKGKRRGRGPKGDKA .: . .:.:.. : ..::.:.. ..:::. XP_016 KQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDV--------------------- 520 530 540 550 340 350 360 370 380 390 pF1KB5 SDPEAGVARGIDFHHVSAVLNFDLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLG .:::.:. ...:.:.:. ... :: :::.::.. :.. :.. : .. : XP_016 ------AARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAG 560 570 580 590 600 610 400 410 420 430 440 450 pF1KB5 KIEELLSGENRGPILLPYQFRMEEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSE . . : : :. XP_016 DLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENM 620 630 640 650 660 670 547 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 15:53:00 2016 done: Thu Nov 3 15:53:02 2016 Total Scan time: 11.220 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]