FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5078, 857 aa 1>>>pF1KB5078 857 - 857 aa - 857 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8747+/-0.000458; mu= 17.4850+/- 0.028 mean_var=67.9546+/-13.733, 0's: 0 Z-trim(110.1): 51 B-trim: 571 in 1/48 Lambda= 0.155584 statistics sampled from 18363 (18414) to 18363 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.569), E-opt: 0.2 (0.216), width: 16 Scan time: 11.010 The best scores are: opt bits E(85289) NP_036331 (OMIM: 606228) protein argonaute-1 isofo ( 857) 5836 1319.7 0 NP_001304051 (OMIM: 606228) protein argonaute-1 is ( 891) 5836 1319.7 0 XP_011539538 (OMIM: 606228) PREDICTED: protein arg ( 860) 5820 1316.1 0 NP_001304052 (OMIM: 606228) protein argonaute-1 is ( 782) 5320 1203.8 0 XP_016856506 (OMIM: 606228) PREDICTED: protein arg ( 873) 5157 1167.2 0 XP_016856505 (OMIM: 606228) PREDICTED: protein arg ( 876) 5141 1163.7 0 NP_036286 (OMIM: 606229) protein argonaute-2 isofo ( 859) 4926 1115.4 0 XP_011515270 (OMIM: 606229) PREDICTED: protein arg ( 918) 4919 1113.8 0 XP_011515267 (OMIM: 606229) PREDICTED: protein arg ( 873) 4916 1113.1 0 XP_011515268 (OMIM: 606229) PREDICTED: protein arg ( 813) 4803 1087.8 0 XP_016856508 (OMIM: 606228) PREDICTED: protein arg ( 706) 4687 1061.7 0 XP_016868806 (OMIM: 606229) PREDICTED: protein arg ( 782) 4607 1043.8 0 XP_016856012 (OMIM: 607355) PREDICTED: protein arg ( 860) 4508 1021.6 0 NP_079128 (OMIM: 607355) protein argonaute-3 isofo ( 860) 4508 1021.6 0 XP_005270632 (OMIM: 607355) PREDICTED: protein arg ( 860) 4508 1021.6 0 XP_011539181 (OMIM: 607355) PREDICTED: protein arg ( 845) 4492 1018.0 0 NP_001158095 (OMIM: 606229) protein argonaute-2 is ( 825) 4058 920.6 0 XP_016856507 (OMIM: 606228) PREDICTED: protein arg ( 725) 3992 905.7 0 NP_803171 (OMIM: 607355) protein argonaute-3 isofo ( 626) 3903 885.7 0 XP_016856014 (OMIM: 607355) PREDICTED: protein arg ( 626) 3903 885.7 0 XP_016856015 (OMIM: 607355) PREDICTED: protein arg ( 626) 3903 885.7 0 XP_016856016 (OMIM: 607355) PREDICTED: protein arg ( 626) 3903 885.7 0 XP_016856013 (OMIM: 607355) PREDICTED: protein arg ( 626) 3903 885.7 0 XP_011539184 (OMIM: 607355) PREDICTED: protein arg ( 626) 3903 885.7 0 NP_060099 (OMIM: 607356) protein argonaute-4 [Homo ( 861) 3664 832.1 0 XP_005270633 (OMIM: 607355) PREDICTED: protein arg ( 585) 3653 829.6 0 XP_016856017 (OMIM: 607355) PREDICTED: protein arg ( 585) 3653 829.6 0 XP_005270636 (OMIM: 607356) PREDICTED: protein arg ( 794) 3345 760.5 0 XP_005270635 (OMIM: 607356) PREDICTED: protein arg ( 794) 3345 760.5 0 XP_011539185 (OMIM: 607356) PREDICTED: protein arg ( 711) 2938 669.1 1.9e-191 XP_011539186 (OMIM: 607356) PREDICTED: protein arg ( 660) 2596 592.4 2.3e-168 XP_016856018 (OMIM: 607356) PREDICTED: protein arg ( 378) 2114 484.1 5.1e-136 NP_001177900 (OMIM: 605571) piwi-like protein 1 is ( 829) 464 113.8 3.2e-24 XP_016875718 (OMIM: 605571) PREDICTED: piwi-like p ( 832) 464 113.8 3.3e-24 XP_011537308 (OMIM: 605571) PREDICTED: piwi-like p ( 481) 433 106.8 2.5e-22 XP_011537305 (OMIM: 605571) PREDICTED: piwi-like p ( 861) 433 106.9 4.2e-22 NP_004755 (OMIM: 605571) piwi-like protein 1 isofo ( 861) 433 106.9 4.2e-22 XP_011537306 (OMIM: 605571) PREDICTED: piwi-like p ( 861) 433 106.9 4.2e-22 XP_011537304 (OMIM: 605571) PREDICTED: piwi-like p ( 861) 433 106.9 4.2e-22 NP_001129193 (OMIM: 610312) piwi-like protein 2 is ( 973) 419 103.8 4.1e-21 NP_060538 (OMIM: 610312) piwi-like protein 2 isofo ( 973) 419 103.8 4.1e-21 NP_001008496 (OMIM: 610314) piwi-like protein 3 is ( 882) 397 98.8 1.2e-19 NP_689644 (OMIM: 610315) piwi-like protein 4 [Homo ( 852) 374 93.6 4e-18 NP_001242904 (OMIM: 610314) piwi-like protein 3 is ( 873) 368 92.3 1e-17 NP_001317409 (OMIM: 610312) piwi-like protein 2 is ( 937) 351 88.5 1.6e-16 XP_005273608 (OMIM: 610312) PREDICTED: piwi-like p ( 804) 211 57.1 3.9e-07 XP_011537307 (OMIM: 605571) PREDICTED: piwi-like p ( 819) 196 53.7 4.1e-06 >>NP_036331 (OMIM: 606228) protein argonaute-1 isoform 1 (857 aa) initn: 5836 init1: 5836 opt: 5836 Z-score: 7072.2 bits: 1319.7 E(85289): 0 Smith-Waterman score: 5836; 100.0% identity (100.0% similar) in 857 aa overlap (1-857:1-857) 10 20 30 40 50 60 pF1KB5 MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 TMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 TMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 RNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 RNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 MPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 ATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 ATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 AGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 AGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 RIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 RIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB5 RIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 RIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQIL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB5 TYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 TYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQAL 790 800 810 820 830 840 850 pF1KB5 AKAVQVHQDTLRTMYFA ::::::::::::::::: NP_036 AKAVQVHQDTLRTMYFA 850 >>NP_001304051 (OMIM: 606228) protein argonaute-1 isofor (891 aa) initn: 5836 init1: 5836 opt: 5836 Z-score: 7071.9 bits: 1319.7 E(85289): 0 Smith-Waterman score: 5836; 100.0% identity (100.0% similar) in 857 aa overlap (1-857:1-857) 10 20 30 40 50 60 pF1KB5 MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 TMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 RNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 MPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 ATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 AGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 RIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB5 RIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQIL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB5 TYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQAL 790 800 810 820 830 840 850 pF1KB5 AKAVQVHQDTLRTMYFA ::::::::::::::::: NP_001 AKAVQVHQDTLRTMYFAXRQNAVTSLDRRKLSKPQELCHPNPEEARRREVG 850 860 870 880 890 >>XP_011539538 (OMIM: 606228) PREDICTED: protein argonau (860 aa) initn: 2973 init1: 2973 opt: 5820 Z-score: 7052.7 bits: 1316.1 E(85289): 0 Smith-Waterman score: 5820; 99.7% identity (99.7% similar) in 860 aa overlap (1-857:1-860) 10 20 30 40 50 60 pF1KB5 MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 TMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGG 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 R---NRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISK : :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RVSRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISK 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 DAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB5 LGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVT 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB5 HPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRF 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB5 KPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCAD 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB5 KNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADEL 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB5 QILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDP 790 800 810 820 830 840 840 850 pF1KB5 QALAKAVQVHQDTLRTMYFA :::::::::::::::::::: XP_011 QALAKAVQVHQDTLRTMYFA 850 860 >>NP_001304052 (OMIM: 606228) protein argonaute-1 isofor (782 aa) initn: 5320 init1: 5320 opt: 5320 Z-score: 6446.9 bits: 1203.8 E(85289): 0 Smith-Waterman score: 5320; 100.0% identity (100.0% similar) in 782 aa overlap (76-857:1-782) 50 60 70 80 90 100 pF1KB5 DIPKIDVYHYEVDIKPDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALP :::::::::::::::::::::::::::::: NP_001 MVQHFKPQIFGDRKPVYDGKKNIYTVTALP 10 20 30 110 120 130 140 150 160 pF1KB5 IGNERVDFEVTIPGEGKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IGNERVDFEVTIPGEGKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMR 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB5 HLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKA 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB5 QPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRR 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB5 PASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIV 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB5 AGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTE 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB5 VTGRVLPAPILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTGRVLPAPILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVL 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB5 KNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTP 400 410 420 430 440 450 530 540 550 560 570 580 pF1KB5 VYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVF 460 470 480 490 500 510 590 600 610 620 630 640 pF1KB5 QQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVR 520 530 540 550 560 570 650 660 670 680 690 700 pF1KB5 ELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVV 580 590 600 610 620 630 710 720 730 740 750 760 pF1KB5 QKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYV 640 650 660 670 680 690 770 780 790 800 810 820 pF1KB5 LWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEG 700 710 720 730 740 750 830 840 850 pF1KB5 SHISGQSNGRDPQALAKAVQVHQDTLRTMYFA :::::::::::::::::::::::::::::::: NP_001 SHISGQSNGRDPQALAKAVQVHQDTLRTMYFA 760 770 780 >>XP_016856506 (OMIM: 606228) PREDICTED: protein argonau (873 aa) initn: 5157 init1: 5157 opt: 5157 Z-score: 6248.4 bits: 1167.2 E(85289): 0 Smith-Waterman score: 5794; 98.2% identity (98.2% similar) in 873 aa overlap (1-857:1-873) 10 20 30 40 50 60 pF1KB5 MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 TMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 RNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 MPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 ATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 AGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 RIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNE 670 680 690 700 710 720 730 740 750 760 pF1KB5 RIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQ----------------GTSRPSHYY ::::::::::::::::::::::::::::::::::: ::::::::: XP_016 RIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQPSSLPSLGPLTFLSSQGTSRPSHYY 730 740 750 760 770 780 770 780 790 800 810 820 pF1KB5 VLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGE 790 800 810 820 830 840 830 840 850 pF1KB5 GSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA ::::::::::::::::::::::::::::::::: XP_016 GSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA 850 860 870 >>XP_016856505 (OMIM: 606228) PREDICTED: protein argonau (876 aa) initn: 3559 init1: 2870 opt: 5141 Z-score: 6228.9 bits: 1163.7 E(85289): 0 Smith-Waterman score: 5778; 97.8% identity (97.8% similar) in 876 aa overlap (1-857:1-876) 10 20 30 40 50 60 pF1KB5 MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 TMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGG 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 R---NRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISK : :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RVSRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISK 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 DAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB5 LGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVT 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB5 HPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRF 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB5 KPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCAD 670 680 690 700 710 720 720 730 740 750 760 pF1KB5 KNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQ----------------GTSRPS :::::::::::::::::::::::::::::::::::::: :::::: XP_016 KNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQPSSLPSLGPLTFLSSQGTSRPS 730 740 750 760 770 780 770 780 790 800 810 820 pF1KB5 HYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHD 790 800 810 820 830 840 830 840 850 pF1KB5 SGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA :::::::::::::::::::::::::::::::::::: XP_016 SGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA 850 860 870 >>NP_036286 (OMIM: 606229) protein argonaute-2 isoform 1 (859 aa) initn: 4904 init1: 4904 opt: 4926 Z-score: 5968.2 bits: 1115.4 E(85289): 0 Smith-Waterman score: 4926; 83.0% identity (93.9% similar) in 857 aa overlap (3-857:5-859) 10 20 30 40 50 pF1KB5 MEAGPSGAAAGAYLPPLQ-QVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEV :::. : : ::.: .:. : :: .:: :. ::: ::.::.::::::.::::. NP_036 MYSGAGPA-LAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYEL 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 DIKPDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTI ::::.:::::::::.::.:::::: :::::::::.::.::.::. :::: ..:..:::. NP_036 DIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 PGEGKDRIFKVSIKWLAIVSWRMLHEALVSGQIP-VPLESVQALDVAMRHLASMRYTPVG :::::::::::::::.. :: . ::.:: ::..: ::.:..:::::.:::: :::::::: NP_036 PGEGKDRIFKVSIKWVSCVSLQALHDAL-SGRLPSVPFETIQALDVVMRHLPSMRYTPVG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 RSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVL ::::. :: .::::::::::::::::::..:::::::::::::::::::::::.:::: NP_036 RSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 DIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQL :...:.:: :::::::::.:::::::::::.:::::::::::::::::::::::::::: NP_036 DFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQ 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 ESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTD :::::::::::::::....: :.::::::::::::::::::::::::::::::::::::: NP_036 ESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTD 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 NQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPIL :::::::.::::::::::::::.::..::.: :::..:::: :::.::.:::::: : . NP_036 NQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSI 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 QYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKIS :::::.::::: :::::::.:::..:::::::::::::::.:: : ::.::.:::::: NP_036 LYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKIS 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB5 KDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDT .:::::::::::::::::::::::::::::::::.::::..::::::::::::::::::: NP_036 RDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDT 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB5 LLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADV .:::::::::.::: .:.:::::::::::::::::.::::.:. : ::::::::::::: NP_036 VLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADV 540 550 560 570 580 590 600 610 620 630 640 650 pF1KB5 THPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTR :::::::::::::.::::::::::.:::::::::. :::::.::. :::::::::::::: NP_036 THPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTR 600 610 620 630 640 650 660 670 680 690 700 710 pF1KB5 FKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCA ::::::::::::: :::. :.::.::::::.::::::::::::::.:::::::::::::. NP_036 FKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCT 660 670 680 690 700 710 720 730 740 750 760 770 pF1KB5 DKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADE :::::.::::::::::::::.:::: :::::::::::::::::::::.::::::::..:: NP_036 DKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDE 720 730 740 750 760 770 780 790 800 810 820 830 pF1KB5 LQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRD ::::::::::::::::::::::::::::.:::::::::::::::::.:::: :::::::: NP_036 LQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRD 780 790 800 810 820 830 840 850 pF1KB5 PQALAKAVQVHQDTLRTMYFA :::::::::::::::::::: NP_036 HQALAKAVQVHQDTLRTMYFA 840 850 >>XP_011515270 (OMIM: 606229) PREDICTED: protein argonau (918 aa) initn: 4887 init1: 4887 opt: 4919 Z-score: 5959.3 bits: 1113.8 E(85289): 0 Smith-Waterman score: 4919; 82.9% identity (93.8% similar) in 855 aa overlap (5-857:65-918) 10 20 30 pF1KB5 MEAGPSGAAAGAYLPPLQ-QVFQAPRRPGIGTVG : : : ::.: .:. : :: .:: : XP_011 GASTFLRLVLAEHKHKARCQCRAAPCLPSVPIPLAPPAPPPPIQGYAFKPPPRPDFGTSG 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB5 KPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYD . ::: ::.::.::::::.::::.::::.:::::::::.::.:::::: :::::::::.: XP_011 RTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFD 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB5 GKKNIYTVTALPIGNERVDFEVTIPGEGKDRIFKVSIKWLAIVSWRMLHEALVSGQIP-V :.::.::. :::: ..:..:::.:::::::::::::::.. :: . ::.:: ::..: : XP_011 GRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDAL-SGRLPSV 160 170 180 190 200 210 160 170 180 190 200 210 pF1KB5 PLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMM :.:..:::::.:::: ::::::::::::. :: .::::::::::::::::::..:::: XP_011 PFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMM 220 230 240 250 260 270 220 230 240 250 260 270 pF1KB5 LNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQ :::::::::::::::::::.:::::...:.:: :::::::::.:::::::::::.::::: XP_011 LNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQ 280 290 300 310 320 330 280 290 300 310 320 330 pF1KB5 MKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQ ::::::::::::::::::::::: :::::::::::::::....: :.::::::::::::: XP_011 MKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQ 340 350 360 370 380 390 340 350 360 370 380 390 pF1KB5 KHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYI :::::::::::::::::::::::::::::::.::::::::::::::.::..::.: :::. XP_011 KHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYV 400 410 420 430 440 450 400 410 420 430 440 450 pF1KB5 QEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIA .:::: :::.::.:::::: : . :::::.::::: :::::::.:::..:::::::::: XP_011 REFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIA 460 470 480 490 500 510 460 470 480 490 500 510 pF1KB5 CFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSG :::::.:: : ::.::.::::::.:::::::::::::::::::::::::::::::::.: XP_011 CFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAG 520 530 540 550 560 570 520 530 540 550 560 570 pF1KB5 LQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGI :::..:::::::::::::::::::.:::::::::.::: .:.:::::::::::::::::. XP_011 LQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGV 580 590 600 610 620 630 580 590 600 610 620 630 pF1KB5 NNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRP ::::.:. : ::::::::::::::::::::::::::.::::::::::.:::::::::. XP_011 NNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQH 640 650 660 670 680 690 640 650 660 670 680 690 pF1KB5 RQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKL :::::.::. ::::::::::::::::::::::::::: :::. :.::.::::::.::::: XP_011 RQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKL 700 710 720 730 740 750 700 710 720 730 740 750 pF1KB5 EKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHA :::::::::.:::::::::::::.:::::.::::::::::::::.:::: :::::::::: XP_011 EKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHA 760 770 780 790 800 810 760 770 780 790 800 810 pF1KB5 GIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRAR :::::::::::.::::::::..::::::::::::::::::::::::::::::.::::::: XP_011 GIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRAR 820 830 840 850 860 870 820 830 840 850 pF1KB5 YHLVDKEHDSGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA ::::::::::.:::: :::::::: :::::::::::::::::::: XP_011 YHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA 880 890 900 910 >>XP_011515267 (OMIM: 606229) PREDICTED: protein argonau (873 aa) initn: 4887 init1: 4887 opt: 4916 Z-score: 5956.0 bits: 1113.1 E(85289): 0 Smith-Waterman score: 4916; 83.6% identity (94.6% similar) in 845 aa overlap (15-857:30-873) 10 20 30 40 pF1KB5 MEAGPSGAAAGAYLPPLQ-QVFQAPRRPGIGTVGKPIKLLANYFE ::.: .:. : :: .:: :. ::: ::.:: XP_011 MPLCSSVRLRWENGLTADLALALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFE 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 VDIPKIDVYHYEVDIKPDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTAL .::::::.::::.::::.:::::::::.::.:::::: :::::::::.::.::.::. : XP_011 MDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPL 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB5 PIGNERVDFEVTIPGEGKDRIFKVSIKWLAIVSWRMLHEALVSGQIP-VPLESVQALDVA ::: ..:..:::.:::::::::::::::.. :: . ::.:: ::..: ::.:..:::::. XP_011 PIGRDKVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDAL-SGRLPSVPFETIQALDVV 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 MRHLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFY :::: ::::::::::::. :: .::::::::::::::::::..::::::::::::::: XP_011 MRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFY 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB5 KAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVT ::::::::.:::::...:.:: :::::::::.:::::::::::.:::::::::::::::: XP_011 KAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVT 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB5 RRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCN :::::::::::: :::::::::::::::....: :.:::::::::::::::::::::::: XP_011 RRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCN 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB5 IVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDM ::::::::::::::::::::.::::::::::::::.::..::.: :::..:::: :::.: XP_011 IVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEM 360 370 380 390 400 410 410 420 430 440 450 460 pF1KB5 TEVTGRVLPAPILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREE :.:::::: : . :::::.::::: :::::::.:::..:::::::::::::::.:: : XP_011 TDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEV 420 430 440 450 460 470 470 480 490 500 510 520 pF1KB5 VLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGK ::.::.::::::.:::::::::::::::::::::::::::::::::.::::..:::::: XP_011 HLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGK 480 490 500 510 520 530 530 540 550 560 570 580 pF1KB5 TPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSA :::::::::::::.:::::::::.::: .:.:::::::::::::::::.::::.:. : XP_011 TPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPP 540 550 560 570 580 590 590 600 610 620 630 640 pF1KB5 VFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYM ::::::::::::::::::::::::::.::::::::::.:::::::::. :::::.::. : XP_011 VFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAM 600 610 620 630 640 650 650 660 670 680 690 700 pF1KB5 VRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYI :::::::::::::::::::::::::: :::. :.::.::::::.::::::::::::::.: XP_011 VRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFI 660 670 680 690 700 710 710 720 730 740 750 760 pF1KB5 VVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHY ::::::::::::.:::::.::::::::::::::.:::: ::::::::::::::::::::: XP_011 VVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHY 720 730 740 750 760 770 770 780 790 800 810 820 pF1KB5 YVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSG .::::::::..::::::::::::::::::::::::::::::.:::::::::::::::::. XP_011 HVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSA 780 790 800 810 820 830 830 840 850 pF1KB5 EGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA :::: :::::::: :::::::::::::::::::: XP_011 EGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA 840 850 860 870 >>XP_011515268 (OMIM: 606229) PREDICTED: protein argonau (813 aa) initn: 4790 init1: 4790 opt: 4803 Z-score: 5819.4 bits: 1087.8 E(85289): 0 Smith-Waterman score: 4803; 84.6% identity (95.3% similar) in 814 aa overlap (45-857:1-813) 20 30 40 50 60 70 pF1KB5 PPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVNREVVE .::::::.::::.::::.:::::::::.:: XP_011 MDIPKIDIYHYELDIKPEKCPRRVNREIVE 10 20 30 80 90 100 110 120 130 pF1KB5 YMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDRIFKVSIKWLA .:::::: :::::::::.::.::.::. :::: ..:..:::.:::::::::::::::.. XP_011 HMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWVS 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB5 IVSWRMLHEALVSGQIP-VPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGG :: . ::.:: ::..: ::.:..:::::.:::: ::::::::::::. :: .::::: XP_011 CVSLQALHDAL-SGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGG 100 110 120 130 140 200 210 220 230 240 250 pF1KB5 REVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQR :::::::::::::..:::::::::::::::::::::::.:::::...:.:: :::::::: XP_011 REVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQR 150 160 170 180 190 200 260 270 280 290 300 310 pF1KB5 VRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQK :.:::::::::::.:::::::::::::::::::::::::::: :::::::::::::::.. XP_011 VKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDR 210 220 230 240 250 260 320 330 340 350 360 370 pF1KB5 YNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDR ..: :.::::::::::::::::::::::::::::::::::::::::::::.::::::::: XP_011 HKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDR 270 280 290 300 310 320 380 390 400 410 420 430 pF1KB5 QEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVW :::::.::..::.: :::..:::: :::.::.:::::: : . :::::.::::: :::: XP_011 QEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVW 330 340 350 360 370 380 440 450 460 470 480 490 pF1KB5 DMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYA :::.:::..:::::::::::::::.:: : ::.::.::::::.:::::::::::::::: XP_011 DMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYA 390 400 410 420 430 440 500 510 520 530 540 550 pF1KB5 QGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKT :::::::::::::::::.::::..:::::::::::::::::::.:::::::::.::: .: XP_011 QGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRT 450 460 470 480 490 500 560 570 580 590 600 610 pF1KB5 SPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVV .:::::::::::::::::.::::.:. : ::::::::::::::::::::::::::.::: XP_011 TPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVV 510 520 530 540 550 560 620 630 640 650 660 670 pF1KB5 GSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQ :::::::.:::::::::. :::::.::. ::::::::::::::::::::::::::: ::: XP_011 GSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQ 570 580 590 600 610 620 680 690 700 710 720 730 pF1KB5 LPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTT . :.::.::::::.::::::::::::::.:::::::::::::.:::::.::::::::::: XP_011 FQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTT 630 640 650 660 670 680 740 750 760 770 780 790 pF1KB5 VDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTR :::.:::: :::::::::::::::::::::.::::::::..::::::::::::::::::: XP_011 VDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTR 690 700 710 720 730 740 800 810 820 830 840 850 pF1KB5 SVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQALAKAVQVHQDTLRT :::::::::::.:::::::::::::::::.:::: :::::::: :::::::::::::::: XP_011 SVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRT 750 760 770 780 790 800 pF1KB5 MYFA :::: XP_011 MYFA 810 857 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 15:55:00 2016 done: Thu Nov 3 15:55:01 2016 Total Scan time: 11.010 Total Display time: 0.300 Function used was FASTA [36.3.4 Apr, 2011]