Result of FASTA (omim) for
pF1KB5121
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5121, 474 aa
1>>>pF1KB5121 474 - 474 aa - 474 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5937+/-0.000473; mu= 15.7709+/- 0.029
mean_var=66.4617+/-13.260, 0's: 0 Z-trim(107.9): 153 B-trim: 216 in 1/52
Lambda= 0.157322
statistics sampled from 15817 (15971) to 15817 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.537), E-opt: 0.2 (0.187), width: 16
Scan time: 8.510
The best scores are: opt bits E(85289)
NP_000803 (OMIM: 137190,617153) gamma-aminobutyric ( 474) 3135 721.2 1.5e-207
NP_000804 (OMIM: 600232) gamma-aminobutyric acid r ( 474) 2518 581.1 2.2e-165
NP_000805 (OMIM: 137192,612269,617113) gamma-amino ( 473) 2461 568.2 1.7e-161
NP_068712 (OMIM: 137192,612269,617113) gamma-amino ( 473) 2373 548.2 1.8e-155
XP_011519730 (OMIM: 137192,612269,617113) PREDICTE ( 414) 2061 477.4 3.3e-134
NP_001178250 (OMIM: 137192,612269,617113) gamma-am ( 402) 2060 477.1 3.8e-134
NP_068711 (OMIM: 600232) gamma-aminobutyric acid r ( 512) 2046 474.0 4.2e-133
NP_001265560 (OMIM: 137192,612269,617113) gamma-am ( 388) 2029 470.1 4.8e-132
NP_001178249 (OMIM: 137192,612269,617113) gamma-am ( 388) 2029 470.1 4.8e-132
XP_016863474 (OMIM: 137190,617153) PREDICTED: gamm ( 257) 1661 386.5 4.6e-107
NP_061028 (OMIM: 300349) gamma-aminobutyric acid r ( 632) 1225 287.7 6.3e-77
XP_011529486 (OMIM: 300349) PREDICTED: gamma-amino ( 406) 1219 286.3 1.1e-76
NP_000806 (OMIM: 137163,613060) gamma-aminobutyric ( 452) 1088 256.6 1.1e-67
XP_011539496 (OMIM: 137163,613060) PREDICTED: gamm ( 465) 1088 256.6 1.1e-67
XP_016856425 (OMIM: 137163,613060) PREDICTED: gamm ( 687) 1088 256.6 1.5e-67
XP_016863475 (OMIM: 137190,617153) PREDICTED: gamm ( 247) 1046 246.9 4.7e-65
NP_001243632 (OMIM: 137161) gamma-aminobutyric aci ( 462) 1024 242.0 2.6e-63
NP_002033 (OMIM: 137161) gamma-aminobutyric acid r ( 479) 1024 242.0 2.7e-63
NP_055026 (OMIM: 602729) gamma-aminobutyric acid r ( 440) 1023 241.8 2.9e-63
XP_016866178 (OMIM: 137161) PREDICTED: gamma-amino ( 392) 1014 239.7 1.1e-62
NP_001254511 (OMIM: 137161) gamma-aminobutyric aci ( 392) 1014 239.7 1.1e-62
NP_001243633 (OMIM: 137161) gamma-aminobutyric aci ( 392) 1014 239.7 1.1e-62
NP_002034 (OMIM: 137162) gamma-aminobutyric acid r ( 465) 999 236.4 1.3e-61
XP_006724550 (OMIM: 305990) PREDICTED: glycine rec ( 436) 967 229.1 1.9e-59
XP_011543797 (OMIM: 305990) PREDICTED: glycine rec ( 436) 967 229.1 1.9e-59
XP_011543798 (OMIM: 305990) PREDICTED: glycine rec ( 436) 967 229.1 1.9e-59
NP_002054 (OMIM: 305990) glycine receptor subunit ( 452) 963 228.2 3.7e-59
NP_001112357 (OMIM: 305990) glycine receptor subun ( 452) 963 228.2 3.7e-59
NP_001112358 (OMIM: 305990) glycine receptor subun ( 452) 961 227.7 5.1e-59
XP_016884916 (OMIM: 305990) PREDICTED: glycine rec ( 452) 961 227.7 5.1e-59
NP_001159532 (OMIM: 138492,614619) glycine recepto ( 497) 957 226.8 1e-58
NP_000815 (OMIM: 138492,614619) glycine receptor s ( 497) 957 226.8 1e-58
XP_011534015 (OMIM: 137162) PREDICTED: gamma-amino ( 421) 956 226.6 1.1e-58
NP_000162 (OMIM: 138491,149400) glycine receptor s ( 449) 935 221.8 3e-57
NP_001139512 (OMIM: 138491,149400) glycine recepto ( 457) 935 221.8 3.1e-57
XP_016864838 (OMIM: 138491,149400) PREDICTED: glyc ( 465) 935 221.8 3.1e-57
NP_000807 (OMIM: 137164,607681,611277) gamma-amino ( 467) 930 220.7 6.9e-57
NP_001036008 (OMIM: 600421) glycine receptor subun ( 449) 929 220.5 7.8e-57
NP_006520 (OMIM: 600421) glycine receptor subunit ( 464) 928 220.2 9.4e-57
NP_944494 (OMIM: 137164,607681,611277) gamma-amino ( 475) 925 219.6 1.5e-56
XP_016864119 (OMIM: 600421) PREDICTED: glycine rec ( 424) 924 219.3 1.6e-56
XP_016863472 (OMIM: 103780,137140) PREDICTED: gamm ( 451) 894 212.5 1.9e-54
NP_000798 (OMIM: 103780,137140) gamma-aminobutyric ( 451) 894 212.5 1.9e-54
XP_016863471 (OMIM: 103780,137140) PREDICTED: gamm ( 451) 894 212.5 1.9e-54
NP_001107647 (OMIM: 103780,137140) gamma-aminobuty ( 451) 894 212.5 1.9e-54
XP_005265929 (OMIM: 602729) PREDICTED: gamma-amino ( 361) 892 212.0 2.2e-54
XP_011511977 (OMIM: 103780,137140) PREDICTED: gamm ( 511) 893 212.3 2.5e-54
NP_001317619 (OMIM: 103780,137140) gamma-aminobuty ( 511) 893 212.3 2.5e-54
NP_775807 (OMIM: 137166) gamma-aminobutyric acid r ( 465) 884 210.3 9.5e-54
XP_006720522 (OMIM: 137142) PREDICTED: gamma-amino ( 462) 865 205.9 1.9e-52
>>NP_000803 (OMIM: 137190,617153) gamma-aminobutyric aci (474 aa)
initn: 3135 init1: 3135 opt: 3135 Z-score: 3846.9 bits: 721.2 E(85289): 1.5e-207
Smith-Waterman score: 3135; 100.0% identity (100.0% similar) in 474 aa overlap (1-474:1-474)
10 20 30 40 50 60
pF1KB5 MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 VDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDR
370 380 390 400 410 420
430 440 450 460 470
pF1KB5 HGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 HGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
430 440 450 460 470
>>NP_000804 (OMIM: 600232) gamma-aminobutyric acid recep (474 aa)
initn: 2446 init1: 2152 opt: 2518 Z-score: 3090.1 bits: 581.1 E(85289): 2.2e-165
Smith-Waterman score: 2518; 78.8% identity (92.2% similar) in 477 aa overlap (1-474:1-474)
10 20 30 40 50 60
pF1KB5 MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP
:: :..: .:. :::..:. :: :.:.:.::::: ::::::::::::::::::::::::
NP_000 MWRVRKRGYFGIWSFPLIIAAVC-AQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPP
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD
: ::: ::.:::::::::::::::::::::.:.::::::. :::::::::::::::::::
NP_000 VAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPD
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB5 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB5 SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK
::::::::::::: : ..:::::.:::::::::::::...::: :.::.::::::::.::
NP_000 SYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLK
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB5 RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI
:::::::::::::: ::::::::::::::::::::::::::::::::::.::::::::::
NP_000 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI
240 250 260 270 280 290
310 320 330 340 350
pF1KB5 PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQ--KKGASKQDQSANEKNKLEMNK
:::::::.::::::::::.::::::.:::::::.::: ::.: : .. ::: .:..::
NP_000 PYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNK
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB5 VQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGR-A
.: : :::::::::.:: . ::.. ...::..:: .::..:::::: :...:: :
NP_000 --MDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNA
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB5 LDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
:.:: . .:.:.::::::::. ::::::::.::.:::.:::..::.::.:::::::.
NP_000 LERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN
420 430 440 450 460 470
>>NP_000805 (OMIM: 137192,612269,617113) gamma-aminobuty (473 aa)
initn: 2454 init1: 2090 opt: 2461 Z-score: 3020.2 bits: 568.2 E(85289): 1.7e-161
Smith-Waterman score: 2461; 76.9% identity (91.2% similar) in 477 aa overlap (1-474:1-473)
10 20 30 40 50 60
pF1KB5 MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP
:: . . . .:..: ::....::::.:.:.:.:::.::::::.:::::::::::::::::
NP_000 MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD
: ::: ::.::::::::::::::::::::: :.::::.::::::::::::::::::::::
NP_000 VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK
::::::::::::: ::. :::::..:::::::::....::..: :.::::::::::::::
NP_000 SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI
:::::::::::::: ::::::::::::::::::::::::::::::::::.::::::::::
NP_000 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI
250 260 270 280 290 300
310 320 330 340 350
pF1KB5 PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQ--KKGASKQDQSANEKNKLEMNK
:::::::.:::::::::::::::::::::::::.::: :: : : .. :...: : :.
NP_000 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 VQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRAL
:::::::::..::..:: .:: ...: . . :.:...::::: ::..:: :
NP_000 --VDAHGNILLTSLEVHNEM--NEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFL
370 380 390 400 410
420 430 440 450 460 470
pF1KB5 DRHGVP-SKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
...: .: ..:::.::::.:::::::::.::.:::. ::.::::::.:::::::.
NP_000 GDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN
420 430 440 450 460 470
>>NP_068712 (OMIM: 137192,612269,617113) gamma-aminobuty (473 aa)
initn: 2366 init1: 2002 opt: 2373 Z-score: 2912.3 bits: 548.2 E(85289): 1.8e-155
Smith-Waterman score: 2373; 79.2% identity (91.8% similar) in 451 aa overlap (27-474:27-473)
10 20 30 40 50 60
pF1KB5 MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP
:.:.:.:::.::::::.:::::::::::::::::
NP_068 MCSGLLELLLPIWLSWTLGTRGSEPRSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD
: ::: ::.::::::::::::::::::::: :.::::.::::::::::::::::::::::
NP_068 VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK
::::::::::::: ::. :::::..:::::::::....::..: :.::::::::::::::
NP_068 SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI
:::::::::::::: ::::::::::::::::::::::::::::::::::.::::::::::
NP_068 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI
250 260 270 280 290 300
310 320 330 340 350
pF1KB5 PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQ--KKGASKQDQSANEKNKLEMNK
:::::::.:::::::::::::::::::::::::.::: :: : : .. :...: : :.
NP_068 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 VQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRAL
:::::::::..::..:: . :: ...: . . :.:...::::: ::..:: :
NP_068 --VDAHGNILLTSLEVHNEMN--EVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFL
370 380 390 400 410
420 430 440 450 460 470
pF1KB5 DRHGVP-SKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
...: .: ..:::.::::.:::::::::.::.:::. ::.::::::.:::::::.
NP_068 GDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN
420 430 440 450 460 470
>>XP_011519730 (OMIM: 137192,612269,617113) PREDICTED: g (414 aa)
initn: 2054 init1: 1690 opt: 2061 Z-score: 2530.5 bits: 477.4 E(85289): 3.3e-134
Smith-Waterman score: 2061; 77.8% identity (90.8% similar) in 400 aa overlap (78-474:19-414)
50 60 70 80 90 100
pF1KB5 YDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLT
. :::::::::: :.::::.:::::::::
XP_011 MQIPSLCDCALLFGSCHIIAKDYTLTMYFQQYWRDKRLAYSGIPLNLT
10 20 30 40
110 120 130 140 150 160
pF1KB5 LDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRR
50 60 70 80 90 100
170 180 190 200 210 220
pF1KB5 YPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTT
:::::::::::::::::::::::::: ::. :::::..:::::::::....::..: :.:
XP_011 YPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFAT
110 120 130 140 150 160
230 240 250 260 270 280
pF1KB5 GAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMT
::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::
XP_011 GAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMT
170 180 190 200 210 220
290 300 310 320 330 340
pF1KB5 TISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQ--KKGASKQD
::.:::::::::::::::::.:::::::::::::::::::::::::.::: :: : :
XP_011 TINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTA
230 240 250 260 270 280
350 360 370 380 390 400
pF1KB5 QSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYR
.. :...: : :.: ::::::::..::..:: .:: ...: . . :.:...::::
XP_011 KAKNDRSKSESNRV--DAHGNILLTSLEVHNEM--NEVSGGIGDTRNSAISFDNSGIQYR
290 300 310 320 330 340
410 420 430 440 450 460
pF1KB5 KPLSSREAYGRALDRHGVP-SKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLF
: ::..:: : ...: .: ..:::.::::.:::::::::.::.:::. ::.:::::
XP_011 KQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLF
350 360 370 380 390 400
470
pF1KB5 NVVYWLYYVH
:.:::::::.
XP_011 NLVYWLYYVN
410
>>NP_001178250 (OMIM: 137192,612269,617113) gamma-aminob (402 aa)
initn: 2053 init1: 1689 opt: 2060 Z-score: 2529.4 bits: 477.1 E(85289): 3.8e-134
Smith-Waterman score: 2060; 78.3% identity (91.2% similar) in 397 aa overlap (81-474:10-402)
60 70 80 90 100 110
pF1KB5 RLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDN
:::::::::: :.::::.::::::::::::
NP_001 MWATYQTEEDYTLTMYFQQYWRDKRLAYSGIPLNLTLDN
10 20 30
120 130 140 150 160 170
pF1KB5 RVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPL
40 50 60 70 80 90
180 190 200 210 220 230
pF1KB5 DEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAY
::::::::::::::::::::::: ::. :::::..:::::::::....::..: :.::::
NP_001 DEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAY
100 110 120 130 140 150
240 250 260 270 280 290
pF1KB5 PRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTIS
:::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::.
NP_001 PRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTIN
160 170 180 190 200 210
300 310 320 330 340
pF1KB5 THLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQ--KKGASKQDQSA
:::::::::::::::::.:::::::::::::::::::::::::.::: :: : : ..
NP_001 THLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAK
220 230 240 250 260 270
350 360 370 380 390 400
pF1KB5 NEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPL
:...: : :.: ::::::::..::..:: . :: ...: . . :.:...:::::
NP_001 NDRSKSESNRV--DAHGNILLTSLEVHNEMN--EVSGGIGDTRNSAISFDNSGIQYRKQS
280 290 300 310 320 330
410 420 430 440 450 460
pF1KB5 SSREAYGRALDRHGVP-SKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVV
::..:: : ...: .: ..:::.::::.:::::::::.::.:::. ::.::::::.:
NP_001 MPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLV
340 350 360 370 380 390
470
pF1KB5 YWLYYVH
::::::.
NP_001 YWLYYVN
400
>>NP_068711 (OMIM: 600232) gamma-aminobutyric acid recep (512 aa)
initn: 2567 init1: 1949 opt: 2046 Z-score: 2510.6 bits: 474.0 E(85289): 4.2e-133
Smith-Waterman score: 2403; 73.1% identity (85.8% similar) in 506 aa overlap (1-467:1-505)
10 20 30 40 50 60
pF1KB5 MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP
:: :..: .:. :::..:. :: :.:.:.::::: ::::::::::::::::::::::::
NP_068 MWRVRKRGYFGIWSFPLIIAAVC-AQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPP
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD
: ::: ::.:::::::::::::::::::::.:.::::::. :::::::::::::::::::
NP_068 VAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPD
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB5 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB5 SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK
::::::::::::: : ..:::::.:::::::::::::...::: :.::.::::::::.::
NP_068 SYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLK
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB5 RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI
:::::::::::::: ::::::::::::::::::::::::::::::::::.::::::::::
NP_068 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI
240 250 260 270 280 290
310 320 330 340 350
pF1KB5 PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQ--KKGASKQDQSANEKNKLEMNK
:::::::.::::::::::.::::::.:::::::.::: ::.: : .. ::: .:..::
NP_068 PYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNK
300 310 320 330 340 350
360 370 380
pF1KB5 V------------------------------------QVDAHGNILLSTLEIRNETSGSE
. .: : :::::::::.:: . ::
NP_068 IFYKDIKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSE
360 370 380 390 400 410
390 400 410 420 430 440
pF1KB5 VLTSVSDPKATMYSYDSASIQYRKPLSSREAYGR-ALDRHGVPSKGRIRRRASQLKVKIP
.. ...::..:: .::..:::::: :...:: ::.:: . .:.:.::::::::. ::
NP_068 AVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIP
420 430 440 450 460 470
450 460 470
pF1KB5 DLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
::::::.::.:::.:::..::.::.:
NP_068 DLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN
480 490 500 510
>>NP_001265560 (OMIM: 137192,612269,617113) gamma-aminob (388 aa)
initn: 2022 init1: 1658 opt: 2029 Z-score: 2491.7 bits: 470.1 E(85289): 4.8e-132
Smith-Waterman score: 2029; 78.1% identity (91.1% similar) in 392 aa overlap (86-474:1-388)
60 70 80 90 100 110
pF1KB5 FGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQ
::::: :.::::.:::::::::::::::::
NP_001 MYFQQYWRDKRLAYSGIPLNLTLDNRVADQ
10 20 30
120 130 140 150 160 170
pF1KB5 LWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNC
40 50 60 70 80 90
180 190 200 210 220 230
pF1KB5 TLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSL
:::::::::::::::::: ::. :::::..:::::::::....::..: :.:::::::::
NP_001 TLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSL
100 110 120 130 140 150
240 250 260 270 280 290
pF1KB5 SFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRE
::::::::::::::::::: ::::::::::::::::::::::::::::::::::.:::::
NP_001 SFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRE
160 170 180 190 200 210
300 310 320 330 340 350
pF1KB5 TLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQ--KKGASKQDQSANEKNK
::::::::::::.:::::::::::::::::::::::::.::: :: : : .. :...:
NP_001 TLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSK
220 230 240 250 260 270
360 370 380 390 400 410
pF1KB5 LEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREA
: :. :::::::::..::..:: . :: ...: . . :.:...::::: ::.
NP_001 SESNR--VDAHGNILLTSLEVHNEMN--EVSGGIGDTRNSAISFDNSGIQYRKQSMPREG
280 290 300 310 320
420 430 440 450 460 470
pF1KB5 YGRALDRHGVP-SKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYY
.:: : ...: .: ..:::.::::.:::::::::.::.:::. ::.::::::.::::::
NP_001 HGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYY
330 340 350 360 370 380
pF1KB5 VH
:.
NP_001 VN
>>NP_001178249 (OMIM: 137192,612269,617113) gamma-aminob (388 aa)
initn: 2022 init1: 1658 opt: 2029 Z-score: 2491.7 bits: 470.1 E(85289): 4.8e-132
Smith-Waterman score: 2029; 78.1% identity (91.1% similar) in 392 aa overlap (86-474:1-388)
60 70 80 90 100 110
pF1KB5 FGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQ
::::: :.::::.:::::::::::::::::
NP_001 MYFQQYWRDKRLAYSGIPLNLTLDNRVADQ
10 20 30
120 130 140 150 160 170
pF1KB5 LWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNC
40 50 60 70 80 90
180 190 200 210 220 230
pF1KB5 TLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSL
:::::::::::::::::: ::. :::::..:::::::::....::..: :.:::::::::
NP_001 TLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSL
100 110 120 130 140 150
240 250 260 270 280 290
pF1KB5 SFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRE
::::::::::::::::::: ::::::::::::::::::::::::::::::::::.:::::
NP_001 SFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRE
160 170 180 190 200 210
300 310 320 330 340 350
pF1KB5 TLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQ--KKGASKQDQSANEKNK
::::::::::::.:::::::::::::::::::::::::.::: :: : : .. :...:
NP_001 TLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSK
220 230 240 250 260 270
360 370 380 390 400 410
pF1KB5 LEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREA
: :. :::::::::..::..:: . :: ...: . . :.:...::::: ::.
NP_001 SESNR--VDAHGNILLTSLEVHNEMN--EVSGGIGDTRNSAISFDNSGIQYRKQSMPREG
280 290 300 310 320
420 430 440 450 460 470
pF1KB5 YGRALDRHGVP-SKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYY
.:: : ...: .: ..:::.::::.:::::::::.::.:::. ::.::::::.::::::
NP_001 HGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYY
330 340 350 360 370 380
pF1KB5 VH
:.
NP_001 VN
>>XP_016863474 (OMIM: 137190,617153) PREDICTED: gamma-am (257 aa)
initn: 1661 init1: 1661 opt: 1661 Z-score: 2043.1 bits: 386.5 E(85289): 4.6e-107
Smith-Waterman score: 1661; 100.0% identity (100.0% similar) in 257 aa overlap (218-474:1-257)
190 200 210 220 230 240
pF1KB5 DIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFI
::::::::::::::::::::::::::::::
XP_016 MVSKKVEFTTGAYPRLSLSFRLKRNIGYFI
10 20 30
250 260 270 280 290 300
pF1KB5 LQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAID
40 50 60 70 80 90
310 320 330 340 350 360
pF1KB5 IYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNI
100 110 120 130 140 150
370 380 390 400 410 420
pF1KB5 LLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKG
160 170 180 190 200 210
430 440 450 460 470
pF1KB5 RIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
220 230 240 250
474 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 22:19:34 2016 done: Thu Nov 3 22:19:35 2016
Total Scan time: 8.510 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]