FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5140, 393 aa 1>>>pF1KB5140 393 - 393 aa - 393 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1363+/-0.00036; mu= 17.0789+/- 0.022 mean_var=63.8292+/-12.880, 0's: 0 Z-trim(113.8): 69 B-trim: 102 in 1/50 Lambda= 0.160533 statistics sampled from 23192 (23271) to 23192 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.646), E-opt: 0.2 (0.273), width: 16 Scan time: 8.660 The best scores are: opt bits E(85289) NP_004974 (OMIM: 600932) G protein-activated inwar ( 393) 2626 617.1 2.3e-176 XP_016856736 (OMIM: 600932) PREDICTED: G protein-a ( 450) 2626 617.1 2.6e-176 NP_002231 (OMIM: 600877,614098) G protein-activate ( 423) 1845 436.2 6.9e-122 XP_011541111 (OMIM: 600734,613485,613677) PREDICTE ( 419) 1724 408.2 1.9e-113 NP_000881 (OMIM: 600734,613485,613677) G protein-a ( 419) 1724 408.2 1.9e-113 XP_011541112 (OMIM: 600734,613485,613677) PREDICTE ( 419) 1724 408.2 1.9e-113 NP_002230 (OMIM: 601534) G protein-activated inwar ( 501) 1478 351.2 3.1e-96 XP_011522133 (OMIM: 602323) PREDICTED: ATP-sensiti ( 433) 1323 315.3 1.7e-85 NP_066292 (OMIM: 602323) ATP-sensitive inward rect ( 433) 1323 315.3 1.7e-85 XP_005256682 (OMIM: 602323) PREDICTED: ATP-sensiti ( 433) 1323 315.3 1.7e-85 NP_001181887 (OMIM: 613236,613239) inward rectifie ( 433) 1306 311.4 2.7e-84 XP_005276976 (OMIM: 613236,613239) PREDICTED: inwa ( 535) 1306 311.4 3.2e-84 NP_000882 (OMIM: 170390,600681,609622,613980) inwa ( 427) 1283 306.0 1.1e-82 NP_001247438 (OMIM: 601534) G protein-activated in ( 308) 1210 289.1 1e-77 NP_037480 (OMIM: 603953) ATP-sensitive inward rect ( 436) 1201 287.1 5.6e-77 NP_000516 (OMIM: 125853,600937,601820,606176,61058 ( 390) 1197 286.1 9.8e-77 XP_005253415 (OMIM: 600935) PREDICTED: ATP-sensiti ( 424) 1142 273.4 7.2e-73 NP_004973 (OMIM: 600935) ATP-sensitive inward rect ( 424) 1142 273.4 7.2e-73 XP_016874772 (OMIM: 600935) PREDICTED: ATP-sensiti ( 424) 1142 273.4 7.2e-73 XP_016874773 (OMIM: 600935) PREDICTED: ATP-sensiti ( 424) 1142 273.4 7.2e-73 NP_722451 (OMIM: 241200,600359) ATP-sensitive inwa ( 372) 1037 249.0 1.3e-65 NP_722448 (OMIM: 241200,600359) ATP-sensitive inwa ( 372) 1037 249.0 1.3e-65 NP_722450 (OMIM: 241200,600359) ATP-sensitive inwa ( 372) 1037 249.0 1.3e-65 NP_722449 (OMIM: 241200,600359) ATP-sensitive inwa ( 389) 1037 249.0 1.4e-65 NP_000211 (OMIM: 241200,600359) ATP-sensitive inwa ( 391) 1037 249.0 1.4e-65 NP_004972 (OMIM: 600504) inward rectifier potassiu ( 445) 1024 246.1 1.3e-64 NP_690607 (OMIM: 600504) inward rectifier potassiu ( 445) 1024 246.1 1.3e-64 NP_001278554 (OMIM: 605722) inward rectifier potas ( 418) 977 235.2 2.3e-61 XP_011523083 (OMIM: 605722) PREDICTED: inward rect ( 418) 977 235.2 2.3e-61 NP_001278553 (OMIM: 605722) inward rectifier potas ( 418) 977 235.2 2.3e-61 NP_001257351 (OMIM: 605722) inward rectifier potas ( 418) 977 235.2 2.3e-61 XP_016880102 (OMIM: 605722) PREDICTED: inward rect ( 418) 977 235.2 2.3e-61 NP_001278552 (OMIM: 605722) inward rectifier potas ( 453) 977 235.2 2.4e-61 NP_061128 (OMIM: 605722) inward rectifier potassiu ( 453) 977 235.2 2.4e-61 XP_016880100 (OMIM: 605722) PREDICTED: inward rect ( 453) 977 235.2 2.4e-61 NP_733937 (OMIM: 605722) inward rectifier potassiu ( 453) 977 235.2 2.4e-61 XP_016880098 (OMIM: 605722) PREDICTED: inward rect ( 453) 977 235.2 2.4e-61 XP_006721948 (OMIM: 605722) PREDICTED: inward rect ( 453) 977 235.2 2.4e-61 XP_006721949 (OMIM: 605722) PREDICTED: inward rect ( 453) 977 235.2 2.4e-61 XP_016880101 (OMIM: 605722) PREDICTED: inward rect ( 453) 977 235.2 2.4e-61 NP_733938 (OMIM: 605722) inward rectifier potassiu ( 453) 977 235.2 2.4e-61 XP_006721950 (OMIM: 605722) PREDICTED: inward rect ( 453) 977 235.2 2.4e-61 NP_001278551 (OMIM: 605722) inward rectifier potas ( 453) 977 235.2 2.4e-61 XP_016880099 (OMIM: 605722) PREDICTED: inward rect ( 453) 977 235.2 2.4e-61 XP_005257394 (OMIM: 605722) PREDICTED: inward rect ( 453) 977 235.2 2.4e-61 XP_016873169 (OMIM: 125853,600937,601820,606176,61 ( 303) 973 234.2 3.3e-61 NP_001159762 (OMIM: 125853,600937,601820,606176,61 ( 303) 973 234.2 3.3e-61 XP_006718289 (OMIM: 125853,600937,601820,606176,61 ( 303) 973 234.2 3.3e-61 NP_002232 (OMIM: 274600,600791,602208,612780) ATP- ( 379) 921 222.2 1.7e-57 NP_001247437 (OMIM: 601534) G protein-activated in ( 235) 897 216.5 5.3e-56 >>NP_004974 (OMIM: 600932) G protein-activated inward re (393 aa) initn: 2626 init1: 2626 opt: 2626 Z-score: 3287.2 bits: 617.1 E(85289): 2.3e-176 Smith-Waterman score: 2626; 99.7% identity (100.0% similar) in 393 aa overlap (1-393:1-393) 10 20 30 40 50 60 pF1KB5 MAQENAAFSPGQEEPPRRRGRQRYVEKDGRCNVQQGNVRETYRYLTDLFTTLVDLQWRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MAQENAAFSPGQEEPPRRRGRQRYVEKDGRCNVQQGNVRETYRYLTDLFTTLVDLQWRLS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLNGFVAAFLFSIETETT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLNGFVAAFLFSIETETT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 IGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKRAATLVFSSHAVVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 IGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKRAATLVFSSHAVVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTDLSVGFDTGDDRLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTDLSVGFDTGDDRLF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 LVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGMTCQARSSYLVDEVLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGMTCQARSSYLVDEVLW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 GHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSARELAEAAARLDAHLYWSIPSRLDEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSARELAEAAARLDAHLYWSIPSRLDEK 310 320 330 340 350 360 370 380 390 pF1KB5 VEEEGVGEGAGGEAGADKEQNGCLPPPESESKV :::::.::::::::::::::::::::::::::: NP_004 VEEEGAGEGAGGEAGADKEQNGCLPPPESESKV 370 380 390 >>XP_016856736 (OMIM: 600932) PREDICTED: G protein-activ (450 aa) initn: 2626 init1: 2626 opt: 2626 Z-score: 3286.4 bits: 617.1 E(85289): 2.6e-176 Smith-Waterman score: 2626; 99.7% identity (100.0% similar) in 393 aa overlap (1-393:58-450) 10 20 30 pF1KB5 MAQENAAFSPGQEEPPRRRGRQRYVEKDGR :::::::::::::::::::::::::::::: XP_016 LGAQRRAAGGSSSGPRRTPGARSARPDAAAMAQENAAFSPGQEEPPRRRGRQRYVEKDGR 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB5 CNVQQGNVRETYRYLTDLFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CNVQQGNVRETYRYLTDLFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLE 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB5 HLEDTAWTPCVNNLNGFVAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HLEDTAWTPCVNNLNGFVAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVN 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB5 AFMVGCMFVKISQPNKRAATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AFMVGCMFVKISQPNKRAATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLI 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB5 RSRQTLEGEFIPLHQTDLSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSRQTLEGEFIPLHQTDLSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDF 270 280 290 300 310 320 280 290 300 310 320 330 pF1KB5 EIVVILEGMVEATGMTCQARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EIVVILEGMVEATGMTCQARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVPT 330 340 350 360 370 380 340 350 360 370 380 390 pF1KB5 PSCSARELAEAAARLDAHLYWSIPSRLDEKVEEEGVGEGAGGEAGADKEQNGCLPPPESE :::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::: XP_016 PSCSARELAEAAARLDAHLYWSIPSRLDEKVEEEGAGEGAGGEAGADKEQNGCLPPPESE 390 400 410 420 430 440 pF1KB5 SKV ::: XP_016 SKV 450 >>NP_002231 (OMIM: 600877,614098) G protein-activated in (423 aa) initn: 1847 init1: 1820 opt: 1845 Z-score: 2309.2 bits: 436.2 E(85289): 6.9e-122 Smith-Waterman score: 1845; 71.8% identity (89.6% similar) in 376 aa overlap (18-393:50-423) 10 20 30 40 pF1KB5 MAQENAAFSPGQEEPPRRRGRQRYVEKDGRCNVQQGNVRETYRYLTD .: ::::.:::.:::..:::::::::::: NP_002 DVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTD 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB5 LFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLNGF .:::::::.::..::.::..:..:::::: ::::::: :::..:.:: .:::::.::::: NP_002 IFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGF 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB5 VAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKR :.:::::::::::::::.:::::.:::::.:::.:..:::.::::::::::::::::.:: NP_002 VSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKR 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB5 AATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTD : :::::.:::.:.:::.:::::::::::.:::::::::::::.:.:: :::::::.::: NP_002 AETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTD 200 210 220 230 240 250 230 240 250 260 270 280 pF1KB5 LSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGMTC ..::. ::::::::::::.:::::. ::::: :. : ....::::::::::::::::: NP_002 INVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTC 260 270 280 290 300 310 290 300 310 320 330 340 pF1KB5 QARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSARELAEAAARLDA ::::::...:.:::.::: ::::::::::::: :::::.:. ::: ::.:::: :.: . NP_002 QARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSLSAKELAELASRAEL 320 330 340 350 360 370 350 360 370 380 390 pF1KB5 HLYWSIPSRLDEKVEEEGVGEGAGGEAGADKEQNGCLPPPESESKV : ::. :.:....: : : . : . :.:: . :.:::: NP_002 PLSWSVSSKLNQHAELETEEEEKNLE--EQTERNGDVANLENESKV 380 390 400 410 420 >>XP_011541111 (OMIM: 600734,613485,613677) PREDICTED: G (419 aa) initn: 1719 init1: 1719 opt: 1724 Z-score: 2157.8 bits: 408.2 E(85289): 1.9e-113 Smith-Waterman score: 1725; 70.0% identity (86.6% similar) in 367 aa overlap (18-372:47-411) 10 20 30 40 pF1KB5 MAQENAAFSPGQEEPPRRRGRQRYVEKDGRCNVQQGNVRETYRYLTD .. ::::.::.:.:::..:::.::::::.: XP_011 VTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKCNVHHGNVQETYRYLSD 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB5 LFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLNGF ::::::::.::..:: :...:..:::::: ::::::: ::::.:. : : :::.::.:: XP_011 LFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDHVGDQEWIPCVENLSGF 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB5 VAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKR :.::::::::::::::: ::::..:::::.:::.::::::.::::::::::::::::.:: XP_011 VSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKR 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB5 AATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTD : ::.::..::.:.:: .:::::::::::.:::::::::::::.:::: :::::::.::: XP_011 AETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTD 200 210 220 230 240 250 230 240 250 260 270 280 pF1KB5 LSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGMTC ..::::::::::::::::.:::::. ::::: :. :....::.::::::::::::::: XP_011 INVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFEVVVILEGMVEATGMTC 260 270 280 290 300 310 290 300 310 320 330 340 pF1KB5 QARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSARELAEAAARLDA ::::::. ::::::::: ::::: ::::::: .::.:.:. :::: :.:::: . .. XP_011 QARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTPSCCAKELAEM--KREG 320 330 340 350 360 370 350 360 370 380 390 pF1KB5 HLYWSIPSR----------LDEKVE--EEGVGEGAGGEAGADKEQNGCLPPPESESKV .: .:: :: ..: :: .: :: XP_011 RLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV 380 390 400 410 >>NP_000881 (OMIM: 600734,613485,613677) G protein-activ (419 aa) initn: 1719 init1: 1719 opt: 1724 Z-score: 2157.8 bits: 408.2 E(85289): 1.9e-113 Smith-Waterman score: 1725; 70.0% identity (86.6% similar) in 367 aa overlap (18-372:47-411) 10 20 30 40 pF1KB5 MAQENAAFSPGQEEPPRRRGRQRYVEKDGRCNVQQGNVRETYRYLTD .. ::::.::.:.:::..:::.::::::.: NP_000 VTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKCNVHHGNVQETYRYLSD 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB5 LFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLNGF ::::::::.::..:: :...:..:::::: ::::::: ::::.:. : : :::.::.:: NP_000 LFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDHVGDQEWIPCVENLSGF 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB5 VAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKR :.::::::::::::::: ::::..:::::.:::.::::::.::::::::::::::::.:: NP_000 VSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKR 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB5 AATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTD : ::.::..::.:.:: .:::::::::::.:::::::::::::.:::: :::::::.::: NP_000 AETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTD 200 210 220 230 240 250 230 240 250 260 270 280 pF1KB5 LSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGMTC ..::::::::::::::::.:::::. ::::: :. :....::.::::::::::::::: NP_000 INVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFEVVVILEGMVEATGMTC 260 270 280 290 300 310 290 300 310 320 330 340 pF1KB5 QARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSARELAEAAARLDA ::::::. ::::::::: ::::: ::::::: .::.:.:. :::: :.:::: . .. NP_000 QARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTPSCCAKELAEM--KREG 320 330 340 350 360 370 350 360 370 380 390 pF1KB5 HLYWSIPSR----------LDEKVE--EEGVGEGAGGEAGADKEQNGCLPPPESESKV .: .:: :: ..: :: .: :: NP_000 RLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV 380 390 400 410 >>XP_011541112 (OMIM: 600734,613485,613677) PREDICTED: G (419 aa) initn: 1719 init1: 1719 opt: 1724 Z-score: 2157.8 bits: 408.2 E(85289): 1.9e-113 Smith-Waterman score: 1725; 70.0% identity (86.6% similar) in 367 aa overlap (18-372:47-411) 10 20 30 40 pF1KB5 MAQENAAFSPGQEEPPRRRGRQRYVEKDGRCNVQQGNVRETYRYLTD .. ::::.::.:.:::..:::.::::::.: XP_011 VTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKCNVHHGNVQETYRYLSD 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB5 LFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLNGF ::::::::.::..:: :...:..:::::: ::::::: ::::.:. : : :::.::.:: XP_011 LFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDHVGDQEWIPCVENLSGF 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB5 VAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKR :.::::::::::::::: ::::..:::::.:::.::::::.::::::::::::::::.:: XP_011 VSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKR 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB5 AATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTD : ::.::..::.:.:: .:::::::::::.:::::::::::::.:::: :::::::.::: XP_011 AETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTD 200 210 220 230 240 250 230 240 250 260 270 280 pF1KB5 LSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGMTC ..::::::::::::::::.:::::. ::::: :. :....::.::::::::::::::: XP_011 INVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFEVVVILEGMVEATGMTC 260 270 280 290 300 310 290 300 310 320 330 340 pF1KB5 QARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSARELAEAAARLDA ::::::. ::::::::: ::::: ::::::: .::.:.:. :::: :.:::: . .. XP_011 QARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTPSCCAKELAEM--KREG 320 330 340 350 360 370 350 360 370 380 390 pF1KB5 HLYWSIPSR----------LDEKVE--EEGVGEGAGGEAGADKEQNGCLPPPESESKV .: .:: :: ..: :: .: :: XP_011 RLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV 380 390 400 410 >>NP_002230 (OMIM: 601534) G protein-activated inward re (501 aa) initn: 1509 init1: 1369 opt: 1478 Z-score: 1848.8 bits: 351.2 E(85289): 3.1e-96 Smith-Waterman score: 1478; 63.3% identity (87.7% similar) in 332 aa overlap (10-340:33-363) 10 20 30 pF1KB5 MAQENAAFSPGQEEPPRRRGRQRYVEKDGRCNVQQGNV- : :. :... :::.:.:.::::::.::. NP_002 ALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKK-RQRFVDKNGRCNVQHGNLG 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 RETYRYLTDLFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWT :: :::.:::::::::.:: .:..:.:.:...:::....::.::: ::::.. . .: NP_002 SETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYT 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB5 PCVNNLNGFVAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMF ::: :. .: .:::: ::::.:::::.: :::.:::::.:.:.:.::::.:.::..:::: NP_002 PCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMF 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB5 VKISQPNKRAATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEG .:.:::.::: ::.:: :::.:.:::.: ::::::.::.::.: :.:: ::..:::: :: NP_002 IKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEG 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB5 EFIPLHQTDLSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEG ::.:: : .:.:::.:: :.:::::::.: : ::: :::.. :.:... ..::::::::: NP_002 EFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILEG 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB5 MVEATGMTCQARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSAREL .::.::::::::.:: ::::::::: :..::.::..:::..:: ::::::: :..: NP_002 IVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQ 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB5 AEAAARLDAHLYWSIPSRLDEKVEEEGVGEGAGGEAGADKEQNGCLPPPESESKV : NP_002 EEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMSS 370 380 390 400 410 420 >>XP_011522133 (OMIM: 602323) PREDICTED: ATP-sensitive i (433 aa) initn: 1319 init1: 1201 opt: 1323 Z-score: 1655.7 bits: 315.3 E(85289): 1.7e-85 Smith-Waterman score: 1323; 55.3% identity (80.0% similar) in 360 aa overlap (17-369:39-398) 10 20 30 40 pF1KB5 MAQENAAFSPGQEEPPRRRGRQRYVEKDGRCNVQQGNVRE-TYRYL ::: :.:.:.:.:.::.. .:. : . ::: XP_011 PYSIVSSEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIEFANMDEKSQRYL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 TDLFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLN .:.::: ::..:: ::.: ::. .::.:: :.:.:: ..:::: : . :::: ... XP_011 ADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLEPAEGRGRTPCVMQVH 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB5 GFVAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPN ::.:::::::::.:::::: : .:..:: .. ... :.:.: ....::.: ...:...:. XP_011 GFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAIMAKMARPK 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB5 KRAATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQ ::: ::.:: .:::.::::.::::.:::.::.:::::: .::.::. : : :::.::: : XP_011 KRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQ 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB5 TDLSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGM :..:::: : ::.:::::..: :::: :::.. ::. :: ::::::::::::::::.: XP_011 IDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILEGMVEATAM 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB5 TCQARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVP-TPSCSARELAEAAAR : :::::::..:.:::::: :: : . :..::. ::.:.::: :: :::..:.: XP_011 TTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHFHKTYEVPSTPRCSAKDLVENKFL 310 320 330 340 350 360 350 360 370 380 390 pF1KB5 LDAHLYWSIPSRL-----DEKVEEEGVGEGAGGEAGADKEQNGCLPPPESESKV : . . ..: ::. : .: .: XP_011 LPSANSFCYENELAFLSRDEEDEADGDQDGRSRDGLSPQARHDFDRLQAGGGVLEQRPYR 370 380 390 400 410 420 >>NP_066292 (OMIM: 602323) ATP-sensitive inward rectifie (433 aa) initn: 1319 init1: 1201 opt: 1323 Z-score: 1655.7 bits: 315.3 E(85289): 1.7e-85 Smith-Waterman score: 1323; 55.3% identity (80.0% similar) in 360 aa overlap (17-369:39-398) 10 20 30 40 pF1KB5 MAQENAAFSPGQEEPPRRRGRQRYVEKDGRCNVQQGNVRE-TYRYL ::: :.:.:.:.:.::.. .:. : . ::: NP_066 PYSIVSSEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIEFANMDEKSQRYL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 TDLFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLN .:.::: ::..:: ::.: ::. .::.:: :.:.:: ..:::: : . :::: ... NP_066 ADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLEPAEGRGRTPCVMQVH 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB5 GFVAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPN ::.:::::::::.:::::: : .:..:: .. ... :.:.: ....::.: ...:...:. NP_066 GFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAIMAKMARPK 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB5 KRAATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQ ::: ::.:: .:::.::::.::::.:::.::.:::::: .::.::. : : :::.::: : NP_066 KRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQ 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB5 TDLSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGM :..:::: : ::.:::::..: :::: :::.. ::. :: ::::::::::::::::.: NP_066 IDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILEGMVEATAM 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB5 TCQARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVP-TPSCSARELAEAAAR : :::::::..:.:::::: :: : . :..::. ::.:.::: :: :::..:.: NP_066 TTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHFHKTYEVPSTPRCSAKDLVENKFL 310 320 330 340 350 360 350 360 370 380 390 pF1KB5 LDAHLYWSIPSRL-----DEKVEEEGVGEGAGGEAGADKEQNGCLPPPESESKV : . . ..: ::. : .: .: NP_066 LPSANSFCYENELAFLSRDEEDEADGDQDGRSRDGLSPQARHDFDRLQAGGGVLEQRPYR 370 380 390 400 410 420 >>XP_005256682 (OMIM: 602323) PREDICTED: ATP-sensitive i (433 aa) initn: 1319 init1: 1201 opt: 1323 Z-score: 1655.7 bits: 315.3 E(85289): 1.7e-85 Smith-Waterman score: 1323; 55.3% identity (80.0% similar) in 360 aa overlap (17-369:39-398) 10 20 30 40 pF1KB5 MAQENAAFSPGQEEPPRRRGRQRYVEKDGRCNVQQGNVRE-TYRYL ::: :.:.:.:.:.::.. .:. : . ::: XP_005 PYSIVSSEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIEFANMDEKSQRYL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 TDLFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLN .:.::: ::..:: ::.: ::. .::.:: :.:.:: ..:::: : . :::: ... XP_005 ADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLEPAEGRGRTPCVMQVH 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB5 GFVAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPN ::.:::::::::.:::::: : .:..:: .. ... :.:.: ....::.: ...:...:. XP_005 GFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAIMAKMARPK 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB5 KRAATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQ ::: ::.:: .:::.::::.::::.:::.::.:::::: .::.::. : : :::.::: : XP_005 KRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQ 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB5 TDLSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGM :..:::: : ::.:::::..: :::: :::.. ::. :: ::::::::::::::::.: XP_005 IDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILEGMVEATAM 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB5 TCQARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVP-TPSCSARELAEAAAR : :::::::..:.:::::: :: : . :..::. ::.:.::: :: :::..:.: XP_005 TTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHFHKTYEVPSTPRCSAKDLVENKFL 310 320 330 340 350 360 350 360 370 380 390 pF1KB5 LDAHLYWSIPSRL-----DEKVEEEGVGEGAGGEAGADKEQNGCLPPPESESKV : . . ..: ::. : .: .: XP_005 LPSANSFCYENELAFLSRDEEDEADGDQDGRSRDGLSPQARHDFDRLQAGGGVLEQRPYR 370 380 390 400 410 420 393 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 16:10:58 2016 done: Thu Nov 3 16:10:59 2016 Total Scan time: 8.660 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]