FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5147, 354 aa 1>>>pF1KB5147 354 - 354 aa - 354 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1251+/-0.00036; mu= 16.9363+/- 0.022 mean_var=62.6988+/-12.693, 0's: 0 Z-trim(113.2): 20 B-trim: 0 in 0/52 Lambda= 0.161974 statistics sampled from 22402 (22417) to 22402 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.644), E-opt: 0.2 (0.263), width: 16 Scan time: 8.200 The best scores are: opt bits E(85289) NP_001163 (OMIM: 107830) arginase-2, mitochondrial ( 354) 2340 555.5 6.3e-158 NP_000036 (OMIM: 207800,608313) arginase-1 isoform ( 322) 1336 320.9 2.5e-87 NP_001231367 (OMIM: 207800,608313) arginase-1 isof ( 330) 1317 316.4 5.5e-86 XP_011534103 (OMIM: 207800,608313) PREDICTED: argi ( 237) 540 134.8 1.9e-31 >>NP_001163 (OMIM: 107830) arginase-2, mitochondrial pre (354 aa) initn: 2340 init1: 2340 opt: 2340 Z-score: 2956.2 bits: 555.5 E(85289): 6.3e-158 Smith-Waterman score: 2340; 100.0% identity (100.0% similar) in 354 aa overlap (1-354:1-354) 10 20 30 40 50 60 pF1KB5 MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 SLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 FSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQ 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 LATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI 310 320 330 340 350 >>NP_000036 (OMIM: 207800,608313) arginase-1 isoform 2 [ (322 aa) initn: 1353 init1: 1110 opt: 1336 Z-score: 1688.9 bits: 320.9 E(85289): 2.5e-87 Smith-Waterman score: 1336; 60.1% identity (85.4% similar) in 316 aa overlap (25-340:7-321) 10 20 30 40 50 60 pF1KB5 MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSS ....::::::.:: : :::.::...:.:::...:. NP_000 MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKE 10 20 30 40 70 80 90 100 110 120 pF1KB5 LGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDH : .::.::: :. .:.:. .. .. :::::: :...:: :... ..: ..::::: NP_000 QECDVKDYGDLPFADIPNDSPFQ-IVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDH 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB5 SLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG :::::.:::::: ::: :.:::::.::::::::.:::::::::::::.::. :.:..:: NP_000 SLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPG 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB5 FSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIG :::. ::::. .::::::::::: ::.:::. :.:::: ..::::: ::::.:.. :.: NP_000 FSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLG 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB5 KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQ ...::::::::.:..::...::::::::::::::::.::.:::..:::::.::..::::. NP_000 RKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPS 230 240 250 260 270 280 310 320 330 340 350 pF1KB5 LATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI :. . ::. :.: :: . . :: .:::.: : : : NP_000 LGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK 290 300 310 320 >>NP_001231367 (OMIM: 207800,608313) arginase-1 isoform (330 aa) initn: 1322 init1: 1110 opt: 1317 Z-score: 1664.7 bits: 316.4 E(85289): 5.5e-86 Smith-Waterman score: 1317; 59.0% identity (83.6% similar) in 324 aa overlap (25-340:7-329) 10 20 30 40 50 60 pF1KB5 MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSS ....::::::.:: : :::.::...:.:::...:. NP_001 MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKE 10 20 30 40 70 80 90 100 110 pF1KB5 --------LGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYS : : .::.::: :. .:.:. .. .. :::::: :...:: :... ..: NP_001 QVTQNFLILECDVKDYGDLPFADIPNDSPFQ-IVKNPRSVGKASEQLAGKVAEVKKNGRI 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB5 CVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQ ..::::::::::.:::::: ::: :.:::::.::::::::.:::::::::::::.::. NP_001 SLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELK 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB5 DKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVME :.:..:::::. ::::. .::::::::::: ::.:::. :.:::: ..::::: :::: NP_001 GKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVME 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB5 RTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSAL .:.. :.:...::::::::.:..::...::::::::::::::::.::.:::..:::::.: NP_001 ETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB5 DLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARV :..::::.:. . ::. :.: :: . . :: .:::.: : : : NP_001 DIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK 290 300 310 320 330 pF1KB5 RI >>XP_011534103 (OMIM: 207800,608313) PREDICTED: arginase (237 aa) initn: 820 init1: 524 opt: 540 Z-score: 685.6 bits: 134.8 E(85289): 1.9e-31 Smith-Waterman score: 680; 39.2% identity (60.8% similar) in 316 aa overlap (25-340:7-236) 10 20 30 40 50 60 pF1KB5 MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSS ....::::::.:: : :::.::...:.:::...:. XP_011 MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKE 10 20 30 40 70 80 90 100 110 120 pF1KB5 LGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDH : .::.::: :. .:.:. .. .. :::::: :...:: :... ..: ..::::: XP_011 QECDVKDYGDLPFADIPNDSPFQ-IVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDH 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB5 SLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG : XP_011 S----------------------------------------------------------- 190 200 210 220 230 240 pF1KB5 FSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIG .:::. :.:::: ..::::: ::::.:.. :.: XP_011 --------------------------YILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLG 110 120 130 250 260 270 280 290 300 pF1KB5 KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQ ...::::::::.:..::...::::::::::::::::.::.:::..:::::.::..::::. XP_011 RKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPS 140 150 160 170 180 190 310 320 330 340 350 pF1KB5 LATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI :. . ::. :.: :: . . :: .:::.: : : : XP_011 LGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK 200 210 220 230 354 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 21:45:41 2016 done: Sat Nov 5 21:45:42 2016 Total Scan time: 8.200 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]