FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5161, 463 aa 1>>>pF1KB5161 463 - 463 aa - 463 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5544+/-0.000466; mu= 16.3241+/- 0.029 mean_var=64.0712+/-13.101, 0's: 0 Z-trim(109.6): 20 B-trim: 254 in 1/49 Lambda= 0.160230 statistics sampled from 17755 (17772) to 17755 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.563), E-opt: 0.2 (0.208), width: 16 Scan time: 9.050 The best scores are: opt bits E(85289) NP_003841 (OMIM: 603921,612073) succinate--CoA lig ( 463) 2968 695.2 9.4e-200 XP_016876295 (OMIM: 603921,612073) PREDICTED: succ ( 405) 2593 608.5 1e-173 XP_016876296 (OMIM: 603921,612073) PREDICTED: succ ( 384) 2396 563.0 5.1e-160 XP_016876298 (OMIM: 603921,612073) PREDICTED: succ ( 329) 2122 499.6 5.2e-141 XP_016876297 (OMIM: 603921,612073) PREDICTED: succ ( 344) 1709 404.2 2.9e-112 NP_003839 (OMIM: 603922) succinate--CoA ligase [GD ( 432) 1357 322.8 1.1e-87 XP_016862908 (OMIM: 603922) PREDICTED: succinyl-Co ( 433) 1290 307.3 5.2e-83 NP_001171070 (OMIM: 603922) succinate--CoA ligase ( 440) 1290 307.3 5.3e-83 XP_016862907 (OMIM: 603922) PREDICTED: succinyl-Co ( 445) 1290 307.3 5.3e-83 XP_016862906 (OMIM: 603922) PREDICTED: succinyl-Co ( 457) 1290 307.3 5.4e-83 XP_016862905 (OMIM: 603922) PREDICTED: succinyl-Co ( 458) 1290 307.3 5.4e-83 XP_016862904 (OMIM: 603922) PREDICTED: succinyl-Co ( 480) 1290 307.4 5.7e-83 XP_016862909 (OMIM: 603922) PREDICTED: succinyl-Co ( 408) 1285 306.2 1.1e-82 >>NP_003841 (OMIM: 603921,612073) succinate--CoA ligase (463 aa) initn: 2968 init1: 2968 opt: 2968 Z-score: 3707.2 bits: 695.2 E(85289): 9.4e-200 Smith-Waterman score: 2968; 99.8% identity (100.0% similar) in 463 aa overlap (1-463:1-463) 10 20 30 40 50 60 pF1KB5 MAASMFYGRLVAVATLRNHRPRTAQRAAAQVLGSSGLFNNHGLQVQQQQQRNLSLHEYMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MAASMFYGRLVAVATLRNHRPRTAQRAAAQVLGSSGLFNNHGLQVQQQQQRNLSLHEYMS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 MELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLKGGVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLKGGVK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 IVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 IVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQGP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 VLIGSSHGGVNIEDVAAETPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESAAENM ::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::: NP_003 VLIGSSHGGVNIEDVAAESPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESAAENM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 VKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQEDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQEDER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 DKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 FKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDAKALI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDAKALI 370 380 390 400 410 420 430 440 450 460 pF1KB5 ADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI ::::::::::::::::::::::::::::::::::::::::::: NP_003 ADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI 430 440 450 460 >>XP_016876295 (OMIM: 603921,612073) PREDICTED: succinyl (405 aa) initn: 2593 init1: 2593 opt: 2593 Z-score: 3239.6 bits: 608.5 E(85289): 1e-173 Smith-Waterman score: 2593; 99.8% identity (100.0% similar) in 405 aa overlap (59-463:1-405) 30 40 50 60 70 80 pF1KB5 AQVLGSSGLFNNHGLQVQQQQQRNLSLHEYMSMELLQEAGVSVPKGYVAKSPDEAYAIAK :::::::::::::::::::::::::::::: XP_016 MSMELLQEAGVSVPKGYVAKSPDEAYAIAK 10 20 30 90 100 110 120 130 140 pF1KB5 KLGSKDVVIKAQVLAGGRGKGTFESGLKGGVKIVFSPEEAKAVSSQMIGKKLFTKQTGEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLGSKDVVIKAQVLAGGRGKGTFESGLKGGVKIVFSPEEAKAVSSQMIGKKLFTKQTGEK 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB5 GRICNQVLVCERKYPRREYYFAITMERSFQGPVLIGSSHGGVNIEDVAAETPEAIIKEPI ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::: XP_016 GRICNQVLVCERKYPRREYYFAITMERSFQGPVLIGSSHGGVNIEDVAAESPEAIIKEPI 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB5 DIEEGIKKEQALQLAQKMGFPPNIVESAAENMVKLYSLFLKYDATMIEINPMVEDSDGAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DIEEGIKKEQALQLAQKMGFPPNIVESAAENMVKLYSLFLKYDATMIEINPMVEDSDGAV 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB5 LCMDAKINFDSNSAYRQKKIFDLQDWTQEDERDKDAAKANLNYIGLDGNIGCLVNGAGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCMDAKINFDSNSAYRQKKIFDLQDWTQEDERDKDAAKANLNYIGLDGNIGCLVNGAGLA 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB5 MATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKKVLAILVNIFGGIMRCDVIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKKVLAILVNIFGGIMRCDVIA 280 290 300 310 320 330 390 400 410 420 430 440 pF1KB5 QGIVMAVKDLEIKIPVVVRLQGTRVDDAKALIADSGLKILACDDLDEAARMVVKLSEIVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGIVMAVKDLEIKIPVVVRLQGTRVDDAKALIADSGLKILACDDLDEAARMVVKLSEIVT 340 350 360 370 380 390 450 460 pF1KB5 LAKQAHVDVKFQLPI ::::::::::::::: XP_016 LAKQAHVDVKFQLPI 400 >>XP_016876296 (OMIM: 603921,612073) PREDICTED: succinyl (384 aa) initn: 2396 init1: 2396 opt: 2396 Z-score: 2993.9 bits: 563.0 E(85289): 5.1e-160 Smith-Waterman score: 2396; 99.5% identity (100.0% similar) in 374 aa overlap (90-463:11-384) 60 70 80 90 100 110 pF1KB5 SMELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLKGGV .::::::::::::::::::::::::::::: XP_016 MMNSMAERSVVGSKDVVIKAQVLAGGRGKGTFESGLKGGV 10 20 30 40 120 130 140 150 160 170 pF1KB5 KIVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KIVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQG 50 60 70 80 90 100 180 190 200 210 220 230 pF1KB5 PVLIGSSHGGVNIEDVAAETPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESAAEN :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: XP_016 PVLIGSSHGGVNIEDVAAESPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESAAEN 110 120 130 140 150 160 240 250 260 270 280 290 pF1KB5 MVKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQEDE 170 180 190 200 210 220 300 310 320 330 340 350 pF1KB5 RDKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTE 230 240 250 260 270 280 360 370 380 390 400 410 pF1KB5 AFKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDAKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AFKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDAKAL 290 300 310 320 330 340 420 430 440 450 460 pF1KB5 IADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI :::::::::::::::::::::::::::::::::::::::::::: XP_016 IADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI 350 360 370 380 >>XP_016876298 (OMIM: 603921,612073) PREDICTED: succinyl (329 aa) initn: 2122 init1: 2122 opt: 2122 Z-score: 2652.6 bits: 499.6 E(85289): 5.2e-141 Smith-Waterman score: 2122; 99.7% identity (100.0% similar) in 329 aa overlap (135-463:1-329) 110 120 130 140 150 160 pF1KB5 GRGKGTFESGLKGGVKIVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPR :::::::::::::::::::::::::::::: XP_016 MIGKKLFTKQTGEKGRICNQVLVCERKYPR 10 20 30 170 180 190 200 210 220 pF1KB5 REYYFAITMERSFQGPVLIGSSHGGVNIEDVAAETPEAIIKEPIDIEEGIKKEQALQLAQ ::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::: XP_016 REYYFAITMERSFQGPVLIGSSHGGVNIEDVAAESPEAIIKEPIDIEEGIKKEQALQLAQ 40 50 60 70 80 90 230 240 250 260 270 280 pF1KB5 KMGFPPNIVESAAENMVKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KMGFPPNIVESAAENMVKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYR 100 110 120 130 140 150 290 300 310 320 330 340 pF1KB5 QKKIFDLQDWTQEDERDKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QKKIFDLQDWTQEDERDKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPAN 160 170 180 190 200 210 350 360 370 380 390 400 pF1KB5 FLDVGGGATVHQVTEAFKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLDVGGGATVHQVTEAFKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPV 220 230 240 250 260 270 410 420 430 440 450 460 pF1KB5 VVRLQGTRVDDAKALIADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVRLQGTRVDDAKALIADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI 280 290 300 310 320 >>XP_016876297 (OMIM: 603921,612073) PREDICTED: succinyl (344 aa) initn: 1709 init1: 1709 opt: 1709 Z-score: 2136.4 bits: 404.2 E(85289): 2.9e-112 Smith-Waterman score: 1709; 99.6% identity (100.0% similar) in 267 aa overlap (1-267:1-267) 10 20 30 40 50 60 pF1KB5 MAASMFYGRLVAVATLRNHRPRTAQRAAAQVLGSSGLFNNHGLQVQQQQQRNLSLHEYMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAASMFYGRLVAVATLRNHRPRTAQRAAAQVLGSSGLFNNHGLQVQQQQQRNLSLHEYMS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 MELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLKGGVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLKGGVK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 IVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQGP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 VLIGSSHGGVNIEDVAAETPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESAAENM ::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::: XP_016 VLIGSSHGGVNIEDVAAESPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESAAENM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 VKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQEDER ::::::::::::::::::::::::::: XP_016 VKLYSLFLKYDATMIEINPMVEDSDGAGPPGSHIELSCHIHLTWNRSGSLIYFLTLFFVV 250 260 270 280 290 300 >>NP_003839 (OMIM: 603922) succinate--CoA ligase [GDP-fo (432 aa) initn: 1377 init1: 1354 opt: 1357 Z-score: 1695.0 bits: 322.8 E(85289): 1.1e-87 Smith-Waterman score: 1357; 52.0% identity (78.6% similar) in 425 aa overlap (21-441:4-426) 10 20 30 40 50 pF1KB5 MAASMFYGRLVAVATLRNHRPRTAQRAAAQVLGSSGL---FNNHGLQ-VQQQQQRNLSLH : .:: :...: . .: : : : :: ..: :.:. NP_003 MASPVAAQ--AGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQ 10 20 30 40 60 70 80 90 100 110 pF1KB5 EYMSMELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLK ::.: .:... :: : . .:: . .:: ::.:..:..:.:::.::::::::.:.:::: NP_003 EYQSKKLMSDNGVRVQRFFVADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLK 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB5 GGVKIVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERS :::... .:. . ...:::: .: :::: ..: :.:.: : :: :.:: :.:: NP_003 GGVHLTKDPNVVGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRS 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB5 FQGPVLIGSSHGGVNIEDVAAETPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESA .::::.:: .:::.::.::: .:: :.:: ::: :::: :: ..:...:: . .: NP_003 CNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQA 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB5 AENMVKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQ :....:::.:::: :::..:.::. : .: :.:.:::::::.:. .::: :: ..: .. NP_003 ADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSE 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB5 EDERDKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQ .. ...::: .:.::::::::.:.:::::::::: ::: :.:: ::::::.:::. : NP_003 NEPIENEAAKYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQ 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB5 VTEAFKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDA : .::::.:.: :: ::::::::::. : .::.::. : ..::.:.:.::::.:: :..: NP_003 VYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTNVQEA 350 360 370 380 390 400 420 430 440 450 460 pF1KB5 KALIADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI . .. .::: : . ::..::. .: NP_003 QKILNNSGLPITSAIDLEDAAKKAVASVAKK 410 420 430 >>XP_016862908 (OMIM: 603922) PREDICTED: succinyl-CoA li (433 aa) initn: 1287 init1: 1287 opt: 1290 Z-score: 1611.3 bits: 307.3 E(85289): 5.2e-83 Smith-Waterman score: 1290; 53.2% identity (79.0% similar) in 395 aa overlap (21-411:4-396) 10 20 30 40 50 pF1KB5 MAASMFYGRLVAVATLRNHRPRTAQRAAAQVLGSSGL---FNNHGLQ-VQQQQQRNLSLH : .:: :...: . .: : : : :: ..: :.:. XP_016 MASPVAAQ--AGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQ 10 20 30 40 60 70 80 90 100 110 pF1KB5 EYMSMELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLK ::.: .:... :: : . .:: . .:: ::.:..:..:.:::.::::::::.:.:::: XP_016 EYQSKKLMSDNGVRVQRFFVADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLK 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB5 GGVKIVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERS :::... .:. . ...:::: .: :::: ..: :.:.: : :: :.:: :.:: XP_016 GGVHLTKDPNVVGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRS 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB5 FQGPVLIGSSHGGVNIEDVAAETPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESA .::::.:: .:::.::.::: .:: :.:: ::: :::: :: ..:...:: . .: XP_016 CNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQA 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB5 AENMVKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQ :....:::.:::: :::..:.::. : .: :.:.:::::::.:. .::: :: ..: .. XP_016 ADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSE 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB5 EDERDKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQ .. ...::: .:.::::::::.:.:::::::::: ::: :.:: ::::::.:::. : XP_016 NEPIENEAAKYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQ 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB5 VTEAFKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDA : .::::.:.: :: ::::::::::. : .::.::. : ..::.:.:.::::.:: XP_016 VYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTFMEKK 350 360 370 380 390 400 420 430 440 450 460 pF1KB5 KALIADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI XP_016 GSYMHIKQETGNSNENITGIQENVAHQNLRLN 410 420 430 >>NP_001171070 (OMIM: 603922) succinate--CoA ligase [GDP (440 aa) initn: 1287 init1: 1287 opt: 1290 Z-score: 1611.2 bits: 307.3 E(85289): 5.3e-83 Smith-Waterman score: 1290; 53.2% identity (79.0% similar) in 395 aa overlap (21-411:4-396) 10 20 30 40 50 pF1KB5 MAASMFYGRLVAVATLRNHRPRTAQRAAAQVLGSSGL---FNNHGLQ-VQQQQQRNLSLH : .:: :...: . .: : : : :: ..: :.:. NP_001 MASPVAAQ--AGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQ 10 20 30 40 60 70 80 90 100 110 pF1KB5 EYMSMELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLK ::.: .:... :: : . .:: . .:: ::.:..:..:.:::.::::::::.:.:::: NP_001 EYQSKKLMSDNGVRVQRFFVADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLK 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB5 GGVKIVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERS :::... .:. . ...:::: .: :::: ..: :.:.: : :: :.:: :.:: NP_001 GGVHLTKDPNVVGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRS 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB5 FQGPVLIGSSHGGVNIEDVAAETPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESA .::::.:: .:::.::.::: .:: :.:: ::: :::: :: ..:...:: . .: NP_001 CNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQA 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB5 AENMVKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQ :....:::.:::: :::..:.::. : .: :.:.:::::::.:. .::: :: ..: .. NP_001 ADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSE 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB5 EDERDKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQ .. ...::: .:.::::::::.:.:::::::::: ::: :.:: ::::::.:::. : NP_001 NEPIENEAAKYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQ 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB5 VTEAFKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDA : .::::.:.: :: ::::::::::. : .::.::. : ..::.:.:.::::.:: NP_001 VYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTFMEKK 350 360 370 380 390 400 420 430 440 450 460 pF1KB5 KALIADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI NP_001 GSYMHIKQETGNSNENITGIQENVAHQNLSKCAISIFLC 410 420 430 440 >>XP_016862907 (OMIM: 603922) PREDICTED: succinyl-CoA li (445 aa) initn: 1287 init1: 1287 opt: 1290 Z-score: 1611.1 bits: 307.3 E(85289): 5.3e-83 Smith-Waterman score: 1290; 53.2% identity (79.0% similar) in 395 aa overlap (21-411:4-396) 10 20 30 40 50 pF1KB5 MAASMFYGRLVAVATLRNHRPRTAQRAAAQVLGSSGL---FNNHGLQ-VQQQQQRNLSLH : .:: :...: . .: : : : :: ..: :.:. XP_016 MASPVAAQ--AGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQ 10 20 30 40 60 70 80 90 100 110 pF1KB5 EYMSMELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLK ::.: .:... :: : . .:: . .:: ::.:..:..:.:::.::::::::.:.:::: XP_016 EYQSKKLMSDNGVRVQRFFVADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLK 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB5 GGVKIVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERS :::... .:. . ...:::: .: :::: ..: :.:.: : :: :.:: :.:: XP_016 GGVHLTKDPNVVGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRS 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB5 FQGPVLIGSSHGGVNIEDVAAETPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESA .::::.:: .:::.::.::: .:: :.:: ::: :::: :: ..:...:: . .: XP_016 CNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQA 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB5 AENMVKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQ :....:::.:::: :::..:.::. : .: :.:.:::::::.:. .::: :: ..: .. XP_016 ADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSE 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB5 EDERDKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQ .. ...::: .:.::::::::.:.:::::::::: ::: :.:: ::::::.:::. : XP_016 NEPIENEAAKYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQ 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB5 VTEAFKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDA : .::::.:.: :: ::::::::::. : .::.::. : ..::.:.:.::::.:: XP_016 VYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTFMEKK 350 360 370 380 390 400 420 430 440 450 460 pF1KB5 KALIADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI XP_016 GSYMHIKQETGNSNENITGIQENVAHQNLIEKDIHIQTYGITGL 410 420 430 440 >>XP_016862906 (OMIM: 603922) PREDICTED: succinyl-CoA li (457 aa) initn: 1287 init1: 1287 opt: 1290 Z-score: 1610.9 bits: 307.3 E(85289): 5.4e-83 Smith-Waterman score: 1290; 53.2% identity (79.0% similar) in 395 aa overlap (21-411:4-396) 10 20 30 40 50 pF1KB5 MAASMFYGRLVAVATLRNHRPRTAQRAAAQVLGSSGL---FNNHGLQ-VQQQQQRNLSLH : .:: :...: . .: : : : :: ..: :.:. XP_016 MASPVAAQ--AGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQ 10 20 30 40 60 70 80 90 100 110 pF1KB5 EYMSMELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLK ::.: .:... :: : . .:: . .:: ::.:..:..:.:::.::::::::.:.:::: XP_016 EYQSKKLMSDNGVRVQRFFVADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLK 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB5 GGVKIVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERS :::... .:. . ...:::: .: :::: ..: :.:.: : :: :.:: :.:: XP_016 GGVHLTKDPNVVGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRS 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB5 FQGPVLIGSSHGGVNIEDVAAETPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESA .::::.:: .:::.::.::: .:: :.:: ::: :::: :: ..:...:: . .: XP_016 CNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQA 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB5 AENMVKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQ :....:::.:::: :::..:.::. : .: :.:.:::::::.:. .::: :: ..: .. XP_016 ADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSE 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB5 EDERDKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQ .. ...::: .:.::::::::.:.:::::::::: ::: :.:: ::::::.:::. : XP_016 NEPIENEAAKYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQ 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB5 VTEAFKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDA : .::::.:.: :: ::::::::::. : .::.::. : ..::.:.:.::::.:: XP_016 VYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTFMEKK 350 360 370 380 390 400 420 430 440 450 460 pF1KB5 KALIADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI XP_016 GSYMHIKQETGNSNENITGIQENVAHQNLTCPHHLKPQPQLHLSNRYFQTLLEDKA 410 420 430 440 450 463 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 06:22:00 2016 done: Sat Nov 5 06:22:01 2016 Total Scan time: 9.050 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]