FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5162, 217 aa 1>>>pF1KB5162 217 - 217 aa - 217 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.3586+/-0.00117; mu= 2.9162+/- 0.068 mean_var=198.8076+/-44.709, 0's: 0 Z-trim(107.6): 219 B-trim: 0 in 0/50 Lambda= 0.090962 statistics sampled from 9404 (9684) to 9404 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.681), E-opt: 0.2 (0.297), width: 16 Scan time: 2.030 The best scores are: opt bits E(32554) CCDS11721.1 GRB2 gene_id:2885|Hs108|chr17 ( 217) 1519 211.9 2.6e-55 CCDS11202.1 GRAP gene_id:10750|Hs108|chr17 ( 217) 930 134.6 4.7e-32 CCDS11722.1 GRB2 gene_id:2885|Hs108|chr17 ( 176) 836 122.1 2.1e-28 CCDS13999.1 GRAP2 gene_id:9402|Hs108|chr22 ( 330) 570 87.5 1e-17 CCDS45627.1 GRAPL gene_id:400581|Hs108|chr17 ( 118) 460 72.6 1.2e-13 CCDS82085.1 GRAP gene_id:10750|Hs108|chr17 ( 205) 460 72.9 1.7e-13 >>CCDS11721.1 GRB2 gene_id:2885|Hs108|chr17 (217 aa) initn: 1519 init1: 1519 opt: 1519 Z-score: 1106.6 bits: 211.9 E(32554): 2.6e-55 Smith-Waterman score: 1519; 100.0% identity (100.0% similar) in 217 aa overlap (1-217:1-217) 10 20 30 40 50 60 pF1KB5 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG 130 140 150 160 170 180 190 200 210 pF1KB5 DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV ::::::::::::::::::::::::::::::::::::: CCDS11 DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV 190 200 210 >>CCDS11202.1 GRAP gene_id:10750|Hs108|chr17 (217 aa) initn: 934 init1: 724 opt: 930 Z-score: 688.9 bits: 134.6 E(32554): 4.7e-32 Smith-Waterman score: 930; 59.7% identity (85.6% similar) in 216 aa overlap (1-214:1-216) 10 20 30 40 50 60 pF1KB5 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW ::..: :.:.:: .:::.:..:: ::.:: : ::::::::: : .::::::::..::::: CCDS11 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL . :.: : :::.: :. : ::::::::::.::.::.::..:..::::::::...::::: CCDS11 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQP--TYVQALFDFDPQEDGELGFR : ::::::::::..:.:......:::::: : . ..: ..:: :::. :. ..:.:: CCDS11 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR 130 140 150 160 170 180 180 190 200 210 pF1KB5 RGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV :::.:.:.. ::.::.: :..:.:::.:: ::. CCDS11 RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL 190 200 210 >>CCDS11722.1 GRB2 gene_id:2885|Hs108|chr17 (176 aa) initn: 836 init1: 836 opt: 836 Z-score: 623.3 bits: 122.1 E(32554): 2.1e-28 Smith-Waterman score: 1152; 81.1% identity (81.1% similar) in 217 aa overlap (1-217:1-176) 10 20 30 40 50 60 pF1KB5 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHP- 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL :::::::::::::::::::: CCDS11 ----------------------------------------FGNDVQHFKVLRDGAGKYFL 60 70 130 140 150 160 170 180 pF1KB5 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG 80 90 100 110 120 130 190 200 210 pF1KB5 DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV ::::::::::::::::::::::::::::::::::::: CCDS11 DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV 140 150 160 170 >>CCDS13999.1 GRAP2 gene_id:9402|Hs108|chr22 (330 aa) initn: 784 init1: 328 opt: 570 Z-score: 431.4 bits: 87.5 E(32554): 1e-17 Smith-Waterman score: 570; 53.3% identity (84.7% similar) in 150 aa overlap (1-150:1-147) 10 20 30 40 50 60 pF1KB5 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW :::.::.:: :...:::::. ::.::.:... ..:.::::....:..:::.:... : CCDS13 MEAVAKFDFTASGEDELSFHTGDVLKILSNQ--EEWFKAELGSQEGYVPKNFIDIQFPKW 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL : . : .::..: .. : :.:: :.:.:::::.::. .:::::::.::. :.::: CCDS13 FHEGLSRHQAENLLMG-KEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB5 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG :. :: :::.::::.:..:.::..:::::: CCDS13 WTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEE 120 130 140 150 160 170 >>CCDS45627.1 GRAPL gene_id:400581|Hs108|chr17 (118 aa) initn: 460 init1: 460 opt: 460 Z-score: 358.7 bits: 72.6 E(32554): 1.2e-13 Smith-Waterman score: 460; 66.7% identity (85.9% similar) in 99 aa overlap (1-99:1-99) 10 20 30 40 50 60 pF1KB5 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW ::..: :.:.:: .:::.:..:: ::.:: : ::::::::: : .::::::::..::::: CCDS45 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL . :.: : :::.: :. : ::::::::::.::.::.:: CCDS45 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNNRAQRGPCLGPKSHSRLG 70 80 90 100 110 130 140 150 160 170 180 pF1KB5 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG >>CCDS82085.1 GRAP gene_id:10750|Hs108|chr17 (205 aa) initn: 460 init1: 460 opt: 460 Z-score: 355.8 bits: 72.9 E(32554): 1.7e-13 Smith-Waterman score: 460; 66.7% identity (85.9% similar) in 99 aa overlap (1-99:1-99) 10 20 30 40 50 60 pF1KB5 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW ::..: :.:.:: .:::.:..:: ::.:: : ::::::::: : .::::::::..::::: CCDS82 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL . :.: : :::.: :. : ::::::::::.::.::.:: CCDS82 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNHLGPALPRPSLTSQPRTPRS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG CCDS82 SASAVATSLRSWSAQTPTGGGAGPAGALASSHGVTCSPCTCEQPGGRSGQRAFLQELRSR 130 140 150 160 170 180 217 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 16:14:16 2016 done: Thu Nov 3 16:14:17 2016 Total Scan time: 2.030 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]