FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5164, 427 aa 1>>>pF1KB5164 427 - 427 aa - 427 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.0476+/-0.000838; mu= 5.1882+/- 0.050 mean_var=158.0293+/-31.421, 0's: 0 Z-trim(113.3): 24 B-trim: 57 in 1/52 Lambda= 0.102025 statistics sampled from 13927 (13947) to 13927 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.768), E-opt: 0.2 (0.428), width: 16 Scan time: 3.480 The best scores are: opt bits E(32554) CCDS12775.1 IRF3 gene_id:3661|Hs108|chr19 ( 427) 3028 457.3 1.3e-128 CCDS59409.1 IRF3 gene_id:3661|Hs108|chr19 ( 452) 2343 356.5 3.1e-98 CCDS59408.1 IRF3 gene_id:3661|Hs108|chr19 ( 281) 2002 306.2 2.7e-83 CCDS56099.1 IRF3 gene_id:3661|Hs108|chr19 ( 300) 1422 220.8 1.4e-57 CCDS59407.1 IRF3 gene_id:3661|Hs108|chr19 ( 154) 688 112.6 2.7e-25 CCDS10956.1 IRF8 gene_id:3394|Hs108|chr16 ( 426) 476 81.7 1.6e-15 CCDS5808.1 IRF5 gene_id:3663|Hs108|chr7 ( 498) 393 69.5 8.4e-12 CCDS43645.1 IRF5 gene_id:3663|Hs108|chr7 ( 514) 383 68.0 2.4e-11 CCDS1492.1 IRF6 gene_id:3664|Hs108|chr1 ( 467) 373 66.5 6.1e-11 >>CCDS12775.1 IRF3 gene_id:3661|Hs108|chr19 (427 aa) initn: 3028 init1: 3028 opt: 3028 Z-score: 2422.4 bits: 457.3 E(32554): 1.3e-128 Smith-Waterman score: 3028; 100.0% identity (100.0% similar) in 427 aa overlap (1-427:1-427) 10 20 30 40 50 60 pF1KB5 MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 TGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 DTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 DTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 PFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 PFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 WPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 WPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 PNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 RLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 RLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMD 370 380 390 400 410 420 pF1KB5 FQGPGES ::::::: CCDS12 FQGPGES >>CCDS59409.1 IRF3 gene_id:3661|Hs108|chr19 (452 aa) initn: 2343 init1: 2343 opt: 2343 Z-score: 1877.2 bits: 356.5 E(32554): 3.1e-98 Smith-Waterman score: 2343; 100.0% identity (100.0% similar) in 327 aa overlap (1-327:1-327) 10 20 30 40 50 60 pF1KB5 MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 TGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 DTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 DTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 PFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 PFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 WPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 WPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTK ::::::::::::::::::::::::::: CCDS59 PNSGHGPDGEVPKDKEGGVFDLGPFIVGSWAPRSDYLHGRKRTLTTLCPLVLCGGVMAPG 310 320 330 340 350 360 >>CCDS59408.1 IRF3 gene_id:3661|Hs108|chr19 (281 aa) initn: 2002 init1: 2002 opt: 2002 Z-score: 1608.9 bits: 306.2 E(32554): 2.7e-83 Smith-Waterman score: 2002; 100.0% identity (100.0% similar) in 281 aa overlap (147-427:1-281) 120 130 140 150 160 170 pF1KB5 FSQPDTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSL :::::::::::::::::::::::::::::: CCDS59 MVLAPLPDPGPPSLAVAPEPCPQPLRSPSL 10 20 30 180 190 200 210 220 230 pF1KB5 DNPTPFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 DNPTPFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDR 40 50 60 70 80 90 240 250 260 270 280 290 pF1KB5 TLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 TLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVS 100 110 120 130 140 150 300 310 320 330 340 350 pF1KB5 EELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 EELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQ 160 170 180 190 200 210 360 370 380 390 400 410 pF1KB5 PWTKRLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 PWTKRLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLV 220 230 240 250 260 270 420 pF1KB5 EGMDFQGPGES ::::::::::: CCDS59 EGMDFQGPGES 280 >>CCDS56099.1 IRF3 gene_id:3661|Hs108|chr19 (300 aa) initn: 1422 init1: 1422 opt: 1422 Z-score: 1147.1 bits: 220.8 E(32554): 1.4e-57 Smith-Waterman score: 1841; 70.3% identity (70.3% similar) in 427 aa overlap (1-427:1-300) 10 20 30 40 50 60 pF1KB5 MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 TGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 DTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 DTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 PFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPG :::::::::::::::::::: CCDS56 PFPNLGPSENPLKRLLVPGE---------------------------------------- 190 200 250 260 270 280 290 300 pF1KB5 WPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELL CCDS56 ------------------------------------------------------------ 310 320 330 340 350 360 pF1KB5 PNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTK ::::::::::::::::::::::::::::::::: CCDS56 ---------------------------DLITFTEGSGRSPRYALWFCVGESWPQDQPWTK 210 220 230 370 380 390 400 410 420 pF1KB5 RLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 RLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMD 240 250 260 270 280 290 pF1KB5 FQGPGES ::::::: CCDS56 FQGPGES 300 >>CCDS59407.1 IRF3 gene_id:3661|Hs108|chr19 (154 aa) initn: 1067 init1: 685 opt: 688 Z-score: 567.5 bits: 112.6 E(32554): 2.7e-25 Smith-Waterman score: 815; 54.8% identity (54.8% similar) in 281 aa overlap (147-427:1-154) 120 130 140 150 160 170 pF1KB5 FSQPDTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSL :::::::::::::::::::::::::::::: CCDS59 MVLAPLPDPGPPSLAVAPEPCPQPLRSPSL 10 20 30 180 190 200 210 220 230 pF1KB5 DNPTPFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDR :::::::::::::::::::::::: CCDS59 DNPTPFPNLGPSENPLKRLLVPGE------------------------------------ 40 50 240 250 260 270 280 290 pF1KB5 TLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVS CCDS59 ------------------------------------------------------------ 300 310 320 330 340 350 pF1KB5 EELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQ ::::::::::::::::::::::::::::: CCDS59 -------------------------------DLITFTEGSGRSPRYALWFCVGESWPQDQ 60 70 80 360 370 380 390 400 410 pF1KB5 PWTKRLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 PWTKRLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLV 90 100 110 120 130 140 420 pF1KB5 EGMDFQGPGES ::::::::::: CCDS59 EGMDFQGPGES 150 >>CCDS10956.1 IRF8 gene_id:3394|Hs108|chr16 (426 aa) initn: 263 init1: 196 opt: 476 Z-score: 392.4 bits: 81.7 E(32554): 1.6e-15 Smith-Waterman score: 480; 28.1% identity (54.3% similar) in 409 aa overlap (7-387:9-390) 10 20 30 40 50 pF1KB5 MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQE-DFGIFQAW :. ::. :.: .. :. : :. .. :::::::. .:: .:: : .::.:: CCDS10 MCDRNGGRRLRQWLIEQIDSSMYPGLIWENEEKSMFRIPWKHAGKQDYNQEVDASIFKAW 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 AEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSK-DPHDPHKIYEFVNS---- : : . : :: . ::: .: :::.. .. . :::. : .:.:.:..: CCDS10 AVFKGKFKEG-DKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYRIVPEEEQK 70 80 90 100 110 120 130 140 150 160 pF1KB5 ---GVGDFSQPDTSPDTNGGGSTSDT--QEDILDELLGNMVLAPLPDPGPPSLAVAPEPC ::. . . . . : : : .: .:. .: . .: : :: : CCDS10 CKLGVATAGCVNEVTEMECGRSEIDELIKEPSVDDYMGMIKRSPSP----------PEAC 120 130 140 150 160 170 180 190 200 210 pF1KB5 PQPL------RSPSLDNP--TPFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQT . : ..:: : : . . .. ...... . .: :. : : : CCDS10 RSQLLPDWWAQQPSTGVPLVTGYTTYDAHHSAFSQMVI---------SFYYGGKLVGQAT 170 180 190 200 210 220 220 230 240 250 260 270 pF1KB5 ISCPEGLRLVGSEVGDRTLPGWPVTLPD--------PGMSLTDRGVMSYVRHVLSCLGGG .:::: :: :. : ::: . :. :. .. .. . .:.... : : CCDS10 TTCPEGCRLSLSQPG---LPGTKLYGPEGLELVRFPPADAIPSERQRQVTRKLFGHLERG 230 240 250 260 270 280 290 300 310 320 330 pF1KB5 LALWRAGQWLWAQRLGHCHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLIT . : . : ....:: :. : . . .:. :. .. .:. ::: . :. .: CCDS10 VLLHSSRQGVFVKRL--CQGRVFCSGNAVVCKGR-PN-KLERDEVVQVFDTSQFFRELQQ 280 290 300 310 320 330 340 350 360 370 380 390 pF1KB5 FTEGSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMA-RVGGASSLENT : ...:: : . .: :: .:. : ..:..:.. .: :.: : . ::.:. CCDS10 FYNSQGRLPDGRVVLCFGEEFPDMAPLRSKLILVQIEQLYVRQLAEEAGKSCGAGSVMQA 340 350 360 370 380 390 400 410 420 pF1KB5 VDLHISNSHPLSLTSDQYKAYLQDLVEGMDFQGPGES CCDS10 PEEPPPDQVFRMFPDICASHQRSFFRENQQITV 400 410 420 >>CCDS5808.1 IRF5 gene_id:3663|Hs108|chr7 (498 aa) initn: 557 init1: 159 opt: 393 Z-score: 325.3 bits: 69.5 E(32554): 8.4e-12 Smith-Waterman score: 645; 32.3% identity (54.6% similar) in 458 aa overlap (3-409:10-459) 10 20 30 40 50 pF1KB5 MGTP--KPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQE-D :: . :. ::::.:.. : :. ::: . : :::.:. :. .:. : CCDS58 MNQSIPVAPTPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGD 10 20 30 40 50 60 60 70 80 90 100 pF1KB5 FGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKD-PHDPHKIYEF ::.:::. :: :. : :. : :: :.: :::... .:: : .: : .:.:::: CCDS58 NTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEV 70 80 90 100 110 120 110 120 130 140 150 pF1KB5 VNSGVGDF-SQPDTSPDTNGGGSTSDTQEDILDELLGNMVLA------PLPDPG---PPS ..: . ::: : . :.. . .:. :...: .. :. : .: ::. CCDS58 CSNGPAPTDSQPPE--DYSFGAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLRPPT 130 140 150 160 170 160 170 180 190 pF1KB5 LAVA----------PEPCPQPLRSPSLD------------NPTPFP-NLGPS-ENPLKRL : : : :.:: : . .: :.: .: :. :. : : CCDS58 LQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRELLSEVLEPGPLPASLPPAGEQLLPDL 180 190 200 210 220 230 200 210 220 230 240 pF1KB5 LVPGEEW---EFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRT----LPGWPVTL--- :. . ..:. :::: ::: :.: :: :.. : : :..: CCDS58 LISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFG-PISLEQV 240 250 260 270 280 290 250 260 270 280 290 300 pF1KB5 --PDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELLPNS :.: .:. . :. ..:. : :: : :: :.: :: .:...:. .: CCDS58 RFPSPEDIPSDKQRF-YTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDS 300 310 320 330 340 350 310 320 330 340 350 360 pF1KB5 GHGPDGEVPKDKEGGVFDLGPFIVDLITFTEG-SGRSPRYALWFCVGESWPQDQPWTKRL .: . .. . .:.: :. .:: : .: .. : . ..:: :: ::. .: :.: CCDS58 CPNP---IQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKPREKKL 360 370 380 390 400 410 370 380 390 400 410 420 pF1KB5 VMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMDFQ . :.:::. : :.:: : : ... :.::: . .:.: CCDS58 ITVQVVPVAARLLLEMFS-GELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQ 420 430 440 450 460 470 pF1KB5 GPGES CCDS58 PVAQAPPGAGLGVGQGPWPMHPAGMQ 480 490 >>CCDS43645.1 IRF5 gene_id:3663|Hs108|chr7 (514 aa) initn: 562 init1: 170 opt: 383 Z-score: 317.2 bits: 68.0 E(32554): 2.4e-11 Smith-Waterman score: 620; 32.7% identity (53.2% similar) in 462 aa overlap (3-397:10-463) 10 20 30 40 50 pF1KB5 MGTP--KPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQE-D :: . :. ::::.:.. : :. ::: . : :::.:. :. .:. : CCDS43 MNQSIPVAPTPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGD 10 20 30 40 50 60 60 70 80 90 100 pF1KB5 FGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKD-PHDPHKIYEF ::.:::. :: :. : :. : :: :.: :::... .:: : .: : .:.:::: CCDS43 NTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEV 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB5 VNSGVGDF-SQPDTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGP---P-SLA--- ..: . ::: : . :.. . .:. :...: .. :. . :: : :: CCDS43 CSNGPAPTDSQPPE--DYSFGAGEEEEEEEELQRMLPSLSLTDAVQSGPHMTPYSLLKED 130 140 150 160 170 170 180 190 pF1KB5 VAPEPCPQP--LRSPSLDNPT-------------PFPNLGPSENP------LKRLLVPG- : : :: :: :.:. :: : : : :: :...: :: CCDS43 VKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGFRELLSEVLEPGP 180 190 200 210 220 230 200 210 220 230 pF1KB5 ---------EEW--------------EFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDR :. ..:. :::: ::: :.: :: :.. CCDS43 LPASLPPAGEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLEAT 240 250 260 270 280 290 240 250 260 270 280 pF1KB5 T----LPGWPVTL-----PDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLG : : :..: :.: .:. . :. ..:. : :: : :: :.: :: CCDS43 QEQVELFG-PISLEQVRFPSPEDIPSDKQRF-YTNQLLDVLDRGLILQLQGQDLYAIRLC 300 310 320 330 340 350 290 300 310 320 330 340 pF1KB5 HCHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEG-SGRSPRYALWF .:...:. .: .: . .. . .:.: :. .:: : .: .. : . ..: CCDS43 QCKVFWSGPCASAHDSCPNP---IQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFF 360 370 380 390 400 410 350 360 370 380 390 400 pF1KB5 CVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSD : :: ::. .: :.:. :.:::. : :.:: : : ... :.::: CCDS43 CFGEEWPDRKPREKKLITVQVVPVAARLLLEMFS-GELSWSADSIRLQISNPDLKDRMVE 420 430 440 450 460 470 410 420 pF1KB5 QYKAYLQDLVEGMDFQGPGES CCDS43 QFKELHHIWQSQQRLQPVAQAPPGAGLGVGQGPWPMHPAGMQ 480 490 500 510 >>CCDS1492.1 IRF6 gene_id:3664|Hs108|chr1 (467 aa) initn: 502 init1: 169 opt: 373 Z-score: 309.9 bits: 66.5 E(32554): 6.1e-11 Smith-Waterman score: 623; 31.1% identity (58.1% similar) in 453 aa overlap (7-422:9-446) 10 20 30 40 50 pF1KB5 MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFG-IFQAW :. ::::.:.: : :. :.... ::.:::::. :.. :::. . ::.:: CCDS14 MALHPRRVRLKPWLVAQVDSGLYPGLIWLHRDSKRFQIPWKHATRHSPQQEEENTIFKAW 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 AEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKD-PHDPHKIYEFVNSGVGD : :: : : : :: :: ..: :::... . : : .:. : .: :::. : : CCDS14 AVETGKYQEGVDDPDPAKWKAQLRCALNKSREFNLMYDGTKEVPMNPVKIYQ-----VCD 70 80 90 100 110 120 130 140 150 160 pF1KB5 FSQPDTS---PDTNGGG----STSDT-QEDILDELLGNMVLAPLPDPGPPSLAVAPEP-C . ::. : : ..:.. . .:. .:: ::: .. .:. : : : . : CCDS14 IPQPQGSIINPGSTGSAPWDEKDNDVDEEDEEDELDQSQHHVPIQDTFP-FLNINGSPMA 120 130 140 150 160 170 170 180 190 200 210 pF1KB5 PQPLRSPSLDNPTP---FPNLGPSE-----NPLKRLLVPGEEW-------EFEVTAFYRG : . . :. : .: .:. : : :.. . : : .... ::: CCDS14 PASVGNCSVGNCSPEAVWPKTEPLEMEVPQAPIQPFYSSPELWISSLPMTDLDIKFQYRG 180 190 200 210 220 230 220 230 240 250 260 pF1KB5 RQVFQ-QTISCPEGLRLVGSEVG----DRTLPGWPVTLPD---PG-MSLTDRGVMSYVRH .. : .:.: :.: :: ...: .. : : ::.: . :: .:.. .. . CCDS14 KEYGQTMTVSNPQGCRLFYGDLGPMPDQEELFG-PVSLEQVKFPGPEHITNEKQKLFTSK 240 250 260 270 280 290 270 280 290 300 310 320 pF1KB5 VLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLG .:. . :: : .:. ..: :: .:..:: : : : .:. . ..:. .: : CCDS14 LLDVMDRGLILEVSGHAIYAIRLCQCKVYW--SGPCAP-SLVAPN-LIERQKKVKLFCLE 300 310 320 330 340 330 340 350 360 370 380 pF1KB5 PFIVDLITFTEGS-GRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVG :. :::. .:. ..: . ...: :: ::. .: ..:..:.:.:. : . :: CCDS14 TFLSDLIAHQKGQIEKQPPFEIYLCFGEEWPDGKPLERKLILVQVIPVVARMIYEMFSGD 350 360 370 380 390 400 390 400 410 420 pF1KB5 GASSLEN-TVDLHISNSHPLSLTSDQYKAYLQDLVEGMDFQGPGES . :... .: :.::. .:. : :..: . .. : CCDS14 FTRSFDSGSVRLQISTPD----IKDNIVAQLKQLYRILQTQESWQPMQPTPSMQLPPALP 410 420 430 440 450 460 CCDS14 PQ 427 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 16:14:55 2016 done: Thu Nov 3 16:14:56 2016 Total Scan time: 3.480 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]