FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5190, 588 aa 1>>>pF1KB5190 588 - 588 aa - 588 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.1255+/-0.000358; mu= 7.2480+/- 0.022 mean_var=193.0402+/-39.074, 0's: 0 Z-trim(121.5): 96 B-trim: 937 in 2/57 Lambda= 0.092310 statistics sampled from 38146 (38261) to 38146 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.776), E-opt: 0.2 (0.449), width: 16 Scan time: 10.900 The best scores are: opt bits E(85289) NP_001027568 (OMIM: 300420) E3 ubiquitin-protein l ( 588) 4049 551.8 2.4e-156 XP_005262349 (OMIM: 300420) PREDICTED: E3 ubiquiti ( 588) 4049 551.8 2.4e-156 XP_011529313 (OMIM: 300420) PREDICTED: E3 ubiquiti ( 643) 4049 551.8 2.5e-156 NP_660095 (OMIM: 300420) E3 ubiquitin-protein liga ( 643) 4049 551.8 2.5e-156 NP_071763 (OMIM: 300420) E3 ubiquitin-protein liga ( 455) 2484 343.2 1.1e-93 XP_005259651 (OMIM: 615177) PREDICTED: E3 ubiquiti ( 284) 278 49.3 2.1e-05 NP_919442 (OMIM: 615177) E3 ubiquitin-protein liga ( 311) 278 49.3 2.2e-05 NP_057578 (OMIM: 612490) E3 ubiquitin-protein liga ( 153) 255 46.0 0.00011 >>NP_001027568 (OMIM: 300420) E3 ubiquitin-protein ligas (588 aa) initn: 4049 init1: 4049 opt: 4049 Z-score: 2928.0 bits: 551.8 E(85289): 2.4e-156 Smith-Waterman score: 4049; 100.0% identity (100.0% similar) in 588 aa overlap (1-588:1-588) 10 20 30 40 50 60 pF1KB5 MHRSAPSQTTKRSRSPFSTTRRSWDDSESSGTNLNIDNEDYSRYPPREYRASGSRRGMAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MHRSAPSQTTKRSRSPFSTTRRSWDDSESSGTNLNIDNEDYSRYPPREYRASGSRRGMAY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GHIDSYGADDSEEEGAGPVERPPVRGKTGKFKDDKLYDPEKGARSLAGPPPHFSSFSRDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHIDSYGADDSEEEGAGPVERPPVRGKTGKFKDDKLYDPEKGARSLAGPPPHFSSFSRDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 REERDKLDPVPAARCSASRADFLPQSSVASQSSSEGKLATKGDSSERERREQNLPARPSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REERDKLDPVPAARCSASRADFLPQSSVASQSSSEGKLATKGDSSERERREQNLPARPSR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 APVSICGGGENTSKSAEEPVVRPKIRNLASPNCVKPKIFFDTDDDDDMPHSTSRWRDTAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APVSICGGGENTSKSAEEPVVRPKIRNLASPNCVKPKIFFDTDDDDDMPHSTSRWRDTAN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DNEGHSDGLARRGRGESSSGYPEPKYPEDKREARSDQVKPEKVPRRRRTMADPDFWTHSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DNEGHSDGLARRGRGESSSGYPEPKYPEDKREARSDQVKPEKVPRRRRTMADPDFWTHSD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 DYYKYCDEDSDSDKEWIAALRRKYRSREQTLSSSGESWETLPGKEEREPPQAKVSASTGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DYYKYCDEDSDSDKEWIAALRRKYRSREQTLSSSGESWETLPGKEEREPPQAKVSASTGT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 SPGPGASASAGAGAGASAGSNGSNYLEEVREPSLQEEQASLEEGEIPWLQYHENDSSSEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPGPGASASAGAGAGASAGSNGSNYLEEVREPSLQEEQASLEEGEIPWLQYHENDSSSEG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 DNDSGHELMQPGVFMLDGNNNLEDDSSVSEDLEVDWSLFDGFADGLGVAEAISYVDPQFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DNDSGHELMQPGVFMLDGNNNLEDDSSVSEDLEVDWSLFDGFADGLGVAEAISYVDPQFL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 TYMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TYMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCC 490 500 510 520 530 540 550 560 570 580 pF1KB5 PICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL 550 560 570 580 >>XP_005262349 (OMIM: 300420) PREDICTED: E3 ubiquitin-pr (588 aa) initn: 4049 init1: 4049 opt: 4049 Z-score: 2928.0 bits: 551.8 E(85289): 2.4e-156 Smith-Waterman score: 4049; 100.0% identity (100.0% similar) in 588 aa overlap (1-588:1-588) 10 20 30 40 50 60 pF1KB5 MHRSAPSQTTKRSRSPFSTTRRSWDDSESSGTNLNIDNEDYSRYPPREYRASGSRRGMAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MHRSAPSQTTKRSRSPFSTTRRSWDDSESSGTNLNIDNEDYSRYPPREYRASGSRRGMAY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GHIDSYGADDSEEEGAGPVERPPVRGKTGKFKDDKLYDPEKGARSLAGPPPHFSSFSRDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GHIDSYGADDSEEEGAGPVERPPVRGKTGKFKDDKLYDPEKGARSLAGPPPHFSSFSRDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 REERDKLDPVPAARCSASRADFLPQSSVASQSSSEGKLATKGDSSERERREQNLPARPSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 REERDKLDPVPAARCSASRADFLPQSSVASQSSSEGKLATKGDSSERERREQNLPARPSR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 APVSICGGGENTSKSAEEPVVRPKIRNLASPNCVKPKIFFDTDDDDDMPHSTSRWRDTAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 APVSICGGGENTSKSAEEPVVRPKIRNLASPNCVKPKIFFDTDDDDDMPHSTSRWRDTAN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DNEGHSDGLARRGRGESSSGYPEPKYPEDKREARSDQVKPEKVPRRRRTMADPDFWTHSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DNEGHSDGLARRGRGESSSGYPEPKYPEDKREARSDQVKPEKVPRRRRTMADPDFWTHSD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 DYYKYCDEDSDSDKEWIAALRRKYRSREQTLSSSGESWETLPGKEEREPPQAKVSASTGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DYYKYCDEDSDSDKEWIAALRRKYRSREQTLSSSGESWETLPGKEEREPPQAKVSASTGT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 SPGPGASASAGAGAGASAGSNGSNYLEEVREPSLQEEQASLEEGEIPWLQYHENDSSSEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SPGPGASASAGAGAGASAGSNGSNYLEEVREPSLQEEQASLEEGEIPWLQYHENDSSSEG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 DNDSGHELMQPGVFMLDGNNNLEDDSSVSEDLEVDWSLFDGFADGLGVAEAISYVDPQFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DNDSGHELMQPGVFMLDGNNNLEDDSSVSEDLEVDWSLFDGFADGLGVAEAISYVDPQFL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 TYMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TYMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCC 490 500 510 520 530 540 550 560 570 580 pF1KB5 PICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL :::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL 550 560 570 580 >>XP_011529313 (OMIM: 300420) PREDICTED: E3 ubiquitin-pr (643 aa) initn: 4049 init1: 4049 opt: 4049 Z-score: 2927.4 bits: 551.8 E(85289): 2.5e-156 Smith-Waterman score: 4049; 100.0% identity (100.0% similar) in 588 aa overlap (1-588:56-643) 10 20 30 pF1KB5 MHRSAPSQTTKRSRSPFSTTRRSWDDSESS :::::::::::::::::::::::::::::: XP_011 GRRHAYVSFRPPTSQRERIASQRKTNSEVPMHRSAPSQTTKRSRSPFSTTRRSWDDSESS 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB5 GTNLNIDNEDYSRYPPREYRASGSRRGMAYGHIDSYGADDSEEEGAGPVERPPVRGKTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTNLNIDNEDYSRYPPREYRASGSRRGMAYGHIDSYGADDSEEEGAGPVERPPVRGKTGK 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB5 FKDDKLYDPEKGARSLAGPPPHFSSFSRDVREERDKLDPVPAARCSASRADFLPQSSVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FKDDKLYDPEKGARSLAGPPPHFSSFSRDVREERDKLDPVPAARCSASRADFLPQSSVAS 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB5 QSSSEGKLATKGDSSERERREQNLPARPSRAPVSICGGGENTSKSAEEPVVRPKIRNLAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSSSEGKLATKGDSSERERREQNLPARPSRAPVSICGGGENTSKSAEEPVVRPKIRNLAS 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB5 PNCVKPKIFFDTDDDDDMPHSTSRWRDTANDNEGHSDGLARRGRGESSSGYPEPKYPEDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PNCVKPKIFFDTDDDDDMPHSTSRWRDTANDNEGHSDGLARRGRGESSSGYPEPKYPEDK 270 280 290 300 310 320 280 290 300 310 320 330 pF1KB5 REARSDQVKPEKVPRRRRTMADPDFWTHSDDYYKYCDEDSDSDKEWIAALRRKYRSREQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REARSDQVKPEKVPRRRRTMADPDFWTHSDDYYKYCDEDSDSDKEWIAALRRKYRSREQT 330 340 350 360 370 380 340 350 360 370 380 390 pF1KB5 LSSSGESWETLPGKEEREPPQAKVSASTGTSPGPGASASAGAGAGASAGSNGSNYLEEVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSSSGESWETLPGKEEREPPQAKVSASTGTSPGPGASASAGAGAGASAGSNGSNYLEEVR 390 400 410 420 430 440 400 410 420 430 440 450 pF1KB5 EPSLQEEQASLEEGEIPWLQYHENDSSSEGDNDSGHELMQPGVFMLDGNNNLEDDSSVSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EPSLQEEQASLEEGEIPWLQYHENDSSSEGDNDSGHELMQPGVFMLDGNNNLEDDSSVSE 450 460 470 480 490 500 460 470 480 490 500 510 pF1KB5 DLEVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAVDVEVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLEVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAVDVEVA 510 520 530 540 550 560 520 530 540 550 560 570 pF1KB5 NPPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVATELPCHHYFHKPCVSIW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVATELPCHHYFHKPCVSIW 570 580 590 600 610 620 580 pF1KB5 LQKSGTCPVCRCMFPPPL :::::::::::::::::: XP_011 LQKSGTCPVCRCMFPPPL 630 640 >>NP_660095 (OMIM: 300420) E3 ubiquitin-protein ligase P (643 aa) initn: 4049 init1: 4049 opt: 4049 Z-score: 2927.4 bits: 551.8 E(85289): 2.5e-156 Smith-Waterman score: 4049; 100.0% identity (100.0% similar) in 588 aa overlap (1-588:56-643) 10 20 30 pF1KB5 MHRSAPSQTTKRSRSPFSTTRRSWDDSESS :::::::::::::::::::::::::::::: NP_660 GRRHAYVSFRPPTSQRERIASQRKTNSEVPMHRSAPSQTTKRSRSPFSTTRRSWDDSESS 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB5 GTNLNIDNEDYSRYPPREYRASGSRRGMAYGHIDSYGADDSEEEGAGPVERPPVRGKTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 GTNLNIDNEDYSRYPPREYRASGSRRGMAYGHIDSYGADDSEEEGAGPVERPPVRGKTGK 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB5 FKDDKLYDPEKGARSLAGPPPHFSSFSRDVREERDKLDPVPAARCSASRADFLPQSSVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 FKDDKLYDPEKGARSLAGPPPHFSSFSRDVREERDKLDPVPAARCSASRADFLPQSSVAS 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB5 QSSSEGKLATKGDSSERERREQNLPARPSRAPVSICGGGENTSKSAEEPVVRPKIRNLAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 QSSSEGKLATKGDSSERERREQNLPARPSRAPVSICGGGENTSKSAEEPVVRPKIRNLAS 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB5 PNCVKPKIFFDTDDDDDMPHSTSRWRDTANDNEGHSDGLARRGRGESSSGYPEPKYPEDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 PNCVKPKIFFDTDDDDDMPHSTSRWRDTANDNEGHSDGLARRGRGESSSGYPEPKYPEDK 270 280 290 300 310 320 280 290 300 310 320 330 pF1KB5 REARSDQVKPEKVPRRRRTMADPDFWTHSDDYYKYCDEDSDSDKEWIAALRRKYRSREQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 REARSDQVKPEKVPRRRRTMADPDFWTHSDDYYKYCDEDSDSDKEWIAALRRKYRSREQT 330 340 350 360 370 380 340 350 360 370 380 390 pF1KB5 LSSSGESWETLPGKEEREPPQAKVSASTGTSPGPGASASAGAGAGASAGSNGSNYLEEVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 LSSSGESWETLPGKEEREPPQAKVSASTGTSPGPGASASAGAGAGASAGSNGSNYLEEVR 390 400 410 420 430 440 400 410 420 430 440 450 pF1KB5 EPSLQEEQASLEEGEIPWLQYHENDSSSEGDNDSGHELMQPGVFMLDGNNNLEDDSSVSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 EPSLQEEQASLEEGEIPWLQYHENDSSSEGDNDSGHELMQPGVFMLDGNNNLEDDSSVSE 450 460 470 480 490 500 460 470 480 490 500 510 pF1KB5 DLEVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAVDVEVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 DLEVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAVDVEVA 510 520 530 540 550 560 520 530 540 550 560 570 pF1KB5 NPPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVATELPCHHYFHKPCVSIW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 NPPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVATELPCHHYFHKPCVSIW 570 580 590 600 610 620 580 pF1KB5 LQKSGTCPVCRCMFPPPL :::::::::::::::::: NP_660 LQKSGTCPVCRCMFPPPL 630 640 >>NP_071763 (OMIM: 300420) E3 ubiquitin-protein ligase P (455 aa) initn: 2742 init1: 2477 opt: 2484 Z-score: 1803.1 bits: 343.2 E(85289): 1.1e-93 Smith-Waterman score: 2484; 98.6% identity (99.5% similar) in 365 aa overlap (224-588:92-455) 200 210 220 230 240 250 pF1KB5 KSAEEPVVRPKIRNLASPNCVKPKIFFDTDDDDDMPHSTSRWRDTANDNEGHSDGLARRG :..:. ::::::::::::::::::::::: NP_071 SQTTKRSRSPFSTTRRSWDDSESSGTNLNIDNEDYS-STSRWRDTANDNEGHSDGLARRG 70 80 90 100 110 120 260 270 280 290 300 310 pF1KB5 RGESSSGYPEPKYPEDKREARSDQVKPEKVPRRRRTMADPDFWTHSDDYYKYCDEDSDSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 RGESSSGYPEPKYPEDKREARSDQVKPEKVPRRRRTMADPDFWTHSDDYYKYCDEDSDSD 130 140 150 160 170 180 320 330 340 350 360 370 pF1KB5 KEWIAALRRKYRSREQTLSSSGESWETLPGKEEREPPQAKVSASTGTSPGPGASASAGAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 KEWIAALRRKYRSREQTLSSSGESWETLPGKEEREPPQAKVSASTGTSPGPGASASAGAG 190 200 210 220 230 240 380 390 400 410 420 430 pF1KB5 AGASAGSNGSNYLEEVREPSLQEEQASLEEGEIPWLQYHENDSSSEGDNDSGHELMQPGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 AGASAGSNGSNYLEEVREPSLQEEQASLEEGEIPWLQYHENDSSSEGDNDSGHELMQPGV 250 260 270 280 290 300 440 450 460 470 480 490 pF1KB5 FMLDGNNNLEDDSSVSEDLEVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 FMLDGNNNLEDDSSVSEDLEVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAM 310 320 330 340 350 360 500 510 520 530 540 550 pF1KB5 ETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 ETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVA 370 380 390 400 410 420 560 570 580 pF1KB5 TELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL ::::::::::::::::::::::::::::::::::: NP_071 TELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL 430 440 450 >>XP_005259651 (OMIM: 615177) PREDICTED: E3 ubiquitin-pr (284 aa) initn: 302 init1: 203 opt: 278 Z-score: 218.1 bits: 49.3 E(85289): 2.1e-05 Smith-Waterman score: 278; 50.0% identity (75.7% similar) in 70 aa overlap (512-581:176-243) 490 500 510 520 530 540 pF1KB5 YMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCP :::.::.:.::: . :::.: ::. . :: XP_005 HSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEH--VGSGLECP 150 160 170 180 190 200 550 560 570 580 pF1KB5 ICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL .: ..:. :: . .:::.: :: :. ::.. .::::: XP_005 VCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSF 210 220 230 240 250 260 XP_005 SSSSSSSSSSSPSNENATSNS 270 280 >>NP_919442 (OMIM: 615177) E3 ubiquitin-protein ligase R (311 aa) initn: 302 init1: 203 opt: 278 Z-score: 217.6 bits: 49.3 E(85289): 2.2e-05 Smith-Waterman score: 278; 50.0% identity (75.7% similar) in 70 aa overlap (512-581:203-270) 490 500 510 520 530 540 pF1KB5 YMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCP :::.::.:.::: . :::.: ::. . :: NP_919 HSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEH--VGSGLECP 180 190 200 210 220 230 550 560 570 580 pF1KB5 ICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL .: ..:. :: . .:::.: :: :. ::.. .::::: NP_919 VCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSF 240 250 260 270 280 290 NP_919 SSSSSSSSSSSPSNENATSNS 300 310 >>NP_057578 (OMIM: 612490) E3 ubiquitin-protein ligase R (153 aa) initn: 248 init1: 209 opt: 255 Z-score: 205.1 bits: 46.0 E(85289): 0.00011 Smith-Waterman score: 255; 32.7% identity (65.5% similar) in 113 aa overlap (476-585:14-121) 450 460 470 480 490 500 pF1KB5 SSVSEDLEVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAV ::. : . .::... . . .:.:.. NP_057 MASYFDEHDCEPSDPEQETRTNMLLELARSLFNRM-DFEDLGL 10 20 30 40 510 520 530 540 550 560 pF1KB5 DVEVAN---PPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVATELPCHHYF :. . :::.: .. ::. .. ... :. ::.: :. . :.: :.:::: : NP_057 VVDWDHHLPPPAAKTVVENLPRTVIRGSQA----ELKCPVCLLEFEEEETAIEMPCHHLF 50 60 70 80 90 570 580 pF1KB5 HKPCVSIWLQKSGTCPVCRCMFPPPL :. :. ::.:...::.:: .: NP_057 HSSCILPWLSKTNSCPLCRYELPTDDDTYEEHRRDKARKQQQQHRLENLHGAMYT 100 110 120 130 140 150 588 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 22:21:09 2016 done: Fri Nov 4 22:21:11 2016 Total Scan time: 10.900 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]