FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5211, 378 aa 1>>>pF1KB5211 378 - 378 aa - 378 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9333+/-0.000398; mu= 18.3897+/- 0.025 mean_var=65.3167+/-13.523, 0's: 0 Z-trim(112.1): 70 B-trim: 964 in 2/52 Lambda= 0.158695 statistics sampled from 20845 (20925) to 20845 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.245), width: 16 Scan time: 7.910 The best scores are: opt bits E(85289) NP_002174 (OMIM: 308385,430000) interleukin-3 rece ( 378) 2607 605.9 4.8e-173 XP_005274837 (OMIM: 308385,430000) PREDICTED: inte ( 378) 2607 605.9 4.8e-173 XP_005274488 (OMIM: 308385,430000) PREDICTED: inte ( 378) 2607 605.9 4.8e-173 XP_016884980 (OMIM: 308385,430000) PREDICTED: inte ( 377) 2584 600.7 1.8e-171 XP_005274489 (OMIM: 308385,430000) PREDICTED: inte ( 377) 2584 600.7 1.8e-171 XP_016885532 (OMIM: 308385,430000) PREDICTED: inte ( 377) 2584 600.7 1.8e-171 XP_005274838 (OMIM: 308385,430000) PREDICTED: inte ( 377) 2584 600.7 1.8e-171 NP_001254642 (OMIM: 308385,430000) interleukin-3 r ( 300) 1926 450.0 3.4e-126 NP_006131 (OMIM: 306250,425000) granulocyte-macrop ( 400) 590 144.2 5.1e-34 NP_001155001 (OMIM: 306250,425000) granulocyte-mac ( 400) 590 144.2 5.1e-34 XP_011544468 (OMIM: 306250,425000) PREDICTED: gran ( 400) 590 144.2 5.1e-34 NP_758448 (OMIM: 306250,425000) granulocyte-macrop ( 400) 590 144.2 5.1e-34 XP_011543921 (OMIM: 306250,425000) PREDICTED: gran ( 400) 590 144.2 5.1e-34 XP_011543924 (OMIM: 306250,425000) PREDICTED: gran ( 385) 568 139.1 1.6e-32 XP_011544471 (OMIM: 306250,425000) PREDICTED: gran ( 385) 568 139.1 1.6e-32 XP_011544469 (OMIM: 306250,425000) PREDICTED: gran ( 389) 568 139.1 1.7e-32 XP_011543922 (OMIM: 306250,425000) PREDICTED: gran ( 389) 568 139.1 1.7e-32 XP_011543923 (OMIM: 306250,425000) PREDICTED: gran ( 386) 567 138.9 1.9e-32 XP_011544470 (OMIM: 306250,425000) PREDICTED: gran ( 386) 567 138.9 1.9e-32 XP_011543925 (OMIM: 306250,425000) PREDICTED: gran ( 383) 566 138.7 2.2e-32 XP_016885517 (OMIM: 306250,425000) PREDICTED: gran ( 383) 566 138.7 2.2e-32 XP_011544472 (OMIM: 306250,425000) PREDICTED: gran ( 383) 566 138.7 2.2e-32 XP_016884776 (OMIM: 306250,425000) PREDICTED: gran ( 383) 566 138.7 2.2e-32 XP_011543920 (OMIM: 306250,425000) PREDICTED: gran ( 410) 566 138.7 2.4e-32 NP_001155003 (OMIM: 306250,425000) granulocyte-mac ( 410) 566 138.7 2.4e-32 XP_011544467 (OMIM: 306250,425000) PREDICTED: gran ( 410) 566 138.7 2.4e-32 NP_758449 (OMIM: 306250,425000) granulocyte-macrop ( 377) 472 117.1 6.7e-26 NP_758450 (OMIM: 306250,425000) granulocyte-macrop ( 333) 471 116.9 7.1e-26 XP_016885518 (OMIM: 306250,425000) PREDICTED: gran ( 333) 471 116.9 7.1e-26 XP_011544477 (OMIM: 306250,425000) PREDICTED: gran ( 333) 471 116.9 7.1e-26 XP_011543930 (OMIM: 306250,425000) PREDICTED: gran ( 333) 471 116.9 7.1e-26 XP_016884777 (OMIM: 306250,425000) PREDICTED: gran ( 333) 471 116.9 7.1e-26 XP_011543929 (OMIM: 306250,425000) PREDICTED: gran ( 333) 471 116.9 7.1e-26 XP_011544475 (OMIM: 306250,425000) PREDICTED: gran ( 333) 471 116.9 7.1e-26 XP_011544476 (OMIM: 306250,425000) PREDICTED: gran ( 333) 471 116.9 7.1e-26 XP_011543928 (OMIM: 306250,425000) PREDICTED: gran ( 333) 471 116.9 7.1e-26 NP_001155002 (OMIM: 306250,425000) granulocyte-mac ( 434) 471 116.9 8.7e-26 NP_001155004 (OMIM: 306250,425000) granulocyte-mac ( 267) 442 110.2 5.9e-24 NP_758452 (OMIM: 306250,425000) granulocyte-macrop ( 233) 364 92.3 1.3e-18 NP_783853 (OMIM: 147851) interleukin-5 receptor su ( 420) 294 76.4 1.3e-13 NP_000555 (OMIM: 147851) interleukin-5 receptor su ( 420) 294 76.4 1.3e-13 XP_011531980 (OMIM: 147851) PREDICTED: interleukin ( 439) 286 74.6 5e-13 XP_011531979 (OMIM: 147851) PREDICTED: interleukin ( 439) 286 74.6 5e-13 NP_001230028 (OMIM: 147851) interleukin-5 receptor ( 378) 246 65.4 2.5e-10 NP_783854 (OMIM: 147851) interleukin-5 receptor su ( 333) 226 60.8 5.4e-09 NP_783851 (OMIM: 147851) interleukin-5 receptor su ( 333) 226 60.8 5.4e-09 NP_783852 (OMIM: 147851) interleukin-5 receptor su ( 335) 226 60.8 5.5e-09 NP_783855 (OMIM: 147851) interleukin-5 receptor su ( 335) 226 60.8 5.5e-09 NP_000631 (OMIM: 300130) interleukin-13 receptor s ( 380) 200 54.9 3.7e-07 NP_000386 (OMIM: 138981,614370) cytokine receptor ( 897) 168 47.8 0.00012 >>NP_002174 (OMIM: 308385,430000) interleukin-3 receptor (378 aa) initn: 2607 init1: 2607 opt: 2607 Z-score: 3227.7 bits: 605.9 E(85289): 4.8e-173 Smith-Waterman score: 2607; 100.0% identity (100.0% similar) in 378 aa overlap (1-378:1-378) 10 20 30 40 50 60 pF1KB5 MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 SCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG 310 320 330 340 350 360 370 pF1KB5 KAGLEECLVTEVQVVQKT :::::::::::::::::: NP_002 KAGLEECLVTEVQVVQKT 370 >>XP_005274837 (OMIM: 308385,430000) PREDICTED: interleu (378 aa) initn: 2607 init1: 2607 opt: 2607 Z-score: 3227.7 bits: 605.9 E(85289): 4.8e-173 Smith-Waterman score: 2607; 100.0% identity (100.0% similar) in 378 aa overlap (1-378:1-378) 10 20 30 40 50 60 pF1KB5 MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 SCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG 310 320 330 340 350 360 370 pF1KB5 KAGLEECLVTEVQVVQKT :::::::::::::::::: XP_005 KAGLEECLVTEVQVVQKT 370 >>XP_005274488 (OMIM: 308385,430000) PREDICTED: interleu (378 aa) initn: 2607 init1: 2607 opt: 2607 Z-score: 3227.7 bits: 605.9 E(85289): 4.8e-173 Smith-Waterman score: 2607; 100.0% identity (100.0% similar) in 378 aa overlap (1-378:1-378) 10 20 30 40 50 60 pF1KB5 MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 SCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG 310 320 330 340 350 360 370 pF1KB5 KAGLEECLVTEVQVVQKT :::::::::::::::::: XP_005 KAGLEECLVTEVQVVQKT 370 >>XP_016884980 (OMIM: 308385,430000) PREDICTED: interleu (377 aa) initn: 1590 init1: 1590 opt: 2584 Z-score: 3199.3 bits: 600.7 E(85289): 1.8e-171 Smith-Waterman score: 2584; 99.5% identity (99.7% similar) in 378 aa overlap (1-378:1-377) 10 20 30 40 50 60 pF1KB5 MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 SCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS ::::::::::::::::::::::: .::::::::::::::::::::::::::::::::::: XP_016 SCSWAVGPGAPADVQYDLYLNVA-KRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS 130 140 150 160 170 190 200 210 220 230 240 pF1KB5 HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB5 QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB5 TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG 300 310 320 330 340 350 370 pF1KB5 KAGLEECLVTEVQVVQKT :::::::::::::::::: XP_016 KAGLEECLVTEVQVVQKT 360 370 >>XP_005274489 (OMIM: 308385,430000) PREDICTED: interleu (377 aa) initn: 1590 init1: 1590 opt: 2584 Z-score: 3199.3 bits: 600.7 E(85289): 1.8e-171 Smith-Waterman score: 2584; 99.5% identity (99.7% similar) in 378 aa overlap (1-378:1-377) 10 20 30 40 50 60 pF1KB5 MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 SCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS ::::::::::::::::::::::: .::::::::::::::::::::::::::::::::::: XP_005 SCSWAVGPGAPADVQYDLYLNVA-KRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS 130 140 150 160 170 190 200 210 220 230 240 pF1KB5 HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB5 QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB5 TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG 300 310 320 330 340 350 370 pF1KB5 KAGLEECLVTEVQVVQKT :::::::::::::::::: XP_005 KAGLEECLVTEVQVVQKT 360 370 >>XP_016885532 (OMIM: 308385,430000) PREDICTED: interleu (377 aa) initn: 1590 init1: 1590 opt: 2584 Z-score: 3199.3 bits: 600.7 E(85289): 1.8e-171 Smith-Waterman score: 2584; 99.5% identity (99.7% similar) in 378 aa overlap (1-378:1-377) 10 20 30 40 50 60 pF1KB5 MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 SCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS ::::::::::::::::::::::: .::::::::::::::::::::::::::::::::::: XP_016 SCSWAVGPGAPADVQYDLYLNVA-KRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS 130 140 150 160 170 190 200 210 220 230 240 pF1KB5 HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB5 QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB5 TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG 300 310 320 330 340 350 370 pF1KB5 KAGLEECLVTEVQVVQKT :::::::::::::::::: XP_016 KAGLEECLVTEVQVVQKT 360 370 >>XP_005274838 (OMIM: 308385,430000) PREDICTED: interleu (377 aa) initn: 1590 init1: 1590 opt: 2584 Z-score: 3199.3 bits: 600.7 E(85289): 1.8e-171 Smith-Waterman score: 2584; 99.5% identity (99.7% similar) in 378 aa overlap (1-378:1-377) 10 20 30 40 50 60 pF1KB5 MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 SCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS ::::::::::::::::::::::: .::::::::::::::::::::::::::::::::::: XP_005 SCSWAVGPGAPADVQYDLYLNVA-KRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS 130 140 150 160 170 190 200 210 220 230 240 pF1KB5 HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB5 QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB5 TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG 300 310 320 330 340 350 370 pF1KB5 KAGLEECLVTEVQVVQKT :::::::::::::::::: XP_005 KAGLEECLVTEVQVVQKT 360 370 >>NP_001254642 (OMIM: 308385,430000) interleukin-3 recep (300 aa) initn: 1924 init1: 1924 opt: 1926 Z-score: 2386.5 bits: 450.0 E(85289): 3.4e-126 Smith-Waterman score: 1926; 97.9% identity (99.3% similar) in 285 aa overlap (94-378:16-300) 70 80 90 100 110 120 pF1KB5 NNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFLSCS .: ...::::::::::::::::::::::: NP_001 MVLLWLTLLLIALPCLLQTKEGGKPWAGAENLTCWIHDVDFLSCS 10 20 30 40 130 140 150 160 170 180 pF1KB5 WAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSSHIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSSHIL 50 60 70 80 90 100 190 200 210 220 230 240 pF1KB5 VRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYELQIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYELQIQ 110 120 130 140 150 160 250 260 270 280 290 300 pF1KB5 KRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGANTRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGANTRA 170 180 190 200 210 220 310 320 330 340 350 360 pF1KB5 WRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAGKAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAGKAG 230 240 250 260 270 280 370 pF1KB5 LEECLVTEVQVVQKT ::::::::::::::: NP_001 LEECLVTEVQVVQKT 290 300 >>NP_006131 (OMIM: 306250,425000) granulocyte-macrophage (400 aa) initn: 506 init1: 210 opt: 590 Z-score: 731.7 bits: 144.2 E(85289): 5.1e-34 Smith-Waterman score: 643; 31.9% identity (63.0% similar) in 408 aa overlap (1-372:1-399) 10 20 30 40 50 pF1KB5 MVLLWLTLLLIALP----CLLQTKED--PNPPIT--NLRMKAKAQQLTWDLNRNVTDIEC :.:: .::: :: :. : : : . :.:. .....:.:: ..:.: .: NP_006 MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKC 10 20 30 40 50 60 60 70 80 90 100 pF1KB5 V---KDADYSMPAVNNSYCQ--FGAISLCEVTNYTVRVANPP--FSTWILFPENSGKPWA : : ..:. :. : : : : ... :.: . :. .:.: :::. . NP_006 FLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYP-NSGREGT 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 GAENLTCWIHDVDFLSCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGC .:.:..:.:...:...:.:: :: :: :::: ::. ..::.. .: .: :. ::..:: NP_006 AAQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDS-GTHVGC 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 RFDDISRLSSGSQSSHILVRGRSAAFGIPCTDKFVVFSQIEILTPP-NMTAKCNKTHSFM ..:..: :.: ...:: : : .:: :... ..:: ..:: :.:..:: :: .. NP_006 HLDNLSGLTS---RNYFLVNGTSREIGIQFFDSLLDTKKIERFNPPSNVTVRCNTTHCLV 180 190 200 210 220 230 230 240 250 260 270 pF1KB5 HWKMRSHFNR----KFRYELQIQKR-MQP-------VITEQVRDRTSFQLLNP-GTYTVQ .::. ... :.:.:..... :: .. ....: .: .: . ..:. NP_006 RWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENRYNFPSSEPRAKHSVK 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB5 IRARE-RVYEFLSAWSTPQRFECDQEEGANTRAWRTSLLIALGTLLALVCVFVICRRYLV ::: . :. .. :.:: .: : .: : . .:. .:::. . . . .:.: NP_006 IRAADVRILNW-SSWSEAIEFGSD--DG-NLGSVYIYVLLIVGTLVCGIVLGFLFKRFLR 300 310 320 330 340 350 340 350 360 370 pF1KB5 MQRLFPRIPHMKDPIGDSFQNDKLVVWEA-----GKAGLEECL-VTEVQVVQKT .::::: .:..:: ..:. . . ..:: ::. :: : : :. NP_006 IQRLFPPVPQIKDKLNDNHEVEDEIIWEEFTPEEGKGYREEVLTVKEIT 360 370 380 390 400 >>NP_001155001 (OMIM: 306250,425000) granulocyte-macroph (400 aa) initn: 506 init1: 210 opt: 590 Z-score: 731.7 bits: 144.2 E(85289): 5.1e-34 Smith-Waterman score: 643; 31.9% identity (63.0% similar) in 408 aa overlap (1-372:1-399) 10 20 30 40 50 pF1KB5 MVLLWLTLLLIALP----CLLQTKED--PNPPIT--NLRMKAKAQQLTWDLNRNVTDIEC :.:: .::: :: :. : : : . :.:. .....:.:: ..:.: .: NP_001 MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKC 10 20 30 40 50 60 60 70 80 90 100 pF1KB5 V---KDADYSMPAVNNSYCQ--FGAISLCEVTNYTVRVANPP--FSTWILFPENSGKPWA : : ..:. :. : : : : ... :.: . :. .:.: :::. . NP_001 FLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYP-NSGREGT 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 GAENLTCWIHDVDFLSCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGC .:.:..:.:...:...:.:: :: :: :::: ::. ..::.. .: .: :. ::..:: NP_001 AAQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDS-GTHVGC 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 RFDDISRLSSGSQSSHILVRGRSAAFGIPCTDKFVVFSQIEILTPP-NMTAKCNKTHSFM ..:..: :.: ...:: : : .:: :... ..:: ..:: :.:..:: :: .. NP_001 HLDNLSGLTS---RNYFLVNGTSREIGIQFFDSLLDTKKIERFNPPSNVTVRCNTTHCLV 180 190 200 210 220 230 230 240 250 260 270 pF1KB5 HWKMRSHFNR----KFRYELQIQKR-MQP-------VITEQVRDRTSFQLLNP-GTYTVQ .::. ... :.:.:..... :: .. ....: .: .: . ..:. NP_001 RWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENRYNFPSSEPRAKHSVK 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB5 IRARE-RVYEFLSAWSTPQRFECDQEEGANTRAWRTSLLIALGTLLALVCVFVICRRYLV ::: . :. .. :.:: .: : .: : . .:. .:::. . . . .:.: NP_001 IRAADVRILNW-SSWSEAIEFGSD--DG-NLGSVYIYVLLIVGTLVCGIVLGFLFKRFLR 300 310 320 330 340 350 340 350 360 370 pF1KB5 MQRLFPRIPHMKDPIGDSFQNDKLVVWEA-----GKAGLEECL-VTEVQVVQKT .::::: .:..:: ..:. . . ..:: ::. :: : : :. NP_001 IQRLFPPVPQIKDKLNDNHEVEDEIIWEEFTPEEGKGYREEVLTVKEIT 360 370 380 390 400 378 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 03:26:10 2016 done: Fri Nov 4 03:26:11 2016 Total Scan time: 7.910 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]