FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5213, 145 aa 1>>>pF1KB5213 145 - 145 aa - 145 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.5938+/-0.000269; mu= 15.4160+/- 0.017 mean_var=59.4097+/-11.906, 0's: 0 Z-trim(119.7): 98 B-trim: 240 in 2/51 Lambda= 0.166397 statistics sampled from 33967 (34078) to 33967 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.785), E-opt: 0.2 (0.4), width: 16 Scan time: 4.440 The best scores are: opt bits E(85289) NP_003341 (OMIM: 603001) ubiquitin-conjugating enz ( 145) 977 241.9 2.8e-64 XP_011515885 (OMIM: 603001) PREDICTED: ubiquitin-c ( 173) 950 235.4 2.8e-62 XP_016869297 (OMIM: 603001) PREDICTED: ubiquitin-c ( 142) 942 233.5 9.3e-62 NP_001027459 (OMIM: 602995) ubiquitin-conjugating ( 147) 886 220.0 1.1e-57 NP_001244322 (OMIM: 602995) ubiquitin-conjugating ( 170) 881 218.9 2.7e-57 NP_954595 (OMIM: 602995) ubiquitin-conjugating enz ( 170) 881 218.9 2.7e-57 NP_068823 (OMIM: 602995) ubiquitin-conjugating enz ( 170) 881 218.9 2.7e-57 NP_001244324 (OMIM: 602995) ubiquitin-conjugating ( 144) 877 217.9 4.7e-57 XP_005251357 (OMIM: 603001) PREDICTED: ubiquitin-c ( 105) 711 177.9 3.6e-45 NP_001244327 (OMIM: 602995) ubiquitin-conjugating ( 105) 642 161.3 3.5e-40 NP_001244328 (OMIM: 602995) ubiquitin-conjugating ( 105) 642 161.3 3.5e-40 NP_001244326 (OMIM: 602995) ubiquitin-conjugating ( 105) 642 161.3 3.5e-40 NP_001269508 (OMIM: 602995) ubiquitin-conjugating ( 105) 642 161.3 3.5e-40 NP_001269505 (OMIM: 602995) ubiquitin-conjugating ( 105) 642 161.3 3.5e-40 NP_071887 (OMIM: 602995) ubiquitin-conjugating enz ( 103) 540 136.8 8.2e-33 NP_001244323 (OMIM: 602995) ubiquitin-conjugating ( 103) 540 136.8 8.2e-33 NP_001269504 (OMIM: 602995) ubiquitin-conjugating ( 91) 533 135.1 2.4e-32 NP_001269506 (OMIM: 602995) ubiquitin-conjugating ( 91) 533 135.1 2.4e-32 NP_001269507 (OMIM: 602995) ubiquitin-conjugating ( 91) 533 135.1 2.4e-32 NP_001269509 (OMIM: 602995) ubiquitin-conjugating ( 64) 353 91.8 1.8e-19 NP_001244325 (OMIM: 602995) ubiquitin-conjugating ( 105) 355 92.4 1.9e-19 NP_001104582 (OMIM: 602846) ubiquitin-conjugating ( 157) 191 53.2 1.9e-07 NP_005330 (OMIM: 602846) ubiquitin-conjugating enz ( 200) 191 53.3 2.2e-07 NP_054895 (OMIM: 610538,616435) ubiquitin-conjugat ( 197) 173 49.0 4.4e-06 NP_003327 (OMIM: 300860,312180) ubiquitin-conjugat ( 152) 166 47.2 1.2e-05 NP_003328 (OMIM: 179095) ubiquitin-conjugating enz ( 152) 162 46.2 2.3e-05 NP_003333 (OMIM: 601569) ubiquitin-conjugating enz ( 170) 158 45.3 4.8e-05 NP_003329 (OMIM: 602961) ubiquitin-conjugating enz ( 147) 157 45.0 5.1e-05 NP_001269090 (OMIM: 300860,312180) ubiquitin-conju ( 119) 155 44.5 6e-05 NP_001297255 (OMIM: 610538,616435) ubiquitin-conju ( 167) 155 44.6 7.8e-05 NP_003332 (OMIM: 602916) ubiquitin-conjugating enz ( 193) 155 44.6 8.7e-05 NP_001189405 (OMIM: 602916) ubiquitin-conjugating ( 160) 153 44.1 0.00011 XP_005265488 (OMIM: 602916) PREDICTED: ubiquitin-c ( 167) 153 44.1 0.00011 NP_872607 (OMIM: 602916) ubiquitin-conjugating enz ( 176) 152 43.9 0.00013 XP_005265490 (OMIM: 602163) PREDICTED: ubiquitin-c ( 189) 152 43.9 0.00014 NP_689866 (OMIM: 602163) ubiquitin-conjugating enz ( 201) 152 43.9 0.00015 XP_005265489 (OMIM: 602163) PREDICTED: ubiquitin-c ( 201) 152 43.9 0.00015 NP_004214 (OMIM: 603890) ubiquitin/ISG15-conjugati ( 153) 148 42.9 0.00023 XP_011534190 (OMIM: 616175) PREDICTED: ubiquitin-c ( 235) 149 43.3 0.00028 XP_011534189 (OMIM: 616175) PREDICTED: ubiquitin-c ( 278) 149 43.3 0.00031 NP_057105 (OMIM: 616175) ubiquitin-conjugating enz ( 318) 149 43.4 0.00035 NP_008950 (OMIM: 605574) ubiquitin-conjugating enz ( 179) 146 42.4 0.00037 NP_003338 (OMIM: 603721) ubiquitin-conjugating enz ( 154) 144 41.9 0.00046 NP_861517 (OMIM: 605574) ubiquitin-conjugating enz ( 140) 141 41.2 0.0007 XP_005246301 (OMIM: 604151) PREDICTED: ubiquitin-c ( 207) 141 41.3 0.00095 NP_001265483 (OMIM: 604151) ubiquitin-conjugating ( 207) 141 41.3 0.00095 NP_872619 (OMIM: 604151) ubiquitin-conjugating enz ( 207) 141 41.3 0.00095 NP_001265484 (OMIM: 604151) ubiquitin-conjugating ( 207) 141 41.3 0.00095 NP_006348 (OMIM: 604151) ubiquitin-conjugating enz ( 207) 141 41.3 0.00095 NP_862821 (OMIM: 602962) ubiquitin-conjugating enz ( 118) 136 39.9 0.0014 >>NP_003341 (OMIM: 603001) ubiquitin-conjugating enzyme (145 aa) initn: 977 init1: 977 opt: 977 Z-score: 1275.0 bits: 241.9 E(85289): 2.8e-64 Smith-Waterman score: 977; 100.0% identity (100.0% similar) in 145 aa overlap (1-145:1-145) 10 20 30 40 50 60 pF1KB5 MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYEN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 RIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQ 70 80 90 100 110 120 130 140 pF1KB5 ELRRLMMSKENMKLPQPPEGQTYNN ::::::::::::::::::::::::: NP_003 ELRRLMMSKENMKLPQPPEGQTYNN 130 140 >>XP_011515885 (OMIM: 603001) PREDICTED: ubiquitin-conju (173 aa) initn: 950 init1: 950 opt: 950 Z-score: 1239.0 bits: 235.4 E(85289): 2.8e-62 Smith-Waterman score: 950; 100.0% identity (100.0% similar) in 140 aa overlap (6-145:34-173) 10 20 30 pF1KB5 MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGL :::::::::::::::::::::::::::::: XP_011 GAHVEEEETAGDKDVEEGVPFPGELVWNREGVKVPRNFRLLEELEEGQKGVGDGTVSWGL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 EDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSS 70 80 90 100 110 120 100 110 120 130 140 pF1KB5 GMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN 130 140 150 160 170 >>XP_016869297 (OMIM: 603001) PREDICTED: ubiquitin-conju (142 aa) initn: 942 init1: 942 opt: 942 Z-score: 1229.8 bits: 233.5 E(85289): 9.3e-62 Smith-Waterman score: 942; 100.0% identity (100.0% similar) in 139 aa overlap (7-145:4-142) 10 20 30 40 50 60 pF1KB5 MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYEN :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPRVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYEN 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 RIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQ 60 70 80 90 100 110 130 140 pF1KB5 ELRRLMMSKENMKLPQPPEGQTYNN ::::::::::::::::::::::::: XP_016 ELRRLMMSKENMKLPQPPEGQTYNN 120 130 140 >>NP_001027459 (OMIM: 602995) ubiquitin-conjugating enzy (147 aa) initn: 920 init1: 881 opt: 886 Z-score: 1156.9 bits: 220.0 E(85289): 1.1e-57 Smith-Waterman score: 886; 89.1% identity (95.2% similar) in 147 aa overlap (1-145:1-147) 10 20 30 40 50 pF1KB5 MAVSTG--VKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNY ::..:: :::::::::::::::::::::::::::::::::::::::::::::::::: : NP_001 MAATTGSGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTIY 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 ENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVV ::::::::.::::::::::: :::::::::::.:.:.:.:: :.: :::::::::::::: NP_001 ENRIYSLKIECGPKYPEAPPFVRFVTKINMNGVNSSNGVVDPRAISVLAKWQNSYSIKVV 70 80 90 100 110 120 120 130 140 pF1KB5 LQELRRLMMSKENMKLPQPPEGQTYNN ::::::::::::::::::::::: :.: NP_001 LQELRRLMMSKENMKLPQPPEGQCYSN 130 140 >>NP_001244322 (OMIM: 602995) ubiquitin-conjugating enzy (170 aa) initn: 906 init1: 881 opt: 881 Z-score: 1149.5 bits: 218.9 E(85289): 2.7e-57 Smith-Waterman score: 881; 91.4% identity (96.4% similar) in 140 aa overlap (6-145:31-170) 10 20 30 pF1KB5 MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGL :::::::::::::::::::::::::::::: NP_001 MPGEVQASYLKSQSKLSDEGRLEPRKFHCKGVKVPRNFRLLEELEEGQKGVGDGTVSWGL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 EDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSS ::::::::::::::::::::: :::::::::.::::::::::: :::::::::::.:.:. NP_001 EDDEDMTLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNGVNSSN 70 80 90 100 110 120 100 110 120 130 140 pF1KB5 GMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN :.:: :.: ::::::::::::::::::::::::::::::::::::: :.: NP_001 GVVDPRAISVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQCYSN 130 140 150 160 170 >>NP_954595 (OMIM: 602995) ubiquitin-conjugating enzyme (170 aa) initn: 906 init1: 881 opt: 881 Z-score: 1149.5 bits: 218.9 E(85289): 2.7e-57 Smith-Waterman score: 881; 91.4% identity (96.4% similar) in 140 aa overlap (6-145:31-170) 10 20 30 pF1KB5 MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGL :::::::::::::::::::::::::::::: NP_954 MPGEVQASYLKSQSKLSDEGRLEPRKFHCKGVKVPRNFRLLEELEEGQKGVGDGTVSWGL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 EDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSS ::::::::::::::::::::: :::::::::.::::::::::: :::::::::::.:.:. NP_954 EDDEDMTLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNGVNSSN 70 80 90 100 110 120 100 110 120 130 140 pF1KB5 GMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN :.:: :.: ::::::::::::::::::::::::::::::::::::: :.: NP_954 GVVDPRAISVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQCYSN 130 140 150 160 170 >>NP_068823 (OMIM: 602995) ubiquitin-conjugating enzyme (170 aa) initn: 906 init1: 881 opt: 881 Z-score: 1149.5 bits: 218.9 E(85289): 2.7e-57 Smith-Waterman score: 881; 91.4% identity (96.4% similar) in 140 aa overlap (6-145:31-170) 10 20 30 pF1KB5 MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGL :::::::::::::::::::::::::::::: NP_068 MPGEVQASYLKSQSKLSDEGRLEPRKFHCKGVKVPRNFRLLEELEEGQKGVGDGTVSWGL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 EDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSS ::::::::::::::::::::: :::::::::.::::::::::: :::::::::::.:.:. NP_068 EDDEDMTLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNGVNSSN 70 80 90 100 110 120 100 110 120 130 140 pF1KB5 GMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN :.:: :.: ::::::::::::::::::::::::::::::::::::: :.: NP_068 GVVDPRAISVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQCYSN 130 140 150 160 170 >>NP_001244324 (OMIM: 602995) ubiquitin-conjugating enzy (144 aa) initn: 900 init1: 862 opt: 877 Z-score: 1145.3 bits: 217.9 E(85289): 4.7e-57 Smith-Waterman score: 877; 89.0% identity (95.9% similar) in 145 aa overlap (1-145:1-144) 10 20 30 40 50 60 pF1KB5 MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYEN ::..:: .:::::::::::::::::::::::::::::::::::::::::::::::: ::: NP_001 MAATTG-SVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTIYEN 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 RIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQ ::::::.::::::::::: :::::::::::.:.:.:.:: :.: :::::::::::::::: NP_001 RIYSLKIECGPKYPEAPPFVRFVTKINMNGVNSSNGVVDPRAISVLAKWQNSYSIKVVLQ 60 70 80 90 100 110 130 140 pF1KB5 ELRRLMMSKENMKLPQPPEGQTYNN ::::::::::::::::::::: :.: NP_001 ELRRLMMSKENMKLPQPPEGQCYSN 120 130 140 >>XP_005251357 (OMIM: 603001) PREDICTED: ubiquitin-conju (105 aa) initn: 711 init1: 711 opt: 711 Z-score: 931.9 bits: 177.9 E(85289): 3.6e-45 Smith-Waterman score: 711; 100.0% identity (100.0% similar) in 105 aa overlap (41-145:1-105) 20 30 40 50 60 70 pF1KB5 RNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECG :::::::::::::::::::::::::::::: XP_005 MTLTRWTGMIIGPPRTNYENRIYSLKVECG 10 20 30 80 90 100 110 120 130 pF1KB5 PKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKE 40 50 60 70 80 90 140 pF1KB5 NMKLPQPPEGQTYNN ::::::::::::::: XP_005 NMKLPQPPEGQTYNN 100 >>NP_001244327 (OMIM: 602995) ubiquitin-conjugating enzy (105 aa) initn: 667 init1: 642 opt: 642 Z-score: 842.3 bits: 161.3 E(85289): 3.5e-40 Smith-Waterman score: 642; 88.6% identity (95.2% similar) in 105 aa overlap (41-145:1-105) 20 30 40 50 60 70 pF1KB5 RNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECG :::::::::::::::: :::::::::.::: NP_001 MTLTRWTGMIIGPPRTIYENRIYSLKIECG 10 20 30 80 90 100 110 120 130 pF1KB5 PKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKE :::::::: :::::::::::.:.:.:.:: :.: :::::::::::::::::::::::::: NP_001 PKYPEAPPFVRFVTKINMNGVNSSNGVVDPRAISVLAKWQNSYSIKVVLQELRRLMMSKE 40 50 60 70 80 90 140 pF1KB5 NMKLPQPPEGQTYNN ::::::::::: :.: NP_001 NMKLPQPPEGQCYSN 100 145 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 06:28:56 2016 done: Sat Nov 5 06:28:57 2016 Total Scan time: 4.440 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]