FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5224, 241 aa 1>>>pF1KB5224 241 - 241 aa - 241 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5877+/-0.000351; mu= 13.1085+/- 0.022 mean_var=74.9465+/-14.876, 0's: 0 Z-trim(115.4): 18 B-trim: 522 in 1/50 Lambda= 0.148149 statistics sampled from 25742 (25759) to 25742 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.684), E-opt: 0.2 (0.302), width: 16 Scan time: 6.810 The best scores are: opt bits E(85289) NP_932070 (OMIM: 601997) BH3-interacting domain de ( 241) 1601 351.2 9.3e-97 NP_001187 (OMIM: 601997) BH3-interacting domain de ( 195) 1271 280.6 1.3e-75 NP_001231496 (OMIM: 601997) BH3-interacting domain ( 195) 1271 280.6 1.3e-75 XP_016884395 (OMIM: 601997) PREDICTED: BH3-interac ( 246) 1248 275.8 4.9e-74 NP_001231501 (OMIM: 601997) BH3-interacting domain ( 99) 623 142.0 3.7e-34 NP_001231498 (OMIM: 601997) BH3-interacting domain ( 99) 623 142.0 3.7e-34 NP_932071 (OMIM: 601997) BH3-interacting domain de ( 99) 623 142.0 3.7e-34 NP_001231499 (OMIM: 601997) BH3-interacting domain ( 99) 623 142.0 3.7e-34 >>NP_932070 (OMIM: 601997) BH3-interacting domain death (241 aa) initn: 1601 init1: 1601 opt: 1601 Z-score: 1858.1 bits: 351.2 E(85289): 9.3e-97 Smith-Waterman score: 1601; 100.0% identity (100.0% similar) in 241 aa overlap (1-241:1-241) 10 20 30 40 50 60 pF1KB5 MCSGAGVMMARWAARGRAGWRSTVRILSPLGHCEPGVSRSCRAAQAMDCEVNNGSSLRDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_932 MCSGAGVMMARWAARGRAGWRSTVRILSPLGHCEPGVSRSCRAAQAMDCEVNNGSSLRDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_932 CITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 DSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_932 DSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_932 LQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNGM 190 200 210 220 230 240 pF1KB5 D : NP_932 D >>NP_001187 (OMIM: 601997) BH3-interacting domain death (195 aa) initn: 1271 init1: 1271 opt: 1271 Z-score: 1478.3 bits: 280.6 E(85289): 1.3e-75 Smith-Waterman score: 1271; 100.0% identity (100.0% similar) in 195 aa overlap (47-241:1-195) 20 30 40 50 60 70 pF1KB5 RAGWRSTVRILSPLGHCEPGVSRSCRAAQAMDCEVNNGSSLRDECITNLLVFGFLQSCSD :::::::::::::::::::::::::::::: NP_001 MDCEVNNGSSLRDECITNLLVFGFLQSCSD 10 20 30 80 90 100 110 120 130 pF1KB5 NSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHL 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB5 AQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLV 100 110 120 130 140 150 200 210 220 230 240 pF1KB5 LALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNGMD ::::::::::::::::::::::::::::::::::::::::::::: NP_001 LALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNGMD 160 170 180 190 >>NP_001231496 (OMIM: 601997) BH3-interacting domain dea (195 aa) initn: 1271 init1: 1271 opt: 1271 Z-score: 1478.3 bits: 280.6 E(85289): 1.3e-75 Smith-Waterman score: 1271; 100.0% identity (100.0% similar) in 195 aa overlap (47-241:1-195) 20 30 40 50 60 70 pF1KB5 RAGWRSTVRILSPLGHCEPGVSRSCRAAQAMDCEVNNGSSLRDECITNLLVFGFLQSCSD :::::::::::::::::::::::::::::: NP_001 MDCEVNNGSSLRDECITNLLVFGFLQSCSD 10 20 30 80 90 100 110 120 130 pF1KB5 NSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHL 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB5 AQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLV 100 110 120 130 140 150 200 210 220 230 240 pF1KB5 LALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNGMD ::::::::::::::::::::::::::::::::::::::::::::: NP_001 LALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNGMD 160 170 180 190 >>XP_016884395 (OMIM: 601997) PREDICTED: BH3-interacting (246 aa) initn: 1248 init1: 1248 opt: 1248 Z-score: 1450.2 bits: 275.8 E(85289): 4.9e-74 Smith-Waterman score: 1248; 100.0% identity (100.0% similar) in 192 aa overlap (47-238:1-192) 20 30 40 50 60 70 pF1KB5 RAGWRSTVRILSPLGHCEPGVSRSCRAAQAMDCEVNNGSSLRDECITNLLVFGFLQSCSD :::::::::::::::::::::::::::::: XP_016 MDCEVNNGSSLRDECITNLLVFGFLQSCSD 10 20 30 80 90 100 110 120 130 pF1KB5 NSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHL 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB5 AQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLV 100 110 120 130 140 150 200 210 220 230 240 pF1KB5 LALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNGMD :::::::::::::::::::::::::::::::::::::::::: XP_016 LALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNVRTLEVSSFPACRPCPFL 160 170 180 190 200 210 XP_016 WKVEKPSGAPASDASTRVTGCPARVWFCCCELESCV 220 230 240 >>NP_001231501 (OMIM: 601997) BH3-interacting domain dea (99 aa) initn: 623 init1: 623 opt: 623 Z-score: 734.2 bits: 142.0 E(85289): 3.7e-34 Smith-Waterman score: 623; 100.0% identity (100.0% similar) in 99 aa overlap (143-241:1-99) 120 130 140 150 160 170 pF1KB5 SRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRD :::::::::::::::::::::::::::::: NP_001 MDRSIPPGLVNGLALQLRNTSRSEEDRNRD 10 20 30 180 190 200 210 220 230 pF1KB5 LATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYV 40 50 60 70 80 90 240 pF1KB5 RSLARNGMD ::::::::: NP_001 RSLARNGMD >>NP_001231498 (OMIM: 601997) BH3-interacting domain dea (99 aa) initn: 623 init1: 623 opt: 623 Z-score: 734.2 bits: 142.0 E(85289): 3.7e-34 Smith-Waterman score: 623; 100.0% identity (100.0% similar) in 99 aa overlap (143-241:1-99) 120 130 140 150 160 170 pF1KB5 SRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRD :::::::::::::::::::::::::::::: NP_001 MDRSIPPGLVNGLALQLRNTSRSEEDRNRD 10 20 30 180 190 200 210 220 230 pF1KB5 LATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYV 40 50 60 70 80 90 240 pF1KB5 RSLARNGMD ::::::::: NP_001 RSLARNGMD >>NP_932071 (OMIM: 601997) BH3-interacting domain death (99 aa) initn: 623 init1: 623 opt: 623 Z-score: 734.2 bits: 142.0 E(85289): 3.7e-34 Smith-Waterman score: 623; 100.0% identity (100.0% similar) in 99 aa overlap (143-241:1-99) 120 130 140 150 160 170 pF1KB5 SRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRD :::::::::::::::::::::::::::::: NP_932 MDRSIPPGLVNGLALQLRNTSRSEEDRNRD 10 20 30 180 190 200 210 220 230 pF1KB5 LATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_932 LATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYV 40 50 60 70 80 90 240 pF1KB5 RSLARNGMD ::::::::: NP_932 RSLARNGMD >>NP_001231499 (OMIM: 601997) BH3-interacting domain dea (99 aa) initn: 623 init1: 623 opt: 623 Z-score: 734.2 bits: 142.0 E(85289): 3.7e-34 Smith-Waterman score: 623; 100.0% identity (100.0% similar) in 99 aa overlap (143-241:1-99) 120 130 140 150 160 170 pF1KB5 SRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRD :::::::::::::::::::::::::::::: NP_001 MDRSIPPGLVNGLALQLRNTSRSEEDRNRD 10 20 30 180 190 200 210 220 230 pF1KB5 LATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYV 40 50 60 70 80 90 240 pF1KB5 RSLARNGMD ::::::::: NP_001 RSLARNGMD 241 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 16:22:15 2016 done: Thu Nov 3 16:22:15 2016 Total Scan time: 6.810 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]