FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5242, 522 aa 1>>>pF1KB5242 522 - 522 aa - 522 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.9699+/-0.000264; mu= 12.1593+/- 0.017 mean_var=118.0237+/-23.551, 0's: 0 Z-trim(123.1): 14 B-trim: 75 in 1/55 Lambda= 0.118056 statistics sampled from 42441 (42457) to 42441 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.796), E-opt: 0.2 (0.498), width: 16 Scan time: 12.750 The best scores are: opt bits E(85289) NP_001245390 (OMIM: 606965) fas-activated serine/t ( 522) 3612 625.6 1.1e-178 XP_016867193 (OMIM: 606965) PREDICTED: fas-activat ( 488) 3352 581.3 2.2e-165 XP_011514065 (OMIM: 606965) PREDICTED: fas-activat ( 381) 2417 422.0 1.6e-117 NP_148936 (OMIM: 606965) fas-activated serine/thre ( 408) 2193 383.8 5.1e-106 XP_005249989 (OMIM: 606965) PREDICTED: fas-activat ( 515) 2193 383.9 6.2e-106 XP_005249990 (OMIM: 606965) PREDICTED: fas-activat ( 515) 2193 383.9 6.2e-106 NP_006703 (OMIM: 606965) fas-activated serine/thre ( 549) 2193 383.9 6.6e-106 XP_016867195 (OMIM: 606965) PREDICTED: fas-activat ( 310) 2105 368.8 1.3e-101 XP_016867194 (OMIM: 606965) PREDICTED: fas-activat ( 353) 1681 296.6 8.1e-80 XP_011514063 (OMIM: 606965) PREDICTED: fas-activat ( 494) 1681 296.7 1.1e-79 XP_011514064 (OMIM: 606965) PREDICTED: fas-activat ( 462) 1447 256.8 1e-67 >>NP_001245390 (OMIM: 606965) fas-activated serine/threo (522 aa) initn: 3612 init1: 3612 opt: 3612 Z-score: 3328.9 bits: 625.6 E(85289): 1.1e-178 Smith-Waterman score: 3612; 100.0% identity (100.0% similar) in 522 aa overlap (1-522:1-522) 10 20 30 40 50 60 pF1KB5 MRRPRGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQTSPARLSGLLLIPPVQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRRPRGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQTSPARLSGLLLIPPVQP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CCLGPSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CCLGPSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LGQLLGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGQLLGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCAL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 EQERRLRLPPKPPPPLQPLLREARPEELTPHVMVLLAQHLARHRLREPQLLEAIAHFLVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQERRLRLPPKPPPPLQPLLREARPEELTPHVMVLLAQHLARHRLREPQLLEAIAHFLVV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 QETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNILMSLCQLRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNILMSLCQLRC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 LPFRALHFVFSPGFINYISGTPHALIVRRYLSLLDTAVELELPGYRGPRLPRRQQVPIFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPFRALHFVFSPGFINYISGTPHALIVRRYLSLLDTAVELELPGYRGPRLPRRQQVPIFP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 QPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSSGAVLPVRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSSGAVLPVRT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 QDPFLPYPPRSCPQGQAASSATTRDPAQRVVLVLRERWHFCRDGRVLLGSRALRERHLGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QDPFLPYPPRSCPQGQAASSATTRDPAQRVVLVLRERWHFCRDGRVLLGSRALRERHLGL 430 440 450 460 470 480 490 500 510 520 pF1KB5 MGYQLLPLPFEELESQRGLPQLKSYLRQKLQALGLRWGPEGG :::::::::::::::::::::::::::::::::::::::::: NP_001 MGYQLLPLPFEELESQRGLPQLKSYLRQKLQALGLRWGPEGG 490 500 510 520 >>XP_016867193 (OMIM: 606965) PREDICTED: fas-activated s (488 aa) initn: 3352 init1: 3352 opt: 3352 Z-score: 3090.0 bits: 581.3 E(85289): 2.2e-165 Smith-Waterman score: 3352; 100.0% identity (100.0% similar) in 488 aa overlap (35-522:1-488) 10 20 30 40 50 60 pF1KB5 RGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQTSPARLSGLLLIPPVQPCCLG :::::::::::::::::::::::::::::: XP_016 MLRVLLSAQTSPARLSGLLLIPPVQPCCLG 10 20 30 70 80 90 100 110 120 pF1KB5 PSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQL 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB5 LGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCALEQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCALEQER 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB5 RLRLPPKPPPPLQPLLREARPEELTPHVMVLLAQHLARHRLREPQLLEAIAHFLVVQETQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLRLPPKPPPPLQPLLREARPEELTPHVMVLLAQHLARHRLREPQLLEAIAHFLVVQETQ 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB5 LSSKVVQKLVLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNILMSLCQLRCLPFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSSKVVQKLVLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNILMSLCQLRCLPFR 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB5 ALHFVFSPGFINYISGTPHALIVRRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALHFVFSPGFINYISGTPHALIVRRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLI 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB5 TDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSSGAVLPVRTQDPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSSGAVLPVRTQDPF 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB5 LPYPPRSCPQGQAASSATTRDPAQRVVLVLRERWHFCRDGRVLLGSRALRERHLGLMGYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPYPPRSCPQGQAASSATTRDPAQRVVLVLRERWHFCRDGRVLLGSRALRERHLGLMGYQ 400 410 420 430 440 450 490 500 510 520 pF1KB5 LLPLPFEELESQRGLPQLKSYLRQKLQALGLRWGPEGG :::::::::::::::::::::::::::::::::::::: XP_016 LLPLPFEELESQRGLPQLKSYLRQKLQALGLRWGPEGG 460 470 480 >>XP_011514065 (OMIM: 606965) PREDICTED: fas-activated s (381 aa) initn: 2446 init1: 2417 opt: 2417 Z-score: 2230.9 bits: 422.0 E(85289): 1.6e-117 Smith-Waterman score: 2417; 100.0% identity (100.0% similar) in 353 aa overlap (170-522:29-381) 140 150 160 170 180 190 pF1KB5 QDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCALEQERRLRLPPKPPPPLQPL :::::::::::::::::::::::::::::: XP_011 MRRPRGEPGPRAPRPTEGATCAGPGESCFPSDGPLVCALEQERRLRLPPKPPPPLQPL 10 20 30 40 50 200 210 220 230 240 250 pF1KB5 LREARPEELTPHVMVLLAQHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LREARPEELTPHVMVLLAQHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGR 60 70 80 90 100 110 260 270 280 290 300 310 pF1KB5 LNYLPLEQQFMPCLERILAREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNYLPLEQQFMPCLERILAREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYIS 120 130 140 150 160 170 320 330 340 350 360 370 pF1KB5 GTPHALIVRRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTPHALIVRRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVA 180 190 200 210 220 230 380 390 400 410 420 430 pF1KB5 EGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAAS 240 250 260 270 280 290 440 450 460 470 480 490 pF1KB5 SATTRDPAQRVVLVLRERWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SATTRDPAQRVVLVLRERWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGL 300 310 320 330 340 350 500 510 520 pF1KB5 PQLKSYLRQKLQALGLRWGPEGG ::::::::::::::::::::::: XP_011 PQLKSYLRQKLQALGLRWGPEGG 360 370 380 >>NP_148936 (OMIM: 606965) fas-activated serine/threonin (408 aa) initn: 2413 init1: 2183 opt: 2193 Z-score: 2024.3 bits: 383.8 E(85289): 5.1e-106 Smith-Waterman score: 2353; 92.9% identity (92.9% similar) in 380 aa overlap (170-522:29-408) 140 150 160 170 180 190 pF1KB5 QDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCALEQERRLRLPPKPPPPLQPL :::::::::::::::::::::::::::::: NP_148 MRRPRGEPGPRAPRPTEGATCAGPGESCFPSDGPLVCALEQERRLRLPPKPPPPLQPL 10 20 30 40 50 200 210 220 230 pF1KB5 LR---------------------------EARPEELTPHVMVLLAQHLARHRLREPQLLE :: ::::::::::::::::::::::::::::::: NP_148 LRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVMVLLAQHLARHRLREPQLLE 60 70 80 90 100 110 240 250 260 270 280 290 pF1KB5 AIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 AIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNIL 120 130 140 150 160 170 300 310 320 330 340 350 pF1KB5 MSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSLLDTAVELELPGYRGPRLPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 MSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSLLDTAVELELPGYRGPRLPR 180 190 200 210 220 230 360 370 380 390 400 410 pF1KB5 RQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 RQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSS 240 250 260 270 280 290 420 430 440 450 460 470 pF1KB5 GAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLVLRERWHFCRDGRVLLGSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 GAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLVLRERWHFCRDGRVLLGSRA 300 310 320 330 340 350 480 490 500 510 520 pF1KB5 LRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQALGLRWGPEGG :::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 LRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQALGLRWGPEGG 360 370 380 390 400 >>XP_005249989 (OMIM: 606965) PREDICTED: fas-activated s (515 aa) initn: 2183 init1: 2183 opt: 2193 Z-score: 2022.8 bits: 383.9 E(85289): 6.2e-106 Smith-Waterman score: 3288; 94.8% identity (94.8% similar) in 515 aa overlap (35-522:1-515) 10 20 30 40 50 60 pF1KB5 RGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQTSPARLSGLLLIPPVQPCCLG :::::::::::::::::::::::::::::: XP_005 MLRVLLSAQTSPARLSGLLLIPPVQPCCLG 10 20 30 70 80 90 100 110 120 pF1KB5 PSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQL 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB5 LGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCALEQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCALEQER 100 110 120 130 140 150 190 200 210 pF1KB5 RLRLPPKPPPPLQPLLR---------------------------EARPEELTPHVMVLLA ::::::::::::::::: :::::::::::::::: XP_005 RLRLPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVMVLLA 160 170 180 190 200 210 220 230 240 250 260 270 pF1KB5 QHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCLERIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCLERIL 220 230 240 250 260 270 280 290 300 310 320 330 pF1KB5 AREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSLLDTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSLLDTA 280 290 300 310 320 330 340 350 360 370 380 390 pF1KB5 VELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTV 340 350 360 370 380 390 400 410 420 430 440 450 pF1KB5 PPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLVLRER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLVLRER 400 410 420 430 440 450 460 470 480 490 500 510 pF1KB5 WHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQALGLRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQALGLRW 460 470 480 490 500 510 520 pF1KB5 GPEGG ::::: XP_005 GPEGG >>XP_005249990 (OMIM: 606965) PREDICTED: fas-activated s (515 aa) initn: 2183 init1: 2183 opt: 2193 Z-score: 2022.8 bits: 383.9 E(85289): 6.2e-106 Smith-Waterman score: 3288; 94.8% identity (94.8% similar) in 515 aa overlap (35-522:1-515) 10 20 30 40 50 60 pF1KB5 RGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQTSPARLSGLLLIPPVQPCCLG :::::::::::::::::::::::::::::: XP_005 MLRVLLSAQTSPARLSGLLLIPPVQPCCLG 10 20 30 70 80 90 100 110 120 pF1KB5 PSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQL 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB5 LGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCALEQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCALEQER 100 110 120 130 140 150 190 200 210 pF1KB5 RLRLPPKPPPPLQPLLR---------------------------EARPEELTPHVMVLLA ::::::::::::::::: :::::::::::::::: XP_005 RLRLPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVMVLLA 160 170 180 190 200 210 220 230 240 250 260 270 pF1KB5 QHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCLERIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCLERIL 220 230 240 250 260 270 280 290 300 310 320 330 pF1KB5 AREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSLLDTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSLLDTA 280 290 300 310 320 330 340 350 360 370 380 390 pF1KB5 VELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTV 340 350 360 370 380 390 400 410 420 430 440 450 pF1KB5 PPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLVLRER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLVLRER 400 410 420 430 440 450 460 470 480 490 500 510 pF1KB5 WHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQALGLRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQALGLRW 460 470 480 490 500 510 520 pF1KB5 GPEGG ::::: XP_005 GPEGG >>NP_006703 (OMIM: 606965) fas-activated serine/threonin (549 aa) initn: 2183 init1: 2183 opt: 2193 Z-score: 2022.4 bits: 383.9 E(85289): 6.6e-106 Smith-Waterman score: 3548; 95.1% identity (95.1% similar) in 549 aa overlap (1-522:1-549) 10 20 30 40 50 60 pF1KB5 MRRPRGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQTSPARLSGLLLIPPVQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MRRPRGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQTSPARLSGLLLIPPVQP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CCLGPSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 CCLGPSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LGQLLGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LGQLLGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCAL 130 140 150 160 170 180 190 200 210 pF1KB5 EQERRLRLPPKPPPPLQPLLR---------------------------EARPEELTPHVM ::::::::::::::::::::: :::::::::::: NP_006 EQERRLRLPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVM 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB5 VLLAQHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VLLAQHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCL 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB5 ERILAREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ERILAREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSL 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB5 LDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQ 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB5 DLTVPPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DLTVPPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLV 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB5 LRERWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LRERWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQAL 490 500 510 520 530 540 520 pF1KB5 GLRWGPEGG ::::::::: NP_006 GLRWGPEGG >>XP_016867195 (OMIM: 606965) PREDICTED: fas-activated s (310 aa) initn: 2105 init1: 2105 opt: 2105 Z-score: 1945.1 bits: 368.8 E(85289): 1.3e-101 Smith-Waterman score: 2105; 100.0% identity (100.0% similar) in 310 aa overlap (213-522:1-310) 190 200 210 220 230 240 pF1KB5 ERRLRLPPKPPPPLQPLLREARPEELTPHVMVLLAQHLARHRLREPQLLEAIAHFLVVQE :::::::::::::::::::::::::::::: XP_016 MVLLAQHLARHRLREPQLLEAIAHFLVVQE 10 20 30 250 260 270 280 290 300 pF1KB5 TQLSSKVVQKLVLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNILMSLCQLRCLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TQLSSKVVQKLVLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNILMSLCQLRCLP 40 50 60 70 80 90 310 320 330 340 350 360 pF1KB5 FRALHFVFSPGFINYISGTPHALIVRRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRALHFVFSPGFINYISGTPHALIVRRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQP 100 110 120 130 140 150 370 380 390 400 410 420 pF1KB5 LITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSSGAVLPVRTQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSSGAVLPVRTQD 160 170 180 190 200 210 430 440 450 460 470 480 pF1KB5 PFLPYPPRSCPQGQAASSATTRDPAQRVVLVLRERWHFCRDGRVLLGSRALRERHLGLMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFLPYPPRSCPQGQAASSATTRDPAQRVVLVLRERWHFCRDGRVLLGSRALRERHLGLMG 220 230 240 250 260 270 490 500 510 520 pF1KB5 YQLLPLPFEELESQRGLPQLKSYLRQKLQALGLRWGPEGG :::::::::::::::::::::::::::::::::::::::: XP_016 YQLLPLPFEELESQRGLPQLKSYLRQKLQALGLRWGPEGG 280 290 300 310 >>XP_016867194 (OMIM: 606965) PREDICTED: fas-activated s (353 aa) initn: 1901 init1: 1671 opt: 1681 Z-score: 1553.9 bits: 296.6 E(85289): 8.1e-80 Smith-Waterman score: 1841; 91.2% identity (91.2% similar) in 306 aa overlap (170-448:29-334) 140 150 160 170 180 190 pF1KB5 QDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCALEQERRLRLPPKPPPPLQPL :::::::::::::::::::::::::::::: XP_016 MRRPRGEPGPRAPRPTEGATCAGPGESCFPSDGPLVCALEQERRLRLPPKPPPPLQPL 10 20 30 40 50 200 210 220 230 pF1KB5 LR---------------------------EARPEELTPHVMVLLAQHLARHRLREPQLLE :: ::::::::::::::::::::::::::::::: XP_016 LRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVMVLLAQHLARHRLREPQLLE 60 70 80 90 100 110 240 250 260 270 280 290 pF1KB5 AIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNIL 120 130 140 150 160 170 300 310 320 330 340 350 pF1KB5 MSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSLLDTAVELELPGYRGPRLPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSLLDTAVELELPGYRGPRLPR 180 190 200 210 220 230 360 370 380 390 400 410 pF1KB5 RQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSS 240 250 260 270 280 290 420 430 440 450 460 470 pF1KB5 GAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLVLRERWHFCRDGRVLLGSRA :::::::::::::::::::::::::::::::::::: XP_016 GAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQSYPSRNWSPREACPSSRAT 300 310 320 330 340 350 480 490 500 510 520 pF1KB5 LRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQALGLRWGPEGG >>XP_011514063 (OMIM: 606965) PREDICTED: fas-activated s (494 aa) initn: 1671 init1: 1671 opt: 1681 Z-score: 1551.8 bits: 296.7 E(85289): 1.1e-79 Smith-Waterman score: 3036; 94.3% identity (94.3% similar) in 475 aa overlap (1-448:1-475) 10 20 30 40 50 60 pF1KB5 MRRPRGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQTSPARLSGLLLIPPVQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRRPRGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQTSPARLSGLLLIPPVQP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CCLGPSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CCLGPSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LGQLLGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGQLLGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCAL 130 140 150 160 170 180 190 200 210 pF1KB5 EQERRLRLPPKPPPPLQPLLR---------------------------EARPEELTPHVM ::::::::::::::::::::: :::::::::::: XP_011 EQERRLRLPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVM 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB5 VLLAQHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLLAQHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCL 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB5 ERILAREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERILAREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSL 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB5 LDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQ 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB5 DLTVPPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLV ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLTVPPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQSYPSR 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB5 LRERWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQAL XP_011 NWSPREACPSSRAT 490 522 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 16:25:20 2016 done: Thu Nov 3 16:25:22 2016 Total Scan time: 12.750 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]