FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5266, 350 aa 1>>>pF1KB5266 350 - 350 aa - 350 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.7057+/-0.000511; mu= 8.9299+/- 0.031 mean_var=144.1687+/-31.013, 0's: 0 Z-trim(113.0): 247 B-trim: 1679 in 2/51 Lambda= 0.106817 statistics sampled from 21777 (22166) to 21777 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.636), E-opt: 0.2 (0.26), width: 16 Scan time: 7.010 The best scores are: opt bits E(85289) NP_009109 (OMIM: 605986) serine-threonine kinase r ( 350) 2352 374.7 1.7e-103 XP_005253351 (OMIM: 605986) PREDICTED: serine-thre ( 256) 1706 275.0 1.2e-73 NP_001155052 (OMIM: 614783,614813) POC1 centriolar ( 359) 342 65.0 3e-10 NP_056241 (OMIM: 614783,614813) POC1 centriolar pr ( 407) 342 65.0 3.3e-10 NP_758440 (OMIM: 614784,615973) POC1 centriolar pr ( 478) 341 64.9 4.1e-10 XP_016861593 (OMIM: 614783,614813) PREDICTED: POC1 ( 321) 337 64.1 4.7e-10 NP_001155053 (OMIM: 614783,614813) POC1 centriolar ( 369) 337 64.2 5.2e-10 XP_011531864 (OMIM: 614783,614813) PREDICTED: POC1 ( 300) 327 62.6 1.3e-09 XP_011531863 (OMIM: 614783,614813) PREDICTED: POC1 ( 326) 327 62.6 1.4e-09 XP_011531862 (OMIM: 614783,614813) PREDICTED: POC1 ( 374) 327 62.7 1.5e-09 NP_001186706 (OMIM: 614784,615973) POC1 centriolar ( 436) 324 62.3 2.3e-09 NP_008882 (OMIM: 601787) transcription initiation ( 800) 314 61.0 1.1e-08 XP_016860389 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 299 58.3 2.7e-08 XP_011510137 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 299 58.3 2.7e-08 XP_016860391 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 299 58.3 2.7e-08 XP_016860390 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 299 58.3 2.7e-08 XP_016860387 (OMIM: 612173) PREDICTED: sperm-assoc ( 390) 299 58.4 3.1e-08 XP_016860386 (OMIM: 612173) PREDICTED: sperm-assoc ( 512) 299 58.5 3.8e-08 XP_016860385 (OMIM: 612173) PREDICTED: sperm-assoc ( 512) 299 58.5 3.8e-08 XP_011510124 (OMIM: 612173) PREDICTED: sperm-assoc ( 528) 299 58.5 3.9e-08 XP_011510125 (OMIM: 612173) PREDICTED: sperm-assoc ( 528) 299 58.5 3.9e-08 XP_011510123 (OMIM: 612173) PREDICTED: sperm-assoc ( 537) 299 58.5 3.9e-08 XP_011510121 (OMIM: 612173) PREDICTED: sperm-assoc ( 577) 299 58.5 4.1e-08 XP_011510116 (OMIM: 612173) PREDICTED: sperm-assoc ( 600) 299 58.5 4.3e-08 NP_078808 (OMIM: 612173) sperm-associated antigen ( 631) 299 58.6 4.4e-08 NP_942593 (OMIM: 610767,611081) autophagy-related ( 444) 246 50.3 9.9e-06 XP_005246143 (OMIM: 610767,611081) PREDICTED: auto ( 463) 246 50.3 1e-05 XP_005246141 (OMIM: 610767,611081) PREDICTED: auto ( 480) 246 50.3 1e-05 NP_001177196 (OMIM: 610767,611081) autophagy-relat ( 491) 246 50.3 1.1e-05 NP_001177195 (OMIM: 610767,611081) autophagy-relat ( 523) 246 50.3 1.1e-05 XP_006712671 (OMIM: 610767,611081) PREDICTED: auto ( 540) 246 50.3 1.1e-05 NP_060444 (OMIM: 610767,611081) autophagy-related ( 588) 246 50.4 1.2e-05 NP_110430 (OMIM: 610767,611081) autophagy-related ( 607) 246 50.4 1.2e-05 XP_005246139 (OMIM: 610767,611081) PREDICTED: auto ( 624) 246 50.4 1.3e-05 XP_016879716 (OMIM: 609804) PREDICTED: cilia- and ( 531) 243 49.9 1.5e-05 NP_001074025 (OMIM: 609804) cilia- and flagella-as ( 552) 243 49.9 1.6e-05 NP_659491 (OMIM: 609804) cilia- and flagella-assoc ( 620) 243 49.9 1.7e-05 XP_011510118 (OMIM: 612173) PREDICTED: sperm-assoc ( 592) 240 49.4 2.3e-05 XP_011510120 (OMIM: 612173) PREDICTED: sperm-assoc ( 577) 237 49.0 3.1e-05 XP_011510119 (OMIM: 612173) PREDICTED: sperm-assoc ( 582) 237 49.0 3.1e-05 XP_011510117 (OMIM: 612173) PREDICTED: sperm-assoc ( 592) 237 49.0 3.2e-05 XP_016878352 (OMIM: 602703,616212) PREDICTED: kata ( 655) 233 48.4 5.2e-05 NP_005877 (OMIM: 602703,616212) katanin p80 WD40 r ( 655) 233 48.4 5.2e-05 XP_016878353 (OMIM: 602703,616212) PREDICTED: kata ( 655) 233 48.4 5.2e-05 XP_006721186 (OMIM: 602703,616212) PREDICTED: kata ( 658) 233 48.4 5.2e-05 XP_005255829 (OMIM: 602703,616212) PREDICTED: kata ( 672) 233 48.4 5.3e-05 XP_016878351 (OMIM: 602703,616212) PREDICTED: kata ( 672) 233 48.4 5.3e-05 XP_016878350 (OMIM: 602703,616212) PREDICTED: kata ( 672) 233 48.4 5.3e-05 XP_006721184 (OMIM: 602703,616212) PREDICTED: kata ( 675) 233 48.4 5.3e-05 XP_006721185 (OMIM: 602703,616212) PREDICTED: kata ( 675) 233 48.4 5.3e-05 >>NP_009109 (OMIM: 605986) serine-threonine kinase recep (350 aa) initn: 2352 init1: 2352 opt: 2352 Z-score: 1979.2 bits: 374.7 E(85289): 1.7e-103 Smith-Waterman score: 2352; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:1-350) 10 20 30 40 50 60 pF1KB5 MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 AVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 DKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 DKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 NFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 NFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 GGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTY 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 GLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA :::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 GLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA 310 320 330 340 350 >>XP_005253351 (OMIM: 605986) PREDICTED: serine-threonin (256 aa) initn: 1706 init1: 1706 opt: 1706 Z-score: 1442.9 bits: 275.0 E(85289): 1.2e-73 Smith-Waterman score: 1706; 100.0% identity (100.0% similar) in 256 aa overlap (95-350:1-256) 70 80 90 100 110 120 pF1KB5 ATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQDKLL :::::::::::::::::::::::::::::: XP_005 MTLAHKHIVKTVDFTQDSNYLLTGGQDKLL 10 20 30 130 140 150 160 170 180 pF1KB5 RIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSLNFNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSLNFNM 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB5 SVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVAGGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVAGGED 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB5 FKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWK 160 170 180 190 200 210 310 320 330 340 350 pF1KB5 CVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA :::::::::::::::::::::::::::::::::::::::::::::: XP_005 CVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA 220 230 240 250 >>NP_001155052 (OMIM: 614783,614813) POC1 centriolar pro (359 aa) initn: 317 init1: 127 opt: 342 Z-score: 305.0 bits: 65.0 E(85289): 3e-10 Smith-Waterman score: 342; 26.4% identity (57.3% similar) in 288 aa overlap (12-294:17-300) 10 20 30 40 50 pF1KB5 MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTF :: :. . :: : : :. :. :. . . : NP_001 MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQ---LASGSMDSCLMVWHMKPQSRAYRF 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 LGHKGAVWGATLNKDATKAATAAADFTAKVW-DAVSGDELMTLAHKHIVKTVDFTQDSNY ::: :: .... .. :... : :...: :.:. . :: :..: : .:.. NP_001 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 LLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSA-DDKTVRLWDHAT ..:...:: .... .. . . .: : . .. : . . . :.:: :::::.:::... NP_001 FVTASDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 MTEVKSLNFNMS-VSSMEYIPEGE-ILVITYGRSIAFHSAVSLDPIKSFEA-PATINSAS :.: . . :. ... : : : . . .. .. . .. .. :..:. : NP_001 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 LHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLR .:: ..:.... : : : :. : . .:: :: : :: :: .:::. : . NP_001 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVM 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 LWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA .:.. NP_001 VWKSNFDIVDHGEVTKVPRPPATLASSMGNLTVSILEQRLTLTEDKLKQCLENQQLIMQR 300 310 320 330 340 350 >>NP_056241 (OMIM: 614783,614813) POC1 centriolar protei (407 aa) initn: 317 init1: 127 opt: 342 Z-score: 304.3 bits: 65.0 E(85289): 3.3e-10 Smith-Waterman score: 342; 26.4% identity (57.3% similar) in 288 aa overlap (12-294:17-300) 10 20 30 40 50 pF1KB5 MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTF :: :. . :: : : :. :. :. . . : NP_056 MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQ---LASGSMDSCLMVWHMKPQSRAYRF 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 LGHKGAVWGATLNKDATKAATAAADFTAKVW-DAVSGDELMTLAHKHIVKTVDFTQDSNY ::: :: .... .. :... : :...: :.:. . :: :..: : .:.. NP_056 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 LLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSA-DDKTVRLWDHAT ..:...:: .... .. . . .: : . .. : . . . :.:: :::::.:::... NP_056 FVTASDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 MTEVKSLNFNMS-VSSMEYIPEGE-ILVITYGRSIAFHSAVSLDPIKSFEA-PATINSAS :.: . . :. ... : : : . . .. .. . .. .. :..:. : NP_056 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 LHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLR .:: ..:.... : : : :. : . .:: :: : :: :: .:::. : . NP_056 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVM 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 LWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA .:.. NP_056 VWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSVESVQSQPQEPVSVP 300 310 320 330 340 350 >>NP_758440 (OMIM: 614784,615973) POC1 centriolar protei (478 aa) initn: 382 init1: 161 opt: 341 Z-score: 302.6 bits: 64.9 E(85289): 4.1e-10 Smith-Waterman score: 341; 25.9% identity (57.6% similar) in 290 aa overlap (12-294:16-299) 10 20 30 40 50 pF1KB5 MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFL :: ...: .: : : : .: : :: . .. NP_758 MASATEDPVLERYFKGHKAAITSLDLS---PNGKQLATASWDTFLMLWNFKPHARAYRYV 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 GHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYL ::: .: .. .. .. :.:. : :...: . .. . :: :..:::. :...: NP_758 GHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 LTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILS-ADDKTVRLWDHATM :...:: ...... . . . :: .. : . . . :.: ..:::...:: .. NP_758 ATASEDKSIKVWSMYR-QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK 120 130 140 150 160 170 180 190 200 210 220 pF1KB5 TEVKSLNFNMSVSSMEYI---PEGEILVITYGRSIAFHSAVSLDPI-KSFEAPAT-INSA :. ::. ::. ... : : .. . . . . : .. . . ... . .: NP_758 QCVN--NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCI 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB5 SLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTL :.:: ..:.... : : : :. . . .:: ::. : :: :::.:::. : . NP_758 SFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB5 RLWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVK ::.: NP_758 LLWRTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINPKLEVIDL 300 310 320 330 340 350 >>XP_016861593 (OMIM: 614783,614813) PREDICTED: POC1 cen (321 aa) initn: 264 init1: 127 opt: 337 Z-score: 301.5 bits: 64.1 E(85289): 4.7e-10 Smith-Waterman score: 337; 26.9% identity (60.4% similar) in 245 aa overlap (55-294:19-262) 30 40 50 60 70 80 pF1KB5 ITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAK : ::: :: .... .. :... : :.. XP_016 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVR 10 20 30 40 90 100 110 120 130 140 pF1KB5 VW-DAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHT .: :.:. . :: :..: : .:.. ..:...:: .... .. . . .: : XP_016 IWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFS-LSQHI 50 60 70 80 90 100 150 160 170 180 190 200 pF1KB5 SGIKKALWCSEDKQILSA-DDKTVRLWDHATMTEVKSLNFNMS-VSSMEYIPEGE-ILVI . .. : . . . :.:: :::::.:::... :.: . . :. ... : : : . XP_016 NWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAA 110 120 130 140 150 160 210 220 230 240 250 pF1KB5 TYGRSIAFHSAVSLDPIKSFEA-PATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELE . .. .. . .. .. :..:. :.:: ..:.... : : : :. : XP_016 GMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB5 SYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPK . .:: :: : :: :: .:::. : . .:.. XP_016 TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMG 230 240 250 260 270 280 320 330 340 350 pF1KB5 IGFPETTEEELEEIASENSDCIFPSAPDVKA XP_016 NLTVSILEQRLTLTEDKLKQCLENQQLIMQRATP 290 300 310 320 >>NP_001155053 (OMIM: 614783,614813) POC1 centriolar pro (369 aa) initn: 264 init1: 127 opt: 337 Z-score: 300.7 bits: 64.2 E(85289): 5.2e-10 Smith-Waterman score: 337; 26.9% identity (60.4% similar) in 245 aa overlap (55-294:19-262) 30 40 50 60 70 80 pF1KB5 ITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAK : ::: :: .... .. :... : :.. NP_001 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVR 10 20 30 40 90 100 110 120 130 140 pF1KB5 VW-DAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHT .: :.:. . :: :..: : .:.. ..:...:: .... .. . . .: : NP_001 IWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFS-LSQHI 50 60 70 80 90 100 150 160 170 180 190 200 pF1KB5 SGIKKALWCSEDKQILSA-DDKTVRLWDHATMTEVKSLNFNMS-VSSMEYIPEGE-ILVI . .. : . . . :.:: :::::.:::... :.: . . :. ... : : : . NP_001 NWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAA 110 120 130 140 150 160 210 220 230 240 250 pF1KB5 TYGRSIAFHSAVSLDPIKSFEA-PATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELE . .. .. . .. .. :..:. :.:: ..:.... : : : :. : NP_001 GMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB5 SYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPK . .:: :: : :: :: .:::. : . .:.. NP_001 TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMG 230 240 250 260 270 280 320 330 340 350 pF1KB5 IGFPETTEEELEEIASENSDCIFPSAPDVKA NP_001 NLPEVDFPVPPGRGRSVESVQSQPQEPVSVPQTLTSTLEHIVGQLDVLTQTVSILEQRLT 290 300 310 320 330 340 >>XP_011531864 (OMIM: 614783,614813) PREDICTED: POC1 cen (300 aa) initn: 317 init1: 127 opt: 327 Z-score: 293.6 bits: 62.6 E(85289): 1.3e-09 Smith-Waterman score: 327; 26.8% identity (57.1% similar) in 280 aa overlap (12-286:17-292) 10 20 30 40 50 pF1KB5 MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTF :: :. . :: : : :. :. :. . . : XP_011 MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQ---LASGSMDSCLMVWHMKPQSRAYRF 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 LGHKGAVWGATLNKDATKAATAAADFTAKVW-DAVSGDELMTLAHKHIVKTVDFTQDSNY ::: :: .... .. :... : :...: :.:. . :: :..: : .:.. XP_011 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 LLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSA-DDKTVRLWDHAT ..:...:: .... .. . . .: : . .. : . . . :.:: :::::.:::... XP_011 FVTASDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 MTEVKSLNFNMS-VSSMEYIPEGE-ILVITYGRSIAFHSAVSLDPIKSFEA-PATINSAS :.: . . :. ... : : : . . .. .. . .. .. :..:. : XP_011 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 LHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLR .:: ..:.... : : : :. : . .:: :: : :: :: .:::. : XP_011 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVI 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 LWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA XP_011 CARP 300 >>XP_011531863 (OMIM: 614783,614813) PREDICTED: POC1 cen (326 aa) initn: 317 init1: 127 opt: 327 Z-score: 293.1 bits: 62.6 E(85289): 1.4e-09 Smith-Waterman score: 327; 26.8% identity (57.1% similar) in 280 aa overlap (12-286:17-292) 10 20 30 40 50 pF1KB5 MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTF :: :. . :: : : :. :. :. . . : XP_011 MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQ---LASGSMDSCLMVWHMKPQSRAYRF 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 LGHKGAVWGATLNKDATKAATAAADFTAKVW-DAVSGDELMTLAHKHIVKTVDFTQDSNY ::: :: .... .. :... : :...: :.:. . :: :..: : .:.. XP_011 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 LLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSA-DDKTVRLWDHAT ..:...:: .... .. . . .: : . .. : . . . :.:: :::::.:::... XP_011 FVTASDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 MTEVKSLNFNMS-VSSMEYIPEGE-ILVITYGRSIAFHSAVSLDPIKSFEA-PATINSAS :.: . . :. ... : : : . . .. .. . .. .. :..:. : XP_011 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 LHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLR .:: ..:.... : : : :. : . .:: :: : :: :: .:::. : XP_011 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQTV 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 LWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA XP_011 SILEQRLTLTEDKLKQCLENQQLIMQRATP 300 310 320 >>XP_011531862 (OMIM: 614783,614813) PREDICTED: POC1 cen (374 aa) initn: 317 init1: 127 opt: 327 Z-score: 292.3 bits: 62.7 E(85289): 1.5e-09 Smith-Waterman score: 327; 26.8% identity (57.1% similar) in 280 aa overlap (12-286:17-292) 10 20 30 40 50 pF1KB5 MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTF :: :. . :: : : :. :. :. . . : XP_011 MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQ---LASGSMDSCLMVWHMKPQSRAYRF 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 LGHKGAVWGATLNKDATKAATAAADFTAKVW-DAVSGDELMTLAHKHIVKTVDFTQDSNY ::: :: .... .. :... : :...: :.:. . :: :..: : .:.. XP_011 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 LLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSA-DDKTVRLWDHAT ..:...:: .... .. . . .: : . .. : . . . :.:: :::::.:::... XP_011 FVTASDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 MTEVKSLNFNMS-VSSMEYIPEGE-ILVITYGRSIAFHSAVSLDPIKSFEA-PATINSAS :.: . . :. ... : : : . . .. .. . .. .. :..:. : XP_011 RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 LHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLR .:: ..:.... : : : :. : . .:: :: : :: :: .:::. : XP_011 FHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQPE 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 LWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA XP_011 VDFPVPPGRGRSVESVQSQPQEPVSVPQTLTSTLEHIVGQLDVLTQTVSILEQRLTLTED 300 310 320 330 340 350 350 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 22:25:23 2016 done: Thu Nov 3 22:25:25 2016 Total Scan time: 7.010 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]