FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5278, 375 aa 1>>>pF1KB5278 375 - 375 aa - 375 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2401+/-0.000409; mu= 16.2078+/- 0.025 mean_var=57.4141+/-11.855, 0's: 0 Z-trim(110.7): 178 B-trim: 321 in 1/50 Lambda= 0.169264 statistics sampled from 18868 (19090) to 18868 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.594), E-opt: 0.2 (0.224), width: 16 Scan time: 7.720 The best scores are: opt bits E(85289) XP_016857602 (OMIM: 606494) PREDICTED: CMP-N-acety ( 375) 2495 617.8 1.2e-176 NP_006270 (OMIM: 606494) CMP-N-acetylneuraminate-b ( 375) 2495 617.8 1.2e-176 XP_006710888 (OMIM: 606494) PREDICTED: CMP-N-acety ( 434) 2316 574.1 2e-163 NP_777624 (OMIM: 606494) CMP-N-acetylneuraminate-b ( 390) 2228 552.6 5.5e-157 NP_777629 (OMIM: 606494) CMP-N-acetylneuraminate-b ( 359) 2136 530.1 2.9e-150 XP_011540279 (OMIM: 606494) PREDICTED: CMP-N-acety ( 449) 2049 508.9 8.9e-144 NP_777631 (OMIM: 606494) CMP-N-acetylneuraminate-b ( 413) 2043 507.5 2.3e-143 NP_777628 (OMIM: 606494) CMP-N-acetylneuraminate-b ( 429) 2043 507.5 2.4e-143 NP_777623 (OMIM: 606494) CMP-N-acetylneuraminate-b ( 444) 2043 507.5 2.4e-143 XP_006710890 (OMIM: 606494) PREDICTED: CMP-N-acety ( 418) 1957 486.5 4.9e-137 XP_011540282 (OMIM: 606494) PREDICTED: CMP-N-acety ( 379) 1865 464.0 2.6e-130 XP_016857600 (OMIM: 606494) PREDICTED: CMP-N-acety ( 392) 1864 463.7 3.1e-130 XP_016857601 (OMIM: 606494) PREDICTED: CMP-N-acety ( 392) 1864 463.7 3.1e-130 XP_011540278 (OMIM: 606494) PREDICTED: CMP-N-acety ( 472) 1864 463.8 3.7e-130 XP_011540276 (OMIM: 606494) PREDICTED: CMP-N-acety ( 488) 1864 463.8 3.8e-130 XP_011540275 (OMIM: 606494) PREDICTED: CMP-N-acety ( 502) 1864 463.8 3.9e-130 XP_016857598 (OMIM: 606494) PREDICTED: CMP-N-acety ( 503) 1864 463.8 3.9e-130 XP_016857608 (OMIM: 606494) PREDICTED: CMP-N-acety ( 282) 1841 458.1 1.2e-128 NP_001257389 (OMIM: 606494) CMP-N-acetylneuraminat ( 344) 1834 456.4 4.5e-128 XP_016857610 (OMIM: 606494) PREDICTED: CMP-N-acety ( 268) 1790 445.6 6.2e-125 XP_016857609 (OMIM: 606494) PREDICTED: CMP-N-acety ( 268) 1790 445.6 6.2e-125 XP_011540285 (OMIM: 606494) PREDICTED: CMP-N-acety ( 340) 1702 424.2 2.2e-118 XP_016857605 (OMIM: 606494) PREDICTED: CMP-N-acety ( 340) 1702 424.2 2.2e-118 XP_006710891 (OMIM: 606494) PREDICTED: CMP-N-acety ( 341) 1662 414.4 2e-115 XP_016857603 (OMIM: 606494) PREDICTED: CMP-N-acety ( 341) 1662 414.4 2e-115 XP_016857604 (OMIM: 606494) PREDICTED: CMP-N-acety ( 341) 1662 414.4 2e-115 NP_777626 (OMIM: 606494) CMP-N-acetylneuraminate-b ( 277) 1658 413.4 3.2e-115 NP_001257388 (OMIM: 606494) CMP-N-acetylneuraminat ( 345) 1658 413.4 3.9e-115 XP_011540290 (OMIM: 606494) PREDICTED: CMP-N-acety ( 327) 1611 401.9 1.1e-111 XP_011540289 (OMIM: 606494) PREDICTED: CMP-N-acety ( 327) 1611 401.9 1.1e-111 XP_016857607 (OMIM: 606494) PREDICTED: CMP-N-acety ( 292) 1391 348.2 1.4e-95 NP_001257390 (OMIM: 606494) CMP-N-acetylneuraminat ( 261) 1299 325.7 7.5e-89 XP_016857606 (OMIM: 606494) PREDICTED: CMP-N-acety ( 331) 1206 303.0 6.4e-82 XP_011540283 (OMIM: 606494) PREDICTED: CMP-N-acety ( 346) 1206 303.0 6.6e-82 XP_011540288 (OMIM: 606494) PREDICTED: CMP-N-acety ( 331) 1204 302.5 8.9e-82 XP_011540286 (OMIM: 606494) PREDICTED: CMP-N-acety ( 331) 1204 302.5 8.9e-82 XP_011540287 (OMIM: 606494) PREDICTED: CMP-N-acety ( 331) 1204 302.5 8.9e-82 XP_016857599 (OMIM: 606494) PREDICTED: CMP-N-acety ( 456) 1205 302.8 1e-81 NP_001257394 (OMIM: 606494) CMP-N-acetylneuraminat ( 185) 1121 282.2 6.7e-76 NP_001257392 (OMIM: 606494) CMP-N-acetylneuraminat ( 201) 1117 281.2 1.4e-75 NP_001257391 (OMIM: 606494) CMP-N-acetylneuraminat ( 230) 997 251.9 1.1e-66 XP_016857611 (OMIM: 606494) PREDICTED: CMP-N-acety ( 221) 911 230.9 2.2e-60 NP_777627 (OMIM: 606494) CMP-N-acetylneuraminate-b ( 155) 887 225.0 9.1e-59 NP_001257393 (OMIM: 606494) CMP-N-acetylneuraminat ( 186) 870 220.9 1.9e-57 XP_016860689 (OMIM: 604402,609056) PREDICTED: lact ( 390) 789 201.2 3.3e-51 XP_016860690 (OMIM: 604402,609056) PREDICTED: lact ( 390) 789 201.2 3.3e-51 XP_016860688 (OMIM: 604402,609056) PREDICTED: lact ( 390) 789 201.2 3.3e-51 NP_001035902 (OMIM: 604402,609056) lactosylceramid ( 395) 789 201.2 3.3e-51 NP_003887 (OMIM: 604402,609056) lactosylceramide a ( 418) 789 201.2 3.5e-51 XP_016860701 (OMIM: 604402,609056) PREDICTED: lact ( 290) 753 192.4 1.1e-48 >>XP_016857602 (OMIM: 606494) PREDICTED: CMP-N-acetylneu (375 aa) initn: 2495 init1: 2495 opt: 2495 Z-score: 3292.1 bits: 617.8 E(85289): 1.2e-176 Smith-Waterman score: 2495; 100.0% identity (100.0% similar) in 375 aa overlap (1-375:1-375) 10 20 30 40 50 60 pF1KB5 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSNSVVLSFDSAGQTLGSEYDRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSNSVVLSFDSAGQTLGSEYDRL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 REFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 YDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 YIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 TLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLR 310 320 330 340 350 360 370 pF1KB5 KLVKARVITDLSSGI ::::::::::::::: XP_016 KLVKARVITDLSSGI 370 >>NP_006270 (OMIM: 606494) CMP-N-acetylneuraminate-beta- (375 aa) initn: 2495 init1: 2495 opt: 2495 Z-score: 3292.1 bits: 617.8 E(85289): 1.2e-176 Smith-Waterman score: 2495; 100.0% identity (100.0% similar) in 375 aa overlap (1-375:1-375) 10 20 30 40 50 60 pF1KB5 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSNSVVLSFDSAGQTLGSEYDRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSNSVVLSFDSAGQTLGSEYDRL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 REFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 REFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 YDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 YDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 YIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 YIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 TLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 TLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLR 310 320 330 340 350 360 370 pF1KB5 KLVKARVITDLSSGI ::::::::::::::: NP_006 KLVKARVITDLSSGI 370 >>XP_006710888 (OMIM: 606494) PREDICTED: CMP-N-acetylneu (434 aa) initn: 2316 init1: 2316 opt: 2316 Z-score: 3054.8 bits: 574.1 E(85289): 2e-163 Smith-Waterman score: 2316; 99.1% identity (99.1% similar) in 350 aa overlap (1-350:1-350) 10 20 30 40 50 60 pF1KB5 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSNSVVLSFDSAGQTLGSEYDRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSNSVVLSFDSAGQTLGSEYDRL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 REFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 REFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 YDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 YIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 TLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLR :::::::::::::::::::::::::::::::::::::::::::::: : XP_006 TLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKEPRPHVENLNPSELR 310 320 330 340 350 360 370 pF1KB5 KLVKARVITDLSSGI XP_006 LPHFCFDHQPSTDPSLKPGNLGPVLQQLLCCYIWVMGGCWREPPICADSCFFLDAQYPAR 370 380 390 400 410 420 >>NP_777624 (OMIM: 606494) CMP-N-acetylneuraminate-beta- (390 aa) initn: 2228 init1: 2228 opt: 2228 Z-score: 2939.4 bits: 552.6 E(85289): 5.5e-157 Smith-Waterman score: 2450; 95.9% identity (96.2% similar) in 390 aa overlap (1-375:1-390) 10 20 30 40 pF1KB5 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDS---------------NSVVLS ::::::::::::::::::::::::::::::::::::::: .::::: NP_777 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSSKYSHSSSPQEKPVADSVVLS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 FDSAGQTLGSEYDRLGFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 FDSAGQTLGSEYDRLGFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKP 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB5 APMFLDDSFRKWARIREFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 APMFLDDSFRKWARIREFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGN 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB5 GGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 GGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB5 FVLAGFKWQDFKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 FVLAGFKWQDFKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLI 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB5 GLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 GLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIK 310 320 330 340 350 360 350 360 370 pF1KB5 ESWTHNIQREKEFLRKLVKARVITDLSSGI :::::::::::::::::::::::::::::: NP_777 ESWTHNIQREKEFLRKLVKARVITDLSSGI 370 380 390 >>NP_777629 (OMIM: 606494) CMP-N-acetylneuraminate-beta- (359 aa) initn: 2136 init1: 2136 opt: 2136 Z-score: 2818.6 bits: 530.1 E(85289): 2.9e-150 Smith-Waterman score: 2352; 95.5% identity (95.7% similar) in 375 aa overlap (1-375:1-359) 10 20 30 40 50 60 pF1KB5 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSNSVVLSFDSAGQTLGSEYDRL ::::::::::::::::::::::::::::::::::::::: .:::: NP_777 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDS----------------KYDRL 10 20 30 40 70 80 90 100 110 120 pF1KB5 GFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 GFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARI 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB5 REFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 REFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDD 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB5 YDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 YDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLK 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB5 YIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 YIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIP 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB5 TLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 TLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLR 290 300 310 320 330 340 370 pF1KB5 KLVKARVITDLSSGI ::::::::::::::: NP_777 KLVKARVITDLSSGI 350 >>XP_011540279 (OMIM: 606494) PREDICTED: CMP-N-acetylneu (449 aa) initn: 2049 init1: 2049 opt: 2049 Z-score: 2702.2 bits: 508.9 E(85289): 8.9e-144 Smith-Waterman score: 2271; 94.8% identity (95.1% similar) in 365 aa overlap (1-350:1-365) 10 20 30 40 pF1KB5 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDS---------------NSVVLS ::::::::::::::::::::::::::::::::::::::: .::::: XP_011 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSSKYSHSSSPQEKPVADSVVLS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 FDSAGQTLGSEYDRLGFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FDSAGQTLGSEYDRLGFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKP 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB5 APMFLDDSFRKWARIREFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APMFLDDSFRKWARIREFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGN 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB5 GGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB5 FVLAGFKWQDFKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FVLAGFKWQDFKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLI 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB5 GLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIK 310 320 330 340 350 360 350 360 370 pF1KB5 ESWTHNIQREKEFLRKLVKARVITDLSSGI : : XP_011 EPRPHVENLNPSELRLPHFCFDHQPSTDPSLKPGNLGPVLQQLLCCYIWVMGGCWREPPI 370 380 390 400 410 420 >>NP_777631 (OMIM: 606494) CMP-N-acetylneuraminate-beta- (413 aa) initn: 2293 init1: 2040 opt: 2043 Z-score: 2694.9 bits: 507.5 E(85289): 2.3e-143 Smith-Waterman score: 2196; 83.2% identity (83.5% similar) in 423 aa overlap (7-375:7-413) 10 20 30 40 50 60 pF1KB5 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSNSVVLSFDSAGQTLGSEYDRL ::::::::::::::::::::::::::::::::: .:::: NP_777 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDS----------------KYDRL 10 20 30 40 70 pF1KB5 GFLLNLDSKL-------------------------------------------------- :::::::::: NP_777 GFLLNLDSKLSPRTLCTVVFGLDCILESPGEPKKLLMPASHPLEILKSLSEDTAFALGFL 50 60 70 80 90 100 80 90 100 110 120 pF1KB5 ----PAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARIREFVPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 KLPRPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARIREFVPP 110 120 130 140 150 160 130 140 150 160 170 180 pF1KB5 FGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 FGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVR 170 180 190 200 210 220 190 200 210 220 230 240 pF1KB5 LNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 LNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKE 230 240 250 260 270 280 250 260 270 280 290 300 pF1KB5 RVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 RVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVA 290 300 310 320 330 340 310 320 330 340 350 360 pF1KB5 VTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 VTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKAR 350 360 370 380 390 400 370 pF1KB5 VITDLSSGI ::::::::: NP_777 VITDLSSGI 410 >>NP_777628 (OMIM: 606494) CMP-N-acetylneuraminate-beta- (429 aa) initn: 2481 init1: 2040 opt: 2043 Z-score: 2694.6 bits: 507.5 E(85289): 2.4e-143 Smith-Waterman score: 2238; 86.7% identity (86.7% similar) in 407 aa overlap (23-375:23-429) 10 20 30 40 50 60 pF1KB5 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSNSVVLSFDSAGQTLGSEYDRL :::::::::::::::::::::::::::::::::::::: NP_777 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSNSVVLSFDSAGQTLGSEYDRL 10 20 30 40 50 60 70 pF1KB5 GFLLNLDSKL-------------------------------------------------- :::::::::: NP_777 GFLLNLDSKLSPRTLCTVVFGLDCILESPGEPKKLLMPASHPLEILKSLSEDTAFALGFL 70 80 90 100 110 120 80 90 100 110 120 pF1KB5 ----PAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARIREFVPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 KLPRPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARIREFVPP 130 140 150 160 170 180 130 140 150 160 170 180 pF1KB5 FGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 FGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVR 190 200 210 220 230 240 190 200 210 220 230 240 pF1KB5 LNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 LNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKE 250 260 270 280 290 300 250 260 270 280 290 300 pF1KB5 RVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 RVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVA 310 320 330 340 350 360 310 320 330 340 350 360 pF1KB5 VTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 VTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKAR 370 380 390 400 410 420 370 pF1KB5 VITDLSSGI ::::::::: NP_777 VITDLSSGI >>NP_777623 (OMIM: 606494) CMP-N-acetylneuraminate-beta- (444 aa) initn: 2290 init1: 2040 opt: 2043 Z-score: 2694.4 bits: 507.5 E(85289): 2.4e-143 Smith-Waterman score: 2110; 85.7% identity (86.2% similar) in 391 aa overlap (39-375:54-444) 10 20 30 40 50 60 pF1KB5 NLLLALCLFLVLGFLYYSAWKLHLLQWEEDSNSVVLSFDSAGQTLGSEYDRLGFLLNLDS ..:::::::::::::::::::::::::::: NP_777 YYSAWKLHLLQWEEDSSKYSHSSSPQEKPVADSVVLSFDSAGQTLGSEYDRLGFLLNLDS 30 40 50 60 70 80 70 pF1KB5 KL------------------------------------------------------PAEL :: :::: NP_777 KLSPRTLCTVVFGLDCILESPGEPKKLLMPASHPLEILKSLSEDTAFALGFLKLPRPAEL 90 100 110 120 130 140 80 90 100 110 120 130 pF1KB5 ATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARIREFVPPFGIKGQDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 ATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARIREFVPPFGIKGQDN 150 160 170 180 190 200 140 150 160 170 180 190 pF1KB5 LIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 LIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKG 210 220 230 240 250 260 200 210 220 230 240 250 pF1KB5 FEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 FEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGF 270 280 290 300 310 320 260 270 280 290 300 310 pF1KB5 WKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 WKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGC 330 340 350 360 370 380 320 330 340 350 360 370 pF1KB5 DEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVITDLSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_777 DEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVITDLSSG 390 400 410 420 430 440 pF1KB5 I : NP_777 I >-- initn: 266 init1: 264 opt: 264 Z-score: 346.5 bits: 73.0 E(85289): 1.5e-12 Smith-Waterman score: 264; 97.5% identity (100.0% similar) in 40 aa overlap (1-40:1-40) 10 20 30 40 50 60 pF1KB5 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSNSVVLSFDSAGQTLGSEYDRL :::::::::::::::::::::::::::::::::::::::. NP_777 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSSKYSHSSSPQEKPVADSVVLS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARI NP_777 FDSAGQTLGSEYDRLGFLLNLDSKLSPRTLCTVVFGLDCILESPGEPKKLLMPASHPLEI 70 80 90 100 110 120 >>XP_006710890 (OMIM: 606494) PREDICTED: CMP-N-acetylneu (418 aa) initn: 1957 init1: 1957 opt: 1957 Z-score: 2581.3 bits: 486.5 E(85289): 4.9e-137 Smith-Waterman score: 2173; 94.3% identity (94.6% similar) in 350 aa overlap (1-350:1-334) 10 20 30 40 50 60 pF1KB5 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSNSVVLSFDSAGQTLGSEYDRL ::::::::::::::::::::::::::::::::::::::: .:::: XP_006 MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDS----------------KYDRL 10 20 30 40 70 80 90 100 110 120 pF1KB5 GFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARI 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB5 REFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 REFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDD 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB5 YDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLK 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB5 YIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIP 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB5 TLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLR :::::::::::::::::::::::::::::::::::::::::::::: : XP_006 TLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKEPRPHVENLNPSELR 290 300 310 320 330 340 370 pF1KB5 KLVKARVITDLSSGI XP_006 LPHFCFDHQPSTDPSLKPGNLGPVLQQLLCCYIWVMGGCWREPPICADSCFFLDAQYPAR 350 360 370 380 390 400 375 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 12:23:31 2016 done: Sat Nov 5 12:23:33 2016 Total Scan time: 7.720 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]