Result of FASTA (omim) for
pF1KB5307
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5307, 412 aa
1>>>pF1KB5307 412 - 412 aa - 412 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9923+/-0.000403; mu= 19.0439+/- 0.025
mean_var=69.7236+/-14.198, 0's: 0 Z-trim(112.8): 32 B-trim: 403 in 1/50
Lambda= 0.153598
statistics sampled from 21851 (21880) to 21851 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.633), E-opt: 0.2 (0.257), width: 16
Scan time: 8.620
The best scores are: opt bits E(85289)
NP_005872 (OMIM: 614901,614923) [3-methyl-2-oxobut ( 412) 2751 618.9 7.2e-177
XP_016878348 (OMIM: 614901,614923) PREDICTED: 3-me ( 410) 2443 550.6 2.5e-156
NP_001116429 (OMIM: 614901,614923) [3-methyl-2-oxo ( 365) 2442 550.4 2.7e-156
NP_001258855 (OMIM: 614901,614923) [3-methyl-2-oxo ( 335) 1881 426.0 6.6e-119
XP_011509647 (OMIM: 602524) PREDICTED: pyruvate de ( 360) 289 73.3 1.1e-12
NP_002601 (OMIM: 602524) [Pyruvate dehydrogenase ( ( 436) 289 73.3 1.3e-12
NP_002602 (OMIM: 602525) pyruvate dehydrogenase ki ( 407) 288 73.1 1.4e-12
NP_002603 (OMIM: 602527) pyruvate dehydrogenase ki ( 411) 279 71.1 5.7e-12
NP_005382 (OMIM: 300906) pyruvate dehydrogenase ki ( 406) 245 63.6 1e-09
NP_001135858 (OMIM: 300906) pyruvate dehydrogenase ( 415) 245 63.6 1.1e-09
NP_001186827 (OMIM: 602525) pyruvate dehydrogenase ( 343) 233 60.9 5.8e-09
NP_001186828 (OMIM: 602525) pyruvate dehydrogenase ( 343) 233 60.9 5.8e-09
NP_001186829 (OMIM: 602525) pyruvate dehydrogenase ( 199) 207 54.9 2.1e-07
XP_011509645 (OMIM: 602524) PREDICTED: pyruvate de ( 380) 188 50.9 6.3e-06
XP_011509646 (OMIM: 602524) PREDICTED: pyruvate de ( 380) 188 50.9 6.3e-06
XP_011509649 (OMIM: 602524) PREDICTED: pyruvate de ( 380) 188 50.9 6.3e-06
NP_001265478 (OMIM: 602524) [Pyruvate dehydrogenas ( 456) 188 51.0 7.2e-06
XP_006712658 (OMIM: 602524) PREDICTED: pyruvate de ( 244) 158 44.1 0.00045
>>NP_005872 (OMIM: 614901,614923) [3-methyl-2-oxobutanoa (412 aa)
initn: 2751 init1: 2751 opt: 2751 Z-score: 3296.4 bits: 618.9 E(85289): 7.2e-177
Smith-Waterman score: 2751; 100.0% identity (100.0% similar) in 412 aa overlap (1-412:1-412)
10 20 30 40 50 60
pF1KB5 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAID
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 AAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 TIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQS
310 320 330 340 350 360
370 380 390 400 410
pF1KB5 GPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI
370 380 390 400 410
>>XP_016878348 (OMIM: 614901,614923) PREDICTED: 3-methyl (410 aa)
initn: 2443 init1: 2443 opt: 2443 Z-score: 2927.6 bits: 550.6 E(85289): 2.5e-156
Smith-Waterman score: 2443; 99.7% identity (100.0% similar) in 366 aa overlap (1-366:1-366)
10 20 30 40 50 60
pF1KB5 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAID
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 AAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 TIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQS
310 320 330 340 350 360
370 380 390 400 410
pF1KB5 GPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI
:::::.
XP_016 GPMHGLQPQVRTENQELQDCRTLNIQLAGPRGRPQKPIGSCYITDPALKP
370 380 390 400 410
>>NP_001116429 (OMIM: 614901,614923) [3-methyl-2-oxobuta (365 aa)
initn: 2442 init1: 2442 opt: 2442 Z-score: 2927.1 bits: 550.4 E(85289): 2.7e-156
Smith-Waterman score: 2442; 100.0% identity (100.0% similar) in 365 aa overlap (1-365:1-365)
10 20 30 40 50 60
pF1KB5 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAID
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 AAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 TIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQS
310 320 330 340 350 360
370 380 390 400 410
pF1KB5 GPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI
:::::
NP_001 GPMHG
>>NP_001258855 (OMIM: 614901,614923) [3-methyl-2-oxobuta (335 aa)
initn: 1881 init1: 1881 opt: 1881 Z-score: 2255.7 bits: 426.0 E(85289): 6.6e-119
Smith-Waterman score: 2181; 91.8% identity (91.8% similar) in 365 aa overlap (1-365:1-335)
10 20 30 40 50 60
pF1KB5 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MILASVLRSGPGGGLPLRPLLGPALALRARSTSATDTHHVEMARERSKTVTSFYNQSAID
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 AAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVI
::::::::::::::::::::::::::::::::::::::::::
NP_001 LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMR------------------
250 260 270 280
310 320 330 340 350 360
pF1KB5 TIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQS
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ------------ISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQS
290 300 310 320 330
370 380 390 400 410
pF1KB5 GPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI
:::::
NP_001 GPMHG
>>XP_011509647 (OMIM: 602524) PREDICTED: pyruvate dehydr (360 aa)
initn: 516 init1: 146 opt: 289 Z-score: 348.7 bits: 73.3 E(85289): 1.1e-12
Smith-Waterman score: 552; 32.9% identity (61.2% similar) in 340 aa overlap (93-407:2-322)
70 80 90 100 110 120
pF1KB5 AEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTI
.:.::::::.:. .: . :: . .:..
XP_011 MFLRQELPVRLANIMKEISLLPDNLLRTPSV
10 20 30
130 140 150 160 170
pF1KB5 LHVHELYIRAFQKLTDFPPIKDQ-ADEAQ----YCQLVRQLLDDHKDVVTLLAEGLRESR
:. ::...:.: :: ::. :..:. . . : .. . :.::. .:.:. : .
XP_011 QLVQSWYIQSLQELLDF---KDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYK
40 50 60 70 80
180 190 200 210 220
pF1KB5 KHIEDEKL----VRYFLDKTLTSRLGIRMLATHHLALHEDK----PDF---VGIICTRLS
. . . . :.::::. ::..:::: ..: : : :. .: : .
XP_011 ESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCN
90 100 110 120 130 140
230 240 250 260 270
pF1KB5 PKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFP-------FIPMPLDYILPELLKN
..:. . :::::. : :.:..... .. :. : ..: : ... ::.::
XP_011 VLEVIKDGYENARRLCDLYYINSPELELE-ELNAKSPGQPIQVVYVPSHLYHMVFELFKN
150 160 170 180 190 200
280 290 300 310 320 330
pF1KB5 AMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEAS
::::::: : . : . . .. .. :: ...::::::. . .::...: ..::
XP_011 AMRATMEHHANRGV-YPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPR-
210 220 230 240 250 260
340 350 360 370 380 390
pF1KB5 TQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTD--VY
::. ... :. :::.::: :: ::.:. :.:.: ::.: ::: .:
XP_011 ---PRVET----------SRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIY
270 280 290 300 310
400 410
pF1KB5 LRLRHIDGREESFRI
.. :. :
XP_011 IKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA
320 330 340 350 360
>>NP_002601 (OMIM: 602524) [Pyruvate dehydrogenase (acet (436 aa)
initn: 540 init1: 146 opt: 289 Z-score: 347.6 bits: 73.3 E(85289): 1.3e-12
Smith-Waterman score: 552; 32.9% identity (61.2% similar) in 340 aa overlap (93-407:78-398)
70 80 90 100 110 120
pF1KB5 AEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTI
.:.::::::.:. .: . :: . .:..
NP_002 FYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSV
50 60 70 80 90 100
130 140 150 160 170
pF1KB5 LHVHELYIRAFQKLTDFPPIKDQ-ADEAQ----YCQLVRQLLDDHKDVVTLLAEGLRESR
:. ::...:.: :: ::. :..:. . . : .. . :.::. .:.:. : .
NP_002 QLVQSWYIQSLQELLDF---KDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYK
110 120 130 140 150 160
180 190 200 210 220
pF1KB5 KHIEDEKL----VRYFLDKTLTSRLGIRMLATHHLALHEDK----PDF---VGIICTRLS
. . . . :.::::. ::..:::: ..: : : :. .: : .
NP_002 ESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCN
170 180 190 200 210 220
230 240 250 260 270
pF1KB5 PKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFP-------FIPMPLDYILPELLKN
..:. . :::::. : :.:..... .. :. : ..: : ... ::.::
NP_002 VLEVIKDGYENARRLCDLYYINSPELELE-ELNAKSPGQPIQVVYVPSHLYHMVFELFKN
230 240 250 260 270 280
280 290 300 310 320 330
pF1KB5 AMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEAS
::::::: : . : . . .. .. :: ...::::::. . .::...: ..::
NP_002 AMRATMEHHANRGV-YPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPR-
290 300 310 320 330 340
340 350 360 370 380 390
pF1KB5 TQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTD--VY
::. ... :. :::.::: :: ::.:. :.:.: ::.: ::: .:
NP_002 ---PRVET----------SRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIY
350 360 370 380
400 410
pF1KB5 LRLRHIDGREESFRI
.. :. :
NP_002 IKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA
390 400 410 420 430
>>NP_002602 (OMIM: 602525) pyruvate dehydrogenase kinase (407 aa)
initn: 448 init1: 149 opt: 288 Z-score: 346.8 bits: 73.1 E(85289): 1.4e-12
Smith-Waterman score: 565; 32.8% identity (60.7% similar) in 338 aa overlap (90-407:49-369)
60 70 80 90 100 110
pF1KB5 DAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCN
: .:.::::::.:. .: . :: . .
NP_002 YIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLST
20 30 40 50 60 70
120 130 140 150 160 170
pF1KB5 PTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLL---DDHKDVVTLLAEGLRES
:.. :. :.... . .: :: :. :.. :. . :.::: .:.:. :
NP_002 PSVQLVQSWYVQSLLDIMEFLD-KDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEY
80 90 100 110 120 130
180 190 200 210 220
pF1KB5 RKHIEDEKL----VRYFLDKTLTSRLGIRMLATHHLALHEDK-----PDFVGIICTRLSP
. :. . ..::::. ::..:::: ..: . . . : .: : .
NP_002 KDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNV
140 150 160 170 180 190
230 240 250 260 270 280
pF1KB5 KKIIEKWVDFARRLCEHKYGNAPRVRINGHVAA--RFP----FIPMPLDYILPELLKNAM
..... :.:. ::.. : .: ..:. :: . : ..: : ..: ::.::::
NP_002 SEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAM
200 210 220 230 240 250
290 300 310 320 330 340
pF1KB5 RATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQ
:::.::: .. .: . . .: .. :: :..::::::. . ..:...: ..::
NP_002 RATVESH-ESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTA-----
260 270 280 290 300 310
350 360 370 380 390
pF1KB5 DPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTD--VYLR
: .: :. . :. :::.::: :: ::.:. :.::: :..:.::: .::.
NP_002 -PTPQP---------GTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLK
320 330 340 350 360
400 410
pF1KB5 LRHIDGREESFRI
:. :
NP_002 ALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
370 380 390 400
>>NP_002603 (OMIM: 602527) pyruvate dehydrogenase kinase (411 aa)
initn: 462 init1: 144 opt: 279 Z-score: 335.9 bits: 71.1 E(85289): 5.7e-12
Smith-Waterman score: 534; 31.1% identity (63.4% similar) in 328 aa overlap (93-401:56-365)
70 80 90 100 110 120
pF1KB5 AEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTI
.:.::::::.:. .: . :: . . ..
NP_002 HFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILKEIDILPTQLVNTSSV
30 40 50 60 70 80
130 140 150 160 170
pF1KB5 LHVHELYIRAFQKLTDF---PPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKH
:. ::.... :..: : :: ... . . .. . :..:: .:.:. : .
NP_002 QLVKSWYIQSLMDLVEFHEKSP-DDQKALSDFVDTLIKVRNRHHNVVPTMAQGIIEYKDA
90 100 110 120 130 140
180 190 200 210 220 230
pF1KB5 -----IEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDK----PDFVGIICTRLSPKKI
. ...: .::::. .:.. ::: ..:. . :. :. .: : . .
NP_002 CTVDPVTNQNL-QYFLDRFYMNRISTRMLMNQHILIFSDSQTGNPSHIGSIDPNCDVVAV
150 160 170 180 190 200
240 250 260 270 280
pF1KB5 IEKWVDFARRLCEHKYGNAPRVRINGHVAARFP-------FIPMPLDYILPELLKNAMRA
.. . .: ::.. : ..:..... .: ..:: ..: : ..: ::.::::::
NP_002 VQDAFECSRMLCDQYYLSSPELKLT-QVNGKFPDQPIHIVYVPSHLHHMLFELFKNAMRA
210 220 230 240 250 260
290 300 310 320 330 340
pF1KB5 TMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDP
:.: . . : .: ::.. ... :: :.:::::::. . .::...: ..:: . ..:
NP_002 TVEHQENQPSLTPIEVIVVLGKE-DLTIKISDRGGGVPLRIIDRLFSYTYSTAPTPVMD-
270 280 290 300 310 320
350 360 370 380 390 400
pF1KB5 RISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHI
.....:. :::.::: :: ::.:. :.:.: ::.: :::. . :.
NP_002 -------------NSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLKAL
330 340 350 360
410
pF1KB5 DGREESFRI
NP_002 SSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM
370 380 390 400 410
>>NP_005382 (OMIM: 300906) pyruvate dehydrogenase kinase (406 aa)
initn: 449 init1: 170 opt: 245 Z-score: 295.3 bits: 63.6 E(85289): 1e-09
Smith-Waterman score: 524; 29.2% identity (60.2% similar) in 359 aa overlap (70-410:27-366)
40 50 60 70 80 90
pF1KB5 VEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELP
:. ..: :: :.. : .:..:::
NP_005 MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGR--DNACEKTSYMFLRKELP
10 20 30 40 50
100 110 120 130 140 150
pF1KB5 VRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEA--QYCQLVRQ
::.:. .. :: . :.. :. :...: .: .. . . .. .. :.. .
NP_005 VRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIK
60 70 80 90 100 110
160 170 180 190 200 210
pF1KB5 LLDDHKDVVTLLAEGLRESRKHIEDEKLV----RYFLDKTLTSRLGIRMLATHHLAL---
. . :.::: .:.:. : .... . .. .::::. :.:...::: ..: :
NP_005 VRNRHNDVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGG
120 130 140 150 160 170
220 230 240 250 260
pF1KB5 --HEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFP-----
. .: .: : . ... . :. :::. : ::..... . :. :
NP_005 DTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVE-EFNAKAPDKPIQ
180 190 200 210 220 230
270 280 290 300 310 320
pF1KB5 --FIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIA
..: : ..: ::.::.::::.: . : . : : .. . :: :.::: :::.
NP_005 VVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVP
240 250 260 270 280 290
330 340 350 360 370 380
pF1KB5 HKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLG
. .::...: ..:: . .: ....:. :::.::: :: ::.:.
NP_005 LRKIDRLFNYMYSTAPRPSLEP--------------TRAAPLAGFGYGLPISRLYARYFQ
300 310 320 330
390 400 410
pF1KB5 GSLQLQSLQGIGTDVYLRLRHIDGREESFRI
:.:.: :..:.:::. . :. ... :::
NP_005 GDLKLYSMEGVGTDAVIYLKALSS--ESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPR
340 350 360 370 380 390
>>NP_001135858 (OMIM: 300906) pyruvate dehydrogenase kin (415 aa)
initn: 449 init1: 170 opt: 245 Z-score: 295.2 bits: 63.6 E(85289): 1.1e-09
Smith-Waterman score: 524; 29.2% identity (60.2% similar) in 359 aa overlap (70-410:27-366)
40 50 60 70 80 90
pF1KB5 VEMARERSKTVTSFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELP
:. ..: :: :.. : .:..:::
NP_001 MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGR--DNACEKTSYMFLRKELP
10 20 30 40 50
100 110 120 130 140 150
pF1KB5 VRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEA--QYCQLVRQ
::.:. .. :: . :.. :. :...: .: .. . . .. .. :.. .
NP_001 VRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIK
60 70 80 90 100 110
160 170 180 190 200 210
pF1KB5 LLDDHKDVVTLLAEGLRESRKHIEDEKLV----RYFLDKTLTSRLGIRMLATHHLAL---
. . :.::: .:.:. : .... . .. .::::. :.:...::: ..: :
NP_001 VRNRHNDVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGG
120 130 140 150 160 170
220 230 240 250 260
pF1KB5 --HEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFP-----
. .: .: : . ... . :. :::. : ::..... . :. :
NP_001 DTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVE-EFNAKAPDKPIQ
180 190 200 210 220 230
270 280 290 300 310 320
pF1KB5 --FIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIA
..: : ..: ::.::.::::.: . : . : : .. . :: :.::: :::.
NP_001 VVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVP
240 250 260 270 280 290
330 340 350 360 370 380
pF1KB5 HKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLG
. .::...: ..:: . .: ....:. :::.::: :: ::.:.
NP_001 LRKIDRLFNYMYSTAPRPSLEP--------------TRAAPLAGFGYGLPISRLYARYFQ
300 310 320 330
390 400 410
pF1KB5 GSLQLQSLQGIGTDVYLRLRHIDGREESFRI
:.:.: :..:.:::. . :. ... :::
NP_001 GDLKLYSMEGVGTDAVIYLKALSS--ESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPR
340 350 360 370 380 390
412 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 12:27:41 2016 done: Sat Nov 5 12:27:42 2016
Total Scan time: 8.620 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]