FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5317, 392 aa 1>>>pF1KB5317 392 - 392 aa - 392 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.5086+/-0.000401; mu= 2.2318+/- 0.025 mean_var=181.3386+/-36.205, 0's: 0 Z-trim(118.1): 7 B-trim: 287 in 1/52 Lambda= 0.095242 statistics sampled from 30784 (30791) to 30784 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.361), width: 16 Scan time: 9.820 The best scores are: opt bits E(85289) NP_005094 (OMIM: 604825) fasciculation and elongat ( 392) 2551 362.8 8.2e-100 XP_005271792 (OMIM: 604825) PREDICTED: fasciculati ( 392) 2551 362.8 8.2e-100 XP_005271791 (OMIM: 604825) PREDICTED: fasciculati ( 392) 2551 362.8 8.2e-100 NP_001036013 (OMIM: 604826) fasciculation and elon ( 380) 917 138.2 3.1e-32 XP_006712216 (OMIM: 604826) PREDICTED: fasciculati ( 279) 808 123.2 7.8e-28 NP_072043 (OMIM: 604825) fasciculation and elongat ( 104) 695 107.4 1.6e-23 NP_005093 (OMIM: 604826) fasciculation and elongat ( 353) 499 80.8 5.7e-15 >>NP_005094 (OMIM: 604825) fasciculation and elongation (392 aa) initn: 2551 init1: 2551 opt: 2551 Z-score: 1912.9 bits: 362.8 E(85289): 8.2e-100 Smith-Waterman score: 2551; 100.0% identity (100.0% similar) in 392 aa overlap (1-392:1-392) 10 20 30 40 50 60 pF1KB5 MEAPLVSLDEEFEDLRPSCSEDPEEKPQCFYGSSPHHLEDPSLSELENFSSEIISFKSME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MEAPLVSLDEEFEDLRPSCSEDPEEKPQCFYGSSPHHLEDPSLSELENFSSEIISFKSME 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEETLQDEEVWDALTDNYIPSLSED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEETLQDEEVWDALTDNYIPSLSED 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 WRDPNIEALNGNCSDTEIHEKEEEEFNEKSENDSGINEEPLLTADQVIEEIEEMMQNSPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 WRDPNIEALNGNCSDTEIHEKEEEEFNEKSENDSGINEEPLLTADQVIEEIEEMMQNSPD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 PEEEEEVLEEEDGGETSSQADSVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDQVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PEEEEEVLEEEDGGETSSQADSVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDQVE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GAIRDFSEELVQQLARRDELEFEKEVKNSFITVLIEVQNKQKEQRELMKKRRKEKGLSLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GAIRDFSEELVQQLARRDELEFEKEVKNSFITVLIEVQNKQKEQRELMKKRRKEKGLSLQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 SSRIEKGNQMPLKRFSMEGISNILQSGIRQTFGSSGTDKQYLNTVIPYEKKASPPSVEDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SSRIEKGNQMPLKRFSMEGISNILQSGIRQTFGSSGTDKQYLNTVIPYEKKASPPSVEDL 310 320 330 340 350 360 370 380 390 pF1KB5 QMLTNILFAMKEDNEKVPTLLTDYILKVLCPT :::::::::::::::::::::::::::::::: NP_005 QMLTNILFAMKEDNEKVPTLLTDYILKVLCPT 370 380 390 >>XP_005271792 (OMIM: 604825) PREDICTED: fasciculation a (392 aa) initn: 2551 init1: 2551 opt: 2551 Z-score: 1912.9 bits: 362.8 E(85289): 8.2e-100 Smith-Waterman score: 2551; 100.0% identity (100.0% similar) in 392 aa overlap (1-392:1-392) 10 20 30 40 50 60 pF1KB5 MEAPLVSLDEEFEDLRPSCSEDPEEKPQCFYGSSPHHLEDPSLSELENFSSEIISFKSME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEAPLVSLDEEFEDLRPSCSEDPEEKPQCFYGSSPHHLEDPSLSELENFSSEIISFKSME 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEETLQDEEVWDALTDNYIPSLSED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEETLQDEEVWDALTDNYIPSLSED 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 WRDPNIEALNGNCSDTEIHEKEEEEFNEKSENDSGINEEPLLTADQVIEEIEEMMQNSPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WRDPNIEALNGNCSDTEIHEKEEEEFNEKSENDSGINEEPLLTADQVIEEIEEMMQNSPD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 PEEEEEVLEEEDGGETSSQADSVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDQVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PEEEEEVLEEEDGGETSSQADSVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDQVE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GAIRDFSEELVQQLARRDELEFEKEVKNSFITVLIEVQNKQKEQRELMKKRRKEKGLSLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAIRDFSEELVQQLARRDELEFEKEVKNSFITVLIEVQNKQKEQRELMKKRRKEKGLSLQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 SSRIEKGNQMPLKRFSMEGISNILQSGIRQTFGSSGTDKQYLNTVIPYEKKASPPSVEDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSRIEKGNQMPLKRFSMEGISNILQSGIRQTFGSSGTDKQYLNTVIPYEKKASPPSVEDL 310 320 330 340 350 360 370 380 390 pF1KB5 QMLTNILFAMKEDNEKVPTLLTDYILKVLCPT :::::::::::::::::::::::::::::::: XP_005 QMLTNILFAMKEDNEKVPTLLTDYILKVLCPT 370 380 390 >>XP_005271791 (OMIM: 604825) PREDICTED: fasciculation a (392 aa) initn: 2551 init1: 2551 opt: 2551 Z-score: 1912.9 bits: 362.8 E(85289): 8.2e-100 Smith-Waterman score: 2551; 100.0% identity (100.0% similar) in 392 aa overlap (1-392:1-392) 10 20 30 40 50 60 pF1KB5 MEAPLVSLDEEFEDLRPSCSEDPEEKPQCFYGSSPHHLEDPSLSELENFSSEIISFKSME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEAPLVSLDEEFEDLRPSCSEDPEEKPQCFYGSSPHHLEDPSLSELENFSSEIISFKSME 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEETLQDEEVWDALTDNYIPSLSED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEETLQDEEVWDALTDNYIPSLSED 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 WRDPNIEALNGNCSDTEIHEKEEEEFNEKSENDSGINEEPLLTADQVIEEIEEMMQNSPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WRDPNIEALNGNCSDTEIHEKEEEEFNEKSENDSGINEEPLLTADQVIEEIEEMMQNSPD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 PEEEEEVLEEEDGGETSSQADSVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDQVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PEEEEEVLEEEDGGETSSQADSVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDQVE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GAIRDFSEELVQQLARRDELEFEKEVKNSFITVLIEVQNKQKEQRELMKKRRKEKGLSLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAIRDFSEELVQQLARRDELEFEKEVKNSFITVLIEVQNKQKEQRELMKKRRKEKGLSLQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 SSRIEKGNQMPLKRFSMEGISNILQSGIRQTFGSSGTDKQYLNTVIPYEKKASPPSVEDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSRIEKGNQMPLKRFSMEGISNILQSGIRQTFGSSGTDKQYLNTVIPYEKKASPPSVEDL 310 320 330 340 350 360 370 380 390 pF1KB5 QMLTNILFAMKEDNEKVPTLLTDYILKVLCPT :::::::::::::::::::::::::::::::: XP_005 QMLTNILFAMKEDNEKVPTLLTDYILKVLCPT 370 380 390 >>NP_001036013 (OMIM: 604826) fasciculation and elongati (380 aa) initn: 734 init1: 437 opt: 917 Z-score: 699.7 bits: 138.2 E(85289): 3.1e-32 Smith-Waterman score: 1047; 52.6% identity (77.2% similar) in 342 aa overlap (66-392:54-380) 40 50 60 70 80 90 pF1KB5 HHLEDPSLSELENFSSEIISFKSMEDLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQE ..:::..::: . .: : .. .. NP_001 ENCNASPEPGAEAGAEAGGGADGFPAPACSLEEKLSLCFRPSDPGAE---PPRTAVRPIT 30 40 50 60 70 80 100 110 120 130 140 pF1KB5 EEETLQDEEVWDALTDNYIPSLSEDWRDPNIEALN--------GNCSDTEIHE-KEEEEF :. :: .:.:.:::::: . ::.. . ..:. . ::. . . ...::. NP_001 ERSLLQGDEIWNALTDNYGNVMPVDWKSSHTRTLHLLTLNLSEKGVSDSLLFDTSDDEEL 90 100 110 120 130 140 150 160 170 180 190 200 pF1KB5 NEKSENDSGI----NEEPLLTADQVIEEIEEMMQNSPDPEEEEEVLEEEDGGETSSQAD- :. . : : :.:::.::::::::::::::.:::::..: : .:.: NP_001 REQLDMHSIIVSCVNDEPLFTADQVIEEIEEMMQESPDPEDDE----------TPTQSDR 150 160 170 180 190 210 220 230 240 250 260 pF1KB5 -SVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDQVEGAIRDFSEELVQQLARRDEL :.: ::.:.: .. .... : ....: :::.:.:...: ::...::::::::: :::: NP_001 LSMLSQEIQTLKRSSTGSYE-ERVKRLSVSELNEILEEIETAIKEYSEELVQQLALRDEL 200 210 220 230 240 270 280 290 300 310 320 pF1KB5 EFEKEVKNSFITVLIEVQNKQKEQRELMKKRRKEKGLSLQSSRIEKGNQMPLKRFSMEGI :::::::::::.:::::::::::..: ::..: :. : :... :. ..:: ::::::: NP_001 EFEKEVKNSFISVLIEVQNKQKEHKETAKKKKKLKNGSSQNGKNER-SHMPGTRFSMEGI 250 260 270 280 290 300 330 340 350 360 370 380 pF1KB5 SNILQSGIRQTFGSSGTDKQYLNTVIPYEKKASPPSVEDLQMLTNILFAMKEDNEKVPTL ::..:.:.:.:::.:: .::::.:::::::: .::::::::.::.:: :::::.::::.: NP_001 SNVIQNGLRHTFGNSGGEKQYLTTVIPYEKKNGPPSVEDLQILTKILRAMKEDSEKVPSL 310 320 330 340 350 360 390 pF1KB5 LTDYILKVLCPT :::::::::::: NP_001 LTDYILKVLCPT 370 380 >>XP_006712216 (OMIM: 604826) PREDICTED: fasciculation a (279 aa) initn: 608 init1: 437 opt: 808 Z-score: 620.7 bits: 123.2 E(85289): 7.8e-28 Smith-Waterman score: 942; 60.4% identity (83.5% similar) in 260 aa overlap (135-392:32-279) 110 120 130 140 150 160 pF1KB5 VWDALTDNYIPSLSEDWRDPNIEALNGNCSDTEIHEKEEEEFNEKSENDSGINEEPLLTA :: :. .:... .: : .:.:::.:: XP_006 PVDWKSSHTRTLHLLTLNLSEKGVSDSLLFDTSDDEELREQLDMHSIIVSCVNDEPLFTA 10 20 30 40 50 60 170 180 190 200 210 220 pF1KB5 DQVIEEIEEMMQNSPDPEEEEEVLEEEDGGETSSQAD--SVLLQEMQALTQTFNNNWSYE ::::::::::::.:::::..: : .:.: :.: ::.:.: .. .... : XP_006 DQVIEEIEEMMQESPDPEDDE----------TPTQSDRLSMLSQEIQTLKRSSTGSYE-E 70 80 90 100 110 230 240 250 260 270 280 pF1KB5 GLRHMSGSELTELLDQVEGAIRDFSEELVQQLARRDELEFEKEVKNSFITVLIEVQNKQK ....: :::.:.:...: ::...::::::::: :::::::::::::::.:::::::::: XP_006 RVKRLSVSELNEILEEIETAIKEYSEELVQQLALRDELEFEKEVKNSFISVLIEVQNKQK 120 130 140 150 160 170 290 300 310 320 330 340 pF1KB5 EQRELMKKRRKEKGLSLQSSRIEKGNQMPLKRFSMEGISNILQSGIRQTFGSSGTDKQYL :..: ::..: :. : :... :. ..:: :::::::::..:.:.:.:::.:: .:::: XP_006 EHKETAKKKKKLKNGSSQNGKNER-SHMPGTRFSMEGISNVIQNGLRHTFGNSGGEKQYL 180 190 200 210 220 350 360 370 380 390 pF1KB5 NTVIPYEKKASPPSVEDLQMLTNILFAMKEDNEKVPTLLTDYILKVLCPT .:::::::: .::::::::.::.:: :::::.::::.::::::::::::: XP_006 TTVIPYEKKNGPPSVEDLQILTKILRAMKEDSEKVPSLLTDYILKVLCPT 230 240 250 260 270 >>NP_072043 (OMIM: 604825) fasciculation and elongation (104 aa) initn: 695 init1: 695 opt: 695 Z-score: 543.0 bits: 107.4 E(85289): 1.6e-23 Smith-Waterman score: 695; 100.0% identity (100.0% similar) in 104 aa overlap (1-104:1-104) 10 20 30 40 50 60 pF1KB5 MEAPLVSLDEEFEDLRPSCSEDPEEKPQCFYGSSPHHLEDPSLSELENFSSEIISFKSME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_072 MEAPLVSLDEEFEDLRPSCSEDPEEKPQCFYGSSPHHLEDPSLSELENFSSEIISFKSME 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEETLQDEEVWDALTDNYIPSLSED :::::::::::::::::::::::::::::::::::::::::::: NP_072 DLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEETLQDEE 70 80 90 100 130 140 150 160 170 180 pF1KB5 WRDPNIEALNGNCSDTEIHEKEEEEFNEKSENDSGINEEPLLTADQVIEEIEEMMQNSPD >>NP_005093 (OMIM: 604826) fasciculation and elongation (353 aa) initn: 888 init1: 320 opt: 499 Z-score: 389.8 bits: 80.8 E(85289): 5.7e-15 Smith-Waterman score: 853; 47.7% identity (70.2% similar) in 342 aa overlap (66-392:54-353) 40 50 60 70 80 90 pF1KB5 HHLEDPSLSELENFSSEIISFKSMEDLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQE ..:::..::: . .: : .. .. NP_005 ENCNASPEPGAEAGAEAGGGADGFPAPACSLEEKLSLCFRPSDPGAE---PPRTAVRPIT 30 40 50 60 70 80 100 110 120 130 140 pF1KB5 EEETLQDEEVWDALTDNYIPSLSEDWRDPNIEALN--------GNCSDTEIHE-KEEEEF :. :: .:.:.:::::: . ::.. . ..:. . ::. . . ...::. NP_005 ERSLLQGDEIWNALTDNYGNVMPVDWKSSHTRTLHLLTLNLSEKGVSDSLLFDTSDDEEL 90 100 110 120 130 140 150 160 170 180 190 200 pF1KB5 NEKSENDSGI----NEEPLLTADQVIEEIEEMMQNSPDPEEEEEVLEEEDGGETSSQAD- :. . : : :.:::.::::::::::::::.:::::..: : .:.: NP_005 REQLDMHSIIVSCVNDEPLFTADQVIEEIEEMMQESPDPEDDE----------TPTQSDR 150 160 170 180 190 210 220 230 240 250 260 pF1KB5 -SVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDQVEGAIRDFSEELVQQLARRDEL :.: ::.:.: .. .... : ....: :::.:.:...: ::...::::::::: :::: NP_005 LSMLSQEIQTLKRSSTGSYE-ERVKRLSVSELNEILEEIETAIKEYSEELVQQLALRDEL 200 210 220 230 240 270 280 290 300 310 320 pF1KB5 EFEKEVKNSFITVLIEVQNKQKEQRELMKKRRKEKGLSLQSSRIEKGNQMPLKRFSMEGI :::::::::::.:::::::::::..: ::..: :. : :... :. ..:: NP_005 EFEKEVKNSFISVLIEVQNKQKEHKETAKKKKKLKNGSSQNGKNER-SHMP--------- 250 260 270 280 290 330 340 350 360 370 380 pF1KB5 SNILQSGIRQTFGSSGTDKQYLNTVIPYEKKASPPSVEDLQMLTNILFAMKEDNEKVPTL :: ::.:::::::: .::::::::.::.:: :::::.::::.: NP_005 ---------------GT---YLTTVIPYEKKNGPPSVEDLQILTKILRAMKEDSEKVPSL 300 310 320 330 340 390 pF1KB5 LTDYILKVLCPT :::::::::::: NP_005 LTDYILKVLCPT 350 392 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 21:03:56 2016 done: Sat Nov 5 21:03:57 2016 Total Scan time: 9.820 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]