FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5319, 426 aa 1>>>pF1KB5319 426 - 426 aa - 426 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.8986+/-0.000364; mu= 0.8499+/- 0.023 mean_var=187.1298+/-37.969, 0's: 0 Z-trim(120.1): 45 B-trim: 0 in 0/56 Lambda= 0.093757 statistics sampled from 34787 (34833) to 34787 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.758), E-opt: 0.2 (0.408), width: 16 Scan time: 9.950 The best scores are: opt bits E(85289) NP_005896 (OMIM: 603295,615342) mothers against de ( 430) 2588 362.3 1.4e-99 XP_005266458 (OMIM: 603295,615342) PREDICTED: moth ( 442) 2239 315.1 2.3e-85 NP_005893 (OMIM: 603109,613795) mothers against de ( 425) 1890 267.8 3.6e-71 XP_016881235 (OMIM: 601366) PREDICTED: mothers aga ( 437) 1819 258.2 2.9e-68 NP_001129409 (OMIM: 601366) mothers against decape ( 437) 1819 258.2 2.9e-68 XP_016881237 (OMIM: 601366) PREDICTED: mothers aga ( 414) 1649 235.2 2.3e-61 XP_011524287 (OMIM: 601366) PREDICTED: mothers aga ( 414) 1649 235.2 2.3e-61 XP_016881236 (OMIM: 601366) PREDICTED: mothers aga ( 418) 1649 235.2 2.3e-61 XP_011524286 (OMIM: 601366) PREDICTED: mothers aga ( 425) 1649 235.2 2.4e-61 NP_001138575 (OMIM: 603109,613795) mothers against ( 381) 1648 235.1 2.4e-61 XP_016881234 (OMIM: 601366) PREDICTED: mothers aga ( 467) 1649 235.3 2.6e-61 XP_006722514 (OMIM: 601366) PREDICTED: mothers aga ( 467) 1649 235.3 2.6e-61 NP_001003652 (OMIM: 601366) mothers against decape ( 467) 1649 235.3 2.6e-61 XP_005258316 (OMIM: 601366) PREDICTED: mothers aga ( 467) 1649 235.3 2.6e-61 NP_005892 (OMIM: 601366) mothers against decapenta ( 467) 1649 235.3 2.6e-61 XP_011519862 (OMIM: 603109,613795) PREDICTED: moth ( 376) 1643 234.4 3.8e-61 XP_006714280 (OMIM: 601595) PREDICTED: mothers aga ( 465) 1580 225.9 1.6e-58 XP_011530265 (OMIM: 601595) PREDICTED: mothers aga ( 465) 1580 225.9 1.6e-58 XP_005263049 (OMIM: 601595) PREDICTED: mothers aga ( 465) 1580 225.9 1.6e-58 XP_011530263 (OMIM: 601595) PREDICTED: mothers aga ( 465) 1580 225.9 1.6e-58 XP_011530266 (OMIM: 601595) PREDICTED: mothers aga ( 465) 1580 225.9 1.6e-58 NP_005891 (OMIM: 601595) mothers against decapenta ( 465) 1580 225.9 1.6e-58 NP_001003688 (OMIM: 601595) mothers against decape ( 465) 1580 225.9 1.6e-58 XP_011530264 (OMIM: 601595) PREDICTED: mothers aga ( 465) 1580 225.9 1.6e-58 NP_001001419 (OMIM: 603110) mothers against decape ( 465) 1431 205.8 1.9e-52 XP_016864959 (OMIM: 603110) PREDICTED: mothers aga ( 465) 1431 205.8 1.9e-52 NP_001001420 (OMIM: 603110) mothers against decape ( 465) 1431 205.8 1.9e-52 NP_005894 (OMIM: 603110) mothers against decapenta ( 465) 1431 205.8 1.9e-52 NP_001138574 (OMIM: 603109,613795) mothers against ( 320) 1392 200.4 5.5e-51 NP_001120689 (OMIM: 603295,615342) mothers against ( 467) 1388 200.0 1.1e-50 XP_006719890 (OMIM: 603295,615342) PREDICTED: moth ( 479) 1246 180.8 6.7e-45 XP_011519861 (OMIM: 603109,613795) PREDICTED: moth ( 381) 1153 168.1 3.4e-41 XP_016881239 (OMIM: 601366) PREDICTED: mothers aga ( 227) 1140 166.2 7.5e-41 NP_001138576 (OMIM: 603109,613795) mothers against ( 230) 1139 166.1 8.3e-41 XP_005266460 (OMIM: 603295,615342) PREDICTED: moth ( 393) 1012 149.1 1.9e-35 XP_005266461 (OMIM: 603295,615342) PREDICTED: moth ( 356) 1006 148.2 3.1e-35 XP_016881238 (OMIM: 601366) PREDICTED: mothers aga ( 263) 538 84.8 2.7e-16 NP_005350 (OMIM: 139210,174900,175050,260350,60099 ( 552) 471 76.0 2.7e-13 NP_005576 (OMIM: 602931,614823) mothers against de ( 496) 350 59.6 2.1e-08 XP_011519863 (OMIM: 602931,614823) PREDICTED: moth ( 235) 342 58.3 2.4e-08 NP_001177752 (OMIM: 602932,612229) mothers against ( 238) 312 54.3 4e-07 NP_001177751 (OMIM: 602932,612229) mothers against ( 211) 310 54.0 4.4e-07 >>NP_005896 (OMIM: 603295,615342) mothers against decape (430 aa) initn: 2389 init1: 2389 opt: 2588 Z-score: 1908.8 bits: 362.3 E(85289): 1.4e-99 Smith-Waterman score: 2588; 85.4% identity (94.1% similar) in 426 aa overlap (3-426:7-430) 10 20 30 40 50 pF1KB5 MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALS ..:::::::::::::::::::::::::::::::.::::::::::::.:::.::: NP_005 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 CPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 QKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLG-QNEPHMPLNATFPDS :::::::::::.:::.::::::::::::::::: ::::.::. . ..:: :: :::.::: NP_005 QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 FQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTS-SDPGSPFQMPDVQAVAYEEPKHWCS :::: .: ::. .. .:: ..: ::::: : :.: ::.: : . : ::::.:::: NP_005 FQQPPCSALPPSPSHAFSQSPCTAS--YPHSPGSPSEPESPYQHSDFRPVCYEEPQHWCS 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 IVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKG ..::::::::::.:.::: :::.:::::::::.::::::::::::::::::::::::::: NP_005 VAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKG 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 VHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLA ::::::::::::::.::::::::::::::.:::::.::::::::::::.:::: :::::: NP_005 VHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLA 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 QSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQ :::.::::.::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQ 360 370 380 390 400 410 420 pF1KB5 MGSPHNPISSVS :::::::::::: NP_005 MGSPHNPISSVS 420 430 >>XP_005266458 (OMIM: 603295,615342) PREDICTED: mothers (442 aa) initn: 2040 init1: 2040 opt: 2239 Z-score: 1653.5 bits: 315.1 E(85289): 2.3e-85 Smith-Waterman score: 2239; 83.6% identity (93.4% similar) in 379 aa overlap (3-379:7-383) 10 20 30 40 50 pF1KB5 MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALS ..:::::::::::::::::::::::::::::::.::::::::::::.:::.::: XP_005 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 CPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 QKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLG-QNEPHMPLNATFPDS :::::::::::.:::.::::::::::::::::: ::::.::. . ..:: :: :::.::: XP_005 QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 FQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTS-SDPGSPFQMPDVQAVAYEEPKHWCS :::: .: ::. .. .:: ..: ::::: : :.: ::.: : . : ::::.:::: XP_005 FQQPPCSALPPSPSHAFSQSPCTAS--YPHSPGSPSEPESPYQHSDFRPVCYEEPQHWCS 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 IVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKG ..::::::::::.:.::: :::.:::::::::.::::::::::::::::::::::::::: XP_005 VAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKG 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 VHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLA ::::::::::::::.::::::::::::::.:::::.::::::::::::.:::: :::::: XP_005 VHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLA 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 QSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQ :::.::::.:::::::::::::::: XP_005 QSVHHGFEVVYELTKMCTIRMSFVKVAMKAGEPRKFLSGKERQLGLYMEVKAFSFITCYF 360 370 380 390 400 410 >>NP_005893 (OMIM: 603109,613795) mothers against decape (425 aa) initn: 1042 init1: 913 opt: 1890 Z-score: 1398.6 bits: 267.8 E(85289): 3.6e-71 Smith-Waterman score: 1890; 65.1% identity (82.5% similar) in 435 aa overlap (3-426:1-425) 10 20 30 40 50 pF1KB5 MNVTSLFSFTSPAVKRLLGWKQGDE---EEKWAEKAVDALVKKLKKKKGAMEELEKALSC ..:.. :: : ::::::::.:.. :::: :::: .::::::: : ..:::::.. NP_005 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKT-GQLDELEKAITT 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 PGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQ . ..:.:::::::::::::::::::::::::.::::::.:::::. .: ::: :. :. NP_005 QNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 KEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQ :::.:::::.:::.:::::::::::.: : :.: : . .: :..:: ... NP_005 DEVCVNPYHYQRVETPVLPPVLVPRHTEI-P-----AEFPPLDDYSHSIPENTNFPAGIE 120 130 140 150 160 170 180 190 200 210 220 pF1KB5 QPNSHPFPHSPNSSYPNSPGSSSS-TYPHSPTSSDPG-SPFQM-P-----DVQAVAYEEP :.:. .:..: .: . : .:. . :: ...:. :: : : :.: :.: :: NP_005 -PQSN-IPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEP 180 190 200 210 220 230 240 250 260 270 280 pF1KB5 KHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRR :::: :::::.::::.::::. :. :::::::::.. :::::::::::::...: ::: NP_005 AFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRR 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB5 HIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEF :::.::.:::.::::.:::::::.::::: ::: ..:.::.:::::: ::.::::::::: NP_005 HIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEF 290 300 310 320 330 340 350 360 370 380 390 400 pF1KB5 AQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLD : :::::::.:::.::.::.::::::::::::::::.:: :::::::::.::.::::::: NP_005 AALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLD 350 360 370 380 390 400 410 420 pF1KB5 KVLTQMGSPHNPISSVS ::::::::: :::: NP_005 KVLTQMGSPSIRCSSVS 410 420 >>XP_016881235 (OMIM: 601366) PREDICTED: mothers against (437 aa) initn: 1752 init1: 908 opt: 1819 Z-score: 1346.5 bits: 258.2 E(85289): 2.9e-68 Smith-Waterman score: 1869; 62.7% identity (80.1% similar) in 448 aa overlap (3-426:1-437) 10 20 30 40 pF1KB5 MNVTSLFSFTSPAVKRLLGWK-------------QGDEEEKWAEKAVDALVKKLKKKKGA ..:.. :: :.:::::::: :. .:::: :::: .::::::: : XP_016 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKT-GR 10 20 30 40 50 50 60 70 80 90 100 pF1KB5 MEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLE ..:::::.. . ..:::::::::::::::::::::::::::.::::::.:::::: .: XP_016 LDELEKAITTQNCNTKCVTIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIE 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 CCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMP ::. :. :. :::.:::::.:::.:::::::::::.: .:... : . .: XP_016 NCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTE------ILTELPPLDDYTHSIP 120 130 140 150 160 170 170 180 190 200 210 pF1KB5 LNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQM-P------- :..:: ... :.:. .:..: .: . : .:. .. : : ::: .. : XP_016 ENTNFPAGIE-PQSNYIPETPPPGYISEDGETSDQQLNQ--SMDTGSPAELSPTTLSPVN 180 190 200 210 220 220 230 240 250 260 270 pF1KB5 ---DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLS :.: :.: :: ::::.:::::.::::.::::. :. :::::::::.. :::::::: XP_016 HSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSE-RFCLGLLS 230 240 250 260 270 280 280 290 300 310 320 330 pF1KB5 NVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIP :::::.:.: ::::::.::.:::.::::.:::::::.::::: ::: ..:.::.:::::: XP_016 NVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIP 290 300 310 320 330 340 340 350 360 370 380 390 pF1KB5 SGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCW ::.:::::::::: :::::::.:::.::.::.::::::::::::::::.:: ::::::: XP_016 PGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCW 350 360 370 380 390 400 400 410 420 pF1KB5 IEIHLHGPLQWLDKVLTQMGSPHNPISSVS ::.::.:::::::::::::::: ::.: XP_016 IELHLNGPLQWLDKVLTQMGSPSVRCSSMS 410 420 430 >>NP_001129409 (OMIM: 601366) mothers against decapentap (437 aa) initn: 1752 init1: 908 opt: 1819 Z-score: 1346.5 bits: 258.2 E(85289): 2.9e-68 Smith-Waterman score: 1869; 62.7% identity (80.1% similar) in 448 aa overlap (3-426:1-437) 10 20 30 40 pF1KB5 MNVTSLFSFTSPAVKRLLGWK-------------QGDEEEKWAEKAVDALVKKLKKKKGA ..:.. :: :.:::::::: :. .:::: :::: .::::::: : NP_001 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKT-GR 10 20 30 40 50 50 60 70 80 90 100 pF1KB5 MEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLE ..:::::.. . ..:::::::::::::::::::::::::::.::::::.:::::: .: NP_001 LDELEKAITTQNCNTKCVTIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIE 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 CCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMP ::. :. :. :::.:::::.:::.:::::::::::.: .:... : . .: NP_001 NCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTE------ILTELPPLDDYTHSIP 120 130 140 150 160 170 170 180 190 200 210 pF1KB5 LNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQM-P------- :..:: ... :.:. .:..: .: . : .:. .. : : ::: .. : NP_001 ENTNFPAGIE-PQSNYIPETPPPGYISEDGETSDQQLNQ--SMDTGSPAELSPTTLSPVN 180 190 200 210 220 220 230 240 250 260 270 pF1KB5 ---DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLS :.: :.: :: ::::.:::::.::::.::::. :. :::::::::.. :::::::: NP_001 HSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSE-RFCLGLLS 230 240 250 260 270 280 280 290 300 310 320 330 pF1KB5 NVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIP :::::.:.: ::::::.::.:::.::::.:::::::.::::: ::: ..:.::.:::::: NP_001 NVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIP 290 300 310 320 330 340 340 350 360 370 380 390 pF1KB5 SGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCW ::.:::::::::: :::::::.:::.::.::.::::::::::::::::.:: ::::::: NP_001 PGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCW 350 360 370 380 390 400 400 410 420 pF1KB5 IEIHLHGPLQWLDKVLTQMGSPHNPISSVS ::.::.:::::::::::::::: ::.: NP_001 IELHLNGPLQWLDKVLTQMGSPSVRCSSMS 410 420 430 >>XP_016881237 (OMIM: 601366) PREDICTED: mothers against (414 aa) initn: 1572 init1: 908 opt: 1649 Z-score: 1222.6 bits: 235.2 E(85289): 2.3e-61 Smith-Waterman score: 1652; 65.6% identity (82.7% similar) in 369 aa overlap (69-426:56-414) 40 50 60 70 80 90 pF1KB5 KKLKKKKGAMEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQ ::::::::::::::::::::::.::::::. XP_016 STCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLH 30 40 50 60 70 80 100 110 120 130 140 150 pF1KB5 SHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRN :::::: .: ::. :. :. :::.:::::.:::.:::::::::::.: .:... XP_016 SHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTE------ILTELPP 90 100 110 120 130 160 170 180 190 200 210 pF1KB5 LGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQM : . .: :..:: ... :.:. .:..: .: . : .:. .. : : ::: .. XP_016 LDDYTHSIPENTNFPAGIE-PQSNYIPETPPPGYISEDGETSDQQLNQ--SMDTGSPAEL 140 150 160 170 180 190 220 230 240 250 260 pF1KB5 -P----------DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNK : :.: :.: :: ::::.:::::.::::.::::. :. :::::::::.. XP_016 SPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSE 200 210 220 230 240 250 270 280 290 300 310 320 pF1KB5 NRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGF :::::::::::::.:.: ::::::.::.:::.::::.:::::::.::::: ::: ..:. XP_016 -RFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGW 260 270 280 290 300 310 330 340 350 360 370 380 pF1KB5 HPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHR ::.:::::: ::.:::::::::: :::::::.:::.::.::.::::::::::::::::.: XP_016 HPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRR 320 330 340 350 360 370 390 400 410 420 pF1KB5 QDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS : :::::::::.::.:::::::::::::::: ::.: XP_016 QTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 380 390 400 410 >>XP_011524287 (OMIM: 601366) PREDICTED: mothers against (414 aa) initn: 1572 init1: 908 opt: 1649 Z-score: 1222.6 bits: 235.2 E(85289): 2.3e-61 Smith-Waterman score: 1652; 65.6% identity (82.7% similar) in 369 aa overlap (69-426:56-414) 40 50 60 70 80 90 pF1KB5 KKLKKKKGAMEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQ ::::::::::::::::::::::.::::::. XP_011 STCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLH 30 40 50 60 70 80 100 110 120 130 140 150 pF1KB5 SHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRN :::::: .: ::. :. :. :::.:::::.:::.:::::::::::.: .:... XP_011 SHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTE------ILTELPP 90 100 110 120 130 160 170 180 190 200 210 pF1KB5 LGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQM : . .: :..:: ... :.:. .:..: .: . : .:. .. : : ::: .. XP_011 LDDYTHSIPENTNFPAGIE-PQSNYIPETPPPGYISEDGETSDQQLNQ--SMDTGSPAEL 140 150 160 170 180 190 220 230 240 250 260 pF1KB5 -P----------DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNK : :.: :.: :: ::::.:::::.::::.::::. :. :::::::::.. XP_011 SPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSE 200 210 220 230 240 250 270 280 290 300 310 320 pF1KB5 NRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGF :::::::::::::.:.: ::::::.::.:::.::::.:::::::.::::: ::: ..:. XP_011 -RFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGW 260 270 280 290 300 310 330 340 350 360 370 380 pF1KB5 HPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHR ::.:::::: ::.:::::::::: :::::::.:::.::.::.::::::::::::::::.: XP_011 HPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRR 320 330 340 350 360 370 390 400 410 420 pF1KB5 QDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS : :::::::::.::.:::::::::::::::: ::.: XP_011 QTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 380 390 400 410 >>XP_016881236 (OMIM: 601366) PREDICTED: mothers against (418 aa) initn: 1572 init1: 908 opt: 1649 Z-score: 1222.5 bits: 235.2 E(85289): 2.3e-61 Smith-Waterman score: 1652; 65.6% identity (82.7% similar) in 369 aa overlap (69-426:60-418) 40 50 60 70 80 90 pF1KB5 KKLKKKKGAMEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQ ::::::::::::::::::::::.::::::. XP_016 TTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLH 30 40 50 60 70 80 100 110 120 130 140 150 pF1KB5 SHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRN :::::: .: ::. :. :. :::.:::::.:::.:::::::::::.: .:... XP_016 SHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTE------ILTELPP 90 100 110 120 130 140 160 170 180 190 200 210 pF1KB5 LGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQM : . .: :..:: ... :.:. .:..: .: . : .:. .. : : ::: .. XP_016 LDDYTHSIPENTNFPAGIE-PQSNYIPETPPPGYISEDGETSDQQLNQ--SMDTGSPAEL 150 160 170 180 190 200 220 230 240 250 260 pF1KB5 -P----------DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNK : :.: :.: :: ::::.:::::.::::.::::. :. :::::::::.. XP_016 SPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSE 210 220 230 240 250 260 270 280 290 300 310 320 pF1KB5 NRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGF :::::::::::::.:.: ::::::.::.:::.::::.:::::::.::::: ::: ..:. XP_016 -RFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGW 270 280 290 300 310 330 340 350 360 370 380 pF1KB5 HPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHR ::.:::::: ::.:::::::::: :::::::.:::.::.::.::::::::::::::::.: XP_016 HPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRR 320 330 340 350 360 370 390 400 410 420 pF1KB5 QDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS : :::::::::.::.:::::::::::::::: ::.: XP_016 QTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 380 390 400 410 >>XP_011524286 (OMIM: 601366) PREDICTED: mothers against (425 aa) initn: 1572 init1: 908 opt: 1649 Z-score: 1222.4 bits: 235.2 E(85289): 2.4e-61 Smith-Waterman score: 1652; 65.6% identity (82.7% similar) in 369 aa overlap (69-426:67-425) 40 50 60 70 80 90 pF1KB5 KKLKKKKGAMEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQ ::::::::::::::::::::::.::::::. XP_011 STCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLH 40 50 60 70 80 90 100 110 120 130 140 150 pF1KB5 SHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRN :::::: .: ::. :. :. :::.:::::.:::.:::::::::::.: .:... XP_011 SHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTE------ILTELPP 100 110 120 130 140 150 160 170 180 190 200 210 pF1KB5 LGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQM : . .: :..:: ... :.:. .:..: .: . : .:. .. : : ::: .. XP_011 LDDYTHSIPENTNFPAGIE-PQSNYIPETPPPGYISEDGETSDQQLNQ--SMDTGSPAEL 160 170 180 190 200 220 230 240 250 260 pF1KB5 -P----------DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNK : :.: :.: :: ::::.:::::.::::.::::. :. :::::::::.. XP_011 SPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSE 210 220 230 240 250 260 270 280 290 300 310 320 pF1KB5 NRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGF :::::::::::::.:.: ::::::.::.:::.::::.:::::::.::::: ::: ..:. XP_011 -RFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGW 270 280 290 300 310 320 330 340 350 360 370 380 pF1KB5 HPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHR ::.:::::: ::.:::::::::: :::::::.:::.::.::.::::::::::::::::.: XP_011 HPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRR 330 340 350 360 370 380 390 400 410 420 pF1KB5 QDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS : :::::::::.::.:::::::::::::::: ::.: XP_011 QTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 390 400 410 420 >>NP_001138575 (OMIM: 603109,613795) mothers against dec (381 aa) initn: 942 init1: 913 opt: 1648 Z-score: 1222.4 bits: 235.1 E(85289): 2.4e-61 Smith-Waterman score: 1648; 66.9% identity (83.3% similar) in 366 aa overlap (69-426:25-381) 40 50 60 70 80 90 pF1KB5 KKLKKKKGAMEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQ ::::::::::::::::::::::.::::::. NP_001 MSCLHPRQTWKGAALVHRKAWWMGRSLDGRLQVSHRKGLPHVIYCRLWRWPDLH 10 20 30 40 50 100 110 120 130 140 150 pF1KB5 SHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRN :::::. .: ::: :. :. :::.:::::.:::.:::::::::::.: : :.: NP_001 SHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEI-P-----AEFPP 60 70 80 90 100 160 170 180 190 200 210 pF1KB5 LGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSS-TYPHSPTSSDPG-SPF : . .: :..:: ... :.:. .:..: .: . : .:. . :: ...:. :: NP_001 LDDYSHSIPENTNFPAGIE-PQSN-IPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPN 110 120 130 140 150 160 220 230 240 250 260 270 pF1KB5 QM-P-----DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRF : : :.: :.: :: :::: :::::.::::.::::. :. :::::::::.. :: NP_001 PMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSE-RF 170 180 190 200 210 220 280 290 300 310 320 330 pF1KB5 CLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPT :::::::::::...: ::::::.::.:::.::::.:::::::.::::: ::: ..:.::. NP_001 CLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPA 230 240 250 260 270 280 340 350 360 370 380 390 pF1KB5 TVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDV :::::: ::.:::::::::: :::::::.:::.::.::.::::::::::::::::.:: : NP_001 TVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTV 290 300 310 320 330 340 400 410 420 pF1KB5 TSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS ::::::::.::.:::::::::::::::: :::: NP_001 TSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS 350 360 370 380 426 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 03:36:43 2016 done: Fri Nov 4 03:36:45 2016 Total Scan time: 9.950 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]