FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5326, 450 aa 1>>>pF1KB5326 450 - 450 aa - 450 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2480+/-0.000398; mu= 13.8227+/- 0.025 mean_var=97.8031+/-19.576, 0's: 0 Z-trim(114.9): 52 B-trim: 1014 in 2/54 Lambda= 0.129687 statistics sampled from 24905 (24957) to 24905 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.645), E-opt: 0.2 (0.293), width: 16 Scan time: 9.100 The best scores are: opt bits E(85289) NP_003785 (OMIM: 605931) sorting nexin-4 [Homo sap ( 450) 2981 568.2 1.5e-161 XP_016862903 (OMIM: 605931) PREDICTED: sorting nex ( 482) 1755 338.9 1.8e-92 XP_016856917 (OMIM: 614904) PREDICTED: sorting nex ( 336) 333 72.7 1.6e-12 XP_006710740 (OMIM: 614904) PREDICTED: sorting nex ( 422) 333 72.8 2e-12 XP_006710741 (OMIM: 614904) PREDICTED: sorting nex ( 387) 330 72.2 2.7e-12 XP_016856916 (OMIM: 614904) PREDICTED: sorting nex ( 387) 330 72.2 2.7e-12 XP_016856915 (OMIM: 614904) PREDICTED: sorting nex ( 387) 330 72.2 2.7e-12 XP_011539866 (OMIM: 614904) PREDICTED: sorting nex ( 387) 330 72.2 2.7e-12 XP_016856914 (OMIM: 614904) PREDICTED: sorting nex ( 387) 330 72.2 2.7e-12 NP_057060 (OMIM: 614904) sorting nexin-7 isoform a ( 451) 330 72.2 3.1e-12 NP_001265128 (OMIM: 605929) sorting nexin-2 isofor ( 402) 218 51.3 5.7e-06 NP_003091 (OMIM: 605929) sorting nexin-2 isoform 1 ( 519) 218 51.3 7e-06 NP_001287858 (OMIM: 605930) sorting nexin-3 isofor ( 140) 187 45.2 0.00014 NP_003786 (OMIM: 605930) sorting nexin-3 isoform a ( 162) 187 45.2 0.00015 NP_001243117 (OMIM: 300883) sorting nexin-12 isofo ( 158) 171 42.2 0.0012 NP_037478 (OMIM: 300883) sorting nexin-12 isoform ( 162) 171 42.2 0.0012 NP_001243114 (OMIM: 300883) sorting nexin-12 isofo ( 162) 171 42.2 0.0012 >>NP_003785 (OMIM: 605931) sorting nexin-4 [Homo sapiens (450 aa) initn: 2981 init1: 2981 opt: 2981 Z-score: 3021.3 bits: 568.2 E(85289): 1.5e-161 Smith-Waterman score: 2981; 100.0% identity (100.0% similar) in 450 aa overlap (1-450:1-450) 10 20 30 40 50 60 pF1KB5 MEQAPPDPERQLQPAPLEPLGSPDAGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MEQAPPDPERQLQPAPLEPLGSPDAGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 SVSEAEKRTGRNAMNMQETYTAYLIETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SVSEAEKRTGRNAMNMQETYTAYLIETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 YPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LTQEGNWKETVNETGFQLKADSRLKALNATFRVKNPDKRFTDLKHYSDELQSVISHLLRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LTQEGNWKETVNETGFQLKADSRLKALNATFRVKNPDKRFTDLKHYSDELQSVISHLLRV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 RARVADRLYGVYKVHGNYGRVFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILEDEEHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RARVADRLYGVYKVHGNYGRVFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILEDEEHY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 ADQLKEYLFYAEALRAVCRKHELMQYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ADQLKEYLFYAEALRAVCRKHELMQYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 KLFGQETPEQREARIKVLEEQINEGEQQLKSKNLEGREFVKNAWADIERFKEQKNRDLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KLFGQETPEQREARIKVLEEQINEGEQQLKSKNLEGREFVKNAWADIERFKEQKNRDLKE 370 380 390 400 410 420 430 440 450 pF1KB5 ALISYAVMQISMCKKGIQVWTNAKECFSKM :::::::::::::::::::::::::::::: NP_003 ALISYAVMQISMCKKGIQVWTNAKECFSKM 430 440 450 >>XP_016862903 (OMIM: 605931) PREDICTED: sorting nexin-4 (482 aa) initn: 2967 init1: 1748 opt: 1755 Z-score: 1781.2 bits: 338.9 E(85289): 1.8e-92 Smith-Waterman score: 2907; 93.4% identity (93.4% similar) in 482 aa overlap (1-450:1-482) 10 20 30 40 50 60 pF1KB5 MEQAPPDPERQLQPAPLEPLGSPDAGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEQAPPDPERQLQPAPLEPLGSPDAGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 SVSEAEKRTGRNAMNMQETYTAYLIETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVSEAEKRTGRNAMNMQETYTAYLIETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 YPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LTQEGNWKETVNETGFQLKADSRLKALNATFRVKNPDKRFTDLKHYSDELQSVISHLLRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTQEGNWKETVNETGFQLKADSRLKALNATFRVKNPDKRFTDLKHYSDELQSVISHLLRV 190 200 210 220 230 240 250 260 pF1KB5 RARVADRLYGVYKVHGNYGRVF--------------------------------SEWSAI :::::::::::::::::::::: :::::: XP_016 RARVADRLYGVYKVHGNYGRVFRHSWSLFFFLISWSYKILERPLWFFSSSSRSKSEWSAI 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB5 EKEMGDGLQSAGHHMDVYASSIDDILEDEEHYADQLKEYLFYAEALRAVCRKHELMQYDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKEMGDGLQSAGHHMDVYASSIDDILEDEEHYADQLKEYLFYAEALRAVCRKHELMQYDL 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB5 EMAAQDLASKKQQCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLEEQINEGEQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EMAAQDLASKKQQCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLEEQINEGEQQ 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB5 LKSKNLEGREFVKNAWADIERFKEQKNRDLKEALISYAVMQISMCKKGIQVWTNAKECFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKSKNLEGREFVKNAWADIERFKEQKNRDLKEALISYAVMQISMCKKGIQVWTNAKECFS 430 440 450 460 470 480 450 pF1KB5 KM :: XP_016 KM >>XP_016856917 (OMIM: 614904) PREDICTED: sorting nexin-7 (336 aa) initn: 241 init1: 113 opt: 333 Z-score: 345.6 bits: 72.7 E(85289): 1.6e-12 Smith-Waterman score: 342; 25.5% identity (60.2% similar) in 322 aa overlap (55-371:29-335) 30 40 50 60 70 80 pF1KB5 AGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYL :: . :.:.: :.. .. ::. .: XP_016 MDMNSFSPMMPTSPLSMINQIKFEDEPDLKDLFITVDEPESH-----VTTIETFITYR 10 20 30 40 50 90 100 110 120 130 140 pF1KB5 IETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSAD : :.. . .: . . :::..: :.. : .: ...:::::: :. . . .. XP_016 IITKTSRGEFDSSEFE--VRRRYQDFLWLKGKLEEAHPTLIIPPLPEK---FIVKGM-VE 60 70 80 90 100 150 160 170 180 190 200 pF1KB5 NMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLFLTQEGNWKETVNET---GFQLKAD .. ::.: :: .:..:: :::.:: : .. : .::: .. :. . .. :. . XP_016 RFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQA-WELSSHKKQGPGLLSRMG 110 120 130 140 150 160 210 220 230 240 250 260 pF1KB5 SRLKALNATFR-VKNPDKRFTDLKHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGR . ..:. ...: ::: ..: ..... . ... :. . .. :. . . .:: XP_016 QTVRAVASSMRGVKNRPEEFMEMNNFIELFSQKINLIDKISQRIYKEEREYFDEMKEYGP 170 180 190 200 210 220 270 280 290 300 310 pF1KB5 VFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILED-EEHYADQLKEYLFYAEALRAVCR . ::: :... : :.... .: .. . . : ..::..:.: : .: . XP_016 IHILWSASEEDLVDTLKDVASCIDRCCKATEKRMSGLSEALLPVVHEYVLYSEMLMGVMK 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB5 KHELMQYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLE ... .: .:. .. :. :: . . : .: ..: . :.: .:. :.. XP_016 RRDQIQAELDSKVEVLTYKKADTD-LCLATWESFLTS--QTNLHLEEASEDKP 290 300 310 320 330 380 390 400 410 420 430 pF1KB5 EQINEGEQQLKSKNLEGREFVKNAWADIERFKEQKNRDLKEALISYAVMQISMCKKGIQV >>XP_006710740 (OMIM: 614904) PREDICTED: sorting nexin-7 (422 aa) initn: 241 init1: 113 opt: 333 Z-score: 344.1 bits: 72.8 E(85289): 2e-12 Smith-Waterman score: 342; 25.5% identity (60.2% similar) in 322 aa overlap (55-371:115-421) 30 40 50 60 70 80 pF1KB5 AGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYL :: . :.:.: :.. .. ::. .: XP_006 SLMDMNSFSPMMPTSPLSMINQIKFEDEPDLKDLFITVDEPESH-----VTTIETFITYR 90 100 110 120 130 90 100 110 120 130 140 pF1KB5 IETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSAD : :.. . .: . . :::..: :.. : .: ...:::::: :. . . .. XP_006 IITKTSRGEFDSSEFE--VRRRYQDFLWLKGKLEEAHPTLIIPPLPEK---FIVKGM-VE 140 150 160 170 180 190 150 160 170 180 190 200 pF1KB5 NMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLFLTQEGNWKETVNET---GFQLKAD .. ::.: :: .:..:: :::.:: : .. : .::: .. :. . .. :. . XP_006 RFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQA-WELSSHKKQGPGLLSRMG 200 210 220 230 240 250 210 220 230 240 250 260 pF1KB5 SRLKALNATFR-VKNPDKRFTDLKHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGR . ..:. ...: ::: ..: ..... . ... :. . .. :. . . .:: XP_006 QTVRAVASSMRGVKNRPEEFMEMNNFIELFSQKINLIDKISQRIYKEEREYFDEMKEYGP 260 270 280 290 300 310 270 280 290 300 310 pF1KB5 VFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILED-EEHYADQLKEYLFYAEALRAVCR . ::: :... : :.... .: .. . . : ..::..:.: : .: . XP_006 IHILWSASEEDLVDTLKDVASCIDRCCKATEKRMSGLSEALLPVVHEYVLYSEMLMGVMK 320 330 340 350 360 370 320 330 340 350 360 370 pF1KB5 KHELMQYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLE ... .: .:. .. :. :: . . : .: ..: . :.: .:. :.. XP_006 RRDQIQAELDSKVEVLTYKKADTD-LCLATWESFLTS--QTNLHLEEASEDKP 380 390 400 410 420 380 390 400 410 420 430 pF1KB5 EQINEGEQQLKSKNLEGREFVKNAWADIERFKEQKNRDLKEALISYAVMQISMCKKGIQV >>XP_006710741 (OMIM: 614904) PREDICTED: sorting nexin-7 (387 aa) initn: 279 init1: 113 opt: 330 Z-score: 341.6 bits: 72.2 E(85289): 2.7e-12 Smith-Waterman score: 339; 25.7% identity (60.5% similar) in 296 aa overlap (55-345:29-312) 30 40 50 60 70 80 pF1KB5 AGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYL :: . :.:.: :.. .. ::. .: XP_006 MDMNSFSPMMPTSPLSMINQIKFEDEPDLKDLFITVDEPESH-----VTTIETFITYR 10 20 30 40 50 90 100 110 120 130 140 pF1KB5 IETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSAD : :.. . .: . . :::..: :.. : .: ...:::::: :. . . .. XP_006 IITKTSRGEFDSSEF--EVRRRYQDFLWLKGKLEEAHPTLIIPPLPEK---FIVKGM-VE 60 70 80 90 100 150 160 170 180 190 200 pF1KB5 NMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLFLTQEGNWKETVNET---GFQLKAD .. ::.: :: .:..:: :::.:: : .. : .::: .. :. . .. :. . XP_006 RFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQA-WELSSHKKQGPGLLSRMG 110 120 130 140 150 160 210 220 230 240 250 260 pF1KB5 SRLKALNATFR-VKNPDKRFTDLKHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGR . ..:. ...: ::: ..: ..... . ... :. . .. :. . . .:: XP_006 QTVRAVASSMRGVKNRPEEFMEMNNFIELFSQKINLIDKISQRIYKEEREYFDEMKEYGP 170 180 190 200 210 220 270 280 290 300 310 pF1KB5 VFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILED-EEHYADQLKEYLFYAEALRAVCR . ::: :... : :.... .: .. . . : ..::..:.: : .: . XP_006 IHILWSASEEDLVDTLKDVASCIDRCCKATEKRMSGLSEALLPVVHEYVLYSEMLMGVMK 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB5 KHELMQYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLE ... .: .:. .. :. :: . . : XP_006 RRDQIQAELDSKVEVLTYKKADTDLLPEEIGKLEDKVECANNALKADWERWKQNMQNDIK 290 300 310 320 330 340 >>XP_016856916 (OMIM: 614904) PREDICTED: sorting nexin-7 (387 aa) initn: 279 init1: 113 opt: 330 Z-score: 341.6 bits: 72.2 E(85289): 2.7e-12 Smith-Waterman score: 339; 25.7% identity (60.5% similar) in 296 aa overlap (55-345:29-312) 30 40 50 60 70 80 pF1KB5 AGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYL :: . :.:.: :.. .. ::. .: XP_016 MDMNSFSPMMPTSPLSMINQIKFEDEPDLKDLFITVDEPESH-----VTTIETFITYR 10 20 30 40 50 90 100 110 120 130 140 pF1KB5 IETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSAD : :.. . .: . . :::..: :.. : .: ...:::::: :. . . .. XP_016 IITKTSRGEFDSSEF--EVRRRYQDFLWLKGKLEEAHPTLIIPPLPEK---FIVKGM-VE 60 70 80 90 100 150 160 170 180 190 200 pF1KB5 NMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLFLTQEGNWKETVNET---GFQLKAD .. ::.: :: .:..:: :::.:: : .. : .::: .. :. . .. :. . XP_016 RFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQA-WELSSHKKQGPGLLSRMG 110 120 130 140 150 160 210 220 230 240 250 260 pF1KB5 SRLKALNATFR-VKNPDKRFTDLKHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGR . ..:. ...: ::: ..: ..... . ... :. . .. :. . . .:: XP_016 QTVRAVASSMRGVKNRPEEFMEMNNFIELFSQKINLIDKISQRIYKEEREYFDEMKEYGP 170 180 190 200 210 220 270 280 290 300 310 pF1KB5 VFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILED-EEHYADQLKEYLFYAEALRAVCR . ::: :... : :.... .: .. . . : ..::..:.: : .: . XP_016 IHILWSASEEDLVDTLKDVASCIDRCCKATEKRMSGLSEALLPVVHEYVLYSEMLMGVMK 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB5 KHELMQYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLE ... .: .:. .. :. :: . . : XP_016 RRDQIQAELDSKVEVLTYKKADTDLLPEEIGKLEDKVECANNALKADWERWKQNMQNDIK 290 300 310 320 330 340 >>XP_016856915 (OMIM: 614904) PREDICTED: sorting nexin-7 (387 aa) initn: 279 init1: 113 opt: 330 Z-score: 341.6 bits: 72.2 E(85289): 2.7e-12 Smith-Waterman score: 339; 25.7% identity (60.5% similar) in 296 aa overlap (55-345:29-312) 30 40 50 60 70 80 pF1KB5 AGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYL :: . :.:.: :.. .. ::. .: XP_016 MDMNSFSPMMPTSPLSMINQIKFEDEPDLKDLFITVDEPESH-----VTTIETFITYR 10 20 30 40 50 90 100 110 120 130 140 pF1KB5 IETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSAD : :.. . .: . . :::..: :.. : .: ...:::::: :. . . .. XP_016 IITKTSRGEFDSSEF--EVRRRYQDFLWLKGKLEEAHPTLIIPPLPEK---FIVKGM-VE 60 70 80 90 100 150 160 170 180 190 200 pF1KB5 NMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLFLTQEGNWKETVNET---GFQLKAD .. ::.: :: .:..:: :::.:: : .. : .::: .. :. . .. :. . XP_016 RFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQA-WELSSHKKQGPGLLSRMG 110 120 130 140 150 160 210 220 230 240 250 260 pF1KB5 SRLKALNATFR-VKNPDKRFTDLKHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGR . ..:. ...: ::: ..: ..... . ... :. . .. :. . . .:: XP_016 QTVRAVASSMRGVKNRPEEFMEMNNFIELFSQKINLIDKISQRIYKEEREYFDEMKEYGP 170 180 190 200 210 220 270 280 290 300 310 pF1KB5 VFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILED-EEHYADQLKEYLFYAEALRAVCR . ::: :... : :.... .: .. . . : ..::..:.: : .: . XP_016 IHILWSASEEDLVDTLKDVASCIDRCCKATEKRMSGLSEALLPVVHEYVLYSEMLMGVMK 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB5 KHELMQYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLE ... .: .:. .. :. :: . . : XP_016 RRDQIQAELDSKVEVLTYKKADTDLLPEEIGKLEDKVECANNALKADWERWKQNMQNDIK 290 300 310 320 330 340 >>XP_011539866 (OMIM: 614904) PREDICTED: sorting nexin-7 (387 aa) initn: 279 init1: 113 opt: 330 Z-score: 341.6 bits: 72.2 E(85289): 2.7e-12 Smith-Waterman score: 339; 25.7% identity (60.5% similar) in 296 aa overlap (55-345:29-312) 30 40 50 60 70 80 pF1KB5 AGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYL :: . :.:.: :.. .. ::. .: XP_011 MDMNSFSPMMPTSPLSMINQIKFEDEPDLKDLFITVDEPESH-----VTTIETFITYR 10 20 30 40 50 90 100 110 120 130 140 pF1KB5 IETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSAD : :.. . .: . . :::..: :.. : .: ...:::::: :. . . .. XP_011 IITKTSRGEFDSSEF--EVRRRYQDFLWLKGKLEEAHPTLIIPPLPEK---FIVKGM-VE 60 70 80 90 100 150 160 170 180 190 200 pF1KB5 NMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLFLTQEGNWKETVNET---GFQLKAD .. ::.: :: .:..:: :::.:: : .. : .::: .. :. . .. :. . XP_011 RFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQA-WELSSHKKQGPGLLSRMG 110 120 130 140 150 160 210 220 230 240 250 260 pF1KB5 SRLKALNATFR-VKNPDKRFTDLKHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGR . ..:. ...: ::: ..: ..... . ... :. . .. :. . . .:: XP_011 QTVRAVASSMRGVKNRPEEFMEMNNFIELFSQKINLIDKISQRIYKEEREYFDEMKEYGP 170 180 190 200 210 220 270 280 290 300 310 pF1KB5 VFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILED-EEHYADQLKEYLFYAEALRAVCR . ::: :... : :.... .: .. . . : ..::..:.: : .: . XP_011 IHILWSASEEDLVDTLKDVASCIDRCCKATEKRMSGLSEALLPVVHEYVLYSEMLMGVMK 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB5 KHELMQYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLE ... .: .:. .. :. :: . . : XP_011 RRDQIQAELDSKVEVLTYKKADTDLLPEEIGKLEDKVECANNALKADWERWKQNMQNDIK 290 300 310 320 330 340 >>XP_016856914 (OMIM: 614904) PREDICTED: sorting nexin-7 (387 aa) initn: 279 init1: 113 opt: 330 Z-score: 341.6 bits: 72.2 E(85289): 2.7e-12 Smith-Waterman score: 339; 25.7% identity (60.5% similar) in 296 aa overlap (55-345:29-312) 30 40 50 60 70 80 pF1KB5 AGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYL :: . :.:.: :.. .. ::. .: XP_016 MDMNSFSPMMPTSPLSMINQIKFEDEPDLKDLFITVDEPESH-----VTTIETFITYR 10 20 30 40 50 90 100 110 120 130 140 pF1KB5 IETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSAD : :.. . .: . . :::..: :.. : .: ...:::::: :. . . .. XP_016 IITKTSRGEFDSSEF--EVRRRYQDFLWLKGKLEEAHPTLIIPPLPEK---FIVKGM-VE 60 70 80 90 100 150 160 170 180 190 200 pF1KB5 NMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLFLTQEGNWKETVNET---GFQLKAD .. ::.: :: .:..:: :::.:: : .. : .::: .. :. . .. :. . XP_016 RFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQA-WELSSHKKQGPGLLSRMG 110 120 130 140 150 160 210 220 230 240 250 260 pF1KB5 SRLKALNATFR-VKNPDKRFTDLKHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGR . ..:. ...: ::: ..: ..... . ... :. . .. :. . . .:: XP_016 QTVRAVASSMRGVKNRPEEFMEMNNFIELFSQKINLIDKISQRIYKEEREYFDEMKEYGP 170 180 190 200 210 220 270 280 290 300 310 pF1KB5 VFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILED-EEHYADQLKEYLFYAEALRAVCR . ::: :... : :.... .: .. . . : ..::..:.: : .: . XP_016 IHILWSASEEDLVDTLKDVASCIDRCCKATEKRMSGLSEALLPVVHEYVLYSEMLMGVMK 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB5 KHELMQYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLE ... .: .:. .. :. :: . . : XP_016 RRDQIQAELDSKVEVLTYKKADTDLLPEEIGKLEDKVECANNALKADWERWKQNMQNDIK 290 300 310 320 330 340 >>NP_057060 (OMIM: 614904) sorting nexin-7 isoform a [Ho (451 aa) initn: 241 init1: 113 opt: 330 Z-score: 340.7 bits: 72.2 E(85289): 3.1e-12 Smith-Waterman score: 339; 25.7% identity (60.5% similar) in 296 aa overlap (55-345:93-376) 30 40 50 60 70 80 pF1KB5 AGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYL :: . :.:.: :.. .. ::. .: NP_057 SLMDMNSFSPMMPTSPLSMINQIKFEDEPDLKDLFITVDEPESH-----VTTIETFITYR 70 80 90 100 110 90 100 110 120 130 140 pF1KB5 IETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSAD : :.. . .: . . :::..: :.. : .: ...:::::: :. . . .. NP_057 IITKTSRGEFDSSEF--EVRRRYQDFLWLKGKLEEAHPTLIIPPLPEK---FIVKGM-VE 120 130 140 150 160 170 150 160 170 180 190 200 pF1KB5 NMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLFLTQEGNWKETVNET---GFQLKAD .. ::.: :: .:..:: :::.:: : .. : .::: .. :. . .. :. . NP_057 RFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQA-WELSSHKKQGPGLLSRMG 180 190 200 210 220 230 210 220 230 240 250 260 pF1KB5 SRLKALNATFR-VKNPDKRFTDLKHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGR . ..:. ...: ::: ..: ..... . ... :. . .. :. . . .:: NP_057 QTVRAVASSMRGVKNRPEEFMEMNNFIELFSQKINLIDKISQRIYKEEREYFDEMKEYGP 240 250 260 270 280 290 270 280 290 300 310 pF1KB5 VFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILED-EEHYADQLKEYLFYAEALRAVCR . ::: :... : :.... .: .. . . : ..::..:.: : .: . NP_057 IHILWSASEEDLVDTLKDVASCIDRCCKATEKRMSGLSEALLPVVHEYVLYSEMLMGVMK 300 310 320 330 340 350 320 330 340 350 360 370 pF1KB5 KHELMQYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLE ... .: .:. .. :. :: . . : NP_057 RRDQIQAELDSKVEVLTYKKADTDLLPEEIGKLEDKVECANNALKADWERWKQNMQNDIK 360 370 380 390 400 410 450 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 12:28:23 2016 done: Sat Nov 5 12:28:24 2016 Total Scan time: 9.100 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]