FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5335, 653 aa 1>>>pF1KB5335 653 - 653 aa - 653 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3606+/-0.00127; mu= 17.7660+/- 0.077 mean_var=263.5856+/-49.926, 0's: 0 Z-trim(110.8): 956 B-trim: 53 in 1/51 Lambda= 0.078998 statistics sampled from 10810 (11885) to 10810 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.688), E-opt: 0.2 (0.365), width: 16 Scan time: 3.720 The best scores are: opt bits E(32554) CCDS13134.1 ZNF133 gene_id:7692|Hs108|chr20 ( 653) 4678 547.4 2.3e-155 CCDS63234.1 ZNF133 gene_id:7692|Hs108|chr20 ( 654) 4666 546.0 5.8e-155 CCDS63233.1 ZNF133 gene_id:7692|Hs108|chr20 ( 657) 4666 546.1 5.9e-155 CCDS74703.1 ZNF133 gene_id:7692|Hs108|chr20 ( 667) 4419 517.9 1.8e-146 CCDS63235.1 ZNF133 gene_id:7692|Hs108|chr20 ( 591) 4194 492.2 8.7e-139 CCDS74704.1 ZNF133 gene_id:7692|Hs108|chr20 ( 635) 4194 492.2 9e-139 CCDS82338.1 HKR1 gene_id:284459|Hs108|chr19 ( 640) 2455 294.0 4.1e-79 CCDS12502.1 HKR1 gene_id:284459|Hs108|chr19 ( 659) 2455 294.1 4.2e-79 CCDS82337.1 HKR1 gene_id:284459|Hs108|chr19 ( 641) 2443 292.7 1.1e-78 CCDS82339.1 HKR1 gene_id:284459|Hs108|chr19 ( 598) 2290 275.2 1.8e-73 CCDS74693.1 ZNF343 gene_id:79175|Hs108|chr20 ( 640) 2108 254.5 3.3e-67 CCDS43307.1 PRDM9 gene_id:56979|Hs108|chr5 ( 894) 2077 251.2 4.6e-66 CCDS59418.1 ZNF615 gene_id:284370|Hs108|chr19 ( 742) 1970 238.9 1.9e-62 CCDS74692.1 ZNF343 gene_id:79175|Hs108|chr20 ( 509) 1951 236.4 7.2e-62 CCDS13028.1 ZNF343 gene_id:79175|Hs108|chr20 ( 599) 1951 236.6 7.8e-62 CCDS12970.2 ZNF135 gene_id:7694|Hs108|chr19 ( 670) 1882 228.8 1.9e-59 CCDS54329.1 ZNF135 gene_id:7694|Hs108|chr19 ( 682) 1882 228.8 1.9e-59 CCDS12848.1 ZNF432 gene_id:9668|Hs108|chr19 ( 652) 1829 222.7 1.3e-57 CCDS13174.1 ZNF337 gene_id:26152|Hs108|chr20 ( 751) 1827 222.6 1.6e-57 CCDS31940.1 ZNF84 gene_id:7637|Hs108|chr12 ( 738) 1783 217.6 5.1e-56 CCDS12846.1 ZNF615 gene_id:284370|Hs108|chr19 ( 731) 1765 215.5 2.1e-55 CCDS82387.1 ZNF615 gene_id:284370|Hs108|chr19 ( 736) 1765 215.5 2.1e-55 CCDS33091.1 ZNF528 gene_id:84436|Hs108|chr19 ( 628) 1736 212.1 1.9e-54 CCDS74472.1 ZNF135 gene_id:7694|Hs108|chr19 ( 616) 1735 212.0 2e-54 CCDS74471.1 ZNF135 gene_id:7694|Hs108|chr19 ( 658) 1735 212.0 2.1e-54 CCDS82341.1 ZNF569 gene_id:148266|Hs108|chr19 ( 527) 1728 211.1 3.3e-54 CCDS12503.1 ZNF569 gene_id:148266|Hs108|chr19 ( 686) 1728 211.2 3.8e-54 CCDS4311.2 ZNF300 gene_id:91975|Hs108|chr5 ( 604) 1720 210.2 6.6e-54 CCDS54940.1 ZNF300 gene_id:91975|Hs108|chr5 ( 620) 1720 210.3 6.7e-54 CCDS12500.1 ZNF585B gene_id:92285|Hs108|chr19 ( 769) 1714 209.7 1.2e-53 CCDS35067.1 ZNF484 gene_id:83744|Hs108|chr9 ( 816) 1712 209.5 1.4e-53 CCDS35066.1 ZNF484 gene_id:83744|Hs108|chr9 ( 852) 1712 209.6 1.5e-53 CCDS59136.1 ZNF484 gene_id:83744|Hs108|chr9 ( 854) 1712 209.6 1.5e-53 CCDS12499.1 ZNF585A gene_id:199704|Hs108|chr19 ( 714) 1701 208.2 3.2e-53 CCDS74353.1 ZNF585A gene_id:199704|Hs108|chr19 ( 769) 1701 208.2 3.4e-53 CCDS56092.1 ZNF568 gene_id:374900|Hs108|chr19 ( 580) 1696 207.5 4.3e-53 CCDS42558.1 ZNF568 gene_id:374900|Hs108|chr19 ( 644) 1696 207.5 4.6e-53 CCDS35235.1 ZNF182 gene_id:7569|Hs108|chrX ( 620) 1695 207.4 4.8e-53 CCDS35236.1 ZNF182 gene_id:7569|Hs108|chrX ( 639) 1695 207.4 4.9e-53 CCDS6437.1 ZNF16 gene_id:7564|Hs108|chr8 ( 682) 1694 207.4 5.5e-53 CCDS6709.2 ZNF169 gene_id:169841|Hs108|chr9 ( 603) 1691 206.9 6.5e-53 CCDS45012.1 ZNF268 gene_id:10795|Hs108|chr12 ( 947) 1692 207.4 7.6e-53 CCDS7198.1 ZNF33B gene_id:7582|Hs108|chr10 ( 778) 1687 206.7 1e-52 CCDS33048.1 ZNF235 gene_id:9310|Hs108|chr19 ( 738) 1683 206.2 1.4e-52 CCDS14279.1 ZNF41 gene_id:7592|Hs108|chrX ( 779) 1681 206.0 1.6e-52 CCDS46212.1 ZNF814 gene_id:730051|Hs108|chr19 ( 855) 1665 204.2 6.1e-52 CCDS12497.1 ZNF345 gene_id:25850|Hs108|chr19 ( 488) 1661 203.4 6.3e-52 CCDS76895.1 ZNF23 gene_id:7571|Hs108|chr16 ( 585) 1654 202.7 1.2e-51 CCDS10900.1 ZNF23 gene_id:7571|Hs108|chr16 ( 643) 1654 202.8 1.3e-51 CCDS73089.1 ZNF33A gene_id:7581|Hs108|chr10 ( 699) 1651 202.5 1.7e-51 >>CCDS13134.1 ZNF133 gene_id:7692|Hs108|chr20 (653 aa) initn: 4678 init1: 4678 opt: 4678 Z-score: 2902.9 bits: 547.4 E(32554): 2.3e-155 Smith-Waterman score: 4678; 99.8% identity (100.0% similar) in 653 aa overlap (1-653:1-653) 10 20 30 40 50 60 pF1KB5 MAFRDVAVDFTQDEWRLLSPAQRTLYREVMLENYSNLVSLGISFSKPELITQLEQGKETW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MAFRDVAVDFTQDEWRLLSPAQRTLYREVMLENYSNLVSLGISFSKPELITQLEQGKETW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 REEKKCSPATCPDPEPELYLDPFCPPGFSSQKFPMQHVLCNHPPWIFTCLCAEGNIQPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 REEKKCSPATCPDPEPELYLDPFCPPGFSSQKFPMQHVLCNHPPWIFTCLCAEGNIQPGD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 PGPGDQEKQQQASEGRPWSDQAEGPEGEGAMPLFGRTKKRTLGAFSRPPQRQPVSSRNGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 PGPGDQEKQQQASEGRPWSDQAEGPEGEGAMPLFGRTKKRTLGAFSRPPQRQPVSSRNGL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RGVELEASPAQTGNPEETDKLLKRIEVLGFGTVNCGECGLSFSKMTNLLSHQRIHSGEKP :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 RGVELEASPAQSGNPEETDKLLKRIEVLGFGTVNCGECGLSFSKMTNLLSHQRIHSGEKP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 YVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTHSGEKPYMCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 YVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTHSGEKPYMCS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 ECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVRHQRTHLEEKTIVCSDCGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 ECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVRHQRTHLEEKTIVCSDCGL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 GFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRTHSKEKPYVCGVCGHSFSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 GFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRTHSKEKPYVCGVCGHSFSQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 NSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKPIVCKDCGRGFSQQSNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 NSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKPIVCKDCGRGFSQQSNL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 IRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYVCRECGRGFSHQAGLIRHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 IRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYVCRECGRGFSHQAGLIRHK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 RKHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQKSHLTLHQMTHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 RKHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQKSHLTLHQMTHT 550 560 570 580 590 600 610 620 630 640 650 pF1KB5 GEKPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPCAGQPSDSLYSL ::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 GEKPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPCAGQPSDSLYSL 610 620 630 640 650 >>CCDS63234.1 ZNF133 gene_id:7692|Hs108|chr20 (654 aa) initn: 4194 init1: 4194 opt: 4666 Z-score: 2895.5 bits: 546.0 E(32554): 5.8e-155 Smith-Waterman score: 4666; 99.7% identity (99.8% similar) in 654 aa overlap (1-653:1-654) 10 20 30 40 50 60 pF1KB5 MAFRDVAVDFTQDEWRLLSPAQRTLYREVMLENYSNLVSLGISFSKPELITQLEQGKETW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 MAFRDVAVDFTQDEWRLLSPAQRTLYREVMLENYSNLVSLGISFSKPELITQLEQGKETW 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 REEKKCSPATCP-DPEPELYLDPFCPPGFSSQKFPMQHVLCNHPPWIFTCLCAEGNIQPG :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 REEKKCSPATCPADPEPELYLDPFCPPGFSSQKFPMQHVLCNHPPWIFTCLCAEGNIQPG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 DPGPGDQEKQQQASEGRPWSDQAEGPEGEGAMPLFGRTKKRTLGAFSRPPQRQPVSSRNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 DPGPGDQEKQQQASEGRPWSDQAEGPEGEGAMPLFGRTKKRTLGAFSRPPQRQPVSSRNG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 LRGVELEASPAQTGNPEETDKLLKRIEVLGFGTVNCGECGLSFSKMTNLLSHQRIHSGEK ::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 LRGVELEASPAQSGNPEETDKLLKRIEVLGFGTVNCGECGLSFSKMTNLLSHQRIHSGEK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 PYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTHSGEKPYMC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 PYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTHSGEKPYMC 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 SECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVRHQRTHLEEKTIVCSDCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 SECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVRHQRTHLEEKTIVCSDCG 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 LGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRTHSKEKPYVCGVCGHSFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 LGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRTHSKEKPYVCGVCGHSFS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 QNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKPIVCKDCGRGFSQQSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 QNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKPIVCKDCGRGFSQQSN 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 LIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYVCRECGRGFSHQAGLIRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 LIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYVCRECGRGFSHQAGLIRH 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB5 KRKHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQKSHLTLHQMTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 KRKHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQKSHLTLHQMTH 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB5 TGEKPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPCAGQPSDSLYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 TGEKPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPCAGQPSDSLYSL 610 620 630 640 650 >>CCDS63233.1 ZNF133 gene_id:7692|Hs108|chr20 (657 aa) initn: 4194 init1: 4194 opt: 4666 Z-score: 2895.5 bits: 546.1 E(32554): 5.9e-155 Smith-Waterman score: 4666; 99.7% identity (99.8% similar) in 654 aa overlap (1-653:4-657) 10 20 30 40 50 pF1KB5 MAFRDVAVDFTQDEWRLLSPAQRTLYREVMLENYSNLVSLGISFSKPELITQLEQGK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 MAHMAFRDVAVDFTQDEWRLLSPAQRTLYREVMLENYSNLVSLGISFSKPELITQLEQGK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 ETWREEKKCSPATCP-DPEPELYLDPFCPPGFSSQKFPMQHVLCNHPPWIFTCLCAEGNI ::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::: CCDS63 ETWREEKKCSPATCPADPEPELYLDPFCPPGFSSQKFPMQHVLCNHPPWIFTCLCAEGNI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 QPGDPGPGDQEKQQQASEGRPWSDQAEGPEGEGAMPLFGRTKKRTLGAFSRPPQRQPVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 QPGDPGPGDQEKQQQASEGRPWSDQAEGPEGEGAMPLFGRTKKRTLGAFSRPPQRQPVSS 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 RNGLRGVELEASPAQTGNPEETDKLLKRIEVLGFGTVNCGECGLSFSKMTNLLSHQRIHS :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: CCDS63 RNGLRGVELEASPAQSGNPEETDKLLKRIEVLGFGTVNCGECGLSFSKMTNLLSHQRIHS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 GEKPYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTHSGEKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 GEKPYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTHSGEKP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 YMCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVRHQRTHLEEKTIVCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 YMCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVRHQRTHLEEKTIVCS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 DCGLGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRTHSKEKPYVCGVCGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 DCGLGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRTHSKEKPYVCGVCGH 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 SFSQNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKPIVCKDCGRGFSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 SFSQNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKPIVCKDCGRGFSQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 QSNLIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYVCRECGRGFSHQAGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 QSNLIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYVCRECGRGFSHQAGL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB5 IRHKRKHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQKSHLTLHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 IRHKRKHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQKSHLTLHQ 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB5 MTHTGEKPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPCAGQPSDSLYSL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 MTHTGEKPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPCAGQPSDSLYSL 610 620 630 640 650 >>CCDS74703.1 ZNF133 gene_id:7692|Hs108|chr20 (667 aa) initn: 4419 init1: 4419 opt: 4419 Z-score: 2743.3 bits: 517.9 E(32554): 1.8e-146 Smith-Waterman score: 4419; 99.8% identity (100.0% similar) in 613 aa overlap (41-653:55-667) 20 30 40 50 60 70 pF1KB5 TQDEWRLLSPAQRTLYREVMLENYSNLVSLGISFSKPELITQLEQGKETWREEKKCSPAT :::::::::::::::::::::::::::::: CCDS74 PRIRGSVVLAPRWRSSPAGGWSDPLFFGGAGISFSKPELITQLEQGKETWREEKKCSPAT 30 40 50 60 70 80 80 90 100 110 120 130 pF1KB5 CPDPEPELYLDPFCPPGFSSQKFPMQHVLCNHPPWIFTCLCAEGNIQPGDPGPGDQEKQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 CPDPEPELYLDPFCPPGFSSQKFPMQHVLCNHPPWIFTCLCAEGNIQPGDPGPGDQEKQQ 90 100 110 120 130 140 140 150 160 170 180 190 pF1KB5 QASEGRPWSDQAEGPEGEGAMPLFGRTKKRTLGAFSRPPQRQPVSSRNGLRGVELEASPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 QASEGRPWSDQAEGPEGEGAMPLFGRTKKRTLGAFSRPPQRQPVSSRNGLRGVELEASPA 150 160 170 180 190 200 200 210 220 230 240 250 pF1KB5 QTGNPEETDKLLKRIEVLGFGTVNCGECGLSFSKMTNLLSHQRIHSGEKPYVCGVCEKGF :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 QSGNPEETDKLLKRIEVLGFGTVNCGECGLSFSKMTNLLSHQRIHSGEKPYVCGVCEKGF 210 220 230 240 250 260 260 270 280 290 300 310 pF1KB5 SLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTHSGEKPYMCSECGRGFSQKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 SLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTHSGEKPYMCSECGRGFSQKS 270 280 290 300 310 320 320 330 340 350 360 370 pF1KB5 NLIIHQRTHSGEKPYVCRECGKGFSQKSAVVRHQRTHLEEKTIVCSDCGLGFSDRSNLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 NLIIHQRTHSGEKPYVCRECGKGFSQKSAVVRHQRTHLEEKTIVCSDCGLGFSDRSNLIS 330 340 350 360 370 380 380 390 400 410 420 430 pF1KB5 HQRTHSGEKPYACKECGRCFRQRTTLVNHQRTHSKEKPYVCGVCGHSFSQNSTLISHRRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 HQRTHSGEKPYACKECGRCFRQRTTLVNHQRTHSKEKPYVCGVCGHSFSQNSTLISHRRT 390 400 410 420 430 440 440 450 460 470 480 490 pF1KB5 HTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKPIVCKDCGRGFSQQSNLIRHQRTHSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 HTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKPIVCKDCGRGFSQQSNLIRHQRTHSGE 450 460 470 480 490 500 500 510 520 530 540 550 pF1KB5 KPMVCGECGRGFSQKSNLVAHQRTHSGERPYVCRECGRGFSHQAGLIRHKRKHSREKPYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 KPMVCGECGRGFSQKSNLVAHQRTHSGERPYVCRECGRGFSHQAGLIRHKRKHSREKPYM 510 520 530 540 550 560 560 570 580 590 600 610 pF1KB5 CRQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQKSHLTLHQMTHTGEKPYVCKTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 CRQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQKSHLTLHQMTHTGEKPYVCKTC 570 580 590 600 610 620 620 630 640 650 pF1KB5 GRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPCAGQPSDSLYSL ::::::::::::::::::::::::::::::::::::::::::: CCDS74 GRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPCAGQPSDSLYSL 630 640 650 660 >>CCDS63235.1 ZNF133 gene_id:7692|Hs108|chr20 (591 aa) initn: 4194 init1: 4194 opt: 4194 Z-score: 2605.2 bits: 492.2 E(32554): 8.7e-139 Smith-Waterman score: 4194; 99.8% identity (100.0% similar) in 581 aa overlap (73-653:11-591) 50 60 70 80 90 100 pF1KB5 SFSKPELITQLEQGKETWREEKKCSPATCPDPEPELYLDPFCPPGFSSQKFPMQHVLCNH :::::::::::::::::::::::::::::: CCDS63 MCNGRKTVLADPEPELYLDPFCPPGFSSQKFPMQHVLCNH 10 20 30 40 110 120 130 140 150 160 pF1KB5 PPWIFTCLCAEGNIQPGDPGPGDQEKQQQASEGRPWSDQAEGPEGEGAMPLFGRTKKRTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 PPWIFTCLCAEGNIQPGDPGPGDQEKQQQASEGRPWSDQAEGPEGEGAMPLFGRTKKRTL 50 60 70 80 90 100 170 180 190 200 210 220 pF1KB5 GAFSRPPQRQPVSSRNGLRGVELEASPAQTGNPEETDKLLKRIEVLGFGTVNCGECGLSF :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: CCDS63 GAFSRPPQRQPVSSRNGLRGVELEASPAQSGNPEETDKLLKRIEVLGFGTVNCGECGLSF 110 120 130 140 150 160 230 240 250 260 270 280 pF1KB5 SKMTNLLSHQRIHSGEKPYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 SKMTNLLSHQRIHSGEKPYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKS 170 180 190 200 210 220 290 300 310 320 330 340 pF1KB5 TLIIHERTHSGEKPYMCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 TLIIHERTHSGEKPYMCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVR 230 240 250 260 270 280 350 360 370 380 390 400 pF1KB5 HQRTHLEEKTIVCSDCGLGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 HQRTHLEEKTIVCSDCGLGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRT 290 300 310 320 330 340 410 420 430 440 450 460 pF1KB5 HSKEKPYVCGVCGHSFSQNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 HSKEKPYVCGVCGHSFSQNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGE 350 360 370 380 390 400 470 480 490 500 510 520 pF1KB5 KPIVCKDCGRGFSQQSNLIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 KPIVCKDCGRGFSQQSNLIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYV 410 420 430 440 450 460 530 540 550 560 570 580 pF1KB5 CRECGRGFSHQAGLIRHKRKHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCREC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 CRECGRGFSHQAGLIRHKRKHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCREC 470 480 490 500 510 520 590 600 610 620 630 640 pF1KB5 GQGFLQKSHLTLHQMTHTGEKPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 GQGFLQKSHLTLHQMTHTGEKPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPC 530 540 550 560 570 580 650 pF1KB5 AGQPSDSLYSL ::::::::::: CCDS63 AGQPSDSLYSL 590 >>CCDS74704.1 ZNF133 gene_id:7692|Hs108|chr20 (635 aa) initn: 4194 init1: 4194 opt: 4194 Z-score: 2604.9 bits: 492.2 E(32554): 9e-139 Smith-Waterman score: 4194; 99.8% identity (100.0% similar) in 581 aa overlap (73-653:55-635) 50 60 70 80 90 100 pF1KB5 SFSKPELITQLEQGKETWREEKKCSPATCPDPEPELYLDPFCPPGFSSQKFPMQHVLCNH :::::::::::::::::::::::::::::: CCDS74 PRIRGSVVLAPRWRSSPAGGWSDPLFFGGADPEPELYLDPFCPPGFSSQKFPMQHVLCNH 30 40 50 60 70 80 110 120 130 140 150 160 pF1KB5 PPWIFTCLCAEGNIQPGDPGPGDQEKQQQASEGRPWSDQAEGPEGEGAMPLFGRTKKRTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 PPWIFTCLCAEGNIQPGDPGPGDQEKQQQASEGRPWSDQAEGPEGEGAMPLFGRTKKRTL 90 100 110 120 130 140 170 180 190 200 210 220 pF1KB5 GAFSRPPQRQPVSSRNGLRGVELEASPAQTGNPEETDKLLKRIEVLGFGTVNCGECGLSF :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: CCDS74 GAFSRPPQRQPVSSRNGLRGVELEASPAQSGNPEETDKLLKRIEVLGFGTVNCGECGLSF 150 160 170 180 190 200 230 240 250 260 270 280 pF1KB5 SKMTNLLSHQRIHSGEKPYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 SKMTNLLSHQRIHSGEKPYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKS 210 220 230 240 250 260 290 300 310 320 330 340 pF1KB5 TLIIHERTHSGEKPYMCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 TLIIHERTHSGEKPYMCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVR 270 280 290 300 310 320 350 360 370 380 390 400 pF1KB5 HQRTHLEEKTIVCSDCGLGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 HQRTHLEEKTIVCSDCGLGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRT 330 340 350 360 370 380 410 420 430 440 450 460 pF1KB5 HSKEKPYVCGVCGHSFSQNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 HSKEKPYVCGVCGHSFSQNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGE 390 400 410 420 430 440 470 480 490 500 510 520 pF1KB5 KPIVCKDCGRGFSQQSNLIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 KPIVCKDCGRGFSQQSNLIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYV 450 460 470 480 490 500 530 540 550 560 570 580 pF1KB5 CRECGRGFSHQAGLIRHKRKHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCREC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 CRECGRGFSHQAGLIRHKRKHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCREC 510 520 530 540 550 560 590 600 610 620 630 640 pF1KB5 GQGFLQKSHLTLHQMTHTGEKPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 GQGFLQKSHLTLHQMTHTGEKPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPC 570 580 590 600 610 620 650 pF1KB5 AGQPSDSLYSL ::::::::::: CCDS74 AGQPSDSLYSL 630 >>CCDS82338.1 HKR1 gene_id:284459|Hs108|chr19 (640 aa) initn: 2027 init1: 2027 opt: 2455 Z-score: 1533.7 bits: 294.0 E(32554): 4.1e-79 Smith-Waterman score: 2455; 56.4% identity (76.9% similar) in 631 aa overlap (1-628:14-639) 10 20 30 40 pF1KB5 MAFRDVAVDFTQDEWRLLSPAQRTLYREVMLENYSNLVSLGISFSKP .::::::: :::.::::::::::::.::::::.:..:::: : ::: CCDS82 MATGLLRAKKEAFVAFRDVAVYFTQEEWRLLSPAQRTLHREVMLETYNHLVSLEIPSSKP 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 ELITQLEQGKETWREEKKCSPATCPDPEPELYLDPFCPPGFSSQKFPMQHVLCNHPPWIF .::.:::.:. ::::.:: ::. .::. :.: :: ::::. ::: .: .: CCDS82 KLIAQLERGEAPWREERKCPLDLCPESKPEIQLSPSCPLIFSSQQALSQHVWLSHLSQLF 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB5 TCLCAEGNIQPGDPGPGDQEKQQQASEGRPWSDQAEG-PEGEGAMPLFGRTKKR-TLGAF . : : . .. : : :: :::: . .: .:: ::: . ::::..: : :. CCDS82 SSLWAGNPLHLGKHYPEDQ-KQQQ--DPFCFSGKAEWIQEGEDSRLLFGRVSKNGTSKAL 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 SRPPQ-RQPVSSRNGLRGVELEASPAQTGNPEETDKLLKRIEVLGFGTVNCGECGLSFSK : ::. .::..:.. :.. .:: . .. :::::.:. .:: ::: .. : : .: : CCDS82 SSPPEEQQPAQSKEDNTVVDIGSSPERRADLEETDKVLHGLEVSGFGEIKYEEFGPGFIK 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB5 MTNLLSHQRIHSGEKPYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTL .:::: :. ..:: ::. .:. . : .. ..::: :: :::::::::. ::.: CCDS82 ESNLLSLQKTQTGETPYMYTEWGDSFGSMSVLIKNPRTHSGGKPYVCRECGRGFTWKSNL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB5 IIHERTHSGEKPYMCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVRHQ : :.:::::::::.:..:::::. ::::. ::::::: :::::.:::..:: :: .. :: CCDS82 ITHQRTHSGEKPYVCKDCGRGFTWKSNLFTHQRTHSGLKPYVCKECGQSFSLKSNLITHQ 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB5 RTHLEEKTIVCSDCGLGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRTHS :.: :: :: .:: :: ..:.:. :.::::::::: :.:: . : :.. :. : :::. CCDS82 RAHTGEKPYVCRECGRGFRQHSHLVRHKRTHSGEKPYICRECEQGFSQKSHLIRHLRTHT 360 370 380 390 400 410 410 420 430 440 450 460 pF1KB5 KEKPYVCGVCGHSFSQNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKP :::::: ::. :: .:.: .:.:::.: ::::: ::. :::::.::.:: :.:::: CCDS82 GEKPYVCTECGRHFSWKSNLKTHQRTHSGVKPYVCLECGQCFSLKSNLNKHQRSHTGEKP 420 430 440 450 460 470 470 480 490 500 510 520 pF1KB5 IVCKDCGRGFSQQSNLIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYVCR .:: .:::::...:.: ::::::::::.::.::::::..::.:..::::::::.:..:: CCDS82 FVCTECGRGFTRKSTLSTHQRTHSGEKPFVCAECGRGFNDKSTLISHQRTHSGEKPFMCR 480 490 500 510 520 530 530 540 550 560 570 580 pF1KB5 ECGRGFSHQAGLIRHKRKHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCRECGQ :::: : .. .:.:::: :: ..::.:: :: : .:: :.:::. :: ::::::: CCDS82 ECGRRFRQKPNLFRHKRAHS--GAFVCRECGQGFCAKLTLIKHQRAHAGGKPHVCRECGQ 540 550 560 570 580 590 590 600 610 620 630 640 pF1KB5 GFLQKSHLTLHQMTHTGEKPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPCAG :: ..::: :: ::.:::::.:. :::::: ::.: ::..: : CCDS82 GFSRQSHLIRHQRTHSGEKPYICRKCGRGFSRKSNLIRHQRTHSG 600 610 620 630 640 650 pF1KB5 QPSDSLYSL >>CCDS12502.1 HKR1 gene_id:284459|Hs108|chr19 (659 aa) initn: 2027 init1: 2027 opt: 2455 Z-score: 1533.6 bits: 294.1 E(32554): 4.2e-79 Smith-Waterman score: 2455; 56.4% identity (76.9% similar) in 631 aa overlap (1-628:33-658) 10 20 30 pF1KB5 MAFRDVAVDFTQDEWRLLSPAQRTLYREVM .::::::: :::.::::::::::::.:::: CCDS12 VNHTVSTMLPTCMVHRQTMSCSGAGGITAFVAFRDVAVYFTQEEWRLLSPAQRTLHREVM 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 LENYSNLVSLGISFSKPELITQLEQGKETWREEKKCSPATCPDPEPELYLDPFCPPGFSS ::.:..:::: : :::.::.:::.:. ::::.:: ::. .::. :.: :: ::: CCDS12 LETYNHLVSLEIPSSKPKLIAQLERGEAPWREERKCPLDLCPESKPEIQLSPSCPLIFSS 70 80 90 100 110 120 100 110 120 130 140 pF1KB5 QKFPMQHVLCNHPPWIFTCLCAEGNIQPGDPGPGDQEKQQQASEGRPWSDQAEG-PEGEG :. ::: .: .:. : : . .. : : :: :::: . .: .:: ::: CCDS12 QQALSQHVWLSHLSQLFSSLWAGNPLHLGKHYPEDQ-KQQQ--DPFCFSGKAEWIQEGED 130 140 150 160 170 150 160 170 180 190 200 pF1KB5 AMPLFGRTKKR-TLGAFSRPPQ-RQPVSSRNGLRGVELEASPAQTGNPEETDKLLKRIEV . ::::..: : :.: ::. .::..:.. :.. .:: . .. :::::.:. .:: CCDS12 SRLLFGRVSKNGTSKALSSPPEEQQPAQSKEDNTVVDIGSSPERRADLEETDKVLHGLEV 180 190 200 210 220 230 210 220 230 240 250 260 pF1KB5 LGFGTVNCGECGLSFSKMTNLLSHQRIHSGEKPYVCGVCEKGFSLKKSLARHQKAHSGEK ::: .. : : .: : .:::: :. ..:: ::. .:. . : .. ..::: : CCDS12 SGFGEIKYEEFGPGFIKESNLLSLQKTQTGETPYMYTEWGDSFGSMSVLIKNPRTHSGGK 240 250 260 270 280 290 270 280 290 300 310 320 pF1KB5 PIVCRECGRGFNRKSTLIIHERTHSGEKPYMCSECGRGFSQKSNLIIHQRTHSGEKPYVC : :::::::::. ::.:: :.:::::::::.:..:::::. ::::. ::::::: ::::: CCDS12 PYVCRECGRGFTWKSNLITHQRTHSGEKPYVCKDCGRGFTWKSNLFTHQRTHSGLKPYVC 300 310 320 330 340 350 330 340 350 360 370 380 pF1KB5 RECGKGFSQKSAVVRHQRTHLEEKTIVCSDCGLGFSDRSNLISHQRTHSGEKPYACKECG .:::..:: :: .. :::.: :: :: .:: :: ..:.:. :.::::::::: :.:: CCDS12 KECGQSFSLKSNLITHQRAHTGEKPYVCRECGRGFRQHSHLVRHKRTHSGEKPYICRECE 360 370 380 390 400 410 390 400 410 420 430 440 pF1KB5 RCFRQRTTLVNHQRTHSKEKPYVCGVCGHSFSQNSTLISHRRTHTGEKPYVCGVCGRGFS . : :.. :. : :::. :::::: ::. :: .:.: .:.:::.: ::::: ::. :: CCDS12 QGFSQKSHLIRHLRTHTGEKPYVCTECGRHFSWKSNLKTHQRTHSGVKPYVCLECGQCFS 420 430 440 450 460 470 450 460 470 480 490 500 pF1KB5 LKSHLNRHQNIHSGEKPIVCKDCGRGFSQQSNLIRHQRTHSGEKPMVCGECGRGFSQKSN :::.::.:: :.::::.:: .:::::...:.: ::::::::::.::.::::::..::. CCDS12 LKSNLNKHQRSHTGEKPFVCTECGRGFTRKSTLSTHQRTHSGEKPFVCAECGRGFNDKST 480 490 500 510 520 530 510 520 530 540 550 560 pF1KB5 LVAHQRTHSGERPYVCRECGRGFSHQAGLIRHKRKHSREKPYMCRQCGLGFGNKSALITH :..::::::::.:..:::::: : .. .:.:::: :: ..::.:: :: : .:: : CCDS12 LISHQRTHSGEKPFMCRECGRRFRQKPNLFRHKRAHS--GAFVCRECGQGFCAKLTLIKH 540 550 560 570 580 590 570 580 590 600 610 620 pF1KB5 KRAHSEEKPCVCRECGQGFLQKSHLTLHQMTHTGEKPYVCKTCGRGFSLKSHLSRHRKTT .:::. :: ::::::::: ..::: :: ::.:::::.:. :::::: ::.: ::..: CCDS12 QRAHAGGKPHVCRECGQGFSRQSHLIRHQRTHSGEKPYICRKCGRGFSRKSNLIRHQRTH 600 610 620 630 640 650 630 640 650 pF1KB5 SVHHRLPVQPDPEPCAGQPSDSLYSL : CCDS12 SG >>CCDS82337.1 HKR1 gene_id:284459|Hs108|chr19 (641 aa) initn: 1687 init1: 1687 opt: 2443 Z-score: 1526.3 bits: 292.7 E(32554): 1.1e-78 Smith-Waterman score: 2443; 56.3% identity (76.7% similar) in 632 aa overlap (1-628:14-640) 10 20 30 40 pF1KB5 MAFRDVAVDFTQDEWRLLSPAQRTLYREVMLENYSNLVSLGISFSKP .::::::: :::.::::::::::::.::::::.:..:::: : ::: CCDS82 MATGLLRAKKEAFVAFRDVAVYFTQEEWRLLSPAQRTLHREVMLETYNHLVSLEIPSSKP 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 ELITQLEQGKETWREEKKCSPATCP-DPEPELYLDPFCPPGFSSQKFPMQHVLCNHPPWI .::.:::.:. ::::.:: :: . .::. :.: :: ::::. ::: .: . CCDS82 KLIAQLERGEAPWREERKCPLDLCPAESKPEIQLSPSCPLIFSSQQALSQHVWLSHLSQL 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB5 FTCLCAEGNIQPGDPGPGDQEKQQQASEGRPWSDQAEG-PEGEGAMPLFGRTKKR-TLGA :. : : . .. : : :: :::: . .: .:: ::: . ::::..: : : CCDS82 FSSLWAGNPLHLGKHYPEDQ-KQQQ--DPFCFSGKAEWIQEGEDSRLLFGRVSKNGTSKA 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 FSRPPQ-RQPVSSRNGLRGVELEASPAQTGNPEETDKLLKRIEVLGFGTVNCGECGLSFS .: ::. .::..:.. :.. .:: . .. :::::.:. .:: ::: .. : : .: CCDS82 LSSPPEEQQPAQSKEDNTVVDIGSSPERRADLEETDKVLHGLEVSGFGEIKYEEFGPGFI 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB5 KMTNLLSHQRIHSGEKPYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKST : .:::: :. ..:: ::. .:. . : .. ..::: :: :::::::::. ::. CCDS82 KESNLLSLQKTQTGETPYMYTEWGDSFGSMSVLIKNPRTHSGGKPYVCRECGRGFTWKSN 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB5 LIIHERTHSGEKPYMCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVRH :: :.:::::::::.:..:::::. ::::. ::::::: :::::.:::..:: :: .. : CCDS82 LITHQRTHSGEKPYVCKDCGRGFTWKSNLFTHQRTHSGLKPYVCKECGQSFSLKSNLITH 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB5 QRTHLEEKTIVCSDCGLGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRTH ::.: :: :: .:: :: ..:.:. :.::::::::: :.:: . : :.. :. : ::: CCDS82 QRAHTGEKPYVCRECGRGFRQHSHLVRHKRTHSGEKPYICRECEQGFSQKSHLIRHLRTH 360 370 380 390 400 410 410 420 430 440 450 460 pF1KB5 SKEKPYVCGVCGHSFSQNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEK . :::::: ::. :: .:.: .:.:::.: ::::: ::. :::::.::.:: :.::: CCDS82 TGEKPYVCTECGRHFSWKSNLKTHQRTHSGVKPYVCLECGQCFSLKSNLNKHQRSHTGEK 420 430 440 450 460 470 470 480 490 500 510 520 pF1KB5 PIVCKDCGRGFSQQSNLIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYVC :.:: .:::::...:.: ::::::::::.::.::::::..::.:..::::::::.:..: CCDS82 PFVCTECGRGFTRKSTLSTHQRTHSGEKPFVCAECGRGFNDKSTLISHQRTHSGEKPFMC 480 490 500 510 520 530 530 540 550 560 570 580 pF1KB5 RECGRGFSHQAGLIRHKRKHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCRECG ::::: : .. .:.:::: :: ..::.:: :: : .:: :.:::. :: :::::: CCDS82 RECGRRFRQKPNLFRHKRAHS--GAFVCRECGQGFCAKLTLIKHQRAHAGGKPHVCRECG 540 550 560 570 580 590 590 600 610 620 630 640 pF1KB5 QGFLQKSHLTLHQMTHTGEKPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPCA ::: ..::: :: ::.:::::.:. :::::: ::.: ::..: : CCDS82 QGFSRQSHLIRHQRTHSGEKPYICRKCGRGFSRKSNLIRHQRTHSG 600 610 620 630 640 650 pF1KB5 GQPSDSLYSL >>CCDS82339.1 HKR1 gene_id:284459|Hs108|chr19 (598 aa) initn: 1862 init1: 1862 opt: 2290 Z-score: 1432.4 bits: 275.2 E(32554): 1.8e-73 Smith-Waterman score: 2290; 54.7% identity (75.9% similar) in 602 aa overlap (30-628:1-597) 10 20 30 40 50 60 pF1KB5 MAFRDVAVDFTQDEWRLLSPAQRTLYREVMLENYSNLVSLGISFSKPELITQLEQGKETW :::.:..:::: : :::.::.:::.:. : CCDS82 MLETYNHLVSLEIPSSKPKLIAQLERGEAPW 10 20 30 70 80 90 100 110 120 pF1KB5 REEKKCSPATCPDPEPELYLDPFCPPGFSSQKFPMQHVLCNHPPWIFTCLCAEGNIQPGD :::.:: ::. .::. :.: :: ::::. ::: .: .:. : : . .. : CCDS82 REERKCPLDLCPESKPEIQLSPSCPLIFSSQQALSQHVWLSHLSQLFSSLWAGNPLHLGK 40 50 60 70 80 90 130 140 150 160 170 pF1KB5 PGPGDQEKQQQASEGRPWSDQAEG-PEGEGAMPLFGRTKKR-TLGAFSRPPQ-RQPVSSR : ::..:: . .: .:: ::: . ::::..: : :.: ::. .::..:. CCDS82 HYPEDQKQQQ---DPFCFSGKAEWIQEGEDSRLLFGRVSKNGTSKALSSPPEEQQPAQSK 100 110 120 130 140 180 190 200 210 220 230 pF1KB5 NGLRGVELEASPAQTGNPEETDKLLKRIEVLGFGTVNCGECGLSFSKMTNLLSHQRIHSG . :.. .:: . .. :::::.:. .:: ::: .. : : .: : .:::: :. ..: CCDS82 EDNTVVDIGSSPERRADLEETDKVLHGLEVSGFGEIKYEEFGPGFIKESNLLSLQKTQTG 150 160 170 180 190 200 240 250 260 270 280 290 pF1KB5 EKPYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTHSGEKPY : ::. .:. . : .. ..::: :: :::::::::. ::.:: :.::::::::: CCDS82 ETPYMYTEWGDSFGSMSVLIKNPRTHSGGKPYVCRECGRGFTWKSNLITHQRTHSGEKPY 210 220 230 240 250 260 300 310 320 330 340 350 pF1KB5 MCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVRHQRTHLEEKTIVCSD .:..:::::. ::::. ::::::: :::::.:::..:: :: .. :::.: :: :: . CCDS82 VCKDCGRGFTWKSNLFTHQRTHSGLKPYVCKECGQSFSLKSNLITHQRAHTGEKPYVCRE 270 280 290 300 310 320 360 370 380 390 400 410 pF1KB5 CGLGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRTHSKEKPYVCGVCGHS :: :: ..:.:. :.::::::::: :.:: . : :.. :. : :::. :::::: ::. CCDS82 CGRGFRQHSHLVRHKRTHSGEKPYICRECEQGFSQKSHLIRHLRTHTGEKPYVCTECGRH 330 340 350 360 370 380 420 430 440 450 460 470 pF1KB5 FSQNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKPIVCKDCGRGFSQQ :: .:.: .:.:::.: ::::: ::. :::::.::.:: :.::::.:: .:::::... CCDS82 FSWKSNLKTHQRTHSGVKPYVCLECGQCFSLKSNLNKHQRSHTGEKPFVCTECGRGFTRK 390 400 410 420 430 440 480 490 500 510 520 530 pF1KB5 SNLIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYVCRECGRGFSHQAGLI :.: ::::::::::.::.::::::..::.:..::::::::.:..:::::: : .. .:. CCDS82 STLSTHQRTHSGEKPFVCAECGRGFNDKSTLISHQRTHSGEKPFMCRECGRRFRQKPNLF 450 460 470 480 490 500 540 550 560 570 580 590 pF1KB5 RHKRKHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQKSHLTLHQM :::: :: ..::.:: :: : .:: :.:::. :: ::::::::: ..::: :: CCDS82 RHKRAHS--GAFVCRECGQGFCAKLTLIKHQRAHAGGKPHVCRECGQGFSRQSHLIRHQR 510 520 530 540 550 560 600 610 620 630 640 650 pF1KB5 THTGEKPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPCAGQPSDSLYSL ::.:::::.:. :::::: ::.: ::..: : CCDS82 THSGEKPYICRKCGRGFSRKSNLIRHQRTHSG 570 580 590 653 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 17:12:20 2016 done: Thu Nov 3 17:12:21 2016 Total Scan time: 3.720 Total Display time: 0.170 Function used was FASTA [36.3.4 Apr, 2011]